text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
a high-pressure liquid chromatographic method was developed that separates prednisolone from prednisone , prednisone from methylprednisolone succinate sodium , and hydrocortisone from hydrocortisone acetate or cortisone acetate . | NA | {
"id": "C0032950",
"name": "prednisone",
"pos": [
93,
103
]
} | {
"id": "C0025815",
"name": "methylprednisolone",
"pos": [
122,
140
]
} |
quantitative dexamethasone and dexamethasone sodium phosphate determinations in pharmaceutical dosage forms by high-pressure liquid chromatography . | NA | {
"id": "C0011777",
"name": "dexamethasone",
"pos": [
13,
26
]
} | {
"id": "C0113286",
"name": "dexamethasone sodium phosphate",
"pos": [
31,
61
]
} |
a high-pressure liquid chromatographic procedure for quantitative dexamethasone and dexamethasone sodium phosphate determinations in all types of commercially available pharmaceutical dosage forms was developed . | NA | {
"id": "C0011777",
"name": "dexamethasone",
"pos": [
66,
79
]
} | {
"id": "C0113286",
"name": "dexamethasone sodium phosphate",
"pos": [
84,
114
]
} |
the method also separates dexamethasone from its phosphate salt and separates dexamethasone or its salt from a number of inactive ingredients such as benzoic acid , benzyl alcohol , some colors , creatinine , and parabens . | NA | {
"id": "C0770565",
"name": "dexamethasone",
"pos": [
26,
39
]
} | {
"id": "C0011777",
"name": "dexamethasone",
"pos": [
78,
91
]
} |
the cellular accumulation and disposition of 7 ( r ) -o-methylnogarol ( 7-omen ) , a derivative of the anthracycline antibiotic , nogalamycin , were compared to those of daunorubicin . | NA | {
"id": "C0127527",
"name": "7-omen",
"pos": [
72,
78
]
} | {
"id": "C0028261",
"name": "nogalamycin",
"pos": [
130,
141
]
} |
the cellular accumulation and disposition of 7 ( r ) -o-methylnogarol ( 7-omen ) , a derivative of the anthracycline antibiotic , nogalamycin , were compared to those of daunorubicin . | NA | {
"id": "C0028261",
"name": "nogalamycin",
"pos": [
130,
141
]
} | {
"id": "C0011015",
"name": "daunorubicin",
"pos": [
170,
182
]
} |
[ 3h ] isoproterenol excretion and metabolism were studied in the isolated perfused rat kidney using a one-pass , non-recirculating perfusion system with constant infusion rates of [ 3h ] isoproterenol . | NA | {
"id": "C0221102",
"name": "excretion",
"pos": [
21,
30
]
} | {
"id": "C0025519",
"name": "metabolism",
"pos": [
35,
45
]
} |
chondrocytes isolated from calf articular cartilage by pretreatment with various enzymes prior to collagenase digestion were examined to determine the effect of enzymatic exposure on cell viability and to establish optimal conditions whereby freshly isolated cells could be used for short term metabolic studies . | NA | {
"id": "C0225369",
"name": "chondrocytes",
"pos": [
0,
12
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
259,
264
]
} |
members of the series , including both carboxylic acid salts and esters , have been found to exhibit oral activity in the rat passive cutaneous anaphylaxis ( pca ) test . | NA | {
"id": "C0007066",
"name": "carboxylic acid",
"pos": [
39,
54
]
} | {
"id": "C0014898",
"name": "esters",
"pos": [
65,
71
]
} |
the three-dimensional structures of various penicillins and cephalosporins are compared to the spatial characteristics of glycylglycine and the tetrahedral adducts formed when a nucleophile attaches to the amide carbonyl carbon of this dipeptide . | NA | {
"id": "C0017984",
"name": "glycylglycine",
"pos": [
122,
135
]
} | {
"id": "C0012512",
"name": "dipeptide",
"pos": [
236,
245
]
} |
a series of 1,3-bis ( alkanoyl ) -2- ( o-acetylsalicyloyl ) glycerides ( aspirin triglycerides ) having aspirin at the 2 position of glycerol and fatty acids at the 1 and 3 positions was prepared . | NA | {
"id": "C0017860",
"name": "glycerides",
"pos": [
60,
70
]
} | {
"id": "C0041004",
"name": "triglycerides",
"pos": [
81,
94
]
} |
the method used to determine the rate of fusion was based on the large difference in the dielectric constants of water and ice . | NA | {
"id": "C0043047",
"name": "water",
"pos": [
113,
118
]
} | {
"id": "C0020746",
"name": "ice",
"pos": [
123,
126
]
} |
the role of coronary artery injury and perfusion in the development of cardiac contusion secondary to nonpenetrating chest trauma . | NA | {
"id": "C0009938",
"name": "contusion",
"pos": [
79,
88
]
} | {
"id": "C0043253",
"name": "nonpenetrating",
"pos": [
102,
116
]
} |
epinephrine and norepinephrine ( 0.5 mg/kg ) injected intraperitoneally postburn increased shock mortality significantly ( p less than 0.05 ) ; | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
0,
11
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
16,
30
]
} |
after surgical removal of the right adrenal gland , containing a pheochromocytoma and a small paraganglioma , the patient was free of symptoms . | NA | {
"id": "C0031511",
"name": "pheochromocytoma",
"pos": [
65,
81
]
} | {
"id": "C0030421",
"name": "paraganglioma",
"pos": [
94,
107
]
} |
our observation of an immune complex glomerulonephritis and the cumulative data on idiopathic retroperitoneal fibrosis are consistent with the concept that the fibrosis may be a local expression of an immunologically mediated systemic disease . | NA | {
"id": "C0035357",
"name": "idiopathic retroperitoneal",
"pos": [
83,
109
]
} | {
"id": "C0016059",
"name": "fibrosis",
"pos": [
160,
168
]
} |
although blood loss per minute is comparable to levels in earlier studies the rapidity with which resection can be accomplished results in a marked reduction in operative blood loss . | NA | {
"id": "C0019080",
"name": "blood loss",
"pos": [
9,
19
]
} | {
"id": "C0079027",
"name": "operative blood",
"pos": [
161,
176
]
} |
no difference in the adhesive ability was found between fecal isolates of the strain causing urinary tract infection , isolated at or before onset of bacteriuria , and the urinary strain in symptomatic or asymptomatic patients . | NA | {
"id": "C0042029",
"name": "urinary tract infection",
"pos": [
93,
116
]
} | {
"id": "C0004659",
"name": "bacteriuria",
"pos": [
150,
161
]
} |
[ comparative double-blind trial of sisomicin and gentamicin in the treatment of complicated urinary tract infections ( author 's transl ) ] . | NA | {
"id": "C0037209",
"name": "sisomicin",
"pos": [
36,
45
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
50,
60
]
} |
3 ) in the case of streptococcal infections including scarlet fever , pharyngeal streptococci disappeared 1 approximately 2 days after administration and did not reappeared . | NA | {
"id": "C0038395",
"name": "streptococcal infections",
"pos": [
19,
43
]
} | {
"id": "C0036285",
"name": "scarlet",
"pos": [
54,
61
]
} |
the purified esterase from human intestinal mucosa was found to be one of the carboxylesterases . | NA | {
"id": "C0014894",
"name": "esterase",
"pos": [
13,
21
]
} | {
"id": "C0007067",
"name": "carboxylesterases",
"pos": [
78,
95
]
} |
the cell response in the efferent lymph of the stimulated node was the same regardless of whether inoculum consisted of autochthonous or allogeneic fesv-transformed sheep cells . | NA | {
"id": "C0007634",
"name": "the cell",
"pos": [
0,
8
]
} | {
"id": "C3485979",
"name": "allogeneic",
"pos": [
137,
147
]
} |
the phorbol ester 12-o-tetradecanoylphorbol-13-acetate ( tpa ) was used as the tumor promoter in a 7,12-dimethylbenz [ a ] anthracene ( dmba ) -initiated mouse skin system . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
4,
17
]
} | {
"id": "C0039654",
"name": "12-o-tetradecanoylphorbol-13-acetate",
"pos": [
18,
54
]
} |
in order to gain insight into the frequency and severity of non-candidal infections in children with cmcc , four patients with cmcc are described in detail and 60 previously reported cases are reviewed . | NA | {
"id": "C0006840",
"name": "candidal infections",
"pos": [
64,
83
]
} | {
"id": "C0006845",
"name": "cmcc",
"pos": [
127,
131
]
} |
the blood of 131 patients with myocardial infarction and of 131 patients who underwent operation and had no necrosis of the cardiac muscle was tested for the content of adrenaline , noradrenaline , and 17-oxycorticosteroids ( 17-ocs ) . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
169,
179
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
182,
195
]
} |
in patients who underwent operation but had no myocardial infarction , the content of adrenaline , noradrenaline , and 17-ocs increased before and during the operation and on the 1st postoperative day . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
86,
96
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
99,
112
]
} |
study of the clinical course of myocardial infarction , the mortality of ischemic heart disease and its morphological manifestations showed the `` '' rejuvenation '' '' of myocardial infarction and an increase in its incidence depending on the duration of residence under conditions of norilsk . | NA | {
"id": "C0151744",
"name": "the",
"pos": [
9,
12
]
} | {
"id": "C0027051",
"name": "myocardial infarcti",
"pos": [
32,
51
]
} |
the prostaglandin a content increases simultaneously , evidently for compensation , while the level of prostaglandin f is reduced . | NA | {
"id": "C0033554",
"name": "prostaglandin",
"pos": [
4,
17
]
} | {
"id": "C0033561",
"name": "prostaglandin f",
"pos": [
103,
118
]
} |
it was established that in blood of patients with ischemic heart disease due to atherosclerosis of the coronary arteries ( the diagnosis was verified in selective coronaroangiography ) the content of acylhydroperoxides grows while the activity of glutathione-peroxidase ii decreases . | NA | {
"id": "C1956346",
"name": "disease",
"pos": [
65,
72
]
} | {
"id": "C0003850",
"name": "atherosclerosis",
"pos": [
80,
95
]
} |
in choriogonin load stimulating the gonads , there is noticeable variability in the excretion of testosterone and epitestosterone , androstenedione , and 7-keto-dehydroepiandrosterone in the urine . | NA | {
"id": "C0039601",
"name": "testosterone",
"pos": [
97,
109
]
} | {
"id": "C0014594",
"name": "epitestosterone",
"pos": [
114,
129
]
} |
[ familial occurrence of elfin 's face ( williams-beurens syndrome =wbs ) and supravalvular aortic stenosis ( = svas ) ( author 's transl ) ] . | NA | {
"id": "C0175702",
"name": "williams-beurens syndrome",
"pos": [
41,
66
]
} | {
"id": "C0003499",
"name": "svas",
"pos": [
112,
116
]
} |
in the present study the involvement of the sympathetic nervous system in tetanus was investigated by serial determinations of plasma adrenaline ( a ) and noradrenaline ( na ) in 2 patients who developed severe symptoms of tetanus and the characteristic cardiovascular disturbances . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
134,
144
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
155,
168
]
} |
in a composite pheochromocytoma-ganglioneuroma ( associated with the syndrome of watery diarrhea , hypokalemia , and hypochlorhydria ) , five ganglioneuroblastomas , five ganglioneuromas ( two of which were associated with diarrheal syndromes ) , an unusual mixed neuroblastoma-ganglioneuroma , and four normal sympathet... | NA | {
"id": "C0206718",
"name": "ganglioneuroblastomas",
"pos": [
142,
163
]
} | {
"id": "C0027819",
"name": "neuroblastoma",
"pos": [
264,
277
]
} |
the peptide was also demonstrated in isolated ganglion cells in two pheochromocytomas but was not present in pheochromocytes , schwann cells , or undifferentiated neuroblastic cells in the neuroblastomas and ganglioneuroblastomas . | NA | {
"id": "C0027819",
"name": "neuroblastomas",
"pos": [
189,
203
]
} | {
"id": "C0206718",
"name": "ganglioneuroblastomas",
"pos": [
208,
229
]
} |
the subcellular sites of accumulation of cholesterol and cholesteryl esters in rabbit atheromatous cells , were investigated by morphologic and biochemical techniques . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
41,
52
]
} | {
"id": "C0008387",
"name": "cholesteryl esters",
"pos": [
57,
75
]
} |
together the results indicate that in rabbit atheromatous cells , lysosomes are the site of accumulation of intracellular cholesterol in excess of that structurally associated with membranes and that both cytoplasmic droplets and lysosomes are depot sites for cholesteryl esters . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
122,
133
]
} | {
"id": "C0008387",
"name": "cholesteryl esters",
"pos": [
260,
278
]
} |
this factor has been shown in cell culture to be an extremely potent mitogen and will induce dna synthesis and cell multiplication of a number of cells including smooth muscle cells , fibroblasts , and other mesenchymally derived cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
184,
195
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
230,
235
]
} |
giant cell arteritis exhibited different clinical forms , including : temporal arteritis , rheumatic polymyalgia , syndrome of the supra-aortic trunks , cranial arteritis in its ophthalmic and neurologic forms , and generalized arteritis . | NA | {
"id": "C0039483",
"name": "giant cell arteritis",
"pos": [
0,
20
]
} | {
"id": "C0003860",
"name": "arteritis",
"pos": [
228,
237
]
} |
the prognostic value of this test and the low correlation between bacteremia and endotoxemia are also commented on | NA | {
"id": "C0004610",
"name": "bacteremia",
"pos": [
66,
76
]
} | {
"id": "C0376618",
"name": "endotoxemia",
"pos": [
81,
92
]
} |
in a study of women attending ten north american lipid research clinics plasma total cholesterol , triglyceride , low density ( l.d.l . ) , very low density ( v.l.d.l . ) , and high density ( h.d.l . ) lipoprotein levels in those taking oral contraceptives ( o.c . ) and in those taking oestrogens for menopausal symptom... | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
49,
54
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
202,
213
]
} |
of the serum lipoprotein fractions , a beta-lipoprotein corresponding to low density lipoprotein was preferentially reduced by the drug treatment . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
13,
24
]
} | {
"id": "C0065058",
"name": "a",
"pos": [
139,
140
]
} |
among degradation products of lipopolysaccharides tested , lipid a preparations derived from the mild acetic acid hydrolysates of lipopolysaccharides were the most active , but the lipid a fractions prepared from the hydrolysates with 1 n-hcl were almost inactive . | NA | {
"id": "C0023810",
"name": "lipopolysaccharides",
"pos": [
30,
49
]
} | {
"id": "C0023767",
"name": "lipid a",
"pos": [
181,
188
]
} |
because of the widespread occurrence of elevated levels of copper in drinking water in areas where the water is corrosive and the households have copper piping , it is recommended that environmental health regulatory agencies develop a risk assessment concerning the effects of copper on those high risk groups who are p... | NA | {
"id": "C0599638",
"name": "drinking water",
"pos": [
69,
83
]
} | {
"id": "C0043047",
"name": "water",
"pos": [
103,
108
]
} |
etozolin may be classified as a diuretic similar to a thiazide derivative in its 24-h profile but behaves like a loop diuretic in its diuretic effect . | NA | {
"id": "C0012798",
"name": "diuretic",
"pos": [
32,
40
]
} | {
"id": "C0354100",
"name": "loop diuretic",
"pos": [
113,
126
]
} |
the karyotypic findings have been related to the cytogenetic experience in burkitt and other lymphomas , with emphasis being put on the importance of the 14q+ anomaly in lymphoproliferative diseases . | NA | {
"id": "C0024299",
"name": "lymphomas",
"pos": [
93,
102
]
} | {
"id": "C0024314",
"name": "lymphoproliferative diseases",
"pos": [
170,
198
]
} |
variations in the atomic composition , and mass and electron densities of polystyrene and polymethylmethacrylate ( pmm ) plastics were assessed from experimentally determined mass attenuation coefficients for 125i and 137cs gamma rays . | NA | {
"id": "C0032604",
"name": "polystyrene",
"pos": [
74,
85
]
} | {
"id": "C0032167",
"name": "plastics",
"pos": [
121,
129
]
} |
adsorbtion capacity for pig liver glycogen with respect to phosphorylase b ( am ) and microscopic dissociation constant of enzyme -- glycogen complex ( k ) have been determined ( am = 3.64 . 10 ( -6 ) moles of bound enzyme per 1 g of glycogen : k = 2.6 . 10 ( -7 ) m at 12.7 degrees , ph 6.8 ) . | NA | {
"id": "C0023902",
"name": "liver glycogen",
"pos": [
28,
42
]
} | {
"id": "C0017911",
"name": "glycogen",
"pos": [
234,
242
]
} |
increased incorporation of labeled acetate into the total histone fraction and reduced incorporation into acidic nuclear proteins were obtained . | NA | {
"id": "C0019652",
"name": "histone",
"pos": [
58,
65
]
} | {
"id": "C0028589",
"name": "nuclear proteins",
"pos": [
113,
129
]
} |
comparison of the electronic structure of natural nucleic bases and their analogs allows to suppose that the eas discriminates between adenine and cytosine , and uracil ( thymine ) and guanine , by electrostatic features : sign of the potential in the region of exocyclic substituents at c ( 4 ) of pyrimidines and c ( 5... | NA | {
"id": "C0001407",
"name": "adenine",
"pos": [
135,
142
]
} | {
"id": "C0034140",
"name": "purines",
"pos": [
326,
333
]
} |
comparison of the electronic structure of natural nucleic bases and their analogs allows to suppose that the eas discriminates between adenine and cytosine , and uracil ( thymine ) and guanine , by electrostatic features : sign of the potential in the region of exocyclic substituents at c ( 4 ) of pyrimidines and c ( 5... | NA | {
"id": "C0041917",
"name": "uracil",
"pos": [
162,
168
]
} | {
"id": "C0040087",
"name": "thymine",
"pos": [
171,
178
]
} |
for adenine and cytosine this sign is positive while for uracil ( thymine ) and guanine it is negative . | NA | {
"id": "C0041917",
"name": "uracil",
"pos": [
57,
63
]
} | {
"id": "C0040087",
"name": "thymine",
"pos": [
66,
73
]
} |
three forms ( e1 , e2 and e3 ) of leucyl-trna synthetase ( leurs ) were separated by deae-cellulose chromatography of total aminoacyl-trna synthetases from cow lactating mammary gland . | NA | {
"id": "C0023414",
"name": "leucyl-trna synthetase",
"pos": [
34,
56
]
} | {
"id": "C0002529",
"name": "aminoacyl-trna synthetases",
"pos": [
124,
150
]
} |
[ regulation of enzyme activity in adsorptive enzyme systems . ii . influence of dextran sulfate on catalytic properties of lactate dehydrogenase ( isozyme m4 ) ] . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
16,
22
]
} | {
"id": "C0022173",
"name": "isozyme",
"pos": [
148,
155
]
} |
it has been shown that the nucleotide derivatives of poly ( oligo ) -l-lysine are not involved in complementary interactions with the polynucleotides . | NA | {
"id": "C0028630",
"name": "nucleotide",
"pos": [
27,
37
]
} | {
"id": "C0032550",
"name": "polynucleotides",
"pos": [
134,
149
]
} |
it has been shown that the nucleotide derivatives of poly ( oligo ) -l-lysine are not involved in complementary interactions with the polynucleotides . | NA | {
"id": "C0028953",
"name": "oligo",
"pos": [
60,
65
]
} | {
"id": "C0032550",
"name": "polynucleotides",
"pos": [
134,
149
]
} |
on assay with ta100 with metabolic activation , decreases in both specific and total mutangenicities of condensates of high-tar cigarettes were observed with all the sugars tested except galactose and sucrose . | NA | {
"id": "C0242209",
"name": "sugars",
"pos": [
166,
172
]
} | {
"id": "C0038636",
"name": "sucrose",
"pos": [
201,
208
]
} |
because cefoxitin , a semisynthetic cephamycin , resists gonococcal penicillinase in vitro , we compared procaine penicillin g and cefoxitin in treatment of gonorrhea in an area where 40 per cent of isolates produce penicillinase . | NA | {
"id": "C0007736",
"name": "cephamycin",
"pos": [
36,
46
]
} | {
"id": "C0007557",
"name": "cefoxitin",
"pos": [
131,
140
]
} |
the drugs used most often for prophylaxis were cephalosporins , followed by benzyl penicillins , ampicillin and tetracyclines , in that order . | NA | {
"id": "C0030827",
"name": "benzyl penicillins",
"pos": [
76,
94
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
97,
107
]
} |
we assessed extravascular accumulation of albumin and fluid in primary myxedema by measuring metabolic turnover and transcapillary escape of 131i-labeled human albumin in seven patients . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
42,
49
]
} | {
"id": "C0304925",
"name": "human",
"pos": [
154,
159
]
} |
the cleavage specificity of a protease from thermoactinomyces vulgaris ( thermitase ) was determined by the insulin b-chain and the cleavability of casein and haemoglobin by this enzyme as compared to other proteases ( trypsin , chymotrypsin , proteases from bac . megaterium and cytophages ) . | NA | {
"id": "C0030946",
"name": "protease",
"pos": [
30,
38
]
} | {
"id": "C0030940",
"name": "proteases",
"pos": [
244,
253
]
} |
after reviewing the localization and metabolism of the vitamin and its phosphate esters , the effects of either thiamine deprivation or antimetabolites of thiamine on conduction and transmission , and the relationship between thiamine triphosphate and the genetic , neurological disease , subacute necrotizing encephalom... | NA | {
"id": "C0039840",
"name": "thiamine",
"pos": [
112,
120
]
} | {
"id": "C0039853",
"name": "thiamine",
"pos": [
226,
234
]
} |
spermine turnover , measured at a time when spermidine radioactivity had substantially declined , was extremely slow ( t 1/2 = 92 days ) . | NA | {
"id": "C0037874",
"name": "turnover",
"pos": [
9,
17
]
} | {
"id": "C0037871",
"name": "radioactivity",
"pos": [
55,
68
]
} |
administration of a single oral 2.5 mg dose of bromocriptine ( brc ) , a dopamine ( da ) receptor agonist , to normal male volunteers results in comparable marked decreases in resting supine plasma concentrations of da ( decrement 2 h after drug administration was 67 +/- 5 % ; mean +/- se ) , norepinephrine ( ne ; 63 +... | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
294,
308
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
333,
344
]
} |
[ aneurysms of the coronary arteries . apropos of a case of bilateral aneurysm successfully treated by surgery ] . | NA | {
"id": "C0010051",
"name": "aneurysms",
"pos": [
2,
11
]
} | {
"id": "C0002940",
"name": "aneurysm",
"pos": [
70,
78
]
} |
successful surgical management of multiple aneurysms of the coronary arteries by means of an aorto-coronary by-pass was later followed by equal success in the treatment of a double aneurysm of the carotid siphon . | NA | {
"id": "C0018789",
"name": "of",
"pos": [
31,
33
]
} | {
"id": "C0002940",
"name": "aneurysm",
"pos": [
181,
189
]
} |
within a ten-year scan ( 1967-1976 ) 207 insulinomas , 50 gastrinomas , 8 verner-morrison tumours , 5 glucagonomas and 12 endocrine pancreatic tumours with associated mea syndrome ( multiple endocrine adenomatosis ) were treated surgically at various university hospitals ( information obtained by questionnaire ) . | NA | {
"id": "C0027662",
"name": "mea syndrome",
"pos": [
167,
179
]
} | {
"id": "C0025267",
"name": "multiple endocrine adenomatosis",
"pos": [
182,
213
]
} |
rats implanted with a single morphine pellet for a short period of 72 h have been shown to have a lower concentration of enkephalin in the brain , as determined by a radioimmunoassay ( ria ) detecting leu- and met-enkephalin as well as another endogenous substance . | NA | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
121,
131
]
} | {
"id": "C0014295",
"name": "met-enkephalin",
"pos": [
210,
224
]
} |
at a 350-nmol dose all other indoles tested ( i.e. , 5-hydroxyindoleacetic acid , 5-methoxyindoleacetic acid , serotonin , n-acetylserotonin , tryptamine , 5-methoxytryptamine ) were less potent than melatonin to impair fast axonal flow . | NA | {
"id": "C0036751",
"name": "serotonin",
"pos": [
111,
120
]
} | {
"id": "C0000589",
"name": "5-methoxytryptamine",
"pos": [
156,
175
]
} |
we conclude that young polynesian children in new zealand are especially prone to a different pattern of asthma from european children . | NA | {
"id": "C0728836",
"name": "young",
"pos": [
17,
22
]
} | {
"id": "C0008059",
"name": "children",
"pos": [
126,
134
]
} |
cefoxitin ( mefoxin ) , a new semisynthetic cephamycin antibiotic , resistant to degradation by beta-lactamase enzymes produced by bacteria . | NA | {
"id": "C0007557",
"name": "cefoxitin",
"pos": [
0,
9
]
} | {
"id": "C0007736",
"name": "cephamycin",
"pos": [
44,
54
]
} |
these cells , as well as fibroblasts , were found to contain a well developed microtubular system sensitive to colcemid . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
6,
11
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
25,
36
]
} |
2 ) the orientation of microtubules in the epithelial cells , unlike in the fibroblasts , was not correlated with the stable or active state of the cell margin . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
76,
87
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
148,
152
]
} |
from experiments using vaccines prepared from cells or toxoid only , it was deduced that , although there is a measure of strain specific immunity , a good heterologous immunity can be established with a combined product provided that it contains adequate quantities of toxoid . | NA | {
"id": "C0042210",
"name": "vaccines",
"pos": [
23,
31
]
} | {
"id": "C0040555",
"name": "toxoid",
"pos": [
270,
276
]
} |
other common causes of upper airway obstruction include edema of the oropharynx and larynx , trauma , foreign body , and infection . | NA | {
"id": "C0043251",
"name": "trauma",
"pos": [
93,
99
]
} | {
"id": "C0016542",
"name": "foreign body",
"pos": [
102,
114
]
} |
because it may have several different causes , ncerotizing enterocolitis may be a syndrome rather than a specific disease . | NA | {
"id": "C0039082",
"name": "syndrome",
"pos": [
82,
90
]
} | {
"id": "C0012634",
"name": "disease",
"pos": [
114,
121
]
} |
detection of circulating and intra-articular soluble immune complexes , has been done in 28 rheumatoid arthritis , 8 mixed connective tissue diseases and 8 other connective tissue diseases . | NA | {
"id": "C0026272",
"name": "mixed connective tissue diseases",
"pos": [
117,
149
]
} | {
"id": "C0009782",
"name": "connective tissue diseases",
"pos": [
162,
188
]
} |
this is the second example to be established of mutual stimulation of rna binding by two ribosomal proteins or protein complexes , and suggests that this may be an important principle governing ribosomal protein-rna assembly . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
70,
73
]
} | {
"id": "C0035701",
"name": "ribosomal",
"pos": [
194,
203
]
} |
this is the second example to be established of mutual stimulation of rna binding by two ribosomal proteins or protein complexes , and suggests that this may be an important principle governing ribosomal protein-rna assembly . | NA | {
"id": "C0035552",
"name": "ribosomal proteins",
"pos": [
89,
107
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
204,
211
]
} |
4 ) both gm 637 fibroblasts and xeroderma pigmentosum fibroblasts ( 12-ro ) ( xp-12 ) have similar ability to remove ethyl products , except for o6-ethyl g which persists to a greater extent in xp12 cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
16,
27
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
199,
204
]
} |
the enzyme eluted from hydroxyapatite , phosphocellulose and heparin-cellulose between 100 -- 250 mm potassium phosphate but did not bind to deae-cellulose . | NA | {
"id": "C0007648",
"name": "cellulose",
"pos": [
47,
56
]
} | {
"id": "C0011050",
"name": "deae-cellulose",
"pos": [
141,
155
]
} |
it is assumed that the numerous silica particles which were identified by x-ray microanalysis under the scanning electron microscope and recovered from the mineral ash after incineration were accidentally implanted into the skin at the time of an injury 26 years previously . | NA | {
"id": "C0037098",
"name": "silica",
"pos": [
32,
38
]
} | {
"id": "C0026162",
"name": "mineral",
"pos": [
156,
163
]
} |
t antigen and interferon were formed simultaneously in chick embryo fibroblast cells infected with human adenovirus type 12 , and therefore the adenovirus-specific t antigen was resistant to the action of endogenous interferon synthetized by the same cells . | NA | {
"id": "C0016030",
"name": "fibroblast cells",
"pos": [
68,
84
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
251,
256
]
} |
until the efficiency , indications and mode of application of immunotherapy have been clearly established desensitization is preferable , provided the allergen has been identified and proved to be active , and exposure to the antigen can not be avoided . | NA | {
"id": "C0002092",
"name": "allergen",
"pos": [
151,
159
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
226,
233
]
} |
but beta-adrenoblockers aggravated decompensation and the sth level remained unchanged . alpha and beta-adrenoblockers decreased the urinary adrenaline excretion and elevated noradrenaline , dophamine and dopa excretion , irrespective of blood glycemia . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
141,
151
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
175,
188
]
} |
the eif-2 kinase activated as part of this sequence has been tentatively identified as the same protein kinase that is activated by heme deficiency as part of the hemin-controlled repressor ( hcr ) system . | NA | {
"id": "C0018966",
"name": "heme",
"pos": [
132,
136
]
} | {
"id": "C0018988",
"name": "hemin",
"pos": [
163,
168
]
} |
this reaction sequence is not detectably affected by heme or cyclic amp and thus appears to provide an alternative mechanism , independent of heme , for activation of the cyclic amp-independent eif-2 kinase of the hcr system . | NA | {
"id": "C0018966",
"name": "heme",
"pos": [
53,
57
]
} | {
"id": "C0018988",
"name": "hcr",
"pos": [
214,
217
]
} |
homogeneous reca protein catalyzes the hybridization of single-stranded dna to homologous regions in duplex dna . | NA | {
"id": "C0012935",
"name": "single-stranded dna",
"pos": [
56,
75
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
108,
111
]
} |
notable physiological amines that do not support a rapid o2 reaction under the above conditions include histamine , serotonin , epinephrine , norepinephrine , spermidine , spermine , and cadaverine . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
128,
139
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
142,
156
]
} |
earlier studies had provided evidence that mitochondrial rrnas in neurospora are synthesized via a 32s precursor rna that contains sequences for both the mature 19s and 25s rna species . | NA | {
"id": "C0035701",
"name": "rrnas",
"pos": [
57,
62
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
173,
176
]
} |
reaction of covalently closed circular pm2 bacteriophage dna with the anticancer drug bleomycin produces nicked circular ( form ii ) and linear duplex ( form iii ) dna [ lloyd , r.s. , haidle , c.w . & robberson , d.l . ( 1978 ) biochemistry 17 , 1890-1896 ] . | NA | {
"id": "C0012925",
"name": "circular",
"pos": [
30,
38
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
164,
167
]
} |
although less pure replicase fractions copy a variety of rnas , purer fractions respond better to poliovirus rna than to other viral rnas . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
57,
60
]
} | {
"id": "C0035736",
"name": "viral rnas",
"pos": [
127,
137
]
} |
gel filtration on bio-gel p-2 of 3h-labeled saccharides revealed that nascent chains contained mainly monosaccharides , but some di- or trisaccharides were found with galnac as the linkage sugar . | NA | {
"id": "C0026492",
"name": "monosaccharides",
"pos": [
102,
117
]
} | {
"id": "C0007004",
"name": "sugar",
"pos": [
189,
194
]
} |
the distribution and localization of the oxidase are similar to those of gamma-glutamyl transpeptidase , suggesting that there is a significant relationship among the translocation of intracellular glutathione , the extracellular oxidation of glutathione to glutathione disulfide , and the reactions of the gamma-glutamy... | NA | {
"id": "C0017817",
"name": "glutathione",
"pos": [
198,
209
]
} | {
"id": "C0061516",
"name": "glutathione disulfide",
"pos": [
258,
279
]
} |
conversion of glutathione to glutathione disulfide is followed by utilization of the latter compound by gamma-glutamyl transpeptidase and dipeptidase . | NA | {
"id": "C0017817",
"name": "glutathione",
"pos": [
14,
25
]
} | {
"id": "C0061516",
"name": "glutathione disulfide",
"pos": [
29,
50
]
} |
although intracellular oxidation of glutathione to glutathione disulfide is readily reversed by the action of glutathione reductase , glutathione disulfide formed extracellularly can not be reduced ; | NA | {
"id": "C0017817",
"name": "glutathione",
"pos": [
36,
47
]
} | {
"id": "C0061516",
"name": "glutathione disulfide",
"pos": [
134,
155
]
} |
similarly , the binding of insulin to receptors in 3t3 fibroblasts is increased substantially in the presence of anti-insulin antibody , and the biological activity of subactive concentrations of insulin is enhanced by antibody in these cells . | NA | {
"id": "C0021644",
"name": "anti-insulin antibody",
"pos": [
113,
134
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
219,
227
]
} |
the kinetics of both protein incorporation and nucleoprotein formation suggest that the elongation process is composed of at least two different , possibly sequential , rate-limiting reactions . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
21,
28
]
} | {
"id": "C0028612",
"name": "nucleoprotein",
"pos": [
47,
60
]
} |
the results show that the teratocarcinoma cells do in fact have specific high-affinity ldl receptors which are similar to those reported for fibroblasts and the parenchymal cells of specialized tissues and different from those of phagocytic cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
141,
152
]
} | {
"id": "C0007634",
"name": "the",
"pos": [
157,
160
]
} |
studies with two human c-peptide antisera that differ in their relative immunoreactivity with human c-peptide and proinsulin showed that the two antisera reacted equally with familial hyperproinsulinemia proinsulin , suggesting that it is a partially cleaved proinsulin intermediate . | NA | {
"id": "C0006558",
"name": "c-peptide",
"pos": [
23,
32
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
259,
269
]
} |
these data indicate that familial hyperproinsulinemia proinsulin is normally cleaved at the c-peptide-a-chain linkage site . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
39,
49
]
} | {
"id": "C0006558",
"name": "c-peptide",
"pos": [
92,
101
]
} |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.