text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
a mutant of escherichia coli with reduced levels of biosynthetic arginine decarboxylase was isolated which required putrescine or spermidine for optimal growth . | NA | {
"id": "C0034170",
"name": "putrescine",
"pos": [
116,
126
]
} | {
"id": "C0037871",
"name": "optimal",
"pos": [
145,
152
]
} |
specificity studies supported the concept that the requirement was for spermidine or closely related polyamines , or for diamines which could be converted enzymatically to these compounds . | NA | {
"id": "C0032433",
"name": "polyamines",
"pos": [
101,
111
]
} | {
"id": "C0011957",
"name": "diamines",
"pos": [
121,
129
]
} |
three of five amino acids tested . l-glutamic acid , l-aspartic acid , and l-alanine , were concentrated against a gradient in the cells . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
14,
25
]
} | {
"id": "C0001898",
"name": "l-alanine",
"pos": [
75,
84
]
} |
when a narrow portion of this peak about k ( d ) 0.15 , containing most of the mif activity , was subjected to analytical isoelectric focusing , all of the label was associated with proteins of lower net charge than albumin . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
182,
190
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
216,
223
]
} |
estetrol in molar pregnancies quantitated by a rapid gas chromatographic method in conjunction with estrone , estradiol-17 , estriol , and pregnanediol . | NA | {
"id": "C0014899",
"name": "estetrol",
"pos": [
0,
8
]
} | {
"id": "C0014927",
"name": "estriol",
"pos": [
125,
132
]
} |
of 21 l-amino acids tested ( at 1.2 x 10 ( -4 ) m ) , only histidine and the aromatic amino acids ( phenylalanine , tryptophan , and tyrosine ) protect salmonella typhimurium strains from inhibition of growth and immediately reverse the growth inhibition by 5 x 10 ( -4 ) m 2-thiazole-dl-alanine . | NA | {
"id": "C0301713",
"name": "aromatic",
"pos": [
77,
85
]
} | {
"id": "C0031453",
"name": "phenylalanine",
"pos": [
100,
113
]
} |
of 21 l-amino acids tested ( at 1.2 x 10 ( -4 ) m ) , only histidine and the aromatic amino acids ( phenylalanine , tryptophan , and tyrosine ) protect salmonella typhimurium strains from inhibition of growth and immediately reverse the growth inhibition by 5 x 10 ( -4 ) m 2-thiazole-dl-alanine . | NA | {
"id": "C0301713",
"name": "aromatic",
"pos": [
77,
85
]
} | {
"id": "C0041249",
"name": "tryptophan",
"pos": [
116,
126
]
} |
of 21 l-amino acids tested ( at 1.2 x 10 ( -4 ) m ) , only histidine and the aromatic amino acids ( phenylalanine , tryptophan , and tyrosine ) protect salmonella typhimurium strains from inhibition of growth and immediately reverse the growth inhibition by 5 x 10 ( -4 ) m 2-thiazole-dl-alanine . | NA | {
"id": "C0301713",
"name": "aromatic",
"pos": [
77,
85
]
} | {
"id": "C0041485",
"name": "tyrosine",
"pos": [
133,
141
]
} |
the protein lacks hemagglutinating activity but binds completely strain-specific , hemagglutination-inhibiting antibodies and induces neutralizing antibodies in experimental animals . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
111,
121
]
} | {
"id": "C0475463",
"name": "neutralizing antibodies",
"pos": [
134,
157
]
} |
activities and isoenzyme patterns of some enzymes of glucose metabolism in human primary malignant hepatoma . | NA | {
"id": "C0022173",
"name": "isoenzyme",
"pos": [
15,
24
]
} | {
"id": "C0014442",
"name": "enzymes",
"pos": [
42,
49
]
} |
factors influencing the rate of formation of nitrosomorpholine from morpholine and nitrite : acceleration by thiocyanate and other anions . | NA | {
"id": "C0028137",
"name": "nitrite",
"pos": [
83,
90
]
} | {
"id": "C0003075",
"name": "anions",
"pos": [
131,
137
]
} |
termination of tolerance to human gamma globulin in mice by antigen and bacterial lipopolysaccharide ( endotoxin ) . | NA | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
82,
100
]
} | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
103,
112
]
} |
bacterial lipopolysaccharides ( endotoxin ) allowed the circumvention of the thymus-derived ( t ) cell helper function otherwise required for the antibody response in mice to human gamma globulin ( hgg ) . | NA | {
"id": "C0023810",
"name": "lipopolysaccharides",
"pos": [
10,
29
]
} | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
32,
41
]
} |
the role of h 2 o 2 generation in perfused rat liver and the reaction of catalase compound i and hydrogen donors . | NA | {
"id": "C0011744",
"name": "h 2",
"pos": [
12,
15
]
} | {
"id": "C0020275",
"name": "hydrogen",
"pos": [
97,
105
]
} |
an enzyme is present in extracts of rabbit alveolar macrophage which can catalyze the reaction of creatine phosphate with adenosine diphosphate to form adenosine triphosphate and creatine . | NA | {
"id": "C0031634",
"name": "creatine phosphate",
"pos": [
98,
116
]
} | {
"id": "C0010286",
"name": "creatine",
"pos": [
179,
187
]
} |
[ hypertension : 3 h-catecholamine metabolism in the adrenal glands and brain and tissue metabolism of 3 3 h-dopa during reserpine , alpha-methyl dopa and st-155 administration in spontaneously hypertensive rats ] . | NA | {
"id": "C0013023",
"name": "dopa",
"pos": [
109,
113
]
} | {
"id": "C0025741",
"name": "alpha-methyl dopa",
"pos": [
133,
150
]
} |
further studies on glycosidases from the liver of turbo cornutus with special reference to -galactosidase , -l-arabinosidase , and -d-fucosidase activities . | NA | {
"id": "C0017976",
"name": "glycosidases",
"pos": [
19,
31
]
} | {
"id": "C0016955",
"name": "galactosidase",
"pos": [
92,
105
]
} |
inheritance of red cell carbonic anhydrase levels in different carbonic anhydrase i genotypes of the pig-tailed macaque , macaca nemestrina . | NA | {
"id": "C0007028",
"name": "carbonic anhydrase",
"pos": [
24,
42
]
} | {
"id": "C0007033",
"name": "carbonic",
"pos": [
63,
71
]
} |
hence , most of the divalent cation appears to be bound to membrane lipids , most probably to phospholipids . | NA | {
"id": "C0025249",
"name": "membrane lipids",
"pos": [
59,
74
]
} | {
"id": "C0031676",
"name": "phospholipids",
"pos": [
94,
107
]
} |
in this study , oligosaccharides containing more than one repeating unit were isolated from a lipopolysaccharide of a group b salmonella , and the anomeric configuration of the rhamnosyl residues was determined by the comparison of optical rotatory powers of these oligosaccharides with that of the repeating unit trisac... | NA | {
"id": "C0028959",
"name": "oligosaccharides",
"pos": [
16,
32
]
} | {
"id": "C0041102",
"name": "trisaccharide",
"pos": [
314,
327
]
} |
in the presence of 8 mug of act d/ml , germinating myxospores synthesized transfer rna , 16s rna , and 23s rna . | NA | {
"id": "C0035711",
"name": "transfer rna",
"pos": [
74,
86
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
107,
110
]
} |
the compounds which rendered p-503 colorless , such as cyanide , azide , hydrazine , thiocyanate , hydroxylamine , dithionite , sulfite , and methylcyanide , also rendered tetrahydroporphyrin colorless . | NA | {
"id": "C0012787",
"name": "dithionite",
"pos": [
115,
125
]
} | {
"id": "C0038750",
"name": "sulfite",
"pos": [
128,
135
]
} |
indeed , the only enzyme test that correlated well with electrocardiographic and necropsy findings was the mb isoenzyme . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
18,
24
]
} | {
"id": "C0022173",
"name": "isoenzyme",
"pos": [
110,
119
]
} |
mutant strains of pseudomonas putida strain u have been obtained which are deficient in enzymes of the degradative pathways of phenol and cresols . | NA | {
"id": "C0031428",
"name": "phenol",
"pos": [
127,
133
]
} | {
"id": "C0010305",
"name": "cresols",
"pos": [
138,
145
]
} |
thus , the low mobilities of intracellular ions appeared to be interpretable in terms of the physicochemical behavior of electrolytes in concentrated mixtures of small ions and cell polymers . | NA | {
"id": "C0013832",
"name": "electrolytes",
"pos": [
121,
133
]
} | {
"id": "C0022023",
"name": "ions",
"pos": [
168,
172
]
} |
omission of iron from the growth medium gave inactive preparations of anthranilate hydroxylase which could be reactivated by incubating the enzyme preparations with ferric citrate . | NA | {
"id": "C0302583",
"name": "iron",
"pos": [
12,
16
]
} | {
"id": "C0060231",
"name": "ferric citrate",
"pos": [
165,
179
]
} |
in cultures simultaneously given 160 mum uracil ( u ) along with the fu , dna synthesis still stopped , but cell division continued for one generation at the control rate and at a much slower rate beyond that ; | NA | {
"id": "C0041917",
"name": "uracil",
"pos": [
41,
47
]
} | {
"id": "C0016360",
"name": "fu",
"pos": [
69,
71
]
} |
leprosy bacilli harvested from freshly biopsied tissue from cases of lepromatous , borderline and histoid leprosy were , in conjunction with mycobacterium lepraemurium and representative mycobacteria , examined cytochemically with and without their pyridine-extractable acid-fastness . | NA | {
"id": "C1562585",
"name": "lepromatous",
"pos": [
69,
80
]
} | {
"id": "C0023343",
"name": "leprosy",
"pos": [
106,
113
]
} |
addition of glycolipids obtained from salmonella minnesota r mutants to normal , spontaneously transformed , and sv40-transformed rat embryo fibroblasts in culture results in an inhibition of growth of transformed cells but not of normal cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
141,
152
]
} | {
"id": "C0007634",
"name": "normal cells",
"pos": [
231,
243
]
} |
the spinal cord blood flow has been measured in anaesthetized dogs using an inert radioactive gas ( ( 133 ) xenon ) clearance technique . | NA | {
"id": "C0017112",
"name": "inert",
"pos": [
76,
81
]
} | {
"id": "C0043339",
"name": "xenon",
"pos": [
108,
113
]
} |
the differences between the pattern of hypertonus in athetosis , parkinson 's disease , spasticity , and activated normal subjects are presented in discussion . | NA | {
"id": "C0026826",
"name": "hypertonus",
"pos": [
39,
49
]
} | {
"id": "C0026838",
"name": "spasticity",
"pos": [
88,
98
]
} |
the rna-ribosome complexes were characterized by ( i ) their sensitivity to the action of ribonuclease or ethylenediaminetetraacetic acid , ( ii ) their density in cesium chloride gradients , and ( iii ) presence of host ribosomes and viral rnas . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
4,
7
]
} | {
"id": "C0035736",
"name": "viral rnas",
"pos": [
235,
245
]
} |
[ allergic rhinosinusitis and allergy of the lower respiratory passages . value of the acetylcholine bronchial provocation tests in detection of latent asthma ] . | NA | {
"id": "C2607914",
"name": "allergic rhinosinusitis",
"pos": [
2,
25
]
} | {
"id": "C0035228",
"name": "allergy",
"pos": [
30,
37
]
} |
plasma-level studies of chlorpromazine following the administration of chlorpromazine hydrochloride and chlorpromazine embonate in chronic schizophrenics . | NA | {
"id": "C0008286",
"name": "chlorpromazine",
"pos": [
24,
38
]
} | {
"id": "C0355077",
"name": "chlorpromazine hydrochloride",
"pos": [
71,
99
]
} |
the timing of these reactions was compatible with the concept that gluten acts as an antigen and combines with antibody in the form of immune complexes in the connective tissue close to the epithelium and to small blood vessels . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
111,
119
]
} | {
"id": "C0003313",
"name": "immune",
"pos": [
135,
141
]
} |
a perfusion technique has been used to quantitate the effect of the amino acids glycine and alanine and the dipeptides glycyl-glycine and glycyl-l-alanine on sodium and water absorption from the human jejunum . | NA | {
"id": "C0012512",
"name": "dipeptides",
"pos": [
108,
118
]
} | {
"id": "C0017984",
"name": "glycyl-glycine",
"pos": [
119,
133
]
} |
in the case of glycine and alanine , sodium and water absorption increased linearly with increasing concentration of the amino acid and saturation was not demonstrated over the range of concentrations studied . | NA | {
"id": "C0017890",
"name": "glycine",
"pos": [
15,
22
]
} | {
"id": "C0002520",
"name": "amino acid",
"pos": [
121,
131
]
} |
in the case of glycine and alanine , sodium and water absorption increased linearly with increasing concentration of the amino acid and saturation was not demonstrated over the range of concentrations studied . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
27,
34
]
} | {
"id": "C0002520",
"name": "amino acid",
"pos": [
121,
131
]
} |
molar ratios for net absorption of free amino acid and sodium were approximately 1:1 for all but the highest concentration of alanine . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
40,
50
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
126,
133
]
} |
fractionation on antigen-coated sepharose beads showed that b cells could be subdivided in two major groups : those reacting against the haptenic group ( dnp ) and those reactive against the new antigenic determinants ( nads ) introduced into the protein carrier by the hapten coupling . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
17,
24
]
} | {
"id": "C0003316",
"name": "antigenic determinants",
"pos": [
195,
217
]
} |
fractionation on antigen-coated sepharose beads showed that b cells could be subdivided in two major groups : those reacting against the haptenic group ( dnp ) and those reactive against the new antigenic determinants ( nads ) introduced into the protein carrier by the hapten coupling . | NA | {
"id": "C0003316",
"name": "antigenic determinants",
"pos": [
195,
217
]
} | {
"id": "C0018593",
"name": "hapten",
"pos": [
270,
276
]
} |
it was shown previously that humoral antibodies formed against hapten-mouse serum albumin conjugates also were directed against these two groups of antigenic determinants and that the immune response to the nads does not follow the genetic rules of high or low response against the hapten used . | NA | {
"id": "C0003316",
"name": "antigenic determinants",
"pos": [
148,
170
]
} | {
"id": "C0018593",
"name": "hapten",
"pos": [
282,
288
]
} |
all together these findings support the distinct nature of the nads over the haptenic groups , as recognized both at the humoral and cellular level . | NA | {
"id": "C0003316",
"name": "nads",
"pos": [
63,
67
]
} | {
"id": "C0018593",
"name": "haptenic",
"pos": [
77,
85
]
} |
insertion of the lipid a portion of lipopolysaccharides into the lipid bilayer of the plasma membranes of bone marrow-derived lymphocytes is discussed as the initial mitogenic action . | NA | {
"id": "C0023767",
"name": "lipid a",
"pos": [
17,
24
]
} | {
"id": "C0023810",
"name": "lipopolysaccharides",
"pos": [
36,
55
]
} |
previous work has shown that the immediate precursor of b lymphocytes ( pb cell ) has many properties that distinguish it from both b lymphoctes and hemopoietic stem cells . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
75,
79
]
} | {
"id": "C0018956",
"name": "hemopoietic",
"pos": [
149,
160
]
} |
the relationship between net tubular reabsorption of sodium and renal microsomal sodium- and potassium-activated adenosine triphosphatase ( na-k-atpase ) was evaluated in hypothyroid and hyperthyroid rats and in age-matched euthyroid controls . | NA | {
"id": "C0001473",
"name": "adenosine triphosphatase",
"pos": [
113,
137
]
} | {
"id": "C0001479",
"name": "na-k-atpase",
"pos": [
140,
151
]
} |
this decrement was present in both cortex and outer medulla , and was limited to na-k-atpase since other representative enzymes not involved in sodium transport ( magnesium-dependent adenosine triphosphatase [ mg-atpase ] , glucose-6-phosphatase , 5'-nucleotidase ) remained unchanged or increased in the hypothyroid ani... | NA | {
"id": "C0001479",
"name": "na-k-atpase",
"pos": [
81,
92
]
} | {
"id": "C0001473",
"name": "atpase",
"pos": [
213,
219
]
} |
this decrement was present in both cortex and outer medulla , and was limited to na-k-atpase since other representative enzymes not involved in sodium transport ( magnesium-dependent adenosine triphosphatase [ mg-atpase ] , glucose-6-phosphatase , 5'-nucleotidase ) remained unchanged or increased in the hypothyroid ani... | NA | {
"id": "C0001477",
"name": "magnesium",
"pos": [
163,
172
]
} | {
"id": "C0001473",
"name": "atpase",
"pos": [
213,
219
]
} |
resumption of normal dietary purine intake or the addition of adenine ( 10 mg/kg per day ) to a purinefree diet resulted in a fall in hgprt activity . | NA | {
"id": "C0034140",
"name": "purine",
"pos": [
29,
35
]
} | {
"id": "C0001407",
"name": "adenine",
"pos": [
62,
69
]
} |
epinephrine and norepinephrine were separated by acid elution through a sephadex g-10 column with high recovery ( better than 90 % ) , excellent reproducibility , and little overlap ( less than 10 % ) . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
0,
11
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
16,
30
]
} |
in the reported haemagglutination test on human and rabbit antisera the findings suggested that only igm ( 19s ) antibodies took part in the reaction . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
59,
67
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
113,
123
]
} |
homology between epstein-barr virus dna and viral dna from burkitt 's lymphoma and nasopharyngeal carcinoma determined by dna-dna reassociation kinetics . | NA | {
"id": "C0012939",
"name": "viral dna",
"pos": [
44,
53
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
126,
129
]
} |
they were classified as epidermoid carcinoma , mucus-secreting cell adenocarcinoma , and alveolar cell adenocarcinoma , the latter made up of granular pneumocytes . | NA | {
"id": "C0001418",
"name": "adenocarcinoma",
"pos": [
68,
82
]
} | {
"id": "C0007120",
"name": "alveolar",
"pos": [
89,
97
]
} |
epimerization of carbon 2 ' of adenosine during the biosynthesis of 9- -d -- arabinofuranosyladenine by streptomyces antibioticus . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
31,
40
]
} | {
"id": "C0042646",
"name": "arabinofuranosyladenine",
"pos": [
77,
100
]
} |
multiplication-stimulating activity for chicken embryo fibroblasts from rat liver cell conditioned medium : a family of small polypeptides . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
55,
66
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
82,
86
]
} |
cryoprecipitates and immune complexes : decrease in antibody bound 131 i-labeled bsa antigen after cryoprecipitation in rabbit serum . | NA | {
"id": "C0003313",
"name": "immune complexes",
"pos": [
21,
37
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
52,
60
]
} |
the in vitro demonstration of the efficacy of trimethoprim as an antibacterial agent in a comparative bacteriological study of the effects of trimethoprim , sulfamethoxazole and the combination trimethoprim-sulfamethoxazole . | NA | {
"id": "C0038689",
"name": "sulfamethoxazole",
"pos": [
157,
173
]
} | {
"id": "C0041044",
"name": "trimethoprim-sulfamethoxazole",
"pos": [
194,
223
]
} |
a comparison between pivampicillin , ampicillin and penicillin g in the treatment of acute uncomplicated gonorrhoea . | NA | {
"id": "C0032032",
"name": "pivampicillin",
"pos": [
21,
34
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
37,
47
]
} |
a comparison between pivampicillin , ampicillin and penicillin g in the treatment of acute uncomplicated gonorrhoea . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
24,
34
]
} | {
"id": "C0030827",
"name": "penicillin g",
"pos": [
52,
64
]
} |
differences in effects in gamma and alpha spasticity induced by the gaba derivative baclofen ( lioresal ) . | NA | {
"id": "C0016904",
"name": "gaba",
"pos": [
68,
72
]
} | {
"id": "C0004609",
"name": "baclofen",
"pos": [
84,
92
]
} |
[ changes in the elimination of histamine , noradrenaline , adrenaline and vanilmandelic acid during high-mountain climatic therapy at strbske pleso ] . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
44,
57
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
60,
70
]
} |
growth inhibition of murine tumor cells , in vitro , by puromycin , ( 6 n ) o 2 '-dibutyryl 3',5'-adenosine monophosphate , or adenosine : evidence of commitment for cell division . | NA | {
"id": "C0034145",
"name": "puromycin",
"pos": [
56,
65
]
} | {
"id": "C0001443",
"name": "adenosine",
"pos": [
127,
136
]
} |
the selectivity of the gel water for potassium relative to sodium increased to a maximum when the gel surface was partially ionized so that distribution of cations was not linked to distribution of anions , and then decreased as the surface changed from a hydrogen bonding to an ionic surface . | NA | {
"id": "C0007447",
"name": "cations",
"pos": [
156,
163
]
} | {
"id": "C0022023",
"name": "ionic",
"pos": [
279,
284
]
} |
the selectivity of the gel water for potassium relative to sodium increased to a maximum when the gel surface was partially ionized so that distribution of cations was not linked to distribution of anions , and then decreased as the surface changed from a hydrogen bonding to an ionic surface . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
198,
204
]
} | {
"id": "C0022023",
"name": "ionic",
"pos": [
279,
284
]
} |
there is a close relationship between the site and extent of fibrin , as detected by immunofluorescence , and the maximal urinary fdp excretion . | NA | {
"id": "C0015982",
"name": "fibrin",
"pos": [
61,
67
]
} | {
"id": "C0163275",
"name": "fdp",
"pos": [
130,
133
]
} |
the effect of noradrenaline and adrenaline on hepatosplanchnic hemodynamics , functional capacity of the liver and hepatic metabolism . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
14,
27
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
32,
42
]
} |
[ mineral water therapy of urolithiasis : its success depending on the degree of mineralization and gas content of the waters ] . | NA | {
"id": "C0026157",
"name": "mineral water",
"pos": [
2,
15
]
} | {
"id": "C0043047",
"name": "waters",
"pos": [
119,
125
]
} |
cyclic amp and intestinal glycoprotein synthesis : the effect of -adrenergic agents , theophylline , and dibutyryl cyclic amp . | NA | {
"id": "C0001455",
"name": "cyclic amp",
"pos": [
0,
10
]
} | {
"id": "C0012054",
"name": "dibutyryl cyclic amp",
"pos": [
105,
125
]
} |
clinical and pharmacological evaluation of cephapirin sodium ( bl-p-1322 ) in infants and children ( cephapirin in pediatric patients ) . | NA | {
"id": "C0085905",
"name": "cephapirin sodium",
"pos": [
43,
60
]
} | {
"id": "C0007737",
"name": "cephapirin",
"pos": [
101,
111
]
} |
the anemia-induced reversible switch from hemoglobin a to hemoglobin c in caprine ruminants : immunochemical evidence that both hemoglobins are found in the same cell . | NA | {
"id": "C0019016",
"name": "hemoglobin a",
"pos": [
42,
54
]
} | {
"id": "C0019046",
"name": "hemoglobins",
"pos": [
128,
139
]
} |
in 15 immune sera with titers of between 0.03 and 25 units/ml , the avidity was similar to that of u.s. standard antitoxin . | NA | {
"id": "C0020960",
"name": "immune sera",
"pos": [
6,
17
]
} | {
"id": "C0003445",
"name": "antitoxin",
"pos": [
113,
122
]
} |
immunodiffusion studies revealed that antigens i and ii share at least one antigenic determinant and that antigen iii is immunologically distinct from either antigen i or ii . | NA | {
"id": "C0003316",
"name": "antigenic determinant",
"pos": [
75,
96
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
158,
165
]
} |
the growth of one of the mutants we studied ( strain s9l100 ) is stimulated by the presence of ethanol , methanol , or dimethyl sulfoxide . | NA | {
"id": "C0001962",
"name": "ethanol",
"pos": [
95,
102
]
} | {
"id": "C0001963",
"name": "methanol",
"pos": [
105,
113
]
} |
the profiles of total lipids and of the molecular species of individual lipid classes were compared among corresponding lipoproteins of plasma and yolk of the laying hen . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
22,
27
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
120,
132
]
} |
the ( 3 ) h content was greater in large proteins that remained in the stacking gel ( group i , predominantly beta-apoprotein ) than in proteins with apparent molecular weights near 50,000 ( group ii ) or in the smaller peptides ( molecular weights near 10,000 , group iii ) . | NA | {
"id": "C0003601",
"name": "apoprotein",
"pos": [
115,
125
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
136,
144
]
} |
since these peptides were always present in vldl from mesenteric lymph collected in vivo , the results suggest that nascent vldl of gut origin acquires group iii peptides from other lipoproteins that penetrate lymph from plasma . | NA | {
"id": "C0023825",
"name": "vldl",
"pos": [
44,
48
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
182,
194
]
} |
the incidence of lobulated fibres in the facioscapulo-humeral type of muscular dystrophy and the limb-girdle syndrome . | NA | {
"id": "C0026850",
"name": "muscular",
"pos": [
70,
78
]
} | {
"id": "C0686353",
"name": "limb-girdle syndrome",
"pos": [
97,
117
]
} |
[ partial growth hormone deficiency : endogenous growth hormone content and effect of exogenously administered human growth hormone ] . | NA | {
"id": "C0037663",
"name": "growth hormone",
"pos": [
10,
24
]
} | {
"id": "C0169964",
"name": "human growth hormone",
"pos": [
111,
131
]
} |
comparative effect of chloramphenicol and thiamphenicol on dna and mitochondrial protein synthesis in mammalian cells . | NA | {
"id": "C0008168",
"name": "chloramphenicol",
"pos": [
22,
37
]
} | {
"id": "C0039854",
"name": "thiamphenicol",
"pos": [
42,
55
]
} |
immobilized enzymes : a prototype apparatus for oxidase enzymes in chemical analysis utilizing covalently bound glucose oxidase . | NA | {
"id": "C0014444",
"name": "immobilized enzymes",
"pos": [
0,
19
]
} | {
"id": "C0014442",
"name": "enzymes",
"pos": [
56,
63
]
} |
proliferation of the connective tissue in hypertrophying muscle was evident in light micrographs , and electron micrographs identified the proliferating cells as enlarged fibroblasts and macrophages ; | NA | {
"id": "C0007634",
"name": "the",
"pos": [
17,
20
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
171,
182
]
} |
[ isolation of immunoelectrophoretically pure -lipoproteins using hydroxyapatite chromatography and study of the relation to lipids ] . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
47,
59
]
} | {
"id": "C0023779",
"name": "lipids",
"pos": [
125,
131
]
} |
the product was not contaminated with any detectable amount of other amino acids , except for glycine which was present at a concentration of less than 1 percent . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
69,
80
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
94,
101
]
} |
it has been postulated that 3- ( 3-oxo-7alpha-methylthio-4-androsten-17alpha-yl ) propionic acid gamma-lactone ( i ) is a key intermediate in the metabolism of the anti-aldosterone agent , spironolactone ( 3- [ 3-oxo-7alpha-acetylthio-17beta-hydroxy-4-androsten-17alpha-yl ] propionic acid gamma-lactone ) . | NA | {
"id": "C0037982",
"name": "spironolactone",
"pos": [
189,
203
]
} | {
"id": "C0022947",
"name": "lactone",
"pos": [
296,
303
]
} |
the temporal relationship of thyroiditis and retroperitoneal fibrosis suggests an extension of fibrosis from the thyroid , but one can not be sure which condition occurred first . | NA | {
"id": "C0035357",
"name": "retroperitoneal fibrosis",
"pos": [
45,
69
]
} | {
"id": "C0016059",
"name": "fibrosis",
"pos": [
95,
103
]
} |
it is postulated that the sickling of the erythrocytes in the periureteral vessels resulted in thrombosis , ischemia , reactive scarring and progressive fibrosis indistinguishable from the known histological picture of retroperitoneal fibrosis . | NA | {
"id": "C0016059",
"name": "fibrosis",
"pos": [
153,
161
]
} | {
"id": "C0035357",
"name": "retroperitoneal fibrosis",
"pos": [
219,
243
]
} |
the effects of methallibure ( i.c.i . 33,828 ) and thiourea on gametogenesis in the firetail gudgeon , hypseleotris galii . | NA | {
"id": "C0025609",
"name": "methallibure",
"pos": [
15,
27
]
} | {
"id": "C0039958",
"name": "thiourea",
"pos": [
51,
59
]
} |
effect of cycloleucine and parachlorophenylalanine on phenylalanine reabsorption in the renal tubule of the rhesus monkey . | NA | {
"id": "C0030135",
"name": "parachlorophenylalanine",
"pos": [
27,
50
]
} | {
"id": "C0031453",
"name": "phenylalanine",
"pos": [
54,
67
]
} |
different thyroid function tests permitted a final classification of 204 consecutive patients with suspected thyroid disorders into three populations ( thyrotoxic , euthyroid , and hypothyroid ) . | NA | {
"id": "C0040128",
"name": "thyroid disorders",
"pos": [
109,
126
]
} | {
"id": "C0020676",
"name": "hypothyroid",
"pos": [
181,
192
]
} |
hitherto existing statements on the lymphogenic metastases of this tumor have been made by means of method whose statements have been limited by the non-presentability of the pelvic lymph nodes , inflammatory-degeneratively changed lymph nodes , and micrometastases . | NA | {
"id": "C0027627",
"name": "metastases",
"pos": [
48,
58
]
} | {
"id": "C1513276",
"name": "micrometastases",
"pos": [
250,
265
]
} |
attention is drawn to the practical reasons for distinguishing cpdd arthropathy from other arthropathies , particularly osteoarthritis ; | NA | {
"id": "C0152087",
"name": "cpdd",
"pos": [
63,
67
]
} | {
"id": "C0022408",
"name": "arthropathies",
"pos": [
91,
104
]
} |
these data support the concept of candida as an important participant in polymicrobial infection and recommend therapy with amphotericin b for patients with intraperitoneal infection experiencing fungemia . | NA | {
"id": "C0275524",
"name": "polymicrobial infection",
"pos": [
73,
96
]
} | {
"id": "C0009450",
"name": "infection",
"pos": [
173,
182
]
} |
the case was clarified after dimethylnitrosamine was demonstrated in food intended for the patient and after it was established that small amounts of nitrosamine could have been repeatedly ingested by the patient over a period of years . | NA | {
"id": "C0012431",
"name": "dimethylnitrosamine",
"pos": [
29,
48
]
} | {
"id": "C0028197",
"name": "nitrosamine",
"pos": [
150,
161
]
} |
a decrease in intracellular gsh levels was observed concomitant with an increased rate of accumulation of oxidized glutathione in the incubation medium . | NA | {
"id": "C0017817",
"name": "gsh",
"pos": [
28,
31
]
} | {
"id": "C0061516",
"name": "oxidized glutathione",
"pos": [
106,
126
]
} |
pretreatment of hepatocytes with an inhibitor of gssg-reductase ( 1,3-bis ( 2-chloroethyl ) -1-nitrosourea ) , prior to the addition of 50 microm selenite , resulted in substantially lower gsh-levels . | NA | {
"id": "C0061516",
"name": "gssg",
"pos": [
49,
53
]
} | {
"id": "C0017817",
"name": "gsh",
"pos": [
189,
192
]
} |
when compared on the basis of infectivity for fibroblasts and lymphoid cell killing capacity , pools of cmv with high infectivity had relatively less cell-killing capacity than low titered preparations . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
46,
57
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
150,
154
]
} |
the results indicated that charcoal hemoperfusion did not stimulate a hyperplastic response in the liver of the normal rat following perfusion , and did not produce marked changes in body weight , liver weight , and function . | NA | {
"id": "C0005911",
"name": "changes in",
"pos": [
172,
182
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
203,
209
]
} |
this abnormal dna may arise from a deficiency of an isozyme of one of the dna repair enzymes . | NA | {
"id": "C0022173",
"name": "isozyme",
"pos": [
52,
59
]
} | {
"id": "C0014442",
"name": "enzymes",
"pos": [
85,
92
]
} |
an 18-year-old man suffering from a hereditary hyperkalemic periodic paralysis showed , in addition , a hypermagnesemic periodic paralysis with a 2.5-fold increase in serum magnesium level . | NA | {
"id": "C0238357",
"name": "hyperkalemic periodic paralysis",
"pos": [
47,
78
]
} | {
"id": "C0030443",
"name": "periodic paralysis",
"pos": [
120,
138
]
} |
buccal epithelial , gingival fibroblast and white blood cells bound the ha-active fragments , as observed by : ( 1 ) decrease in the ha activity of the sonicated preparation after absorption , ( 2 ) increase in ha activity of the cells used for absorption , ( 3 ) presence of microbial fragments on the cells after absor... | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
29,
39
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
303,
308
]
} |
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