text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
a structural abnormality appears to underlie familial hyperproinsulinemia proinsulin , which impairs its cleavage at the b-chain-c-peptide linkage site . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
59,
69
]
} | {
"id": "C0006558",
"name": "c-peptide",
"pos": [
129,
138
]
} |
in the two proteins with gly-100 , the following j sequence is limited to one of the two sets of j segments defined by linked amino acids . | NA | {
"id": "C0017890",
"name": "gly",
"pos": [
25,
28
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
126,
137
]
} |
the absence of detectable antigen in the intestinal epithelium contiguous to the bursal epithelium indicates that the accumulation of viral antigen is a specific property of the bursal epithelium . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
26,
33
]
} | {
"id": "C0003342",
"name": "viral antigen",
"pos": [
134,
147
]
} |
when introduced into a culture of 3t3 or l cells and followed by live-cell microscopy , some of these lymphocytes were observed to crawl on top of , along the edges of , and preferentially beneath the attached fibroblasts . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
43,
47
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
210,
221
]
} |
glycocalicin , a soluble loosely bound membrane glycoprotein of mr 150,000 related to the glycoprotein i system , was also purified . | NA | {
"id": "C0025248",
"name": "membrane",
"pos": [
39,
47
]
} | {
"id": "C0017968",
"name": "glycoprotein",
"pos": [
90,
102
]
} |
both in situ hybridization studies and phenol emulsion reassociation of virus dna to dna from purified spermatozoa localized this viral dna to immature and mature sperm cells . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
78,
81
]
} | {
"id": "C0012939",
"name": "viral dna",
"pos": [
130,
139
]
} |
group differences in body weight were not reliable but group g-l rats gained less weight than the rest during the experiment , whereas group l rats gained more . | NA | {
"id": "C0005911",
"name": "differences",
"pos": [
6,
17
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
82,
88
]
} |
the discriminative stimulus properties of l-alpha-acetylmethadol ( laam ) , its metabolities 1-alpha-acetyl-n-normethadol ( norlaam ) and l-alpha-acetyl-n , n-dinormethadol ( dinorlaam ) , and methadone were evaluated in rats trained to discriminate between saline and morphine in a two-choice discrete-trial avoidance p... | NA | {
"id": "C0025607",
"name": "acetylmethadol",
"pos": [
50,
64
]
} | {
"id": "C0025605",
"name": "methadone",
"pos": [
193,
202
]
} |
the similarity of the drug interactions between methylphenidate or amphetamine and amt or tbz suggest that the doses of methylphenidate and d-amphetamine examined act on similar catecholaminergic pools with the central nervous system to influence drl performance . | NA | {
"id": "C0002658",
"name": "amphetamine",
"pos": [
67,
78
]
} | {
"id": "C0011812",
"name": "d-amphetamine",
"pos": [
140,
153
]
} |
the minimal effect of naloxone and naltrexone on normal body temperature and on pyrogen-induced fever indicates that endogenous opioid peptides are unlikely to act physiologically via stimulation of receptors specifically sensitive to morphine . | NA | {
"id": "C0027358",
"name": "naloxone",
"pos": [
22,
30
]
} | {
"id": "C0027360",
"name": "naltrexone",
"pos": [
35,
45
]
} |
mg2+ activity rose during ontogenesis to a lesser degree than na+ -- k+-stimulated atpase and the reciprocal ratio of these atpase and the reciprocal ratio of these atpase activities , in the given parts of the brain , fell progressively in adult animals to values close to 1 . | NA | {
"id": "C0001479",
"name": "na",
"pos": [
62,
64
]
} | {
"id": "C0001473",
"name": "atpase",
"pos": [
165,
171
]
} |
liver glycogen rose to an even higher level than normal in the trained groups , but muscle glycogen values remained lower , this may be related to the shortness of training and to an accelerated rate of turnover . | NA | {
"id": "C0023902",
"name": "liver glycogen",
"pos": [
0,
14
]
} | {
"id": "C0017911",
"name": "glycogen",
"pos": [
91,
99
]
} |
choline administered into the cerebral ventricles of hemicholinium-3 and triethylcholine-treated cats restored the emotional behaviour with aggression , autonomic and motor phenomena as well as clonic-tonic convulsions to intraventricular carbachol , muscarine , eserine and neostigmine . | NA | {
"id": "C0008405",
"name": "choline",
"pos": [
0,
7
]
} | {
"id": "C0006945",
"name": "carbachol",
"pos": [
239,
248
]
} |
in 679 chest trauma patients , traffic accidents and falls were the main reason for the trauma . | NA | {
"id": "C0039980",
"name": "chest trauma",
"pos": [
7,
19
]
} | {
"id": "C0043251",
"name": "trauma",
"pos": [
88,
94
]
} |
both in the supine and standing positions indomethacin failed to alter the plasma concentrations of noradrenaline , adrenaline or dopamine , while pra was markedly suppressed . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
100,
113
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
116,
126
]
} |
the sizes of the spectra ( delta a385-420 ) produced by prostaglandins were smaller than those produced by various steroids including progesterone , 17-hydroxyprogesterone and 11 beta-hydroxyprogesterone . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
134,
146
]
} | {
"id": "C0020387",
"name": "17-hydroxyprogesterone",
"pos": [
149,
171
]
} |
thus adrenalin was reduced by 77 % , noradrenalin by 86.5 % , in direct proportion with the fall in the blood pressure , of the pulse amplitude and with the slowing-down ( or the arrest ) of the microcirculation . | NA | {
"id": "C0014563",
"name": "adrenalin",
"pos": [
5,
14
]
} | {
"id": "C0028351",
"name": "noradrenalin",
"pos": [
37,
49
]
} |
the authors consider that splenectomy in this category of hepatopathies is an immuno-suppressive therapy that may arrest the evolution towards cirrhosis . | NA | {
"id": "C0023895",
"name": "hepatopathies",
"pos": [
58,
71
]
} | {
"id": "C0023890",
"name": "cirrhosis",
"pos": [
143,
152
]
} |
isolated rabbit lung parenchymal strips contracted to epinephrine ( e ) , norepinephrine ( ne ) , phenylephrine ( pe ) , histamine , carbachol , pgf2alpha , bradykinin and 5-ht . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
54,
65
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
74,
88
]
} |
in groups of rats pretreated with barbiturates for five weeks , no animals were induced to sleep after intracerebroventricular injection of pb , and this finding strongly suggests the decrease in sensitivity of rats to barbiturates . | NA | {
"id": "C0031412",
"name": "pb",
"pos": [
140,
142
]
} | {
"id": "C0004745",
"name": "barbiturates",
"pos": [
219,
231
]
} |
the effect of p-mpea on displacement of specific tritiated 5ht binding to membranes from mouse brain was considerably less than that of p-chlorophenylethylamine ( p-cpea ) , p-methoxytryptamine ( pmt ) and quipazine . | NA | {
"id": "C0036751",
"name": "5ht",
"pos": [
59,
62
]
} | {
"id": "C0000589",
"name": "methoxytryptamine",
"pos": [
176,
193
]
} |
in the stage of collapse adrenaline decreased by 81.4 % and noradrenaline by 62.6 % as compared with the preoperative values . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
25,
35
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
60,
73
]
} |
human ia-like antigens , hla antigens , and the cell surface immunoglobulins igd and igm represented the major con-a-binding proteins on the b cells studied . beta 2-microglobulin was found associated with hla antigens on both leukaemic and non-leukaemic t and b cells . | NA | {
"id": "C0019754",
"name": "human ia-like antigens",
"pos": [
0,
22
]
} | {
"id": "C0019721",
"name": "hla antigens",
"pos": [
206,
218
]
} |
the significant 2 degrees mlc response to autologous cells after sensitization to allogeneic cells may reflect recognition of self antigens and raises the question to what extent genetic similarity between responding and stimulating cells is required in the priming phase to elicit a 2 degrees response to autologous cel... | NA | {
"id": "C3485979",
"name": "allogeneic cells",
"pos": [
82,
98
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
317,
322
]
} |
therefore , the application of rf or clq for the differentiation of the binding induced by ic or antibodies is not useful in this assay system . | NA | {
"id": "C0003313",
"name": "ic",
"pos": [
20,
22
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
97,
107
]
} |
the unaltered distribution of sc and iga in crypt epithelium strongly suggests that the epithelial transport mechanism of secretory iga is normal in coeliac disease . | NA | {
"id": "C0036538",
"name": "sc",
"pos": [
30,
32
]
} | {
"id": "C0020838",
"name": "secretory iga",
"pos": [
122,
135
]
} |
in the peripheral blood only 5 % of the mononuclear cells are pna-positive and we have shown that these cells are monocytes . | NA | {
"id": "C1321301",
"name": "peripheral blood",
"pos": [
7,
23
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
104,
109
]
} |
cefoxitin-resistant strains ( mic greater than or equal to 16 micrograms/ml ) were also resistant to the new cephalosporins bl-s786 and hr-756 as well as to the new cefamycins a , b , cl619-183 , cs-1170 and sq-14359 and to thienamycin . | NA | {
"id": "C0007557",
"name": "cefoxitin",
"pos": [
0,
9
]
} | {
"id": "C0007736",
"name": "cefamycins",
"pos": [
165,
175
]
} |
cefoxitin-resistant strains ( mic greater than or equal to 16 micrograms/ml ) were also resistant to the new cephalosporins bl-s786 and hr-756 as well as to the new cefamycins a , b , cl619-183 , cs-1170 and sq-14359 and to thienamycin . | NA | {
"id": "C3536856",
"name": "cephalosporins",
"pos": [
109,
123
]
} | {
"id": "C0007736",
"name": "cefamycins",
"pos": [
165,
175
]
} |
it has been suggested that the newly discovered endogenous opiate peptides ( called endorphins ) might play a role in the symptoms of schizophrenia . | NA | {
"id": "C0205753",
"name": "endogenous opiate peptides",
"pos": [
48,
74
]
} | {
"id": "C0014242",
"name": "endorphins",
"pos": [
84,
94
]
} |
[ effect of 2 retinoids ( vitamin a analogs ) on human bronchogenic carcinoma in vivo ( nu/nu mouse ) and in vitro ] . | NA | {
"id": "C0035339",
"name": "retinoids",
"pos": [
14,
23
]
} | {
"id": "C0042839",
"name": "vitamin a",
"pos": [
26,
35
]
} |
preliminary indications are that surgical t- and n-stage , type of resection , histological type of tumor as well as degree of tumor dedifferentiation ( central histology review ) are prognostic factors with regard to disease-free interval and survival . | NA | {
"id": "C0027652",
"name": "histological type of tumor",
"pos": [
79,
105
]
} | {
"id": "C0027651",
"name": "tumor",
"pos": [
127,
132
]
} |
under realistic assumptions , the biosynthesis and diffusion through the extracellular matrix of a cell surface protein , such as fibronectin , will lead to spatial patterns of this molecule that could be the basis of the emergent primordia . | NA | {
"id": "C0079323",
"name": "extracellular",
"pos": [
73,
86
]
} | {
"id": "C0016055",
"name": "fibronectin",
"pos": [
130,
141
]
} |
mouse spinal neurons grown in tissue culture were used to study the membrane effects of the benzodiazepine flurazepam and the naturally occurring purine nucleoside inosine , which competes for benzodiazepine receptor sites in the central nervous system . | NA | {
"id": "C0034136",
"name": "purine",
"pos": [
146,
152
]
} | {
"id": "C0021528",
"name": "inosine",
"pos": [
164,
171
]
} |
these findings may correlate with subjective mood changes commonly experienced in the premenstrual phase and in the well-recognized tendency of certain epileptic women to have seizures only at the time of their menses . | NA | {
"id": "C0014544",
"name": "epileptic",
"pos": [
152,
161
]
} | {
"id": "C0036572",
"name": "seizures",
"pos": [
176,
184
]
} |
substances affecting the function of the adrenergic system are the agonists or stimulators , which mimic the effects of endogenous norepinephrine or epinephrine , and antagonists or blockers , which block the receptors and prevent stimulation by the agonists . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
131,
145
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
149,
160
]
} |
autonomic agents used in the treatment of ocular hypertension and glaucoma include pilocarpine , a chilinergic agonist , epinephrine , an adrenergic agonist , and various beta adrenergic blockers or antagonists including propranolol , atenolol and timolol . | NA | {
"id": "C0028840",
"name": "ocular hypertension",
"pos": [
42,
61
]
} | {
"id": "C0017601",
"name": "glaucoma",
"pos": [
66,
74
]
} |
albumin supplementation increased serum albumin ( 4.2 vs. 2.9 gm % ) , plasma volume , cvp ( 15 vs. 9 cm h2o ) , but did not alter red cell volume ( 1,531 vs. 1,519 ml ) . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
0,
7
]
} | {
"id": "C0036773",
"name": "serum",
"pos": [
34,
39
]
} |
although the two complete amino acid mixtures produced similar nitrogen preservation and muscle synthesis in the septic animals , the crystalline amino acid diet containing 50 % branched chain amino acids resulted in the greatest preservation of total liver nitrogen and the highest fractional synthetic rate . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
26,
36
]
} | {
"id": "C0002521",
"name": "branched",
"pos": [
178,
186
]
} |
on the basis of the fraction of collagen bound and its hydroxyproline/proline ratio , it is concluded that the activity resides in the type i collagen component . | NA | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
55,
69
]
} | {
"id": "C0033382",
"name": "proline",
"pos": [
70,
77
]
} |
in the infant the clotting factor levels reflected depression of vitamins k-dependent factors ii , ix , and x and a factor xii level of 40.0 % . | NA | {
"id": "C0005789",
"name": "clotting factor",
"pos": [
18,
33
]
} | {
"id": "C0033706",
"name": "factors ii",
"pos": [
86,
96
]
} |
in the infant the clotting factor levels reflected depression of vitamins k-dependent factors ii , ix , and x and a factor xii level of 40.0 % . | NA | {
"id": "C0005789",
"name": "clotting factor",
"pos": [
18,
33
]
} | {
"id": "C0015491",
"name": "ix",
"pos": [
99,
101
]
} |
the 7- and 12-monosulfates of chenodeoxycholic acid , deoxycholic acid , and cholic acid were prepared by sulfation of the protected bile acids with sulfur trioxide-triethylamine in pyridine overnight and were isolated by precipitation as the p-toluidinium salt after removing the protecting group ( s ) . | NA | {
"id": "C0008024",
"name": "chenodeoxycholic acid",
"pos": [
30,
51
]
} | {
"id": "C0011479",
"name": "deoxycholic acid",
"pos": [
54,
70
]
} |
the ionically combined hapten functioned as an antigenic determinant as do covalently bound haptens when administered to sheep in emulsions with freund 's complete adjuvant . | NA | {
"id": "C0003316",
"name": "antigenic",
"pos": [
47,
56
]
} | {
"id": "C0018593",
"name": "haptens",
"pos": [
92,
99
]
} |
literature data concerning acid hydrolysis of dna during the feulgen procedure are reviewed , with emphasis being made on the dependence of schiff-apurinic acid binding on the fixation technique , the temperature of hydrolysis and acid concentration , the rate of extraction of depolymerized dna fragments , the nucleoti... | NA | {
"id": "C0008546",
"name": "chromatin",
"pos": [
348,
357
]
} | {
"id": "C0028612",
"name": "nucleoprotein",
"pos": [
392,
405
]
} |
the glycogen of the rat liver cells during a first week of the postnatal development is different from that detected in adult liver cells in two aspects : in 3 day old hepatocytes soluble and stable glycogen fractions are equal , while in adult rat liver cells the former makes 80 -- 90 % ; | NA | {
"id": "C0023902",
"name": "glycogen",
"pos": [
4,
12
]
} | {
"id": "C0017911",
"name": "glycogen",
"pos": [
199,
207
]
} |
in the present report , investigations have been carried out to evaluate toxic and therapeutic effects of cyclophosphamide vs its isomer iphosphamide . | NA | {
"id": "C0010583",
"name": "cyclophosphamide",
"pos": [
106,
122
]
} | {
"id": "C0020823",
"name": "iphosphamide",
"pos": [
137,
149
]
} |
it has been observed that iphosphamide is less toxic as compared to cyclophosphamide ( ld50 ip ld50 cp = 1.5 ) ; | NA | {
"id": "C0020823",
"name": "iphosphamide",
"pos": [
26,
38
]
} | {
"id": "C0010583",
"name": "cyclophosphamide",
"pos": [
68,
84
]
} |
in the alcohol condition , there was an initial increase in body sway corresponding to the acute phase of ethanol intoxication . | NA | {
"id": "C0236664",
"name": "alcohol",
"pos": [
7,
14
]
} | {
"id": "C0001969",
"name": "acute",
"pos": [
91,
96
]
} |
to obtain more insight into the problem on the concentration of active androgens in the male organism , the diurnal elimination of testosterone , epitestosterone and estrogens in the urine of male patients with cancer of the lung , urinary bladder , larynx and prostate ( 321 patients ) , in stage ii -- iii , was estima... | NA | {
"id": "C0039601",
"name": "testosterone",
"pos": [
131,
143
]
} | {
"id": "C0014594",
"name": "epitestosterone",
"pos": [
146,
161
]
} |
in all the examined patients irrespective of the tumor process localization a relative or even absolute predominance of epitestosterone over testosterone was evident . | NA | {
"id": "C0014594",
"name": "epitestosterone",
"pos": [
120,
135
]
} | {
"id": "C0039601",
"name": "testosterone",
"pos": [
141,
153
]
} |
the author has studied morphometrically the cell ultrastructure of fibroblastic and smooth muscle human tumors . | NA | {
"id": "C0007634",
"name": "the cell",
"pos": [
40,
48
]
} | {
"id": "C0016030",
"name": "fibroblastic",
"pos": [
67,
79
]
} |
the ultrastructure of biliary canaliculi changed according to the type , observed in intrahepatic cholestasis , makes it mandatory to be careful while using cyclophosphamide in patients with the cholestatic syndrome . | NA | {
"id": "C0008372",
"name": "intrahepatic cholestasis",
"pos": [
85,
109
]
} | {
"id": "C0008370",
"name": "cholestatic",
"pos": [
195,
206
]
} |
as the main source of protein at the time of the patient 's treatment various protein hydrolysates are used . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
22,
29
]
} | {
"id": "C0033631",
"name": "protein hydrolysates",
"pos": [
78,
98
]
} |
the immune antibody in the serum of the propositus reacts with all cells tested except homozygous -d- , cwd- , cd- and rhnull cells . | NA | {
"id": "C0020960",
"name": "immune",
"pos": [
4,
10
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
11,
19
]
} |
antigenic analysis showed that protein emm lacks light chains and the ch1 domain of heavy chains , whereas the antigenic determinants of the gamma 3 fc fragment ( ch2 and ch3 domains ) as well as those of the gamma 3 hinge region were present . | NA | {
"id": "C0003320",
"name": "antigenic",
"pos": [
0,
9
]
} | {
"id": "C0003316",
"name": "antigenic determinants",
"pos": [
111,
133
]
} |
the main changes consisted in the loss of coordination of age cellular protein synthesis and formation of new virus-specific proteins . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
71,
78
]
} | {
"id": "C0034861",
"name": "formation",
"pos": [
93,
102
]
} |
in those patients who responded well to l-dopa the csf hva/g l-dopa was intermediate between that of these two groups . | NA | {
"id": "C0023570",
"name": "l-dopa",
"pos": [
40,
46
]
} | {
"id": "C0013023",
"name": "dopa",
"pos": [
63,
67
]
} |
involvement of the brain by what appeared to be an identical pathological process led to her death , and the orbital tissues were also involved at one stage . | NA | {
"id": "C0030660",
"name": "pathological process",
"pos": [
61,
81
]
} | {
"id": "C0011065",
"name": "death",
"pos": [
93,
98
]
} |
the b ( 12 ) in fresh cow 's milk was found to be largely 5-deoxyadenosyl cobalamin whereas dried milk contained only hydroxocobalamin and a little cyanocobalamin . | NA | {
"id": "C0020316",
"name": "hydroxocobalamin",
"pos": [
118,
134
]
} | {
"id": "C0042845",
"name": "cyanocobalamin",
"pos": [
148,
162
]
} |
in order to investigate a possible competition for intestinal transport between amino acids and monosaccharides in man , iso-osmotic solutions containing ( a ) 100 m-mole glycine 1 . ( -1 ) , ( b ) 100 m-mole glycine and 200 m-mole monosaccharide ( glucose or galactose ) 1 . ( -1 ) , and ( c ) 200 m-mole monosaccharide... | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
80,
91
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
209,
216
]
} |
the nature of the antibody in iso-immune anti-l sera affecting active potassium transport in lk sheep red cells . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
18,
26
]
} | {
"id": "C0020960",
"name": "immune",
"pos": [
34,
40
]
} |
[ presence of serum alpha 1-fetoprotein in 4 cases of primary digestive neoplasms other than hepatoma ] . | NA | {
"id": "C0012243",
"name": "of",
"pos": [
11,
13
]
} | {
"id": "C0023903",
"name": "hepatoma",
"pos": [
93,
101
]
} |
[ study of ventilatory parameters , blood sugar , and plasma free fatty acids in the course of muscular exertion with glucose loading and in hypoxia ] . | NA | {
"id": "C0005802",
"name": "blood sugar",
"pos": [
36,
47
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
118,
125
]
} |
aspartic acid , asparagine , glutamic acid , and glutamine contents of wool and two derived protein fractions . | NA | {
"id": "C0061472",
"name": "glutamic acid",
"pos": [
29,
42
]
} | {
"id": "C0017797",
"name": "glutamine",
"pos": [
49,
58
]
} |
comparison of the labeling of 4-thiouridine and pseudouridine , obtained from an enzymatic digest of the rna , indicates that their biosynthetic precursor is uridine , not cytidine . | NA | {
"id": "C0033846",
"name": "pseudouridine",
"pos": [
48,
61
]
} | {
"id": "C0041984",
"name": "uridine",
"pos": [
158,
165
]
} |
it became evident from these results that in s. marcescens isoleucine-valine biosynthetic enzymes are subject to multivalent repression by three branched-chain amino acids . | NA | {
"id": "C0022192",
"name": "isoleucine",
"pos": [
59,
69
]
} | {
"id": "C0002521",
"name": "branched-chain amino acids",
"pos": [
145,
171
]
} |
it became evident from these results that in s. marcescens isoleucine-valine biosynthetic enzymes are subject to multivalent repression by three branched-chain amino acids . | NA | {
"id": "C0042285",
"name": "valine",
"pos": [
70,
76
]
} | {
"id": "C0002521",
"name": "branched-chain amino acids",
"pos": [
145,
171
]
} |
glycine , alanine , and serine accounted for 75 % of the nh ( 2 ) -terminal amino acids , and glycine appeared most frequently in mature proteins of mycelia . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
10,
17
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
76,
87
]
} |
glycine , alanine , and serine accounted for 75 % of the nh ( 2 ) -terminal amino acids , and glycine appeared most frequently in mature proteins of mycelia . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
76,
87
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
94,
101
]
} |
the phosphoramides are an exception in that they do not gain access to the cholinesterase of the central nervous system in vivo and consequently atropine is a more effective antidote for them than for organophosphorus compounds . | NA | {
"id": "C3494394",
"name": "phosphoramides",
"pos": [
4,
18
]
} | {
"id": "C0029254",
"name": "organophosphorus compounds",
"pos": [
201,
227
]
} |
for mosquito coils , allethrin and prothrin were superior to the natural pyrethrins in both kill and knock-down effects . | NA | {
"id": "C0002119",
"name": "allethrin",
"pos": [
21,
30
]
} | {
"id": "C0034245",
"name": "pyrethrins",
"pos": [
73,
83
]
} |
extracellular enterotoxin was synthesized until the cells entered the stationary phase during which cell-bound toxin was not detected . | NA | {
"id": "C0014372",
"name": "enterotoxin",
"pos": [
14,
25
]
} | {
"id": "C0040549",
"name": "toxin",
"pos": [
111,
116
]
} |
similarly , inhibition of free glycine and free leucine absorption by isoleucine was not accompanied by any remarkable alteration of absorption rates of the constituent amino acids of glycylleucine . | NA | {
"id": "C0017890",
"name": "glycine",
"pos": [
31,
38
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
169,
180
]
} |
metabolic turnover studies of igg , iga , igm , and albumin were conducted in seven patients with the wiskott-aldrich syndrome using purified radioiodinated proteins . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
52,
59
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
157,
165
]
} |
the survival of each of the proteins studied was significantly shortened with a half-time of 7.5 days for igg ( normal 22.9 +/-4 sd ) , 3.0 days for iga ( normal 5.8 +/-1 ) , 5.0 days for igm ( normal 10.1 +/-2.1 ) , and 8.6 days for albumin ( normal 17 , range 13-20 ) ; | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
28,
36
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
234,
241
]
} |
normal individuals , individuals with sex-linked and acquired agammaglobulinemia , selective iga deficiency , cellular immune deficiencies , and individuals with chronic lymphatic leukemia ( cll ) were studied . | NA | {
"id": "C0009447",
"name": "acquired agammaglobulinemia",
"pos": [
53,
80
]
} | {
"id": "C0021051",
"name": "immune deficiencies",
"pos": [
119,
138
]
} |
uptake , metabolism and excretion of desmethylimipramine and its metabolites in the isolated perfused rat liver . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
9,
19
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
24,
33
]
} |
haemoglobin osu-christiansborg : a new beta-chain variant of haemoglobin a ( beta52 ( d3 ) aspartic acid leads to asparagine ) in combination with haemoglobin s . | NA | {
"id": "C0019016",
"name": "a",
"pos": [
1,
2
]
} | {
"id": "C0019046",
"name": "haemoglobin",
"pos": [
147,
158
]
} |
[ changes in the adrenaline , noradrenaline , serotonin and histamine content of the blood and organs of rats during different degrees of skin thermal burn ] . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
17,
27
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
30,
43
]
} |
deoxycholic acid caused consistent secretion at 3 mm concentrations , whereas chenodeoxycholic acid did not induce secretion until the concentration was 5 mm . | NA | {
"id": "C0011479",
"name": "deoxycholic acid",
"pos": [
0,
16
]
} | {
"id": "C0008024",
"name": "chenodeoxycholic",
"pos": [
78,
94
]
} |
the straight-chain fatty acid , 11-eicosanoic acid ( 10 ( -7 ) m ) , was inactive on basal activity or on the response to vasopressin . | NA | {
"id": "C0015684",
"name": "fatty acid",
"pos": [
19,
29
]
} | {
"id": "C0013724",
"name": "eicosanoic",
"pos": [
35,
45
]
} |
the increase in the lipid content of plaque elastic preparations was mainly due to large increases in cholesterol , over 80 % of which was cholesteryl ester . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
102,
113
]
} | {
"id": "C0008387",
"name": "cholesteryl ester",
"pos": [
139,
156
]
} |
a net uptake of lactate , pyruvate , and nine amino acids was observed , with alanine accounting for half of the total splanchnic-amino acid extraction . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
78,
85
]
} | {
"id": "C0002520",
"name": "amino acid",
"pos": [
130,
140
]
} |
during the pre-stimulation control periods adrenaline constituted 66 % of the total catecholamine present in adrenal venous blood and noradrenaline 34 % . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
43,
53
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
134,
147
]
} |
the reversal potential of inhibitory junctional potentials ( i.j.p.s ) was measured shortly after replacing cl ( - ) by foreign anions : br ( - ) , no ( 3 ) ( - ) , i ( - ) and cns ( - ) . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
128,
134
]
} | {
"id": "C0021966",
"name": "i",
"pos": [
165,
166
]
} |
studies on the uptake of ( i- 14 c ) ascorbic acid and ( i- 14 c ) -dehydroascorbic acid by platelets of guinea pigs . | NA | {
"id": "C0003968",
"name": "ascorbic acid",
"pos": [
37,
50
]
} | {
"id": "C0011177",
"name": "dehydroascorbic",
"pos": [
68,
83
]
} |
urinary excretion of testosterone and epitestosterone in men , women and children , in health and disease . | NA | {
"id": "C0039601",
"name": "testosterone",
"pos": [
21,
33
]
} | {
"id": "C0014594",
"name": "epitestosterone",
"pos": [
38,
53
]
} |
these antisera were cytotoxc for a large percentage of antibody-forming cells and killed approximately 30 % of spleen cells the other two anti-bursa sera were somewhat less potent but showed similar specificity . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
6,
14
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
55,
63
]
} |
all precapillary vessels in the germfree rats were markedly hyporeactive to the catecholamines , epinephrine and norepinephrine , as compared to similar vessels of conventional rats . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
97,
108
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
113,
127
]
} |
the conclusion drawn from these observations is that the circulating lymphocyte pool of an individual consists of a greater proportion of cells reactive to h alloantigens of other members of the same species than to the xenogeneic cellular antigens of members of other species and that this large number of cells is not ... | NA | {
"id": "C0003333",
"name": "xenogeneic",
"pos": [
220,
230
]
} | {
"id": "C0003320",
"name": "antigens",
"pos": [
400,
408
]
} |
ehrlich ascites tumor cells mask the receptor rapidly , primary chick fibroblasts minimally , and embryonic chick erythrocytes not at all . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
22,
27
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
70,
81
]
} |
functionally , the molecule is the precursor of the activator of prekallikrein ( pre-pka ) and evidence is presented that it is identical with hageman factor ( clotting factor xii ) . | NA | {
"id": "C0015527",
"name": "activator",
"pos": [
52,
61
]
} | {
"id": "C0015525",
"name": "clotting factor xii",
"pos": [
160,
179
]
} |
utilization of differentiation of antibodies to shigella organisms according to the immunoglobulin class in the serological diagnostics of dysentery and in study of its epidemiology . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
34,
44
]
} | {
"id": "C0021017",
"name": "immunoglobulin class",
"pos": [
84,
104
]
} |
the results show that ( i ) at room temperature the levels of excretion are lower in italico than in wistar rats in spite of the equal amine contents of the adrenal medullae , ( ii ) the first exposure to cold causes a large increase in the urinary excretion and a decrease of adrenaline and noradrenaline content of the... | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
277,
287
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
292,
305
]
} |
the effect of adrenaline and noradrenaline on the blood flow , electrical conductance and external secretion of the pancreas . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
14,
24
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
29,
42
]
} |
adrenaline and noradrenaline cause a biphasic change in the transverse electrical conductance across the cat pancreas . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
0,
10
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
15,
28
]
} |
most of the free fatty acid uptake was the result of fatty acid transfer from low density lipoproteins to the cell , not from irreversible incorporation of the intact free fatty acid-low density lipoprotein complex . | NA | {
"id": "C0015684",
"name": "fatty acid",
"pos": [
17,
27
]
} | {
"id": "C0015688",
"name": "free fatty acid",
"pos": [
167,
182
]
} |
fatty acid uptake increased as the ratio of free fatty acid to low density lipoprotein was raised . | NA | {
"id": "C0015684",
"name": "fatty acid",
"pos": [
0,
10
]
} | {
"id": "C0015688",
"name": "free",
"pos": [
44,
48
]
} |
the mechanism of free fatty acid utilization by the ehrlich cell is similar when either low density lipoprotein or serum albumin serves as the fatty acid carrier . | NA | {
"id": "C0015688",
"name": "free fatty acid",
"pos": [
17,
32
]
} | {
"id": "C0015684",
"name": "fatty",
"pos": [
143,
148
]
} |
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