text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
the cysts were 83 to 88 % epithelial with the balance of the cells being fibroblastic in appearance . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
61,
66
]
} | {
"id": "C0016030",
"name": "fibroblastic",
"pos": [
73,
85
]
} |
recent studies have revealed that this behavioral difference results from the secretion by fetal fibroblasts of a soluble migration-stimulating factor ( msf ) which acts on these cells in an autocrine fashion . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
97,
108
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
179,
184
]
} |
skin fibroblasts from cancer patients resemble fetal fibroblasts ( rather than normal adult cells ) with respect to their migratory behavior on collagen gels and continued production of msf . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
5,
16
]
} | {
"id": "C0007634",
"name": "normal",
"pos": [
79,
85
]
} |
most often these are manifestations of psychotic illness such as schizophrenia or manic-depressive illness , but they can also be seen in cases of organic mental dysfunction and toxic psychotic states . | NA | {
"id": "C0029227",
"name": "organic mental",
"pos": [
147,
161
]
} | {
"id": "C0004936",
"name": "psychotic",
"pos": [
184,
193
]
} |
the carbohydrate is most likely part of a lipopolysaccharide ( lps ) associated with the csa , because an mab recognizing an o antigen epitope from the lps of m. xanthus also reacted with csa 1604 on western immunoblots . | NA | {
"id": "C0069180",
"name": "o antigen",
"pos": [
125,
134
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
152,
155
]
} |
competitive binding studies verified that mabs 4054 and 1604 identified different epitopes , and mab 4070 probably reacted with a third epitope of the csa 1604 complex . | NA | {
"id": "C0003316",
"name": "epitope",
"pos": [
82,
89
]
} | {
"id": "C0003320",
"name": "csa",
"pos": [
151,
154
]
} |
the drag activity in a. lipoferum was membrane associated , and it catalyzed the activation of inactive nitrogenase ( by covalent modification of dinitrogenase reductase ) from both a. lipoferum and rhodospirillum rubrum . | NA | {
"id": "C0028174",
"name": "nitrogenase",
"pos": [
104,
115
]
} | {
"id": "C0085544",
"name": "dinitrogenase reductase",
"pos": [
146,
169
]
} |
an escherichia coli mutant resistant to phleomycin , bleomycin , and heat inactivation is defective in ubiquinone synthesis . | NA | {
"id": "C0031559",
"name": "phleomycin",
"pos": [
40,
50
]
} | {
"id": "C0005740",
"name": "bleomycin",
"pos": [
53,
62
]
} |
the resistance to phleomycin is strongly dependent on the nature of the c-terminal amine of the drug , with the greatest resistance being shown to phleomycins and bleomycins with the most basic terminal amines . | NA | {
"id": "C0031559",
"name": "phleomycins",
"pos": [
147,
158
]
} | {
"id": "C0005740",
"name": "bleomycins",
"pos": [
163,
173
]
} |
the latter two mutants also lacked o-antigen-containing lipopolysaccharides and induced underdeveloped nodules that lacked nitrogenase activity on bean plants . | NA | {
"id": "C0069180",
"name": "o-antigen",
"pos": [
35,
44
]
} | {
"id": "C0023810",
"name": "lipopolysaccharides",
"pos": [
56,
75
]
} |
the a subunits of the heat-labile enterotoxins also have limited homology with other adp-ribosylating toxins , including pertussis toxin , diphtheria toxin , and pseudomonas aeruginosa exotoxin a . | NA | {
"id": "C0014372",
"name": "enterotoxins",
"pos": [
34,
46
]
} | {
"id": "C0040549",
"name": "toxins",
"pos": [
102,
108
]
} |
purified era-770 mutant protein exhibited reduced binding to gtp compared with that of the wild-type era protein . | NA | {
"id": "C1564139",
"name": "mutant protein",
"pos": [
17,
31
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
105,
112
]
} |
surprisingly , the water-insoluble core of spiralin micelles , which is the putative membrane anchor , has a still more hydrophilic amino acid composition ( mean hydropathy , -0.70 ) and is enriched in glycine and serine residues . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
132,
142
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
202,
209
]
} |
the fluorescence titration curve of skeletal muscle troponin containing tni with 2- [ 4'-iodoacetamido ) anilino ) naphthalene-6-sulfonic acid-labeled cys-48 and/or cys-64 was composed of two transition curves . | NA | {
"id": "C0041199",
"name": "troponin",
"pos": [
52,
60
]
} | {
"id": "C0077401",
"name": "tni",
"pos": [
72,
75
]
} |
these results suggested that human apob-48 is mostly produced by apob mrna with an in-frame stop codon in the intestine . | NA | {
"id": "C0103839",
"name": "apob-48",
"pos": [
35,
42
]
} | {
"id": "C0003593",
"name": "apob",
"pos": [
65,
69
]
} |
the interactions between hydroxyapatite ( hap ) and several types of mucins ( human whole salivary mucins , hwsm ; ovine submandibular mucin , osm ; porcine gastric mucin , pgm ) were compared using a quantitative assay . | NA | {
"id": "C0026682",
"name": "mucin",
"pos": [
69,
74
]
} | {
"id": "C0017135",
"name": "gastric",
"pos": [
157,
164
]
} |
phorbol 12-myristate 13-acetate ( pma ) increases the release of choline , but not pchol , from 1321n1 cells , and down-regulation of protein kinase c blocks the ability of carbachol to stimulate choline production . | NA | {
"id": "C0006945",
"name": "carbachol",
"pos": [
173,
182
]
} | {
"id": "C0008405",
"name": "choline",
"pos": [
196,
203
]
} |
a characteristic signal peptide is present at the amino terminus whose removal is inhibited by the antibiotic , globomycin , suggesting that mature chitobiase is a lipoprotein with a maturation pathway similar to that of the escherichia coli major outer membrane lipoprotein . | NA | {
"id": "C0065058",
"name": "a lipoprotein",
"pos": [
162,
175
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
263,
274
]
} |
the presence of 7-2 rna in nucleoli and in mitochondria suggests that 7-2 ribonucleoproteins , in addition to being essential components of mitochondrial rnase , may also be functional in nucleolar rna processing and ribosome biogenesis . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
20,
23
]
} | {
"id": "C0887909",
"name": "functional",
"pos": [
174,
184
]
} |
in ttt 97 cells , a thyrotropin-producing mouse pituitary tumor , thyroid hormone rapidly inhibits the transcription rate of both the thyrotropin alpha- and beta-subunit ( tsh beta ) genes , and this closely parallels the increase in nuclear thyroid hormone receptor occupancy . | NA | {
"id": "C0040160",
"name": "thyrotropin",
"pos": [
20,
31
]
} | {
"id": "C0076641",
"name": "tsh beta",
"pos": [
172,
180
]
} |
the recombinant flavodoxin protein was found to have an ultraviolet/visible spectrum , amino-terminal sequence , and amino acid composition identical to the wild-type flavodoxin protein purified from clostridium mp . | NA | {
"id": "C0034861",
"name": "recombinant",
"pos": [
4,
15
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
178,
185
]
} |
northern blot analysis in cultured endothelial cells from human umbilical veins shows that ppet-1 mrna is in fact rapidly induced by the active phorbol ester 12-o-tetradecanoylphorbol 13-acetate within 10 min . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
144,
157
]
} | {
"id": "C0039654",
"name": "12-o-tetradecanoylphorbol 13-acetate",
"pos": [
158,
194
]
} |
the parallel effects of the modifications on co-translational translocation and post-translational processing by purified signal peptidase suggest that proteins in the signal peptidase complex might be part of , or intimately associated with , membrane proteins involved in the translocation . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
152,
160
]
} | {
"id": "C0025252",
"name": "membrane proteins",
"pos": [
244,
261
]
} |
the spot gene is deduced to be 702 codons long , with a probable uug initiation codon , and a deduced mass of 79,342 daltons . | NA | {
"id": "C0009221",
"name": "codons",
"pos": [
35,
41
]
} | {
"id": "C0242610",
"name": "initiation codon",
"pos": [
69,
85
]
} |
inhibition kinetics for the interaction of native i alpha i , the inhibitory fragment released by digestion with s. aureus v-8 proteinase , or the related urinary trypsin inhibitor , with seven different proteinases indicated that all had essentially identical ki values with an individual enzyme and , where measurement... | NA | {
"id": "C0030946",
"name": "proteinase",
"pos": [
127,
137
]
} | {
"id": "C0030940",
"name": "proteinases",
"pos": [
204,
215
]
} |
when dna containing a majority of monofunctional platinum-dna lesions was dialyzed against 10 mm nacio4 at 37 degrees c , conversion of monoadducts to bifunctional lesions was observed . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
5,
8
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
173,
174
]
} |
the location of the insert is within a major concavity on the surface of domain i of the exotoxin a molecule , suggesting that this concavity is important for toxin-receptor interaction . | NA | {
"id": "C0015309",
"name": "exotoxin",
"pos": [
89,
97
]
} | {
"id": "C0040549",
"name": "toxin",
"pos": [
159,
164
]
} |
chimeric toxins were made originally by using chemical cross-linking reagents to couple pseudomonas exotoxin ( or other toxins ) to cell-binding proteins . | NA | {
"id": "C0015309",
"name": "exotoxin",
"pos": [
100,
108
]
} | {
"id": "C0040549",
"name": "toxins",
"pos": [
120,
126
]
} |
in the present study we have found that low molecular weight heparin ( lmw-heparin ) preparations obtained by nitrous acid depolymerization or heparinase treatment of standard heparin have different properties with respect to their interaction with the fibrinolytic system . | NA | {
"id": "C0019139",
"name": "low molecular weight",
"pos": [
40,
60
]
} | {
"id": "C0019134",
"name": "heparin",
"pos": [
176,
183
]
} |
a series of 2-unsaturated aldehydes ( acrolein to 2-nonenal ) were all found to modify ldl , but none of these aldehyde-modified ldls were recognized by the scavenger receptor of macrophages and all were degraded much more slowly by these cells than ldl modified with oxidation products . | NA | {
"id": "C0001204",
"name": "acrolein",
"pos": [
38,
46
]
} | {
"id": "C0001992",
"name": "aldehyde",
"pos": [
111,
119
]
} |
only very high concentrations of insulin-like growth factor i and human proinsulin can compete for the insulin receptor binding and suppress hbsag production , this suggests that insulin may act through its receptor binding to suppress hbsag expression in human hepatoma hep3b cells . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
72,
82
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
179,
186
]
} |
l5178y d10/r cells incorporated with an antibody ( mab 3f3 ) known to be a potent inhibitor of tumor asparagine synthetase showed increased dependence on an exogenous source of asparagine in the culture medium , while the growth of cells incorporated with a control ( noninhibitory ) antibody ( mab 2b4 ) remained unaffe... | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
40,
48
]
} | {
"id": "C0003250",
"name": "mab",
"pos": [
295,
298
]
} |
in fibroblasts from individuals with orotic aciduria , these two enzymatic activities are about 1 % of normal but increase dramatically when deficient cells are grown in the presence of 6-azauridine . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
3,
14
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
151,
156
]
} |
in this study , we purified independently sopa and sopb proteins , analyzed the in vitro dna-binding activity of these proteins by the gel retardation assay , and determined the precise binding sites of dna by the footprinting method . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
56,
64
]
} | {
"id": "C0012940",
"name": "dna-binding",
"pos": [
89,
100
]
} |
the ac88 antibody recognizes only free hsp 90 and only bound significant amounts of hsp 90 upon prolonged incubation in the absence of heme or upon n-ethylmaleimide treatment of hemin-supplemented lysates . | NA | {
"id": "C0018966",
"name": "heme",
"pos": [
135,
139
]
} | {
"id": "C0018988",
"name": "hemin",
"pos": [
178,
183
]
} |
upon western blot analysis , heme-deficient lysates were found to have less hsp 90 in the 7.5-8 s region of glycerol gradients than hemin-supplemented lysates . | NA | {
"id": "C0018966",
"name": "heme",
"pos": [
29,
33
]
} | {
"id": "C0018988",
"name": "hemin",
"pos": [
132,
137
]
} |
multiple tachykinins are produced and secreted upon post-translational processing of the three substance p precursor proteins , alpha- , beta- , and gamma-preprotachykinin . | NA | {
"id": "C0039241",
"name": "tachykinins",
"pos": [
9,
20
]
} | {
"id": "C0038585",
"name": "substance p",
"pos": [
95,
106
]
} |
leukocytes contain an enzyme that detoxifies bacterial lipopolysaccharides ( also called endotoxins ) by removing fatty acyl chains that are attached in acyloxy acyl linkage to the glucosamine backbone of lipid a . | NA | {
"id": "C0023810",
"name": "lipopolysaccharides",
"pos": [
55,
74
]
} | {
"id": "C0014264",
"name": "endotoxins",
"pos": [
89,
99
]
} |
leukocytes contain an enzyme that detoxifies bacterial lipopolysaccharides ( also called endotoxins ) by removing fatty acyl chains that are attached in acyloxy acyl linkage to the glucosamine backbone of lipid a . | NA | {
"id": "C0023810",
"name": "lipopolysaccharides",
"pos": [
55,
74
]
} | {
"id": "C0023767",
"name": "lipid a",
"pos": [
205,
212
]
} |
a full length cdna clone encoding the precursor of the rat liver mitochondrial phosphate transporter ( h+/pi symporter ) has been isolated from a cdna library using a bovine heart partial length phosphate transporter clone as a hybridization probe . | NA | {
"id": "C0070775",
"name": "h",
"pos": [
12,
13
]
} | {
"id": "C0890466",
"name": "phosphate transporter",
"pos": [
195,
216
]
} |
hs proteoglycan-i has a mass of approximately kda with a single hs chain ( approximately 12 kda ) and a core protein of approximately 150 kda including oligosaccharides . | NA | {
"id": "C0062503",
"name": "hs proteoglycan",
"pos": [
0,
15
]
} | {
"id": "C0019143",
"name": "hs",
"pos": [
64,
66
]
} |
in the medium with low ionized calcium ( 0.05 mm ) , hs proteoglycan-i is synthesized at approximately 1.6 times the rate and hs proteoglycan-ii at a similar rate as for cells cultured in the medium with high ionized calcium ( 2.1 mm ) . | NA | {
"id": "C0062503",
"name": "hs",
"pos": [
53,
55
]
} | {
"id": "C0019143",
"name": "hs",
"pos": [
126,
128
]
} |
effects of tachykinins and selective tachykinin receptor agonists on vascular permeability in the rat lower urinary tract : evidence for the involvement of nk-1 receptors . | NA | {
"id": "C0075766",
"name": "tachykinin receptor",
"pos": [
37,
56
]
} | {
"id": "C0164209",
"name": "nk-1 receptors",
"pos": [
156,
170
]
} |
intravenous administration of three mammalian tachykinins ( substance p , neurokinin a and neurokinin b ) and three non-mammalian tachykinins ( physalaemin , eledoisin and kassinin ) induced dose-dependent increases in vascular permeability , as measured by evans blue leakage technique , in various segments of the lowe... | NA | {
"id": "C0038585",
"name": "substance p",
"pos": [
60,
71
]
} | {
"id": "C0039241",
"name": "tachykinins",
"pos": [
130,
141
]
} |
intravenous administration of three mammalian tachykinins ( substance p , neurokinin a and neurokinin b ) and three non-mammalian tachykinins ( physalaemin , eledoisin and kassinin ) induced dose-dependent increases in vascular permeability , as measured by evans blue leakage technique , in various segments of the lowe... | NA | {
"id": "C0038581",
"name": "neurokinin a",
"pos": [
74,
86
]
} | {
"id": "C0039241",
"name": "tachykinins",
"pos": [
130,
141
]
} |
intravenous administration of three mammalian tachykinins ( substance p , neurokinin a and neurokinin b ) and three non-mammalian tachykinins ( physalaemin , eledoisin and kassinin ) induced dose-dependent increases in vascular permeability , as measured by evans blue leakage technique , in various segments of the lowe... | NA | {
"id": "C0027847",
"name": "neurokinin b",
"pos": [
91,
103
]
} | {
"id": "C0039241",
"name": "tachykinins",
"pos": [
130,
141
]
} |
intravenous administration of three mammalian tachykinins ( substance p , neurokinin a and neurokinin b ) and three non-mammalian tachykinins ( physalaemin , eledoisin and kassinin ) induced dose-dependent increases in vascular permeability , as measured by evans blue leakage technique , in various segments of the lowe... | NA | {
"id": "C0039241",
"name": "tachykinins",
"pos": [
46,
57
]
} | {
"id": "C0022528",
"name": "kassinin",
"pos": [
172,
180
]
} |
the effects of tachykinin-related peptides which are selective agonists at the nk-1 ( substance p-methylester , [ pro9 ] -sp-sulphone ) , nk-2 receptor [ ( nle10 ] -nka ( 4-10 ] or nk-3 receptor [ ( mephe7 ] -nkb ( 4-10 ) and senktide ) indicated that nk-1 agonists are effective in the whole lower urinary tract , while... | NA | {
"id": "C0039241",
"name": "tachykinin",
"pos": [
15,
25
]
} | {
"id": "C0038585",
"name": "substance",
"pos": [
86,
95
]
} |
fracture comminution and initial displacement , the condition of the fibula and the time from injury to bracing also appeared to affect the speed of union . | NA | {
"id": "C0016658",
"name": "fracture",
"pos": [
0,
8
]
} | {
"id": "C0476171",
"name": "comminution",
"pos": [
9,
20
]
} |
the effects of the aforementioned guanine nucleotides were antagonized by gdp [ s ] , but were insensitive to pertussis toxin . | NA | {
"id": "C0018328",
"name": "guanine nucleotides",
"pos": [
34,
53
]
} | {
"id": "C0018340",
"name": "gdp",
"pos": [
74,
77
]
} |
later analysis of the tapes revealed that particles in cells injected with one of these antibodies ( cg1 , specific for cef tropomyosin isoforms 1 and 3 ) showed a dramatic decrease in instantaneous speed while moving , distance moved per saltation , and proportion of time spent in motion . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
55,
60
]
} | {
"id": "C0016030",
"name": "cef",
"pos": [
120,
123
]
} |
the speed of granule movement in cells injected either with antibody specific for tropomyosin isoforms not present in cef cells , or with cg1 antibody preabsorbed with tropomyosin , was not significantly different from the speed of granules in uninjected cells . | NA | {
"id": "C0016030",
"name": "cef",
"pos": [
118,
121
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
255,
260
]
} |
tau proteins are a class of low molecular mass microtubule-associated proteins that are specifically expressed in the nervous system . | NA | {
"id": "C0085401",
"name": "tau proteins",
"pos": [
0,
12
]
} | {
"id": "C0026045",
"name": "microtubule-associated proteins",
"pos": [
47,
78
]
} |
the presence of apo a-i , cholesterol esters , phospholipids , and triacylglycerols in ultracentrifugal fractions corresponding to serum lipoproteins and the behavior of apo a-i on nondenaturing gradient gels implied that apo a-i was associated with lipid . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
137,
149
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
250,
255
]
} |
the tsp-mediated loss of adhesion plaques was neutralized by the addition of heparin , fucoidan , other heparin-binding proteins , and by a monoclonal antibody to the heparin binding domain of tsp , but not by antibodies to the core or carboxy-terminal regions of tsp . | NA | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
140,
159
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
210,
220
]
} |
cells in the intestinal mucosal layer also appeared to contain high levels of alpha 1 ( xiii ) collagen mrnas , but contained none of the fibrillar collagen mrnas . | NA | {
"id": "C0009325",
"name": "collagen",
"pos": [
95,
103
]
} | {
"id": "C0969669",
"name": "fibrillar collagen",
"pos": [
138,
156
]
} |
these proteins are assayed by the binding of peptide-albumin conjugates to proteins immobilized on nitrocellulose filters . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
53,
60
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
75,
83
]
} |
the data suggest that mouse paw edema resulting from pla2 injection is a multicomponent event , influenced by both autacoids and lipid mediators of inflammation . | NA | {
"id": "C0037343",
"name": "autacoids",
"pos": [
115,
124
]
} | {
"id": "C0243042",
"name": "mediators of inflammation",
"pos": [
135,
160
]
} |
the tumor-promoting phorbol ester , 12-o-tetradecanoyl-phorbol-13-acetate , causes a rapid , partial redistribution of 1,2-diacylglycerol kinase from the cytosol to the particulate fraction of quiescent swiss 3t3 fibroblasts . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
20,
33
]
} | {
"id": "C0039654",
"name": "12-o-tetradecanoyl-phorbol-13-acetate",
"pos": [
36,
73
]
} |
these complications can be broken down into three major categories : the direct effects of ischemia , the effects of myocardial rupture or similar structural loss secondary to ischemic insult , and the effects of inhibitory autonomic reflexes triggered by infarction . | NA | {
"id": "C0022116",
"name": "ischemia",
"pos": [
91,
99
]
} | {
"id": "C0021308",
"name": "infarction",
"pos": [
256,
266
]
} |
to determine whether psychometric scatter is characteristic of the developmental profile of young autistic children , the performance of 38 autistic children , as measured by the cattell , was compared with the performance of ma matched samples of normal , down 's syndrome and non-down 's syndrome children with mental ... | NA | {
"id": "C0728836",
"name": "of",
"pos": [
60,
62
]
} | {
"id": "C0008059",
"name": "children",
"pos": [
299,
307
]
} |
thiotepa dna adducts readily depurinated from dna and were chromatographed and identified by thermospray liquid chromatography-mass spectrometry as the modified bases without the ribose moiety attached . | NA | {
"id": "C0242958",
"name": "dna adducts",
"pos": [
9,
20
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
46,
49
]
} |
thermospray liquid chromatography mass spectrometry ( tsp lc-ms ) was used to characterize products of reactions of these reactive compounds with cysteine or n-acetyl-cysteine . | NA | {
"id": "C0010654",
"name": "cysteine",
"pos": [
146,
154
]
} | {
"id": "C0001047",
"name": "n-acetyl-cysteine",
"pos": [
158,
175
]
} |
solution-phase studies indicate that nucleophilic and electrophilic substitution reactions with purine-6-sulfinate result in the formation of purine , adenine , and hypoxanthine . | NA | {
"id": "C0034140",
"name": "purine",
"pos": [
96,
102
]
} | {
"id": "C0001407",
"name": "adenine",
"pos": [
151,
158
]
} |
the acl were predominantly of the immunoglobulin g isotype and , in a high proportion of cases tested ( 82 % ) , were reactive with other phospholipids , especially those with a negative charge . | NA | {
"id": "C0020852",
"name": "immunoglobulin g",
"pos": [
34,
50
]
} | {
"id": "C0021017",
"name": "isotype",
"pos": [
51,
58
]
} |
to determine whether there was a surface igm- b cell in the tl which could manifest such responses , we compared the frequency of cells expressing the b cell-specific phenotypic marker cd20 ( b1+ ) , surface igm ( sigm+ ) , surface igg ( sigg+ ) , and surface igd ( sigd+ ) in tl and autologous blood mononuclear cells i... | NA | {
"id": "C0007634",
"name": "the",
"pos": [
16,
19
]
} | {
"id": "C1321301",
"name": "blood mononuclear cells",
"pos": [
295,
318
]
} |
evidence for the presence of multiple shared epitopes on the target cellular antigens was found when 290 anti-sm and anti-u1-rnp lupus sera were analyzed by immunoblotting . | NA | {
"id": "C0003316",
"name": "epitopes",
"pos": [
45,
53
]
} | {
"id": "C0003320",
"name": "antigens",
"pos": [
77,
85
]
} |
a sandwich enzyme-linked immunosorbent assay to detect staphylococcal enterotoxin a ( sea ) was developed by using monoclonal antibodies ( mab ) to sea as primary capture antibodies . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
115,
136
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
171,
181
]
} |
a 790-bp hindiii fragment of b. hermsii dna hybridized with dna and whole spirochetes of this species and also with b. parkeri , confirming the close relatedness of these two species . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
0,
1
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
60,
63
]
} |
the amino acids glycine , alanine , serine , threonine , aspartic acid plus asparagine , and glutamic acid plus glutamine constituted 60 to 70 % of the amino acids in both glycopeptides . | NA | {
"id": "C0017890",
"name": "glycine",
"pos": [
16,
23
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
152,
163
]
} |
the amino acids glycine , alanine , serine , threonine , aspartic acid plus asparagine , and glutamic acid plus glutamine constituted 60 to 70 % of the amino acids in both glycopeptides . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
26,
33
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
152,
163
]
} |
the amino acids glycine , alanine , serine , threonine , aspartic acid plus asparagine , and glutamic acid plus glutamine constituted 60 to 70 % of the amino acids in both glycopeptides . | NA | {
"id": "C0061472",
"name": "glutamic acid",
"pos": [
93,
106
]
} | {
"id": "C0017797",
"name": "glutamine",
"pos": [
112,
121
]
} |
the developmental changes in myosin gene expression in the masseter muscle of embryonic and juvenile kittens were examined immunocytochemically using anti-myosin heavy chain antibodies of various specificities . | NA | {
"id": "C0027096",
"name": "myosin",
"pos": [
29,
35
]
} | {
"id": "C0027100",
"name": "myosin heavy chain",
"pos": [
155,
173
]
} |
when gender was considered , 2 items were found to be biased against gifted males , and 2 items also were found to be biased against gifted females . | NA | {
"id": "C0079399",
"name": "gender",
"pos": [
5,
11
]
} | {
"id": "C0086582",
"name": "males",
"pos": [
142,
147
]
} |
this cell type often showed supranuclear lysozyme reactivity and apical neutral mucins , sialomucins , and sulphomucins in variable amounts . | NA | {
"id": "C0026682",
"name": "mucins",
"pos": [
80,
86
]
} | {
"id": "C0074477",
"name": "sialomucins",
"pos": [
89,
100
]
} |
the retrograde and anterograde transport of horseradish peroxidase conjugated to wheat germ agglutinin ( wga-hrp ) has been used to trace afferent connections of the rat mamillary body ( mb ) at the light and electron microscopic levels . | NA | {
"id": "C0019941",
"name": "horseradish peroxidase",
"pos": [
44,
66
]
} | {
"id": "C0078473",
"name": "wga-hrp",
"pos": [
105,
112
]
} |
with the use of individual histologic features , a correlation with specific clinical conditions was possible , and the clinical groups of dermatitis , drug eruption , lupus erythematosus or lichen planus , and t cell infiltration could be selected histologically . | NA | {
"id": "C0011603",
"name": "dermatitis",
"pos": [
139,
149
]
} | {
"id": "C0011609",
"name": "drug eruption",
"pos": [
152,
165
]
} |
the presence of immunoglobulin a ( iga ) and secretory component ( sc ) was investigated in normal human skin and in cutaneous neoplasms including a variety of sweat gland tumors . | NA | {
"id": "C0037286",
"name": "cutaneous neoplasms",
"pos": [
117,
136
]
} | {
"id": "C0038987",
"name": "of sweat gland tumors",
"pos": [
157,
178
]
} |
immunohistochemistry in normal sweat glands revealed the occurrence of secretory iga ( siga ) as indicated by reactivity for iga and sc in serial sections . | NA | {
"id": "C0020838",
"name": "secretory iga",
"pos": [
71,
84
]
} | {
"id": "C0020835",
"name": "iga",
"pos": [
125,
128
]
} |
immunohistochemistry in normal sweat glands revealed the occurrence of secretory iga ( siga ) as indicated by reactivity for iga and sc in serial sections . | NA | {
"id": "C0020838",
"name": "secretory iga",
"pos": [
71,
84
]
} | {
"id": "C0036538",
"name": "sc",
"pos": [
133,
135
]
} |
it was found that both genders used the identity statuses ( process ) comparably , except for foreclosure which characterized males significantly more than females . | NA | {
"id": "C0079399",
"name": "genders",
"pos": [
23,
30
]
} | {
"id": "C0086582",
"name": "males",
"pos": [
158,
163
]
} |
nine of ten reported trials found a numerical advantage for sodium fluoride dentifrices with highly compatible abrasive systems and the hypothesis that these two fluoride agents have equivalent cariostatic effects is rejected ( p = 0.011 ) . | NA | {
"id": "C0037508",
"name": "sodium fluoride",
"pos": [
60,
75
]
} | {
"id": "C0016327",
"name": "fluoride",
"pos": [
162,
170
]
} |
this study determined the effect of brushing with 0.4 % stannous fluoride ( snf2 ) or 0.22 % sodium fluoride ( naf ) on clinical and microbial parameters associated with gingivitis . | NA | {
"id": "C0016327",
"name": "fluoride",
"pos": [
65,
73
]
} | {
"id": "C0037508",
"name": "naf",
"pos": [
111,
114
]
} |
subjects in all three groups were instructed to brush twice daily with an ada-accepted fluoride dentifrice , rinse their mouths with water , and subsequently brush with 0.4 % snf2 , 0.22 % naf , or a fluoridefree placebo gel . | NA | {
"id": "C0016327",
"name": "fluoride",
"pos": [
87,
95
]
} | {
"id": "C0037508",
"name": "naf",
"pos": [
189,
192
]
} |
to determine whether elevated plasma levels of fibrinopeptide a were associated with angina , the plasma levels of fibrinopeptide a were examined during exercise-induced angina in seven additional patients with stable effort angina . | NA | {
"id": "C0002962",
"name": "angina",
"pos": [
85,
91
]
} | {
"id": "C0340288",
"name": "stable",
"pos": [
211,
217
]
} |
to assess the hemodynamic contribution of circulating catecholamines , metyrosine ( alpha-methyl-p-tyrosine ) , an inhibitor of catecholamine synthesis , was administered to nine patients with acutely decompensated chronic congestive heart failure . | NA | {
"id": "C0886584",
"name": "metyrosine",
"pos": [
71,
81
]
} | {
"id": "C0051427",
"name": "alpha-methyl-p-tyrosine",
"pos": [
84,
107
]
} |
the mineralocorticoid effector mechanism of glycyrrhetinic acid and of its ester derivative carbenoxolone was evaluated in human mononuclear leukocytes by radioreceptorassay and measurement of intracellular sodium and potassium after incubation of the cells with or without the drugs . | NA | {
"id": "C0017986",
"name": "glycyrrhetinic acid",
"pos": [
44,
63
]
} | {
"id": "C0006979",
"name": "carbenoxolone",
"pos": [
92,
105
]
} |
the mean intracellular content of sodium in mononuclear leukocytes from 7 volunteers was 35 % higher ( p less than 0.05 ) after incubation with 3 mumol glycyrrhetinic acid than after incubation with an equivalent amount of carbenoxolone , or in medium alone . | NA | {
"id": "C0017986",
"name": "glycyrrhetinic acid",
"pos": [
152,
171
]
} | {
"id": "C0006979",
"name": "carbenoxolone",
"pos": [
223,
236
]
} |
we conclude that the syndrome of pseudohyperaldosteronism from carbenoxolone is thus probably not related to a direct agonist effect of the drug at the level of mineralocorticoid receptors , but that any action must follow in vivo conversion into glycyrrhetinic acid by hydrolysis . | NA | {
"id": "C0006979",
"name": "carbenoxolone",
"pos": [
63,
76
]
} | {
"id": "C0017986",
"name": "glycyrrhetinic acid",
"pos": [
247,
266
]
} |
carbenoxolone is a derivative of glycyrrhetinic acid used for the treatment of peptic ulcer and gastritis , with salt and water retention a very common side-effect . | NA | {
"id": "C0006979",
"name": "carbenoxolone",
"pos": [
0,
13
]
} | {
"id": "C0017986",
"name": "glycyrrhetinic acid",
"pos": [
33,
52
]
} |
fischer 344 rats at various ages throughout the life span have been treated with growth hormone , clonidine , and insulin-like growth factor-i to restore circulating somatomedin levels in old animals to levels found in younger rats . | NA | {
"id": "C0021665",
"name": "insulin-like growth factor-i",
"pos": [
114,
142
]
} | {
"id": "C0037657",
"name": "somatomedin",
"pos": [
166,
177
]
} |
incubation in vitro of cells from both groups with catecholamines , at concentrations comparable to those achieved in plasma after standing , resulted in enhanced isoproterenol-mediated camp responses , but no change in beta-adrenergic receptor density . | NA | {
"id": "C0007412",
"name": "catecholamines",
"pos": [
51,
65
]
} | {
"id": "C0022245",
"name": "isoproterenol",
"pos": [
163,
176
]
} |
a muscle biopsy examined by light microscopic , histochemical , and electron microscopic techniques exhibited changes of muscle phosphorylase deficiency and glycogenosis , identical to those of mcardle 's disease . | NA | {
"id": "C0017919",
"name": "glycogenosis",
"pos": [
157,
169
]
} | {
"id": "C0017924",
"name": "mcardle 's disease",
"pos": [
194,
212
]
} |
the addition of human or rat serum albumin to the infusate , at an albumin : taurocholate molar ratio equal to or above 200 , completely prevented haemolysis and the above-mentioned alterations in bilirubin transport , without any change in the bile acid output . | NA | {
"id": "C0304925",
"name": "human",
"pos": [
16,
21
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
67,
74
]
} |
placental transfer of cadmium , lead and mercury was studied under the conditions of environmental exposures of pregnant women to these heavy metals . | NA | {
"id": "C0006632",
"name": "cadmium",
"pos": [
22,
29
]
} | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
136,
148
]
} |
placental transfer of cadmium , lead and mercury was studied under the conditions of environmental exposures of pregnant women to these heavy metals . | NA | {
"id": "C0023175",
"name": "lead",
"pos": [
32,
36
]
} | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
136,
148
]
} |
placental transfer of cadmium , lead and mercury was studied under the conditions of environmental exposures of pregnant women to these heavy metals . | NA | {
"id": "C0025424",
"name": "mercury",
"pos": [
41,
48
]
} | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
136,
148
]
} |
the magnetic field of 0.008 t and 0.15 t inductions influence lasting 7 weeks ( 7 days a week ) , 1 h daily determines the increase of the activity of cytoplasmatic enzymes ( glutamic pyruvic transaminase , glutamic oxalacetic transaminase , lactic dehydrogenase ) , the decrease of cholinesterase activity and the growt... | NA | {
"id": "C0001899",
"name": "glutamic pyruvic transaminase",
"pos": [
175,
204
]
} | {
"id": "C0002594",
"name": "transaminase",
"pos": [
227,
239
]
} |
it has been shown that in spite of general low incidence rate of m. bovis infections in human population there are regions with high level of cattle raising ( kazakh ssr , novosibirsk region of the rsfsr ) where both the infection rate and morbidity rate due to this agent are much higher . | NA | {
"id": "C0243026",
"name": "general",
"pos": [
35,
42
]
} | {
"id": "C0009450",
"name": "infection",
"pos": [
221,
230
]
} |
the author underlines the fact that transmission of m. bovis from man to man is practically very rare and therefore this type of tuberculosis in human population is not autonomous and disappears as soon as the tuberculosis of cattle is irradicated . | NA | {
"id": "C0041296",
"name": "tuberculosis",
"pos": [
129,
141
]
} | {
"id": "C0041307",
"name": "tuberculosis",
"pos": [
210,
222
]
} |
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