text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
no reduction in the hydrogenase activity is observed when the enzyme is assayed directly by the tritium exchange method , indicating that the decrease in hydrogen uptake activity is not due to repression of hydrogenase biosynthesis . | NA | {
"id": "C0041119",
"name": "tritium",
"pos": [
96,
103
]
} | {
"id": "C0020275",
"name": "hydrogen",
"pos": [
207,
215
]
} |
the polycation , poly ( l-lysine ) , repressed the synthesis of glycosaminoglycans in secondary cultures of chick embryo skin fibroblasts and caused sequestration of glycosaminoglycans around the cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
126,
137
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
196,
201
]
} |
neutral lipids , unsaturated lipids , phospholipids and fatty acids are demonstrated in yolk bodies and lipoproteins , unsaturated lipids and fatty acids constitute part of the egg envelopes . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
104,
116
]
} | {
"id": "C0023779",
"name": "lipids",
"pos": [
131,
137
]
} |
the data obtained on the protease formation during growth and sporulation and the level of their activity are indicative of intracellular proteases involvement in spore- and crystal formation . | NA | {
"id": "C0030946",
"name": "protease",
"pos": [
25,
33
]
} | {
"id": "C0030940",
"name": "proteases",
"pos": [
138,
147
]
} |
the tissue-specific differences in the 5-methylcytosine ( m5c ) content in total dna of the parasite plant cuscuta reflexa have been found : dna from apical parts of the plant is less methylated ( m5c = 4,2 mol % ) as compared to the dna from haustoria and posthaustorial regions ( m5c = 5,4 mol % ) . | NA | {
"id": "C0242964",
"name": "dna",
"pos": [
81,
84
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
234,
237
]
} |
the m5c amount in stem dna of the alfalfa plant infected with c. reflexa is by approximately 25 % higher than that in the non-infected plant dna . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
23,
26
]
} | {
"id": "C0242964",
"name": "plant dna",
"pos": [
135,
144
]
} |
the amino acid composition of this enzyme is different from that of other subtilisins , e. g. subtilisin carlsberg . | NA | {
"id": "C0038601",
"name": "subtilisins",
"pos": [
74,
85
]
} | {
"id": "C0038597",
"name": "subtilisin carlsberg",
"pos": [
94,
114
]
} |
the effects of alpha-tocopherol and its derivatives ( alpha-tocopherylquinone , its short-chained analog -- alpha-tocopheronolactone -- and short-chained alpha-tocopherylacetate ) on the levels of ubiquinone , its cyclic isomer -- ubichromenol -- and vitamin e in the liver and heart of vitamin e-deficient rats were stu... | NA | {
"id": "C0078373",
"name": "tocopherylacetate",
"pos": [
160,
177
]
} | {
"id": "C0042874",
"name": "vitamin e",
"pos": [
287,
296
]
} |
with insoluble cellulose , maximum enzyme production and activities were obtained using an alkali-treated cellulose powder . | NA | {
"id": "C0007648",
"name": "cellulose",
"pos": [
15,
24
]
} | {
"id": "C0789987",
"name": "cellulose powder",
"pos": [
106,
122
]
} |
antibodies on sepharose immunosorbents containing a-polysaccharide-sepharose or synthetic beta-n-acetylglucosamine , were isolated from the sera of rabbits immunized with streptococci , group a , by means of affinity chromatography . | NA | {
"id": "C0032594",
"name": "polysaccharide",
"pos": [
52,
66
]
} | {
"id": "C0036681",
"name": "sepharose",
"pos": [
67,
76
]
} |
further studies in the responsive patient indicated that ( 1 ) colony growth was enhanced by depleting t lymphocytes from the marrow cells , ( 2 ) colon growth t-depleted marrow cells was inhibited by autologous peripheral blood lymphocytes ( pbl ) , ( 3 ) cortisol failed to enhance colony growth of t-depleted marrow c... | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
133,
138
]
} | {
"id": "C3485979",
"name": "allogeneic",
"pos": [
411,
421
]
} |
immunoelectrophoretic analysis of partially purified thrombopoietin indicated that following removal of most of the albumin by deae chromatography , only proteins with the mobilities of beta-globulins and albumin and traces of other anodally migrating proteins were detectable in the fractions that contained thrombopoie... | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
116,
123
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
252,
260
]
} |
it is shown that myelocytes in chronic phase cml are resistant , but blast cells from both clinical stages as well as maturational defective myelocytes from blastic crisis cml are highly sensitive to these antimetabolites . | NA | {
"id": "C0023474",
"name": "chronic phase cml",
"pos": [
31,
48
]
} | {
"id": "C0023473",
"name": "cml",
"pos": [
172,
175
]
} |
since the malignant cells from patients with several other forms of leukemia and the peripheral blood mononuclear cells from healthy individuals did not show a comparable degree of responsiveness to lps , we could exclude the possibility that this response was due to effects on contaminating normal mononuclear cells or... | NA | {
"id": "C0007634",
"name": "the",
"pos": [
6,
9
]
} | {
"id": "C1321301",
"name": "peripheral",
"pos": [
85,
95
]
} |
4 the results obtained in the iris show the existence of an acetylcholine receptor population similar to the nicotinic receptor of the skeletal muscle . | NA | {
"id": "C0034792",
"name": "acetylcholine receptor",
"pos": [
60,
82
]
} | {
"id": "C0034830",
"name": "nicotinic receptor",
"pos": [
109,
127
]
} |
responses of the hepatic arterial and portal venous vascular beds of the dog to intra-arterial infusions of noradrenaline and adrenaline : inhibition of the hepatic arterial vasoconstrictor responses by intraportal infusions of glucagon [ proceedings ] . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
108,
121
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
126,
136
]
} |
synthesis of catecholamines as measured by dopa accumulation in monkeys treated with an aromatic amino acid decarboxylase inhibitor , nsd 1015 , generally parallels the distribution of the catecholamines while indoleamine synthesis , as measured by 5-htp accumulation , is similar to the distribution of 5-hydroxyindolea... | NA | {
"id": "C0013023",
"name": "dopa",
"pos": [
43,
47
]
} | {
"id": "C0007412",
"name": "catecholamines",
"pos": [
189,
203
]
} |
the glycoproteins of isolated synaptic junctions which bind the plant lectin concanavalin a ( con a ) were also examined . | NA | {
"id": "C0304052",
"name": "plant lectin",
"pos": [
64,
76
]
} | {
"id": "C0009630",
"name": "concanavalin a",
"pos": [
77,
91
]
} |
purification and some properties of five endo-1,4-beta-d-xylanases and a beta-d-xylosidase produced by a strain of aspergillus niger . | NA | {
"id": "C0059100",
"name": "xylanases",
"pos": [
57,
66
]
} | {
"id": "C0043376",
"name": "xylosidase",
"pos": [
80,
90
]
} |
five different xylanases and a beta-d-xylosidase in the culture medium of aspergillus niger have been purified to homogeneity from 13- to 52-fold by a procedure of gel and hydroxylapatite chromatography . | NA | {
"id": "C0059100",
"name": "xylanases",
"pos": [
15,
24
]
} | {
"id": "C0043376",
"name": "xylosidase",
"pos": [
38,
48
]
} |
two xylanases showed relatively broad substrate specificity and were able to degrade also crystalline cellulose . beta-d-xylosidase showed optimal activity at ph 6.7 to 7.0 and at 42 degrees c . | NA | {
"id": "C0059100",
"name": "xylanases",
"pos": [
4,
13
]
} | {
"id": "C0043376",
"name": "xylosidase",
"pos": [
121,
131
]
} |
in order to establish if bradykinin ( bk ) and lys-bradykinin ( lys-bk ) , alias kallidin , act on the same or on different receptors , experiments were performed on strips of cat terminal ileum and of rabbit aorta . | NA | {
"id": "C0006100",
"name": "bradykinin",
"pos": [
25,
35
]
} | {
"id": "C0022474",
"name": "kallidin",
"pos": [
81,
89
]
} |
the criterion used for establishing the identity of receptors for bk and lys-bk in the cat ileum ( receptor b2 ) was desensitization , while for the rabbit aorta ( receptor b1 ) we measured the apparent affinity ( pa2 value ) of a competitive and specific inhibitor of bk , [ leu-ome3 , des-arg9 ] -bk . | NA | {
"id": "C0022474",
"name": "lys-bk",
"pos": [
73,
79
]
} | {
"id": "C0006100",
"name": "bk",
"pos": [
299,
301
]
} |
since cat ileum desensitized with bk or lys-bk shows a significant decrease or a complete disappearance of the response to the other agent , while maintaining full sensitivity for histamine , and since the pa2 values of [ leu-ome8 , des-arg9 ] -bk against bk and lys-bk are identical in the rabbit aorta , we conclude th... | NA | {
"id": "C0006100",
"name": "bk",
"pos": [
34,
36
]
} | {
"id": "C0022474",
"name": "lys-bk",
"pos": [
263,
269
]
} |
since cat ileum desensitized with bk or lys-bk shows a significant decrease or a complete disappearance of the response to the other agent , while maintaining full sensitivity for histamine , and since the pa2 values of [ leu-ome8 , des-arg9 ] -bk against bk and lys-bk are identical in the rabbit aorta , we conclude th... | NA | {
"id": "C0006100",
"name": "bk",
"pos": [
34,
36
]
} | {
"id": "C0022714",
"name": "kinins",
"pos": [
331,
337
]
} |
a peroxide-resistant mutant ( pr ) was isolated from proteus mirabilis using the hydrogen peroxide mutagenic property . | NA | {
"id": "C0031180",
"name": "peroxide",
"pos": [
2,
10
]
} | {
"id": "C0020281",
"name": "hydrogen peroxide",
"pos": [
81,
98
]
} |
when pr bacteria were subjected to high doses of h2o2 ( 150mm ) , the determination of catalasic activity in vivo increased ; | NA | {
"id": "C0031180",
"name": "pr",
"pos": [
5,
7
]
} | {
"id": "C0020281",
"name": "h2o2",
"pos": [
49,
53
]
} |
the behavior of a membrane enzyme ( l-phenylalanine oxidase ) of the pr mutant shows that h2o2 may cause lesions way up to the internal membrane of bacteria . | NA | {
"id": "C0031180",
"name": "pr",
"pos": [
69,
71
]
} | {
"id": "C0020281",
"name": "h2o2",
"pos": [
90,
94
]
} |
these effects resemble those obtained with two other mycotoxins which possess a lactone structure : aflatoxin b1 and patulin . | NA | {
"id": "C0026955",
"name": "mycotoxins",
"pos": [
53,
63
]
} | {
"id": "C0030710",
"name": "patulin",
"pos": [
117,
124
]
} |
the authors identified and classified these fractures according to the amount of instability , comminution , angulation , displacement , rotational deformity and ankle joint involvement . | NA | {
"id": "C0016658",
"name": "fractures",
"pos": [
44,
53
]
} | {
"id": "C0476171",
"name": "comminution",
"pos": [
95,
106
]
} |
type 3 and 4 fractures ( unstable , comminuted , with angulation greater than 15 degrees , displacement and rotational deformity ) sometimes resulted in osteoarthritis of the ankle joint . | NA | {
"id": "C0016658",
"name": "fractures",
"pos": [
13,
22
]
} | {
"id": "C0476171",
"name": "comminuted",
"pos": [
36,
46
]
} |
with three exceptions the findings compared well : at chul ( a ) the frequency of the hla-b27 antigen in patients with axial psoriatic arthritis was very low , ( b ) patients with synchronous psoriasis and arthritis were not more severely affected , and ( c ) certain radiologic signs that seem to be rare and have proba... | NA | {
"id": "C0003872",
"name": "psoriatic arthritis",
"pos": [
125,
144
]
} | {
"id": "C0033860",
"name": "psoriasis",
"pos": [
192,
201
]
} |
various abdominal x-ray examinations revealed nonspecific abnormalities ( ileus , bowel obstruction , abdominal mass ) in about half the cases in which they were obtained , but in only one instance was the correct diagnosis of small bowel tumor made preoperatively . | NA | {
"id": "C1258215",
"name": "ileus",
"pos": [
74,
79
]
} | {
"id": "C0021843",
"name": "bowel obstruction",
"pos": [
82,
99
]
} |
evidence for antigenic distinctness of the epstein -- barr virus-determined nuclear antigen and the herpesvirus papio-determined nuclear antigen . | NA | {
"id": "C0003320",
"name": "antigenic",
"pos": [
13,
22
]
} | {
"id": "C0069115",
"name": "nuclear antigen",
"pos": [
129,
144
]
} |
evidence for antigenic distinctness of the epstein -- barr virus-determined nuclear antigen and the herpesvirus papio-determined nuclear antigen . | NA | {
"id": "C0116397",
"name": "epstein",
"pos": [
43,
50
]
} | {
"id": "C0069115",
"name": "nuclear antigen",
"pos": [
129,
144
]
} |
previous serological evidence indicated that epstein -- barr virus-determined nuclear antigen ( ebna ) has cross reactive components with the herpesvirus papio-determined nuclear antigen ( hupna ) and , in addition , it has distinct components of its own , not present in hupna . | NA | {
"id": "C0116397",
"name": "epstein",
"pos": [
45,
52
]
} | {
"id": "C0069115",
"name": "hupna",
"pos": [
272,
277
]
} |
reported previously in certain human carcinomas and rat and mouse experimental tumor systems , circulating immune complexes ( ic ) have now been detected in syrian hamsters bearing tumors produced by injection with syngeneic tsv5cl2 cells . | NA | {
"id": "C0027659",
"name": "experimental",
"pos": [
66,
78
]
} | {
"id": "C0027651",
"name": "tumors",
"pos": [
181,
187
]
} |
the addition of 1 mm adenosine to the myocardial cell cultures markedly increased the adenosine triphosphate concentration but not the adenylate charge . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
21,
30
]
} | {
"id": "C0001480",
"name": "adenosine",
"pos": [
86,
95
]
} |
in the adm-treated cells , the addition of adenosine increased both the adenosine triphosphate concentration and the adenylate charge , and , concomitant with this increase , the functional integrity of the cells in terms of percentage of beating cells and rate of contractions was maintained . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
43,
52
]
} | {
"id": "C0001480",
"name": "adenosine triphosphate",
"pos": [
72,
94
]
} |
the carcinogen 4-nitroquinoline 1-oxide ( 4-nqo ) was found to rapidly deplete non-protein thiols ( npsh ) from ehrlich ascites tumor cells and v79 chinese hamster fibroblasts . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
134,
139
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
164,
175
]
} |
greater thiol loss under oxic than under hypoxic conditions suggested oxidation by superoxide , peroxide , or hydroxyl radical formed in the course of 4-nqo reduction . | NA | {
"id": "C0038836",
"name": "superoxide",
"pos": [
83,
93
]
} | {
"id": "C0031180",
"name": "peroxide",
"pos": [
96,
104
]
} |
furthermore , even a nine-week delay in starting the retinoid feeding did not diminish the ability of 13-cis-retinoic acid to inhibit bladder carcinogenesis . | NA | {
"id": "C0035339",
"name": "retinoid",
"pos": [
53,
61
]
} | {
"id": "C0022265",
"name": "13-cis-retinoic",
"pos": [
102,
117
]
} |
the chemotherapeutic effects of 6-diazo-5-oxo-l-norleucine ( don ) and n- [ n-gamma-glutamyl-6-diazo-5-oxo-norleucinyl ] 6-diazo-5-oxo-norleucine ( azotomycin ) were evaluated in a spectrum of transplantable experimental tumor systems including xenografts of human tumors in athymic mice . | NA | {
"id": "C0027659",
"name": "experimental tumor",
"pos": [
208,
226
]
} | {
"id": "C0027651",
"name": "tumors",
"pos": [
265,
271
]
} |
no significant activity was observed against lewis lung carcinoma , b16 carcinoma , b16 melanoma , and intracranial ependymoblastoma . | NA | {
"id": "C0243038",
"name": "lewis lung carcinoma",
"pos": [
45,
65
]
} | {
"id": "C0007097",
"name": "carcinoma",
"pos": [
72,
81
]
} |
the location , cytology and projections of vasopressin- , oxytocin- , and neurophysin-producing neurons in the guinea pig were investigated using specific antisera against vasopressin , oxytocin or neurophysin in the unlabeled antibody enzyme immunoperoxidase method . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
155,
163
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
227,
235
]
} |
using an antiserum to porcine acth and the unlabeled antibody preoxidase-antiperoxidase technique , we have found that acth is present in neuronal cell bodies located exclusively in the arcuate nucleus of the human hypothalamus . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
9,
18
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
53,
61
]
} |
the average number and numerical distribution of sites per fibroblast cell are not affected by time of exposure to colcemid or the concentration of colcemid applied to the cells . | NA | {
"id": "C0016030",
"name": "fibroblast cell",
"pos": [
59,
74
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
172,
177
]
} |
pretreatment of fibroblasts with bacterial collagenase , chondroitinase abc or testicular hyaluronidase does not affect the binding reaction , whereas pretreatment of the cells with phospholipase c increases the amount of ligand bound . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
16,
27
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
171,
176
]
} |
in the course of characterizing the closed circular dna , we observed two form i dna molecules . | NA | {
"id": "C0012925",
"name": "circular dna",
"pos": [
43,
55
]
} | {
"id": "C0012854",
"name": "dna molecules",
"pos": [
81,
94
]
} |
using the restriction endonuclease maps which we derived , we demonstrate that this novel form i dna is a smaller homogeneous species of viral dna , missing about 600 nucleotides found in the linear and larger closed circular dna molecules . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
97,
100
]
} | {
"id": "C0012939",
"name": "viral dna",
"pos": [
137,
146
]
} |
using the restriction endonuclease maps which we derived , we demonstrate that this novel form i dna is a smaller homogeneous species of viral dna , missing about 600 nucleotides found in the linear and larger closed circular dna molecules . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
97,
100
]
} | {
"id": "C0012925",
"name": "circular dna",
"pos": [
217,
229
]
} |
we have localized the site of this missing dna piece to be at either one or both ends of the linear viral dna . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
43,
46
]
} | {
"id": "C0012939",
"name": "viral dna",
"pos": [
100,
109
]
} |
each structure had an individual combination of n1 and n2 nucleotides , where n1 was always a purine nucleotide but n2 was any nucleotide subject to the single exception that m7gpppgmpcp is found only in low yield . | NA | {
"id": "C0034137",
"name": "purine nucleotide",
"pos": [
94,
111
]
} | {
"id": "C0028630",
"name": "nucleotide",
"pos": [
127,
137
]
} |
seven of them have deletions located entirely within the hae iii subfragment a of hpa ii-4 ( the hae a subfragment , 78.4 -- 85.2 map units ) , and one extends just beyond this subfragment , ending at 85.5 map units . | NA | {
"id": "C1857728",
"name": "hae iii",
"pos": [
57,
64
]
} | {
"id": "C0019243",
"name": "hae",
"pos": [
97,
100
]
} |
the complete dna sequence of the leader region has been determined and does not contain the initiation codon aug , although this codon does occur immediately downstream from the junction between the fourth leader and the main body of the fiber mrna . | NA | {
"id": "C0242610",
"name": "initiation codon",
"pos": [
92,
108
]
} | {
"id": "C0009221",
"name": "codon",
"pos": [
129,
134
]
} |
it is longer than the viral rna at both ends , evidently due to repetitive copying of segments of the rna . | NA | {
"id": "C0035736",
"name": "viral rna",
"pos": [
22,
31
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
102,
105
]
} |
virions also synthesize an 8.4 kbp double-stranded circular dna that lacks one copy of the terminal repetition , as well as viral dna longer than 9 kbp . | NA | {
"id": "C0012854",
"name": "double-stranded",
"pos": [
35,
50
]
} | {
"id": "C0012939",
"name": "viral dna",
"pos": [
124,
133
]
} |
the transformed cells also secrete phosphoproteins in the same size range , but these are immunologically distinct from the 58k proteins mentioned above . | NA | {
"id": "C0031689",
"name": "phosphoproteins",
"pos": [
35,
50
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
128,
136
]
} |
all three properties ( 58k protein , phosphoprotein , in vitro phosphorylation ) are closely correlated with transformation in cells transformed by temperature-sensitive viruses . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
27,
34
]
} | {
"id": "C0031689",
"name": "phosphoprotein",
"pos": [
37,
51
]
} |
after three or more passages , stromal cell outgrowths from explants of normal rabbit corneas and from corneas previously burned with alkali did not produce collagenase until they were stimulated by the addition of rabbit blood-derived mononuclear cells or media conditioned by them . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
39,
43
]
} | {
"id": "C1321301",
"name": "blood",
"pos": [
222,
227
]
} |
similar results were obtained with bovine fibroblasts , indicating that a dynamic equilibrium exists between hmg1 and chromatin within living cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
42,
53
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
142,
147
]
} |
autoradiographic analysis of cells fixed over a period of several days after injection produced apparent half-lives for 125i-hmg1 of 80 hr in hela cells and 100 hr in bovine fibroblasts . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
29,
34
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
174,
185
]
} |
experiments were carried out to test the hypothesis that the initial attachment and spreading of human fibroblasts in serum-free medium occurs to cell fibronectin which has been secretd spread on tissue culture substrata in serum-free medium in 60 min . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
103,
114
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
146,
150
]
} |
concomitant with human fibroblast spreading , the random distribution of sites disappeared , and most fibronectin was subsequently observed in spots at the cell substratum interface ( 60 min ) . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
23,
33
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
156,
160
]
} |
the sites beneath the cells could be visualized as footprints on the substratum following treatment of the attached human fibroblasts with 0.1 m naoh . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
0,
3
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
122,
133
]
} |
another cell type ( baby hamster kideny cells ) was used to assay biologically for the presence or absence of the factor secreted by human fibroblasts on the substratum . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
40,
45
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
139,
150
]
} |
following pma treatment of serum-free rsvcef cultures , pa induction is accompanied by distinct morphological changes , including enhanced cell clustering and the formation of dense cellular aggregates . | NA | {
"id": "C0016030",
"name": "rsvcef",
"pos": [
38,
44
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
182,
186
]
} |
the two populations of particles contained acid hydrolases ( phosphatase , six glycosidases and four cathepsins ) in roughly equal proportions , displayed latency , had similar turnover of 35s-mucopolysaccharide in normal as well as in iduronidase-deficient cells , and were recipients of alpha-l-iduronidase , previousl... | NA | {
"id": "C0020289",
"name": "hydrolases",
"pos": [
48,
58
]
} | {
"id": "C0017976",
"name": "glycosidases",
"pos": [
79,
91
]
} |
the two populations of particles contained acid hydrolases ( phosphatase , six glycosidases and four cathepsins ) in roughly equal proportions , displayed latency , had similar turnover of 35s-mucopolysaccharide in normal as well as in iduronidase-deficient cells , and were recipients of alpha-l-iduronidase , previousl... | NA | {
"id": "C0017976",
"name": "glycosidases",
"pos": [
79,
91
]
} | {
"id": "C0020818",
"name": "alpha-l-iduronidase",
"pos": [
289,
308
]
} |
gyrase made a staggered cut , creating dna termini with a free 3 ' hydroxyl and a 5 ' extension that provided a template primer for dna polymerase . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
39,
42
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
143,
144
]
} |
the nucleotide sequences have been determined for the promoter regions of two ribosomal rna operons , rrna and rrne , in e. coli . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
88,
91
]
} | {
"id": "C0035701",
"name": "rrna",
"pos": [
102,
106
]
} |
reconstituted dna-hu complexes prefixed with glutaraldehyde appear as condensed circular structures having an average of 14 `` '' beads '' '' per circular sv40 dna molecule , with a `` '' bead '' '' diameter of 180 +/- 23 a . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
14,
17
]
} | {
"id": "C0012925",
"name": "circul",
"pos": [
80,
86
]
} |
the circular sv40 dna is condensed by a ratio of 2.0-2.5 relative to naked dna . | NA | {
"id": "C0012925",
"name": "circular",
"pos": [
4,
12
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
75,
78
]
} |
surface proteins of chick myotubes and 'mature ' unfused myoblasts ( myoblasts grown for 7 days in a calcium-depleted medium ) were found to bind an equal amount of probe , which is twice the amount bound by surface proteins in 'immature ' myoblasts ( 1 -- 2 days of culture ) and fibroblasts . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
8,
16
]
} | {
"id": "C0025252",
"name": "surface proteins",
"pos": [
208,
224
]
} |
in contrast , analysis of staining patterns after electrophoresis in sodium dodecyl sulphate containing gels revealed a striking similarity between normal proteins , tumour proteins and proteins obtained from metastatic growths . | NA | {
"id": "C0027642",
"name": "tumour proteins",
"pos": [
166,
181
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
186,
194
]
} |
it thus appears that tumour proteins closely resemble the normal proteins from the tissue of origin with respect to molecular size as determined by electrophoretic mobility , while significant differences occur in charge and labelling kinetics . | NA | {
"id": "C0027642",
"name": "tumour proteins",
"pos": [
21,
36
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
65,
73
]
} |
furthermore , this extracellular factor inhibits the ribosomal rna synthesis in vitro when added to an rna synthesizing r-chromatin preparation . | NA | {
"id": "C0035701",
"name": "ribosomal rna",
"pos": [
53,
66
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
103,
106
]
} |
the sv40-specific rna molecules migrate on sucrose gradients as do viral rnas formed in infected green monkey cells but a variable proportion of rna sequences complementary to sv40 dna is also found in the light region of the gradients . | NA | {
"id": "C0035736",
"name": "viral rnas",
"pos": [
67,
77
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
145,
148
]
} |
besides ethanol , other aliphatic alcohols such as n-propanol and isopropanol induce a triacylglycerol ( tag ) accumulation in the liver . | NA | {
"id": "C0001962",
"name": "ethanol",
"pos": [
8,
15
]
} | {
"id": "C0022237",
"name": "isopropanol",
"pos": [
66,
77
]
} |
in contrast to ethanol and n-propanol which , at the dose presently used , increase precursor incorporation into blood tag , isopropanol inhibits this incorporation . | NA | {
"id": "C0001962",
"name": "ethanol",
"pos": [
15,
22
]
} | {
"id": "C0022237",
"name": "isopropanol",
"pos": [
125,
136
]
} |
interference with the process of very low density lipoprotein ( vldl ) synthesis and/or secretion , which appears only at a late stage of isopropanol intoxication , is probably responsible for the intensity and duration of the fatty liver observed after administration of this alcohol . | NA | {
"id": "C0022237",
"name": "isopropanol",
"pos": [
138,
149
]
} | {
"id": "C0001962",
"name": "alcohol",
"pos": [
277,
284
]
} |
a small increase in the liver content of oxidized glutathione could not account for the decrease content of gsh . | NA | {
"id": "C0061516",
"name": "oxidized glutathione",
"pos": [
41,
61
]
} | {
"id": "C0017817",
"name": "gsh",
"pos": [
108,
111
]
} |
major objective responses ( complete and partial remissions ) were seen in bronchogenic carcinomas , melanoma , testicular carcinoma , esophageal carcinoma , acute lymphocytic leukemia , malignant lymphoma ( hodgkin 's and non-hodgkin 's ) and wilms ' tumor . | NA | {
"id": "C0024299",
"name": "malignant lymphoma",
"pos": [
187,
205
]
} | {
"id": "C0024305",
"name": "non-hodgkin 's",
"pos": [
223,
237
]
} |
the t-lymphocyte depleted sheep demonstrated markedly obtunded increases in pulmonary arterial pressure and pulmonary vascular resistance following endotoxin when compared to the effects of the lipopolysaccharide in control animals . additionally , the lymphocyte depleted group showed a significant augmentation of myoc... | NA | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
148,
157
]
} | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
194,
212
]
} |
we developed a radioimmunoassay with the antiserum obtained , in which we used polyethylene glycol in conjunction with a second precipitating antibody for fast ( 15-min ) separation of antibody-bound and free corticotropin . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
41,
50
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
185,
193
]
} |
steady-state concentrations of diazepam and nordiazepam in serum as determined by gas-liquid chromatography correlated closely with those found by liquid-liquid chromatography . | NA | {
"id": "C0012010",
"name": "diazepam",
"pos": [
31,
39
]
} | {
"id": "C0011279",
"name": "nordiazepam",
"pos": [
44,
55
]
} |
urinary excretion of thymine and uracil in a two-year-old child with a malignant tumor of the brain . | NA | {
"id": "C0040087",
"name": "thymine",
"pos": [
21,
28
]
} | {
"id": "C0041917",
"name": "uracil",
"pos": [
33,
39
]
} |
a two-year-old boy with a malignant tumor of the brain ( medulloblastoma ) excreted large amounts of thymine and uracil in his urine . | NA | {
"id": "C0040087",
"name": "thymine",
"pos": [
101,
108
]
} | {
"id": "C0041917",
"name": "uracil",
"pos": [
113,
119
]
} |
the excretion was related to progress and regress of the disease , and reached a maximum of 3.0 mol of thymine per mole of creatinine and 2.6 mol of uracil per mole of creatinine . | NA | {
"id": "C0040087",
"name": "thymine",
"pos": [
103,
110
]
} | {
"id": "C0041917",
"name": "uracil",
"pos": [
149,
155
]
} |
improved determination of phenobarbital , primidone , and phenytoin by use of a preparative instrument for extraction , followed by gas chromatography . | NA | {
"id": "C0031412",
"name": "phenobarbital",
"pos": [
26,
39
]
} | {
"id": "C0033148",
"name": "primidone",
"pos": [
42,
51
]
} |
this instrument has been successfully evaluated for the extraction of phenobarbital , primidone , and phenytoin from human serum before chromatographic analysis . | NA | {
"id": "C0031412",
"name": "phenobarbital",
"pos": [
70,
83
]
} | {
"id": "C0033148",
"name": "primidone",
"pos": [
86,
95
]
} |
comparison of this method with results obtained with a liquid -- liquid micro-scale extraction and a similar gas-chromatographic method resulted in correlation coefficients of 0.988 ( phenobarbital ) , 0.978 ( primidone ) , and 0.982 ( phenytoin ) . | NA | {
"id": "C0031412",
"name": "phenobarbital",
"pos": [
184,
197
]
} | {
"id": "C0033148",
"name": "primidone",
"pos": [
210,
219
]
} |
the inter- and intra-individual components of variation in the saliva/blood alcohol ratio have been calculated from experiments with 48 male subjects after they drank 0.72 g of ethanol per kilogram of body weight as neat whisky after a short fast . | NA | {
"id": "C0001962",
"name": "ethanol",
"pos": [
177,
184
]
} | {
"id": "C0475610",
"name": "whisky",
"pos": [
221,
227
]
} |
we also found a significant correlation between the relative amounts of fatty acids in cholesteryl esters and phosphatidylcholine for all unsaturated fatty acids and for palmitate in all groups of subjects . | NA | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
72,
83
]
} | {
"id": "C0015690",
"name": "unsaturated fatty acids",
"pos": [
138,
161
]
} |
both antisera , however , appeared to be mixtures of antibodies , displaying different equivalences for activation , inactivation , and , possibly , precipitation . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
5,
13
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
53,
63
]
} |
both antisera cross reacted with mb and displayed antibodies that appeared to block only half of the activity as well as antibodies that blocked all of the activity . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
5,
13
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
121,
131
]
} |
we conclude that in diabetic patients presenting with hemoglobin s or hemoglobin c , there is a considerable decrease in the values for glycosylated hemoglobin as measured by cation-exchange chromatographic methods , and that this decrease is proportional to the percentage of the abnormal hemoglobin . | NA | {
"id": "C0019020",
"name": "hemoglobin c",
"pos": [
70,
82
]
} | {
"id": "C0019047",
"name": "abnormal",
"pos": [
281,
289
]
} |
effect of the angiotensin ii antagonist saralasin on plasma aldosterone concentration and on blood pressure before and during sodium depletion in normal subjects . | NA | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
14,
28
]
} | {
"id": "C0036193",
"name": "saralasin",
"pos": [
40,
49
]
} |
the effect of the angiotensin ii antagonist saralasin on plasma aldosterone , plasma angiotensin ii and blood pressure was studied in six normal supine subjects both before and during sodium depletion . | NA | {
"id": "C0036193",
"name": "saralasin",
"pos": [
44,
53
]
} | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
85,
99
]
} |
during sodium depletion , infusion of the angiotensin antagonist caused a fall in plasma aldosterone and an increase in plasma angiotensin ii in each subject . | NA | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
42,
53
]
} | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
127,
141
]
} |
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