text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
thus , carbohydrate feeding did not result in altered uptakes of free fatty acids or preferential secretion of triglycerides containing endogenously synthesized fatty acid . | NA | {
"id": "C0015688",
"name": "free fatty acids",
"pos": [
65,
81
]
} | {
"id": "C0015684",
"name": "fatty acid",
"pos": [
161,
171
]
} |
artifacts produced by boron trifluoride methanolysis of a synthetic lecithin containing cyclopropane fatty acids ( 1-2-dihydrosterculoyl-3-sn-phosphatidylcholine ) . | NA | {
"id": "C0031617",
"name": "lecithin",
"pos": [
68,
76
]
} | {
"id": "C1959616",
"name": "phosphatidylcholine",
"pos": [
142,
161
]
} |
[ study of the role of isoantigens and isoantibodies in the formation of false positive serologic reactions with echinococcus antigen ] . | NA | {
"id": "C0022145",
"name": "isoantigens",
"pos": [
23,
34
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
126,
133
]
} |
[ the influence of an adrenergic potentiator on the fate of exogenously administered norepinephrine and epinephrine ] . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
85,
99
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
104,
115
]
} |
differential susceptibility to acute cyto-intoxication by amd , or other inhibitors of rna synthesis ( daunomycin or nogalamycin ) , among different types of cultured cells is analogous to that observed in vivo in certain tissues and tumors , and can not be accounted for by differences in the effect of amd on rna , dna... | NA | {
"id": "C0011015",
"name": "daunomycin",
"pos": [
103,
113
]
} | {
"id": "C0028261",
"name": "nogalamycin",
"pos": [
117,
128
]
} |
an antiserum to flagellar axonemes from sperm of arbacia punctulata contains antibodies which react both with intact flagellar outer fibers and with purified tubulin from the outer fibers . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
3,
12
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
77,
87
]
} |
under these conditions most of the hybridizing mrna and nrna react at values of d ( o ) t ( dna concentration multiplied by time ) expected for rna transcribed from the nonrepeated or rarely repeated fraction of the genome . | NA | {
"id": "C0035696",
"name": "mrna",
"pos": [
47,
51
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
144,
147
]
} |
under these conditions most of the hybridizing mrna and nrna react at values of d ( o ) t ( dna concentration multiplied by time ) expected for rna transcribed from the nonrepeated or rarely repeated fraction of the genome . | NA | {
"id": "C0035700",
"name": "nrna",
"pos": [
56,
60
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
144,
147
]
} |
reversible breakdown of the blood-brain barrier is produced by a class of electrolytes and nonelectrolytes which have little or no lipid solubility but which difler in chemical and ionic properties . | NA | {
"id": "C0013832",
"name": "electrolytes",
"pos": [
74,
86
]
} | {
"id": "C0022023",
"name": "ionic",
"pos": [
181,
186
]
} |
[ studies on cardiovascular drugs . 3. absorption , distribution , excretion and metabolism of 8- ( ( 1,4-benzodioxane-2-yl ) methyl ) -3-oxo-1-thia-4,8-diazaspiro ( 4,5 ) decane maleate ( y-3506 ) ] . | NA | {
"id": "C0221102",
"name": "excretion",
"pos": [
67,
76
]
} | {
"id": "C0025519",
"name": "metabolism",
"pos": [
81,
91
]
} |
[ action on pathogenic staphylococci of a semisynthetic penicillin produced in an antibiotic factory in jassy . i. action of methicillin ] . | NA | {
"id": "C0030842",
"name": "penicillin",
"pos": [
56,
66
]
} | {
"id": "C0025643",
"name": "methicillin",
"pos": [
125,
136
]
} |
the mechanism of binding of immune complexes to macrophages was investigated using purified antibody and haptens of different valences . | NA | {
"id": "C0003313",
"name": "immune complexes",
"pos": [
28,
44
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
92,
100
]
} |
effects of diphenhydramine and dimenhydrinate on vestibular neuronal activity of cat : a search for the locus of their antimotion sickness action . | NA | {
"id": "C0012522",
"name": "diphenhydramine",
"pos": [
11,
26
]
} | {
"id": "C0012381",
"name": "dimenhydrinate",
"pos": [
31,
45
]
} |
from these observations it is concluded that synthesis of microtubular precursor protein is mediated by the mature centriole and that this protein is packaged into many condensation forms in order to allow the rapid assembly of a large number of centrioles in a brief period of time . | NA | {
"id": "C0033665",
"name": "precursor protein",
"pos": [
71,
88
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
139,
146
]
} |
after correction for ribosomal and intracisternal proteins , the latter value was lowered to 4.7 mg of membrane protein per m ( 2 ) . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
50,
58
]
} | {
"id": "C0025252",
"name": "membrane",
"pos": [
103,
111
]
} |
starch isolated from the fungi hericium ramosum and hericium coralloides differs from that of higher plants in that it consists only of short-chain amylose molecules ( 32 to 45 glucose units long ) . | NA | {
"id": "C0038179",
"name": "starch",
"pos": [
0,
6
]
} | {
"id": "C0002732",
"name": "amylose",
"pos": [
148,
155
]
} |
[ growth and weight of children in the 1st year of life related to their birth weight ] . | NA | {
"id": "C0005910",
"name": "weight",
"pos": [
13,
19
]
} | {
"id": "C0005612",
"name": "birth",
"pos": [
73,
78
]
} |
we studied this apparent difference by administering ethanol to appropriate subjects and determining blood alcohol concentrations at intervals . | NA | {
"id": "C0001962",
"name": "ethanol",
"pos": [
53,
60
]
} | {
"id": "C0684262",
"name": "blood alcohol",
"pos": [
101,
114
]
} |
further , in both instances the immunosuppressive effect is mediated by antigen-antibody complexes and not by free antibody alone . | NA | {
"id": "C0003313",
"name": "antigen-antibody",
"pos": [
72,
88
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
115,
123
]
} |
presensitized lymphocytes were exposed to antigen-antibody complexes , washed , and then allowed to interact with fresh tumor cells ( not antibody treated ) . | NA | {
"id": "C0003313",
"name": "antigen-antibody complexes",
"pos": [
42,
68
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
138,
146
]
} |
ribonucleic acid ( rna ) from encephalomyocarditis ( emc ) virus stimulates the incorporation of amino acids into protein in cell-free protein-synthetic systems derived from krebs mouse ascites tumor cells and chick embryo fibroblasts ; | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
200,
205
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
223,
234
]
} |
[ thin layer silica gel chromatography of penicillins . semi-quantitative method for the determination of benzylpenicillin in carbenicillin preparations ] . | NA | {
"id": "C0030827",
"name": "benzylpenicillin",
"pos": [
106,
122
]
} | {
"id": "C0006976",
"name": "carbenicillin",
"pos": [
126,
139
]
} |
[ effect of adrenaline and noradrenaline on the volume rate of cerebral circulation and oxygen tension in brain tissue ] . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
12,
22
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
27,
40
]
} |
the physical and enzymatic properties of these two proteins were found to closely resemble the properties reported in the literature for the subunits of fraction i protein . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
51,
59
]
} | {
"id": "C0599220",
"name": "subunits",
"pos": [
141,
149
]
} |
a new substituted nitroimidazole , nitrimidazine ( naxogin ) , is compared with the established drug , metronidazole ( flagyl ) , for the treatment of vaginal trichomoniasis in a randomized double-blind trial . | NA | {
"id": "C0028179",
"name": "nitroimidazole",
"pos": [
18,
32
]
} | {
"id": "C0028095",
"name": "nitrimidazine",
"pos": [
35,
48
]
} |
a new substituted nitroimidazole , nitrimidazine ( naxogin ) , is compared with the established drug , metronidazole ( flagyl ) , for the treatment of vaginal trichomoniasis in a randomized double-blind trial . | NA | {
"id": "C0028179",
"name": "nitroimidazole",
"pos": [
18,
32
]
} | {
"id": "C0025872",
"name": "metronidazole",
"pos": [
103,
116
]
} |
the effect of prolonged consumption of beer , wine and ethanol on the myocardium of the mouse . | NA | {
"id": "C0004922",
"name": "beer",
"pos": [
39,
43
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
55,
62
]
} |
the effect of prolonged consumption of beer , wine and ethanol on the myocardium of the mouse . | NA | {
"id": "C0043188",
"name": "wine",
"pos": [
46,
50
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
55,
62
]
} |
[ selection of drugs in ocular infections antibiotic therapy in corneal ulcer caused by p. aeruginosa ] . | NA | {
"id": "C0015403",
"name": "ocular infections",
"pos": [
24,
41
]
} | {
"id": "C0010043",
"name": "corneal ulcer",
"pos": [
64,
77
]
} |
acetyl-l-carnitine , palmitoyl-l-carnitine , glutamate and 2-oxoglutarate are oxidized at rates similar to those obtained with mammalian mitochondria , though lower than those obtained with the two prime substrates . | NA | {
"id": "C0001040",
"name": "acetyl-l-carnitine",
"pos": [
0,
18
]
} | {
"id": "C0007258",
"name": "carnitine",
"pos": [
33,
42
]
} |
the major components in the extract were two similar lipoproteins , of molecular weight about 400000 , containing 21 % lipid , some two-thirds of which was phospholipid , and about 0.5 % protein phosphorus . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
53,
65
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
163,
168
]
} |
an evaluation of the contribution of glc techniques for the estimation of progesterone and pregnane steroids . | NA | {
"id": "C0033006",
"name": "pregnane",
"pos": [
91,
99
]
} | {
"id": "C0038317",
"name": "steroids",
"pos": [
100,
108
]
} |
an integrated procedure for the rapid diagnosis of biliary obstruction , portal hypertension and liver disease of uncertain etiology . | NA | {
"id": "C0020541",
"name": "portal",
"pos": [
73,
79
]
} | {
"id": "C0023895",
"name": "liver disease of",
"pos": [
97,
113
]
} |
these sheets , used primarily in inexpensive cigars , often contain diatomaceous earth , which exists in part in the silica mineral form cristobalite , a known fibrogen . | NA | {
"id": "C0022683",
"name": "diatomaceous earth",
"pos": [
68,
86
]
} | {
"id": "C0037098",
"name": "cristobalite",
"pos": [
137,
149
]
} |
these sheets , used primarily in inexpensive cigars , often contain diatomaceous earth , which exists in part in the silica mineral form cristobalite , a known fibrogen . | NA | {
"id": "C0026162",
"name": "mineral",
"pos": [
124,
131
]
} | {
"id": "C0037098",
"name": "cristobalite",
"pos": [
137,
149
]
} |
linear synthesis of viral rna persists for 5 to 6 hours at 34 degrees c in infected monolayers of chick embryo cells treated with cycloheximide and actinomycin d to block synthesis of protein and cell-specific rna . | NA | {
"id": "C0035736",
"name": "viral rna",
"pos": [
20,
29
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
210,
213
]
} |
[ 1,2- ( 3 ) h ( 2 ) ] cholecalciferol has been synthesized with a specific radioactivity of 508mci/mmol by using tristriphenylphosphinerhodium chloride , the homogeneous hydrogen catalyst . | NA | {
"id": "C0011744",
"name": "h ( 2",
"pos": [
13,
18
]
} | {
"id": "C0020275",
"name": "hydrogen",
"pos": [
171,
179
]
} |
glucosamine synthetase ( l-glutamine-d-fructose 6-phosphate aminotransferase , ec 2.6.1.16 ) was purified about 300-fold from rat liver by two techniques . | NA | {
"id": "C0017723",
"name": "glucosamine synthetase",
"pos": [
0,
22
]
} | {
"id": "C0002594",
"name": "aminotransferase",
"pos": [
60,
76
]
} |
the nature of the feedback inhibition of hexosamine biosynthesis on rat liver glucosamine synthetase ( l-glutamine-d-fructose 6-phosphate aminotransferase , ec 2.6.1.16 ) by udp-n-acetylglucosamine was investigated in detail . | NA | {
"id": "C0017723",
"name": "glucosamine synthetase",
"pos": [
78,
100
]
} | {
"id": "C0002594",
"name": "aminotransferase",
"pos": [
138,
154
]
} |
the binding of substrates and effectors to glucosamine synthetase ( l-glutamine-d-fructose 6-phosphate aminotransferase , ec 2.6.1.16 ) was studied by using the ligand to alter the denaturation rate of the enzyme . | NA | {
"id": "C0017723",
"name": "glucosamine synthetase",
"pos": [
43,
65
]
} | {
"id": "C0002594",
"name": "aminotransferase",
"pos": [
103,
119
]
} |
in the rats there was a considerable increase in the catabolic rate of albumin which was not related to urinary protein loss . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
71,
78
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
112,
119
]
} |
isotope dilution determinations and other studies of cytidine diphosphate choline , cytidine diphosphate ethanolamine , deoxycytidine diphosphate choline , and deoxycytidine diphosphate ethanolamine in liver and liver tumors . | NA | {
"id": "C0010725",
"name": "cytidine diphosphate",
"pos": [
53,
73
]
} | {
"id": "C0008405",
"name": "choline",
"pos": [
146,
153
]
} |
membrane-limited structures , resembling virus envelope precursors previously shown to form during the interruption of poxvirus assembly by rifampin , were now observed by electron microscopy in vaccinia-infected hela cells treated with a series of rifamycin derivatives . | NA | {
"id": "C0035608",
"name": "rifampin",
"pos": [
140,
148
]
} | {
"id": "C0035609",
"name": "rifamycin",
"pos": [
249,
258
]
} |
a vaccinia mutant selected only for resistance to rifampin was also resistant to the effect on morphogenesis produced by all of the rifamycin derivatives . | NA | {
"id": "C0035608",
"name": "rifampin",
"pos": [
50,
58
]
} | {
"id": "C0035609",
"name": "rifamycin",
"pos": [
132,
141
]
} |
prostaglandins e ( 1 ) , e ( 2 ) , f ( 2alpha ) and a prostaglandin a were identified using solvent partition , column and thin-layer chromatography and bioassay techniques.3 . | NA | {
"id": "C0033559",
"name": "prostaglandins e",
"pos": [
0,
16
]
} | {
"id": "C0033554",
"name": "prostaglandin",
"pos": [
54,
67
]
} |
adrenaline , noradrenaline , isoprenaline , tyramine , phentolamine , pronethalol , histamine and acetylcholine were each tested for their ability to prevent cocaine from causing supersensitivity to catecholamines in cat spleen strips in vitro . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
0,
10
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
13,
26
]
} |
adrenaline , noradrenaline , isoprenaline , tyramine , phentolamine , pronethalol , histamine and acetylcholine were each tested for their ability to prevent cocaine from causing supersensitivity to catecholamines in cat spleen strips in vitro . | NA | {
"id": "C0022245",
"name": "isoprenaline",
"pos": [
29,
41
]
} | {
"id": "C0007412",
"name": "catecholamines",
"pos": [
199,
213
]
} |
[ a possibility for identification of sugars from the smallest amounts of glycosides or from sugar mixtures ] . | NA | {
"id": "C0017977",
"name": "glycosides",
"pos": [
74,
84
]
} | {
"id": "C0007004",
"name": "sugar",
"pos": [
93,
98
]
} |
our interpretation of these data is that chylomicrons are probably derived from intestinal lipoprotein particles by addition of triglyceride . | NA | {
"id": "C0008731",
"name": "chylomicrons",
"pos": [
41,
53
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
91,
102
]
} |
in contrast , clotting , tame esterase , and kinin-forming activities were inhibited after gel filtration chromatography of an incubation mixture of these activities and partially purified c1 inactivator ( c1 esterase inhibitor ) . | NA | {
"id": "C0540301",
"name": "c1",
"pos": [
189,
191
]
} | {
"id": "C0009500",
"name": "c1 esterase inhibitor",
"pos": [
206,
227
]
} |
15 min after oral glucose , the concentration of the proinsulin-like component was unchanged and its percentage of the total immunoreactive insulin decreased with the acute release of the insulin component . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
53,
63
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
188,
195
]
} |
by 2 hr after oral glucose , the concentration of the proinsulin-like component increased and the insulin component concentration decreased so that the percentage of the proinsulin-like component was essentially the same as in the basal state . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
57,
64
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
170,
180
]
} |
in five patients with islet cell tumors and fasting hypoglycemia , basal proinsulin-like component ranged from 26 to 79 % of the total immunoreactive insulin . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
73,
83
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
150,
157
]
} |
acute stimulation with glucose , tolbutamide , leucine , and streptozotocin mainly released the insulin component resulting in a fall in the per cent proinsulin-like component with a subsequent increase in percentage of this component as the total insulin concentration returns towards basal levels . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
96,
103
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
150,
160
]
} |
these studies suggest that the mechanisms regulating the release of the proinsulin-like and of the insulin components are different . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
72,
82
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
99,
106
]
} |
since both vitamin d ( 3 ) and its 25-hydroxy metabolite are lipid-soluble sterol derivatives , the finding that these compounds do not circulate in association with the known plasma lipoproteins provides presumptive evidence for the existence of a specific transport protein of d > 1.21 . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
61,
66
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
183,
195
]
} |
the protein has an apparent size slightly smaller than plasma albumin ( approximate mol wt 50,000-60,000 ) and an electrophoretic mobility very slightly greater than that of albumin . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
4,
11
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
174,
181
]
} |
if glucagon plays a hormonal role in the regulation of gluconeogenesis from endogenous amino acids , its secretion might be stimulated by an increase in the concentration of alanine , which has recently been identified as a principal gluconeogenic precursor . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
87,
98
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
174,
181
]
} |
excretion and metabolism of a nonsteroidal antiinflammatory agent , 4-hydroxy-2-methyl-2h-1,2-benzothiazine-3-carboxanilide 1,1-dioxide , in rat , dog , monkey , and man . | NA | {
"id": "C0221102",
"name": "excretion",
"pos": [
0,
9
]
} | {
"id": "C0025519",
"name": "metabolism",
"pos": [
14,
24
]
} |
a method is described for measuring the porportion of a specific messenger rna in the total rna extracted from pulse-labelled cells . | NA | {
"id": "C0035696",
"name": "messenger rna",
"pos": [
65,
78
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
92,
95
]
} |
the activities in rat tissues of 3-oxo acid coa-transferase ( the first enzyme involved in acetoacetate utilization ) were found to be highest in kidney and heart . | NA | {
"id": "C0022618",
"name": "oxo acid",
"pos": [
35,
43
]
} | {
"id": "C0000988",
"name": "acetoacetate",
"pos": [
91,
103
]
} |
several types of peroxide compound , differing in available oxidizing equivalents and in reactivity with cytochrome c , seem to be formed by stoicheiometric amounts of hydrogen peroxide . | NA | {
"id": "C0031180",
"name": "peroxide",
"pos": [
17,
25
]
} | {
"id": "C0020281",
"name": "hydrogen peroxide",
"pos": [
168,
185
]
} |
[ role of cholinergic receptor in the control of the metabolism of macroenergetic phosphates of the heart . nicotinic receptor ] . | NA | {
"id": "C0034792",
"name": "cholinergic receptor",
"pos": [
10,
30
]
} | {
"id": "C0034830",
"name": "nicotinic receptor",
"pos": [
108,
126
]
} |
under conditions when gluconeogenesis was markedly inhibited there were no changes in the degree of phosphorylation of hepatic adenine nucleotides , but free [ nad ( + ) ] / [ nadh ] ratios fell in both cytosol and mitochondrial compartments of the liver cell . | NA | {
"id": "C0001413",
"name": "adenine nucleotides",
"pos": [
127,
146
]
} | {
"id": "C0027270",
"name": "nad",
"pos": [
176,
179
]
} |
compound ra233 ( 50mum ) increased the effectiveness of both adenosine and 2-chloroadenosine as inhibitors of aggregation by 70-100-fold , and in the presence of compound ra233 both adenosine and 2-chloroadenosine stimulated the incorporation of radioactivity into 3':5'-cyclic amp ; | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
61,
70
]
} | {
"id": "C0000275",
"name": "2-chloroadenosine",
"pos": [
196,
213
]
} |
the results are interpreted as indicating that adenosine , 2-chloroadenosine , isoprenaline , prostaglandin e ( 1 ) and drugs that inhibit platelet 3':5'-cyclic amp phosphodiesterase all inhibit aggregation by a common mechanism involving intracellular 3':5'-cyclic amp . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
47,
56
]
} | {
"id": "C0000275",
"name": "2-chloroadenosine",
"pos": [
59,
76
]
} |
the electrostatic interaction of chondroitin sulphate and the chondroitin sulphate-proteoglycan with collagen was studied by chromatography of the glycosaminoglycan and the proteoglycan on a collagen gel . | NA | {
"id": "C0033689",
"name": "chondroitin",
"pos": [
33,
44
]
} | {
"id": "C0033692",
"name": "proteoglycan",
"pos": [
173,
185
]
} |
the anionic polymers in the cell wall of bacillus subtilis var . niger grown in phosphorus-limiting environments supplemented with increasing concentrations of sodium chloride . | NA | {
"id": "C0003075",
"name": "anionic",
"pos": [
4,
11
]
} | {
"id": "C0008203",
"name": "chloride",
"pos": [
167,
175
]
} |
[ role of cholinergic receptor in the control of macroenergetic phosphate metabolism in rats . muscarinic receptor ] . | NA | {
"id": "C0034792",
"name": "cholinergic receptor",
"pos": [
10,
30
]
} | {
"id": "C0034826",
"name": "muscarinic receptor",
"pos": [
95,
114
]
} |
methylcobalamin as a substrate at a separate site on escherichia coli b n 5 -methyltetrahydrofolate-homocysteine cobalamin methyltransferase . | NA | {
"id": "C0065844",
"name": "substrate",
"pos": [
21,
30
]
} | {
"id": "C0042845",
"name": "cobalamin",
"pos": [
113,
122
]
} |
three criteria were used to define the characteristics of the rrna species : ( i ) the time required at 37 degrees c to synthesize 16s and 23s rrna chains de novo in growing cultures ; | NA | {
"id": "C0035701",
"name": "rrna",
"pos": [
62,
66
]
} | {
"id": "C0035704",
"name": "23s rrna",
"pos": [
139,
147
]
} |
a study was made of the kinetics of labelling of the stable ribonucleic acids ( rrna+trna ) and the unstable mrna fraction in cultures of escherichia coli m.r.e.600 , inhibited by the addition of 0.1g of rifampicin/l . | NA | {
"id": "C0035668",
"name": "ribonucleic acids",
"pos": [
60,
77
]
} | {
"id": "C0035701",
"name": "rrna",
"pos": [
80,
84
]
} |
the kinetics of labelling of rna in inhibited cultures indicated that the clapsed time from the addition of rifampicin to the point at which radioactivity no longer enters the total cellular ribonucleic acids is a measure of the time required to polymerize a molecule of rrna . | NA | {
"id": "C0035668",
"name": "ribonucleic acids",
"pos": [
191,
208
]
} | {
"id": "C0035701",
"name": "rrna",
"pos": [
271,
275
]
} |
nevertheless the need for more data is emphasized by the virtual certainty that rubella vaccine virus transmission did occur in the subject on the isolation ward , plus the high probability that the infection observed in the family group setting also represented transmission of rubella vaccine virus . | NA | {
"id": "C0035924",
"name": "rubella",
"pos": [
80,
87
]
} | {
"id": "C0035923",
"name": "rubella",
"pos": [
279,
286
]
} |
a light microscopic method for the differentiation of noradrenaline- and adrenaline-producing cells of the rat adrenal medulla . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
54,
67
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
73,
83
]
} |
this could indicate that the intracellular concentration of amino acids or aminoacyl-trna limits the rate of protein synthesis and that the increased incorporation results from a rise to a higher but still suboptimum concentration . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
60,
71
]
} | {
"id": "C0035714",
"name": "aminoacyl-trna",
"pos": [
75,
89
]
} |
they are very similar to that of the total membrane proteins but significantly different from that of the chromogranins , the soluble proteins of chromaffin granules . | NA | {
"id": "C0025252",
"name": "membrane proteins",
"pos": [
43,
60
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
134,
142
]
} |
the limiting component appears to be the non-haem-iron-containing protein ( also called fraction ii , iron protein , azoferredoxin ) , which is equivalent to the enhancement factor for nitrogenase activity present in extracts of nitrogenaseless mutant 22r1 . | NA | {
"id": "C0018974",
"name": "haem",
"pos": [
45,
49
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
107,
114
]
} |
approximate relative amounts of the different glycosaminoglycans were : chondroitin sulphate 60 % , chondroitin 2 % , hyaluronic acid 4 % , dermatan sulphate 1 % , heparan sulphate 15 % and keratan sulphate 18 % . | NA | {
"id": "C0017973",
"name": "glycosaminoglycans",
"pos": [
46,
64
]
} | {
"id": "C0008454",
"name": "chondroitin",
"pos": [
100,
111
]
} |
approximate relative amounts of the different glycosaminoglycans were : chondroitin sulphate 60 % , chondroitin 2 % , hyaluronic acid 4 % , dermatan sulphate 1 % , heparan sulphate 15 % and keratan sulphate 18 % . | NA | {
"id": "C0017973",
"name": "glycosaminoglycans",
"pos": [
46,
64
]
} | {
"id": "C0019143",
"name": "heparan sulphate",
"pos": [
164,
180
]
} |
approximate relative amounts of the different glycosaminoglycans were : chondroitin sulphate 60 % , chondroitin 2 % , hyaluronic acid 4 % , dermatan sulphate 1 % , heparan sulphate 15 % and keratan sulphate 18 % . | NA | {
"id": "C0008466",
"name": "chondroitin sulphate",
"pos": [
72,
92
]
} | {
"id": "C0008454",
"name": "chondroitin",
"pos": [
100,
111
]
} |
approximate relative amounts of the different glycosaminoglycans were : chondroitin sulphate 60 % , chondroitin 2 % , hyaluronic acid 4 % , dermatan sulphate 1 % , heparan sulphate 15 % and keratan sulphate 18 % . | NA | {
"id": "C0008454",
"name": "chondroitin",
"pos": [
72,
83
]
} | {
"id": "C0011602",
"name": "dermatan sulphate",
"pos": [
140,
157
]
} |
distribution of acetylcholinesterase and butyrylcholinesterase in the myenteric plexus and longitudinal muscle of the guinea-pig intestine . | NA | {
"id": "C0001044",
"name": "acetylcholinesterase",
"pos": [
16,
36
]
} | {
"id": "C0008429",
"name": "butyrylcholinesterase",
"pos": [
41,
62
]
} |
the fine structure of bombyx mori silk fibroin was investigated by electron microscopy and x-ray diffraction techniques . | NA | {
"id": "C0074529",
"name": "silk",
"pos": [
34,
38
]
} | {
"id": "C0016042",
"name": "fibroin",
"pos": [
39,
46
]
} |
it is concluded that the crystalline material in b. mori silk fibroin is in the form of ribbon-like filaments of considerable length parallel to the fiber axis and of lateral dimensions approximately 20 x 60 a . | NA | {
"id": "C0074529",
"name": "silk",
"pos": [
57,
61
]
} | {
"id": "C0016042",
"name": "fibroin",
"pos": [
62,
69
]
} |
comparisons of specific activities of individual cholesteryl ester classes of liver subcellular fractions and lipoproteins suggest that the d < 1.019 lipoprotein cholesteryl esters are synthesized from newly synthesized cholesterol in the liver and are rapidly released into this lipoprotein . | NA | {
"id": "C0008387",
"name": "cholesteryl esters",
"pos": [
162,
180
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
220,
231
]
} |
ethyl acetate or chloroform solutions of tetraheptylammonium chloride , an oil-soluble quaternary amine , quantitatively extract polar , anionic lipids such as steroid or bile salt conjugates from aqueous solution by a process of anion exchange . | NA | {
"id": "C0008203",
"name": "chloride",
"pos": [
61,
69
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
230,
235
]
} |
ethyl acetate or chloroform solutions of tetraheptylammonium chloride , an oil-soluble quaternary amine , quantitatively extract polar , anionic lipids such as steroid or bile salt conjugates from aqueous solution by a process of anion exchange . | NA | {
"id": "C0028908",
"name": "oil",
"pos": [
75,
78
]
} | {
"id": "C0023779",
"name": "lipids",
"pos": [
145,
151
]
} |
the chief lipid fraction in the uropygial gland excretion of the domestic hen is a diester wax . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
10,
15
]
} | {
"id": "C0043076",
"name": "wax",
"pos": [
91,
94
]
} |
development of a rapid and sensitive radioassay has permitted study of the conversion of tryptophan to 5-hydroxytryptophan in mammalian tissues . | NA | {
"id": "C0041249",
"name": "tryptophan",
"pos": [
89,
99
]
} | {
"id": "C0000578",
"name": "hydroxytryptophan",
"pos": [
105,
122
]
} |
the treatment of the acute radiation syndrome is briefly discussed and concurrent injuries from trauma and burns and their possible implications are considered . | NA | {
"id": "C0043251",
"name": "injuries",
"pos": [
82,
90
]
} | {
"id": "C0006434",
"name": "burns",
"pos": [
107,
112
]
} |
none of factors p ( 1 ) and p ( 2 ) , 5-hydroxytryptamine , acetylcholine , adrenaline , noradrenaline , alpha-ami-nobutyric acid or glutamate duplicates the pharmacological behavior of this substance . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
76,
86
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
89,
102
]
} |
protein from escherichia coli ribosomes analyzed at ph 4.5 gave 29 bands , and the pattern was different from that of mammalian ribosomal protein . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
0,
7
]
} | {
"id": "C0035552",
"name": "ribosomal protein",
"pos": [
128,
145
]
} |
no distinct band was found when mammalian ribosomal protein was analyzed at ph 8.3 ( acidic proteins ) . | NA | {
"id": "C0035552",
"name": "ribosomal protein",
"pos": [
42,
59
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
92,
100
]
} |
cushing 's syndrome : use of lysine vasopressin to distinguish overproduction of corticotrophin by pituitary from other causes of adrenal cortical hyperfunction . | NA | {
"id": "C0010481",
"name": "cushing 's syndrome",
"pos": [
0,
19
]
} | {
"id": "C0001622",
"name": "adrenal cortical hyperfunction",
"pos": [
130,
160
]
} |
fractionation of rat antiserum demonstrated that the immunoglobulin responsible for most of the srs-a release from rat peritoneal tissue was a gammag-antibody or fraction thereof . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
21,
30
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
150,
158
]
} |
rabbits immunized to different heterologous renal antigens developed antibodies some of which are fixed to their own glomeruli ( autoantibodies ) . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
69,
79
]
} | {
"id": "C0004358",
"name": "autoantibodies",
"pos": [
129,
143
]
} |
these autoantibodies , reacting with the host 's kidneys , were directed to those antigenic determinants which were present in identical or cross-reactive form in both the immunizing antigen and the kidneys of the host . | NA | {
"id": "C0003316",
"name": "antigenic determinants",
"pos": [
82,
104
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
183,
190
]
} |
specificity of the antibodies produced by single cells following immunization with antigens bearing two types of antigenic determinants . | NA | {
"id": "C0003320",
"name": "antigens",
"pos": [
83,
91
]
} | {
"id": "C0003316",
"name": "antigenic determinants",
"pos": [
113,
135
]
} |
the individual lymph node cells from rabbits or guinea pigs immunized with hapten-protein conjugates produced antibodies against the hapten or antibodies against the antigenic determinants of the carrier molecule , never antibodies against both specificities . | NA | {
"id": "C0018593",
"name": "hapten",
"pos": [
75,
81
]
} | {
"id": "C0003316",
"name": "antigenic determinants",
"pos": [
166,
188
]
} |
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