text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
there is therefore a greater relative number of chondrocytes in the plane of section having the greatest abundance of oblique collagen fibers , suggesting a cellular basis for the collagenous architecture observed . | NA | {
"id": "C0225369",
"name": "chondrocytes",
"pos": [
48,
60
]
} | {
"id": "C0007634",
"name": "cellular",
"pos": [
157,
165
]
} |
the kinetics of mezlocillin , due to removal by nonrenal mechanisms , more closely resemble the kinetics of penicillin g and ampicillin than of carbenicillin and ticarcillin . | NA | {
"id": "C0025893",
"name": "mezlocillin",
"pos": [
16,
27
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
125,
135
]
} |
the kinetics of mezlocillin , due to removal by nonrenal mechanisms , more closely resemble the kinetics of penicillin g and ampicillin than of carbenicillin and ticarcillin . | NA | {
"id": "C0030827",
"name": "penicillin g",
"pos": [
108,
120
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
125,
135
]
} |
the kinetics of mezlocillin , due to removal by nonrenal mechanisms , more closely resemble the kinetics of penicillin g and ampicillin than of carbenicillin and ticarcillin . | NA | {
"id": "C0030827",
"name": "penicillin g",
"pos": [
108,
120
]
} | {
"id": "C0006976",
"name": "carbenicillin",
"pos": [
144,
157
]
} |
the median value of bioavailability ( relative to oral dose ) of methylprednisolone acetate based on unchanged methylprednisolone plasma levels was 14.2 % after rectal administration , suggesting that the drug exerts its therapeutic effect topically rather than systemically . | NA | {
"id": "C0600901",
"name": "methylprednisolone acetate",
"pos": [
65,
91
]
} | {
"id": "C0025815",
"name": "methylprednisolone",
"pos": [
111,
129
]
} |
children in grades 1 -- 4 , residents of a fluoride-deficient community in new york , rinsed an average of 49 times during 2 school years using a 0.2 % neutral naf solution . | NA | {
"id": "C0016327",
"name": "fluoride",
"pos": [
43,
51
]
} | {
"id": "C0037508",
"name": "naf",
"pos": [
160,
163
]
} |
the samples were analyzed for red blood cell , packed cell volume , hemoglobin , platelet , white blood cell , absolute number for leukocytes , and erythrocyte fragility and serum calcium , inorganic phosphorus , sodium , potassium , chloride , magnesium , alkaline phosphatase , icterus index unit , bilirubin , blood u... | NA | {
"id": "C0001899",
"name": "glutamic pyruvic transaminase",
"pos": [
395,
424
]
} | {
"id": "C0002594",
"name": "transaminase",
"pos": [
447,
459
]
} |
( 5 ) serum ferritin concentrations in disease -- hemochromatosis -- secondary iron overload -- liver damage -- infection and chronic disease -- cancer . | NA | {
"id": "C0018995",
"name": "hemochromatosis",
"pos": [
50,
65
]
} | {
"id": "C0282193",
"name": "iron overload",
"pos": [
79,
92
]
} |
gestational age , birth weight , and final weight at discharge from hospitals were the same in both groups . | NA | {
"id": "C0005612",
"name": "birth weight",
"pos": [
18,
30
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
43,
49
]
} |
the antibacterial activities of three aminopenicillins ampicillin , epicillin and amoxycillin were compared in vitro and in vivo . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
55,
65
]
} | {
"id": "C0002645",
"name": "amoxycillin",
"pos": [
82,
93
]
} |
microscopical observation of the cells exposed to ampicillin and epicillin for 1 h showed the presence of filamentous forms which lysed slowly , whereas cells exposed to amoxycillin for the same period rapidly . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
50,
60
]
} | {
"id": "C0002645",
"name": "amoxycillin",
"pos": [
170,
181
]
} |
epicillin was similar to or slightly less active than ampicillin against experimental mouse infections , and against the majority of infections both compounds were significantly less effective than amoxycillin by the oral and subcutaneous routes of administration . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
54,
64
]
} | {
"id": "C0002645",
"name": "amoxycillin",
"pos": [
198,
209
]
} |
10 of 11 clinical isolates of serratia marcescens yielded small numbers ( 10 ( -7 ) to 10 ( -8 ) ) of 'gray ' colony-type variants after selection with either amikacin , gentamicin or kanamycin , of which most proved resistant against all of the following aminoglycoside antibiotics : amikacin , gentamicin , kanamycin ,... | NA | {
"id": "C0002499",
"name": "amikacin",
"pos": [
159,
167
]
} | {
"id": "C0022487",
"name": "kanamycin",
"pos": [
309,
318
]
} |
10 of 11 clinical isolates of serratia marcescens yielded small numbers ( 10 ( -7 ) to 10 ( -8 ) ) of 'gray ' colony-type variants after selection with either amikacin , gentamicin or kanamycin , of which most proved resistant against all of the following aminoglycoside antibiotics : amikacin , gentamicin , kanamycin ,... | NA | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
170,
180
]
} | {
"id": "C0037209",
"name": "sisomicin",
"pos": [
345,
354
]
} |
10 of 11 clinical isolates of serratia marcescens yielded small numbers ( 10 ( -7 ) to 10 ( -8 ) ) of 'gray ' colony-type variants after selection with either amikacin , gentamicin or kanamycin , of which most proved resistant against all of the following aminoglycoside antibiotics : amikacin , gentamicin , kanamycin ,... | NA | {
"id": "C0027780",
"name": "netilmicin",
"pos": [
332,
342
]
} | {
"id": "C0037209",
"name": "sisomicin",
"pos": [
345,
354
]
} |
tissue for histopathologic examination was obtained at each operation and demonstrated astrocytoma in 13 patients , glioblastoma in 6 , 'no tumor seen ' in 5 and ependymoma in 2 . | NA | {
"id": "C0004114",
"name": "astrocytoma",
"pos": [
87,
98
]
} | {
"id": "C0017636",
"name": "glioblastoma",
"pos": [
116,
128
]
} |
astrocytomas were usually located in the upper brain stem , and all of the glioblastomas were located in the medulla . | NA | {
"id": "C0004114",
"name": "astrocytomas",
"pos": [
0,
12
]
} | {
"id": "C0017636",
"name": "glioblastomas",
"pos": [
75,
88
]
} |
2 patients with no tumor were treated , one as a glioblastoma multiforme , subsequently verified at postmortem examination , and one as a midbrain astrocytoma . | NA | {
"id": "C0017636",
"name": "glioblastoma multiforme",
"pos": [
49,
72
]
} | {
"id": "C0004114",
"name": "astrocytoma",
"pos": [
147,
158
]
} |
in brain abscess , one may note angiographic evidence of a space-occupying lesion , a capsular stain in the granulation tissue surrounding the abscess , 'halo ' formation and 'pooling ' of contrast media in the sulci , and 'laminar ' staining of the gyri . | NA | {
"id": "C0006105",
"name": "brain abscess",
"pos": [
3,
16
]
} | {
"id": "C0000833",
"name": "abscess",
"pos": [
143,
150
]
} |
through addition of amino acids the decreased branched chain amino acids returned to normal levels , whereas the significant fall in plasma proteins with short half-life remained unchanged . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
20,
31
]
} | {
"id": "C0002521",
"name": "branched chain amino",
"pos": [
46,
66
]
} |
sds gel electrophoresis of the chromosomal nonhistone proteins showed them to be very similar to nuclear nonhistone proteins except for the presence of more actin and tubulin . | NA | {
"id": "C0008600",
"name": "chromosomal nonhistone proteins",
"pos": [
31,
62
]
} | {
"id": "C0028589",
"name": "nuclear",
"pos": [
97,
104
]
} |
liver function in physically trained subjects : galactose elimination capacity , plasma disappearance of indocyanine green , and aminopyrine metabolism in long-distance runners . | NA | {
"id": "C0221102",
"name": "elimination",
"pos": [
58,
69
]
} | {
"id": "C0025519",
"name": "metabolism",
"pos": [
141,
151
]
} |
it seems that the 2-hr aminopyrine score and prothrombin time are more likely to give a quantitative estimate of total functioning parenchymal mass which is left unaffected by hepatocellular disease in cirrhosis , than the other commonly used liver tests . | NA | {
"id": "C0023895",
"name": "hepatocellular disease",
"pos": [
176,
198
]
} | {
"id": "C0023890",
"name": "cirrhosis",
"pos": [
202,
211
]
} |
well-delineated colinic radioactivity 6 hr after injection which persists for 3 to 5 days indicates the presence of uc in patients with ibd , while a negative scan is more consistent with active cd . | NA | {
"id": "C0021390",
"name": "ibd",
"pos": [
136,
139
]
} | {
"id": "C0010346",
"name": "cd",
"pos": [
195,
197
]
} |
an analysis of the occurrence of gallbladder disease ( ie , cholelithiasis , cholecystitis , cholecystectomy ) in 210 consecutive patients with primary hyperlipoproteinemia showed that the prevalence of gallbladder disease was 8 % , 18 % , and 42 % in males with type iia , iib , and iv hyperlipoproteinemia , and 22 % ,... | NA | {
"id": "C0008325",
"name": "cholecystitis",
"pos": [
77,
90
]
} | {
"id": "C0016977",
"name": "of gallbladder disease",
"pos": [
200,
222
]
} |
endogenous bile flow and biliverdin and bilirubin excretory rates and the excretion of bile pigments after a bilirubin load were measured in various snakes . | NA | {
"id": "C0005446",
"name": "biliverdin",
"pos": [
25,
35
]
} | {
"id": "C0005437",
"name": "bilirubin",
"pos": [
109,
118
]
} |
extensive intracutaneous testing with highly purified insulins , including sheep and human insulin , revealed an allergy of the immediate type against the insulin molecule itself . | NA | {
"id": "C0795635",
"name": "human insulin",
"pos": [
85,
98
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
155,
162
]
} |
three patients with a bodyweight less than 75 % of the idealweight died , steatorrhea ( 8 -- 19 g/die ) , bloodsugar oscillation in the 24 h-profile ( 40 -- 820 mg % ) and an intrinsic-factor-non-responsive vitamin b12-malabsorption without megaloblastic anemia . | NA | {
"id": "C0038238",
"name": "steatorrhea",
"pos": [
74,
85
]
} | {
"id": "C0024523",
"name": "malabsorption",
"pos": [
219,
232
]
} |
six barbiturates with diverse time-action characteristics -- thiopental , pentobarbital , butabarbital , phenobarbital , diphenylbarbiturate , and barbital -- were evaluated for `` '' anticonvulsant '' '' and `` '' neurotoxic '' '' effects . | NA | {
"id": "C0004745",
"name": "barbiturates",
"pos": [
4,
16
]
} | {
"id": "C0030883",
"name": "pentobarbital",
"pos": [
74,
87
]
} |
six barbiturates with diverse time-action characteristics -- thiopental , pentobarbital , butabarbital , phenobarbital , diphenylbarbiturate , and barbital -- were evaluated for `` '' anticonvulsant '' '' and `` '' neurotoxic '' '' effects . | NA | {
"id": "C0004745",
"name": "barbiturates",
"pos": [
4,
16
]
} | {
"id": "C0004743",
"name": "barbital",
"pos": [
147,
155
]
} |
when msm was administered to patients on stable pb or primidone therapy , the mean concentrations of pb increased by statistically significant amounts of 38 and 40 % , respectively . | NA | {
"id": "C0033148",
"name": "primidone",
"pos": [
54,
63
]
} | {
"id": "C0031412",
"name": "pb",
"pos": [
101,
103
]
} |
a cyanide-resistant cytochrome , tentatively identified as cytochrome d , appeared in the late exponential phase of growth . | NA | {
"id": "C0010798",
"name": "cytochrome",
"pos": [
20,
30
]
} | {
"id": "C0056960",
"name": "cytochrome d",
"pos": [
59,
71
]
} |
while the fatty acid composition of the lysophospholipids is independent of the degree of delipidation , the composition of the residual free fatty acids is found to change with the albumin concentration . | NA | {
"id": "C0015684",
"name": "fatty",
"pos": [
10,
15
]
} | {
"id": "C0015688",
"name": "free fatty acids",
"pos": [
137,
153
]
} |
reactivation of the ca2+-atpase by oleate leads to reasonable activities at room temperature as long as a minimum of about 30 lysophospholipid molec-les per atpase is left . | NA | {
"id": "C0001476",
"name": "ca2",
"pos": [
20,
23
]
} | {
"id": "C0001473",
"name": "atpase",
"pos": [
157,
163
]
} |
monovalent cations can also promote the binding reaction as well as divalent cations but the complex formed with monovalent cation is unstable . | NA | {
"id": "C0007449",
"name": "monovalent cations",
"pos": [
0,
18
]
} | {
"id": "C0007447",
"name": "cation",
"pos": [
124,
130
]
} |
monovalent cations can also promote the binding reaction as well as divalent cations but the complex formed with monovalent cation is unstable . | NA | {
"id": "C0007448",
"name": "divalent cations",
"pos": [
68,
84
]
} | {
"id": "C0007447",
"name": "cation",
"pos": [
124,
130
]
} |
incorporation of n-acetylglucosamine into endogenous lipid and protein acceptors was investigated on heavy microsomes from rat liver , incubated with udp-n-acetyl [ 14c ] glucosamine and gdp-mannose in the absence of detergent . | NA | {
"id": "C0001056",
"name": "acetylglucosamine",
"pos": [
19,
36
]
} | {
"id": "C0017718",
"name": "glucosamine",
"pos": [
171,
182
]
} |
the time-course of n-acetylglucosamine incorporation in these products was compatible with the pathway of dolichyl diphosphate glycoconjugates for the biosynthesis of the core portion of saccharide chains linked to asparagine residues of glycoproteins . | NA | {
"id": "C0017906",
"name": "glycoconjugates",
"pos": [
127,
142
]
} | {
"id": "C0017968",
"name": "glycoproteins",
"pos": [
238,
251
]
} |
they may stimulate directly the reaction forming dolichyl diphosphate n , n'-diacetylchitobiose from dolichyl diphosphate n-acetylglucosamine , or activate the synthesis of this latter intermediate from a particular pool of dolichyl monophosphate which is readily converted afterwards into disaccharide and oligosacchari... | NA | {
"id": "C0012611",
"name": "disaccharide",
"pos": [
290,
302
]
} | {
"id": "C0028959",
"name": "oligosaccharide",
"pos": [
307,
322
]
} |
the self-digestion experiments at ph 4 using the sealed ghosts showed higher availability to ph-3 protease of spectrin and iva protein than the other membrane proteins , also suggesting the localization of an acid protease in the inner membranes of erythrocytes . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
127,
134
]
} | {
"id": "C0025252",
"name": "membrane proteins",
"pos": [
150,
167
]
} |
among secretin analogs that were found to have low affinity for vasoactive intestinal peptide binding sites , [ 4-alanine , 5-valine ] secretin , that resembles vasoactive intestinal peptide at the first seven amino acids at the n-terminal end , was a partial agonist of vasoactive peptide at the first seven amino acids... | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
114,
121
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
309,
320
]
} |
one such rna species of mr 2.7 x 10 ( 6 ) shows sequence homology with both the chloroplast 23-s rrna ( mr = 1.05 x 10 ( 6 ) ) and 16-s rrna ( mr = 0.56 x 10 ( 6 ) ) , as judged by dna/rna competition hybridization . | NA | {
"id": "C0035701",
"name": "rrna",
"pos": [
97,
101
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
185,
188
]
} |
the 1.28 x 10 ( 6 ) -mr rna shows 80.5 % sequence homology with the 1.05 x 10 ( 6 ) -mr rrna and the 0.71/0.75 x 10 ( 6 ) -mr rna mixture shows 76 % sequence homology with the 0.56 x 10 ( 6 ) -mr rrna . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
24,
27
]
} | {
"id": "C0035701",
"name": "rrna",
"pos": [
196,
200
]
} |
chloroplasts isolated from young spinach leaves incorporate [ 3h ] uridine into rna species which co-electrophorese with 5-s rrna and trna , but show very little incorporation into 4.5-s rrna . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
80,
83
]
} | {
"id": "C0035701",
"name": "rrna",
"pos": [
187,
191
]
} |
the microviscosity of unilamellar vesicles of dimyristoyl-3-sn-phosphatidylcholine and that of phosphatidylcholine . apoprotein complexes was followed by fluorescence depolarization after labeling with 1,6-diphenyl-1,3,5-hexatriene . | NA | {
"id": "C0012456",
"name": "dimyristoyl",
"pos": [
46,
57
]
} | {
"id": "C1959616",
"name": "phosphatidylcholine",
"pos": [
95,
114
]
} |
the transition temperature from gel-crystalline to liquid-crystalline phase in 24 degrees c for the dimyristoyl-phosphatidylcholine vesicles and is shifted to around 30 degrees c in the complexes between phosphatidylcholine and apoa-i , apoa-ii , apoc-i , apoc-iii proteins while the cooperativity of the transition is d... | NA | {
"id": "C0012456",
"name": "dimyristoyl-phosphatidylcholine",
"pos": [
100,
131
]
} | {
"id": "C1959616",
"name": "phosphatidylcholine",
"pos": [
204,
223
]
} |
however , investigation of erythrocyte rheology , glucose-6-phosphate dehydrogenase , serum concentrations of caeruloplasmin and serotonin , and urinary excretion of epinephrine , norepinephrine and vanillylmandelic acid gave normal results in both patients . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
166,
177
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
180,
194
]
} |
relative to antipyrine , the transport fraction of diazepam was 85 % , and that of nordiazepam was 84 % . | NA | {
"id": "C0012010",
"name": "diazepam",
"pos": [
51,
59
]
} | {
"id": "C0011279",
"name": "nordiazepam",
"pos": [
83,
94
]
} |
the relatively high transfer of diazepam and nordiazepam can be attributed to their high lipid solubility , and the lower transfer of clorazepate is due to its polar nature . | NA | {
"id": "C0012010",
"name": "diazepam",
"pos": [
32,
40
]
} | {
"id": "C0011279",
"name": "nordiazepam",
"pos": [
45,
56
]
} |
the ic50 values ( nm concentrations inhibiting specific binding by 50 % ) were 0.9 for ( +/- ) -n-propyl-norapomorphine , 3.0 for dopamine , 7 for ( -- ) -adrenaline , 60 for ( -- ) -noradrenaline and 4000 for isoproterenol , a series of potencies compatible with properties for a dopaminergic site . | NA | {
"id": "C0013030",
"name": "dopamine",
"pos": [
130,
138
]
} | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
281,
293
]
} |
the ic50 values ( nm concentrations inhibiting specific binding by 50 % ) were 0.9 for ( +/- ) -n-propyl-norapomorphine , 3.0 for dopamine , 7 for ( -- ) -adrenaline , 60 for ( -- ) -noradrenaline and 4000 for isoproterenol , a series of potencies compatible with properties for a dopaminergic site . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
155,
165
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
183,
196
]
} |
the significance of this action of angiotensin ii depends on whether there is an effective brain renin-angiotensin system and on whether peripherally generated or administered angiotensin can reach sites in the brain where it can act on vasopressin release . | NA | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
35,
49
]
} | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
176,
187
]
} |
if blocker infusions produce effects that are opposite to exogenous aii infusions , it is evidence supporting a physiological role for endogenously generated angiotensin . | NA | {
"id": "C0003009",
"name": "aii",
"pos": [
68,
71
]
} | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
158,
169
]
} |
alpha -- adrenoreceptor blocking agents phentolamine and dibenzyline abolished the inhibitory action of the native forms of catecholamines ( norepinephrine , epinephrine , isoproterenol ) on the enzymatic activity under study . | NA | {
"id": "C0007412",
"name": "catecholamines",
"pos": [
124,
138
]
} | {
"id": "C0022245",
"name": "isoproterenol",
"pos": [
172,
185
]
} |
alpha -- adrenoreceptor blocking agents phentolamine and dibenzyline abolished the inhibitory action of the native forms of catecholamines ( norepinephrine , epinephrine , isoproterenol ) on the enzymatic activity under study . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
141,
155
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
158,
169
]
} |
epinephrine , norepinephrine , and isoproterenol induced circular contraction of isolated segments of canine intracerebral internal carotid artery . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
0,
11
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
14,
28
]
} |
of the 55 ibd serum samples tested , the 24 ulcerative colitis samples demonstrated significant binding ( 33.1 +/- 8.3 % , p = 0.02 ) , whereas the 31 crohn 's samples bound essentially normal amounts ( 29.2 +/- 7.4 % ) . | NA | {
"id": "C0021390",
"name": "ibd",
"pos": [
10,
13
]
} | {
"id": "C0010346",
"name": "crohn 's",
"pos": [
151,
159
]
} |
[ study of some serum lipid fractions ( cholesterol , total lipids , triglycerides and lipoproteins ) in aged subjects ] . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
22,
27
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
87,
99
]
} |
sera from the hepatocellular carcinoma patients were therefore tested for hepatitis b virus markers ( hbv surface antigen and antibody against hbv core antigen ) , and these were related to the patients ' histocompatibility antigens . | NA | {
"id": "C0003339",
"name": "surface",
"pos": [
106,
113
]
} | {
"id": "C0019628",
"name": "histocompatibility antigens",
"pos": [
205,
232
]
} |
none of the hla antigen frequencies was significantly different in the surface antigen-positive and the surface antigen-negative patients . | NA | {
"id": "C0019628",
"name": "hla",
"pos": [
12,
15
]
} | {
"id": "C0003339",
"name": "surface",
"pos": [
104,
111
]
} |
the concomitant increase of phospholipid fractions of supernatant shows that the erythrocyte membranes lose their phospholipids mainly by a passive way . | NA | {
"id": "C0771648",
"name": "of phospholipid fractions",
"pos": [
25,
50
]
} | {
"id": "C0031676",
"name": "phospholipids",
"pos": [
114,
127
]
} |
cells grown in this way are rich in proteins ( 62 % ) and essential amino acids ( lysine , phenylalanine , leucine , threonine and valine ) . | NA | {
"id": "C0002525",
"name": "essential amino acids",
"pos": [
58,
79
]
} | {
"id": "C0040005",
"name": "threonine",
"pos": [
117,
126
]
} |
acute administration of ethanol increased the cerebrocortical amino acids derived through the tricarboxylic acid cycle except for gaba and decreased the plasma alanine , valine , isoleucine , leucine , and phenylalanine whereas chronic administration of ethanol caused no significant changes in the cerebrocortical amino... | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
62,
73
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
442,
449
]
} |
acute administration of ethanol increased the cerebrocortical amino acids derived through the tricarboxylic acid cycle except for gaba and decreased the plasma alanine , valine , isoleucine , leucine , and phenylalanine whereas chronic administration of ethanol caused no significant changes in the cerebrocortical amino... | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
62,
73
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
380,
387
]
} |
acute administration of ethanol increased the cerebrocortical amino acids derived through the tricarboxylic acid cycle except for gaba and decreased the plasma alanine , valine , isoleucine , leucine , and phenylalanine whereas chronic administration of ethanol caused no significant changes in the cerebrocortical amino... | NA | {
"id": "C0061472",
"name": "glutamic acid",
"pos": [
352,
365
]
} | {
"id": "C0017797",
"name": "glutamine",
"pos": [
368,
377
]
} |
definitions of the terms ischaemia , infarction and necrosis are presented and their significance in connection with sudden cardiac death is discussed . | NA | {
"id": "C0022116",
"name": "ischaemia",
"pos": [
25,
34
]
} | {
"id": "C0021308",
"name": "infarction",
"pos": [
37,
47
]
} |
3 ) the administration of the three branched chain amino acids together or leucine alone significantly increased the proportion of polysomes . | NA | {
"id": "C0002521",
"name": "branched chain",
"pos": [
36,
50
]
} | {
"id": "C0023401",
"name": "leucine",
"pos": [
75,
82
]
} |
5 ) it is suggested that the branched chain amino acids and specifically leucine may be required for the full protein anabolic response of muscles to insulin during a prolonged fast . | NA | {
"id": "C0002521",
"name": "branched chain amino acids",
"pos": [
29,
55
]
} | {
"id": "C0023401",
"name": "leucine",
"pos": [
73,
80
]
} |
muscle-type isozyme is the single form found in adult muscle , and is involved in the enzymes from heart , brain , red cell , and testis . | NA | {
"id": "C0022173",
"name": "isozyme",
"pos": [
12,
19
]
} | {
"id": "C0014442",
"name": "enzymes",
"pos": [
86,
93
]
} |
on the basis of both the km and ki values , the adult serum enzyme , at its optimal ph of 9.8 , bound spermidine and spermine more avidly than the smaller putrescine and aminoguanidine ; | NA | {
"id": "C0037871",
"name": "bound",
"pos": [
96,
101
]
} | {
"id": "C0037874",
"name": "smaller",
"pos": [
147,
154
]
} |
on the basis of both the km and ki values , the adult serum enzyme , at its optimal ph of 9.8 , bound spermidine and spermine more avidly than the smaller putrescine and aminoguanidine ; | NA | {
"id": "C0037871",
"name": "bound",
"pos": [
96,
101
]
} | {
"id": "C0034170",
"name": "putrescine",
"pos": [
155,
165
]
} |
exogenous cyclic amp and dibutyryl cyclic amp decreased the relative ciliary activity values of tracheal organ cultures . | NA | {
"id": "C0001455",
"name": "cyclic amp",
"pos": [
10,
20
]
} | {
"id": "C0012054",
"name": "dibutyryl cyclic amp",
"pos": [
25,
45
]
} |
the use of a radioimmunoassay for cyclic amp indicated that all of the tested substances increased intracellular cyclic amp levels to some extent ( from 3-fold for cholera toxin to almost 40-fold for dibutyryl cyclic amp ) . | NA | {
"id": "C0001455",
"name": "cyclic amp",
"pos": [
34,
44
]
} | {
"id": "C0012054",
"name": "dibutyryl cyclic amp",
"pos": [
200,
220
]
} |
the effects of endotoxin ( lipopolysaccharide [ lps ] ) on the pathogenesis of canine endotoxin shock were compared with those of lps which had interacted with polymyxin b sulfate prior to administration . | NA | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
15,
24
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
130,
133
]
} |
these data indicate that polymyxin b-modified lps , though significantly less lethal than unmodified lps , was capable of major interactions with several components of the humoral defense system , and support the concept that such interactions are not determinative in the pathogenesis of canine endotoxin shock . | NA | {
"id": "C0023810",
"name": "lps",
"pos": [
46,
49
]
} | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
296,
305
]
} |
upon chemical analysis the purified material was found to be strikingly similar in chemical composition to gram-negative lipopolysaccharide endotoxins . | NA | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
121,
139
]
} | {
"id": "C0014264",
"name": "endotoxins",
"pos": [
140,
150
]
} |
the material contained 15 % total fatty acid ( of which 50 % was beta-hydroxymyristic acid ) , 40 to 45 % neutral sugar ( glucose , galactose , and rhamnose ) , 11.5 % amino sugar , 12 % uronic acid , 2.5 % 2-keto-3-deoxyoctonic acid , 2 % heptose , 0.87 % phosphorus , and 1.6 % amino acid , thereby accounting for 85 t... | NA | {
"id": "C0007004",
"name": "sugar",
"pos": [
114,
119
]
} | {
"id": "C0002531",
"name": "amino sugar",
"pos": [
168,
179
]
} |
the ability to form antibody to lipopolysaccharide ( lps ) in these f1 mice did not influence either their natural resistance to endotoxin challenge or the effects of pretreatment with sublethal amounts of endotoxin on subsequent challenge with higher normally lethal doses . | NA | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
32,
50
]
} | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
206,
215
]
} |
thus , anti-lps antibody does not appear to play a critical role in protection of immune-defective ( cba/n x dba/2 ) f1 male mice to the lethal effects of endotoxin or to the protective effects of a single sublethal dose of endotoxin on subsequent endotoxin challenge . | NA | {
"id": "C0023810",
"name": "lps",
"pos": [
12,
15
]
} | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
248,
257
]
} |
the medium contained three l-amino acids ( arginine , aspartic acid , and alanine ) , basal and trace salts including 14 mm k2hpo4 , 14 mm glucose , and 140 mm glycerol . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
29,
40
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
74,
81
]
} |
the concentrations of amino acids which yielded most satisfactory results were 6 mm alanine , 13 mm aspartic acid , and 16 mm arginine . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
22,
33
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
84,
91
]
} |
antibody was purified by passing antiserum over an immunoadsorbent column containing homologous cell walls trapped in a cross-linked polyacrylamide gel . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
0,
8
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
33,
42
]
} |
among eight murnac dipeptides tested , murnac-l-ala-d-isogln , murnac-l-ala-d-gln , murnac-l-ala-d-glu , and murnac-l-ser-d-isogln were found active as an adjuvant in the stimulation of the primary and secondary reaginic anti-oa antibody production in a similar way to the cell wall pg and their fragments . | NA | {
"id": "C0017797",
"name": "gln",
"pos": [
57,
60
]
} | {
"id": "C0061472",
"name": "glu",
"pos": [
99,
102
]
} |
it is considerably more sensitive than passive hemagglutination , allowing detection of as little as 1.3 ng of specific immunoglobulin g antibody per ml in immune sera . | NA | {
"id": "C0003241",
"name": "little",
"pos": [
91,
97
]
} | {
"id": "C0020960",
"name": "immune sera",
"pos": [
156,
167
]
} |
aspartic acid , threonine , glutamic acid , lysine , alanine , and glycine were detected in these fractions , along with smaller amounts of 10 other amino acids . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
53,
60
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
149,
160
]
} |
aspartic acid , threonine , glutamic acid , lysine , alanine , and glycine were detected in these fractions , along with smaller amounts of 10 other amino acids . | NA | {
"id": "C0017890",
"name": "glycine",
"pos": [
67,
74
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
149,
160
]
} |
we also found that this much layer could be removed ( with a corresponding rise in bacterial adherence ) and that addition of exogenous gag ( heparin ) to the bladder prevented the expected rise in bacterial adherence . | NA | {
"id": "C0017973",
"name": "gag",
"pos": [
136,
139
]
} | {
"id": "C0019134",
"name": "heparin",
"pos": [
142,
149
]
} |
syngeneic antisera raised against three polyoma tumors , seyf-a seso and sewe , of strain aby , a and asw origin , respectively , contain antibodies directed against multiple specificities . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
10,
18
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
138,
148
]
} |
no clear correlation could be established with c-reactive protein , a well-documented acute phase reactant , or serum lysozyme levels that reflect the presence of monocyte activity . | NA | {
"id": "C0006560",
"name": "c-reactive protein",
"pos": [
47,
65
]
} | {
"id": "C0001347",
"name": "acute phase reactant",
"pos": [
86,
106
]
} |
levonorgestrel was twice as potent as the racemate in experiments in which norgestrel was effective . | NA | {
"id": "C0023566",
"name": "levonorgestrel",
"pos": [
0,
14
]
} | {
"id": "C0028368",
"name": "norgestrel",
"pos": [
75,
85
]
} |
these data reinforce earlier findings that levonorgestrel is responsible for all the biological activity found in norgestrel . | NA | {
"id": "C0023566",
"name": "levonorgestrel",
"pos": [
43,
57
]
} | {
"id": "C0028368",
"name": "norgestrel",
"pos": [
114,
124
]
} |
and ( 3 ) irradiation of adrenalectomized rats pre-treated with cortisone acetate induced more rna synthesis than did cortisone alone . | NA | {
"id": "C0056391",
"name": "cortisone acetate",
"pos": [
64,
81
]
} | {
"id": "C0010137",
"name": "cortisone",
"pos": [
118,
127
]
} |
carbonic anhydrase activity was found in the ciliary process of fresh human donor eyes , originating from an enzyme antigenically similar to the erythrocyte high-activity isoenzyme hca c . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
109,
115
]
} | {
"id": "C0022173",
"name": "isoenzyme",
"pos": [
171,
180
]
} |
using this procedure , adriamycin , daunorubicin , bleomycin camptothecin , mithramycin , hydroxyurea , 5-fluorouracil , thioguanine , 9-beta-d-arabinofuranosyladenine , 1-beta-d-arabinofuranosylcytosine ( ara-c ) , azacytidine and cyclocytidine were tested . | NA | {
"id": "C0010711",
"name": "arabinofuranosylcytosine",
"pos": [
179,
203
]
} | {
"id": "C0010557",
"name": "cyclocytidine",
"pos": [
232,
245
]
} |
the case history of a patient with tuberous sclerosis with adenoma sebaceum of pringle , periungual fibromata , epilepsy , retinal phacomata , renal hamartomata and cyst-like lesions of the phalanges is reported . | NA | {
"id": "C0041341",
"name": "adenoma sebaceum",
"pos": [
59,
75
]
} | {
"id": "C0018552",
"name": "hamartomata",
"pos": [
149,
160
]
} |
combinations of uar and atp with adult bovine hemoglobin or 2,3-dpg and atp with fetal hemoglobin also had no effect . | NA | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
46,
56
]
} | {
"id": "C0015936",
"name": "fetal hemoglobin",
"pos": [
81,
97
]
} |
during a survey of hemoglobin types in goats in the republic of malta a variant ( goat hb d-malta ) was discovered which differs from normal goat hb a by the substitution of an aspartyl residue in position beta 69 ( e13 ) by a glycyl residue . | NA | {
"id": "C0019016",
"name": "a",
"pos": [
7,
8
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
146,
148
]
} |
( b ) the proportion of the different types of mucins in the goblet cells vary along the crypts and villi with an increasing amount of sialomucins towards the villus top ; | NA | {
"id": "C0026682",
"name": "mucins",
"pos": [
47,
53
]
} | {
"id": "C0074477",
"name": "sialomucins",
"pos": [
135,
146
]
} |
proteolytic enzymes , protease and trypsin have recently been introduced to reduce the inconsistency hitherto encountered in the unlabelled antibody -- enzyme method using pap . | NA | {
"id": "C0030940",
"name": "proteolytic enzymes",
"pos": [
0,
19
]
} | {
"id": "C0030946",
"name": "protease",
"pos": [
22,
30
]
} |
the distribution and properties of cytochemically demonstrable phosphatases in the near-term guinea-pig placenta were examined using a strontium capture technique for sodium- and potassium-dependent adenosine triphosphatase ( na+ , k+-atpase ) and a lead capture technique for magnesium-dependent adenosine triphosphatas... | NA | {
"id": "C0001473",
"name": "atpase",
"pos": [
235,
241
]
} | {
"id": "C0001477",
"name": "mg2",
"pos": [
324,
327
]
} |
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