text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
brain and anterior pituitary growth hormone ( gh ) , thyroid-stimulating hormone ( tsh ) and luteinizing hormone ( lh ) were measured during fetal , neonatal , and pubertal life and into adulthood . | NA | {
"id": "C0032016",
"name": "anterior pituitary",
"pos": [
10,
28
]
} | {
"id": "C0040160",
"name": "tsh",
"pos": [
83,
86
]
} |
plasma lipoprotein concentration as an indicator of fatness in broilers : development and use of a simple assay for plasma very low density lipoproteins . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
7,
18
]
} | {
"id": "C0023825",
"name": "very low density lipoproteins",
"pos": [
123,
152
]
} |
cultivated animal cells ( mouse peritoneal macrophages , chick fibroblasts or mouse ehrlich tumor cells ) or zea mays root tips are treated with cis-pt ( ii ) . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
63,
74
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
98,
103
]
} |
in a double-blind trial on 20 human volunteers , the duration of intradermal anaesthesia with bupivacaine 0.25 per cent was compared with duration with a mixture of bupivacaine 0.25 per cent and carbonated lidocaine 1.0 per cent and with a mixture of bupivacaine 0.25 per cent and lidocaine hydrochloride 1.0 per cent . | NA | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
206,
215
]
} | {
"id": "C0546869",
"name": "lidocaine hydrochloride",
"pos": [
281,
304
]
} |
the duration of intradermal anaesthesia produced by bupivacaine mixed with carbonated lidocaine was 114 +/- 56 ( mean +/- 1 sd ) minutes and was not significantly shorter than the duration of the bupivacaine alone , at 125 +/- 70 minutes , or duration with the mixture of bupivacaine and lidocaine hydrochloride , which ... | NA | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
86,
95
]
} | {
"id": "C0546869",
"name": "lidocaine",
"pos": [
288,
297
]
} |
these results indicate that the mixture of bupivacaine with either carbonated lidocaine or lidocaine hydrochloride may be used for local anaesthesia without significant shortening of the duration of action . | NA | {
"id": "C0023660",
"name": "lidocaine",
"pos": [
78,
87
]
} | {
"id": "C0546869",
"name": "lidocaine",
"pos": [
91,
100
]
} |
furthermore , the rate of metabolism and excretion of an organomercurial will greatly influence its neural toxicity . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
26,
36
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
41,
50
]
} |
levels of cholesterol ( both free and esterified ) in plasma were 175-725 % greater in animals consuming 0.5 % dietary cholesterol and 30-105 % greater in gerbils ingesting 0.1 % cholesterol as compared with levels in gerbils fed a basal ( unsupplemented ) diet . | NA | {
"id": "C0008395",
"name": "dietary cholesterol",
"pos": [
111,
130
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
179,
190
]
} |
the porphyrin-inducing steroids , 3 alpha-hydroxy-5 alpha-pregnane-11,20-dione ( alfaxalone ) and 3 alpha-hydroxy-5 alpha-pregnan-20-one induce considerably greater fluidity changes in spin-labelled phospholipid-cholesterol bilayers than do the corresponding 3 beta-hydroxy steroids which are also less potent as porphyr... | NA | {
"id": "C0033006",
"name": "pregnane",
"pos": [
58,
66
]
} | {
"id": "C0038317",
"name": "steroids",
"pos": [
274,
282
]
} |
escherichia coli lipopolysaccharide ( endotoxin ) alters the stability of erythrocytes to hypotonic lysis although the nature and magnitude of the effect varied with temperature and with the type of red blood cell examined . | NA | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
17,
35
]
} | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
38,
47
]
} |
solutions at various ph values , at two temperatures , and in polyethylene glycol ( peg-400 ) , were assessed by high-pressure liquid chromatography for indomethacin and its products . | NA | {
"id": "C0032483",
"name": "polyethylene glycol",
"pos": [
62,
81
]
} | {
"id": "C0032478",
"name": "peg-400",
"pos": [
84,
91
]
} |
most significant was the finding of evidence of a second tumor type in nine of the 35 tumors previously classified as moderately to well differentiated thus reclassifying them as mixed tumors . | NA | {
"id": "C0085183",
"name": "second tumor",
"pos": [
50,
62
]
} | {
"id": "C0027651",
"name": "tumors",
"pos": [
185,
191
]
} |
however , plasma levels of anti-xa were often low ( less than 70 % ) and increased only in the presence of heparin . | NA | {
"id": "C0019139",
"name": "anti-xa",
"pos": [
27,
34
]
} | {
"id": "C0019134",
"name": "heparin",
"pos": [
107,
114
]
} |
to determine the basis of this heterogeneity , cells from spontaneous tumors and from five subpopulations isolated from a single spontaneous tumor were examined for expression of viral antigens under both conventional conditions and conditions known to induce synthesis of murine mammary tumor virus antigens ( 5-iodo-2'... | NA | {
"id": "C0003342",
"name": "viral antigens",
"pos": [
179,
193
]
} | {
"id": "C0003320",
"name": "antigens",
"pos": [
300,
308
]
} |
light and electron microscopic examination revealed the highest proportion of epithelial cells in the lighter bands and an increase in granulocytes and fibroblasts in the heavier bands , suggesting a nonepithelial contribution . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
52,
55
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
152,
163
]
} |
morris 7777 hepatoma cells , maintained in culture for 5 days in lewis medium supplemented with 0.1 to 0.35 mm cis-unsaturated fatty acid of the oleic ( number of carbon atoms : number of double bonds , 18:1 ) , linoleic ( 18:2 ) , or arachidonic ( 20:4 ) type , were compared to similarly maintained , unsupplemented ce... | NA | {
"id": "C0015690",
"name": "unsaturated fatty acid",
"pos": [
115,
137
]
} | {
"id": "C0015684",
"name": "fatty acid",
"pos": [
349,
359
]
} |
parallel in vivo studies revealed cross-resistance of various degrees among a number of anthracycline analogs , complete cross-resistance among daunorubicin , doxorubicin , and 4'- ( 9-acridinylamino ) methanesulfon-m-anisidine ( amsacrine ) , and partial cross-resistance between daunorubicin and etoposide . | NA | {
"id": "C0013089",
"name": "doxorubicin",
"pos": [
159,
170
]
} | {
"id": "C0011015",
"name": "daunorubicin",
"pos": [
281,
293
]
} |
the three human pancreatic rnases were immunologically identical but differed from human liver rnase , as shown by ouchterlony double-diffusion test . | NA | {
"id": "C0035541",
"name": "pancreatic rnases",
"pos": [
16,
33
]
} | {
"id": "C0014241",
"name": "rnase",
"pos": [
95,
100
]
} |
radioimmunoassay of human pancreatic rnase showed that immunologically similar rnases are present in human saliva , and serum . | NA | {
"id": "C0035541",
"name": "pancreatic rnase",
"pos": [
26,
42
]
} | {
"id": "C0014241",
"name": "rnases",
"pos": [
79,
85
]
} |
placental-type alp isoenzyme ( regan enzyme ) was observed only in grade ii and grade iii dysplasias and carcinomas . | NA | {
"id": "C0022173",
"name": "isoenzyme",
"pos": [
19,
28
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
37,
43
]
} |
cefotaxime , moxalactam , cefoperazone , ceftizoxime , ceftazidime , cefsulodin , and ceftriaxone were used to treat 102 patients hospitalized with orthopedic infections . | NA | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
0,
10
]
} | {
"id": "C0007560",
"name": "ceftizoxime",
"pos": [
41,
52
]
} |
cefotaxime , moxalactam , cefoperazone , ceftizoxime , ceftazidime , cefsulodin , and ceftriaxone were used to treat 102 patients hospitalized with orthopedic infections . | NA | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
0,
10
]
} | {
"id": "C0007561",
"name": "ceftriaxone",
"pos": [
86,
97
]
} |
[ blood pressure response to swimming in icy and warm water in individuals adapted to cold ] . | NA | {
"id": "C0020746",
"name": "icy",
"pos": [
41,
44
]
} | {
"id": "C0043047",
"name": "water",
"pos": [
54,
59
]
} |
antiserum produced in rabbits against purified myelin contains antibodies that bind to the surface of cells having multiple branched processes in live cultures of cerebral hemispheres of newborn rats . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
0,
9
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
63,
73
]
} |
the bundles of cytokeratin and vimentin filaments progressively unravel into protofilament-like threads of 2-4 nm diameter , and intermediate filament protein is included in numerous , variously sized ( 0.2-1.5 microns ) spheroidal aggregates containing densely stained granular particles of 5-16 nm diameter . | NA | {
"id": "C0010803",
"name": "cytokeratin",
"pos": [
15,
26
]
} | {
"id": "C0021769",
"name": "intermediate filament protein",
"pos": [
129,
158
]
} |
in contrast to the compaction of the viral dna in minichromosomes , the length of these beaded structures is roughly the same as free dna . | NA | {
"id": "C0012939",
"name": "viral dna",
"pos": [
37,
46
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
134,
137
]
} |
newly synthesized ribosomal proteins can not be found from early cleavage up to stage 26 , with the exception of s3 , l17 and l31 , which are constantly made , and protein l5 , which starts to be synthesized around stage 7 . | NA | {
"id": "C0035552",
"name": "ribosomal proteins",
"pos": [
18,
36
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
164,
171
]
} |
in vectors containing the 72 bp repeats and the beta- or delta-globin gene , the activity of the beta-globin gene was approximately 50 times greater than that of the delta-globin gene , approximating the ratio of beta and delta mrna observed in normal human bone marrow cells . | NA | {
"id": "C0005221",
"name": "beta-globin",
"pos": [
97,
108
]
} | {
"id": "C0011244",
"name": "delta-globin",
"pos": [
166,
178
]
} |
these results emphasize the primary role of cell shape in the modulation of the chondrocyte phenotype and demonstrate a reversible system for the study of gene expression . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
0,
3
]
} | {
"id": "C0225369",
"name": "chondrocyte",
"pos": [
80,
91
]
} |
fasting blood samples and maximum bicycle tests were administered prior to the program , and at 3 week intervals , for determination of serum triglyceride , cholesterol , hdl-cholesterol , ( vldl + ldl ) cholesterol , the ratio of hdl-cholesterol to total cholesterol , and vo2max . | NA | {
"id": "C0023822",
"name": "hdl-cholesterol",
"pos": [
171,
186
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
256,
267
]
} |
the growth responses of hamster dermal fibroblasts ( hdf cells ) to platelet-derived growth factor ( pdgf ) during chemical carcinogenesis in vitro were investigated . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
39,
50
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
57,
62
]
} |
normal human fibroblasts ( gm38 ) exhibited a similar ability to that of t98g cells for repair of 1'-aco-s-induced damage . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
13,
24
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
78,
83
]
} |
using xeroderma pigmentosum fibroblasts , deficient in excision repair , as controls to measure the initial rate of ( +/- ) 7 beta,8 alpha-dihydroxy-9 alpha,10 alpha-epoxy-7,8,9,10-tetrahydrobenzo [ a ] pyrene ( b [ a ] pde ) -- dna adducts removal in normal human fibroblasts , it was found that the maximum amount of c... | NA | {
"id": "C0242958",
"name": "carcinogen dna",
"pos": [
319,
333
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
448,
451
]
} |
the abbott-vp bichromatic analyzer was used for the determination of four antiepileptic drugs ( phenobarbital , phenytoin , carbamazepine , primidone ) in serum by means of a modified emit homogeneous enzyme immunoassay procedure . | NA | {
"id": "C0031412",
"name": "phenobarbital",
"pos": [
96,
109
]
} | {
"id": "C0033148",
"name": "primidone",
"pos": [
140,
149
]
} |
with lactate dehydrogenase , thirty-two of fifty specimens registered an increase in activity while with the aminotransferases , thirty-five and forty-one out of fifty specimens showed a decrease in aspartate aminotransferase and alanine aminotransferase activities , respectively . | NA | {
"id": "C0002594",
"name": "aminotransferases",
"pos": [
109,
126
]
} | {
"id": "C0004002",
"name": "aspartate aminotransferase",
"pos": [
199,
225
]
} |
we compared a turbidimetric electrophoretic method ( lipidophor ) for lipoprotein quantification with the standardized lipid research clinics ( lrc ) method . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
70,
81
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
119,
124
]
} |
the lipidophor alpha-cholesterol was significantly lower ( n = 171 specimens ) than the lrc high-density lipoprotein ( hdl ) cholesterol ( 514 vs 586 mg/l ) , and beta-cholesterol was significantly higher than the corresponding lrc low-density lipoprotein ( ldl ) cholesterol values ( 1505 vs 1409 mg/l ) . | NA | {
"id": "C0023822",
"name": "high-density",
"pos": [
92,
104
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
264,
275
]
} |
theophylline , dyphylline , caffeine , acetaminophen , salicylate , acetylsalicylate , procainamide , and n-acetylprocainamide determined in serum with a single liquid-chromatographic assay . | NA | {
"id": "C0039771",
"name": "theophylline",
"pos": [
0,
12
]
} | {
"id": "C0013360",
"name": "dyphylline",
"pos": [
15,
25
]
} |
ascorbic acid is specifically quantified by pretreating one of a pair of replicate samples with ascorbate oxidase ( ec 1.10.3.3 ) , to oxidize the ascorbic acid , then reacting both samples with fe3+-tptz and measuring the difference between the absorbances at 593 nm of the treated and untreated samples . | NA | {
"id": "C0003967",
"name": "ascorbate oxidase",
"pos": [
96,
113
]
} | {
"id": "C0030016",
"name": "ec 1",
"pos": [
116,
120
]
} |
to differentiate the two forms of cholesterol , we used kinetic calorimetry : the rate of heat output due to enzymic hydrolysis of esterified cholesterol ( the rate-determining reaction ) was subtracted from the measured heat , the difference being the heat released during the enzymic oxidation of free cholesterol ( th... | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
34,
45
]
} | {
"id": "C0008387",
"name": "esterified",
"pos": [
131,
141
]
} |
after a single extraction of the drugs from serum , chlordiazepoxide , demoxepam , n-desmethyl-chloriazepoxide , diazepam , n-desmethyldiazepam , n-desalkylflurazepam , oxazepam , and prazepam can be resolved and quantified by using a c18 reversed-phase `` '' high-performance '' '' column and a ternary-solvent gradient... | NA | {
"id": "C0012010",
"name": "diazepam",
"pos": [
113,
121
]
} | {
"id": "C0011279",
"name": "desmethyldiazepam",
"pos": [
126,
143
]
} |
enzyme immunoassay of the glycoprotein tropic hormones -- choriogonadotropin , lutropin , thyrotropin -- with solid-phase monoclonal antibody for the alpha-subunit and enzyme-coupled monoclonal antibody specific for the beta-subunit . | NA | {
"id": "C0018062",
"name": "choriogonadotropin",
"pos": [
58,
76
]
} | {
"id": "C0017963",
"name": "alpha-subunit",
"pos": [
150,
163
]
} |
monoclonal antibody technology has made it possible to produce homogeneous populations of antibodies to discrete determinants on an antigen surface . | NA | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
0,
19
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
90,
100
]
} |
several new electrochemical devices designed for detecting ammonia and carbon dioxide in physiological samples have in common the elimination of the fragile glass ph internal electrode used in the conventional severinghaus-design potentiometric gas sensors . | NA | {
"id": "C0002607",
"name": "ammonia",
"pos": [
59,
66
]
} | {
"id": "C0017110",
"name": "gas",
"pos": [
245,
248
]
} |
solid phase antibody for the irma is prepared by covalently linking a partially purified igg fraction of tsh antiserum to carbonyldiimidazole-activated microparticulate cellulose . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
12,
20
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
109,
118
]
} |
the enzyme activities and isozyme distribution of the three glycolytic regulator enzymes hexokinase , phosphofructokinase and pyruvate kinase were studied in lymphocytes of patients with chronic lymphocytic leukemia . | NA | {
"id": "C0022173",
"name": "isozyme",
"pos": [
26,
33
]
} | {
"id": "C0014442",
"name": "enzymes",
"pos": [
81,
88
]
} |
studies with the isolated abnormal albumin showed that either during storage or after incubation with trypsin ( or plasmin ) , its mobility became identical to that of normal serum albumin . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
35,
42
]
} | {
"id": "C0036773",
"name": "serum albumin",
"pos": [
175,
188
]
} |
the decrease of the abnormal albumin during storage was inhibited by addition of cortisol to serum ( 1 mol per mol serum albumin ) . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
29,
36
]
} | {
"id": "C0036773",
"name": "serum albumin",
"pos": [
115,
128
]
} |
correlations of wave and interwave latencies with a large variety of clinical variables showed that statistically significant relationships existed mainly in regard to presence or absence of brain damage and the severity of the seizure disorder , as expressed by the number of different seizure types to which a given pa... | NA | {
"id": "C0014544",
"name": "seizure disorder",
"pos": [
228,
244
]
} | {
"id": "C0036572",
"name": "seizure",
"pos": [
287,
294
]
} |
the lh and fsh responses to 100 micrograms lhrh in a combined pituitary stimulation test were compared to five normal men during infusions of somatostatin-28 ( ss-28 ) and somatostatin ( ss-14 ) and during control infusions of haemacel . | NA | {
"id": "C0074854",
"name": "somatostatin-28",
"pos": [
142,
157
]
} | {
"id": "C0037659",
"name": "somatostatin",
"pos": [
172,
184
]
} |
temporomandibular joint dysfunction should be suspected in any child who complains of recurrent otalgia in the absence of dental and otological disease . | NA | {
"id": "C0013456",
"name": "otalgia",
"pos": [
96,
103
]
} | {
"id": "C0013447",
"name": "otological disease",
"pos": [
133,
151
]
} |
the capacity of peripheral blood mononuclear ( pbm ) cells from patients with leprosy to generate immunoglobulin-secreting cells in response to pokeweed mitogen ( pwm ) was evaluated by a reverse haemolytic plaque forming cell ( pfc ) assay . | NA | {
"id": "C1321301",
"name": "peripheral blood mononuclear",
"pos": [
16,
44
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
222,
226
]
} |
co-culture of t lymphocytes from normal donors with pbm cells from lpr patients reduced the pfc response of these cells to the normal range . | NA | {
"id": "C1321301",
"name": "pbm cells",
"pos": [
52,
61
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
114,
119
]
} |
analysis of peripheral blood mononuclear cells showed no change in the proportion of e+ cells , total t determined with the monoclonal antibody ucht1 ( similar to okt3 ) and the t cell subsets : active e and t dot ( discrete esterase staining ) . | NA | {
"id": "C1321301",
"name": "peripheral blood mononuclear cells",
"pos": [
12,
46
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
88,
93
]
} |
mononuclear cells from the peripheral blood of healthy individuals were fractionated into t cells , mr+ cells , mr- cells and monocytes . | NA | {
"id": "C1321301",
"name": "mononuclear cells",
"pos": [
0,
17
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
116,
121
]
} |
immune complexes also inhibited the clearance and hepatic uptake of aggregated mouse albumin and aggregated ovalbumin . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
85,
92
]
} | {
"id": "C0029923",
"name": "ovalbumin",
"pos": [
108,
117
]
} |
t cells of the inducer and the suppressor/cytotoxic subsets were identified by the okt4 and okt8 antibodies respectively while hla-dr ( ia-like ) antigens were recognized by a conventional antiserum . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
97,
107
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
189,
198
]
} |
mononuclear cells from the blood of 26 patients with the 'autoimmune ' connective tissue disorder cryptogenic fibrosing alveolitis ( cfa ) were examined in chang cell cytotoxicity assays for their capacity to mediate antibody-dependent cell-mediated cytotoxicity ( adcc ) . | NA | {
"id": "C1321301",
"name": "mononuclear cells",
"pos": [
0,
17
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
236,
240
]
} |
while peripheral blood mononuclear cells from normal individuals responded to pokeweed mitogen with a 10-fold or greater increment in ig-secreting cells , cells from sarcoid patients failed to respond to pokeweed mitogen at any concentration employed ( p less than 0.001 , student 's t-test , two-tailed ) . | NA | {
"id": "C1321301",
"name": "peripheral blood mononuclear cells",
"pos": [
6,
40
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
155,
160
]
} |
the pooled hsp protein was applied to a cnbr-activated sepharose 4b column of bound 1c4 moab gamma globulin and the antibody bound fraction ( fr ) eluted was further purified by rechromatography in the same way . | NA | {
"id": "C0003250",
"name": "moab",
"pos": [
88,
92
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
116,
124
]
} |
these fractures were classified as type a at the stem tip , type b spiralling around the stem , and type c comminuted around the stem . | NA | {
"id": "C0016658",
"name": "fractures",
"pos": [
6,
15
]
} | {
"id": "C0476171",
"name": "comminuted",
"pos": [
107,
117
]
} |
since linoleic acid is readily converted to arachidonic acid , we assessed the effects of linoleic acid administration on immunoassayable pge and 6-oxo-pgf1 alpha excretion as indices of pge2 and pgi2 production . | NA | {
"id": "C0033559",
"name": "pge",
"pos": [
138,
141
]
} | {
"id": "C0012472",
"name": "pge2",
"pos": [
187,
191
]
} |
when re-examined after training the myoglobin level remained the same but creatine decreased significantly and the ratio between phosphocreatine and total creatine increased . | NA | {
"id": "C0031634",
"name": "phosphocreatine",
"pos": [
129,
144
]
} | {
"id": "C0010286",
"name": "creatine",
"pos": [
155,
163
]
} |
in contrast , when guar was ingested together with 25 g d-xylose , a non-metabolizable pentose , blood xylose levels were 25-40 % lower than when xylose was ingested alone ( p less than 0.01 ) . | NA | {
"id": "C0030894",
"name": "pentose",
"pos": [
87,
94
]
} | {
"id": "C0043375",
"name": "xylose",
"pos": [
146,
152
]
} |
analysis of the chondroitinase abc and ac digestion products of these gag indicated the presence of chondroitin-4 and -6 sulfates , and dermatan sulfate , but not heparan sulfate . | NA | {
"id": "C0008454",
"name": "chondroitin",
"pos": [
16,
27
]
} | {
"id": "C0011602",
"name": "dermatan sulfate",
"pos": [
136,
152
]
} |
therefore , it is proposed that the m1 protein be renamed ns analogous to vesicular stomatitis virus and that the m2 protein , being the only membrane protein , now be called simply the m protein . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
39,
46
]
} | {
"id": "C0025252",
"name": "membrane protein",
"pos": [
142,
158
]
} |
the major proteins of the viral suspension were the same proteins as those of the virion , except one glycoprotein ( mw 70,000 ) . | NA | {
"id": "C0042736",
"name": "proteins",
"pos": [
10,
18
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
57,
65
]
} |
three major dna repetition classes can be distinguished in the genomes of three hamster species mesocricetus auratus , cricetulus griseus , and phodopus sungorus sungorus : a very fast reassociating fraction of about 13 % of the dna , a fast reassociating fraction comprising 10-23 % of the dna , and a slowly reassociat... | NA | {
"id": "C0000702",
"name": "a",
"pos": [
7,
8
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
388,
391
]
} |
the accumulated choline was converted mainly into phosphorylcholine in 4-day hearts , while the percentage of conversion into acetylcholine increased in older embryos . | NA | {
"id": "C0008405",
"name": "choline",
"pos": [
16,
23
]
} | {
"id": "C0031716",
"name": "phosphorylcholine",
"pos": [
50,
67
]
} |
it is a large ( 170,000 daltons in the presence of triton x-100 ) , stable and acidic enzyme ( pi = 4.1 ) that has the electrophoretic mobility of a type zero or type 1 isoenzyme in acid ( ph 4.3 ) polyacrylamide gels . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
86,
92
]
} | {
"id": "C0022173",
"name": "isoenzyme",
"pos": [
169,
178
]
} |
the enzyme is inhibited by sodium fluoride , 2-mercaptoethanol and mumolar amounts of a number of polyanionic molybdenum and heavy metal complexes that include the following : [ c ( nh2 ) 3 ] 4 [ ( c3h7o3po3 ) 2mo5o15 ] x 3h2o , [ c ( nh2 ) 3 ] 2 [ ( c6h5 ) 2asmo4o15h ] x h2o , ( nh4 ) 4 [ simo12o40 ] x h2o and ( nh4 )... | NA | {
"id": "C0026402",
"name": "molybdenum",
"pos": [
110,
120
]
} | {
"id": "C0347988",
"name": "heavy metal",
"pos": [
125,
136
]
} |
an antibody developed to this catfish insulin allowed the identification of proinsulin , and insulin intermediates . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
76,
86
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
93,
100
]
} |
amino acid composition of the isolated insulin intermediates was similar to the calculated amino acid composition of proinsulin , as determined from the analyses of the separate a , b and c chains . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
39,
46
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
117,
127
]
} |
generally , different clones of the same strains did not differ in the g + c content of their main dna or their satellite dna . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
99,
102
]
} | {
"id": "C0012934",
"name": "satellite dna",
"pos": [
112,
125
]
} |
the g + c content of the main dna of the td and xd strains of a. proteus were the same ( 25.3 and 29.3 % respectively ) as were the g + c contents of the satellite dna ( 54.7 and 61.8 % respectively ) . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
30,
33
]
} | {
"id": "C0012934",
"name": "satellite dna",
"pos": [
154,
167
]
} |
the g + c contents of the main dna being 57.4 and 59.8 % respectively and those of the satellite dna being 23.5 and 28.4 % respectively . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
31,
34
]
} | {
"id": "C0012934",
"name": "satellite dna",
"pos": [
87,
100
]
} |
as a result of their importance in the food industry , much is known about lipid composition , chemistry , flavor , off-flavor development , and their technological implications in foods of dry , oil-rich seeds such as soybeans and peanuts . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
75,
80
]
} | {
"id": "C0028908",
"name": "oil",
"pos": [
196,
199
]
} |
other food legume lipids have not been studied in any great detail because of their low lipid content and limited or negligible use for oil purposes . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
18,
24
]
} | {
"id": "C0028908",
"name": "oil",
"pos": [
136,
139
]
} |
fifteen cell hybrids were obtained by fusing mim fibroblasts and an hprt- chinese hamster cell line . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
8,
12
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
49,
60
]
} |
the trial exercise test caused a decrease in fev1 in eia patients only , whereas measurements of sgaw revealed a significant but less pronounced postexercise bronchoconstriction in neia-patients as well . | NA | {
"id": "C0004099",
"name": "eia",
"pos": [
53,
56
]
} | {
"id": "C0004096",
"name": "neia",
"pos": [
181,
185
]
} |
this tubular resection has been used by us since 1981 in 11 patients ( 7 adenomas , 3 adenocarcinomas and one carcinoid ) . | NA | {
"id": "C0001418",
"name": "adenocarcinomas",
"pos": [
86,
101
]
} | {
"id": "C0007095",
"name": "carcinoid",
"pos": [
110,
119
]
} |
especially the injury to the retropatellar cartilage with following chondromalacia -- sometimes initiating the development of patellofemoral osteoarthritis -- renders the dislocation of the patella a severe injury of the knee region . | NA | {
"id": "C1135812",
"name": "the dislocation of",
"pos": [
167,
185
]
} | {
"id": "C0022744",
"name": "injury of",
"pos": [
207,
216
]
} |
silver stained proteins were sometimes observed in contact with the chromatin fibers , suggesting that at least some of the ag-nor proteins might be closely connected with the dispersed nucleolar dna . | NA | {
"id": "C0382507",
"name": "silver",
"pos": [
0,
6
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
131,
139
]
} |
however , clinical experience with zimelidine to date has been limited , and further well designed studies are required to define the role of the drug more clearly in treating depressive illness compared with other antidepressants , and particularly to define whether some types of depression may respond more readily to... | NA | {
"id": "C1579362",
"name": "other antidepressants",
"pos": [
209,
230
]
} | {
"id": "C0003289",
"name": "antidepressants",
"pos": [
346,
361
]
} |
patients were referred because of persisting doubt concerning either the diagnosis of epilepsy , or the type of epilepsy present in those with definite seizures . | NA | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
86,
94
]
} | {
"id": "C0036572",
"name": "seizures",
"pos": [
152,
160
]
} |
in control experiments the insulin secretion was nearly doubled when glucose was administered intraduodenally , as compared to an iv glucose load to simulate the blood glucose curve after the intraduodenal glucose administration . | NA | {
"id": "C0017725",
"name": "glucose",
"pos": [
69,
76
]
} | {
"id": "C0005802",
"name": "blood glucose",
"pos": [
162,
175
]
} |
the principal side effects of the drug carbenoxolone ( biogastrone ; 18 beta-glycyrrhetinic acid sodium hemisuccinate ) are sodium retention , hypokalemic alkalosis , suppressed plasma renin , and hypertension . | NA | {
"id": "C0006979",
"name": "carbenoxolone",
"pos": [
39,
52
]
} | {
"id": "C0017986",
"name": "18",
"pos": [
69,
71
]
} |
we have compared the metabolism of infused somatostatin 14 ( ss14 ) and somatostatin 28 ( ss 28 ) in anesthetized dogs . | NA | {
"id": "C0037659",
"name": "somatostatin 14",
"pos": [
43,
58
]
} | {
"id": "C0074854",
"name": "somatostatin 28",
"pos": [
72,
87
]
} |
the transfer of chemically synthesized genes for human insulin a and b chains as well as the naturally occurring rat insulin gene into bacteria opened possibilities to produce insulin in bacterial systems . | NA | {
"id": "C0795635",
"name": "human insulin",
"pos": [
49,
62
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
176,
183
]
} |
structural analysis of human insulin genes isolated from a human chromosomal gene library led to the identification of allelic variants of a single human insulin gene . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
29,
36
]
} | {
"id": "C0795635",
"name": "human insulin",
"pos": [
148,
161
]
} |
this `` '' normocalcemic biochemical hyperparathyroidism '' '' was complicated with hyperkalemia due to aldosterone suppression , a counterpart of the recently described association with hypokalemia due to primary hyperaldosteronism , necessitating further studies on the occurrence and significance of altered productio... | NA | {
"id": "C0020502",
"name": "hyperparathyroidis",
"pos": [
37,
55
]
} | {
"id": "C0221002",
"name": "primary hyperparathyroidi",
"pos": [
364,
389
]
} |
ovariectomy evoked an increase in total lipid and phospholipid concentration , has no effect on glycerides and lowered total cholesterol concentration in rat adrenals , while estradiol replacement diminished concentration of all classes of lipids studied . | NA | {
"id": "C0017860",
"name": "glycerides",
"pos": [
96,
106
]
} | {
"id": "C0023779",
"name": "lipids",
"pos": [
240,
246
]
} |
peak levels of norepinephrine ( 228.9 +/- 36.0 ng/l ) and epinephrine ( 720.6 +/- 125.6 ng/l ) are observed at 30 and 45 min , those of camp ( 33.4 +/- 2.5 pmol/ml ) , glucagon ( 0.209 +/- 0.024 ng/ml ) , acth ( 166.0 +/- 40.1 ng/ml ) , and prolactin ( 28.1 +/- 7.8 ng/ml ) at 45 min and finally those of cortisol ( 26.1... | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
15,
29
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
58,
69
]
} |
the use of 13c-nmr spectroscopy in the establishment of lipid a backbone structure from lipopolysaccharide of yersinia pseudotuberculosis has been described . | NA | {
"id": "C0023767",
"name": "lipid a",
"pos": [
56,
63
]
} | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
88,
106
]
} |
it was shown that lipid a backbone of the lipopolysaccharide in question consists of beta-1,6-linked glucosamine disaccharide . | NA | {
"id": "C0023767",
"name": "lipid a",
"pos": [
18,
25
]
} | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
42,
60
]
} |
only peptides with a free n-terminal amino group and proline , hydroxyproline , or alanine in position 2 of the n-terminal sequence are cleaved . | NA | {
"id": "C0033382",
"name": "proline",
"pos": [
53,
60
]
} | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
63,
77
]
} |
however , in strains lacking phosphofructokinase 1 , a high level of phosphofructokinase 2 is associated with unusually high concentrations of hexose monophosphates during growth on glucose , while a strain with phosphofructokinase 2* instead of phosphofructokinase 2 grows more rapidly on glucose and contains lower lev... | NA | {
"id": "C0017725",
"name": "glucose",
"pos": [
182,
189
]
} | {
"id": "C0019494",
"name": "hexose",
"pos": [
327,
333
]
} |
in gluconeogenic conditions , by contrast , hexose monophosphate levels are normal in phosphofructokinase 2 strains , while the impaired growth of phosphofructokinase 2* strains is associated with high levels of fructose 2,6-bisphosphate and very low levels of hexose monophosphates . | NA | {
"id": "C0016745",
"name": "fructose",
"pos": [
212,
220
]
} | {
"id": "C0019494",
"name": "hexose",
"pos": [
261,
267
]
} |
the three main fractions of clupeine , the protamine extracted from herring sperm , have been investigated by 13c nuclear magnetic resonance techniques . | NA | {
"id": "C0009083",
"name": "clupeine",
"pos": [
28,
36
]
} | {
"id": "C0033603",
"name": "protamine",
"pos": [
43,
52
]
} |
analysis by sds-polyacrylamide gel electrophoresis of pulse-labelled plasmodial proteins reveals that blue light inhibits the synthesis of distinct starvation-induced proteins and allows continued synthesis of all major plasmodial proteins . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
80,
88
]
} | {
"id": "C0034861",
"name": "synthesis",
"pos": [
197,
206
]
} |
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