text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
bacteremia is a marker of mortality , and the majority of bacteremia cases are secondary to another bacterial infection site . | NA | {
"id": "C0004610",
"name": "bacteremia",
"pos": [
0,
10
]
} | {
"id": "C0004623",
"name": "bacterial infection site",
"pos": [
100,
124
]
} |
the in vitro activity of cefetamet , the microbiologically active metabolite of the orally administered prodrug cefetamet pivoxil , was compared with that of cephalexin , cefaclor , cefuroxime and amoxicillin . | NA | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
158,
168
]
} | {
"id": "C0007537",
"name": "cefaclor",
"pos": [
171,
179
]
} |
the activity of cefcanel against anaerobic cocci , clostridium perfringens , bacteroides fragilis , bacteroides spp . and fusobacteria was determined by the agar dilution method and compared with the activity of cefaclor , cephalexin , cefadroxil , phenoxymethylpenicillin and ampicillin . | NA | {
"id": "C0007537",
"name": "cefaclor",
"pos": [
212,
220
]
} | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
223,
233
]
} |
the activity of cefcanel against anaerobic cocci , clostridium perfringens , bacteroides fragilis , bacteroides spp . and fusobacteria was determined by the agar dilution method and compared with the activity of cefaclor , cephalexin , cefadroxil , phenoxymethylpenicillin and ampicillin . | NA | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
223,
233
]
} | {
"id": "C0007538",
"name": "cefadroxil",
"pos": [
236,
246
]
} |
through its weak antagonist action on d-2da receptors and a potent inhibitory effect on 5-ht2 receptors , as well as its ability to increase da and 5-ht2 release , clozapine may be able to permit more normal dopaminergic function in the anterior pituitary , the mesostriatal , mesolimbic and mesocortical regions . | NA | {
"id": "C0013030",
"name": "da",
"pos": [
41,
43
]
} | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
208,
220
]
} |
low grade lymphomas were encountered in 30 and 10 % of the patients with primary nodal and extranodal nhl , respectively . | NA | {
"id": "C0079747",
"name": "low grade lymphomas",
"pos": [
0,
19
]
} | {
"id": "C0024305",
"name": "nhl",
"pos": [
102,
105
]
} |
the ability of the vasodilator hydralazine and the alpha 1-adrenoceptor antagonist prazosin to increase sympathoadrenal outflow was compared by measuring plasma norepinephrine and epinephrine concentrations , norepinephrine clearance and norepinephrine spillover rate into plasma in conscious sprague-dawley rats and spo... | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
164,
175
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
238,
252
]
} |
neither prazosin nor hydralazine affected norepinephrine clearance , and only prazosin elicited a significant rise in plasma epinephrine concentration . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
42,
56
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
125,
136
]
} |
this was closely correlated with the evoked overflow of alpha-methylnoradrenaline ( mna , r = 0.9 ) and noradrenaline ( na , r = 0.7 ) but not dopamine ( da ) or alpha-methyldopamine ( mda ) . | NA | {
"id": "C0025805",
"name": "alpha-methylnoradrenaline",
"pos": [
56,
81
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
104,
117
]
} |
the effect of the delta-selective agonist [ d-pen2 , d-pen5 ] enkephalin ( dpdpe ) on the antinociception produced by intracerebroventricular ( i.c.v . ) administration of the mu agonists morphine , [ d-ala2 , nmephe4 , gly-ol5 ] enkephalin ( dago ) , [ nmephe3 , d-pro4 ] morphiceptin ( plo17 ) , beta-endorphin , phena... | NA | {
"id": "C0525856",
"name": "dpdpe",
"pos": [
75,
80
]
} | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
230,
240
]
} |
the effect of the delta-selective agonist [ d-pen2 , d-pen5 ] enkephalin ( dpdpe ) on the antinociception produced by intracerebroventricular ( i.c.v . ) administration of the mu agonists morphine , [ d-ala2 , nmephe4 , gly-ol5 ] enkephalin ( dago ) , [ nmephe3 , d-pro4 ] morphiceptin ( plo17 ) , beta-endorphin , phena... | NA | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
62,
72
]
} | {
"id": "C0525773",
"name": "dago",
"pos": [
243,
247
]
} |
tachykinins produced a concentration-related contraction of the isolated guinea-pig gallbladder , with a rank order of potency neurokinin a ( nka ) greater than arg-neurokinin b = neurokinin b ( nkb ) greater than substance p ( sp ) . | NA | {
"id": "C0039241",
"name": "tachykinins",
"pos": [
0,
11
]
} | {
"id": "C0027847",
"name": "neurokinin b",
"pos": [
180,
192
]
} |
tachykinins produced a concentration-related contraction of the isolated guinea-pig gallbladder , with a rank order of potency neurokinin a ( nka ) greater than arg-neurokinin b = neurokinin b ( nkb ) greater than substance p ( sp ) . | NA | {
"id": "C0039241",
"name": "tachykinins",
"pos": [
0,
11
]
} | {
"id": "C0038585",
"name": "substance p",
"pos": [
214,
225
]
} |
it was not inhibited by inhibitors of metalloproteases ( edta , 1.10 phenanthroline ) , serine proteases ( phenylmethylsulfonyl fluoride , elastatinal ) , or cysteine proteases ( iodoacetate , n-ethylmaleimide ) and it seems to be unrelated to the previously known proteases of mesenchymal and hematopoietic cells . | NA | {
"id": "C2717970",
"name": "cysteine",
"pos": [
158,
166
]
} | {
"id": "C0030940",
"name": "proteases",
"pos": [
265,
274
]
} |
the combined effects of carbohydrates and glutamine were investigated in diploid strains of normal human skin fibroblasts cultured for 21 days under eight different culture conditions : hexose-free medium or medium containing d-glucose , d-galactose , or d-fructose , with or without added glutamine . | NA | {
"id": "C0019494",
"name": "hexose",
"pos": [
186,
192
]
} | {
"id": "C0016945",
"name": "galactose",
"pos": [
240,
249
]
} |
the combined effects of carbohydrates and glutamine were investigated in diploid strains of normal human skin fibroblasts cultured for 21 days under eight different culture conditions : hexose-free medium or medium containing d-glucose , d-galactose , or d-fructose , with or without added glutamine . | NA | {
"id": "C0019494",
"name": "hexose",
"pos": [
186,
192
]
} | {
"id": "C0016745",
"name": "fructose",
"pos": [
257,
265
]
} |
phagocytosis had little effect on the secretion of acid hydrolases , while intracellular proteases increased significantly . | NA | {
"id": "C0020289",
"name": "hydrolases",
"pos": [
56,
66
]
} | {
"id": "C0030940",
"name": "proteases",
"pos": [
89,
98
]
} |
conditioned media were exhaustively dialyzed against 0.5 n acetic acid , lyophilized , and subjected to western blot analysis , using as primary antibody an igg fraction prepared from goat antiserum directed against human platelet-derived growth factor . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
145,
153
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
189,
198
]
} |
the proteins from 30 samples of normal human aqueous humor were separated into major fractions by sodium dodecyl-sulfate polyacrylamide gel electrophoresis , transferred to nitrocellulose , and probed with lectins to characterize the glycated polypeptides . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
4,
12
]
} | {
"id": "C0023206",
"name": "lectins",
"pos": [
206,
213
]
} |
nissl-counterstained sections failed to reveal magnocellular neurons which were not immunoreactive for the ngf receptor , suggesting that reductions in immunocytochemically stained neurons reflects neuron loss and not the failure of viable neurons to synthesize ngf receptors . | NA | {
"id": "C0254837",
"name": "ngf receptor",
"pos": [
107,
119
]
} | {
"id": "C0132173",
"name": "ngf receptors",
"pos": [
262,
275
]
} |
we wished to determine whether dopamine released from the transplant also reinstated dopaminergic inhibition of striatal acetylcholine release . | NA | {
"id": "C0013030",
"name": "dopamine",
"pos": [
31,
39
]
} | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
85,
97
]
} |
the gsh/gssg redox potential is shifted in favour of the reduced form in this cirrhosis model . | NA | {
"id": "C0017817",
"name": "gsh",
"pos": [
4,
7
]
} | {
"id": "C0061516",
"name": "gssg",
"pos": [
8,
12
]
} |
strain ct28 was resistant to josamycin , erythromycin , roxithromycin , lincomycin and clindamycin but sensitive to minocycline . | NA | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
41,
53
]
} | {
"id": "C0035891",
"name": "roxithromycin",
"pos": [
56,
69
]
} |
strain ct28 was resistant to josamycin , erythromycin , roxithromycin , lincomycin and clindamycin but sensitive to minocycline . | NA | {
"id": "C0023726",
"name": "lincomycin",
"pos": [
72,
82
]
} | {
"id": "C0008947",
"name": "clindamycin",
"pos": [
87,
98
]
} |
employing electrophoretically ( sds-page ) separated normal platelet membrane proteins in an immunoblot assay , serum igg and igm antibodies were found to be directed to antigenic determinants situated on glycoprotein gp iib ( 140 kda ) in all patients , but also on smaller proteins of molecular weights between 30 and ... | NA | {
"id": "C0025252",
"name": "membrane proteins",
"pos": [
69,
86
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
275,
283
]
} |
overnight fasting plasma lipoprotein and lipid concentrations were measured in a group of 76 patients with peripheral arterial disease ( pad ) -- main symptom : intermittent claudication -- and compared to those of 21 controls , matched with the patients according to age , sex , body-mass index , alcohol and tobacco co... | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
25,
36
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
41,
46
]
} |
thus , not only were the hdl-c and ldl-c levels different in the pad group , but we also found a correlation between hdl-c and the severity of vascular disease . | NA | {
"id": "C0085096",
"name": "pad",
"pos": [
65,
68
]
} | {
"id": "C0042373",
"name": "vascular disease",
"pos": [
143,
159
]
} |
the material studied included four benign leiomyomas , seven malignant leiomyomas and three malignant epithelioid leiomyomas . | NA | {
"id": "C0023267",
"name": "leiomyomas",
"pos": [
42,
52
]
} | {
"id": "C0086533",
"name": "epithelioid leiomyomas",
"pos": [
102,
124
]
} |
the number of neoplastic cells showing vimentin expression was larger in malignant , especially epithelioid leiomyomas than in non-malignant leiomyomas . | NA | {
"id": "C0086533",
"name": "epithelioid leiomyomas",
"pos": [
96,
118
]
} | {
"id": "C0023267",
"name": "leiomyomas",
"pos": [
141,
151
]
} |
on the other hand , in fetal plasma 84.4 % of immunoreactive igf-i/smc was eluted in 40k region on the 20th week , but on the 26th week , 71.6 % of igf-i/smc was eluted in 150k region and after the 35th week , more than 70 % of igf-i/smc was determined in 150k region as observed in adult plasma . | NA | {
"id": "C0037657",
"name": "igf",
"pos": [
61,
64
]
} | {
"id": "C0021665",
"name": "smc",
"pos": [
234,
237
]
} |
in contrast , dexamethasone markedly stimulated the incorporation of [ 14c ] proline and the synthesis of [ 14c ] hydroxyproline , an index of the synthesis of type iv collagen . | NA | {
"id": "C0033382",
"name": "proline",
"pos": [
77,
84
]
} | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
114,
128
]
} |
among various kinds of sweat gland tumors and other skin tumors , syringoma and eccrine porocarcinoma were intensely stained with pha . | NA | {
"id": "C0038987",
"name": "of sweat gland tumors",
"pos": [
20,
41
]
} | {
"id": "C0037286",
"name": "skin tumors",
"pos": [
52,
63
]
} |
inocula of tumorigenic cells showed an increased size after addition of fibroblasts to the inocula . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
23,
28
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
72,
83
]
} |
to the first class belong apolipoprotein ( apo ) b and some apoe-containing lipoproteins of the very-low-density ( vldl ) , intermediate-density ( idl ) and low-density ( ldl ) lipoprotein fractions . | NA | {
"id": "C0023825",
"name": "lipoproteins",
"pos": [
76,
88
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
177,
188
]
} |
a total of 1244 patients with acute upper or lower respiratory tract infection were randomized to receive , twice daily for 7 days , either capsules of enteric-coated pellets of erythromycin base at a dose of 1 g/day or erythromycin ethylsuccinate tablets at a dose of 2 g/day in a single-blind , multicentre study . | NA | {
"id": "C0014806",
"name": "erythromycin base",
"pos": [
178,
195
]
} | {
"id": "C0014810",
"name": "erythromycin",
"pos": [
220,
232
]
} |
the neuropeptide galanin inhibits glucose-stimulated insulin release in dogs and rodents and has been proposed as having a role in the control of insulin release in humans . | NA | {
"id": "C0027895",
"name": "neuropeptide",
"pos": [
4,
16
]
} | {
"id": "C0060993",
"name": "galanin",
"pos": [
17,
24
]
} |
disturbances of prostaglandin i2 ( pgi2 , prostacyclin ) production by adipose tissue contribute to the pathogenesis of diabetic ketoacidosis and may contribute to the pathogenesis of hypertension and vascular disease . | NA | {
"id": "C0020538",
"name": "hypertension",
"pos": [
184,
196
]
} | {
"id": "C0042373",
"name": "vascular disease",
"pos": [
201,
217
]
} |
moreover , the 2-d analyses demonstrate that purification of membrane protein fractions from both human and rat islets before the immunoprecipitation efficiently removes background proteins and substantially increases the specificity of 64k autoantibody measurements by traditional methods . | NA | {
"id": "C0025252",
"name": "membrane protein",
"pos": [
61,
77
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
181,
189
]
} |
although maximal isoproterenol-stimulated lipolysis was decreased in adipocytes from shr rats , the ability of insulin to inhibit catecholamine-stimulated lipolysis was at least as great in adipocytes from shr as from wky rats . | NA | {
"id": "C0022245",
"name": "isoproterenol",
"pos": [
17,
30
]
} | {
"id": "C0007412",
"name": "catecholamine",
"pos": [
130,
143
]
} |
we conclude that 1 ) pco women have significant insulin resistance that is independent of obesity , changes in body composition , and impairment of glucose tolerance , 2 ) pco and obesity have a synergistic deleterious effect on glucose tolerance , 3 ) hyperinsulinemia in pco is not the result of decreased insulin clea... | NA | {
"id": "C0021655",
"name": "insulin resistance",
"pos": [
48,
66
]
} | {
"id": "C0020459",
"name": "hyperinsulinemia",
"pos": [
253,
269
]
} |
of the 52 patients with normal coronary angiograms , 19 ( 37 % ) had gastro-oesophageal reflux disease and abnormal oesophageal motility , 5 ( 10 % ) had gastro-oesophageal reflux disease alone , and 7 ( 13 % ) had oesophageal motility disorder alone . | NA | {
"id": "C0017168",
"name": "gastro-oesophageal reflux disease",
"pos": [
69,
102
]
} | {
"id": "C0014858",
"name": "oesophageal motility disorder",
"pos": [
215,
244
]
} |
the activity and the content of phospholipase a2 ( pla2 ) , a potential 'toxin ' in pancreatitis , were determined separately by respective methods in pancreatic tissue resected from 22 patients treated for acute necrotizing pancreatitis . | NA | {
"id": "C0030305",
"name": "pancreatitis",
"pos": [
84,
96
]
} | {
"id": "C0267941",
"name": "acute necrotizing pancreatitis",
"pos": [
207,
237
]
} |
it is concluded that galanin may be an important neuropeptide for the modulation of resting les tone . | NA | {
"id": "C0060993",
"name": "galanin",
"pos": [
21,
28
]
} | {
"id": "C0027895",
"name": "neuropeptide",
"pos": [
49,
61
]
} |
effects of acute and chronic ethanol administration on the gastrointestinal hormones gastrin , enteroglucagon , pancreatic glucagon and peptide yy in the rat . | NA | {
"id": "C0017182",
"name": "gastrointestinal",
"pos": [
59,
75
]
} | {
"id": "C0017151",
"name": "gastrin",
"pos": [
85,
92
]
} |
effects of acute and chronic ethanol administration on the gastrointestinal hormones gastrin , enteroglucagon , pancreatic glucagon and peptide yy in the rat . | NA | {
"id": "C0017182",
"name": "gastrointestinal",
"pos": [
59,
75
]
} | {
"id": "C0070358",
"name": "peptide yy",
"pos": [
136,
146
]
} |
the effect of acute and chronic ethanol administration on the gastrointestinal hormones gastrin , enteroglucagon ( eg ) , pancreatic glucagon ( pg ) and peptide yy ( pyy ) was studied in the rat alcohol model . | NA | {
"id": "C0017182",
"name": "gastrointestinal",
"pos": [
62,
78
]
} | {
"id": "C0017151",
"name": "gastrin",
"pos": [
88,
95
]
} |
the effect of acute and chronic ethanol administration on the gastrointestinal hormones gastrin , enteroglucagon ( eg ) , pancreatic glucagon ( pg ) and peptide yy ( pyy ) was studied in the rat alcohol model . | NA | {
"id": "C0017182",
"name": "gastrointestinal",
"pos": [
62,
78
]
} | {
"id": "C0070358",
"name": "peptide yy",
"pos": [
153,
163
]
} |
three empirical potentials of the lennard-jones type taken from literature were used to calculate van der waals contributions to the base-pair couples stacking energies in b-dna and a-dna type double helical conformations . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
174,
177
]
} | {
"id": "C0000702",
"name": "a-dna",
"pos": [
182,
187
]
} |
( 3 ) tilt of base pairs occurred around zero in b-dna and between 15-20 degrees c in a-dna , in agreement with the experimental observations ; | NA | {
"id": "C0919262",
"name": "b-dna",
"pos": [
49,
54
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
88,
91
]
} |
this is particularly true for sulfur dioxide which is a highly water-soluble gas and is normally absorbed in the upper airway during nasal breathing . | NA | {
"id": "C0038777",
"name": "sulfur dioxide",
"pos": [
30,
44
]
} | {
"id": "C0017110",
"name": "gas",
"pos": [
77,
80
]
} |
an operational classification based on immunoreactants provides insight to possible pathogenetic mechanisms participating in the genesis of urticaria and angioedema . | NA | {
"id": "C0042109",
"name": "urticaria",
"pos": [
140,
149
]
} | {
"id": "C0002994",
"name": "angioedema",
"pos": [
154,
164
]
} |
high-level synthesis of proteins containing protease and polymerase moieties ( 110-kda protein ) and polymerase alone ( 87-kda protein ) were obtained from cells containing different plasmid constructions . | NA | {
"id": "C0034861",
"name": "synthesis",
"pos": [
11,
20
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
127,
134
]
} |
escherichia coli contains two l-asparaginase isozymes : a secreted high-affinity enzyme , l-asparaginase ii ( ansii ) , and a low-affinity cytoplasmic enzyme , l-asparaginase i ( ansi ) , which is encoded by the ansa gene . | NA | {
"id": "C0022173",
"name": "isozymes",
"pos": [
45,
53
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
151,
157
]
} |
cloned proteins are expressed fused to a 2-kda leader sequence containing a run of six aparagine residues which considerably improves the stability of the recombinant proteins , but does not interfere with immunological assays . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
7,
15
]
} | {
"id": "C0034861",
"name": "recombinant proteins",
"pos": [
155,
175
]
} |
none of the five with a dna diploid pattern had a relapse and both with the dna nondiploid pattern had relapses . | NA | {
"id": "C0000702",
"name": "a dna",
"pos": [
22,
27
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
76,
79
]
} |
a recombinant dna probe hybridizing specifically to human repeat dna sequence ( phy10 ) of which about 3000 copies are present on the y chromosome was used for sex determination of degraded dna samples of blood stains . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
0,
1
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
190,
193
]
} |
[ hiv infection caused by nursing care ? hiv infection in the mother of a son with aids ] . | NA | {
"id": "C0019693",
"name": "hiv infection",
"pos": [
2,
15
]
} | {
"id": "C0001175",
"name": "aids",
"pos": [
83,
87
]
} |
the case of a 78-year-old woman with a 2-year history of chronic persistent oral candidiasis , in whom an hiv infection ( stage iii , frankfurt classification according to brodt , stage 6 walter reed staging classification , stage iv who classification , manifest aids according to the new 1988 classification ) was diag... | NA | {
"id": "C0019693",
"name": "hiv infection",
"pos": [
106,
119
]
} | {
"id": "C0001175",
"name": "aids",
"pos": [
264,
268
]
} |
in a pilot study the therapeutic effect of 2 x 500 mg etofibrate ( lipo merz retard ) on lipids and lipoproteins , fibrinolytic activity and clinical parameters was studied for four weeks in hyperlipidemic patients suffering from arteriosclerosis obliterans ( fontaine stage ii/iii ) . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
89,
95
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
100,
112
]
} |
dopamine has been widely utilized in the treatment of acute congestive heart failure , ibopamine , the diisobutyrate ester of n-methyldopamine ( epinine ) , is a novel inotropic agent that , unlike-dopamine , is orally active . | NA | {
"id": "C0011498",
"name": "methyldopamine",
"pos": [
128,
142
]
} | {
"id": "C0013030",
"name": "dopamine",
"pos": [
198,
206
]
} |
eighty-three livers ( 27 autopsies and 56 biopsies , m : f = 63:20 ) , which were either normal or of various hepatic disorders such as acute or chronic hepatitis , cirrhosis and hepatocellular carcinomas , were examined by the method of avidin-biotin-complex technique . | NA | {
"id": "C0023895",
"name": "hepatic disorders",
"pos": [
110,
127
]
} | {
"id": "C0023890",
"name": "cirrhosis",
"pos": [
165,
174
]
} |
within a multicentre observation study on non-hodgkin lymphomas ( nhl ) diagnosed according to the kiel classification advanced stages iii and iv of centrocytic ( cc ) lymphoma exhibited the worst prognosis among lymphomas of low-grade malignancy with a 5-year survival probability of less than 10 per cent . | NA | {
"id": "C0024305",
"name": "non-hodgkin lymphomas",
"pos": [
42,
63
]
} | {
"id": "C0079747",
"name": "lymphomas",
"pos": [
213,
222
]
} |
we describe a novel mutation in the delta globin gene of a compound heterozygote for delta o thalassemia and a deletion type g gamma + ( a gamma delta beta ) zero thalassemia . | NA | {
"id": "C0271990",
"name": "delta",
"pos": [
36,
41
]
} | {
"id": "C0039730",
"name": "thalassemia",
"pos": [
163,
174
]
} |
type xiii collagen is a recently described collagen that resembles in structure the short-chain collagens of types ix , x , and xii . | NA | {
"id": "C0086030",
"name": "type xiii collagen",
"pos": [
0,
18
]
} | {
"id": "C0969670",
"name": "short-chain collagens",
"pos": [
84,
105
]
} |
type xiii collagen is a recently described collagen that resembles in structure the short-chain collagens of types ix , x , and xii . | NA | {
"id": "C0009325",
"name": "collagen",
"pos": [
10,
18
]
} | {
"id": "C0969670",
"name": "short-chain collagens",
"pos": [
84,
105
]
} |
inhibin ( inh ) is a gonadal glycoprotein hormone that regulates pituitary fsh secretion and may also play a role in the regulation of androgen biosynthesis . | NA | {
"id": "C0021463",
"name": "inhibin",
"pos": [
0,
7
]
} | {
"id": "C0017968",
"name": "glycoprotein",
"pos": [
29,
41
]
} |
the alternative hypothesis , that anti-cd4/anti-cd8 mabs can directly confer negative regulatory signals to the ctl is not supported by our studies with antibody-directed lysis mediated by a cd4+ , cd8+ ctl clone . | NA | {
"id": "C0003250",
"name": "mabs",
"pos": [
52,
56
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
153,
161
]
} |
while the physiologic ligand for the vea antigen has yet to be identified , the integrin identified by mabs h9.2b8 and 8.18e12 mediates cell adhesion to a well-defined group of ligands consisting of the ecm-proteins fibronectin , fibrinogen , and vitronectin . | NA | {
"id": "C0079323",
"name": "ecm-proteins",
"pos": [
203,
215
]
} | {
"id": "C0016055",
"name": "fibronectin",
"pos": [
216,
227
]
} |
after intra-articular injection , antigen retention is much enhanced with high molecular weight cationized proteins , like albumin or immunoglobulin , compared to small-sized proteins like myoglobulin and lysozyme . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
123,
130
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
175,
183
]
} |
incubation of 4b.14a cells with syngeneic antigen-presenting cells , previously pulsed with the 89-101 synthetic peptide or with 80 u/ml of il-2 , or allogeneic h-2ik cells , resulted in a significant increase in the accumulation of intracellular camp . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
21,
26
]
} | {
"id": "C3485979",
"name": "allogeneic",
"pos": [
150,
160
]
} |
natural anti-chondrocyte cytotoxicity of normal rat splenocytes , peritoneal cells and thymocytes was tested by means of 51cr-release assay . | NA | {
"id": "C0225369",
"name": "chondrocyte",
"pos": [
13,
24
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
77,
82
]
} |
bone marrow-derived murine macrophages were used to study the relationship between the proliferative response of macrophages to macrophage colony-stimulating factor ( csf-1 ) and their activation for cytocidal activity against tumour cells . | NA | {
"id": "C0079784",
"name": "macrophage",
"pos": [
27,
37
]
} | {
"id": "C0009392",
"name": "csf-1",
"pos": [
167,
172
]
} |
several antigens including the 23,000 mw antigen were recognized suggesting that it shared common epitopes with higher mw proteins . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
8,
15
]
} | {
"id": "C0003316",
"name": "epitopes",
"pos": [
98,
106
]
} |
during the treatment 10 patients developed a leukoderma vitiligo-like localized to the areas of topical application of the allergens and to the flare-up site ; | NA | {
"id": "C0162835",
"name": "leukoderma",
"pos": [
45,
55
]
} | {
"id": "C0042900",
"name": "vitiligo",
"pos": [
56,
64
]
} |
preincubation of both cell types with ril-6 at concentrations of 5 and 50 ng/ml primed the cells for enhanced generation of oxygen radicals following stimulation with the chemotactic peptide f-met-leu-phe or the phorbol ester pma . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
212,
225
]
} | {
"id": "C0039654",
"name": "pma",
"pos": [
226,
229
]
} |
mabs specific for unique epitopes on secretory iga or free secretory component ( fsc ) were produced and evaluated . | NA | {
"id": "C0020838",
"name": "secretory iga",
"pos": [
37,
50
]
} | {
"id": "C0036538",
"name": "secretory",
"pos": [
59,
68
]
} |
this second labelling of rfc- cells could represent immigration of precursor cells , a wave of proliferation in initially labelled precursors , and/or the formation of mature cells from the initially labelled precursors . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
30,
35
]
} | {
"id": "C0018956",
"name": "precursor cells",
"pos": [
67,
82
]
} |
increased neopterin release was achieved by gamma-ifn or its inducers ( pha , il-2 ) , by interfering with the biopterin production by increased levels of cgmp or by decreasing the activity of the t suppressor cells . | NA | {
"id": "C0068527",
"name": "neopterin",
"pos": [
10,
19
]
} | {
"id": "C0005562",
"name": "biopterin",
"pos": [
111,
120
]
} |
to study the effect of reserpine on anthracycline antibiotic adriamycin and anthracenedione mitoxantrone the extent of 3h-thymidine incorporation into the dna was taken as the measure of cytotoxicity . | NA | {
"id": "C0003174",
"name": "anthracenedione",
"pos": [
76,
91
]
} | {
"id": "C0026259",
"name": "mitoxantrone",
"pos": [
92,
104
]
} |
with a view to assess the efficacy of intrathecal pentazocine for post-operative pain relief , 60 patients randomly divided into 6 equal groups were administered graded doses ( 0 , 1 , 2 , 3 , 4 and 5 mg respectively ) of pentazocine lactate , intrathecally along with 1 per cent bupivacaine . | NA | {
"id": "C0030873",
"name": "pentazocine",
"pos": [
50,
61
]
} | {
"id": "C0700554",
"name": "pentazocine lactate",
"pos": [
222,
241
]
} |
arterial plasma kinins and mean arterial pressure were measured in intact and bilaterally nephrectomized rats infused with vehicle or bradykinin to study the role of 1 ) angiotensin converting enzyme ( ace ) and other peptidases and 2 ) the kidney ( a kininase-rich organ ) in the metabolism of kinins in vivo . | NA | {
"id": "C0006100",
"name": "bradykinin",
"pos": [
134,
144
]
} | {
"id": "C0022714",
"name": "kinins",
"pos": [
295,
301
]
} |
it is concluded that , like the other tetracyclines , doxycycline should not be administered together with milk . | NA | {
"id": "C0039651",
"name": "tetracyclines",
"pos": [
38,
51
]
} | {
"id": "C0013090",
"name": "doxycycline",
"pos": [
54,
65
]
} |
the model describes the development of plasma cells and t-helper cells from their precursors through activated and proliferating cells . | NA | {
"id": "C0018956",
"name": "cells",
"pos": [
46,
51
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
129,
134
]
} |
in order to evaluate and compare the efficacy and safety of nifedipine retard and isosorbide-5-mononitrate as monotherapy in the treatment of stable angina , 18 patients with abnormal exercise electrocardiograms and angiographically proven coronary arterial disease were studied in a randomised placebo controlled double... | NA | {
"id": "C0064079",
"name": "isosorbide-5-mononitrate",
"pos": [
82,
106
]
} | {
"id": "C0022251",
"name": "isosorbide",
"pos": [
403,
413
]
} |
the contents of albumin in the lungs were not changed , indicating that captopril did not influence the extravasation of protein . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
16,
23
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
121,
128
]
} |
further studies have shown that , while opportunistic infections and neoplastic complications certainly contribute to the neurological morbidity of aids , the most important neuropathological changes , particularly in the brain , are due to direct hiv infection . | NA | {
"id": "C0001175",
"name": "aids",
"pos": [
148,
152
]
} | {
"id": "C0019693",
"name": "hiv infection",
"pos": [
248,
261
]
} |
supplementing the gluten diet with the essential amino acids l-lysine and l-threonine restored the rejection rate to that of the control rats . | NA | {
"id": "C0002525",
"name": "essential amino acids",
"pos": [
39,
60
]
} | {
"id": "C0040005",
"name": "l-threonine",
"pos": [
74,
85
]
} |
these observations do not support the widely held view that spondylolysis gradually evolves into spondylolisthesis only during childhood or adolescence . | NA | {
"id": "C0038018",
"name": "spondylolysis",
"pos": [
60,
73
]
} | {
"id": "C0038016",
"name": "spondylolisthesis",
"pos": [
97,
114
]
} |
the latter were observed in steel components as well as in those in co-cr alloy . | NA | {
"id": "C0038239",
"name": "steel",
"pos": [
28,
33
]
} | {
"id": "C0002154",
"name": "alloy",
"pos": [
74,
79
]
} |
ethanol or aldehyde fixed muscles were passed to water , postfixed 6-24 h with mercuric acetate ( 5 % w/v in 1 % acetic acid ) , washed with 1 % acetic acid and distilled water , stained 12-24 h at 43 degrees c with ammoniacal silver nitrate ( 60 % w/v ) and washed in 10 % sodium sulfite ( three changes ) and water . | NA | {
"id": "C0790233",
"name": "distilled water",
"pos": [
161,
176
]
} | {
"id": "C0043047",
"name": "water",
"pos": [
311,
316
]
} |
sds-page and western blotting analysis of cultured human embryonal fibroblasts ( wi-38 ) showed that the cells besides tn contain another protein with a molecular weight of 82,000 . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
67,
78
]
} | {
"id": "C0007634",
"name": "the cells",
"pos": [
101,
110
]
} |
simultaneous triple-immunogold staining of virus and host cell antigens with monoclonal antibodies of virus and host cell antigens in ultrathin cryosections . | NA | {
"id": "C0003342",
"name": "antigens",
"pos": [
63,
71
]
} | {
"id": "C0003320",
"name": "antigens",
"pos": [
122,
130
]
} |
moreover , the two soluble b7 forms , which differ only in their alpha 3 domain , are similarly recognized by monoclonal antibodies w6/32 ( anti-hla-abc ) , bbm.1 ( anti-human beta 2 microglobulin ) , and allo-b7-antibody , but differentially recognized by monoclonal antibody q1/28 ( anti-hla class i heavy chain ) . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
213,
221
]
} | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
257,
276
]
} |
we have examined a series of monoclonal antibodies directed against different dq beta alleles carrying the dqw3 specificity to determine subunit and spatial relationship among the epitopes detected by these antibodies . | NA | {
"id": "C0003250",
"name": "monoclonal",
"pos": [
29,
39
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
207,
217
]
} |
monoclonal antibody gil4 directed against an epitope on the platelet membrane glycoprotein ia/iia complex precipitated the same two bands with long-term-activated t lymphocytes , whereas moab ts2/7 directed against very late antigen ( vla ) -1 molecules precipitated two bands with mr 180 and 130 kda ( alpha 1 beta hete... | NA | {
"id": "C0003316",
"name": "epitope",
"pos": [
45,
52
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
225,
232
]
} |
employees with hiv infection or aids should be treated in the same way that any other ill or disabled employee would be treated . | NA | {
"id": "C0019693",
"name": "hiv infection",
"pos": [
15,
28
]
} | {
"id": "C0001175",
"name": "aids",
"pos": [
32,
36
]
} |
all employees should be instructed in basic information regarding hiv infection and aids , so they understand what is and is not a hazard . | NA | {
"id": "C0019693",
"name": "hiv infection",
"pos": [
66,
79
]
} | {
"id": "C0001175",
"name": "aids",
"pos": [
84,
88
]
} |
the technique provides optimal stabilization , can be used in combination with dorsal decompression , and does not require an intact spinous process on the fractured vertebra or attachment of the fixation devices to the fractured vertebra . | NA | {
"id": "C0016658",
"name": "fractured",
"pos": [
156,
165
]
} | {
"id": "C0080179",
"name": "fractured vertebra",
"pos": [
220,
238
]
} |
it is conceivable that the present experiment may serve as a useful model for further studies on inner ear changes related to endolymphatic hydrops and meniere 's disease . | NA | {
"id": "C0206586",
"name": "endolymphatic hydrops",
"pos": [
126,
147
]
} | {
"id": "C0025281",
"name": "meniere 's disease",
"pos": [
152,
170
]
} |
ractopamine appeared to be equipotent to the catecholamine isoproterenol in stimulating basal lipolysis and inhibiting basal lipogenesis , producing maximum effects at 10 ( -6 ) m . | NA | {
"id": "C0007412",
"name": "catecholamine",
"pos": [
45,
58
]
} | {
"id": "C0022245",
"name": "isoproterenol",
"pos": [
59,
72
]
} |
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