text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
nh ( 4 ) cl also promoted elongation , but not as effectively as did the alkali cations.cacl ( 2 ) , cocl ( 2 ) , and mgcl ( 2 ) did not enhance growth when tested at the same concentrations as the monovalent cations . | NA | {
"id": "C0007447",
"name": "cations",
"pos": [
80,
87
]
} | {
"id": "C0007449",
"name": "monovalent",
"pos": [
198,
208
]
} |
these results indicate that cells which are insufficiently prefrozen may contain freezable water which nucleates during rapid cooling in liquid nitrogen and then grows during the subsequent slow rewarming into ice masses which destroy the viability of the cells . | NA | {
"id": "C0043047",
"name": "water",
"pos": [
91,
96
]
} | {
"id": "C0020746",
"name": "ice",
"pos": [
210,
213
]
} |
fractionation of thymidine-labeled nucleic acids on a mak column showed that thymidine was exclusively incorporated into the dna fraction . | NA | {
"id": "C0028606",
"name": "nucleic acids",
"pos": [
35,
48
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
125,
128
]
} |
it is suggested that at least a part of the soybean d-rna represents a class of messenger rna . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
54,
57
]
} | {
"id": "C0035696",
"name": "messenger rna",
"pos": [
80,
93
]
} |
the behavior of exogenously supplied alanine , proline , glutamine , glutamic acid and aspartic acid in isotope competition experiments using cells of paul 's scarlet rose grown in the presence of glucose-u- ( 14 ) c was examined at higher concentrations than were used in part i of this series . | NA | {
"id": "C0017797",
"name": "glutamine",
"pos": [
57,
66
]
} | {
"id": "C0061472",
"name": "glutamic acid",
"pos": [
69,
82
]
} |
the possible role of cationic shielding in ionic stabilization of the membrane was also considered . | NA | {
"id": "C0007447",
"name": "cationic",
"pos": [
21,
29
]
} | {
"id": "C0022023",
"name": "ionic",
"pos": [
43,
48
]
} |
serine , aspartic acid , glutamic acid , and glutamine disappeared more rapidly and glycine disappeared less rapidly under anaerobic than under aerobic conditions . | NA | {
"id": "C0061472",
"name": "glutamic acid",
"pos": [
25,
38
]
} | {
"id": "C0017797",
"name": "glutamine",
"pos": [
45,
54
]
} |
the recording of state file numbers for mates born alive and dead in the same delivery will make it easier to match live birth and fetal death certificates for the preparation of detailed tabulations on multiple births . | NA | {
"id": "C0011065",
"name": "dead",
"pos": [
61,
65
]
} | {
"id": "C0015927",
"name": "fetal death",
"pos": [
131,
142
]
} |
at the oral test 100 g glucose was given and the blood sugar determined every 30 min for 180 min . | NA | {
"id": "C0017725",
"name": "glucose",
"pos": [
23,
30
]
} | {
"id": "C0005802",
"name": "blood sugar",
"pos": [
49,
60
]
} |
the double-antibody immunoassay of insulin : a standardized second antibody reaction that eliminates spurious results with human serum . | NA | {
"id": "C0021644",
"name": "antibody",
"pos": [
11,
19
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
67,
75
]
} |
2-thiouracil and 8-azaguanine also inhibit root formation 48 hours after culture initiation , but this effect is not reversed by uracil or guanine . | NA | {
"id": "C0039957",
"name": "thiouracil",
"pos": [
2,
12
]
} | {
"id": "C0041917",
"name": "uracil",
"pos": [
129,
135
]
} |
- the effect of 2-thiouracil can be reversed if the seedlings are transferred to a medium containing uracil or to blank water . | NA | {
"id": "C0039957",
"name": "thiouracil",
"pos": [
18,
28
]
} | {
"id": "C0041917",
"name": "uracil",
"pos": [
101,
107
]
} |
the simultaneous application of 2-thiouracil and uracil also leads to at least a partial reversal of the 2-thiouracil effect . | NA | {
"id": "C0041917",
"name": "uracil",
"pos": [
38,
44
]
} | {
"id": "C0039957",
"name": "thiouracil",
"pos": [
107,
117
]
} |
most of the radioactivity of the raw extract was found in glutamic acid and glutamine . | NA | {
"id": "C0061472",
"name": "glutamic acid",
"pos": [
58,
71
]
} | {
"id": "C0017797",
"name": "glutamine",
"pos": [
76,
85
]
} |
turnover rates of glutamic acid including glutamine and aspartic acid including asparagine were very high . | NA | {
"id": "C0061472",
"name": "glutamic acid",
"pos": [
18,
31
]
} | {
"id": "C0017797",
"name": "glutamine",
"pos": [
42,
51
]
} |
inhibition of gibberellic acid-induced dark germination was reversed by uracil but not by thymine , deoxycytidine and orotic acid . | NA | {
"id": "C0041917",
"name": "uracil",
"pos": [
72,
78
]
} | {
"id": "C0040087",
"name": "thymine",
"pos": [
90,
97
]
} |
and white the effect of 2-thiouracil is counteracted by rna precursors , inhibition due to 5-fluorouracil is not reversed significantly by any nucleic acid precursors . | NA | {
"id": "C0035682",
"name": "rna precursors",
"pos": [
56,
70
]
} | {
"id": "C0028603",
"name": "nucleic acid precursors",
"pos": [
143,
166
]
} |
however , about 90 % of the synthesized chlorophyll originates from protochlorophyllide reduction.by a two-minute illumination with 7000 lux 76-88 % of the protochlorophyllide but only 30-60 % of the protochlorophyll is transformed into chlorophyll ( ide ) .as to the question of the hydrogen donor for this transformati... | NA | {
"id": "C0033715",
"name": "protochlorophyllide",
"pos": [
68,
87
]
} | {
"id": "C0008260",
"name": "chlorophyll",
"pos": [
393,
404
]
} |
[ the control by phytochrome of the contents of ascorbic acid and dehydroascorbic acid in the mustard seedling ( sinapis alba l. ) ] . | NA | {
"id": "C0003968",
"name": "ascorbic acid",
"pos": [
48,
61
]
} | {
"id": "C0011177",
"name": "dehydroascorbic",
"pos": [
66,
81
]
} |
the content of dehydroascorbic acid is always very low compared to ascorbic acid ( 5-8 % of total ascorbate ) . | NA | {
"id": "C0011177",
"name": "dehydroascorbic acid",
"pos": [
15,
35
]
} | {
"id": "C0003968",
"name": "ascorbic acid",
"pos": [
67,
80
]
} |
with this method even those carotenoids can be separated which differ only in the position of a double bond , as for instance alpha- and beta-carotene , and lutein and zeaxanthin . | NA | {
"id": "C0007271",
"name": "carotenoids",
"pos": [
28,
39
]
} | {
"id": "C0053396",
"name": "beta-carotene",
"pos": [
137,
150
]
} |
thus the separation of all the principal carotenoids on a single chromatogram is possible , for example from a chlorella extract ( in order of decreasing rf-value ) : alpha-carotene , beta-carotene , lutein-5,6-epoxide ( traces ) , violaxathin , lutein , antheraxanthin , neoxanthin neo a , neoxanthin and zeaxanthin . | NA | {
"id": "C0007271",
"name": "carotenoids",
"pos": [
41,
52
]
} | {
"id": "C0053396",
"name": "beta-carotene",
"pos": [
184,
197
]
} |
furthermore the chromatographic behaviour of the carotenoids zeta-carotene , gamma-carotene , lycopene and rhodoxanthin , which are found only rarely , is described . | NA | {
"id": "C0007271",
"name": "carotenoids",
"pos": [
49,
60
]
} | {
"id": "C0043470",
"name": "zeta-carotene",
"pos": [
61,
74
]
} |
this latter effect must be attributed to a loss of phytochrome.we demonstrate in the present paper that the effects of succedaneous red and far-red irradiations can be attributed altogether to phytochrome if several assumptions concerning the stability of phytochrome 730 ( hartmann , 1966 ; wagner and mohr , 1966 ) are... | NA | {
"id": "C0250581",
"name": "a",
"pos": [
6,
7
]
} | {
"id": "C0031857",
"name": "phytochrome",
"pos": [
256,
267
]
} |
[ study of the relationships between hereditary transmission of the erythrocytic thrombocytic deficiency of glucose-6-phosphate dehydrogenase in sardinian subjects with favism ] . | NA | {
"id": "C2939465",
"name": "of",
"pos": [
8,
10
]
} | {
"id": "C0015702",
"name": "favism",
"pos": [
169,
175
]
} |
[ experimental liver cirrhosis . transaminase activity , collagen deposit and cell proliferation in the rat with dietetic cirrhosis ] . | NA | {
"id": "C0023893",
"name": "experimental liver cirrhosis",
"pos": [
2,
30
]
} | {
"id": "C0023890",
"name": "cirrhosis",
"pos": [
122,
131
]
} |
[ polarimetric study of metallic complexes of amino acids . i. methods . chelates of cu ( ii ) , zn ( ii ) , cd ( ii ) , ni ( ii ) , with d-valine and d-alanine ] . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
46,
57
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
153,
160
]
} |
[ use of the `` '' catheter-pacemaker for the electric stimulation of the heart in heart block with adams-stokes syndrome ] . | NA | {
"id": "C0018794",
"name": "heart bloc",
"pos": [
83,
93
]
} | {
"id": "C0001396",
"name": "adams-stokes syndrom",
"pos": [
100,
120
]
} |
[ determination of the traces of hydroxocobalamin ( vitamin b 12a ) in the presence of cyanocobalamin ( vitamin b 12 ) ] . | NA | {
"id": "C0020316",
"name": "hydroxocobalamin",
"pos": [
33,
49
]
} | {
"id": "C0042845",
"name": "vitamin b 12",
"pos": [
104,
116
]
} |
[ on vitamin a and vitamin a acid tolerance for the chicken during intense overdosing in the feed ] . | NA | {
"id": "C0042839",
"name": "vitamin a",
"pos": [
5,
14
]
} | {
"id": "C0040845",
"name": "vitamin a acid",
"pos": [
19,
33
]
} |
in cases of acute myocardial infarction the finding of a positive t.c.t . and its duration did not depend on the severity of the clinical symptoms nor on the measure of the laboratory changes but positive results were obtained more frequently in patients with acute coronary insufficiency ( intermediate coronary syndrom... | NA | {
"id": "C0002965",
"name": "intermediate coronary syndrome",
"pos": [
291,
321
]
} | {
"id": "C0002962",
"name": "angina pectoris",
"pos": [
327,
342
]
} |
microscopic examination of various tissues indicated that oxalic acid is deposited in the tissues in two forms : ( 1 ) crystalline calcium oxalate dihydrate in the kidney and ( 2 ) a non-crystalline complex of calcium oxalate and lipid in liver and other tissues . | NA | {
"id": "C0069715",
"name": "oxalic acid",
"pos": [
58,
69
]
} | {
"id": "C0006706",
"name": "calcium oxalate",
"pos": [
210,
225
]
} |
[ studies on immune proteins ( igg- , iga- , igm- globulin ) in mature and premature newborn infants during the 1st months after birth ] . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
20,
28
]
} | {
"id": "C0017649",
"name": "globulin",
"pos": [
50,
58
]
} |
[ drinking water in a tropical urban setting . sanitary considerations regarding earthenware jars used for household and private water storage ] . | NA | {
"id": "C0599638",
"name": "drinking water",
"pos": [
2,
16
]
} | {
"id": "C0043047",
"name": "water",
"pos": [
129,
134
]
} |
[ studies of the general venous pressure in patients with various eye diseases . ii . on the elevation of the general venous pressure in patients with perforative eye injuries and exogenous iridocyclitis following cataract extraction ] . | NA | {
"id": "C0015397",
"name": "eye diseases",
"pos": [
66,
78
]
} | {
"id": "C0015408",
"name": "eye injuries",
"pos": [
163,
175
]
} |
argentaffin cells were found in adenomatous polyps , villus adenomas , polyposis coli , peutz-jehgers ' polyps , juvenile polyposis , and adenocarcinomas . | NA | {
"id": "C0206677",
"name": "adenomatous polyps",
"pos": [
32,
50
]
} | {
"id": "C0032580",
"name": "polyposis coli",
"pos": [
71,
85
]
} |
the crypt unit was destroyed in neoplasia and argentaffin and paneth cells occurred either as a result of sequestration or were taking part in the neoplastic process . | NA | {
"id": "C0027651",
"name": "neoplasia",
"pos": [
32,
41
]
} | {
"id": "C0027671",
"name": "neoplastic process",
"pos": [
147,
165
]
} |
in patients with excess iron stores due to diseases other than idiopathic haemochromatosis ( e.g. , alcoholic cirrhosis , haemochromatosis associated with refractory anaemia ) the d.t.p.a . test demonstrated the presence of excess iron stores , but the results were very variable and did not correlate closely with the u... | NA | {
"id": "C0018995",
"name": "haemochromatosis",
"pos": [
74,
90
]
} | {
"id": "C0282193",
"name": "excess iron",
"pos": [
224,
235
]
} |
[ on fat embolism in surgery involving the use of artificial circulation , and its differential diagnosis from antifoam embolism ] . | NA | {
"id": "C0013928",
"name": "fat embolism",
"pos": [
5,
17
]
} | {
"id": "C0013922",
"name": "embolism",
"pos": [
120,
128
]
} |
[ observations on the classification of antiviral , antimicrobial and antiparasitic agents according to their administration form and method of action ] . | NA | {
"id": "C0003451",
"name": "antiviral",
"pos": [
40,
49
]
} | {
"id": "C1136254",
"name": "antimicrobial",
"pos": [
52,
65
]
} |
[ clinical-anatomical analysis of fatal outcomes in cerebrocranial trauma in combination with bone fractures and internal organ injury ] . | NA | {
"id": "C0043251",
"name": "trauma",
"pos": [
67,
73
]
} | {
"id": "C0016658",
"name": "bone fractures",
"pos": [
94,
108
]
} |
[ on the use of oletetrin in the treatment of pyoderma and some other skin diseases ] . | NA | {
"id": "C0034212",
"name": "pyoderma",
"pos": [
46,
54
]
} | {
"id": "C0037274",
"name": "skin",
"pos": [
70,
74
]
} |
[ on the significance of spondylolysis and spondylolisthesis in the practice of aviation medical expert testimony ] . | NA | {
"id": "C0038018",
"name": "spondylolysis",
"pos": [
25,
38
]
} | {
"id": "C0038016",
"name": "spondylolisthesis",
"pos": [
43,
60
]
} |
[ plastic restoration of the pinna with the use of a carcass of woven polyamide thread ] . | NA | {
"id": "C0032167",
"name": "plastic",
"pos": [
2,
9
]
} | {
"id": "C0028736",
"name": "polyamide",
"pos": [
70,
79
]
} |
[ study of the role of alveolar macrophages in respiratory physiopathology . contribution of recent experimental technics to the study of cytotoxic action of mineral particles ( silica and carbon ) , or infectious ( grippal virus ) ] . | NA | {
"id": "C0026162",
"name": "mineral",
"pos": [
158,
165
]
} | {
"id": "C0037098",
"name": "silica",
"pos": [
178,
184
]
} |
[ maternal anti-rh isoimmunization and fetal erythroblastosis in the clinica ostetrica e ginecologica of the university of perugia in the 15-year-period 1962-66 ] . | NA | {
"id": "C0035404",
"name": "rh isoimmunization",
"pos": [
16,
34
]
} | {
"id": "C0014761",
"name": "fetal erythroblastosis",
"pos": [
39,
61
]
} |
[ use of polypropylene plastic compounds in the sea water conduits of the thermal establishment at lignano ( udine ) ] . | NA | {
"id": "C0032582",
"name": "polypropylene",
"pos": [
9,
22
]
} | {
"id": "C0032167",
"name": "plastic compounds",
"pos": [
23,
40
]
} |
[ on an unusual form of splenomegaly in a former tubercular patient . hypertrophic and calcifying , chronic phlebitis of the spleen and splenic vein ] . | NA | {
"id": "C0038002",
"name": "splenomegaly",
"pos": [
24,
36
]
} | {
"id": "C0020564",
"name": "hypertrophic",
"pos": [
70,
82
]
} |
specificity of the antibody , as determined by three methods , is directed to gastrins i and ii , gastrin pentapeptide , and gastrin tetrapeptide , as well as to the stage-1 gastrin used for immunization . | NA | {
"id": "C0030859",
"name": "gastrin pentapeptide",
"pos": [
98,
118
]
} | {
"id": "C0017151",
"name": "gastrin",
"pos": [
174,
181
]
} |
specificity of the antibody , as determined by three methods , is directed to gastrins i and ii , gastrin pentapeptide , and gastrin tetrapeptide , as well as to the stage-1 gastrin used for immunization . | NA | {
"id": "C0039659",
"name": "gastrin tetrapeptide",
"pos": [
125,
145
]
} | {
"id": "C0017151",
"name": "gastrin",
"pos": [
174,
181
]
} |
the unsaturated plant lipids ( fats ) ordinarily consumed by the ruminant are hydrogenated ( saturated ) in the rumen . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
22,
28
]
} | {
"id": "C0015677",
"name": "fats",
"pos": [
31,
35
]
} |
however , dna-rna hybridization experiments show that the application of growth hormone does not stimulate the formation of new species of messenger rna . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
14,
17
]
} | {
"id": "C0035696",
"name": "messenger rna",
"pos": [
139,
152
]
} |
[ splenoportography and portohepatography via the umbilical vein in children with diseases of the liver and portal hypertension ] . | NA | {
"id": "C0023895",
"name": "diseases of the liver",
"pos": [
82,
103
]
} | {
"id": "C0020541",
"name": "portal hypertension",
"pos": [
108,
127
]
} |
[ on a complex heart abnormality with aortic ventricle and so-called corrected transposition of the large vessels ] . | NA | {
"id": "C0018798",
"name": "heart abnormality",
"pos": [
15,
32
]
} | {
"id": "C0040761",
"name": "transposition of the large vessels",
"pos": [
79,
113
]
} |
an immobilized film of an aqueous bicarbonate-carbonate solution was developed which was 4100 times more permeable to carbon dioxide than to oxygen . | NA | {
"id": "C0005367",
"name": "bicarbonate",
"pos": [
34,
45
]
} | {
"id": "C0007026",
"name": "carbonate",
"pos": [
46,
55
]
} |
effects of the optical isomers d ( minus ) and l ( plus ) inpea on heart rate , oxygen consumption and body temperature and on the cardiac and metabolic effects of adrenaline and noradrenaline in urethane-anesthetized rats . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
164,
174
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
179,
192
]
} |
[ radiologic study of bone manifestations of hereditary hemolytic anemias . generalities . common symptoms . minkowski-chauffard 's disease . thalassemia ] . | NA | {
"id": "C0002881",
"name": "hereditary hemolytic anemias",
"pos": [
45,
73
]
} | {
"id": "C0039730",
"name": "thalassemia",
"pos": [
142,
153
]
} |
effects of the optical isomers d ( minus ) and l ( plus ) inpea on the arterial pressure and on the pressor responses to noradrenaline , adrenaline and isoproterenol in urethan-anesthetised rats . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
121,
134
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
137,
147
]
} |
[ influence of the beta-adrenergic blocking function on the cardiocirculatory changes induced by isoproterenol , adrenaline and noradrenaline in normal subjects studied by a bloodless method ] . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
113,
123
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
128,
141
]
} |
[ studies on the essential oil from foeniculum vulgare . i. composition of fruit- and root oil ] . | NA | {
"id": "C0028910",
"name": "essential oil",
"pos": [
17,
30
]
} | {
"id": "C0028908",
"name": "oil",
"pos": [
91,
94
]
} |
[ the combined effect of small concentrations of furfurol , methyl alcohol , and hydrolysis ethyl alcohol in experiments ] . | NA | {
"id": "C0001963",
"name": "methyl alcohol",
"pos": [
60,
74
]
} | {
"id": "C0001962",
"name": "ethyl alcohol",
"pos": [
92,
105
]
} |
[ effects of fasting on glycemia and plasma levels of nonesterified ( ffa ) fatty acids in sheep ] . | NA | {
"id": "C0015688",
"name": "ffa",
"pos": [
70,
73
]
} | {
"id": "C0015684",
"name": "fatty",
"pos": [
76,
81
]
} |
[ change in the qualitative properties of blood serum proteins in patients with silicosis and silicotuberculosis ] . | NA | {
"id": "C0037116",
"name": "silicosis",
"pos": [
80,
89
]
} | {
"id": "C0037118",
"name": "silicotuberculosis",
"pos": [
94,
112
]
} |
[ estriol as a function of the feto-placentar unity . i. biosynthesis , excretion and metabolism of estriol in normal course of pregnancy ] . | NA | {
"id": "C0221102",
"name": "excretion",
"pos": [
72,
81
]
} | {
"id": "C0025519",
"name": "metabolism",
"pos": [
86,
96
]
} |
[ a study of botulin toxins and anatoxins by the gel filtration method . 3. separation of native botulin toxins types b and c by filtration through sephadex g-200 gel ] . | NA | {
"id": "C0006050",
"name": "a",
"pos": [
2,
3
]
} | {
"id": "C0006055",
"name": "botulin",
"pos": [
97,
104
]
} |
[ on the diagnosis of food allergy in children with eczema and several other itching dermatoses ] . | NA | {
"id": "C0033774",
"name": "itching",
"pos": [
77,
84
]
} | {
"id": "C0037274",
"name": "dermatoses",
"pos": [
85,
95
]
} |
[ research on the protein composition of the ocular tissues with new methods of electrophoretic investigation . glycoproteins and mucoproteins of ox retina ] . | NA | {
"id": "C0017968",
"name": "glycoproteins",
"pos": [
112,
125
]
} | {
"id": "C0026714",
"name": "mucoproteins",
"pos": [
130,
142
]
} |
[ prophylactic treatment of abortions during the first trimester with systematic hormonal determinations and hormonal treatment with gonadotrophins , estrogens and progesterone carried out from the beginnings of pregnancies in patients with previous pathological histories ] . | NA | {
"id": "C0032979",
"name": "first trimester",
"pos": [
49,
64
]
} | {
"id": "C0032961",
"name": "pregnancies",
"pos": [
212,
223
]
} |
[ estriol as a function of the feto-placentar unity . i. biosynthesis , excretion and metabolism of estriol in normal course of pregnancy ] . | NA | {
"id": "C0221102",
"name": "excretion",
"pos": [
72,
81
]
} | {
"id": "C0025519",
"name": "metabolism",
"pos": [
86,
96
]
} |
[ a study of the activity of allergens from house dust in the diagnosis of bronchial asthma ] . | NA | {
"id": "C0002092",
"name": "allergens",
"pos": [
29,
38
]
} | {
"id": "C0524581",
"name": "house dust",
"pos": [
44,
54
]
} |
[ research on the characteristics of pathogenic aspergillus . the major species , a. fumigatus , a. clavatus , a. flavus ] . | NA | {
"id": "C0004034",
"name": "aspergillus",
"pos": [
48,
59
]
} | {
"id": "C0004037",
"name": "fumigatus",
"pos": [
85,
94
]
} |
[ blood protein , protein fractions , and sialic acids content in patients with thyrotoxicosis treated with radioactive iodine ] . | NA | {
"id": "C0005832",
"name": "blood protein",
"pos": [
2,
15
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
18,
25
]
} |
results of studies using these methods indicate that the proportion of mitotic b cells is the same in phytohemagglutinin- and pokeweed mitogen-stimulated lymphocyte cultures , that the proportions of different cell lineages vary greatly after short-term culture of bone marrow cells , that only b cells have a clonal chr... | NA | {
"id": "C0024299",
"name": "lymphoma",
"pos": [
386,
394
]
} | {
"id": "C0019829",
"name": "hodgkin 's disease",
"pos": [
679,
697
]
} |
the present findings indicate that genetic predisposition contributes to the development of cmm in a subset of cmm patients and may be due to an enhanced susceptibility to uv light . | NA | {
"id": "C0314657",
"name": "genetic predisposition",
"pos": [
35,
57
]
} | {
"id": "C0012655",
"name": "susceptibility",
"pos": [
154,
168
]
} |
of 47 patients who began the study , 37 were successfully stabilized with standard morphine sulfate tablets and then switched to controlled-release morphine ( crm ) . | NA | {
"id": "C0066814",
"name": "morphine sulfate",
"pos": [
83,
99
]
} | {
"id": "C0026549",
"name": "morphine",
"pos": [
148,
156
]
} |
a series of nucleoside analogues ( 9-beta-d-arabinofuranosyladenine , n6-methyladenosine , 6-methylmercaptopurine ribonucleoside , tubercidin , ribavirin , and n-1-ribosyl-5-aminoimidazole-4-carboxamide riboside ) also stimulated adenine nucleotide catabolism and increased amp and imp to various extents . | NA | {
"id": "C0035546",
"name": "ribonucleoside",
"pos": [
114,
128
]
} | {
"id": "C0035525",
"name": "ribavirin",
"pos": [
144,
153
]
} |
the thiotepa metabolite triethylene phosphoramide , which hydrolyzes significantly faster than thiotepa , was significantly less cytotoxic toward the mcf-7 cells than was thiotepa itself , suggesting that it is unlikely to be the s-9 metabolite responsible for the observed increase in drug cytotoxicity . | NA | {
"id": "C0039533",
"name": "triethylene",
"pos": [
24,
35
]
} | {
"id": "C0039871",
"name": "thiotepa",
"pos": [
171,
179
]
} |
moreover , triethylene phosphoramide cytotoxicity was only partially o2 dependent and was largely unaffected by incubation in the presence of the s-9 preparation , indicating a mechanism of action distinct from that of thiotepa . | NA | {
"id": "C0039533",
"name": "triethylene phosphoramide",
"pos": [
11,
36
]
} | {
"id": "C0039871",
"name": "thiotepa",
"pos": [
219,
227
]
} |
upon treatment with the phorbol ester , 12-o-tetradecanoylphorbol-13-acetate ( tpa ) , the normally flattened c10 cells round up , while the normally bipolar , rounded pcc4 cells flatten out . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
24,
37
]
} | {
"id": "C0039654",
"name": "12-o-tetradecanoylphorbol-13-acetate",
"pos": [
40,
76
]
} |
from 1983 to 1986 , a population-based case-control study of alcohol and breast cancer ( 250 cases and 499 controls ) was conducted in a grape-farming area of northern italy , where wine consumption is widespread . | NA | {
"id": "C0001962",
"name": "alcohol",
"pos": [
61,
68
]
} | {
"id": "C0043188",
"name": "wine",
"pos": [
182,
186
]
} |
a 2-fold increase in risk was observed for consumptions of more than 40 g/day of alcohol from wine , the most common alcoholic beverage in this population . | NA | {
"id": "C0001962",
"name": "alcohol",
"pos": [
81,
88
]
} | {
"id": "C0043188",
"name": "wine",
"pos": [
94,
98
]
} |
however , the moderate risk observed seems to be limited to the relatively small group of women consuming daily amounts of alcohol in excess of 40 g , the equivalent of about half a bottle of wine or more . | NA | {
"id": "C0001962",
"name": "alcohol",
"pos": [
123,
130
]
} | {
"id": "C0043188",
"name": "wine",
"pos": [
192,
196
]
} |
elevation of the placental glutathione s-transferase form ( gst-pi ) in tumor tissues and the levels in sera of patients with cancer . | NA | {
"id": "C0017837",
"name": "glutathione s-transferase",
"pos": [
27,
52
]
} | {
"id": "C0537086",
"name": "gst-pi",
"pos": [
60,
66
]
} |
the content of glutathione s-transferase placental form ( gst-pi ) in colon and esophageal cancer tissues was determined by single radial immunodiffusion or activity inhibition tests . | NA | {
"id": "C0017837",
"name": "glutathione s-transferase",
"pos": [
15,
40
]
} | {
"id": "C0537086",
"name": "gst-pi",
"pos": [
58,
64
]
} |
because betel quid chewing has been linked to the development of oral cancer , pathobiological effects of an aqueous areca nut extract , four areca nut alkaloids ( arecoline , guvacoline , guvacine , and arecaidine ) , and four nitrosated derivatives [ n-nitrosoguvacoline , n-nitrosoguvacine , 3- ( n-nitrosomethylamino... | NA | {
"id": "C0002062",
"name": "alkaloids",
"pos": [
152,
161
]
} | {
"id": "C0003753",
"name": "arecoline",
"pos": [
164,
173
]
} |
the anthracyclines daunorubicin and doxorubicin are cancer chemotherapy agents that complex dna and are widely utilized clinically . | NA | {
"id": "C0011015",
"name": "daunorubicin",
"pos": [
19,
31
]
} | {
"id": "C0013089",
"name": "doxorubicin",
"pos": [
36,
47
]
} |
inhibition of initiator-promoter-induced skin tumorigenesis in female sencar mice fed a vitamin a-deficient diet and reappearance of tumors in mice fed a diet adequate in retinoid or beta-carotene . | NA | {
"id": "C0042839",
"name": "vitamin a",
"pos": [
88,
97
]
} | {
"id": "C0035339",
"name": "retinoid",
"pos": [
171,
179
]
} |
the distribution of several native extracellular matrix proteins ( type i , iii , and iv collagens and fibronectin ) using immunofluorescent localization is described for in two different malignant gliomas ( bt4a and bt4an ) . | NA | {
"id": "C0079323",
"name": "extracellular matrix proteins",
"pos": [
35,
64
]
} | {
"id": "C0016055",
"name": "fibronectin",
"pos": [
103,
114
]
} |
induction of cells with a chondrocyte-like phenotype by treatment with 1 alpha,25-dihydroxyvitamin d3 in a human salivary acinar cell line . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
13,
18
]
} | {
"id": "C0225369",
"name": "chondrocyte",
"pos": [
26,
37
]
} |
major alterations , such as expression of type ii collagen , alpha and beta chains of s-100 protein , and sulfated proteoglycans , were observed in these cells with a phenotype similar to chondrocytes . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
154,
159
]
} | {
"id": "C0225369",
"name": "chondrocytes",
"pos": [
188,
200
]
} |
the radioimmunological determinations of immunoreactive 'angiotensin ii ' do not truly reflect angiotensin- ( 1-8 ) octapeptide levels , and thus can not provide an accurate reflection of the efficacy of angiotensin-converting enzyme ( ace ) inhibition . | NA | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
57,
71
]
} | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
204,
215
]
} |
at peak blockade of ace , the level of plasma angiotensin ii is still related to circulating active renin and angiotensin i . | NA | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
46,
57
]
} | {
"id": "C0003006",
"name": "angiotensin i",
"pos": [
110,
123
]
} |
leucrose [ d-glucosyl-alpha ( 1 -- -- 5 ) -d-fructopyranose ] prepared by microbial-enzymatic transglycosidation from sucrose , is the first alpha ( 1 -- -- 5 ) -linked disaccharide which possesses excellent nutritional properties with regard to metabolic utilization and is well tolerated . | NA | {
"id": "C0038636",
"name": "sucrose",
"pos": [
118,
125
]
} | {
"id": "C0012611",
"name": "disaccharide",
"pos": [
169,
181
]
} |
epitestosterone in vitro displaces androgens from their bond with receptors in cytosol from rat prostates and markedly inhibits the testosterone transformation to the more effective androgen dihydrotestosterone . | NA | {
"id": "C0014594",
"name": "epitestosterone",
"pos": [
0,
15
]
} | {
"id": "C0039601",
"name": "testosterone",
"pos": [
198,
210
]
} |
unlike the viral transforming protein p160gag/v-abl , which has cytoplasmic and plasma membrane localization , a large fraction of the c-abl ( iv ) protein is nuclear , with the remainder in the cytoplasm and plasma membrane . | NA | {
"id": "C0042736",
"name": "viral",
"pos": [
11,
16
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
148,
155
]
} |
lps , lipid a , and tnf increased il6 release modestly ( 5 to 20-fold ) , while recombinant il1s ( ril1s ) stimulated this process 100 to 400-fold . | NA | {
"id": "C0023810",
"name": "lps",
"pos": [
0,
3
]
} | {
"id": "C0023767",
"name": "lipid a",
"pos": [
6,
13
]
} |
these results demonstrate similarities between endothelial cells and keratinocytes and dermal fibroblasts and differences between endothelial cells and dermal papilla cells , follicular root sheath fibroblasts and neutrophils in their response to this agent . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
59,
64
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
198,
209
]
} |
following our study in balb/c 3t3 cells and other cultured fibroblasts of the changes in myosin light chain phosphorylation associated with alterations in cell shape , attachment , and receptor patching , we have now determined the corresponding changes in cytoskeletal myosin distribution , and in the cellular calcium ... | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
59,
70
]
} | {
"id": "C0007634",
"name": "cellular",
"pos": [
303,
311
]
} |
the myelin-associated glycoprotein ( mag ) is a 100-kd , integral membrane glycoprotein that is a member of the immunoglobulin superfamily and appears to function in interactions between myelin-forming cells ( both oligodendrocytes and schwann cells ) and the axolemma . | NA | {
"id": "C0129439",
"name": "myelin-associated glycoprotein",
"pos": [
4,
34
]
} | {
"id": "C0025248",
"name": "membrane",
"pos": [
66,
74
]
} |
parenteral injection of peptidoglycan-polysaccharide ( pg-ps ) polymers from certain bacterial species produces spontaneously relapsing erosive synovitis in susceptible rat strains , and normally subarthropathic amounts of pg-ps and lipopolysaccharide ( endotoxin ) can reactivate arthritis initially induced by pg-ps . | NA | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
233,
251
]
} | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
254,
263
]
} |
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