text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
zinc-deficient rabbits fed a diet containing 25 parts of zinc per million incorporated naturally in soybean protein still retained 58 percent of an oral dose of zinc-65 16 days after the dose was given , while rabbits fed the same diet supplemented with zinc ( 54 parts per million ) as zinc oxide retained only 14 perce... | NA | {
"id": "C0043481",
"name": "zinc",
"pos": [
0,
4
]
} | {
"id": "C0043491",
"name": "zinc oxide",
"pos": [
287,
297
]
} |
two factors probably contributed to the successful infusions : the composition of the plastic catheters ( nylon ) and the location of the tip in a large central vessel . | NA | {
"id": "C0032167",
"name": "plastic",
"pos": [
86,
93
]
} | {
"id": "C0028736",
"name": "nylon",
"pos": [
106,
111
]
} |
the effect of ligand binding on the optical rotatory dispersion of myoglobin , hemoglobin , and isolated hemoglobin subunits . | NA | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
79,
89
]
} | {
"id": "C2350441",
"name": "hemoglobin subunits",
"pos": [
105,
124
]
} |
distribution of radioactivity in body fat and organs of rats treated with labeled quinestrol , ethynylestradiol or 17 beta-estradiol . | NA | {
"id": "C0034410",
"name": "quinestrol",
"pos": [
82,
92
]
} | {
"id": "C0015011",
"name": "ethynylestradiol",
"pos": [
95,
111
]
} |
penicillin-induced changes in function of the isolated perfused rat liver : alterations in thyroxine metabolism and sulfobromophthalein excretion . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
101,
111
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
136,
145
]
} |
the catalase-like activity of busycotypus hemocyanin can be simulated by amino acid chelates of copper , including arginine , histidine , and glycine . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
73,
83
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
142,
149
]
} |
however , hpl , unlike hgh , did not produce significant changes in blood glucose , plasma insulin , or plasma free fatty acid concentrations in fasting subjects before glucose administration or in carbohydrate tolerance or plasma insulin responses to glucose during 5-hour infusions . | NA | {
"id": "C0005802",
"name": "in blood glucose",
"pos": [
65,
81
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
252,
259
]
} |
these observations appear to conflict with the randle hypothesis ( the glucose-fatty acid cycle ) and raise some doubt as to whether plasma ffa concentrations are direct determinants of glucose or iri concentrations in normal man . | NA | {
"id": "C0015684",
"name": "fatty acid",
"pos": [
79,
89
]
} | {
"id": "C0015688",
"name": "ffa",
"pos": [
140,
143
]
} |
proline- ( 14 ) c was administered to five adult rhesus monkeys , and the degradation of collagen was followed by the excretion of hydroxyproline- ( 14 ) c . | NA | {
"id": "C0033382",
"name": "proline",
"pos": [
0,
7
]
} | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
131,
145
]
} |
this group included 55 children with anterior uveitis , 59 with posterior uveitis , and three with diffuse uveitis . | NA | {
"id": "C0042165",
"name": "anterior uveitis",
"pos": [
37,
53
]
} | {
"id": "C0030343",
"name": "diffuse uveitis",
"pos": [
99,
114
]
} |
this group included 55 children with anterior uveitis , 59 with posterior uveitis , and three with diffuse uveitis . | NA | {
"id": "C0042167",
"name": "posterior",
"pos": [
64,
73
]
} | {
"id": "C0030343",
"name": "diffuse uveitis",
"pos": [
99,
114
]
} |
certain proteins , i.e . albumin and fetuin , with isoelectric points of five and below were found to be potent stimulators of vesicle formation . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
8,
16
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
25,
32
]
} |
a number of acid mucopolysaccharides , including heparin , hyaluronic acid , and chondroitin sulfate , were excellent inducers . | NA | {
"id": "C0017973",
"name": "mucopolysaccharides",
"pos": [
17,
36
]
} | {
"id": "C0019134",
"name": "heparin",
"pos": [
49,
56
]
} |
two antigenic types of naturally occurring proteins related to the papain produced f ( c ) fragment of gammag-globulin have been studied . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
43,
51
]
} | {
"id": "C0017649",
"name": "globulin",
"pos": [
110,
118
]
} |
the effects of tolazamide ( 300 mg. daily ) , a new oral hypoglycemic sulfonylurea , and tolbutamide on the blood glucose , serum insulin , cholesterol and triglyceride levels were compared in 14 subjects with maturity-onset diabetes of varying severity . | NA | {
"id": "C0040372",
"name": "tolazamide",
"pos": [
15,
25
]
} | {
"id": "C0038766",
"name": "sulfonylurea",
"pos": [
70,
82
]
} |
patient variation in pernicious anaemia , as shown in a clinical trial of cyanocobalamin , hydroxocobalamin and cyanocobalamin -- zinc tannate . | NA | {
"id": "C0020316",
"name": "hydroxocobalamin",
"pos": [
91,
107
]
} | {
"id": "C0042845",
"name": "cyanocobalamin",
"pos": [
112,
126
]
} |
differential consumption of coagulation factors resulting from activation of the extrinsic ( tissue thromboplastin ) or the intrinsic ( foreign surface contact ) pathways . | NA | {
"id": "C0005789",
"name": "coagulation factors",
"pos": [
28,
47
]
} | {
"id": "C0040048",
"name": "tissue thromboplastin",
"pos": [
93,
114
]
} |
uracil , uridine , and cytidine are more effective growth factors than cytosine and thymine and , in high concentrations , render the mutant self-fertile by inducing the ascospores to resume development and maturation . | NA | {
"id": "C0041917",
"name": "uracil",
"pos": [
0,
6
]
} | {
"id": "C0040087",
"name": "thymine",
"pos": [
84,
91
]
} |
in the actinomycin-treated bacteria protein and beta-galactosidase syntheses were inhibited by 90 % , whereas flagellin synthesis was unaffected . | NA | {
"id": "C0004627",
"name": "bacteria protein",
"pos": [
27,
43
]
} | {
"id": "C0016194",
"name": "flagellin",
"pos": [
110,
119
]
} |
the other ( beta-gl ( + ) sal ( - ) ) has lost the capacity to ferment salicin , but has retained the capacity to ferment arbutin and other aryl beta-glucosides . | NA | {
"id": "C0003729",
"name": "arbutin",
"pos": [
122,
129
]
} | {
"id": "C0017765",
"name": "glucosides",
"pos": [
150,
160
]
} |
quantitative amino acid analyses indicate that glutamic acid , lysine , glucosamine , muramic acid , and serine may be present in the cell walls in equimolar amounts and that alanine is present in three to four times these quantities . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
13,
23
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
175,
182
]
} |
the effect of adding hemin to anaerobically grown cells of a strain of staphylococcus epidermidis , which was heme-deficient due to anaerobic growth , has been examined . | NA | {
"id": "C0018988",
"name": "hemin",
"pos": [
21,
26
]
} | {
"id": "C0018966",
"name": "heme",
"pos": [
110,
114
]
} |
under the latter conditions , heme pigments were formed which exhibited difference spectra similar to , but not identical with , the spectra of pigments found in anaerobic cells grown in the presence of hemin . | NA | {
"id": "C0018966",
"name": "heme",
"pos": [
30,
34
]
} | {
"id": "C0018988",
"name": "hemin",
"pos": [
203,
208
]
} |
after specified intervals of mg ( ++ ) starvation , extracts of the bacteria , or ribonucleic acid ( rna ) purified from them , was centrifuged through gradients of sucrose to separate transfer rna from ribosomal components . | NA | {
"id": "C0035668",
"name": "ribonucleic acid",
"pos": [
82,
98
]
} | {
"id": "C0035711",
"name": "transfer rna",
"pos": [
185,
197
]
} |
losses of total protein , together with the known rate of ribosome decay during mg ( ++ ) starvation , suggested that these ribosomal proteins are ultimately degraded to acid-soluble products and account for all protein lost by the starving cells . | NA | {
"id": "C0035552",
"name": "ribosomal proteins",
"pos": [
124,
142
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
212,
219
]
} |
a60549 are capable , in a complex medium containing fatty acids , of synthesizing saturated but not unsaturated fatty acids entirely or in part from acetate . | NA | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
52,
63
]
} | {
"id": "C0015690",
"name": "unsaturated fatty",
"pos": [
100,
117
]
} |
purified k88 selectively precipitated the k88 antibodies from d520 antiserum and was shown to be immunogenic in rabbits . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
46,
56
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
67,
76
]
} |
the bioelectrical characteristics of a crab nerve fiber subjected to solutions containing the impermeant anions ferrocyanide , glutamate , or ethanolsulfate substituted for chloride include prolonged slow depolarizations that elicit prolonged trains of impulses sulperimposed on the plateau portion . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
105,
111
]
} | {
"id": "C0008203",
"name": "chloride",
"pos": [
173,
181
]
} |
the isoenzyme repertory of various tissues and a hybrid enzyme produced from muscle and brain enzyme are consistent with the postulated dimeric structure of creatine phosphokinase . | NA | {
"id": "C0022173",
"name": "isoenzyme",
"pos": [
4,
13
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
94,
100
]
} |
rates of synthesis of total ribonucleic acid ( rna ) were established in two ways : ( i ) by measurements of the incorporation of exogeneous uracil and glucose carbon into rna , and ( ii ) by the accumulation of transfer rna ( trna ) , since this component is stable during mg ( ++ ) starvation . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
47,
50
]
} | {
"id": "C0035711",
"name": "transfer rna",
"pos": [
212,
224
]
} |
despite concurrent increases in arterial blood pressure , the plasma renin activity of normal subjects increased both in response to the infusion of catecholamines ( norepinephrine : epinephrine , 10:1 ) and in response to stimulation of the sympathetic nervous system by cold . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
166,
180
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
183,
194
]
} |
measurable toxic effects were not produced until the dose reached 10 g./kg . body weight , which is 10 times the ld ( 50 ) of iron similarly given as ferrous sulfate . | NA | {
"id": "C0302583",
"name": "iron",
"pos": [
126,
130
]
} | {
"id": "C0060282",
"name": "ferrous sulfate",
"pos": [
150,
165
]
} |
acute effects of human growth hormone on insulin secretion and glucose utilization in normal and growth hormone deficient subjects . | NA | {
"id": "C0169964",
"name": "human growth hormone",
"pos": [
17,
37
]
} | {
"id": "C0037663",
"name": "growth hormone",
"pos": [
97,
111
]
} |
thin-layer and gas chromatographic analysis of parathion and methyl parathion in the presence of chlorinated hydrocarbons . | NA | {
"id": "C0030514",
"name": "parathion",
"pos": [
47,
56
]
} | {
"id": "C0025709",
"name": "methyl parathion",
"pos": [
61,
77
]
} |
distribution of some synaptic transmitter suspects in cat spinal cord : glutamic acid , aspartic acid , gamma-aminobutyric acid , glycine and glutamine . | NA | {
"id": "C0061472",
"name": "glutamic",
"pos": [
72,
80
]
} | {
"id": "C0017797",
"name": "glutamine",
"pos": [
142,
151
]
} |
pyuria in infancy , and the role of suprapubic aspiration of urine in diagnosis of infection of urinary tract . | NA | {
"id": "C0034359",
"name": "pyuria",
"pos": [
0,
6
]
} | {
"id": "C0042029",
"name": "of infection",
"pos": [
80,
92
]
} |
auditory thresholds for sinusoidal tones were determined in eight patients with adrenal cortical insufficiency ( four with addison 's disease and four with panhypopituitarism ) and compared to those in normal volunteers . | NA | {
"id": "C0001623",
"name": "adrenal cortical insufficiency",
"pos": [
80,
110
]
} | {
"id": "C0001403",
"name": "addison 's disease",
"pos": [
123,
141
]
} |
human dextran-antidextran-specific precipitates from individuals immunized with dextrans containing either one or two antigenic determinants , were analyzed for their content of various amino acids . | NA | {
"id": "C0086140",
"name": "dextran",
"pos": [
6,
13
]
} | {
"id": "C0011806",
"name": "dextrans",
"pos": [
80,
88
]
} |
when serums of 11 patients with hypogammaglobulinemia were examined by acrylamide-gel electrophoresis , combined with diffusion analysis , for the gamma chain of immunoglobulin g , the electrophoretic distribution of immunoglobulin g differed from that of normal individuals . | NA | {
"id": "C0021033",
"name": "gamma",
"pos": [
36,
41
]
} | {
"id": "C0020852",
"name": "immunoglobulin g",
"pos": [
217,
233
]
} |
the reaction of ferrimyoglobin with hydroperoxides and a comparison of peroxide-induced compounds of ferrimyoglobin and cytochrome c peroxidase . | NA | {
"id": "C0020281",
"name": "hydroperoxides",
"pos": [
36,
50
]
} | {
"id": "C0031180",
"name": "peroxide",
"pos": [
71,
79
]
} |
it was also produced after intravenous injection of solutions of hemoglobin- ( 14 ) c and of reconstituted methemoglobin containing hemin- ( 14 ) c , but not after injections of methemoglobin containing globin- ( 14 ) c . | NA | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
65,
75
]
} | {
"id": "C0025635",
"name": "methemoglobin",
"pos": [
178,
191
]
} |
there was a large difference between the maximal rates of catabolism of hemoglobin to co observed after injection of damaged erythrocytes and hemoglobin solutions . | NA | {
"id": "C0019016",
"name": "a",
"pos": [
7,
8
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
142,
152
]
} |
from cells grown in three broth media of different nutrient status , i.e. , a cold extracted soil medium ( cse ) , an unamended autoclaved soil extract ( hse ) , and nutrient broth ( nb ) , antisera were produced with both quantitative and qualitative differences in antibody content . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
190,
198
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
267,
275
]
} |
portions of the globulin from the same antiserum were reacted with amounts of fitc that ranged from 12.5 to 50 mug of fitc per mg of protein . | NA | {
"id": "C0017649",
"name": "globulin",
"pos": [
16,
24
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
133,
140
]
} |
the globulin conjugates ( postlabeled globulins ) , the whole serum conjugates , and the globulins from the whole serum conjugates ( prelabeled globulins ) were compared with respect to their fluorescein-protein ( f : p ) ratios and fluorescent-antibody ( fa ) activities . | NA | {
"id": "C0017649",
"name": "globulins",
"pos": [
38,
47
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
204,
211
]
} |
the whole serum sample treated with 50 mug of fitc per mg of protein was least reactive in fa tests , and its globulin had the lowest f : p . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
61,
68
]
} | {
"id": "C0017649",
"name": "globulin",
"pos": [
110,
118
]
} |
two observations suggest that passive antibody neutralizes the immunogenic stimulus at the level of individual antigenic determinants and not merely by aggregating or precipitating entire antigenic molecules . | NA | {
"id": "C0003316",
"name": "antigenic determinants",
"pos": [
111,
133
]
} | {
"id": "C0003320",
"name": "antigenic",
"pos": [
188,
197
]
} |
the chemistry of the higher oxides of nitrogen as related to the manufacture , storage and administration of nitrous oxide . | NA | {
"id": "C0028167",
"name": "of",
"pos": [
14,
16
]
} | {
"id": "C0028215",
"name": "nitrous oxide",
"pos": [
109,
122
]
} |
two cases of poisoning by contamination of nitrous oxide with higher oxides of nitrogen during anaesthesia . | NA | {
"id": "C0028215",
"name": "nitrous oxide",
"pos": [
43,
56
]
} | {
"id": "C0028167",
"name": "oxides of",
"pos": [
69,
78
]
} |
germinability and heat resistance were restored by exogenous cations , suggesting that the thioglycolate treatment ( 30 c , 5 min ) resulted in the loss of spore ions essential for normal germination in glucose and for heat resistance . | NA | {
"id": "C0007447",
"name": "cations",
"pos": [
61,
68
]
} | {
"id": "C0022023",
"name": "ions",
"pos": [
162,
166
]
} |
glutamic acid and alanine comprise at least 60 % of the amino acid pool of b. licheniformis a-5 , b. subtilis 23 , and b. cereus t during all stages of growth and sporulation . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
18,
25
]
} | {
"id": "C0002520",
"name": "amino acid",
"pos": [
56,
66
]
} |
enzymatic oxidation of tetramethyl-p-phenylenediamine and p-phenylenediamine by the electron transport particulate fraction of azotobacter vinelandii . | NA | {
"id": "C0031468",
"name": "phenylenediamine",
"pos": [
37,
53
]
} | {
"id": "C0048678",
"name": "p-phenylenediamine",
"pos": [
58,
76
]
} |
the ability of the electron transport particulate fraction of azotobacter vinelandii strain o to oxidize tetramethyl-p-phenylenediamine ( tmpd ) and p-phenylenediamine ( ppd ) was examined in detail . | NA | {
"id": "C0031468",
"name": "phenylenediamine",
"pos": [
119,
135
]
} | {
"id": "C0048678",
"name": "p-phenylenediamine",
"pos": [
149,
167
]
} |
the highest specific activity for tmpd and ppd oxidation concentrated in the a. vinelandii o r ( 3 ) fraction . | NA | {
"id": "C0031468",
"name": "tmpd",
"pos": [
34,
38
]
} | {
"id": "C0048678",
"name": "ppd",
"pos": [
43,
46
]
} |
the probable involvement of a particle-bound cytochrome oxidase is indicated by the marked sensitivity of both tmpd and ppd oxidation to cyanide , axide , phenylhydrazine , hydroxylamine , and , to a lesser degree , carbon monoxide . | NA | {
"id": "C0031468",
"name": "tmpd",
"pos": [
111,
115
]
} | {
"id": "C0048678",
"name": "ppd",
"pos": [
120,
123
]
} |
these fatty acids were distributed as 98 % in the phospholipids and 1.9 % in the neutral lipids , of which 0.5 % were free fatty acids . | NA | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
6,
17
]
} | {
"id": "C0015688",
"name": "free fatty acids",
"pos": [
118,
134
]
} |
at a concentration of 0.5 mumole or greater of valine per mg of bacterial protein , net protein synthesis declined approximately 70 % . | NA | {
"id": "C0004627",
"name": "bacterial protein",
"pos": [
64,
81
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
88,
95
]
} |
both temperate and virulent phages were studied , including phages with ribonucleic acid , double- and single-stranded deoxyribonucleic acid ( dna ) and glucosylated dna . | NA | {
"id": "C0012935",
"name": "single-stranded deoxyribonucleic acid",
"pos": [
103,
140
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
166,
169
]
} |
the ribonucleic acid ( rna ) of these particles was shown to differ from mature ribosomal rna in both sedimentation characteristics and in elution from columns of methylated albumin-keiselguhr . | NA | {
"id": "C0035668",
"name": "ribonucleic acid",
"pos": [
4,
20
]
} | {
"id": "C0035701",
"name": "ribosomal rna",
"pos": [
80,
93
]
} |
the properties of these mutants show that there are two uptake systems for purines , one which mediates the uptake of hypoxanthine , guanine , and adenine , and the other , xanthine and uric acid . | NA | {
"id": "C0034140",
"name": "purines",
"pos": [
75,
82
]
} | {
"id": "C0001407",
"name": "adenine",
"pos": [
147,
154
]
} |
absorption of the antiserum with homologous cell suspensions removed the agglutinating , but not the neutralizing , antibody . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
18,
27
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
116,
124
]
} |
it is concluded that b. ruminicola possesses a general system for the uptake of peptides , that peptides are rapidly hydrolyzed during or after uptake , and that oligopeptides function only to supply amino acids in a form available to the organism . | NA | {
"id": "C0030956",
"name": "peptides",
"pos": [
80,
88
]
} | {
"id": "C0028954",
"name": "oligopeptides",
"pos": [
162,
175
]
} |
a pink , adenine-requiring yeast utilized adenine , hypoxanthine , or s-adenosylmethionine ( sam ) , in quantities up to 3 mumoles per 100 ml of medium , as equivalent sources of purine for cell growth , but not methylthioadenosine or s-adenosylhomocysteine . | NA | {
"id": "C0001407",
"name": "adenine",
"pos": [
9,
16
]
} | {
"id": "C0034140",
"name": "purine",
"pos": [
179,
185
]
} |
however , 6 mumoles of l-methionine had no effect on growth when adenine or hypoxanthine was the source of purine . | NA | {
"id": "C0001407",
"name": "adenine",
"pos": [
65,
72
]
} | {
"id": "C0034140",
"name": "purine",
"pos": [
107,
113
]
} |
inhibitor and spectrophotometric studies indicated that phosphorylation with hydrogen as electron donor occurs exclusively at a site in an abbreviated electron transport chain between h ( 2 ) and cytochrome b . | NA | {
"id": "C0020275",
"name": "hydrogen",
"pos": [
77,
85
]
} | {
"id": "C0011744",
"name": "h ( 2",
"pos": [
184,
189
]
} |
immunologic reaction of identity was obtained between the soluble nucleoprotein antigen and synthesized dna-histone complex , suggesting that the protein moiety of soluble nucleoprotein might in part be composed of histone . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
72,
79
]
} | {
"id": "C0028612",
"name": "nucleoprotein",
"pos": [
172,
185
]
} |
isotonic solutions of other sugars or sugar alcohols that do not readily enter human erythrocytes could be substituted for sucrose . | NA | {
"id": "C0242209",
"name": "sugars",
"pos": [
28,
34
]
} | {
"id": "C0038636",
"name": "sucrose",
"pos": [
123,
130
]
} |
formation of an infectious nucleoprotein from protein and nucleic acid isolated from a small spherical virus . | NA | {
"id": "C0028612",
"name": "nucleoprotein",
"pos": [
27,
40
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
46,
53
]
} |
when human erythrocytes were incubated in vitro with ( 14 ) c-labeled free fatty acids bound to serum albumin , labeled fatty acids were incorporated into erythrocyte triglycerides and phospholipids . | NA | {
"id": "C0015688",
"name": "free fatty",
"pos": [
70,
80
]
} | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
120,
131
]
} |
changes in plasma thyroxine concentration and metabolism , catecholamine excretion and basal oxygen consumption in man during acute exposure to high altitude . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
46,
56
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
73,
82
]
} |
in combined active-passive immunization , adsorbed tetanus toxoid produced a significantly higher response than the fluid toxoid . | NA | {
"id": "C0305062",
"name": "adsorbed tetanus toxoid",
"pos": [
42,
65
]
} | {
"id": "C0040555",
"name": "toxoid",
"pos": [
122,
128
]
} |
the connective-tissue response to immobility : a study of the chondroitin-4 and 6-sulfate and dermatan sulfate changes in periarticular connective tissue of control and immobilized knees of dogs . | NA | {
"id": "C0008454",
"name": "chondroitin",
"pos": [
62,
73
]
} | {
"id": "C0011602",
"name": "dermatan sulfate",
"pos": [
94,
110
]
} |
detailed studies of the high density lipoproteins from three patients with abetalipoproteinemia have revealed the following principal abnormalities : 1 ) high density lipoprotein 3 ( hdl3 ) is reduced in both absolute and relative concentration , although hdl2 is present in normal amounts . | NA | {
"id": "C0023821",
"name": "high density lipoproteins",
"pos": [
24,
49
]
} | {
"id": "C0023814",
"name": "high density lipoprotein 3",
"pos": [
154,
180
]
} |
sulfinpyrazone and phenylbutazone block the aggregating action of collagen , antigen-antibody complexes , and gamma globulin-coated surfaces on blood platelets . | NA | {
"id": "C0038742",
"name": "sulfinpyrazone",
"pos": [
0,
14
]
} | {
"id": "C0031463",
"name": "phenylbutazone",
"pos": [
19,
33
]
} |
in the system studied , antigenic competition between two haptenic determinants was found to be of the same extent whether the haptens were on the same or on separate carrier molecules . | NA | {
"id": "C0003316",
"name": "antigenic",
"pos": [
24,
33
]
} | {
"id": "C0018593",
"name": "haptens",
"pos": [
127,
134
]
} |
content and some characteristics of 5'-nucleotidases , pyrophosphatases and phosphomonoesterases of albino guinea pig and rat epidermis . | NA | {
"id": "C0028625",
"name": "nucleotidases",
"pos": [
39,
52
]
} | {
"id": "C0031678",
"name": "phosphomonoesterases",
"pos": [
76,
96
]
} |
the main constituent of these tubes is a protein that is related chemically and immunologically to the protein of the virus . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
41,
48
]
} | {
"id": "C0042736",
"name": "protein",
"pos": [
103,
110
]
} |
the pattern of isotope incorporation in vivo suggests that these fragments are derived from collagen that has been synthesized and rapidly degraded , or that they are rapidly synthesized but not incorporated into tropocollagen molecules . | NA | {
"id": "C0009325",
"name": "collagen",
"pos": [
92,
100
]
} | {
"id": "C0041193",
"name": "tropocollagen",
"pos": [
213,
226
]
} |
the electron spin resonance spectrum of the anion radical of i , generated electrolytically in solution , shows hyperfine structure that is due to two nitrogen atoms and four equivalent hydrogen atoms . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
44,
49
]
} | {
"id": "C0021966",
"name": "i",
"pos": [
178,
179
]
} |
active endogenous catabolism was the major factor in overall bence jones metabolism since excretion as proteinuria accounted for less than 25 % of the total metabolism . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
73,
83
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
90,
99
]
} |
the immunoglobulin class of the reactive antibodies was identified by using fluorescein-conjugated antisera specific for human igg , iga , or igm in the ifa procedure . | NA | {
"id": "C0021017",
"name": "immunoglobulin class",
"pos": [
4,
24
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
41,
51
]
} |
the immunoglobulin class of the reactive antibodies was identified by using fluorescein-conjugated antisera specific for human igg , iga , or igm in the ifa procedure . | NA | {
"id": "C0021017",
"name": "immunoglobulin class",
"pos": [
4,
24
]
} | {
"id": "C0020861",
"name": "igm",
"pos": [
142,
145
]
} |
the immunoglobulin class of the reactive antibodies was identified by using fluorescein-conjugated antisera specific for human igg , iga , or igm in the ifa procedure . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
41,
51
]
} | {
"id": "C0020960",
"name": "antisera",
"pos": [
99,
107
]
} |
clinical studies were carried out with carbamide ( urea in anhydrous , lyophilized , sterile powder form ) in 32 patients with a variety of bronchial conditions , including chronic bronchitis , cystic fibrosis , asthma , bronchiectasis and emphysema . | NA | {
"id": "C0006261",
"name": "bronchial",
"pos": [
140,
149
]
} | {
"id": "C0004096",
"name": "asthma",
"pos": [
212,
218
]
} |
clinical studies were carried out with carbamide ( urea in anhydrous , lyophilized , sterile powder form ) in 32 patients with a variety of bronchial conditions , including chronic bronchitis , cystic fibrosis , asthma , bronchiectasis and emphysema . | NA | {
"id": "C0006261",
"name": "bronchial",
"pos": [
140,
149
]
} | {
"id": "C0006267",
"name": "bronchiectasis",
"pos": [
221,
235
]
} |
biological studies suggest that these lipopolysaccharides are analogous to the endotoxins extracted from enteric organisms , as judged by their mouse lethality and their ability to provoke the local shwartzman reaction in rabbits . | NA | {
"id": "C0023810",
"name": "lipopolysaccharides",
"pos": [
38,
57
]
} | {
"id": "C0014264",
"name": "endotoxins",
"pos": [
79,
89
]
} |
1966.-auxotrophic mutants of bacillus subtilis 168 that require either tryptophan , uracil , or thymine died rapidly when deprived of any of these compounds . | NA | {
"id": "C0041917",
"name": "uracil",
"pos": [
84,
90
]
} | {
"id": "C0040087",
"name": "thymine",
"pos": [
96,
103
]
} |
in contrast , when the nucleic acids from six serologically related mycoplasmas which were isolated from tissue cultures were studied , the dna from these species could not be distinguished . | NA | {
"id": "C0028606",
"name": "nucleic",
"pos": [
23,
30
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
140,
143
]
} |
1966.-6-mercaptopurine ( mp ) utilization as a source of purine in mp-sensitive and -resistant cultures of escherichia coli was investigated . | NA | {
"id": "C0034140",
"name": "purine",
"pos": [
16,
22
]
} | {
"id": "C0000618",
"name": "sensitive",
"pos": [
70,
79
]
} |
the mode of resistance to mp in e. coli is related to an enhancement of the enzymatic degradation of mprp to the pivotal purine intermediate , imp . | NA | {
"id": "C0000618",
"name": "degradation",
"pos": [
86,
97
]
} | {
"id": "C0034140",
"name": "purine",
"pos": [
121,
127
]
} |
1966.-leptospira pomona strain 3341 was grown in association with primary fetal bovine kidney ( pbk ) and human embryonic skin-muscle fibroblastic ( he ) cells in eagle 's minimal essential medium ( mem ) with 5 % sheep serum . | NA | {
"id": "C0016030",
"name": "fibroblastic",
"pos": [
134,
146
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
154,
159
]
} |
he cells showed the same cytopathic effect as pbk fibroblastic cells , indicating that this effect was not limited to pbk fibroblastic cells . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
16,
19
]
} | {
"id": "C0016030",
"name": "fibroblastic cells",
"pos": [
122,
140
]
} |
warthin-starry stains of pbk and he cell monolayers showed masses of leptospires adhering to fibroblastic cells , whereas only a few were seen on epithelial-like cells . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
36,
40
]
} | {
"id": "C0016030",
"name": "fibroblastic cells",
"pos": [
93,
111
]
} |
fasciculation was produced in the trapezius and sternomastoid muscles of anaesthetized cats by adrenaline , noradrenaline and 5-hydroxytryptamine ( 5-ht ) put into the cisterna magna . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
95,
105
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
108,
121
]
} |
synthesis of sucrose appears to be requisite to initial accumulation from glucose or fructose , as free hexoses do not increase at the apparent saturating concentration for uptake . | NA | {
"id": "C0017725",
"name": "glucose",
"pos": [
74,
81
]
} | {
"id": "C0019494",
"name": "hexoses",
"pos": [
104,
111
]
} |
synthesis of sucrose appears to be requisite to initial accumulation from glucose or fructose , as free hexoses do not increase at the apparent saturating concentration for uptake . | NA | {
"id": "C0016745",
"name": "fructose",
"pos": [
85,
93
]
} | {
"id": "C0019494",
"name": "hexoses",
"pos": [
104,
111
]
} |
the ratio of sucrose/reducing sugars in the accumulated sugars immediately after a period of uptake was inversely related to the level of inner space invertase . | NA | {
"id": "C0038636",
"name": "sucrose",
"pos": [
13,
20
]
} | {
"id": "C0242209",
"name": "sugars",
"pos": [
56,
62
]
} |
from a series of studies on the kinetics of uptake of glucose and fructose , including competition studies , the effects of inhibitors , radioactive assay of accumulated sugars and the distribution of label in accumulated sucrose it appeared that rate limitation for glucose or fructose uptake resides in the sequence of... | NA | {
"id": "C0242209",
"name": "sugars",
"pos": [
170,
176
]
} | {
"id": "C0038636",
"name": "sucrose",
"pos": [
342,
349
]
} |
hydroxyproline subsequently isolated from the seedlings by column and thin-layer chromatography was labeled with excess o ( 18 ) , but proline was not . | NA | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
0,
14
]
} | {
"id": "C0033382",
"name": "proline",
"pos": [
135,
142
]
} |
control experiments in which seedlings were grown in h ( 2 ) o ( 18 ) and unlabeled atmospheres demonstrated that neither proline nor hydroxyproline was labeled with excess o ( 18 ) . | NA | {
"id": "C0033382",
"name": "proline",
"pos": [
122,
129
]
} | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
134,
148
]
} |
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