text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
bay k 8644 ( methyl-1,4-dihydro-2,6-dimethyl-3-nitro-4- ( 2-trifluoromethylphenyl ) pyridine-5-carboxylate ) and cgp 28 392 ( ethyl-4 ( 2-difluoromethoxyphenyl ) -1,4,5,7-tetrahydro-2-methyl-5-++ +oxofuro- [ 3,4-b ] pyridine-3-carboxylate ) are closely related in structure to nifedipine and other 1,4-dihydropyridine ca... | NA | {
"id": "C0028066",
"name": "nifedipine",
"pos": [
277,
287
]
} | {
"id": "C0012315",
"name": "dihydropyridine",
"pos": [
302,
317
]
} |
the present studies , therefore , provide an important link between recent information regarding the mechanism of nacl transport in the thick ascending limb and older whole animal studies suggesting an important role for distal chloride delivery in urine concentration . | NA | {
"id": "C0037494",
"name": "nacl",
"pos": [
114,
118
]
} | {
"id": "C0008203",
"name": "chloride",
"pos": [
228,
236
]
} |
a recombinant dna library has been constructed using flow sorted chromosome # 13 dna and the phage vector , charon 21a . | NA | {
"id": "C0012931",
"name": "recombinant dna",
"pos": [
2,
17
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
81,
84
]
} |
vitamin e , both in the form of dl-alpha-tocopherol and dl-alpha-tocopheryl acetate , was capable of inducing an increased alkaline elution rate of liver dna from rats treated i.p . with the vitamin . | NA | {
"id": "C0042874",
"name": "vitamin e",
"pos": [
0,
9
]
} | {
"id": "C0994472",
"name": "dl-alpha-tocopheryl",
"pos": [
56,
75
]
} |
igm monoclonal antibodies directed against tumor cells which do not mediate antibody-dependent macrophage cytotoxicity ( admc ) even when they are cytotoxic in the presence of complement , have been shown to render macrophages tumoricidal when they carry an immunomodulating agent , i.e. , muramyldipeptide ( mdp ) . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
4,
25
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
76,
84
]
} |
it was found that in normal syngeneic spleen cells this fraction induced effector cells that efficiently killed ( at various e : t ratios ) the relevant b16 target cells and rbl5 syngeneic tumor cells , but not the yac allogeneic tumor cells or c57bl/6 lymphoblasts . | NA | {
"id": "C0007634",
"name": "normal",
"pos": [
21,
27
]
} | {
"id": "C3485979",
"name": "allogeneic",
"pos": [
219,
229
]
} |
cytosolic estrogen ( er ) , progesterone ( pr ) , androgen ( ar ) , and glucocorticoid ( gr ) receptors were evaluated in 6 meningiomas and 12 gliomas ( 6 astrocytomas and 6 glioblastomas ) using a dextran-coated charcoal method . | NA | {
"id": "C0004114",
"name": "astrocytomas",
"pos": [
155,
167
]
} | {
"id": "C0017636",
"name": "glioblastomas",
"pos": [
174,
187
]
} |
we examined the cytosolic estrogen receptor ( er ) level in tumor tissue from 77 patients : 36 meningiomas , 20 gliomas ( 12 glioblastomas , 2 cerebellar astrocytomas , 2 ependymomas , and 4 medulloblastomas ) , 8 neurinomas , 7 pituitary adenomas ( 2 prolactin-producing adenomas , 1 growth hormone-producing adenoma , ... | NA | {
"id": "C0017638",
"name": "gliomas",
"pos": [
112,
119
]
} | {
"id": "C0014474",
"name": "ependymomas",
"pos": [
171,
182
]
} |
we examined the cytosolic estrogen receptor ( er ) level in tumor tissue from 77 patients : 36 meningiomas , 20 gliomas ( 12 glioblastomas , 2 cerebellar astrocytomas , 2 ependymomas , and 4 medulloblastomas ) , 8 neurinomas , 7 pituitary adenomas ( 2 prolactin-producing adenomas , 1 growth hormone-producing adenoma , ... | NA | {
"id": "C0017638",
"name": "gliomas",
"pos": [
112,
119
]
} | {
"id": "C0025149",
"name": "medulloblastomas",
"pos": [
191,
207
]
} |
an abrupt reduction of nuclear volume occurred with increasing ion concentration , this contraction being more pronounced with bivalent ( either ca2+ or mg2+ ) than with monovalent ( either na+ or k+ ) cations . | NA | {
"id": "C0022023",
"name": "ion",
"pos": [
16,
19
]
} | {
"id": "C0007447",
"name": "cations",
"pos": [
202,
209
]
} |
to avoid intracellular freezing and its usually lethal consequences , cells must lose their freezable water before reaching their ice-nucleation temperature . | NA | {
"id": "C0043047",
"name": "water",
"pos": [
102,
107
]
} | {
"id": "C0020746",
"name": "ice",
"pos": [
130,
133
]
} |
since the ice-nucleation temperature of mouse ova in the cryoprotectants dmso and glycerol is usually below -30 degrees c , the arrhenius form of the water-loss equation was used to compute the extent of supercooling in ova cooled at rates between 1 and 8 degrees c/min and the consequent likelihood of intracellular fre... | NA | {
"id": "C0020746",
"name": "ice",
"pos": [
10,
13
]
} | {
"id": "C0043047",
"name": "water",
"pos": [
150,
155
]
} |
all the cells bind the con a specifically , but a different pattern of agglutination is present in fibroblasts of the two embryonic ages . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
8,
13
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
99,
110
]
} |
since con a is well known to bind carbohydrate-containing surface proteins , the result suggests that the release of gag by chick embryonic fibroblasts can be modulated by cell surface receptors . | NA | {
"id": "C0025252",
"name": "surface proteins",
"pos": [
58,
74
]
} | {
"id": "C0034800",
"name": "cell surface receptors",
"pos": [
172,
194
]
} |
previous evidence has established the similarity between ( na+ + k+ ) -atpase ( atp phosphohydrolase , ec.3.6.1.3 ) and the antigen recognized by the rat antimouse monoclonal antibody anti-bsp-3 . | NA | {
"id": "C0001479",
"name": "na",
"pos": [
59,
61
]
} | {
"id": "C0001473",
"name": "atp",
"pos": [
80,
83
]
} |
the orderly arrangement of fibroblasts and collagen in tendons and ligaments suggests that these cells may have precise relationships with one another and with the collagen fibrils . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
27,
38
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
97,
102
]
} |
the genital haemal sinus , and sometimes portions of the surrounding genital coelomic sinus , contain a fine granular ground substance and amoeboid cells . | NA | {
"id": "C0080304",
"name": "haemal sinus",
"pos": [
12,
24
]
} | {
"id": "C0016169",
"name": "sinus",
"pos": [
86,
91
]
} |
controls carried out on adjacent sections with absorbed antiserum or different antibodies raised against several biologically active peptides of vertebrates ( acth-17-39 , alpha- and beta endorphin , alpha- and beta msh , methionin-enkephalin , trh ) demonstrate the specificity of the `` '' staining '' '' . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
56,
65
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
79,
89
]
} |
human lung fibroblast mrc-5 cells treated with triton x-100 ( mrc-5 cell models ) were able to contract in the presence of mgatp and ca2+ of more than 1 microm . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
11,
21
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
68,
72
]
} |
non-hydrolyzable analogues , including beta , gamma-imidoadenosine-5'-triphosphate ( amppnp ) , beta , gamma-methylene adenosine-5'-triphosphate ( amppcp ) , and atp gamma s , will not substitute for atp in reactivation of movement . | NA | {
"id": "C0001506",
"name": "amppnp",
"pos": [
85,
91
]
} | {
"id": "C0001480",
"name": "adenosine-5",
"pos": [
119,
130
]
} |
microinjection of simian adenovirus sa7 ( c-8 ) dna into the mouse zygotes : differential distribution of viral dna in organs . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
48,
51
]
} | {
"id": "C0012939",
"name": "viral dna",
"pos": [
106,
115
]
} |
to study the effect of zinc on the proliferative response to polyclonal t cell mitogens , spleen cells from c57bl/6 mice were cultured with or without zncl2 and stimulated with graded doses of concanavalin a or phytohemagglutinin . | NA | {
"id": "C0043481",
"name": "zinc",
"pos": [
23,
27
]
} | {
"id": "C0078774",
"name": "zncl2",
"pos": [
151,
156
]
} |
amyloid protein aa is believed to be synthesized in the liver in a form of its precursor , the acute phase reactant , saa . | NA | {
"id": "C0001347",
"name": "acute phase reactant",
"pos": [
95,
115
]
} | {
"id": "C0002723",
"name": "saa",
"pos": [
118,
121
]
} |
yonge ( 1924 ) and van weel ( 1955 ) attempted to obtain evidence for the absorptive function of hepatopancreas cells of nephrops norvegicus and atya spinides using iron lactate and iron saccharate , and obtained some positive results . | NA | {
"id": "C0302583",
"name": "iron",
"pos": [
165,
169
]
} | {
"id": "C0060241",
"name": "iron saccharate",
"pos": [
182,
197
]
} |
the expression of src gene in dense cultures of chick embryo fibroblasts ( cef ) infected by a thermosensitive mutant ( ny68 ) of rsv released density-dependent inhibition of growth and induced in these cells a large increase in dna , rna and protein synthesis . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
61,
72
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
203,
208
]
} |
the induction by phenobarbital ( pb ) of aldrin epoxidase ( ae ) and aryl hydrocarbon hydroxylase ( ahh ) , markers of cytochrome p-450- and cytochrome p-448-dependent monooxygenases , was studied in cell lines derived from reuber h35 rat hepatoma which differ widely in their degree of differentiation . | NA | {
"id": "C0003927",
"name": "aryl",
"pos": [
69,
73
]
} | {
"id": "C0010762",
"name": "cytochrome p-450",
"pos": [
119,
135
]
} |
the induction of ae and of 7,8-benzoflavone-inhibitable ahh in 2sfou cells indicated that pb is capable of inducing cytochromes p-450 and cytochrome p-448 in the same cell . | NA | {
"id": "C0003927",
"name": "ahh",
"pos": [
56,
59
]
} | {
"id": "C0010762",
"name": "cytochromes p-450",
"pos": [
116,
133
]
} |
the bifunctional fluorinated nitrobenzenes , 1,5-difluoro-2,4-dinitrobenzene ( dfdnb ) and 4,4'-difluoro-3,3'-dinitrodiphenyl sulfone ( dfdndps ) , and the monofunctional 1-fluoro-2,4-dinitrobenzene ( fdnb ) inhibit chemotaxis , phagocytosis , exocytosis and the respiratory burst of rabbit polymorphonuclear leukocytes ... | NA | {
"id": "C0028145",
"name": "nitrobenzenes",
"pos": [
29,
42
]
} | {
"id": "C0012459",
"name": "dinitrobenzene",
"pos": [
184,
198
]
} |
thymidine was reacted in methanol with four epoxides of varying mutagenicities : propylene oxide , glycidol , epichlorohydrin and trichloropropylene oxide . | NA | {
"id": "C0014630",
"name": "epoxides",
"pos": [
44,
52
]
} | {
"id": "C0014486",
"name": "epichlorohydrin",
"pos": [
110,
125
]
} |
thymidine was reacted in methanol with four epoxides of varying mutagenicities : propylene oxide , glycidol , epichlorohydrin and trichloropropylene oxide . | NA | {
"id": "C0014630",
"name": "epoxides",
"pos": [
44,
52
]
} | {
"id": "C0040903",
"name": "trichloropropylene oxide",
"pos": [
130,
154
]
} |
however , both plasma and peritoneal fluid txb2 concentration were significantly reduced and accumulation of the toxic peptide , mdf , was significantly blunted ( 69 +/- 6 vs. 40 +/- 5 u/ml , p less than 0.01 ) . | NA | {
"id": "C0030956",
"name": "peptide",
"pos": [
119,
126
]
} | {
"id": "C0027047",
"name": "mdf",
"pos": [
129,
132
]
} |
blood pressure , heart rate , and plasma catecholamines were determined in conscious unanesthetized rats given intravenous saline or endotoxin ( lps from s. enteritidis ) . | NA | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
133,
142
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
145,
148
]
} |
the lethal action of endotoxin was studied in mice sensitized against the lipopolysaccharide by d-galactosamine . | NA | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
21,
30
]
} | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
74,
92
]
} |
the effects of temperature on naloxone treatment in canine hemorrhagic shock were examined in 24 dogs hemorrhaged to a mean arterial blood pressure of 35 mm hg ( ambient temperature , 21 degrees c ) . | NA | {
"id": "C0036982",
"name": "hemorrhagic shock",
"pos": [
59,
76
]
} | {
"id": "C0019080",
"name": "hemorrhaged",
"pos": [
102,
113
]
} |
in a double-blind controlled crossover trial of inhaled disodium cromoglycate and beclomethasone dipropionate in juvenile asthma , beclomethasone produced higher therapeutic scores but significantly so in only two indices -- wheeze-free days and morning peak flow rates . | NA | {
"id": "C0004906",
"name": "beclomethasone dipropionate",
"pos": [
82,
109
]
} | {
"id": "C0004905",
"name": "beclomethasone",
"pos": [
131,
145
]
} |
the two conditions occurred independently , the urticaria being associated with allergy to food ( which could be managed by control of the diet ) , whereas the angioedema was associated with c1 esterase inhibitor deficiency . | NA | {
"id": "C0042109",
"name": "urticaria",
"pos": [
48,
57
]
} | {
"id": "C0002994",
"name": "angioedema",
"pos": [
160,
170
]
} |
normal humans excrete about 1 mmol of alditols mostly as mannitol and 1 mmol of neutral sugars chiefly allulose in a 24-h period . | NA | {
"id": "C0038654",
"name": "alditols",
"pos": [
38,
46
]
} | {
"id": "C0024730",
"name": "mannitol",
"pos": [
57,
65
]
} |
we have synthesized a new substrate which may be useful in both the biochemical diagnosis of gm2 gangliosidosis and the detection of heterozygotes for the tay-sachs disease ( tsd ) allele . | NA | {
"id": "C0268274",
"name": "gm2 gangliosidosis",
"pos": [
93,
111
]
} | {
"id": "C0039373",
"name": "tay-sachs disease",
"pos": [
155,
172
]
} |
the fetal tissues are biologically responsive to igfs in vitro and are rich in specific cell membrane receptors , those predominantly recognizing igfi being structurally and functionally similar to the insulin receptor . | NA | {
"id": "C0037657",
"name": "igfs",
"pos": [
49,
53
]
} | {
"id": "C0021665",
"name": "igfi",
"pos": [
146,
150
]
} |
fetal igf production may be influenced by placental lactogen , especially igfii which rapidly declines in the circulation following parturition in the rat and sheep . | NA | {
"id": "C0037657",
"name": "igf",
"pos": [
6,
9
]
} | {
"id": "C0021666",
"name": "igfii",
"pos": [
74,
79
]
} |
in the last trimester insulin functions as a glucoregulatory hormone , but from much earlier in gestation creates an anabolic environment in the fetus supplied with optimal nutrients . | NA | {
"id": "C0032981",
"name": "last trimester",
"pos": [
7,
21
]
} | {
"id": "C0032961",
"name": "gestation",
"pos": [
96,
105
]
} |
before salicylate treatment , seven type ii diabetics had brisk increases ( mean +/- sem ) in circulating adrenaline ( time 0 = 50 +/- 7 pg/ml ; peak = 1630 +/- 330 pg/ml ) , noradrenaline ( time 0 = 260 +/- 46 pg/ml ; peak = 770 +/- 140 pg/ml ) , glucagon ( time 0 = 38 +/- 6 pg/ml ; peak = 75 +/- 10 pg/ml ) and pancre... | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
106,
116
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
175,
188
]
} |
the cells were challenged with the co precursor steroids ( all at 10 ( -5 ) mol/l ) pregnenolone ( pe ) , 17-hydroxy-pregnenolone ( 17-pe ) , progesterone ( po ) , 17-hydroxyprogesterone ( 17-po ) , 21-deoxycortisol ( 21-doc ) and 11-deoxycortisol ( 11-doc ) , or 1-24 adrenocorticotrophin ( acth , 100 ng/l ) in the pre... | NA | {
"id": "C0020387",
"name": "17-hydroxyprogesterone",
"pos": [
164,
186
]
} | {
"id": "C0033308",
"name": "po",
"pos": [
385,
387
]
} |
leukotriene d4 ( ltd4 ) , a constituent of slow-reacting substance of anaphylaxis ( srs-a ) , elicits a pressor response followed by prolonged hypotension in spontaneously hypertensive ( shr ) but not in wistar-kyoto ( wky ) rats . | NA | {
"id": "C0023544",
"name": "leukotriene d4",
"pos": [
0,
14
]
} | {
"id": "C0038091",
"name": "of slow-reacting substance",
"pos": [
40,
66
]
} |
9 alpha-fluorocortisol ( 9 alpha ff ) is an analogue of cortisol with 'mineralocorticoid ' , 'glucocorticoid ' and 'hypertensinogenic ' activity . | NA | {
"id": "C0016280",
"name": "9",
"pos": [
0,
1
]
} | {
"id": "C0020268",
"name": "cortisol",
"pos": [
56,
64
]
} |
premonitory symptoms may form part of a diffuse cerebral or hypothalamic disturbance preceding headache , while the prevalence of icecream headache and icepick-like pains suggests that pain pathways and neurovascular reflexes to sensory stimulation are hyperexcitable even between headache episodes . | NA | {
"id": "C0030193",
"name": "pain",
"pos": [
165,
169
]
} | {
"id": "C0018681",
"name": "headache",
"pos": [
281,
289
]
} |
normal macrophages release more pgi2 than pge2 and production of both these prostaglandins is stimulated equally by endotoxin ( lps ) . | NA | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
116,
125
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
128,
131
]
} |
monoclonal rheumatoid factors ( morf ) were prepared from autoimmune b6-lpr/lpr mice to investigate the influence of strain background on the specificity of these autoantibodies . | NA | {
"id": "C0035448",
"name": "rheumatoid factors",
"pos": [
11,
29
]
} | {
"id": "C0004358",
"name": "autoantibodies",
"pos": [
163,
177
]
} |
for the elderly , age is an insignificant factor for the elimination of isoniazid when compared with young adults of similar acetylator status , and the metabolism of rifampicin may be considered globally unaltered in this age group . | NA | {
"id": "C0221102",
"name": "elimination",
"pos": [
57,
68
]
} | {
"id": "C0025519",
"name": "metabolism",
"pos": [
153,
163
]
} |
amoxicillin-clavulanic acid is effective in treating both acute uncomplicated and complicated urinary-tract infections and exacerbations of chronic bronchitis caused by amoxicillin-resistant organisms in adults . | NA | {
"id": "C0054066",
"name": "amoxicillin-clavulanic acid",
"pos": [
0,
27
]
} | {
"id": "C0002645",
"name": "amoxicillin",
"pos": [
169,
180
]
} |
amoxicillin-clavulanic acid has also successfully cured urethritis in men caused by penicillinase-producing neisseria gonorrhoeae and is superior to amoxicillin alone for beta-lactamase-positive haemophilus ducreyi infections ( chancroid ) . | NA | {
"id": "C0054066",
"name": "amoxicillin-clavulanic acid",
"pos": [
0,
27
]
} | {
"id": "C0002645",
"name": "amoxicillin",
"pos": [
149,
160
]
} |
the half-life is 3-4 hours , and the predominant route of elimination is via renal excretion and tubular secretion . | NA | {
"id": "C1373186",
"name": "route of elimination",
"pos": [
49,
69
]
} | {
"id": "C1373187",
"name": "renal excretion",
"pos": [
77,
92
]
} |
carcinoids vary in their tendency to produce the carcinoid syndrome , although ileal tumors and those that have metastasized are more frequently associated with manifestations of the syndrome . | NA | {
"id": "C0007095",
"name": "carcinoids",
"pos": [
0,
10
]
} | {
"id": "C0024586",
"name": "carcinoid syndrome",
"pos": [
49,
67
]
} |
the further information that has accrued from the clinical studies reported so far would tend to support these early suggestions in that auranofin has compared very favourably with gold thiols and other disease-remittive agents and that the prevalence of side effects requiring withdrawal of therapy has been approximate... | NA | {
"id": "C0004320",
"name": "auranofin",
"pos": [
137,
146
]
} | {
"id": "C0018026",
"name": "gold",
"pos": [
181,
185
]
} |
in a review of over 3000 patients treated with auranofin , compared to 465 patients treated with injectable gold , the frequency of withdrawal from studies due to inefficacy of auranofin was approximately two to three times higher than with the gold thiols . | NA | {
"id": "C0004320",
"name": "auranofin",
"pos": [
47,
56
]
} | {
"id": "C0018026",
"name": "gold",
"pos": [
245,
249
]
} |
it would appear , therefore , that in those patients continuing on therapy , auranofin is similar to injectable gold , but that a higher proportion of patients will fail to get a response within three to six months to the therapy . | NA | {
"id": "C0004320",
"name": "auranofin",
"pos": [
77,
86
]
} | {
"id": "C0018026",
"name": "gold",
"pos": [
112,
116
]
} |
it is interesting to note that auranofin appears to be more potent and have different effects than gold thiols , despite the fact that in terms of clinical therapeutic profile the compounds are similar . | NA | {
"id": "C0004320",
"name": "auranofin",
"pos": [
31,
40
]
} | {
"id": "C0018026",
"name": "gold",
"pos": [
99,
103
]
} |
collagen biosynthesis by fibroblasts and subsequent processing and polymerization have been studied in conventional monolayer cultures and in a new model system in vitro in which cells organize into a tissue like structure . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
25,
36
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
179,
184
]
} |
four sugars other than sucrose ( maltose , fructose , glucose and lactose ) produced the depolarization or null responses and were accompanied by an increase or no change in membrane resistance . | NA | {
"id": "C0242209",
"name": "sugars",
"pos": [
5,
11
]
} | {
"id": "C0038636",
"name": "sucrose",
"pos": [
23,
30
]
} |
biochemical analysis of the different segments of the oviduct in the ovoviviparous salamander , salamandra salamandra , reveals the monosaccharides glucose , galactose , fucose , mannose , ribose and the hexosamines glucosamine and mannosamine . | NA | {
"id": "C0019478",
"name": "hexosamines",
"pos": [
204,
215
]
} | {
"id": "C0017718",
"name": "glucosamine",
"pos": [
216,
227
]
} |
both the mitochondrial and microsomal fractions contained significant proportions of solvent front phospholipid ( sfp ) and whereas the mitochondrial sfp displayed the relatively unsaturated fatty acid composition characteristic of diphosphatidylglycerol ( cardiolipin ) , the fatty acids of the microsomal sfp were dist... | NA | {
"id": "C0015690",
"name": "unsaturated fatty acid",
"pos": [
179,
201
]
} | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
277,
288
]
} |
in both strains , cholesterol feeding caused elevations of cholesterol in all lipoprotein classes , the difference between the hypo- and hyperresponsive strains in essence only being observed in the vldl ( very low density lipoprotein ) fraction . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
78,
89
]
} | {
"id": "C0023825",
"name": "very low density",
"pos": [
206,
222
]
} |
when the concentration of one of these cations was varied around its physiological concentration , the enzyme activity was relatively stable , indicating that the intracellular amp deaminase activity would be insensitive to changes in the concentrations of monovalent cations . | NA | {
"id": "C0007447",
"name": "cations",
"pos": [
39,
46
]
} | {
"id": "C0007449",
"name": "monovalent cations",
"pos": [
257,
275
]
} |
concomitant administration of alpha-tocopherol acetate in both normal and vitamin e-deficient rats depressed markedly the enhanced lipid synthesis and aggregation induced by estrogen . | NA | {
"id": "C1999896",
"name": "alpha-tocopherol",
"pos": [
30,
46
]
} | {
"id": "C0042874",
"name": "vitamin e",
"pos": [
74,
83
]
} |
this review focuses on measurement techniques for aspartate aminotransferase and their application ( a subsequent article will review other aminotransferases ) . | NA | {
"id": "C0004002",
"name": "aspartate aminotransferase",
"pos": [
50,
76
]
} | {
"id": "C0002594",
"name": "aminotransferases",
"pos": [
140,
157
]
} |
a range of milk-derived protein preparations , i.e. , dry milk , milk proteins , caseins , whey proteins , and lactalbumin , are used in a range of food products for their specific functional attributes . | NA | {
"id": "C0026138",
"name": "milk",
"pos": [
11,
15
]
} | {
"id": "C0007332",
"name": "caseins",
"pos": [
81,
88
]
} |
a range of milk-derived protein preparations , i.e. , dry milk , milk proteins , caseins , whey proteins , and lactalbumin , are used in a range of food products for their specific functional attributes . | NA | {
"id": "C0026138",
"name": "milk",
"pos": [
11,
15
]
} | {
"id": "C0078479",
"name": "whey proteins",
"pos": [
91,
104
]
} |
knowledge of the molecular properties of plant proteins is essential to understand the basis of protein functionality , to modify proteins so that they acquire desirable functional properties , and to predict potential applications of modified plant proteins . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
47,
55
]
} | {
"id": "C0032089",
"name": "plant proteins",
"pos": [
244,
258
]
} |
fatty acid composition of phospholipids and free fatty acids were analyzed in the epithelium , stroma and endothelium of rabbit corneas . | NA | {
"id": "C0015684",
"name": "fatty acid",
"pos": [
0,
10
]
} | {
"id": "C0015688",
"name": "free fatty acids",
"pos": [
44,
60
]
} |
we have mapped the albumin locus ( alb ) in the owl monkey , aotus trivirgatus , using a cloned human albumin gene probe , pchsa 33-1 . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
19,
26
]
} | {
"id": "C0304925",
"name": "human albumin",
"pos": [
96,
109
]
} |
somatic cell hybrids between her fibroblasts and hprt-deficient chinese hamster cells were obtained and selected for and against retention of the active human x chromosome . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
33,
44
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
80,
85
]
} |
depressive disorder in children and adolescents : dysthymic disorder and the use of self-rating scales in assessment . | NA | {
"id": "C0011581",
"name": "depressive disorder",
"pos": [
0,
19
]
} | {
"id": "C0013415",
"name": "dysthymic disorder",
"pos": [
50,
68
]
} |
in a comparison with pediatric patients with head injury only ( coma greater than 6 h , no multiple trauma ) there was found to be a 12 % mortality in the head injury only group versus a 33 % mortality in the multiple trauma plus head injury group . | NA | {
"id": "C0026771",
"name": "multiple trauma",
"pos": [
91,
106
]
} | {
"id": "C0043251",
"name": "trauma",
"pos": [
218,
224
]
} |
a deoxyribonuclease derived from epstein-barr virus ( ebv ) -producing lymphoblastoid cell line ( npc-204 cells ) treated with iudr was purified by deae cellulose , phospho-cellulose , and dna-cellulose columns with 45 % recovery . | NA | {
"id": "C0011050",
"name": "deae",
"pos": [
148,
152
]
} | {
"id": "C0007648",
"name": "cellulose",
"pos": [
193,
202
]
} |
basing on long experience the following indications for this technique have been developed : fresh fractures a deux etages , comminuted and compression fractures of long tubular bones that were stabilized operatively by plate-osteosynthesis showing smaller or bigger osseous defects , furthermore basic defects of the ac... | NA | {
"id": "C0476171",
"name": "comminuted",
"pos": [
125,
135
]
} | {
"id": "C0016658",
"name": "fractures of",
"pos": [
152,
164
]
} |
the isolated lenticular plasma membrane-cytoskeleton complex , when analysed by sodium dodecylsulphate-polyacrylamide gel electrophoresis , shows reproducibly a significant amount of crystallins , mainly alpha-crystallin . | NA | {
"id": "C0010422",
"name": "crystallins",
"pos": [
183,
194
]
} | {
"id": "C0002257",
"name": "alpha-crystallin",
"pos": [
204,
220
]
} |
the formation of hmw proteins in x-ray-induced cataracts through disulphide bond formation and the involvement of sh oxidation in hmw proteins isolated from human cataractous lenses suggest a role for gsh in protecting protein sh groups . | NA | {
"id": "C0034861",
"name": "formation",
"pos": [
4,
13
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
219,
226
]
} |
patients in the lowest social class ( v ) were in a higher risk group , experiencing ketoacidosis more often and having a higher frequency of severe acidosis . | NA | {
"id": "C0022638",
"name": "ketoacidosis",
"pos": [
85,
97
]
} | {
"id": "C0001122",
"name": "acidosis",
"pos": [
149,
157
]
} |
no deleterious sulfonylurea effects on cholesterol , ldl cholesterol , and triglyceride concentrations or hdl cholesterol/total cholesterol ratio were noted . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
39,
50
]
} | {
"id": "C0023824",
"name": "ldl cholesterol",
"pos": [
53,
68
]
} |
delayed vep responses are not confined to optic neuritis ( rbn ) alone and the different latency times obtained from other on are confluent . | NA | {
"id": "C0029134",
"name": "optic neuritis",
"pos": [
42,
56
]
} | {
"id": "C0029132",
"name": "on",
"pos": [
131,
133
]
} |
the metabolism , excretion , and pharmacokinetics of [ 15,16-3h2 ] naltrexone were studied in six human males after sc administration of the hydrochloride salt . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
4,
14
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
17,
26
]
} |
fecal elimination was the primary route of excretion of the drug in rats and mice after oral dosing . | NA | {
"id": "C1373190",
"name": "fecal",
"pos": [
0,
5
]
} | {
"id": "C1373186",
"name": "route of excretion",
"pos": [
34,
52
]
} |
the disappearance of tocp from the plasma followed a monoexponential kinetics with a half-life of 1.2 days . | NA | {
"id": "C0022702",
"name": "kinetics",
"pos": [
69,
77
]
} | {
"id": "C0018517",
"name": "half-life",
"pos": [
85,
94
]
} |
acute intravascular hemolysis developed when a diabetic patient , previously treated with glyburide , was started on another oral sulfonylurea drug , chlorpropamide . | NA | {
"id": "C0017628",
"name": "glyburide",
"pos": [
90,
99
]
} | {
"id": "C0038766",
"name": "sulfonylurea",
"pos": [
130,
142
]
} |
to test the effects on the humoral immune response sheep erythrocytes were injected , and the antiserum titer in blood and the portion of antibody forming cells in spleen were measured . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
94,
103
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
138,
146
]
} |
the general conclusions were : ( 1 ) the organophosphates ( fenamiphos and fensulfothion ) and the carbamate ( aldicarb ) were the most toxic of the insecticides tested . | NA | {
"id": "C0006948",
"name": "carbamate",
"pos": [
99,
108
]
} | {
"id": "C0001994",
"name": "aldicarb",
"pos": [
111,
119
]
} |
monoclonal antibodies did not react with cells of blood and bone marrow from healthy people and from patients with chronic lymphocytic leukemia , acute myeloblastic leukemia , acute myelomonocytic leukemia , acute monoblastic leukemia and lymphosarcoma . | NA | {
"id": "C0023467",
"name": "acute myeloblastic leukemia",
"pos": [
146,
173
]
} | {
"id": "C0023465",
"name": "acute",
"pos": [
208,
213
]
} |
the present study was undertaken in order to describe 16 more patients suffering from startle-induced epileptic seizures and to clarify further the possible therapeutic activity of benzodiazepines in this rare reflex epilepsy . | NA | {
"id": "C0014544",
"name": "epileptic seizures",
"pos": [
102,
120
]
} | {
"id": "C0270857",
"name": "reflex epilepsy",
"pos": [
210,
225
]
} |
the role of alumina cream ( ac ) epileptic granulomas in producing clinical convulsions and eeg spikes was evaluated by excising and transplanting such granulomas from donors to recipient cats . | NA | {
"id": "C0014544",
"name": "epileptic",
"pos": [
33,
42
]
} | {
"id": "C0036572",
"name": "convulsions",
"pos": [
76,
87
]
} |
diphenylhydantoin ( phenytoin ) added to cultures of osteoblast-like cells at a concentration of 10 microm , at the high end of the therapeutic range in plasma of unbound phenytoin ( 4-8 microm ) , caused reductions in na+ , k+-atpase and alkaline phosphatase activities and increases in ca2+-atpase and hco3 -- atpase a... | NA | {
"id": "C0001473",
"name": "atpase",
"pos": [
228,
234
]
} | {
"id": "C0001476",
"name": "ca2",
"pos": [
288,
291
]
} |
msh dust , na feldspar , cristobalite , and alpha-quartz , in concentrations of 0.4 to 40 mg/ml , had neither significant effects on mucin release by tracheal explants nor acute toxic effects after exposure for 2 hr . | NA | {
"id": "C0037098",
"name": "cristobalite",
"pos": [
25,
37
]
} | {
"id": "C0034387",
"name": "quartz",
"pos": [
50,
56
]
} |
in contrast , long-term exposure to na feldspar , cristobalite , and alpha-quartz caused significant toxicity to the explants , although metaplastic changes were not observed . | NA | {
"id": "C0037098",
"name": "cristobalite",
"pos": [
50,
62
]
} | {
"id": "C0034387",
"name": "quartz",
"pos": [
75,
81
]
} |
enzyme activity levels were elevated by 3.2- to 3.5-fold in transformed cells compared directly to the normal human fibroblast strains from which they were derived . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
72,
77
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
116,
126
]
} |
screening genomic libraries , cloned in phage lambda or cosmid vectors , with this isolated dna yielded a series of overlapping dna fragments from the region 93d6-7 as shown by in situ hybridization to polytene chromosomes . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
92,
95
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
193,
194
]
} |
plasma norepinephrine , epinephrine , glucagon , and serum cortisol concentrations were not significantly affected by the leg change . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
7,
21
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
24,
35
]
} |
structural studies on the lipid a component of enterobacterial lipopolysaccharides by laser desorption mass spectrometry . | NA | {
"id": "C0023767",
"name": "lipid a",
"pos": [
26,
33
]
} | {
"id": "C0023810",
"name": "lipopolysaccharides",
"pos": [
63,
82
]
} |
the haemodynamic response to two xanthines , enprofylline and theophylline , was studied in 6 healthy male volunteers at rest , during exercise and in combination with the beta 2-agonist , terbutaline . | NA | {
"id": "C0043318",
"name": "xanthines",
"pos": [
33,
42
]
} | {
"id": "C0039771",
"name": "theophylline",
"pos": [
62,
74
]
} |
anxiolytic benzodiazepines inhibit locus coeruleus activity and previous data showed that chlordiazepoxide was capable of antagonizing the locus coeruleus-mediated suppression of muricidal aggression . | NA | {
"id": "C0005064",
"name": "benzodiazepines",
"pos": [
11,
26
]
} | {
"id": "C0008188",
"name": "chlordiazepoxide",
"pos": [
90,
106
]
} |
the effects of pge on progenitor cell ia-antigen expression appear specific for prostaglandins of the e series ( pge1 , pge2 ) and do not appear to be mediated via cyclic amp . | NA | {
"id": "C0033559",
"name": "prostaglandins",
"pos": [
80,
94
]
} | {
"id": "C0012472",
"name": "pge2",
"pos": [
120,
124
]
} |
these data appear to explain the hemopoietic recovery seen in man after transplantation with marrow cells treated with 4-hc despite their relative absence of hemopoietic progenitor cells . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
100,
105
]
} | {
"id": "C0018956",
"name": "hemopoietic progenitor cells",
"pos": [
158,
186
]
} |
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