text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
in this study scanning electron microscopy ( sem ) was used to investigate the substrate attachment , cell spreading and growth properties of fibroblasts and epithelioid cells on a newly developed machinable bioactive glass ceramic . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
102,
106
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
142,
153
]
} |
these results suggest that chronic ethanol feeding causes pancreatic cholesteryl ester accumulation by affecting exchange of cholesterol between serum and pancreatic tissue . | NA | {
"id": "C0008387",
"name": "cholesteryl ester",
"pos": [
69,
86
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
125,
136
]
} |
data are presented indicating that both exogenous catecholamines ( i.e. , isoproterenol ) and endogenous catecholamines ( released from tyramine ) are able to bring about a degree of myocardial hypertrophy associated with a significant increase in the ventricular concentrations of hydroxyproline , without affecting hem... | NA | {
"id": "C0022245",
"name": "isoproterenol",
"pos": [
74,
87
]
} | {
"id": "C0007412",
"name": "catecholamines",
"pos": [
105,
119
]
} |
metformin did not significantly change postprandial blood glucose , haemoglobin a1c and urinary glucose excretion with the prescribed dose . | NA | {
"id": "C0005802",
"name": "blood glucose",
"pos": [
52,
65
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
96,
103
]
} |
the differences between 31 gi-subjects , with low hba1 ( mean 6.9 % ) , and 20 gi-subjects , with relatively high hba1 ( mean 7.9 % ) , were not significant with respect to fasting and 2-hour blood glucose , area under glucose curve , body mass index , index of physical activity , rate of hypertension or rate of first ... | NA | {
"id": "C0005802",
"name": "blood glucose",
"pos": [
192,
205
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
219,
226
]
} |
recombinant bovine growth hormone , human growth hormone , ovine growth hormone and recombinant porcine growth hormone competed effectively with 125i-labeled recombinant bovine growth hormone for binding sites , while bovine prolactin and ovine prolactin were needed in amounts 10 ( 6 ) -fold the concentration of recomb... | NA | {
"id": "C0169964",
"name": "human growth hormone",
"pos": [
36,
56
]
} | {
"id": "C0037663",
"name": "growth hormone",
"pos": [
333,
347
]
} |
to discover if these alterations are linked to a genetic defect of the v1 receptor , we have studied the binding of vp on liver and kidney membranes of two other models , female diabetic mice c57 bl-6 orl db/db ( db/db mice ) and female zucker rats fatty/orl fa/fa ( fa/fa rats ) , which exhibit different temporal patte... | NA | {
"id": "C0020459",
"name": "hyperinsulinemia",
"pos": [
336,
352
]
} | {
"id": "C0021655",
"name": "insulin resistance",
"pos": [
357,
375
]
} |
these results suggest that the specific alteration in liver vp receptors is not related to a defect in v1 receptor genetic expression but is specific for liver and appears to parallel the level of hyperinsulinemia and/or insulin resistance . | NA | {
"id": "C0020459",
"name": "hyperinsulinemia",
"pos": [
197,
213
]
} | {
"id": "C0021655",
"name": "insulin resistance",
"pos": [
221,
239
]
} |
aliquots of the eluates were incubated with a c-terminal glucagon antiserum ( 30k ) and the radioactivity bound to the glucagon antibody appeared to be distributed among proteins of molecular weight greater than 40.14 and 3.5 kdaltons . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
66,
75
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
128,
136
]
} |
cells were cultured in dulbecco 's modified medium containing 1 % bovine serum albumin , which did not permit fibroblast outgrowth . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
0,
5
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
110,
120
]
} |
among a variety of different hormones tested , the most potent growth promoters were found to be the corticosteroids whose potency was related to their glucocorticoid activity . | NA | {
"id": "C0019932",
"name": "hormones",
"pos": [
29,
37
]
} | {
"id": "C0001617",
"name": "corticosteroids",
"pos": [
101,
116
]
} |
vasodilator drugs are generally classified according to their prevalent site of action : arteriolar vasodilators ( e.g . phentolamine , hydralazine , nifedipine ) which reduce peripheral resistance and , therefore , increase stroke volume and cardiac output ; | NA | {
"id": "C2267010",
"name": "arteriolar vasodilators",
"pos": [
89,
112
]
} | {
"id": "C0020223",
"name": "hydralazine",
"pos": [
136,
147
]
} |
tumors induced by captafol were , histologically , hemangioendothelioma in the heart , hemangioma or hemangioendothelioma in the spleen , papilloma and squamous cell carcinoma in the forestomach , adenoma and adenocarcinoma in the small intestine , and hyperplastic nodule and hepatocellular carcinoma in the liver . | NA | {
"id": "C0018916",
"name": "hemangioma",
"pos": [
87,
97
]
} | {
"id": "C0018915",
"name": "hemangioendothelioma",
"pos": [
101,
121
]
} |
it is noteworthy that only bile acids of the same metabolic pathway , ca as a primary bile acid and dca as a secondary bile acid , showed promoting effects whereas cdca and its metabolic derivatives , lca and udca , were inactive . | NA | {
"id": "C0011479",
"name": "dca",
"pos": [
100,
103
]
} | {
"id": "C0008024",
"name": "cdca",
"pos": [
164,
168
]
} |
it is noteworthy that only bile acids of the same metabolic pathway , ca as a primary bile acid and dca as a secondary bile acid , showed promoting effects whereas cdca and its metabolic derivatives , lca and udca , were inactive . | NA | {
"id": "C0011479",
"name": "dca",
"pos": [
100,
103
]
} | {
"id": "C0042105",
"name": "udca",
"pos": [
209,
213
]
} |
the concentrations of the barbiturates used were : barbitone 3.1 x 10 ( -2 ) m , phenobarbitone 3.15 x 10 ( -3 ) m , pentobarbitone 6.04 x 10 ( -4 ) m , thiopentone 1.89 x 10 ( -4 ) m . | NA | {
"id": "C0004745",
"name": "barbiturates",
"pos": [
26,
38
]
} | {
"id": "C0004743",
"name": "barbitone",
"pos": [
122,
131
]
} |
the concentrations of the barbiturates used were : barbitone 3.1 x 10 ( -2 ) m , phenobarbitone 3.15 x 10 ( -3 ) m , pentobarbitone 6.04 x 10 ( -4 ) m , thiopentone 1.89 x 10 ( -4 ) m . | NA | {
"id": "C0004745",
"name": "barbiturates",
"pos": [
26,
38
]
} | {
"id": "C0030883",
"name": "pentobarbitone",
"pos": [
117,
131
]
} |
serum progesterone concentration increased ( 37.2 +/- 15.6 to 119.2 +/- 34.6 ng/dl , p less than 0.01 ) whereas serum 17-hydroxyprogesterone concentration declined after bile duct ligation suggesting the development of a 17-hydroxylase enzymatic block . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
6,
18
]
} | {
"id": "C0020387",
"name": "17-hydroxyprogesterone",
"pos": [
118,
140
]
} |
comparative effects of somatostatin-28 and somatostatin-14 on basal growth hormone release and pancreatic function in immature ducks ( anas platyrhynchos ) . | NA | {
"id": "C0074854",
"name": "somatostatin-28",
"pos": [
23,
38
]
} | {
"id": "C0037659",
"name": "somatostatin-14",
"pos": [
43,
58
]
} |
the ss dna template is annealed with a universal sequencing primer , the primer extended with dna polymerase i klenow fragment and the dna duplex cut at a unique site 5 ' to the multiple cloning sites in the m13 phage . | NA | {
"id": "C0012935",
"name": "ss dna",
"pos": [
4,
10
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
135,
138
]
} |
cultured chick embryonal retinal pigment epithelial ( rpe ) cells synthesized two main glycosaminoglycans ( gags ) , chondroitin 4-sulfate , and heparan sulfate . | NA | {
"id": "C0017973",
"name": "glycosaminoglycans",
"pos": [
87,
105
]
} | {
"id": "C0019143",
"name": "heparan sulfate",
"pos": [
145,
160
]
} |
glycosaminoglycans liberated into the medium were composed of chondroitin 4-sulfate ( 44 % ) , keratan sulfate ( 22 % ) , heparan sulfate ( 18 % ) and hyaluronate ( 12 % ) . | NA | {
"id": "C0017973",
"name": "glycosaminoglycans",
"pos": [
0,
18
]
} | {
"id": "C0019143",
"name": "heparan sulfate",
"pos": [
122,
137
]
} |
on the other hand , the gags in the cell and/or basement membrane were composed of heparan sulfate ( 52 % ) , hyaluronate ( 19 % ) , and chondroitin 4-sulfate ( 13 % ) . | NA | {
"id": "C0017973",
"name": "gags",
"pos": [
24,
28
]
} | {
"id": "C0019143",
"name": "heparan sulfate",
"pos": [
83,
98
]
} |
during pregnancy it was significantly higher ( 1.48 +/- 0.31 , 1.91 +/- 0.25 and 2.20 +/- 0.36 mg/l during the 1st , 2nd and 3rd trimesters , respectively ) and 5 weeks postpartum it was still higher ( 1.09 +/- 0.17 mg/l ) than in the nonpregnant women . | NA | {
"id": "C0032961",
"name": "pregnancy",
"pos": [
7,
16
]
} | {
"id": "C0032981",
"name": "3rd trimesters",
"pos": [
125,
139
]
} |
the pressor responses of norepinephrine , epinephrine and tyramine were potentiated by pretreatment with oxybutynin ( 15 mg/kg , i.v . ) . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
25,
39
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
42,
53
]
} |
in the present study , we examined the urine of rats subjected to freeze ulceration of the bladder and then fed sodium saccharin at 5 % in the diet to evaluate the possibility of a mutagen being generated as a result of ulceration and/or saccharin feeding . | NA | {
"id": "C0917900",
"name": "sodium saccharin",
"pos": [
112,
128
]
} | {
"id": "C0036023",
"name": "saccharin",
"pos": [
238,
247
]
} |
half the total plasma activity was associated with lipoproteins , and more than 90 per cent of the residue activity with macromolecular lipid-protein complex . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
51,
63
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
136,
141
]
} |
in cholestasis , ggt activity increased mainly by the following two mechanisms : 1 ) the appearance of cholestatic lipoproteins carrying ggt , such as lipoprotein x or slow-migrating hdl , or increase in concentration of lipid-protein complex with ggt activity and 2 ) increase in ggt activity per unit weight of hdl . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
115,
127
]
} | {
"id": "C0023819",
"name": "lipoprotein x",
"pos": [
151,
164
]
} |
early antigens ( ea ) were readily synthesized at a low multiplicity of infection ( moi ) , whereas synthesis of the 2 late antigens , virus capsid antigen ( vca ) and membrane antigen ( ma ) was induced only at a high moi . | NA | {
"id": "C0003342",
"name": "virus",
"pos": [
135,
140
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
177,
184
]
} |
vca was induced following three-hit kinetics , suggesting that 3 times the amount of the infecting virus is required for the induction of the antigen . | NA | {
"id": "C0003342",
"name": "vca",
"pos": [
0,
3
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
142,
149
]
} |
previous data of lipid and lipoprotein level changes with the application of danazol , an isoxazol derivative of 17-alpha-ethinyl testosterone , have been conflicting . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
17,
22
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
27,
38
]
} |
therefore , we used molt 4 receptor to evaluate the effect of the sulfonylurea glipizide on insulin binding . | NA | {
"id": "C0038766",
"name": "sulfonylurea",
"pos": [
66,
78
]
} | {
"id": "C0017642",
"name": "glipizide",
"pos": [
79,
88
]
} |
the hormone possessed weak activity alone ( minimal responsive dose = 1 u ) , but was able to potentiate the acth-stimulated corticoid release at much lower doses ( significant response over acth alone at 0.01 u prolactin ) . | NA | {
"id": "C0019932",
"name": "hormone",
"pos": [
4,
11
]
} | {
"id": "C0001617",
"name": "corticoid",
"pos": [
125,
134
]
} |
when the gssg : total gsh ratio was increased by culturing the cells in 0.5 mm diamide , butylhydroperoxide , or 10 ( -5 ) m vinblastine , 5'-deiodination was decreased . | NA | {
"id": "C0061516",
"name": "gssg",
"pos": [
9,
13
]
} | {
"id": "C0017817",
"name": "gsh",
"pos": [
22,
25
]
} |
in fetal mouse liver explants , 5'-deiodination and total gsh were decreased but the gssg ratio was normal and the deiodinase vmax was decreased . | NA | {
"id": "C0017817",
"name": "gsh",
"pos": [
58,
61
]
} | {
"id": "C0061516",
"name": "gssg",
"pos": [
85,
89
]
} |
it is concluded that monodeiodinase activity in hepatocytes is not regulated by the total gsh concentration but is inversely correlated with the ratio of gssg to total gsh . | NA | {
"id": "C0061516",
"name": "gssg",
"pos": [
154,
158
]
} | {
"id": "C0017817",
"name": "gsh",
"pos": [
168,
171
]
} |
the majority of cells examined from amniocyte , fibroblast , and lymphocyte cultures contained an asymmetrical dicentric ring 21 chromosome which was larger than a normal chromosome 21 . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
0,
3
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
48,
58
]
} |
frequency of diarrhoea was 3 times as high in the ampicillin group as in the bacampicillin group . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
50,
60
]
} | {
"id": "C0052865",
"name": "group",
"pos": [
91,
96
]
} |
the sensitivity of induced cells to binding and lysis by non-sensitized peripheral blood mononuclear cells ( mnc ) in agarose was studied in relation to the target cell division rate . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
0,
3
]
} | {
"id": "C1321301",
"name": "peripheral",
"pos": [
72,
82
]
} |
activation of probable proinsulin-converting enzymes in pancreatic islets : its correlationship with rate of insulin biosynthesis . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
23,
33
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
109,
116
]
} |
a fourth molecule , fa , was identified by a novel monoclonal antibody and was also detected by two additional antibodies , tu39 and sg171 , that blocked the sb-specific t-cell proliferative response . | NA | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
51,
70
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
111,
121
]
} |
glutamate dehydrogenase ( gdh ) and the transaminases namely aspartate aminotransferase ( aat ) and alanine aminotransferase ( aiat ) were estimated in the muscle , liver , kidney , and brain of control and ammonium acetate administered frogs . | NA | {
"id": "C0002594",
"name": "transaminases",
"pos": [
40,
53
]
} | {
"id": "C0004002",
"name": "aspartate",
"pos": [
61,
70
]
} |
glutamate dehydrogenase ( gdh ) and the transaminases namely aspartate aminotransferase ( aat ) and alanine aminotransferase ( aiat ) were estimated in the muscle , liver , kidney , and brain of control and ammonium acetate administered frogs . | NA | {
"id": "C0002594",
"name": "transaminases",
"pos": [
40,
53
]
} | {
"id": "C0001899",
"name": "alanine aminotransferase",
"pos": [
100,
124
]
} |
parachloromercury benzoate ( pcmb ) , a sulphydryl inactivator , caused a progressively increasing inhibition of tissue responses to acetylcholine , adrenaline , noradrenaline and serotonin in vitro . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
149,
159
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
162,
175
]
} |
unilateral-sciatectomy for three months in the frog , rana cyanophlictis resulted in a substantial increase on unit weight basis in the ascorbic acid ( asa ) and dehydroascorbic acid ( dha ) contents of the sciatectomized gastrocnemius muscle . | NA | {
"id": "C0003968",
"name": "ascorbic acid",
"pos": [
136,
149
]
} | {
"id": "C0011177",
"name": "dehydroascorbic acid",
"pos": [
162,
182
]
} |
a controlled open clinical trial was carried out to compare the peripheral venous tolerance of patients receiving a hyperosmolar basic nutrition solution ( 3 % amino acids , carbohydrates and electrolytes , 806 mosm/l ) with that of patients receiving an isoosmolar electrolyte solution ( 299 mosm/l ) . | NA | {
"id": "C0013832",
"name": "electrolytes",
"pos": [
192,
204
]
} | {
"id": "C0308944",
"name": "electrolyte solution",
"pos": [
266,
286
]
} |
effect of lipopolysaccharides , lipid a and interferon on the cell-mediated cytotoxicity of human leukocytes against k-562 tumor cells . | NA | {
"id": "C0023810",
"name": "lipopolysaccharides",
"pos": [
10,
29
]
} | {
"id": "C0023767",
"name": "lipid a",
"pos": [
32,
39
]
} |
the effect of lipopolysaccharides ( lps ) , lipid a and interferon on cell-mediated cytotoxicity was investigated using 51cr-labeled k-562 tumor cells as targets . | NA | {
"id": "C0023810",
"name": "lipopolysaccharides",
"pos": [
14,
33
]
} | {
"id": "C0023767",
"name": "lipid a",
"pos": [
44,
51
]
} |
supernatants from lps-treated mononuclear phagocytes and t cells enhanced mononuclear phagocyte-mediated cytotoxicity to a higher degree than lps and lipid a alone . | NA | {
"id": "C0023810",
"name": "lps",
"pos": [
18,
21
]
} | {
"id": "C0023767",
"name": "lipid a",
"pos": [
150,
157
]
} |
the urine samples were specified with respect to the following parameters : sampling period , volume , urine status , density , creatinine , noradrenaline , and adrenaline . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
141,
154
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
161,
171
]
} |
the efficacy of beta-carotene as an inhibitor of micronucleated cell formation , the lack of toxicity , and its availability from a multitude of dietary sources should focus attention on this carotenoid as a promising chemopreventive agent . | NA | {
"id": "C0053396",
"name": "beta-carotene",
"pos": [
16,
29
]
} | {
"id": "C0007271",
"name": "carotenoid",
"pos": [
192,
202
]
} |
a panel of human malignant and non-malignant cells consisting of erythroleukemia , melanoma and carcinomas of breast , cervix , larynx , nasopharynx and colon , as well as human fibroblasts and mammary cells , were tested using a sensitive enzyme-linked immunoassay . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
178,
189
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
202,
207
]
} |
in particular , a history of lack of positive alcohol effects and social maladjustment were typical of high-aggressive distilled alcohol and alcohol-placebo subjects , while the presence of family problems and anxiety typified high-aggressive beer and placebo-beer subjects . | NA | {
"id": "C0001962",
"name": "alcohol",
"pos": [
46,
53
]
} | {
"id": "C0004922",
"name": "beer",
"pos": [
260,
264
]
} |
the effect of n-acetyl-d-glucosamine ( nag ) on in vitro stimulated human peripheral blood lymphocytes was investigated . | NA | {
"id": "C0017718",
"name": "glucosamine",
"pos": [
25,
36
]
} | {
"id": "C0001056",
"name": "nag",
"pos": [
39,
42
]
} |
the other is intraepithelial neoplasia , which , like classical infection , may be mature [ cervical intraepithelial neoplasia ( cin ) with koilocytosis ] or immature ( high grade cin or carcinoma in situ ) . | NA | {
"id": "C0206708",
"name": "cervical intraepithelial neoplasia",
"pos": [
92,
126
]
} | {
"id": "C0007099",
"name": "carcinoma in situ",
"pos": [
187,
204
]
} |
after controlling for the effects of differences in age , weight , physical work capacity and initial values in risk factors , and for changes in physical work capacity , weight change in women was found to account independently for a proportion of the variance of changes in systolic blood pressure ( 3 per cent ) , dia... | NA | {
"id": "C0005910",
"name": "weight",
"pos": [
58,
64
]
} | {
"id": "C0005911",
"name": "weight change in",
"pos": [
171,
187
]
} |
the results are interpreted in terms of the thioamide ( amide ) function in receptor recognition processes , the probable behavior of thiopeptides toward physiologically relevant peptidases and the structural divergences between tissue-specific receptors . | NA | {
"id": "C0039875",
"name": "thioamide",
"pos": [
44,
53
]
} | {
"id": "C0002482",
"name": "amide",
"pos": [
56,
61
]
} |
all derivatives were activated normally by prothrombinase ( the activating complex of factor xa , factor v ( a ) , ca2+ and phospholipids ) , as indicated by the pattern of bands on sds gel electrophoresis and an unaltered yield of activity toward a chromogenic substrate for thrombin . | NA | {
"id": "C0015518",
"name": "prothrombinase",
"pos": [
43,
57
]
} | {
"id": "C0015520",
"name": "factor xa",
"pos": [
86,
95
]
} |
use is made of the concept of differing and conflicting aspects of the self-representation to elucidate the particular nature of these patients ' bisexual fantasies , which allowed appropriate sexual gender and role to develop , and yet which , at times , also permitted drive gratification associated with the fantasy o... | NA | {
"id": "C0079399",
"name": "gender",
"pos": [
200,
206
]
} | {
"id": "C0086582",
"name": "male",
"pos": [
328,
332
]
} |
heteroduplex deoxyribonucleic acid ( dna ) molecules were formed in vitro by denaturing and renaturing a mixture of dnas from a variety of lambda strains . | NA | {
"id": "C0012854",
"name": "deoxyribonucleic acid",
"pos": [
13,
34
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
149,
150
]
} |
purification of ovalbumin messenger ribonucleic acid by specific immunoadsorption of ovalbumin-synthesizing polysomes and millipore partition of ribonucleic acid . | NA | {
"id": "C0035696",
"name": "messenger ribonucleic acid",
"pos": [
26,
52
]
} | {
"id": "C0035668",
"name": "ribonucleic acid",
"pos": [
145,
161
]
} |
formation of cyclic adenosine 3',5'-monophosphate from endogenous adenosine triphosphate and from radioactive adenosine triphosphate formed during a prior incubation with radioactive adenine . | NA | {
"id": "C0001413",
"name": "5",
"pos": [
33,
34
]
} | {
"id": "C0001480",
"name": "adenosine triphosphate",
"pos": [
110,
132
]
} |
however , combined therapy using penicillin g or ampicillin with streptomycin was always effective in prophylaxis . | NA | {
"id": "C0030827",
"name": "penicillin g",
"pos": [
33,
45
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
49,
59
]
} |
alpha keto-analogues of valine , leucine , isoleucine , methionine , phenylalanine , and ( in one instance ) tryptophan and histidine , along with the remaining essential amino acids , were administered orally to 10 patients with severe chronic uremia fed a diet low in protein but adequate in calories . | NA | {
"id": "C0025646",
"name": "methionine",
"pos": [
56,
66
]
} | {
"id": "C0002525",
"name": "essential amino acids",
"pos": [
161,
182
]
} |
the unique action of cholera enterotoxin on cyclic amp production provides a potentially useful pharmacologic tool , in addition to methylxanthines and dibutyryl cyclic amp , for testing hypotheses relating cyclic amp to altered function of leukocytes and , perhaps , of other mammalian cells . | NA | {
"id": "C0012054",
"name": "dibutyryl cyclic amp",
"pos": [
152,
172
]
} | {
"id": "C0001455",
"name": "cyclic amp",
"pos": [
207,
217
]
} |
the present investigation was undertaken to observe the effect on 24-h triglyceride , free fatty acid , blood sugar , and plasma insulin profiles of inhibition of nocturnal lipolysis by glucose or nicotinic acid in normal subjects and in patients with type iv hyperlipoproteinemia . | NA | {
"id": "C0005802",
"name": "blood sugar",
"pos": [
104,
115
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
186,
193
]
} |
a comparison of intramuscular ergometrine maleate and oxytocin with intravenous oxytocin and intramuscular ergometrine in the third stage of labour . | NA | {
"id": "C0059514",
"name": "ergometrine maleate",
"pos": [
30,
49
]
} | {
"id": "C0014704",
"name": "ergometrine",
"pos": [
107,
118
]
} |
comparison between chromosomal and nuclear sap rna from chironomus tentans salivary gland cells by rna-dna hybridization . | NA | {
"id": "C0035700",
"name": "nuclear",
"pos": [
35,
42
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
99,
102
]
} |
thyrotropin releasing hormone ( trh ) mediated thyroid-stimulating hormone ( tsh ) release from human anterior pituitary tissue in vitro . | NA | {
"id": "C0040160",
"name": "thyroid-stimulating hormone",
"pos": [
47,
74
]
} | {
"id": "C0032016",
"name": "anterior pituitary",
"pos": [
102,
120
]
} |
intravenous infusions of phenylephrine , noradrenaline , adrenaline , and isoprenaline were given to healthy human volunteers after five to seven days on phenelzine , tranylcypromine , or imipramine , and cardiovascular responses were compared with those observed under control conditions . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
41,
54
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
57,
67
]
} |
with monoamine oxidase inhibitors there was a 2-2 ( 1/2 ) fold potentiation of the pressor effect of phenylephrine , but no clinically significant potentiation of cardiovascular effects of noradrenaline , adrenaline , or isoprenaline . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
189,
202
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
205,
215
]
} |
with imipramine there was potentiation of the pressor effects of phenylephrine ( 2-3 fold ) , noradrenaline ( 4-8 fold ) , and adrenaline ( 2-4 fold ) ; | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
94,
107
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
127,
137
]
} |
noradrenaline and adrenaline in amounts contained in local anaesthetics used in dentistry are not likely to be significantly potentiated in otherwise healthy patients receiving monoamine oxidase inhibitors . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
0,
13
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
18,
28
]
} |
it was , however , shown to be distinct from two other lymphocyte mediators , chemotactic factor for macrophages and lymphotoxin . | NA | {
"id": "C0024297",
"name": "lymphocyte mediators",
"pos": [
55,
75
]
} | {
"id": "C0024320",
"name": "lymphotoxin",
"pos": [
117,
128
]
} |
they were not found in monoclonal igm proteins that lacked anti-gamma-globulin activity although related antigens were detected at low concentrations in pooled immunoglobulin preparations as well as in heterogeneous anti-rh antibodies . | NA | {
"id": "C0017007",
"name": "gamma-globulin",
"pos": [
64,
78
]
} | {
"id": "C0021027",
"name": "immunoglobulin",
"pos": [
160,
174
]
} |
the separation of responses of the capsular and vascular smooth muscle was mimicked by close arterial infusions of either adrenaline or noradrenaline.5 . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
122,
132
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
136,
149
]
} |
the maximum responses of the splenic vascular smooth muscle to nerve stimulation , adrenaline and noradrenaline were not significantly different.6 . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
83,
93
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
98,
111
]
} |
iodoacetic acid ( 5 x 10 ( -4 ) m ) , glucose deprivation , dinitrophenol ( dnp , 5 x 10 ( -4 ) m ) and anoxia , singly , did not affect the accumulation of noradrenaline , but combined treatment with glucose deprivation and anoxia , or glucose deprivation and dinitrophenol , very markedly interfered with noradrenaline... | NA | {
"id": "C0045511",
"name": "dnp",
"pos": [
76,
79
]
} | {
"id": "C0012466",
"name": "dinitrophenol",
"pos": [
261,
274
]
} |
next , antigen-antibody complexes were split with salt or acid and separated into a low molecular weight ( or `` '' antigen '' '' ) fraction ( < 100,000 ) and a high molecular weight ( or `` '' antibody '' '' ) fraction ( > 100,000 ) . | NA | {
"id": "C0003313",
"name": "antigen-antibody complexes",
"pos": [
7,
33
]
} | {
"id": "C0003241",
"name": "`` '' antib",
"pos": [
188,
199
]
} |
the antiandrogenic action of 4-androsten-3-one-17 beta-carboxylic acid and its methyl ester on hamster flank organ . | NA | {
"id": "C0007066",
"name": "carboxylic acid",
"pos": [
55,
70
]
} | {
"id": "C0014898",
"name": "ester",
"pos": [
86,
91
]
} |
one pathway of blood coagulation , the extrinsic system , is initiated by a specific interaction between tissue factor , which is a membrane lipoprotein , and factor vii , one of the plasma coagulation factors . | NA | {
"id": "C0040048",
"name": "tissue factor",
"pos": [
105,
118
]
} | {
"id": "C0005789",
"name": "coagulation factors",
"pos": [
190,
209
]
} |
cultures of human diploid fibroblasts were labeled with radioactive proline and glycine , and the precursor of collagen ( procollagen ) in cells and medium was characterized by sodium dodecyl sulfate-polyacrylamide gel electrophoresis . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
26,
37
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
139,
144
]
} |
cultures of human diploid fibroblasts were labeled with radioactive proline and glycine , and the precursor of collagen ( procollagen ) in cells and medium was characterized by sodium dodecyl sulfate-polyacrylamide gel electrophoresis . | NA | {
"id": "C0009325",
"name": "collagen",
"pos": [
111,
119
]
} | {
"id": "C0033235",
"name": "procollagen",
"pos": [
122,
133
]
} |
one protein band in the 40s ribosomal subunit and six protein bands in the 60s subunit are phosphorylated , as demonstrated by na dodecyl sulfate-polyacrylamide gel electrophoresis and autoradiography . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
4,
11
]
} | {
"id": "C0599220",
"name": "protein",
"pos": [
54,
61
]
} |
this protein kinase activity phosphorylates one protein band in the 40s subunit different from that phosphorylated by the other two kinases and four bands in the 60s subunit , only one of which is coincident with the proteins phosphorylated by the histone-specific activities . | NA | {
"id": "C0599220",
"name": "protein",
"pos": [
5,
12
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
217,
225
]
} |
velocity sedimentation of the dna in sucrose gradients disclosed that markers that retained biological activity were present in dna particles that were of the order of 1 x 10 ( 6 ) daltons or larger , and indicated a close correlation between the size of the dna fragment and the amount of biological activity retained . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
30,
33
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
313,
314
]
} |
analysis of the interactions of the arylhydrazinopyrimidines and nucleic acid bases by nuclear magnetic resonance suggested that hydroxyphenylhydrazino-uracil and hydroxyphenylhydrazino-isocytosine pair in a novel manner with , respectively , cytosine and thymine . | NA | {
"id": "C0041917",
"name": "uracil",
"pos": [
152,
158
]
} | {
"id": "C0040087",
"name": "thymine",
"pos": [
256,
263
]
} |
an extract from a liver biopsy of a patient with classical phenylketonuria contains phenylalanine 4-hydroxylase ( ec 1.14.3.1 ) with a specific activity 0.27 % of the normal activity of the hydroxylase . | NA | {
"id": "C0031456",
"name": "phenylalanine 4-hydroxylase",
"pos": [
84,
111
]
} | {
"id": "C0020364",
"name": "hydroxylase",
"pos": [
190,
201
]
} |
this enzyme from a patient with phenylketonuria is a structurally altered form of phenylalanine 4-hydroxylase that probably results from a mutation in the gene coding for the hydroxylase . | NA | {
"id": "C0031456",
"name": "phenylalanine 4-hydroxylase",
"pos": [
82,
109
]
} | {
"id": "C0020364",
"name": "hydroxylase",
"pos": [
175,
186
]
} |
loss of methionine acceptor activity resulting from a base change in the anticodon of escherichia coli formylmethionine transfer ribonucleic acid . | NA | {
"id": "C0003284",
"name": "anticodon",
"pos": [
73,
82
]
} | {
"id": "C0035711",
"name": "transfer ribonucleic acid",
"pos": [
120,
145
]
} |
the endemic s. aureus strains of phage type 84/85 were uniformly resistant to eight other antibiotics including lincomycin and clindamycin . | NA | {
"id": "C0023726",
"name": "lincomycin",
"pos": [
112,
122
]
} | {
"id": "C0008947",
"name": "clindamycin",
"pos": [
127,
138
]
} |
results obtained with sera from nonvaccinated children and with immune sera from children vaccinated with three and four injections of diphtheria pertussis tetanus vaccine were in agreement with antitoxin levels considered necessary to denote immunity to diphtheria . | NA | {
"id": "C0020960",
"name": "immune sera",
"pos": [
64,
75
]
} | {
"id": "C0003445",
"name": "antitoxin",
"pos": [
195,
204
]
} |
sodium chloride and sodium bicarbonate of low concentration , near isotonic with blood plasma , stimulate abomasal emptying but the bicarbonate is most effective . | NA | {
"id": "C0074722",
"name": "sodium bicarbonate",
"pos": [
20,
38
]
} | {
"id": "C0005367",
"name": "bicarbonate",
"pos": [
132,
143
]
} |
hypotonic and isotonic solutions of sodium chloride and sodium bicarbonate increase abomasal emptying but bicarbonate is most effective.4 . | NA | {
"id": "C0074722",
"name": "sodium bicarbonate",
"pos": [
56,
74
]
} | {
"id": "C0005367",
"name": "bicarbonate",
"pos": [
106,
117
]
} |
effect of phenobarbital and skf 525a on the toxicity , elimination and metabolism of cyclophosphamide in newborn mice . | NA | {
"id": "C0221102",
"name": "elimination",
"pos": [
55,
66
]
} | {
"id": "C0025519",
"name": "metabolism",
"pos": [
71,
81
]
} |
pathologic findings were compatible with adenovirus type 7 pneumonia , and were characterized by a necrotizing bronchitis and bronchiolitis , patchy alveolar fibrinopurulent exudate and hyaline membrane formation . | NA | {
"id": "C0006277",
"name": "bronchitis",
"pos": [
111,
121
]
} | {
"id": "C0006271",
"name": "bronchiolitis",
"pos": [
126,
139
]
} |
these results indicate that uptake and/or integration of dna molecules bearing these genetic markers is enhanced at the time these markers replicate in the competent cell . | NA | {
"id": "C0017393",
"name": "genetic markers",
"pos": [
85,
100
]
} | {
"id": "C0005516",
"name": "markers",
"pos": [
131,
138
]
} |
it is tentatively concluded that the yeast amber suppressor does not contain a transfer rna altered in the anticodon . | NA | {
"id": "C0035711",
"name": "transfer rna",
"pos": [
79,
91
]
} | {
"id": "C0003284",
"name": "anticodon",
"pos": [
107,
116
]
} |
the effect of environmental temperature and fluid therapy on mortality and metabolism of mice after burn and tourniquet trauma . | NA | {
"id": "C0006434",
"name": "burn",
"pos": [
100,
104
]
} | {
"id": "C0043251",
"name": "trauma",
"pos": [
120,
126
]
} |
malignant lymphoma including hodgkin 's disease occurring in the vicinity of a large medical center ( olmsted county , minn. , 1945 through 1969 ) . | NA | {
"id": "C0024299",
"name": "malignant lymphoma",
"pos": [
0,
18
]
} | {
"id": "C0019829",
"name": "hodgkin 's disease",
"pos": [
29,
47
]
} |
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