text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
it is concluded that the identical pathology at a cellular level in two different species may indicate a pathologic disorder in a process fundamental to the normal development of this type of hair cell . | NA | {
"id": "C0030660",
"name": "pathologic",
"pos": [
105,
115
]
} | {
"id": "C0012634",
"name": "disorder",
"pos": [
116,
124
]
} |
we noted granules of two sizes : those smaller than 20 nm contained heparan sulphate , and those from 20 to 50 nm in size contained chondroitin or dermatan sulphate . | NA | {
"id": "C0008454",
"name": "chondroitin",
"pos": [
132,
143
]
} | {
"id": "C0011602",
"name": "dermatan sulphate",
"pos": [
147,
164
]
} |
to define the roles , in vivo , of hepatic triglyceride lipase and lipoprotein lipase in the catabolism of triglyceride-rich lipoproteins , we investigated the relationship between the activities of the above enzymes in postheparin plasma and the fractional removal rates of very low density lipoproteins ( vldl ) and vl... | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
125,
137
]
} | {
"id": "C0023825",
"name": "very low density lipoproteins",
"pos": [
275,
304
]
} |
to define the roles , in vivo , of hepatic triglyceride lipase and lipoprotein lipase in the catabolism of triglyceride-rich lipoproteins , we investigated the relationship between the activities of the above enzymes in postheparin plasma and the fractional removal rates of very low density lipoproteins ( vldl ) and vl... | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
125,
137
]
} | {
"id": "C0065063",
"name": "vldl remnant",
"pos": [
318,
330
]
} |
in 22 patients , the fractional removal rates of vldl and vldl-remnant particles were determined from analyses of the disappearance of radioiodinated sf 60-400 and sf 12-60 lipoprotein b apoprotein . | NA | {
"id": "C0023825",
"name": "vldl",
"pos": [
49,
53
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
173,
184
]
} |
in 22 patients , the fractional removal rates of vldl and vldl-remnant particles were determined from analyses of the disappearance of radioiodinated sf 60-400 and sf 12-60 lipoprotein b apoprotein . | NA | {
"id": "C0065063",
"name": "vldl-remnant",
"pos": [
58,
70
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
173,
184
]
} |
whey albumin , beta-globulin and gamma-globulin fractions had similar electrophoretic mobility to that of the equivalent serum protein fractions , but the proteins in the alpha-globulin and pre-albumin regions differed markedly . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
155,
163
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
194,
201
]
} |
the inhibition of glucose-stimulated insulin release by adenosine and n ( 6 ) -phenylisopropyladenosine was abolished by 3-isobutyl-1-methylxanthine ( 0.1 mm ) , whereas 2-deoxyadenosine inhibited insulin release even in the presence of 3-isobutyl-1-methylxanthine . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
56,
65
]
} | {
"id": "C0031484",
"name": "phenylisopropyladenosine",
"pos": [
79,
103
]
} |
however , adenosine , 2-deoxyadenosine and n ( 6 ) -phenylisopropyladenosine produced marked inhibition of the glucose-stimulated increases seen in islet cyclic amp accumulation . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
10,
19
]
} | {
"id": "C0031484",
"name": "phenylisopropyladenosine",
"pos": [
52,
76
]
} |
similar to its effects on insulin release , 3-isobutyl-1-methylxanthine ( 0.1 mm ) antagonized the inhibitory effects of cyclic amp accumulation produced by adenosine and n ( 6 ) -phenylisopropyladenosine , but had no effect on the inhibition of cyclic amp accumulation seen with 2-deoxyadenosine . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
157,
166
]
} | {
"id": "C0031484",
"name": "phenylisopropyladenosine",
"pos": [
180,
204
]
} |
these results show that adenosine and its specifically modified analogues , 2-deoxyadenosine and n ( 6 ) -phenylisopropyladenosine , are strong inhibitors of insulin release from rat islets , a function that appears to be the consequence of their ability to inhibit the accumulation of cyclic amp . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
24,
33
]
} | {
"id": "C0031484",
"name": "phenylisopropyladenosine",
"pos": [
106,
130
]
} |
photosynthetic electron transport from water to lipophilic photosystem ii acceptors was stimulated 3 -- 5-fold by high concentrations ( greater than or equal to 1 m ) of salts containing anions such as citrate , succinate and phosphate that are high in the hofmeister series . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
187,
193
]
} | {
"id": "C0031603",
"name": "phosphate",
"pos": [
226,
235
]
} |
when dl-alpha-monofluoromethylputrescine is used in combination with dl-alpha-difluoromethylarginine ( r.m.i . 71897 ) , an irreversible inhibitor of arginine decarboxylase , in vivo in e. coli , both decarboxylase activities are inhibited ( greater than 95 % ) but putrescine levels are only decreased to about one-thir... | NA | {
"id": "C0034170",
"name": "putrescine",
"pos": [
30,
40
]
} | {
"id": "C0037871",
"name": "levels",
"pos": [
355,
361
]
} |
tunicamycin blocked glycosylation of pro-c4 , c2 and factor b and inhibited secretion of the corresponding native complement proteins synthesized by guinea-pig peritoneal macrophages in tissue culture . | NA | {
"id": "C0033453",
"name": "factor b",
"pos": [
53,
61
]
} | {
"id": "C0009498",
"name": "complement proteins",
"pos": [
114,
133
]
} |
acetyl-coa : l-glutamate n-acetyltransferase ( amino acid acetyltransferase , ec 2.3.1.1 ) was isolated from human liver mitochondria by precipitation with ( nh4 ) 2so4 and chromatography on hydroxyapatite , deae-cellulose and sephacryl 300 . | NA | {
"id": "C0001068",
"name": "acetyltransferase",
"pos": [
27,
44
]
} | {
"id": "C0051612",
"name": "amino acid acetyltransferase",
"pos": [
47,
75
]
} |
when cellulose replaced the cellobiose , the cell-free culture filtrate contained only low-molecular-weight enzyme ( m ( r ) approx . 30000 ) in late-stationary-phase cultures ( 7 days ) . | NA | {
"id": "C0007648",
"name": "cellulose",
"pos": [
5,
14
]
} | {
"id": "C0007630",
"name": "cellobiose",
"pos": [
28,
38
]
} |
papaya peptidase a resembles ficin ( ec 3.4.22.3 ) and actinidin ( the cysteine proteinase from actinidin chinenis ) in that it does not appear to possess a carboxy group able to influence the reactivity of the thiol group by change of ionization state at ph values of about 4 , a situation that contrasts markedly with ... | NA | {
"id": "C0030940",
"name": "peptidase",
"pos": [
7,
16
]
} | {
"id": "C2717970",
"name": "cysteine proteinase",
"pos": [
71,
90
]
} |
the mucin , which was eluted in the void volume , had an amino acid profile typical of a salivary mucus glycoprotein with high proportions of threonine , serine and proline ( 48.8 % of total amino acids ) , and low proportions of aromatic and basic amino acids . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
57,
67
]
} | {
"id": "C0301714",
"name": "basic amino acids",
"pos": [
243,
260
]
} |
this inhibition was reversed by putrescine , spermidine and spermine , and at last partially by several other diamines and polyamine homologues . | NA | {
"id": "C0011957",
"name": "diamines",
"pos": [
110,
118
]
} | {
"id": "C0032433",
"name": "polyamine",
"pos": [
123,
132
]
} |
the amounts of endogenous mono ( adp ribose ) -protein conjugates and their hydroxyl-amine-sensitive and hydroxylamine-resistant subfractions in various tissues of the mouse were determined and compared with poly ( adp-ribose ) conjugates . | NA | {
"id": "C0001461",
"name": "adp ribose",
"pos": [
33,
43
]
} | {
"id": "C0032403",
"name": "poly",
"pos": [
208,
212
]
} |
total mono- ( adp-ribose ) conjugates did not correlate with poly ( adp-ribose ) residues or the cellularity of a tissue , but were related to the protein content and the amounts of nad+ +nadh . | NA | {
"id": "C0001461",
"name": "adp-ribose",
"pos": [
14,
24
]
} | {
"id": "C0032403",
"name": "poly",
"pos": [
61,
65
]
} |
this effect was tested by both measuring the incorporation of radioactivity into phosphatidylcholine in cells labelled with [ me- ( 14 ) c ] choline , and by assaying the activity of cdp-choline : diacylglycerol cholinephosphotransferase . | NA | {
"id": "C0008405",
"name": "choline",
"pos": [
93,
100
]
} | {
"id": "C0010725",
"name": "cdp-choline",
"pos": [
183,
194
]
} |
drugs which enhanced na , k-atpase activity -- noradrenaline , adrenaline and oxymethazoline -- were found to inhibit endogenous membrane lipid peroxidation . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
47,
60
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
63,
73
]
} |
studies of the amount of platinum bound to dna in tumour and marrow following administration of the two drugs revealed that the improved selectivity of pt [ ohmal ( nh3 ) 2 ] was associated with a selective increase in the amount of platinum bound to tumour dna , relative to cisplatin . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
43,
46
]
} | {
"id": "C0012930",
"name": "tumour dna",
"pos": [
251,
261
]
} |
patients with rheumatoid arthritis and systemic lupus erythematosus had levels of pepsinogen i similar to controls , whereas patients with sjogren 's syndrome had levels significantly lower than either controls ( p less than 0.001 ) or patients with rheumatic diseases not associated with sicca syndrome ( p less than 0.... | NA | {
"id": "C0003873",
"name": "rheumatoid arthritis",
"pos": [
14,
34
]
} | {
"id": "C1527336",
"name": "sjogren 's syndrome",
"pos": [
139,
158
]
} |
while the concentration of isosorbide 2-mononitrate remained stable , the concentration of isosorbide dinitrate and of isosorbide 5-mononitrate in plasma increased gradually during the first days of administration . | NA | {
"id": "C0022252",
"name": "isosorbide",
"pos": [
27,
37
]
} | {
"id": "C0064079",
"name": "isosorbide 5-mononitrate",
"pos": [
119,
143
]
} |
the main difference observed between administration of free oestrone or oestradiol and of conjugated oestrogens ( oestrone sulfate or equine oestrogens ) was a much more protracted influx of oestrogens from the intestine into the plasma compartment , with a tendency to more sustained plasma levels , if conjugated oestr... | NA | {
"id": "C0014939",
"name": "oestrogens",
"pos": [
101,
111
]
} | {
"id": "C0014938",
"name": "conjugated oestrogens",
"pos": [
304,
325
]
} |
c-reactive protein and four other acute phase reactant proteins of non-cardiac , origin ( orosomucoid , alpha 1- antitrypsin , heptoglobin , and alpha 2- macroglobulin ) were studied serially by laser immunonephelometric assay in sera from 17 patients with myocardial infarction . | NA | {
"id": "C0006560",
"name": "c-reactive protein",
"pos": [
0,
18
]
} | {
"id": "C0001347",
"name": "acute phase reactant",
"pos": [
34,
54
]
} |
c-reactive protein and four other acute phase reactant proteins of non-cardiac , origin ( orosomucoid , alpha 1- antitrypsin , heptoglobin , and alpha 2- macroglobulin ) were studied serially by laser immunonephelometric assay in sera from 17 patients with myocardial infarction . | NA | {
"id": "C0001347",
"name": "acute phase reactant",
"pos": [
34,
54
]
} | {
"id": "C0029297",
"name": "orosomucoid",
"pos": [
90,
101
]
} |
c-reactive protein and four other acute phase reactant proteins of non-cardiac , origin ( orosomucoid , alpha 1- antitrypsin , heptoglobin , and alpha 2- macroglobulin ) were studied serially by laser immunonephelometric assay in sera from 17 patients with myocardial infarction . | NA | {
"id": "C0001347",
"name": "acute phase reactant",
"pos": [
34,
54
]
} | {
"id": "C0002191",
"name": "alpha 1",
"pos": [
104,
111
]
} |
2 absorption of enalapril maleate ( 10 mg , p.o . ) was rapid , with peak serum concentrations of enalapril observed 0.5-1.5 h after administration . | NA | {
"id": "C0700452",
"name": "enalapril maleate",
"pos": [
16,
33
]
} | {
"id": "C0014025",
"name": "enalapril",
"pos": [
98,
107
]
} |
results suggest that the drug is more toxic for earlier haemopoietic progenitor cells than for the more mature cells , and that the latter are not reliable parameters for complete haemopoietic recovery in mice after treatment with this agent . | NA | {
"id": "C0018956",
"name": "haemopoietic progenitor cells",
"pos": [
56,
85
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
111,
116
]
} |
the incorporation of the labelled deoxyribonucleosides 3h-deoxythymidine ( 3h-tdr ) , h3-deoxycytidine ( 3h-cdr ) , 3h-deoxyadenosine ( 3h-adr ) , 3h-deoxyguanosine ( 3g-gdr ) , 3h-deoxyuridine ( 3h-udr ) and of labelled uridine ( 3h-ur ) into dna and rna was studied in bone marrow ( bm ) and peripheral blood ( pb ) ce... | NA | {
"id": "C0011528",
"name": "deoxyribonucleosides",
"pos": [
34,
54
]
} | {
"id": "C0040077",
"name": "tdr",
"pos": [
78,
81
]
} |
the incorporation of the labelled deoxyribonucleosides 3h-deoxythymidine ( 3h-tdr ) , h3-deoxycytidine ( 3h-cdr ) , 3h-deoxyadenosine ( 3h-adr ) , 3h-deoxyguanosine ( 3g-gdr ) , 3h-deoxyuridine ( 3h-udr ) and of labelled uridine ( 3h-ur ) into dna and rna was studied in bone marrow ( bm ) and peripheral blood ( pb ) ce... | NA | {
"id": "C0011528",
"name": "deoxyribonucleosides",
"pos": [
34,
54
]
} | {
"id": "C0011503",
"name": "deoxyguanosine",
"pos": [
150,
164
]
} |
the incorporation of the labelled deoxyribonucleosides 3h-deoxythymidine ( 3h-tdr ) , h3-deoxycytidine ( 3h-cdr ) , 3h-deoxyadenosine ( 3h-adr ) , 3h-deoxyguanosine ( 3g-gdr ) , 3h-deoxyuridine ( 3h-udr ) and of labelled uridine ( 3h-ur ) into dna and rna was studied in bone marrow ( bm ) and peripheral blood ( pb ) ce... | NA | {
"id": "C0011528",
"name": "deoxyribonucleosides",
"pos": [
34,
54
]
} | {
"id": "C0011535",
"name": "deoxyuridine",
"pos": [
181,
193
]
} |
culture studies of peripheral blood mononuclear cells from seven typical cases of b-cell chronic lymphatic leukaemia ( cll ) showed that , in the presence of pha or con a and greater than or equal to 20 % autologous or allogeneic t-cells , cll cells express true sheep erythrocyte ( e ) receptor after 2-5 d , but fail t... | NA | {
"id": "C1321301",
"name": "peripheral blood mononuclear cells",
"pos": [
19,
53
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
244,
249
]
} |
culture studies of peripheral blood mononuclear cells from seven typical cases of b-cell chronic lymphatic leukaemia ( cll ) showed that , in the presence of pha or con a and greater than or equal to 20 % autologous or allogeneic t-cells , cll cells express true sheep erythrocyte ( e ) receptor after 2-5 d , but fail t... | NA | {
"id": "C3485979",
"name": "allogeneic",
"pos": [
219,
229
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
244,
249
]
} |
we have investigated the role of poly ( adenosine diphosphate ribose ) in dna repair in human fibroblasts by observing the effects of 3-aminobenzamide ( 3ab ) , a specific inhibitor of poly ( adp-ribose ) synthesis , on various aspects of dna repair . | NA | {
"id": "C0032403",
"name": "poly ( adenosine diphosphate ribose",
"pos": [
33,
68
]
} | {
"id": "C0001461",
"name": "adp-ribose",
"pos": [
192,
202
]
} |
the enzyme utilized starch , amylose , and glycogen as primers with equal efficiency whereas dextrin , amylopectin , maltotriose , and maltose were less effective as primers . | NA | {
"id": "C0038179",
"name": "starch",
"pos": [
20,
26
]
} | {
"id": "C0002732",
"name": "amylose",
"pos": [
29,
36
]
} |
the enzyme utilized starch , amylose , and glycogen as primers with equal efficiency whereas dextrin , amylopectin , maltotriose , and maltose were less effective as primers . | NA | {
"id": "C0038179",
"name": "starch",
"pos": [
20,
26
]
} | {
"id": "C0002728",
"name": "amylopectin",
"pos": [
103,
114
]
} |
these results suggest that the first step in the metabolism of thiocystine by e. coli involves the beta elimination of pyruvate . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
49,
59
]
} | {
"id": "C0221102",
"name": "elimination",
"pos": [
104,
115
]
} |
bleomycin cleavage sites and phleomycin cleavage sites are a subset of sites cleaved in reactions containing tallysomycin a . | NA | {
"id": "C0005740",
"name": "bleomycin",
"pos": [
0,
9
]
} | {
"id": "C0031559",
"name": "phleomycin",
"pos": [
29,
39
]
} |
the binding of adp to the enzyme and its complexes with single-stranded ( ss ) dna and double-stranded ( ds ) dna has been measured by equilibrium dialysis . | NA | {
"id": "C0012935",
"name": "single-stranded",
"pos": [
56,
71
]
} | {
"id": "C0012854",
"name": "double-stranded",
"pos": [
87,
102
]
} |
from the circular dichroism spectra it can be concluded that the 7-deazapurine nucleotide is much more flexible than the purine nucleotide . | NA | {
"id": "C0028630",
"name": "nucleotide",
"pos": [
79,
89
]
} | {
"id": "C0034137",
"name": "purine nucleotide",
"pos": [
121,
138
]
} |
it was determined that the fluorescence emission of probes at the tpp-protectable site is very low due to energy transfer to the fad coenzyme and that this fluorescence is greatly enhanced upon reduction or extraction of the flavin . | NA | {
"id": "C0039848",
"name": "tpp",
"pos": [
66,
69
]
} | {
"id": "C0009235",
"name": "coenzyme",
"pos": [
133,
141
]
} |
peptide maps of bovine brain tubulin and the associated [ 32p ] adp-ribosylated proteins showed a correspondence between the autoradiographic images and the stained peptide fragments . | NA | {
"id": "C0030956",
"name": "peptide",
"pos": [
0,
7
]
} | {
"id": "C0030935",
"name": "peptide",
"pos": [
165,
172
]
} |
the hydroxamic acid was extracted from lyophilized culture media with ethanol and methanol and crystallized as the hydrochloride . | NA | {
"id": "C0001962",
"name": "ethanol",
"pos": [
70,
77
]
} | {
"id": "C0001963",
"name": "methanol",
"pos": [
82,
90
]
} |
polylysine induced aggregation and appreciable fusion at charge ratios ( polylysine/phospholipid ) of 0.5-2 , while divalent cations did so only at charge ratios ( cation/phospholipid ) greater than 10 . | NA | {
"id": "C0007448",
"name": "divalent cations",
"pos": [
116,
132
]
} | {
"id": "C0007447",
"name": "cation",
"pos": [
164,
170
]
} |
( 6 ) although standard procedures of membrane preparations not involving density gradient separation provide membranes of reasonable purity for the estimation of lipid components , we consider the final purification step of density gradient separation using percolltm is essential for determining small quantitative cha... | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
163,
168
]
} | {
"id": "C0025249",
"name": "membrane lipid",
"pos": [
350,
364
]
} |
sds-polyacrylamide gel electrophoresis revealed an abnormal migration of the phosphoprotein and its enzymatically dephosphorylated derivative in comparison to standard proteins . | NA | {
"id": "C0031689",
"name": "phosphoprotein",
"pos": [
77,
91
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
168,
176
]
} |
we conclude , then , that the glucose 6-hydroxymethyl group ( which binds to an aspartic acid and a serine ) is essential for the hexose-induced conformational change . | NA | {
"id": "C0017725",
"name": "glucose",
"pos": [
30,
37
]
} | {
"id": "C0019494",
"name": "hexose",
"pos": [
130,
136
]
} |
interactions between the molybdenum-iron protein ( kp1 ) of nitrogenase ( reduced ferredoxin : dinitrogen oxidoreductase ( atp-hydrolysing , ) ec 1.18.2.1 ) from klebsiella pneumoniae and the divalent ions , mn2+ , mg2+ , ca2+ and ba2+ , have been studied by monitoring the water proton nmr relaxation enhancement caused... | NA | {
"id": "C0026404",
"name": "molybdenum-iron protein",
"pos": [
25,
48
]
} | {
"id": "C0015858",
"name": "ferredoxin",
"pos": [
82,
92
]
} |
interactions between the molybdenum-iron protein ( kp1 ) of nitrogenase ( reduced ferredoxin : dinitrogen oxidoreductase ( atp-hydrolysing , ) ec 1.18.2.1 ) from klebsiella pneumoniae and the divalent ions , mn2+ , mg2+ , ca2+ and ba2+ , have been studied by monitoring the water proton nmr relaxation enhancement caused... | NA | {
"id": "C0028174",
"name": "nitrogenase",
"pos": [
60,
71
]
} | {
"id": "C0030016",
"name": "oxidoreductase",
"pos": [
106,
120
]
} |
the enzyme was inhibited competitively by bestatin ( ki 10-7 m ) and by captopril ( 2.5.10-7 m , d-3-thio-2-methylpropanyl proline ) and by low concentrations of zn2+ or pcmb , and at higher concentrations by tpck and pmsf . | NA | {
"id": "C0006938",
"name": "captopril",
"pos": [
72,
81
]
} | {
"id": "C0033382",
"name": "proline",
"pos": [
123,
130
]
} |
the enhanced action of captopril was attributed to the presence of the -sh and -ch3 groups , since inhibition was shared by di- and tripeptides with proline in positions 2 and 3 . | NA | {
"id": "C0006938",
"name": "captopril",
"pos": [
23,
32
]
} | {
"id": "C0033382",
"name": "proline",
"pos": [
149,
156
]
} |
neither free fatty acids nor acyl-coa derivatives served as acyl donor but some of the constituent fatty acids of exogenous phosphatidylethanolamine were recovered among the amide-linked fatty acids of the n-acylethanolamine phospholipids . | NA | {
"id": "C0015688",
"name": "free fatty acids",
"pos": [
8,
24
]
} | {
"id": "C0015684",
"name": "fatty",
"pos": [
187,
192
]
} |
the effect of 3-mercaptopicolinic acid and substrate interactions on the incorporation of lipogenic precursors into glyceride-glycerol , glyceride-fatty acids and nonesterified fatty acids in bovine adipose tissue . | NA | {
"id": "C0015684",
"name": "fatty",
"pos": [
147,
152
]
} | {
"id": "C0015688",
"name": "nonesterified fatty acids",
"pos": [
163,
188
]
} |
glucose doubled the incorporation of lactate into glyceride-fatty acids , but had no effect on the net incorporation of lactate into nonesterified fatty acids . | NA | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
60,
71
]
} | {
"id": "C0015688",
"name": "nonesterified fatty acids",
"pos": [
133,
158
]
} |
studies on the uptake of [ me-14c ] choline and its incorporation into its metabolites over a 5 h period indicated that in these cells the cholinephosphate pool was much larger than both the choline and cdpcholine pool . | NA | {
"id": "C0031716",
"name": "cholinephosphate",
"pos": [
139,
155
]
} | {
"id": "C0008405",
"name": "choline",
"pos": [
206,
213
]
} |
studies on the uptake of [ me-14c ] choline and its incorporation into its metabolites over a 5 h period indicated that in these cells the cholinephosphate pool was much larger than both the choline and cdpcholine pool . | NA | {
"id": "C0008405",
"name": "choline",
"pos": [
36,
43
]
} | {
"id": "C0010725",
"name": "cdpcholine",
"pos": [
203,
213
]
} |
[ me-14c ] choline taken up by the cells was rapidly converted into cholinephosphate during the pulse period . | NA | {
"id": "C0008405",
"name": "choline",
"pos": [
11,
18
]
} | {
"id": "C0031716",
"name": "cholinephosphate",
"pos": [
68,
84
]
} |
the composition of the individual free fatty acids of the liver triacylglycerols showed a shift towards the shorter fatty acids and the nutritionally essential alpha-linolenic acid in clofibrate-treated mice . | NA | {
"id": "C0015688",
"name": "free fatty acids",
"pos": [
34,
50
]
} | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
116,
127
]
} |
the initial rate of filipin association with unesterified cholesterol in high density lipoproteins ( hdl ) was measured by stopped-flow spectrophotometry to assess the roles played by apolipoproteins and phospholipids in modulating the surface exposure of cholesterol . | NA | {
"id": "C0023822",
"name": "cholesterol",
"pos": [
58,
69
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
256,
267
]
} |
a simple method was developed for the rapid determination of [ 14c ] phosphatidylcholine transfer from small unilamellar liposomes to human plasma hdl , based on the selective precipitation of liposomes by heparin and mncl2 . | NA | {
"id": "C1721091",
"name": "unilamellar liposomes",
"pos": [
109,
130
]
} | {
"id": "C0023828",
"name": "liposomes",
"pos": [
193,
202
]
} |
acyltransferase assays indicated that enzyme distribution is skewed to larger-sized hdl3 , suggesting that the non-transferable components might be lecithin : cholesterol acyltransferase-containing parent complexes , while the smaller transfer products contain little acyltransferase . | NA | {
"id": "C0008380",
"name": "cholesterol",
"pos": [
159,
170
]
} | {
"id": "C0001390",
"name": "acyltransferase",
"pos": [
268,
283
]
} |
amino acid composition data indicated high contents of aspartic acid , glycine and alanine in both enzymes . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
0,
10
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
71,
78
]
} |
amino acid composition data indicated high contents of aspartic acid , glycine and alanine in both enzymes . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
0,
10
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
83,
90
]
} |
these results indicate that intestinal epithelial cells possess a receptor that interacts with atp and other adenine nucleotides and that receptor occupation by atp causes activation of adenylate cyclase , increased cyclic amp and changes in active ion transport across intestinal mucosa . | NA | {
"id": "C0001413",
"name": "adenine nucleotides",
"pos": [
109,
128
]
} | {
"id": "C0001455",
"name": "cyclic amp",
"pos": [
216,
226
]
} |
these results show that the absence of nahco3 specifically inhibits the glycogenic action of glucocorticoids in cultured fetal rat hepatocytes and indicate the need for further investigation into the role of hco3- in universally used bicarbonate-buffered media . | NA | {
"id": "C0074722",
"name": "nahco3",
"pos": [
39,
45
]
} | {
"id": "C0005367",
"name": "bicarbonate",
"pos": [
234,
245
]
} |
it seems to reflect conformational changes induced by the binding of two mg2+ ions to the protein molecule which results in a transfer of some tryptophan residues from the protein surface into an interior part of the protein in rigid unpolar environment . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
90,
97
]
} | {
"id": "C0025252",
"name": "protein surface",
"pos": [
172,
187
]
} |
the model is shown to give a satisfactory description of fractionation of carbon isotopes in heterotrophs and to be insufficient for describing isotope fractionation in autotrophs . | NA | {
"id": "C0007017",
"name": "carbon isotopes",
"pos": [
74,
89
]
} | {
"id": "C0022262",
"name": "isotope",
"pos": [
144,
151
]
} |
the kinetics of the thermal inactivation follow the first order for cellobiase of asp . foetidus alone and show a more complex picture which is typical for a number of isoenzymes of different thermal stabilities for other cellulolytic components of all the cellulases under study . | NA | {
"id": "C0005223",
"name": "cellobiase",
"pos": [
68,
78
]
} | {
"id": "C1260229",
"name": "cellulases",
"pos": [
257,
267
]
} |
aromatic amino acids including iodotyrosines and thyroxin in intact , extraiodinated and acetylated bovine thyroglobulin were studied by the differential spectrophotometric technique . | NA | {
"id": "C0301713",
"name": "aromatic amino acids",
"pos": [
0,
20
]
} | {
"id": "C0040165",
"name": "thyroxin",
"pos": [
49,
57
]
} |
the following were found to express affinities relative to cortisol which was considered to be 100 : corticosterone ( 100 ) , progesterone ( 10 ) , cortisone ( 8 ) , 5 alpha-pregnane-3 , 20-dione ( 2 ) , and 20 alpha-hydroxy-4-pregnen-3-one ( less than 1 ) . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
126,
138
]
} | {
"id": "C0012311",
"name": "20 alpha-hydroxy-4-pregnen-3-one",
"pos": [
208,
240
]
} |
no competition was found for dexamethasone , betamethasone , triamcinolone , triamcinolone acetonide , r5020 , medroxyprogesterone acetate , estrone or estradiol . | NA | {
"id": "C0040864",
"name": "triamcinolone",
"pos": [
61,
74
]
} | {
"id": "C0040866",
"name": "triamcinolone",
"pos": [
77,
90
]
} |
in addition , human serum did not induce acrosomal loss when pretreated with antiserum to complement component c8 , suggesting that acrosomal loss in unheated serum is caused by the membrane attack complex of complement . | NA | {
"id": "C0009498",
"name": "complement",
"pos": [
90,
100
]
} | {
"id": "C0009545",
"name": "membrane attack complex",
"pos": [
182,
205
]
} |
human serum complement anaphylatoxins did not induce acrosomal loss , although they are known to induce exocytosis of secretory granules in other cell types . | NA | {
"id": "C0009498",
"name": "complement",
"pos": [
12,
22
]
} | {
"id": "C0002791",
"name": "anaphylatoxins",
"pos": [
23,
37
]
} |
aspiration of the first metatarsophalangeal joint in asymptomatic hyperuticemic psoriasis was performed in order to see whether there are specific findings which could help to predict who is prone to develop gout and to find out whether a distinction can be established between psoriasis and gouty arthritis . | NA | {
"id": "C0018099",
"name": "gout",
"pos": [
208,
212
]
} | {
"id": "C0003868",
"name": "gouty arthritis",
"pos": [
292,
307
]
} |
the adsorption of protein on red cell surface was studied by the measurement of protein in plasma and incubation of blood with 131i-albumin . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
18,
25
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
132,
139
]
} |
nerve stimulation has led to accumulation of myocardial adrenaline which takes part in realization of a positive inotropic effect to a far less extent than noradrenaline , and exerts no adverse action on cardiac function . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
56,
66
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
156,
169
]
} |
species-specificity antigens , forssman antigen and antigen similar to human b-isoantigen were revealed in the cells of both the intraspecies and all interspecies hepatoma hybrids . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
20,
27
]
} | {
"id": "C0022145",
"name": "isoantigen",
"pos": [
79,
89
]
} |
in an attempt to improve the poor outlook for children with t-cell leukemia ( t-all ) , the southwest oncology group , pediatric division , used a modified lsa2-l2 multidrug regimen to treat 53 patients with e-rosette-positive t-all . | NA | {
"id": "C0023492",
"name": "t-cell leukemia",
"pos": [
60,
75
]
} | {
"id": "C0023493",
"name": "t-all",
"pos": [
227,
232
]
} |
2 in renal tubules the alpha-adrenoceptor agonists , oxymetazoline , ( -- ) -noradrenaline , ( -- ) -alpha-methylnoradrenaline and ( -- ) -phenylephrine , stimulated gluconeogenesis from pyruvate . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
77,
90
]
} | {
"id": "C0025805",
"name": "alpha-methylnoradrenaline",
"pos": [
101,
126
]
} |
5 high affinity [ 3h ] -prazosin binding could be completely displaced by the alpha-adrenoceptor agonists , oxymetazoline , ( -- ) -noradrenaline , ( -- ) -phenylephrine , and ( -- ) -alpha-methylnoradrenaline . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
132,
145
]
} | {
"id": "C0025805",
"name": "alpha-methylnoradrenaline",
"pos": [
184,
209
]
} |
contribution of prostaglandins and thromboxanes to the adenosine and atp-induced contraction of guinea-pig isolated trachea . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
55,
64
]
} | {
"id": "C0001480",
"name": "atp",
"pos": [
69,
72
]
} |
an intense discharge of slow waves then occurred as the tension rapidly rose again towards the pre-cooling value.4 sodium nitrite , ( - ) -isoprenaline , adenosine and adenosine triphosphate ( atp ) each evoked relaxation and reduced the frequency and amplitude of slow waves . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
154,
163
]
} | {
"id": "C0001480",
"name": "adenosine triphosphate",
"pos": [
168,
190
]
} |
fifteen patients had symptoms suggesting intestinal obstruction , 7 proved to have pseudo-obstruction , 4 had withdrawal symptoms , 2 had faecal impaction and only 2 had adhesions which necessitated operation . | NA | {
"id": "C0021843",
"name": "intestinal obstruction",
"pos": [
41,
63
]
} | {
"id": "C0015734",
"name": "faecal impaction",
"pos": [
138,
154
]
} |
pericapillary fibrin in the ulcer-bearing skin of the leg : the cause of lipodermatosclerosis and venous ulceration . | NA | {
"id": "C0023223",
"name": "ulcer",
"pos": [
28,
33
]
} | {
"id": "C0042344",
"name": "venous ulceration",
"pos": [
98,
115
]
} |
a study in an inner city area of the effects of a national television campaign about child accident prevention and of a locally designed health education initiative showed that 55 % of families with young children in the study area did not watch any of the television programmes . | NA | {
"id": "C0008059",
"name": "child",
"pos": [
85,
90
]
} | {
"id": "C0728836",
"name": "young children",
"pos": [
199,
213
]
} |
a sequence of 15 questions is used to analyse pain , headache and facial pain being used for illustration . | NA | {
"id": "C0030193",
"name": "pain",
"pos": [
46,
50
]
} | {
"id": "C0018681",
"name": "headache",
"pos": [
53,
61
]
} |
a sequence of 15 questions is used to analyse pain , headache and facial pain being used for illustration . | NA | {
"id": "C0030193",
"name": "pain",
"pos": [
46,
50
]
} | {
"id": "C0015468",
"name": "facial pain",
"pos": [
66,
77
]
} |
considering that a well-defined dopaminergic projection from the mesencephalic structures to the rat frontal cortex has been demonstrated , the purpose of this research was to study the action of iontophoretically applied dopamine ( da ) on intracellularly recorded rat frontal neurons . | NA | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
32,
44
]
} | {
"id": "C0013030",
"name": "dopamine",
"pos": [
222,
230
]
} |
sp-free acid and a series of 11 sp analogues , in which each amino acid of sp is replaced in turn by l-alanine , all inhibited the nicotine-induced release of [ 3h ] ne from these cultures . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
61,
71
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
103,
110
]
} |
it was proposed that depletion of norepinephrine or epinephrine was the cause of the behavioral abnormality . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
34,
48
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
52,
63
]
} |
we conclude that some of the neurons protected by local injection of amphetamine and dmi are probably norepinephrine or epinephrine fibers that ascend through the ventral midbrain and have as one of their functions the inhibition of food intake . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
102,
116
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
120,
131
]
} |
these results provide biochemical evidence in support of previous anatomical and physiological data , for an interaction between the brain vasopressin and angiotensin systems in discrete hypothalamic nuclei , and suggest that vasopressin could regulate the formation of brain angiotensin ii by modulating the activity of... | NA | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
155,
166
]
} | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
276,
290
]
} |
this is deduced from the lack of effect of a metabolic inhibitor and sodium-transport inhibitors on the fast component of 22na efflux ( which contrast with their effects both on the size an the half-time of the slow component ) and from the typically extracellular ratios between the fast components of substantial incre... | NA | {
"id": "C0022023",
"name": "ions",
"pos": [
341,
345
]
} | {
"id": "C0003075",
"name": "anionic",
"pos": [
544,
551
]
} |
acute effects of n-methyl-dl-aspartate on the release of pituitary gonadotropins and prolactin in the adult female rhesus monkey . | NA | {
"id": "C0018066",
"name": "pituitary gonadotropins",
"pos": [
57,
80
]
} | {
"id": "C0033371",
"name": "prolactin",
"pos": [
85,
94
]
} |
these results suggest that dopamine receptor sites labeled by lisuride are at least in part sodium-dependent , possibly the d2-receptors not involved in adenylate cyclase stimulation . | NA | {
"id": "C0034798",
"name": "dopamine receptor sites",
"pos": [
27,
50
]
} | {
"id": "C0058698",
"name": "d2-receptors",
"pos": [
124,
136
]
} |
brain and anterior pituitary growth hormone ( gh ) , thyroid-stimulating hormone ( tsh ) and luteinizing hormone ( lh ) were measured during fetal , neonatal , and pubertal life and into adulthood . | NA | {
"id": "C0032016",
"name": "anterior pituitary",
"pos": [
10,
28
]
} | {
"id": "C0037663",
"name": "gh",
"pos": [
46,
48
]
} |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.