text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
polyclonal iga is increased in rheumatoid arthritis , sjogren 's syndrome , ankylosing spondylitis , reiter 's syndrome , and reactive arthritis following yersinia infection . | NA | {
"id": "C0003873",
"name": "rheumatoid arthritis",
"pos": [
31,
51
]
} | {
"id": "C1527336",
"name": "sjogren 's syndrome",
"pos": [
54,
73
]
} |
serum concentrations of iga correlate with activity of rheumatoid arthritis and ankylosing spondylitis , and serum iga immune complexes are associated with rheumatoid vasculitis , suggesting that iga contributes to the pathogenesis of arthritis . | NA | {
"id": "C0003873",
"name": "rheumatoid arthritis",
"pos": [
55,
75
]
} | {
"id": "C0240903",
"name": "rheumatoid vasculitis",
"pos": [
156,
177
]
} |
in addition to the simple muscular strains and contusions of the back the physician must be aware of the possibility of underlying spondylolysis , spondylolisthesis , scheuerman 's kyphosis , and variants of scheuerman 's . | NA | {
"id": "C0038018",
"name": "spondylolysis",
"pos": [
131,
144
]
} | {
"id": "C0038016",
"name": "spondylolisthesis",
"pos": [
147,
164
]
} |
the effect of regucalcin , a calcium-binding protein isolated from rat liver cytosol , on ca2+-adenosine triphosphatase ( atpase ) activity in hepatic microsomes was investigated . | NA | {
"id": "C0001476",
"name": "ca2",
"pos": [
90,
93
]
} | {
"id": "C0001473",
"name": "atpase",
"pos": [
122,
128
]
} |
the steady state levels of messenger ribonucleic acids ( mrnas ) for sperm-type and non-sperm-type proteins were determined by blot hybridization using the rna of the mouse cell line 38-2 containing the inducible rat c-myc gene cultured under various conditions . | NA | {
"id": "C0035696",
"name": "messenger ribonucleic acids",
"pos": [
27,
54
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
156,
159
]
} |
although all 8 mcab reacted with both hcp and human proinsulin ( hpi ) , they could specifically recognize human insulin from hpi and were highly species specific without cross-reaction with proinsulin , insulin and c-peptide of other species tested . | NA | {
"id": "C0795635",
"name": "human insulin",
"pos": [
107,
120
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
204,
211
]
} |
although all 8 mcab reacted with both hcp and human proinsulin ( hpi ) , they could specifically recognize human insulin from hpi and were highly species specific without cross-reaction with proinsulin , insulin and c-peptide of other species tested . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
52,
62
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
204,
211
]
} |
although all 8 mcab reacted with both hcp and human proinsulin ( hpi ) , they could specifically recognize human insulin from hpi and were highly species specific without cross-reaction with proinsulin , insulin and c-peptide of other species tested . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
52,
62
]
} | {
"id": "C0006558",
"name": "c-peptide",
"pos": [
216,
225
]
} |
the results showed that the antigenic determinants of the mcabs are not located in the site of hgh comprising residues 1-43 but on the three non-overlapping antigenic sites of hgh . | NA | {
"id": "C0003316",
"name": "antigenic",
"pos": [
28,
37
]
} | {
"id": "C0003320",
"name": "antigenic",
"pos": [
157,
166
]
} |
the results showed that the antigenic determinants of the mcabs are not located in the site of hgh comprising residues 1-43 but on the three non-overlapping antigenic sites of hgh . | NA | {
"id": "C0037663",
"name": "hgh",
"pos": [
95,
98
]
} | {
"id": "C0169964",
"name": "hgh",
"pos": [
176,
179
]
} |
while another 83 cases with yin deficiency yang excess syndrome ( ydyes ) of the same three diseases were employed as control group . | NA | {
"id": "C0039082",
"name": "syndrome",
"pos": [
55,
63
]
} | {
"id": "C0012634",
"name": "diseases",
"pos": [
92,
100
]
} |
the collision-induced remote site fragmentation process of closed-shell ions , such as carboxylate anions , is a very potent analytical tool for the structural determination of fatty acids . | NA | {
"id": "C0022023",
"name": "ions",
"pos": [
72,
76
]
} | {
"id": "C0003075",
"name": "anions",
"pos": [
99,
105
]
} |
according to the results , all three glycosaminoglycans used ( chondroitin-4-sulfate , chondroitin-6-sulfate and heparin ) were effective but to a different extent . | NA | {
"id": "C0017973",
"name": "glycosaminoglycans",
"pos": [
37,
55
]
} | {
"id": "C0019134",
"name": "heparin",
"pos": [
113,
120
]
} |
11 patients presented neurologic symptoms : 5 had focal processes associated in 2 cases with deep coma , 4 had cryptococcal meningitidis , 1 demonstrated peripheral facial paralysis , and there was one case of abnormal movement , choreo-athetotic type . | NA | {
"id": "C0013384",
"name": "abnormal",
"pos": [
210,
218
]
} | {
"id": "C0004158",
"name": "athetotic",
"pos": [
237,
246
]
} |
the clinical aspects observed were often evocative : lupus vulgaris , 28.8 % , scrofuloderma , 28.8 % , specific adenitis , 13.3 % , tuberculosis verrucosa cutis , 13.3 % , gum , 13.9 % , ulcerous ctb , 2.2 % . | NA | {
"id": "C0024131",
"name": "lupus vulgaris",
"pos": [
53,
67
]
} | {
"id": "C0041309",
"name": "ctb",
"pos": [
197,
200
]
} |
an investigation of sequential changes in urine composition , levels of dna synthesis and morphology of bladder epithelium following administration of the tumor promoters sodium ascorbate ( asa-na ) or butylated hydroxyanisole ( bha ) and the non-promoter ascorbic acid ( asa ) for 36 weeks was performed . | NA | {
"id": "C0887557",
"name": "sodium ascorbate",
"pos": [
171,
187
]
} | {
"id": "C0003968",
"name": "asa",
"pos": [
272,
275
]
} |
we have recently reported that the tobacco-related nitrosamines n-nitrosodiethylamine ( den ) and 4- ( methyl-nitrosamino ) -1- ( 3-pyridyl ) -1-butanone ( nnk ) stimulate cell proliferation in cell lines derived from human neuroendocrine carcinoma and adenocarcinoma ( comprised of clara cells ) of the lung . | NA | {
"id": "C0028197",
"name": "nitrosamines",
"pos": [
51,
63
]
} | {
"id": "C0012200",
"name": "nitrosodiethylamine",
"pos": [
66,
85
]
} |
we have recently reported that the tobacco-related nitrosamines n-nitrosodiethylamine ( den ) and 4- ( methyl-nitrosamino ) -1- ( 3-pyridyl ) -1-butanone ( nnk ) stimulate cell proliferation in cell lines derived from human neuroendocrine carcinoma and adenocarcinoma ( comprised of clara cells ) of the lung . | NA | {
"id": "C0206695",
"name": "neuroendocrine carcinoma",
"pos": [
224,
248
]
} | {
"id": "C0001418",
"name": "adenocarcinoma",
"pos": [
253,
267
]
} |
in contrast to isolated hepatocytes from normal livers those from macronodular cirrhosis had a lowered cellular content of triglycerides , phospholipids and cholesterol but not of cholesterol esters and free fatty acids . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
157,
168
]
} | {
"id": "C0008387",
"name": "cholesterol esters",
"pos": [
180,
198
]
} |
the production of eicosanoids by cardiac fibroblasts may be substantial during the healing of myocardial infarction due to their dramatic proliferation and the increased prostaglandin production per cell . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
41,
52
]
} | {
"id": "C0007634",
"name": "the",
"pos": [
156,
159
]
} |
thus , complement-derived anaphylatoxins may participate in immediate hypersensitivity reactions in which the heart is a target organ . | NA | {
"id": "C0009498",
"name": "complement",
"pos": [
7,
17
]
} | {
"id": "C0002791",
"name": "anaphylatoxins",
"pos": [
26,
40
]
} |
complement-derived anaphylatoxins appear to promote the same mediator release that has been initiated by the antigen-antibody reaction ; | NA | {
"id": "C0009498",
"name": "complement",
"pos": [
0,
10
]
} | {
"id": "C0002791",
"name": "anaphylatoxins",
"pos": [
19,
33
]
} |
time-dependent risk of and predictors for cardiac arrest recurrence in survivors of out-of-hospital cardiac arrest with chronic coronary artery disease . | NA | {
"id": "C0018790",
"name": "cardiac arrest",
"pos": [
42,
56
]
} | {
"id": "C2936490",
"name": "of out",
"pos": [
81,
87
]
} |
favorable changes in lipoproteins , inhibition of platelet aggregation , reduction of serum thromboxane ( tx ) , altered plasma-membrane fluidity , and reduced production of growth factors ( mitogens ) have all been implicated as possibly being involved in the inhibition of arteriosclerosis by fish oil ( fo ) , which i... | NA | {
"id": "C0016157",
"name": "fish oil",
"pos": [
295,
303
]
} | {
"id": "C0015689",
"name": "omega 3 fatty acids",
"pos": [
330,
349
]
} |
these observations underscore the need for further studies to clarify the interactions between fo ( omega 3 fatty acids ) and paracrine cellular mitogenic factors in the context of atherosclerosis prevention . | NA | {
"id": "C0016157",
"name": "fo",
"pos": [
39,
41
]
} | {
"id": "C0015689",
"name": "omega 3 fatty acids",
"pos": [
100,
119
]
} |
we report a new method to determine the association constants ( k ' f ) of calcium for organic anions , from the perturbation by the added anion of the equilibrium solubilization of calcium [ 14c ] oxalate monohydrate crystals ( caox* ) . | NA | {
"id": "C0016327",
"name": "f",
"pos": [
68,
69
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
139,
144
]
} |
this decreased free [ ca2+ ] , causing more caox* to dissolve in amounts related to the concentration of added anion and its k ' f for ca2+ . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
111,
116
]
} | {
"id": "C0016327",
"name": "f",
"pos": [
131,
132
]
} |
the sensitivity of the caox method permits determination of k ' f values with small quantities and low concentrations of the anions and calcium . | NA | {
"id": "C0016327",
"name": "f",
"pos": [
17,
18
]
} | {
"id": "C0003075",
"name": "anions",
"pos": [
125,
131
]
} |
the soluble brain protein 14-3-2 first described by moore and mcgregor in 1965 is now known to be a cell specific isoenzyme of the glycolytic enzyme enolase ( ec 4.2.1.11 ) , designated neuron specific enolase ( nse ) . | NA | {
"id": "C0022173",
"name": "isoenzyme",
"pos": [
114,
123
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
142,
148
]
} |
three other boys , who were probably affected by the disease , had severe asphyxia and died shortly after birth . | NA | {
"id": "C0004044",
"name": "asphyxia",
"pos": [
74,
82
]
} | {
"id": "C0011065",
"name": "died",
"pos": [
87,
91
]
} |
we present the first case of holt-oram syndrome associated with the lethal congenital heart defect of hypoplastic left heart syndrome . | NA | {
"id": "C0018798",
"name": "the",
"pos": [
11,
14
]
} | {
"id": "C0152101",
"name": "heart",
"pos": [
119,
124
]
} |
in the fibroblasts , catalase and glutathione peroxidase activities did not differ significantly from control cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
7,
18
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
110,
115
]
} |
initial hiv serologic profiles , obtained when all patients were asymptomatic , were highly predictive for progression of the hiv infection : the initial pattern of low anti-p24 antibody and positive p24 antigenaemia conferred the worst prognosis , with all patients in this group developing arc or aids within 36 months... | NA | {
"id": "C0019693",
"name": "hiv infection",
"pos": [
126,
139
]
} | {
"id": "C0001175",
"name": "aids",
"pos": [
299,
303
]
} |
it was inferred that polyclonal rabbit tg antiserum includes antibodies to all the epitopes seen by chicken tg-aab and many more besides . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
42,
51
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
61,
71
]
} |
it was inferred that polyclonal rabbit tg antiserum includes antibodies to all the epitopes seen by chicken tg-aab and many more besides . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
61,
71
]
} | {
"id": "C0004358",
"name": "aab",
"pos": [
111,
114
]
} |
these results suggest a role for complement , in particular the membrane attack complex in the pathogenesis of autoimmune thyroid disease . | NA | {
"id": "C0009498",
"name": "complement",
"pos": [
33,
43
]
} | {
"id": "C0009545",
"name": "membrane attack complex",
"pos": [
64,
87
]
} |
resting serum conjugated catecholamines -- epinephrine ( e ) , norepinephrine ( ne ) , dopamine ( d ) , free e and free d -- were significantly elevated above the normal mean ( p less than 0.01 ) . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
43,
54
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
63,
77
]
} |
studies of kinetic isotope effects using deuterium and 18o2 show that p-450b catalyses this reaction with epitestosterone via the formation of a gem diol , whereas , with testosterone as substrate , one-third of the product is formed via the same mechanism while the remainder results from the mechanism described as dua... | NA | {
"id": "C0011744",
"name": "deuterium",
"pos": [
41,
50
]
} | {
"id": "C0020275",
"name": "hydrogen",
"pos": [
322,
330
]
} |
studies of kinetic isotope effects using deuterium and 18o2 show that p-450b catalyses this reaction with epitestosterone via the formation of a gem diol , whereas , with testosterone as substrate , one-third of the product is formed via the same mechanism while the remainder results from the mechanism described as dua... | NA | {
"id": "C0014594",
"name": "epitestosterone",
"pos": [
106,
121
]
} | {
"id": "C0039601",
"name": "testosterone",
"pos": [
171,
183
]
} |
three high affinity receptors ( nk1 , nk2 and nk3 ) recognizing the c-terminal end of tachykinins have been described , with probable endogenous ligands substance p ( sp- ) , neurokinin a and neurokinin b , respectively . | NA | {
"id": "C0039241",
"name": "tachykinins",
"pos": [
86,
97
]
} | {
"id": "C0038585",
"name": "substance p",
"pos": [
153,
164
]
} |
three high affinity receptors ( nk1 , nk2 and nk3 ) recognizing the c-terminal end of tachykinins have been described , with probable endogenous ligands substance p ( sp- ) , neurokinin a and neurokinin b , respectively . | NA | {
"id": "C0039241",
"name": "tachykinins",
"pos": [
86,
97
]
} | {
"id": "C0038581",
"name": "neurokinin a",
"pos": [
175,
187
]
} |
three high affinity receptors ( nk1 , nk2 and nk3 ) recognizing the c-terminal end of tachykinins have been described , with probable endogenous ligands substance p ( sp- ) , neurokinin a and neurokinin b , respectively . | NA | {
"id": "C0039241",
"name": "tachykinins",
"pos": [
86,
97
]
} | {
"id": "C0027847",
"name": "neurokinin b",
"pos": [
192,
204
]
} |
we found that normal pbmc respond with increased numbers of cd3-positive cells when exposed to pha or pwm and that the response by normal cd8-positive cells was greater than that by cd4-positive cells . | NA | {
"id": "C1321301",
"name": "pbmc",
"pos": [
21,
25
]
} | {
"id": "C0007634",
"name": "the",
"pos": [
115,
118
]
} |
when we evaluated an in vitro cell model of ada deficiency using an ada inhibitor , erythro-9- ( 2-hydroxy-3-nonyl ) adenine ( ehna ) , we found that the inhibitory effect of ehna plus deoxyadenosine on mitogen-stimulated pbmc could not be prevented by il-2 . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
30,
34
]
} | {
"id": "C1321301",
"name": "pbmc",
"pos": [
222,
226
]
} |
some patients with ventricular tachycardia can be successfully treated with these devices but this group is at risk of tachycardia acceleration or degeneration in response to pacing . | NA | {
"id": "C0042514",
"name": "ventricular tachycardia",
"pos": [
19,
42
]
} | {
"id": "C0039231",
"name": "tachycardia",
"pos": [
119,
130
]
} |
there were no clinical and laboratory findings of pseudohypoparathyroidism , pseudopseudohypoparathyroidism , or fibrodysplasia ossificans progressiva in this case . | NA | {
"id": "C0033806",
"name": "pseudohypoparathyroidism",
"pos": [
50,
74
]
} | {
"id": "C0033835",
"name": "pseudopseudohypoparathyroidism",
"pos": [
77,
107
]
} |
intestinal structure , lactase ( beta-galactosidase ; ec 3.2.1.23 ) activity and alkaline phosphatase activity have been determined in mouse jejunal and ileal tissues before and during infection with the intestinal parasite nematospiroides dubius . | NA | {
"id": "C0083183",
"name": "lactase",
"pos": [
23,
30
]
} | {
"id": "C0005220",
"name": "beta-galactosidase",
"pos": [
33,
51
]
} |
the severity of associated liver disease ( cirrhosis vs no cirrhosis ) did not influence muscle strength . | NA | {
"id": "C0023895",
"name": "the",
"pos": [
0,
3
]
} | {
"id": "C0023890",
"name": "cirrhosis",
"pos": [
59,
68
]
} |
apnea may be secondary to physiologic abnormalities that cause airway obstruction or to cardiac disease or arrhythmia , seizure disorders , infection , or other disorders . | NA | {
"id": "C0018799",
"name": "cardiac disease",
"pos": [
88,
103
]
} | {
"id": "C0003811",
"name": "arrhythmia",
"pos": [
107,
117
]
} |
in six healthy volunteers plasma concentrations of adrenaline , noradrenaline and dopamine were measured at rest and during dynamic forearm exercise at submaximal and maximal intensities . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
51,
61
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
64,
77
]
} |
arterial and venous concentrations of adrenaline and noradrenaline increased with forearm exercise at all workloads . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
38,
48
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
53,
66
]
} |
the increases in adrenaline and noradrenaline were almost linearly related to the increase in heart rate with no levelling off at maximal exercise intensities . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
17,
27
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
32,
45
]
} |
it is concluded that dynamic exercise with the forearm muscle group causes a small but significant activation of the sympatho-adrenal system as reflected by increases in plasma concentrations of adrenaline and noradrenaline . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
195,
205
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
210,
223
]
} |
albumin concentrations of 329 diabetic patients were measured using two laser turbidimetric methods for albuminuria and proteinuria , two semiquantitative tests ( albusure and albustix ) , and a routine albumin radioimmunoassay . | NA | {
"id": "C0001925",
"name": "albuminuria",
"pos": [
104,
115
]
} | {
"id": "C0033687",
"name": "proteinuria",
"pos": [
120,
131
]
} |
the four methods in the order laser immunoturbidimetric for albuminuria , laser turbidimetric for proteinuria , albusure and albustix gave the following results : sensitivity 0.97 , 0.93 , 0.97 and 0.81 ; | NA | {
"id": "C0001925",
"name": "albuminuria",
"pos": [
60,
71
]
} | {
"id": "C0033687",
"name": "proteinuria",
"pos": [
98,
109
]
} |
a retrospective survey of symptomatic awareness of hypoglycaemia was performed in 189 randomly selected patients with insulin-treated diabetes who had been transferred from highly purified animal insulins to human insulin in the preceding 24 months . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
118,
125
]
} | {
"id": "C0795635",
"name": "human insulin",
"pos": [
208,
221
]
} |
peak levels of adrenaline ( 6.44 +/- 1.62 nmol l-1 ) and noradrenaline ( 2.29 +/- 0.39 nmol l-1 ) were found 10 min later . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
15,
25
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
57,
70
]
} |
concentrations of epinephrine and norepinephrine tended ( p greater than .10 ) to be elevated in fed pigs , relative to those of fasted counterparts . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
18,
29
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
34,
48
]
} |
in addition , nuclear protein transport is compared with transport of proteins into the endoplasmic reticulum and the mitochondria . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
22,
29
]
} | {
"id": "C0007292",
"name": "transport",
"pos": [
57,
66
]
} |
they allow successful treatment of almost all mycobacterial infections and diseases ( including tuberculosis and leprosy ) and a number of infections caused by gram-negative and gram-positive microorganisms and by pneumocystis carinii . | NA | {
"id": "C0026918",
"name": "mycobacterial infections",
"pos": [
46,
70
]
} | {
"id": "C0023343",
"name": "leprosy",
"pos": [
113,
120
]
} |
in this study the intraphagocytic bioactivity of difloxacin , ciprofloxacin , pefloxacin and fleroxacin was investigated using human neutrophils and a combination of a radioassay , a colony-counting method and a fluorescence microassay which enables us to differentiate between intracellular bacteriostatic and bacterici... | NA | {
"id": "C0008809",
"name": "ciprofloxacin",
"pos": [
62,
75
]
} | {
"id": "C0085161",
"name": "fleroxacin",
"pos": [
93,
103
]
} |
it was found that difloxacin , ciprofloxacin and to a lesser extent pefloxacin and fleroxacin possess intracellular bacteriostatic activity for s. aureus and l. monocytogenes . | NA | {
"id": "C0008809",
"name": "ciprofloxacin",
"pos": [
31,
44
]
} | {
"id": "C0085161",
"name": "fleroxacin",
"pos": [
83,
93
]
} |
the results were : cholesterol 166.7 +/- 30.9 mg/ml , triglyceride 81.1 +/- 42.3 mg/dl , hdl-cholesterol ( hdlc ) 57.4 +/- 11.6 mg/dl , hdl2c 20.6 +/- 9.8 mg/dl and hdl3c 37.1 +/- 7.8 mg/dl . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
19,
30
]
} | {
"id": "C0023822",
"name": "hdl-cholesterol",
"pos": [
89,
104
]
} |
adding glucose ( glc ) , glutamic acid ( glu ) , or alpha-ketoglutaric acid ( alpha k ) had little or no effect , and the same was true for combinations of glc plus alpha k , aspartic acid ( asp ) plus proline ( pro ) and glutamine ( gln ) , and minerals plus vitamins ( mv ) . | NA | {
"id": "C0061472",
"name": "glu",
"pos": [
7,
10
]
} | {
"id": "C0017797",
"name": "glutamine",
"pos": [
222,
231
]
} |
when asp , gln , pro , and alpha k were combined with glc and/or mv and added to l-15 , there was appreciable growth stimulation , but best results were obtained when glu was also included . | NA | {
"id": "C0017797",
"name": "gln",
"pos": [
11,
14
]
} | {
"id": "C0061472",
"name": "glu",
"pos": [
167,
170
]
} |
multiple biopsies were taken from 50 patients with endoscopic appearance of duodenitis in order to study the relationship between gastric metaplasia in duodenum and the presence of campylobacter-like organisms ( clos ) and the development of duodenal ulcer disease . | NA | {
"id": "C0013298",
"name": "duodenitis",
"pos": [
76,
86
]
} | {
"id": "C0013289",
"name": "the",
"pos": [
223,
226
]
} |
in this study , we evaluated health-related quality of life of 150 patients with inflammatory bowel disease ( 63 ulcerative colitis , 87 crohn 's disease ) . | NA | {
"id": "C0021390",
"name": "inflammatory bowel disease",
"pos": [
81,
107
]
} | {
"id": "C0010346",
"name": "crohn 's disease",
"pos": [
137,
153
]
} |
mucosal hyperplasia was demonstrated by the finding that in each segment , mucosal weight , protein , and dna content per centimeter of gut length were significantly ( p less than 0.01 ) higher ( +38 to + 78 % ) in the resected group than in transected controls . | NA | {
"id": "C0037088",
"name": "finding",
"pos": [
44,
51
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
83,
89
]
} |
we studied the effects of intravenous infusion of synthetic oxyntomodulin ( proglucagon 33-69 ) , a potential hormone from the ileal mucosa , on fasting and postprandial gastric acid secretion , gastric emptying , gastroduodenal motility , and pancreatic secretion of trypsin and lipase measured simultaneously in six no... | NA | {
"id": "C0086379",
"name": "oxyntomodulin",
"pos": [
60,
73
]
} | {
"id": "C0072092",
"name": "proglucagon",
"pos": [
76,
87
]
} |
mature tigh cdna was inserted in an escherichia coli expression vector which led to the production of tigh protein with a yield estimated to be 20 % of the total bacterial proteins . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
107,
114
]
} | {
"id": "C0004627",
"name": "bacterial proteins",
"pos": [
162,
180
]
} |
when atherosclerosis was induced by dietary cholesterol , the cholesterol and peroxide lipids were increased in the intima of aortae ( p less than 0.05 ) . | NA | {
"id": "C0008395",
"name": "dietary cholesterol",
"pos": [
36,
55
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
62,
73
]
} |
phase separation of myelin proteins in triton x-114 : differential behavior of myelin basic protein in purified myelin and in cultured oligodendrocytes . | NA | {
"id": "C0026972",
"name": "myelin proteins",
"pos": [
20,
35
]
} | {
"id": "C0014063",
"name": "myelin basic protein",
"pos": [
79,
99
]
} |
the study was aimed at investigating the changes in the blood serum concentrations of growth hormone ( hgh ) , insulin and placental lactogen ( hpl ) in the newborns of diabetic mothers as compared to those born from physiological pregnancies . | NA | {
"id": "C0037663",
"name": "growth hormone",
"pos": [
86,
100
]
} | {
"id": "C3714500",
"name": "hgh",
"pos": [
103,
106
]
} |
the gradient , which contributes to the lens optical quality , seems to be accompanied by an uneven distribution of the crystallin classes , with the nucleus usually enriched in gamma- and the cortex in alpha-crystallins . | NA | {
"id": "C0010422",
"name": "crystallin",
"pos": [
120,
130
]
} | {
"id": "C0002257",
"name": "alpha-crystallins",
"pos": [
203,
220
]
} |
after exposure to hyperoxia in organotypic cultures cocultured with fibroblast monolayers , ultrastructural abnormalities of surfactant ( large lamellar bodies with disordered lamellae and abnormal shape ) were detected in cells from 18- to 19-day gestation fetuses . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
68,
78
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
223,
228
]
} |
the antibodies 2c1 and 3f9 are distinct from and apparently more specific than previously described monoclonal antibodies raised to rat type ii cells . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
4,
14
]
} | {
"id": "C0003250",
"name": "monoclonal",
"pos": [
100,
110
]
} |
sulfinpyrazone , phenylbutazone , and auranofin completely inhibited the release of azurophilic granules ( myeloperoxidase ) and tertiary granules ( beta-d-glucuronidase ) when formyl-l-methionyl-l-leucyl-l-phenylalanine ( fmlp ) was used as the stimulant , and inhibited azurophilic granule release by 69 % , 19 % , and... | NA | {
"id": "C0038742",
"name": "sulfinpyrazone",
"pos": [
0,
14
]
} | {
"id": "C0031463",
"name": "phenylbutazone",
"pos": [
17,
31
]
} |
the bioavailability of phenytoin from acc-9653 versus intravenously administered sodium phenytoin was determined using a crossover design for intravenous and intramuscular administration of acc-9653 to healthy volunteers . | NA | {
"id": "C0031507",
"name": "phenytoin",
"pos": [
23,
32
]
} | {
"id": "C0237417",
"name": "sodium phenytoin",
"pos": [
81,
97
]
} |
absolute bioavailability of phenytoin derived from acc-9653 in each subject was calculated as the ratio of the phenytoin area under the plasma concentration time curve for time 0 to infinity [ auc ( 0-inf ) ] after acc-9653 divided by the phenytoin auc ( 0-inf ) after intravenous sodium phenytoin . | NA | {
"id": "C0031507",
"name": "phenytoin",
"pos": [
28,
37
]
} | {
"id": "C0237417",
"name": "sodium phenytoin",
"pos": [
281,
297
]
} |
the absolute bioavailability of phenytoin derived from acc-9653 in subjects with therapeutic plasma phenytoin concentrations is being studied in patients given simultaneous infusions of stable isotope-labeled tracer doses of acc-0653 and sodium phenytoin . | NA | {
"id": "C0031507",
"name": "phenytoin",
"pos": [
32,
41
]
} | {
"id": "C0237417",
"name": "sodium phenytoin",
"pos": [
238,
254
]
} |
antiepileptic drugs such as vigabatrin [ gamma vinyl gaba ( gvg ) ] , a drug rationally developed to treat resistant epilepsy , can enhance gaba transmission in these regions and may thereby afford seizure protection . | NA | {
"id": "C0048044",
"name": "gamma vinyl gaba",
"pos": [
41,
57
]
} | {
"id": "C0016904",
"name": "gaba",
"pos": [
140,
144
]
} |
antiepileptic drugs such as vigabatrin [ gamma vinyl gaba ( gvg ) ] , a drug rationally developed to treat resistant epilepsy , can enhance gaba transmission in these regions and may thereby afford seizure protection . | NA | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
117,
125
]
} | {
"id": "C0036572",
"name": "seizure",
"pos": [
198,
205
]
} |
cerebrospinal fluid ( csf ) concentrations of total gaba , free gaba , homocarnosine , homovanillic acid ( hva ) , gvg , and 5-hydroxyindolacetic acid were measured up to seven days after a single dose . | NA | {
"id": "C0016904",
"name": "gaba",
"pos": [
52,
56
]
} | {
"id": "C0048044",
"name": "gvg",
"pos": [
115,
118
]
} |
because of the potential efficacy of gvg in controlling previously therapeutic-resistant seizures and of the absence of evidence of significant toxicity in humans , carefully monitored clinical trials of gvg in therapy-resistant patients with epilepsy should continue . | NA | {
"id": "C0036572",
"name": "seizures",
"pos": [
89,
97
]
} | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
243,
251
]
} |
factors that could be important include maturation of g cell function , alterations in gastrin metabolism and excretion , and changes in gastrointestinal motility with increasing age . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
95,
105
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
110,
119
]
} |
these circular dnas enter ofage gels and are resolved over the same region of the gel as linear dnas from 260 to 2200 kb . | NA | {
"id": "C0012925",
"name": "circular dnas",
"pos": [
6,
19
]
} | {
"id": "C0012854",
"name": "dnas",
"pos": [
96,
100
]
} |
the orientation and stretching of dna molecules in the gel matrix indicates that end-on migration , or reptation , is a likely mechanism for dna electrophoresis in agarose gels . | NA | {
"id": "C0012854",
"name": "dna molecules",
"pos": [
34,
47
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
166,
167
]
} |
gel electrophoresis has provided much of the detailed information we have about the properties of dna junctions , stable branched molecules formed from oligonucleotide or polynucleotide strands . | NA | {
"id": "C0028953",
"name": "oligonucleotide",
"pos": [
152,
167
]
} | {
"id": "C0032550",
"name": "polynucleotide",
"pos": [
171,
185
]
} |
the use of gel electrophoresis in studies of nucleic acid-protein ( especially dna-protein ) interactions has yielded much qualitative and quantitative information about a variety of such systems . | NA | {
"id": "C0028606",
"name": "nucleic acid",
"pos": [
45,
57
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
79,
82
]
} |
activation of t cells by antigen , lectin or a combination of phorbol ester ( pma ) and calcium ionophore ( a23187 ) leads to the induction of a set of lymphokine genes . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
62,
75
]
} | {
"id": "C0039654",
"name": "pma",
"pos": [
78,
81
]
} |
here we show that the lpam-1 beta subunit ( beta p ) is immunochemically and biochemically distinct from previously defined integrin beta subunits , suggesting that beta p represents a novel integrin beta subunit . | NA | {
"id": "C1136316",
"name": "integrin beta subunits",
"pos": [
124,
146
]
} | {
"id": "C0021701",
"name": "integrin",
"pos": [
191,
199
]
} |
the dna-protein and protein-protein interactions proposed for the stability of nucleoprotein complexes at the origin of replication in prokaryotes are also thought to impart regulatory precision in eukaryotic dna replication . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
8,
15
]
} | {
"id": "C0028612",
"name": "nucleoprotein",
"pos": [
79,
92
]
} |
however , the molecular basis for the synergistic action of nfi and dbp during replication is at present unknown . | NA | {
"id": "C0069116",
"name": "nfi",
"pos": [
60,
63
]
} | {
"id": "C0012940",
"name": "dbp",
"pos": [
68,
71
]
} |
we report here that dbp increases the affinity of nfi for its binding site in the replication origin . | NA | {
"id": "C0012940",
"name": "dbp",
"pos": [
20,
23
]
} | {
"id": "C0069116",
"name": "nfi",
"pos": [
50,
53
]
} |
other single-stranded dna binding proteins could not substitute for dbp in increasing nfi affinity for its binding site . | NA | {
"id": "C0012940",
"name": "dbp",
"pos": [
68,
71
]
} | {
"id": "C0069116",
"name": "nfi",
"pos": [
86,
89
]
} |
in addition , dbp was found to alter the binding kinetics of nfi , both by increasing the rate of association and decreasing the rate of dissociation of nfi with the dna template . | NA | {
"id": "C0012940",
"name": "dbp",
"pos": [
14,
17
]
} | {
"id": "C0069116",
"name": "nfi",
"pos": [
153,
156
]
} |
the co-operativity between nfi and dbp was also demonstrated on another dna template , a human nfi site ( fib2 ) , suggesting that this interaction is of general occurrence and not restricted to the adenovirus origin of replication . | NA | {
"id": "C0069116",
"name": "nfi",
"pos": [
27,
30
]
} | {
"id": "C0012940",
"name": "dbp",
"pos": [
35,
38
]
} |
protein p6 of bacillus subtilis phage phi 29 binds specifically to the ends of the viral dna that contain the replication origins , giving rise to a nucleoprotein structure . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
0,
7
]
} | {
"id": "C0028612",
"name": "nucleoprotein",
"pos": [
149,
162
]
} |
one chemical , n-amyl nitrite , was negative in the mouse lymphoma assay , while the other five chemicals , n-butyl , isobutyl , iso-amyl , sec-butyl , and n-propyl nitrite , were positive . | NA | {
"id": "C0002711",
"name": "amyl nitrite",
"pos": [
17,
29
]
} | {
"id": "C0028137",
"name": "nitrite",
"pos": [
165,
172
]
} |
these data indicate that gender and training do not affect acth and cortisol concentrations before , during , and after 30 min of treadmill running at 80 % of maximum heart rate , whereas b-en concentrations are higher in males under these conditions . | NA | {
"id": "C0079399",
"name": "gender",
"pos": [
25,
31
]
} | {
"id": "C0086582",
"name": "males",
"pos": [
222,
227
]
} |
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