text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
we suggest that , in the postoperative or postinjury period , exercise has a stimulating effect on amino acid turnover in the skeletal muscle resulting from 1 ) amino acid ( mainly the branched-chain amino acids ) consumption for energg metabolism and gluconeogenesis , and 2 ) protein synthesis . | NA | {
"id": "C0002520",
"name": "amino",
"pos": [
99,
104
]
} | {
"id": "C0002521",
"name": "branched-chain amino acids",
"pos": [
185,
211
]
} |
to determine if inorganic nitrate pollutants cause increased airway reactivity in humans , 10 normal volunteers and 11 mild asthmatics inhaled a sodium nitrate ( nano3 ) aerosol with an aerodynamic diameter of 0.46 micron at a concentration of 7,000 microgram/m3 , a level 100 -- 1,000 times greater than reported urban ... | NA | {
"id": "C0074748",
"name": "sodium nitrate",
"pos": [
145,
159
]
} | {
"id": "C0028125",
"name": "nitrates",
"pos": [
331,
339
]
} |
an enhanced ability to produce nonshivering thermogenesis mediated by epinephrine or norepinephrine is not obvious because after the 30th immersion no enhanced calorigenic response to epinephrine or norepinephrine infusion was found . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
70,
81
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
199,
213
]
} |
the antibiotic was extracted from the growth medium with chloroform and purified by adsorption on silicic acid and by preparative silica gel thin-layer chromatography . | NA | {
"id": "C0037105",
"name": "silicic acid",
"pos": [
98,
110
]
} | {
"id": "C2936385",
"name": "silica gel",
"pos": [
130,
140
]
} |
the anti-tumor activity of the latter compound was less than that of both carminomycin and its 4-methyl ether ( daunomycin ) . | NA | {
"id": "C0007308",
"name": "carminomycin",
"pos": [
74,
86
]
} | {
"id": "C0011015",
"name": "daunomycin",
"pos": [
112,
122
]
} |
employing this method , d-lysergic acid diethylamide ( lsd-25 ) , d-2-acetyl lysergic acid diethylamide ( ald-52 ) , 1-methyl d-lysergic acid butano-lamide ( uml-491 ) , and 5-methoxy dimethyl tryptamine ( 5-meo-dmt ) were found to be as pharmacologically active as previously noted in fish and in man . | NA | {
"id": "C0024334",
"name": "d",
"pos": [
20,
21
]
} | {
"id": "C0369632",
"name": "lysergic acid",
"pos": [
128,
141
]
} |
employing this method , d-lysergic acid diethylamide ( lsd-25 ) , d-2-acetyl lysergic acid diethylamide ( ald-52 ) , 1-methyl d-lysergic acid butano-lamide ( uml-491 ) , and 5-methoxy dimethyl tryptamine ( 5-meo-dmt ) were found to be as pharmacologically active as previously noted in fish and in man . | NA | {
"id": "C0041248",
"name": "tryptamine",
"pos": [
193,
203
]
} | {
"id": "C0027183",
"name": "dmt",
"pos": [
212,
215
]
} |
the autolytic enzyme ( endo-beta-1,4-n-acetylmuramoylhydrolase ) of streptococcus faecium ( s. faecalis atcc 9790 ) was released in a soluble form from insoluble cell wall-autolytic enzyme complexes by treatment with dilute naoh at 0 degree c . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
14,
20
]
} | {
"id": "C0026741",
"name": "enzyme complexes",
"pos": [
182,
198
]
} |
since extraction of wall-enzyme complexes with 4.5 m licl at 0 degree c also removed methylpentose and phosphorus , release of enzyme with naoh did not appear to result from hydrolysis of covalent linkages . | NA | {
"id": "C0026741",
"name": "enzyme complexes",
"pos": [
25,
41
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
127,
133
]
} |
i.e. , no other phenazine accumulated . m-aminobenzoate inhibited a presumptive methylation step in pyocyanine biosynthesis , abolishing the formation of pyocyanine and aeruginosin pigments but increasing the yields of phenazine 1-carboxylic acid and oxychlororaphin . | NA | {
"id": "C0031375",
"name": "phenazine",
"pos": [
16,
25
]
} | {
"id": "C0034211",
"name": "pyocyanine",
"pos": [
154,
164
]
} |
the frequency of loss of genetic markers in this region was significantly higher than in other regions as determined with a 15- marker system . | NA | {
"id": "C0017393",
"name": "genetic markers",
"pos": [
25,
40
]
} | {
"id": "C0005516",
"name": "marker",
"pos": [
128,
134
]
} |
n-alcohols ( from methanol to octanol ) , phenethyl alcohol , and furfural lowered the activation temperature of p. blakesleeanus spores . | NA | {
"id": "C0001975",
"name": "alcohols",
"pos": [
2,
10
]
} | {
"id": "C0001963",
"name": "methanol",
"pos": [
18,
26
]
} |
comparison of denaturation by guanidine hydrochloride of the wild type tryptophan synthase alpha-subunit of escherichia coli and two mutant protein ( glu 49 replaced by met or gln ) . | NA | {
"id": "C0061472",
"name": "glu",
"pos": [
150,
153
]
} | {
"id": "C0017797",
"name": "gln",
"pos": [
176,
179
]
} |
in order to elucidate the roles of individual amino acid residues in the conformational stability of proteins , the denaturation by guanidine hydrochloride of the wild-type trytophan synthase alpha-subunit of escherichia coli and two mutant proteins , trpa33 ( glu 49 leads to met ) and trpa11 ( glu 49 leads to gln ) , ... | NA | {
"id": "C0061472",
"name": "glu",
"pos": [
261,
264
]
} | {
"id": "C0017797",
"name": "gln",
"pos": [
312,
315
]
} |
cd spectra of the two mutant proteins were similar to that of the wild-type protein . | NA | {
"id": "C1564139",
"name": "mutant proteins",
"pos": [
22,
37
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
76,
83
]
} |
to study flavin-protein and flavoprotein-ligand interaction , the absorption , cd and mcd spectra of riboflavin , fad , roseoflavin , the complexes of riboflavin and roseoflavin with riboflavin binding protein ( rbp ) , d-amino acid oxidase ( d-ao ) and its complexes with ligands were observed in the spectral region of... | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
16,
23
]
} | {
"id": "C0016223",
"name": "flavoprotein",
"pos": [
28,
40
]
} |
the mcd spectra showed similar patterns for all molecular complexes of riboflavin and fad , with two negative extrema of ellipticity which probably correspond to the faraday b-term , but the faraday a-term could not be observed , suggesting that there was no degeneracy in the excited state of flavins . | NA | {
"id": "C0035527",
"name": "riboflavin",
"pos": [
71,
81
]
} | {
"id": "C0016213",
"name": "flavins",
"pos": [
294,
301
]
} |
it is also suggested , based on a comparison of the absorption , cd and mcd spectra , that the vibronic structure of flavin was modified differently by each flavin-protein or flavoprotein-ligand interaction . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
164,
171
]
} | {
"id": "C0016223",
"name": "flavoprotein",
"pos": [
175,
187
]
} |
in alkaline gel electrophoresis , the troponin c-like protein formed a ca2+-dependent complex with troponin i or troponin t from skeletal muscle . | NA | {
"id": "C0041199",
"name": "complex",
"pos": [
86,
93
]
} | {
"id": "C0077404",
"name": "troponin t",
"pos": [
113,
123
]
} |
as reported previously , glycine , serine , aspartic acid , and beta-alanine are the predominant amino acids produced from equimolecular formaldehyde and hydroxylamine in a modified sea medium enriched with essential transition metal ions . | NA | {
"id": "C0017890",
"name": "glycine",
"pos": [
25,
32
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
97,
108
]
} |
each lipoprotein has an average dry weight composition of lipids ( 55 -- 72 % ) and apo-lipoproteins ( 28 -- 45 % ) containing protein , hexose , hexosamine , and sialic acid . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
58,
64
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
88,
100
]
} |
in each lipoprotein , triacylglycerol is a major lipid component ( 70 -- 83 % ) , followed by phospholipid ( 8 -- 16 % ) , cholesterol ( free and esterified , 8 -- 10 % ) , and free fatty acid ( 3 -- 4 % ) . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
8,
19
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
101,
106
]
} |
therefore , in contrast to 3t3-l1 fibroblasts , the ob 17 cells present , in culture , a self-modulation of insulin receptors and a loss of insulin sensitivity after chronic exposure to insulin . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
34,
45
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
58,
63
]
} |
the modified ( amino-acyl ) trna 's were compared for their abilities to bind to elongation factor tu ( ef-tu ) in the presence both of gtp and guanylylimidodiphosphate ( gmp-p ( nh ) p ) . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
136,
139
]
} | {
"id": "C0018366",
"name": "guanylylimidodiphosphate",
"pos": [
144,
168
]
} |
cell culture experiments showed that the globular domains of the tested procollagen peptides were biologically active but that peptides from the helical region of collagen had no effect . | NA | {
"id": "C0033235",
"name": "procollagen",
"pos": [
72,
83
]
} | {
"id": "C0009325",
"name": "collagen",
"pos": [
163,
171
]
} |
glutathione ( and glutathione disulfide ) had an equilibrium ( dissociation ) constant for the binding of about 10 microm , whereas bromosulfophthalein and the product had equilibrium constants of about 0.5 microm . | NA | {
"id": "C0017817",
"name": "glutathione",
"pos": [
0,
11
]
} | {
"id": "C0061516",
"name": "glutathione disulfide",
"pos": [
18,
39
]
} |
a recent report ( rothman , s.s. , and wilking , h. ( 1978 ) j. biol . chem . 253 , 3543-3549 ) claimed that the in vitro rabbit pancreas demonstrated nonparallel enzyme discharge after stimulation with cholecystokinin/pancreozymin , but that parallel discharge followed stimulation with the cooh-terminal octapeptide of... | NA | {
"id": "C0037167",
"name": "octapeptide",
"pos": [
306,
317
]
} | {
"id": "C0008328",
"name": "pancreozymin",
"pos": [
337,
349
]
} |
the oxidation-reduction potential of adrenodoxin is shifted about -100 mv when bound to reductase , and reduction of the iron-sulfur protein thus promotes dissociation of the complex . | NA | {
"id": "C0001657",
"name": "adrenodoxin",
"pos": [
37,
48
]
} | {
"id": "C0022095",
"name": "iron-sulfur protein",
"pos": [
121,
140
]
} |
this stainless steel , a trip ( transformation induced plasticity ) steel containing about 4 % mo , was compared with two alloys in current clinical use : type 316l stainless steel and cast vitallium . | NA | {
"id": "C0038239",
"name": "steel",
"pos": [
15,
20
]
} | {
"id": "C0002154",
"name": "alloys",
"pos": [
122,
128
]
} |
this stainless steel , a trip ( transformation induced plasticity ) steel containing about 4 % mo , was compared with two alloys in current clinical use : type 316l stainless steel and cast vitallium . | NA | {
"id": "C0038239",
"name": "steel",
"pos": [
15,
20
]
} | {
"id": "C0038126",
"name": "stainless steel",
"pos": [
165,
180
]
} |
the tests in rats and dogs indicated that the corrosion resistances of the trip steel and the type 316l stainless steel were similar and that the tissue reactions caused by these alloys were also similar . | NA | {
"id": "C0038239",
"name": "steel",
"pos": [
80,
85
]
} | {
"id": "C0038126",
"name": "stainless steel",
"pos": [
104,
119
]
} |
the tests in rats and dogs indicated that the corrosion resistances of the trip steel and the type 316l stainless steel were similar and that the tissue reactions caused by these alloys were also similar . | NA | {
"id": "C0038239",
"name": "steel",
"pos": [
80,
85
]
} | {
"id": "C0002154",
"name": "alloys",
"pos": [
179,
185
]
} |
however , in rhesus monkeys , the trip steel was shown to be susceptible to stress-corrosion cracking and much more susceptible to crevice corrosion than type 316l stainless steel . | NA | {
"id": "C0038239",
"name": "steel",
"pos": [
39,
44
]
} | {
"id": "C0038126",
"name": "stainless steel",
"pos": [
164,
179
]
} |
the amount of grafted protein , determined by the ninhydrin method , reveals that , at least , plasma proteins such as serum albumin and fibrinogen are grafted to the film surface in a monomolecular layer without undergoing a marked denaturation . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
22,
29
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
125,
132
]
} |
the alpha-amylase grafted onto the eva film showed a distinct enzymatic activity in hydrolysis of amylose and starch , but the activity was very low compared with that of the ungrafted , soluble alpha-amylase . | NA | {
"id": "C0002732",
"name": "amylose",
"pos": [
98,
105
]
} | {
"id": "C0038179",
"name": "starch",
"pos": [
110,
116
]
} |
cellular fibronectin produced by fibroblasts in vitro and fibronectin isolated from plasma are known to be very similar immunologically and biochemically . | NA | {
"id": "C0007634",
"name": "cellular",
"pos": [
0,
8
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
33,
44
]
} |
cation analysis shows that divalent ions are not lost from the embryos , but that ca2+ is redistributed within the subcellular fractions . | NA | {
"id": "C0007447",
"name": "cation",
"pos": [
0,
6
]
} | {
"id": "C0022023",
"name": "ions",
"pos": [
132,
136
]
} |
approximately 55 % of the materials transferred from the cells labeled with glucosamine could be solubilized by hyaluronidase and chondroitinase , and the rest was solubilized by neuraminidase and a glycosidase mixture . | NA | {
"id": "C0020197",
"name": "hyaluronidase",
"pos": [
112,
125
]
} | {
"id": "C0017976",
"name": "glycosidase",
"pos": [
199,
210
]
} |
approximately 55 % of the materials transferred from the cells labeled with glucosamine could be solubilized by hyaluronidase and chondroitinase , and the rest was solubilized by neuraminidase and a glycosidase mixture . | NA | {
"id": "C0027803",
"name": "neuraminidase",
"pos": [
179,
192
]
} | {
"id": "C0017976",
"name": "glycosidase",
"pos": [
199,
210
]
} |
following a period of amino acid starvation , transformed , but not normal cells , showed increased levels of transport for alpha-aminoisobutyric acid , proline and alanine , three amino acids which are transported primarily by the a transport system . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
165,
172
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
181,
192
]
} |
analysis of the size distribution of the products of cell-free rna synthesis showed that aminonucleoside pretreatment results in marked reduction in the synthesis of preribosomal 45s rna , abnormal accumulation of 32s rna , and reduced formation of mature ribosomal rna species in the in vitro system . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
63,
66
]
} | {
"id": "C0035701",
"name": "ribosomal rna",
"pos": [
256,
269
]
} |
exogenous diamines and polyamines added to rat hepatoma ( htc ) cells in culture rapidly decrease ornithine decarboxylase ( odc ) activity . | NA | {
"id": "C0011957",
"name": "diamines",
"pos": [
10,
18
]
} | {
"id": "C0032433",
"name": "polyamines",
"pos": [
23,
33
]
} |
human diploid skin fibroblasts derived from normal individuals and those with the testicular feminization syndrome ( tfm ) have been shown to be killed to the same degree by dihydrotestosterone in spite of the absence of high affinity cellular androgen receptors in the tfm fibroblasts . | NA | {
"id": "C0007634",
"name": "cellular",
"pos": [
235,
243
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
274,
285
]
} |
we investigated the relative contributions of phagocytosis and plasma membrane transport to the uptake of amino acids and a protein ( egg albumin ) in amounts which allow tetrahymena thermophila to grow and multiply . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
124,
131
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
138,
145
]
} |
electron-micriscopic observations also indicated that smooth microsomes can bind more conjugates than rough microsomes and this finding was consistent with the biochemical data that , on the protein basis , smooth microsomes comtain more cytochrome p-450 than rough microsomes , even after correction for ribosomal prote... | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
191,
198
]
} | {
"id": "C0035552",
"name": "ribosomal proteins",
"pos": [
305,
323
]
} |
the binding of [ 125a ] proinsulin was blocked completely by unlabeled insulin and was uneffected by bovine c-peptide , indicating a cross-reaction of proinsulin with antinsulin reaginic immunoglobulins and the absence of proinsulin-specific reaginic antibodies . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
27,
34
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
222,
232
]
} |
the binding of [ 125a ] proinsulin was blocked completely by unlabeled insulin and was uneffected by bovine c-peptide , indicating a cross-reaction of proinsulin with antinsulin reaginic immunoglobulins and the absence of proinsulin-specific reaginic antibodies . | NA | {
"id": "C0006558",
"name": "c-peptide",
"pos": [
108,
117
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
222,
232
]
} |
these observations suggest insulin , but not proinsulin , as the mediator of the immediate insulin allergic reaction . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
45,
55
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
91,
98
]
} |
the longitudinal study of the physiologic postnatal rise of testosterone may be useful to distinguish secretory defects from responsiveness abnormalities thus improving the choice of gender in male pseudohermaphrodites . | NA | {
"id": "C0079399",
"name": "gender",
"pos": [
183,
189
]
} | {
"id": "C0086582",
"name": "male",
"pos": [
193,
197
]
} |
the persistence of antibody to hepatitis a antigen ( anti-hav ) of the immunoglobulin m ( igm ) class was evaluated in 88 sera of 51 acute hepatitis a patients . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
19,
27
]
} | {
"id": "C0021017",
"name": "immunoglobulin",
"pos": [
71,
85
]
} |
from stool cultures obtained on subsequent days , toxin testing of individual colonies and pools revealed diminished efficacy of pooling with decreasing numbers of enterotoxin-positive isolates in the pool . | NA | {
"id": "C0040549",
"name": "toxin",
"pos": [
50,
55
]
} | {
"id": "C0014372",
"name": "enterotoxin",
"pos": [
164,
175
]
} |
amplification of endogenous cholinergic activity-produced by the intravenous injection of edrophonium , an acetylcholinesterase inhibitor which does not enter the central nervous system , into normal subjects-resulted in significant and briefly sustained increments in the plasma concentrations of norepinephrine ( 153+/... | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
298,
312
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
356,
367
]
} |
these increments were not attributable to reflex responses to hemodynamic changes and similar increments in plasma norepinephrine occurred in adrenalectomized ( epinephrine deficient ) patients . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
115,
129
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
161,
172
]
} |
thus , cholinergic activation results in direct stimulation of sympathetic postganglionic neurons , with augmented norepinephrine release , and of the adrenal medullae , with augmented epinephrine release , in man . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
115,
129
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
185,
196
]
} |
the role of angiotensin ii ( aii ) in maintaining glomerular and proximal tubular adaptations to chronic sodium depletion was assessed in subsets of groups 1 and 2 by the infusion of the aii antagonist saralasin at a rate of 1 mug/kg per min . | NA | {
"id": "C0003009",
"name": "aii",
"pos": [
29,
32
]
} | {
"id": "C0036193",
"name": "saralasin",
"pos": [
202,
211
]
} |
saralasin infusion revealed a significant effect of aii on rpf and afferent arteriolar resistance in chronic sodium depletion , but no effect of aii on either efferent arteriolar resistance or the decrease in l ( p ) a could be demonstrated . | NA | {
"id": "C0036193",
"name": "saralasin",
"pos": [
0,
9
]
} | {
"id": "C0003009",
"name": "aii",
"pos": [
145,
148
]
} |
the marked changes observed during saralasin infusion in the chronically sodium-depleted rat reveal important modifying effects of endogenously generated aii on both the glomerulus and proximal tubule . | NA | {
"id": "C0036193",
"name": "saralasin",
"pos": [
35,
44
]
} | {
"id": "C0003009",
"name": "aii",
"pos": [
154,
157
]
} |
the potent beta-adrenergic agonist , ( - ) isoproterenol ( 2 microm ) , ( - ) epinephrine ( 10 microm ) and ( - ) norepinephrine ( 10 microm ) stimulated the camp-dependent protein kinase in membranes , 38 +/- 7 % , 31 +/- 6 % , and 30 +/- 6 % , respectively . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
78,
89
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
114,
128
]
} |
the concentrations of ( - ) catecholamines that gave half-maximal stimulation of the membrane protein kinase were 0.17 microm for isoproterenol , 0.35 microm for epinephrine , and 0.63 microm for norepinephrine . | NA | {
"id": "C0007412",
"name": "catecholamines",
"pos": [
28,
42
]
} | {
"id": "C0022245",
"name": "isoproterenol",
"pos": [
130,
143
]
} |
the concentrations of ( - ) catecholamines that gave half-maximal stimulation of the membrane protein kinase were 0.17 microm for isoproterenol , 0.35 microm for epinephrine , and 0.63 microm for norepinephrine . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
162,
173
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
196,
210
]
} |
to more directly define platelet-pg interactions , a binding assay has been developed for platelet pg receptors with [ ( 3 ) h ] pgd ( 2 ) as ligand . | NA | {
"id": "C0033554",
"name": "pg",
"pos": [
33,
35
]
} | {
"id": "C0033558",
"name": "pgd",
"pos": [
129,
132
]
} |
pg competed with the [ ( 3 ) h ] pgd ( 2 ) binding site with a potency series : pgd ( 2 ) ( ic ( 50 ) = 0.08 mum ) > > pgi ( 2 ) ( ic ( 50 ) = 2 mum ) > pge ( 1 ) ( ic ( 50 ) = 6 mum ) > pgf ( 2alpha ) ( ic ( 50 ) = 8 mum ) . | NA | {
"id": "C0033554",
"name": "pg",
"pos": [
0,
2
]
} | {
"id": "C0033558",
"name": "pgd",
"pos": [
80,
83
]
} |
pg competed with the [ ( 3 ) h ] pgd ( 2 ) binding site with a potency series : pgd ( 2 ) ( ic ( 50 ) = 0.08 mum ) > > pgi ( 2 ) ( ic ( 50 ) = 2 mum ) > pge ( 1 ) ( ic ( 50 ) = 6 mum ) > pgf ( 2alpha ) ( ic ( 50 ) = 8 mum ) . | NA | {
"id": "C0033554",
"name": "pg",
"pos": [
0,
2
]
} | {
"id": "C0033559",
"name": "pge",
"pos": [
153,
156
]
} |
direct binding analysis will be a useful tool for studying the role of pg in regulating platelet function , as demonstrated by the selective loss of pgd ( 2 ) binding sites in patients with myeloproliferative disorders . | NA | {
"id": "C0033554",
"name": "pg",
"pos": [
71,
73
]
} | {
"id": "C0033558",
"name": "pgd",
"pos": [
149,
152
]
} |
separation of the perfusate lipoproteins by agarose gel filtration revealed that most of the apoe secreted by the livers of hypercholesterolemic rats is found in the vldl and ldl , whereas apoe secreted by the normal livers is distributed equally between vldl , high density lipoproteins , and a low molecular weight fra... | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
28,
40
]
} | {
"id": "C0023825",
"name": "vldl",
"pos": [
255,
259
]
} |
after isolation of the casein amino acids the carbon-14 was incorporated into proline only while nitrogen-15 was localized in aspartic acid , glutamic acid , alanine , serine , glycine , and the branched-chain amino acids . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
30,
41
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
158,
165
]
} |
after isolation of the casein amino acids the carbon-14 was incorporated into proline only while nitrogen-15 was localized in aspartic acid , glutamic acid , alanine , serine , glycine , and the branched-chain amino acids . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
30,
41
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
177,
184
]
} |
after isolation of the casein amino acids the carbon-14 was incorporated into proline only while nitrogen-15 was localized in aspartic acid , glutamic acid , alanine , serine , glycine , and the branched-chain amino acids . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
30,
41
]
} | {
"id": "C0002521",
"name": "branched-chain amino acids",
"pos": [
195,
221
]
} |
recent work has suggested that placental hormones , in particular placental lactogen , may be an important regulator of lactation capacity . | NA | {
"id": "C0032050",
"name": "placental hormones",
"pos": [
31,
49
]
} | {
"id": "C1314785",
"name": "placental lactogen",
"pos": [
66,
84
]
} |
b cells mediate cbh via antibody of igg1 isotype through mechanisms that involve fc receptors , which can be competitively blocked . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
24,
32
]
} | {
"id": "C0021017",
"name": "isotype",
"pos": [
41,
48
]
} |
the chick renal mitochondrial 25-hydroxyvitamin-d3-1 alpha-hydroxylase is composed of three proteins , namely , cytochrome p-450 , iron-sulfur protein ( ferredoxin ) and flavoprotein . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
92,
100
]
} | {
"id": "C0016223",
"name": "flavoprotein",
"pos": [
170,
182
]
} |
this binding of the pfc precursor to e was blocked by pretreating the lymphocyte with anti-human ig before e rosetting , indicating that the pfc precursor specifically bound to srbc by a surface ig molecule with binding specificity for sheep red blood cell determinants . | NA | {
"id": "C0018956",
"name": "pfc precursor",
"pos": [
20,
33
]
} | {
"id": "C0007634",
"name": "pfc",
"pos": [
141,
144
]
} |
this antiserum , once adsorbed by igd-depleted mouse serum bound to sepharose , was isotype specific as determined by radioimmunoassay and fluorescence activated cell sorter analysis , and bound to the same splenic lymphocyte surface molecules as a hybridoma produced monoclonal anti-mouse delta antibody . | NA | {
"id": "C0020843",
"name": "igd",
"pos": [
34,
37
]
} | {
"id": "C0021017",
"name": "isotype",
"pos": [
84,
91
]
} |
a method is described for the isolation of antibodies specific for immunoglobulin class determinants from antisera containing antibodies both for the immunoglobulin class and for its subclasses , using affinity chromatography . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
106,
114
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
126,
136
]
} |
a method is described for the isolation of antibodies specific for immunoglobulin class determinants from antisera containing antibodies both for the immunoglobulin class and for its subclasses , using affinity chromatography . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
43,
53
]
} | {
"id": "C0021017",
"name": "immunoglobulin class",
"pos": [
150,
170
]
} |
a simple microassay for detection of antibodies to fetal calf serum and related antigens and its application to the serological definition of human tumor antigens . | NA | {
"id": "C0003320",
"name": "antigens",
"pos": [
80,
88
]
} | {
"id": "C0003335",
"name": "tumor",
"pos": [
148,
153
]
} |
bovine serum albumin was incubated with fluorescein isothiocyanate , washed and then bound at equivalence with antibovine serum albumin . | NA | {
"id": "C0036774",
"name": "bovine serum albumin",
"pos": [
0,
20
]
} | {
"id": "C0036773",
"name": "serum albumin",
"pos": [
122,
135
]
} |
recent investigations indicate an abnormal binding of gluten or gliadin to lymphocytes or intestinal mucosa cells in gluten sensitive enteropathy . | NA | {
"id": "C2362561",
"name": "gluten",
"pos": [
54,
60
]
} | {
"id": "C0017622",
"name": "gliadin",
"pos": [
64,
71
]
} |
thus , the role of gliadin in the fixation in vivo , of antibodies or immune complexes to skin in dermatitis herpetiformis , remains obscure . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
56,
66
]
} | {
"id": "C0003313",
"name": "immune complexes",
"pos": [
70,
86
]
} |
in covalent photobinding to dna , 8-mop forms mainly monofunctional adducts , and to a lesser extent bifunctional adducts , showing a behavior similar to that of other linearly condensed furocoumarins ( psoralens ) ; | NA | {
"id": "C0016859",
"name": "furocoumarins",
"pos": [
187,
200
]
} | {
"id": "C0033858",
"name": "psoralens",
"pos": [
203,
212
]
} |
in contrast to the lipopolysaccharide from which they are derived , these polysaccharides contain no lipid a and less than 0.5 % fatty acids . | NA | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
19,
37
]
} | {
"id": "C0023767",
"name": "lipid a",
"pos": [
101,
108
]
} |
in contrast with human ldl and the lipoproteins of the hypercholesterolemic rabbit , the entire cd spectrum of human vldl shows increased ellipticity with decreasing temperature , which is completely reversible . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
35,
47
]
} | {
"id": "C0023825",
"name": "vldl",
"pos": [
117,
121
]
} |
the aetiology and pathogenesis of selected craniofacial anomalies ( robin complex , hemifacial microsomia , and craniosynostosis ) are considered from the perspective of syndromology . | NA | {
"id": "C0376634",
"name": "craniofacial anomalies",
"pos": [
43,
65
]
} | {
"id": "C0010278",
"name": "craniosynostosis",
"pos": [
112,
128
]
} |
the present study describes the qualitative reactions of a xenogeneic anti-idiotype ( id ) antiserum produced in a mouse-gamma-globulin-tolerant rabbit ( 5,936 ) against b6 anti-cba igg antibodies . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
91,
100
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
186,
196
]
} |
nzb/nzw mice spontaneously exhibit autoimmune disease similar to that seen in human systemic lupus erythematosus ( sle ) . | NA | {
"id": "C0004364",
"name": "autoimmune disease",
"pos": [
35,
53
]
} | {
"id": "C0024141",
"name": "systemic lupus erythematosus",
"pos": [
84,
112
]
} |
incubation of [ 3h ] arachidonic acid with the 17,000-g supernatant from homogenates of human neutrophils in the presence of indomethacin generated the unique metabolites 9-oh-5,7,11,14-eicosatetraenoic acid ( 9-hete ) and 8-hete , in addition to 12-hete , 11-hete and 5-hete . | NA | {
"id": "C0020349",
"name": "hete",
"pos": [
212,
216
]
} | {
"id": "C0044800",
"name": "12-hete",
"pos": [
247,
254
]
} |
the human neutrophil chemotactic activity of the hete products exhibited a rank-order of potency with 5-hete greater than 8-hete = 9-hete greater than 11-hete = 12-hete . | NA | {
"id": "C0020349",
"name": "hete",
"pos": [
49,
53
]
} | {
"id": "C0044800",
"name": "12-hete",
"pos": [
161,
168
]
} |
both uptake mechanisms are non-competitively inhibited by the potential antiparkinson drugs 1-aminoadamantane ( amantadine , d 1 : ki1 = 57 microm , ki2 = 96 microm ) and 1-amino-3,5-dimethyladamantane ( memantine , d 145 : ki1 = 97 microm , ki2 = 150 microm ) . | NA | {
"id": "C0002403",
"name": "amantadine",
"pos": [
112,
122
]
} | {
"id": "C0025242",
"name": "memantine",
"pos": [
204,
213
]
} |
rapid and essentially synchronous vitamin a deficiency was induced by the withdrawal of retinoic acid from mature ( 190 -- 210 g ) stringently vitamin a-deficient male rats reared by feeding early growth plateau ( 60 -- 70 g ) vitamin a-deprived rats diets first supplemented with and then lacking in 2 micrograms retino... | NA | {
"id": "C0040845",
"name": "retinoic acid",
"pos": [
88,
101
]
} | {
"id": "C0042839",
"name": "vitamin a",
"pos": [
227,
236
]
} |
the results show that sulphur affects apparent selenium excretion and suggest that the metabolism of these two elements is intimately related . | NA | {
"id": "C0221102",
"name": "excretion",
"pos": [
56,
65
]
} | {
"id": "C0025519",
"name": "metabolism",
"pos": [
87,
97
]
} |
the principal interference with collagen synthesis in the mandible occurs when bone proline is converted into hydroxyproline . | NA | {
"id": "C0033382",
"name": "proline",
"pos": [
84,
91
]
} | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
110,
124
]
} |
incorporation of naf or snf2 in the etching solutions highly increased the fluoride concentration of enamel . | NA | {
"id": "C0037508",
"name": "naf",
"pos": [
17,
20
]
} | {
"id": "C0016327",
"name": "fluoride",
"pos": [
75,
83
]
} |
the fluoride increase dependend on the fluoride concentration of the etching solution and was greater for naf than snf2 . | NA | {
"id": "C0016327",
"name": "fluoride",
"pos": [
4,
12
]
} | {
"id": "C0037508",
"name": "naf",
"pos": [
106,
109
]
} |
the relative potency of the surfactants in stimulating both absorption of the solutes and the release of polypeptides and lipids followed the order : anionic greater than non-ionic greater than cationic . | NA | {
"id": "C0003075",
"name": "anionic",
"pos": [
150,
157
]
} | {
"id": "C0022023",
"name": "ionic",
"pos": [
197,
202
]
} |
the relative potency of the surfactants in stimulating both absorption of the solutes and the release of polypeptides and lipids followed the order : anionic greater than non-ionic greater than cationic . | NA | {
"id": "C0022023",
"name": "ionic",
"pos": [
152,
157
]
} | {
"id": "C0007447",
"name": "cationic",
"pos": [
194,
202
]
} |
the metabolism and excretion of codeine and its metabolites in untreated urine of man , rat , dog , guinea-pig and rabbit have been examined . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
4,
14
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
19,
28
]
} |
both codeine and norcodeine were detected in the urine of all species but a new metabolite , hydrocodone , was found only in the urine from man , guinea-pig and dog . | NA | {
"id": "C0009214",
"name": "codeine",
"pos": [
5,
12
]
} | {
"id": "C0020264",
"name": "hydrocodone",
"pos": [
93,
104
]
} |
this investigation determined the effect of serum protein binding on the kinetics of sulfisoxazole distribution , metabolism , and excretion . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
114,
124
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
131,
140
]
} |
modified usp assay for simultaneous determination of aspirin and nonaspirin salicylates in aspirin and buffered aspirin tablets . | NA | {
"id": "C0036077",
"name": "salicylates",
"pos": [
76,
87
]
} | {
"id": "C0004057",
"name": "aspirin",
"pos": [
112,
119
]
} |
modified usp procedures are described for the simultaneous determination of nonaspirin salicylates and aspirin in aspirin and buffered aspirin tablets . | NA | {
"id": "C0036077",
"name": "salicylates",
"pos": [
87,
98
]
} | {
"id": "C0004057",
"name": "aspirin",
"pos": [
135,
142
]
} |
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