text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
this was accompanied by a reduction of fluid intake and an increase of circulating antidiuretic hormone ( arginine vasopressin ; avp ) . | NA | {
"id": "C0042413",
"name": "antidiuretic hormone",
"pos": [
83,
103
]
} | {
"id": "C0003779",
"name": "arginine",
"pos": [
106,
114
]
} |
incubation at 37 degrees c of the ang i immunoreactive material with plasma partially destroyed the angiotensin immunoreactive material . | NA | {
"id": "C0003006",
"name": "ang i",
"pos": [
34,
39
]
} | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
100,
111
]
} |
these findings demonstrated that the angiotensin immunoreactive material was an ang i containing tetradecapeptide ( tdp ) -like peptide , unstable during a renin incubation step , leading to erroneous values for plasma inactive renin if not removed . | NA | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
37,
48
]
} | {
"id": "C0003006",
"name": "ang i",
"pos": [
80,
85
]
} |
we investigated the effects of the retinoids , all-trans retinoic acid ( t-ra ) , 13-cis retinoic acid , etretinate , and arotinoid ethyl ester , on 12-o-tetradecanoyl-phorbol-13-acetate ( tpa ) -induced dna synthesis , and epidermal hyperplasia in hairless mouse skin . | NA | {
"id": "C0035339",
"name": "retinoids",
"pos": [
35,
44
]
} | {
"id": "C0022265",
"name": "13-cis retinoic acid",
"pos": [
82,
102
]
} |
heated murine bacillus calmette-guerin-activated macrophages retained their cytotoxic activities better in coculture with unheated tumour cells if triggering with the endotoxin lipopolysaccharide preceded 1 h of heating at 42 or 43 degrees c than they did if heating to the same extent was concomitant with , or preceded... | NA | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
167,
176
]
} | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
177,
195
]
} |
2 ) the effectors in this assay established in our laboratory were the cells nonadherent on plastics and nylon wool , suggesting t lymphocytes and donor specificity was confirmed by cold competition . | NA | {
"id": "C0032167",
"name": "plastics",
"pos": [
92,
100
]
} | {
"id": "C0028736",
"name": "nylon",
"pos": [
105,
110
]
} |
the catecholamine used was dopamine ( 5-15 gamma ; da group ) , dobutamine ( 5-15 gamma ; dob group ) , noradrenaline ( 0.5-1.5 gamma ; nad group ) and adrenaline ( 0.5-1.5 gamma , ad group ) . | NA | {
"id": "C0007412",
"name": "catecholamine",
"pos": [
4,
17
]
} | {
"id": "C0012963",
"name": "dobutamine",
"pos": [
64,
74
]
} |
the catecholamine used was dopamine ( 5-15 gamma ; da group ) , dobutamine ( 5-15 gamma ; dob group ) , noradrenaline ( 0.5-1.5 gamma ; nad group ) and adrenaline ( 0.5-1.5 gamma , ad group ) . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
104,
117
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
152,
162
]
} |
these findings suggest that the lower mortality of modified group is due to better left ventricular function preventing los in the early postoperative period , and that preserving the posterior mitral apparatus has a more beneficial effect on postoperative left ventricular function even in combined valve disease . | NA | {
"id": "C0039082",
"name": "los",
"pos": [
120,
123
]
} | {
"id": "C0012634",
"name": "disease",
"pos": [
306,
313
]
} |
furthermore , regurgitant murmur , arrythmia ( atrial fibrillation ) and cardiac enlargement were followed in addition to rumbling murmur . | NA | {
"id": "C0003811",
"name": "arrythmia",
"pos": [
35,
44
]
} | {
"id": "C0004238",
"name": "atrial fibrillation",
"pos": [
47,
66
]
} |
the tumor was extirpated and the specimen was revealed to be multiple thymic cyst with papillo-tubular adenocarcinoma proliferating in one of the cysts . | NA | {
"id": "C0027651",
"name": "tumor",
"pos": [
4,
9
]
} | {
"id": "C0010709",
"name": "cysts",
"pos": [
146,
151
]
} |
anti-xa and anti-iia heparin activities were monitored together with aptt , thrombin time , bleeding time and euglobulin lysis time . | NA | {
"id": "C0019139",
"name": "anti-xa",
"pos": [
0,
7
]
} | {
"id": "C0019134",
"name": "heparin",
"pos": [
21,
28
]
} |
gnrh-a ( buserelin ) was infused continuously through the subcutaneous route at rates of 200 micrograms ( group i ; n = 5 ) , 100 micrograms ( group ii , n = 4 ) and 10 micrograms ( group iii ; n = 4 ) per day for 24 weeks . | NA | {
"id": "C0023610",
"name": "gnrh",
"pos": [
0,
4
]
} | {
"id": "C0006456",
"name": "buserelin",
"pos": [
9,
18
]
} |
aluminum solubility did not change with a change in ph for the citrate compounds , which varied between 38 % , with sucralfate plus citric acid , and 91 % , with aluminum citrate . | NA | {
"id": "C0008857",
"name": "citrate",
"pos": [
63,
70
]
} | {
"id": "C0055819",
"name": "citric acid",
"pos": [
132,
143
]
} |
the fraction of the administered dose of aluminum absorbed as estimated by urinary excretion after gastric gavage was 0.015 % for sucralfate and al ( oh ) 3 , 0.037 % for alcl3 and aluminum lactate , and greater than 0.80 % for all aluminum compounds administered with citrate . | NA | {
"id": "C0102840",
"name": "alcl3",
"pos": [
171,
176
]
} | {
"id": "C0206103",
"name": "aluminum compounds",
"pos": [
232,
250
]
} |
plasma dihydroxyphenylalanine ( dopa ) has been shown to originate in sympathetic neurons , and it has been suggested that plasma level reflects activity of tyrosine hydroxylase , the rate-limiting enzyme in the synthesis of catecholamines . | NA | {
"id": "C0013023",
"name": "dihydroxyphenylalanine",
"pos": [
7,
29
]
} | {
"id": "C0007412",
"name": "catecholamines",
"pos": [
225,
239
]
} |
in this study , we measured the effects of acute exercise and exercise training on the levels of dopa and catecholamines in the plasma of healthy , older individuals . | NA | {
"id": "C0013023",
"name": "dopa",
"pos": [
97,
101
]
} | {
"id": "C0007412",
"name": "catecholamines",
"pos": [
106,
120
]
} |
levels of dopa and catecholamines in plasma samples were measured by high-performance liquid chromatography with electrochemical detection . | NA | {
"id": "C0013023",
"name": "dopa",
"pos": [
10,
14
]
} | {
"id": "C0007412",
"name": "catecholamines",
"pos": [
19,
33
]
} |
the absolute increase in dopa was greater than the increase in epinephrine or dopamine but was not greater than that in norepinephrine . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
63,
74
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
120,
134
]
} |
the apoa-i/a-ii ratio was elevated only in women with high hdl-cholesterol but not in men , suggesting that elevation of apoa-i is involved in hyperalphalipoproteinemia in females , whereas both apoa proteins are elevated in men with high hdl cholesterol . | NA | {
"id": "C0085201",
"name": "apoa-i",
"pos": [
4,
10
]
} | {
"id": "C0003592",
"name": "apoa",
"pos": [
195,
199
]
} |
the hl activity was reduced in the high hdl-cholesterol group ( 21.2 +/- 1.5 vs. 38.5 +/- 1.8 mumol/h/ml , p less than 0.001 ) , whereas the lpl activity was elevated in the group with high hdl-cholesterol compared to subjects with low hdl-cholesterol ( 27.8 +/- 1.3 vs. 19.9 +/- 0.8 mumol/h/ml , p less than 0.001 ) . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
44,
55
]
} | {
"id": "C0023822",
"name": "high hdl-cholesterol",
"pos": [
185,
205
]
} |
we then determined the mean hydrophilic-hydrophobic balance ( hydrophobicity index ) of the bile salts in bile , and correlated this with the specific activities of c7 alpha h and hmg-coa-r , and of acyl-coa : cholesterol acyltransferase ( acat ) , a third hepatic microsomal enzyme which regulates cholesterol esterific... | NA | {
"id": "C0009226",
"name": "hmg-coa-r",
"pos": [
180,
189
]
} | {
"id": "C0001374",
"name": "acyl-coa",
"pos": [
199,
207
]
} |
intrahepatic assembly of very low density lipoproteins : immunologic characterization of apolipoprotein b in lipoproteins and hepatic membrane fractions and its intracellular distribution . | NA | {
"id": "C0023825",
"name": "very low density lipoproteins",
"pos": [
25,
54
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
109,
121
]
} |
while fasting rates of esterification and transfer increased as a result of diet-induced hypercholesterolemia , the postprandial response was reversed , so that postprandial metabolism was characterized by a movement of cholesterol from plasma to blood cells , an inhibition of cholesterol esterification , and a net tra... | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
94,
105
]
} | {
"id": "C0008387",
"name": "cholesteryl esters",
"pos": [
329,
347
]
} |
taken together , our data demonstrate that smc metabolism of cldl leads to cholesterol and ce accretion concomitant with diminished production of eicosanoids . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
75,
86
]
} | {
"id": "C0008387",
"name": "ce",
"pos": [
91,
93
]
} |
of these unusual 3 beta-hydroxy-5-en-metabolites , delta 5-3 beta-ol and delta 5-3 beta,12 alpha-ol were found as major components in the urine of patients with liver diseases ( cholestasis , liver cirrhosis , chronic hepatitis , acute hepatitis ) . | NA | {
"id": "C0023895",
"name": "liver diseases",
"pos": [
161,
175
]
} | {
"id": "C0023890",
"name": "liver cirrhosis",
"pos": [
192,
207
]
} |
plasma lipoprotein metabolism in lean and in fat chickens produced by divergent selection for plasma very low density lipoprotein concentration . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
7,
18
]
} | {
"id": "C0023825",
"name": "very low density lipoprotein",
"pos": [
101,
129
]
} |
plasma lipoprotein metabolism was studied in vivo in two lines of chickens produced by selection for high and low plasma very low density lipoprotein ( vldl ) concentration . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
7,
18
]
} | {
"id": "C0023825",
"name": "very low density lipoprotein",
"pos": [
121,
149
]
} |
the specific activities of fatty acid coa ligase , diacylglycerol acyltransferase , and microsomal and mitochondrial glycerol-p acyltransferases changed comparatively little during this time period . | NA | {
"id": "C0163260",
"name": "diacylglycerol acyltransferase",
"pos": [
51,
81
]
} | {
"id": "C0001390",
"name": "acyltransferases",
"pos": [
128,
144
]
} |
the neurohypophysial hormone antagonist analogues , [ d ( ch2 ) 5tyr ( me ) 2 ] vasopressin , [ d ( ch2 ) 5tyr ( me ) 2 , orn8 ] vasotocin and [ d ( ch2 ) 5d-tyr ( et ) 2val4 , cit8 ] vasopressin , inhibited the lh response to both oxytocin and vasopressin . | NA | {
"id": "C0032017",
"name": "neurohypophysial hormone",
"pos": [
4,
28
]
} | {
"id": "C0042418",
"name": "vasotocin",
"pos": [
129,
138
]
} |
the neurohypophysial hormone antagonist analogues , [ d ( ch2 ) 5tyr ( me ) 2 ] vasopressin , [ d ( ch2 ) 5tyr ( me ) 2 , orn8 ] vasotocin and [ d ( ch2 ) 5d-tyr ( et ) 2val4 , cit8 ] vasopressin , inhibited the lh response to both oxytocin and vasopressin . | NA | {
"id": "C0032017",
"name": "neurohypophysial hormone",
"pos": [
4,
28
]
} | {
"id": "C0030095",
"name": "oxytocin",
"pos": [
232,
240
]
} |
an increase in myocardial beta mhc mrna was demonstrated in hypothyroidism , accompanied by a reduction in alpha mhc mrna . | NA | {
"id": "C0027100",
"name": "mhc",
"pos": [
31,
34
]
} | {
"id": "C0027096",
"name": "mhc",
"pos": [
113,
116
]
} |
treatment of animals with the biguanide drug metformin ( n ' , n'-dimethylbiguanide ) decreased the ability of glucagon to stimulate this enzyme to some 16-fold for both the lean and obese animals and reduced the ka values for activation of this enzyme by glucagon to 6.3 and 60.9 nmol/l respectively . | NA | {
"id": "C0005382",
"name": "biguanide",
"pos": [
30,
39
]
} | {
"id": "C0025598",
"name": "metformin",
"pos": [
45,
54
]
} |
since ca2+ influx was already activated at a calculated membrane potential below -70 mv , and was found to be sensitive to the dihydropyridine antagonist nifedipine ( 1 mumol/l ) , but insensitive to nickel ions ( 100 mumol/l ) , it does not meet the criteria established for t- or l-type voltage-dependent ca2+ channels... | NA | {
"id": "C0012315",
"name": "dihydropyridine",
"pos": [
127,
142
]
} | {
"id": "C0028066",
"name": "nifedipine",
"pos": [
154,
164
]
} |
some , though not all , previous studies have suggested that the inositol lipid which is hydrolysed during transmembrane signalling in response to receptor activation might be drawn from a metabolically discrete and relatively small hormone-sensitive lipid pool that turns over more rapidly than the bulk of membrane ino... | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
74,
79
]
} | {
"id": "C0025249",
"name": "membrane",
"pos": [
308,
316
]
} |
we anticipated that stimulation of these doubly labelled cells might provoke the formation , from the postulated hormone-sensitive pool , of small quantities of relatively 3h-enriched inositol phosphates , and that these could be harvested from cells ( provided that the cytosolic inositol monophosphatase and inositol 1... | NA | {
"id": "C0021554",
"name": "inositol phosphates",
"pos": [
184,
203
]
} | {
"id": "C0021547",
"name": "inositol",
"pos": [
336,
344
]
} |
there was a tendency for phosphatidyl-inositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate to have slightly higher 3h : 14c ratios than phosphatidylinositol , but the 3h : 14c ratios of the inositol phosphates formed in stimulated cells were not substantially greater than the 3h : 14c ratios of the inositol l... | NA | {
"id": "C0021554",
"name": "inositol phosphates",
"pos": [
200,
219
]
} | {
"id": "C0021547",
"name": "inositol",
"pos": [
310,
318
]
} |
growth hormone has been reported to exert direct effects on rat and rabbit epiphyseal chondrocytes in vitro , indicating that gh interacts with specific receptors on these cells . | NA | {
"id": "C0225369",
"name": "chondrocytes",
"pos": [
86,
98
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
172,
177
]
} |
we have determined the factors that control release of igf-bp from monolayers of human fetal fibroblasts using a radioimmunoassay , and have compared this with the effects of these factors on the release of igf-i and -ii . | NA | {
"id": "C0037657",
"name": "igf",
"pos": [
55,
58
]
} | {
"id": "C0021665",
"name": "igf-i",
"pos": [
207,
212
]
} |
the 30 kda igf-bp was released in parallel with radioimmunoassayable igf-i and -ii over 48 h . | NA | {
"id": "C0037657",
"name": "igf",
"pos": [
11,
14
]
} | {
"id": "C0021665",
"name": "igf-i",
"pos": [
69,
74
]
} |
however , a significant inverse correlation was found between the release of igf-bp , igf-i , igf-ii and cell density . | NA | {
"id": "C0037657",
"name": "igf",
"pos": [
77,
80
]
} | {
"id": "C0021665",
"name": "igf-i",
"pos": [
94,
99
]
} |
however , a significant inverse correlation was found between the release of igf-bp , igf-i , igf-ii and cell density . | NA | {
"id": "C0037657",
"name": "igf",
"pos": [
77,
80
]
} | {
"id": "C0021666",
"name": "igf-ii",
"pos": [
94,
100
]
} |
the exposure of fibroblasts to 1.3 nmol/l or greater of igf-i or -ii caused a significant release of igf-bp . | NA | {
"id": "C0021665",
"name": "igf-i",
"pos": [
56,
61
]
} | {
"id": "C0037657",
"name": "igf",
"pos": [
101,
104
]
} |
igf-i and -ii were approximately equipotent with a fourfold increase in igf-bp release at 19.7 nmol/l . | NA | {
"id": "C0021665",
"name": "igf-i",
"pos": [
0,
5
]
} | {
"id": "C0037657",
"name": "igf",
"pos": [
72,
75
]
} |
insulin caused a release of igf-bp and igf-i and -ii from fibroblasts at supraphysiological concentrations ( 16.7 nmol/l ) which again was maximal on sparse cell cultures . | NA | {
"id": "C0037657",
"name": "igf",
"pos": [
28,
31
]
} | {
"id": "C0021665",
"name": "igf-i",
"pos": [
39,
44
]
} |
increases in igf-bp , igf-i and -ii release were also found in the presence of human placental lactogen ( 23.3 nmol/l ) , but human gh , epidermal growth factor , fibroblast growth factor and platelet-derived growth factor were without effect . | NA | {
"id": "C0037657",
"name": "igf",
"pos": [
13,
16
]
} | {
"id": "C0021665",
"name": "igf-i",
"pos": [
22,
27
]
} |
the results show that human fetal fibroblasts released an igf-bp immunologically similar to that seen in amniotic fluid together with igf-i and -ii , that igf-bp release was enhanced by exogenous addition of igf peptides , and that the release of all three peptides was a property of sparsely plated , rapidly growing ce... | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
34,
45
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
318,
323
]
} |
the results show that human fetal fibroblasts released an igf-bp immunologically similar to that seen in amniotic fluid together with igf-i and -ii , that igf-bp release was enhanced by exogenous addition of igf peptides , and that the release of all three peptides was a property of sparsely plated , rapidly growing ce... | NA | {
"id": "C0021665",
"name": "igf-i",
"pos": [
134,
139
]
} | {
"id": "C0037657",
"name": "igf",
"pos": [
208,
211
]
} |
neurohypophysial hormones have been implicated in the control of anterior pituitary function , and oxytocin has been shown to stimulate gonadotrophin excretion and ovarian follicular development in certain species . | NA | {
"id": "C0032017",
"name": "neurohypophysial hormones",
"pos": [
0,
25
]
} | {
"id": "C0030095",
"name": "oxytocin",
"pos": [
99,
107
]
} |
the gonadotrophin responses to oxytocin and vasopressin were inhibited by the specific neurohypophysial hormone antagonists , [ d ( ch2 ) 5d-ile2 , ile4 , arg8 ] vasopressin and [ d ( ch2 ) 5tyr ( me ) , arg8 ] vasopressin . | NA | {
"id": "C0030095",
"name": "oxytocin",
"pos": [
31,
39
]
} | {
"id": "C0032017",
"name": "neurohypophysial hormone",
"pos": [
87,
111
]
} |
prolactin , gh , tsh , adrenaline and noradrenaline responses to the stress of immobilization were compared between lactating and non-lactating dioestrous rats . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
23,
33
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
38,
51
]
} |
the increases in plasma concentrations of adrenaline and noradrenaline induced by stress were significantly smaller in lactating than in non-lactating rats . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
42,
52
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
57,
70
]
} |
producer cells demonstrating this response were found to be primarily localized to the rosette e- ( leu 11+ ) fraction of pbmc and appear to be of the lgl/nk variety . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
9,
14
]
} | {
"id": "C1321301",
"name": "pbmc",
"pos": [
122,
126
]
} |
cd59 antigen was purified from human urine and erythrocyte stroma by affinity chromatography using the mab yth 53.1 immobilized on sepharose , and , following transient expression of a human t cell cdna library in cos cells , the corresponding cdna also identified using the antibody . | NA | {
"id": "C0003250",
"name": "mab",
"pos": [
103,
106
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
275,
283
]
} |
hyperimmunoglobulinemia was found in 50-60 % of all 3 grades of lymphoma , monoclonal gammopathy in 3 cases of ig lymphoma , and hypercalcemia in 4 cases of ig and hg lymphomas . | NA | {
"id": "C0020455",
"name": "hyperimmunoglobulinemia",
"pos": [
0,
23
]
} | {
"id": "C0026470",
"name": "monoclonal gammopathy",
"pos": [
75,
96
]
} |
in conclusion , the characteristic features of nhl in taiwan include : ( 1 ) a high proportion of hg lymphoma and low proportions of lg and follicular lymphomas ; | NA | {
"id": "C0024305",
"name": "nhl",
"pos": [
47,
50
]
} | {
"id": "C0024301",
"name": "follicular lymphomas",
"pos": [
140,
160
]
} |
most clinically euthyroid patients with acute or chronic nonthyroid illness have abnormal thyroid function which is called the euthyroid sick syndrome . | NA | {
"id": "C0040128",
"name": "abnormal thyroid",
"pos": [
81,
97
]
} | {
"id": "C0015190",
"name": "euthyroid sick syndrome",
"pos": [
127,
150
]
} |
we have investigated the modulation of l-type calcium channel currents in isolated ventricular cells by the dihydropyridine derivative amlodipine , a weak base with a pka of 8.6 . | NA | {
"id": "C0012315",
"name": "dihydropyridine",
"pos": [
108,
123
]
} | {
"id": "C0051696",
"name": "amlodipine",
"pos": [
135,
145
]
} |
although this 95 amino acid antigenic domain appeared to be capable of forming several conformational neutralizing epitopes , it was not an effective immunogen for inducing neutralizing or protective antibodies in mice . | NA | {
"id": "C0003316",
"name": "epitopes",
"pos": [
115,
123
]
} | {
"id": "C0003320",
"name": "immunogen",
"pos": [
150,
159
]
} |
five of them corresponded in size and location to rabies virus mrnas , and one of particular interest corresponded to a bicistronic rna which included the genes for the phosphoprotein and the matrix protein . | NA | {
"id": "C0031689",
"name": "phosphoprotein",
"pos": [
169,
183
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
199,
206
]
} |
we have used these antibodies and immune cat serum in immunoprecipitation and western blotting experiments and have identified novel proteins in fcv-infected cells which we term p78 , p41 , p35 and p29 . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
19,
29
]
} | {
"id": "C0020960",
"name": "immune",
"pos": [
34,
40
]
} |
major and minor pathways of metabolism in the mammalian cns result in the formation of 3-methoxy-4-hydroxyphenylethylene glycol ( mhpg ) and normetanephrine ( nmn ) from norepinephrine ( ne ) , and homovanillic acid ( hva ) and 3-methoxytyramine ( 3-mt ) from dopamine ( da ) , respectively . | NA | {
"id": "C0028385",
"name": "normetanephrine",
"pos": [
141,
156
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
170,
184
]
} |
for the ne metabolites , significant correlations were obtained for csf mhpg and nmn ( r = 0.806 , p less than 0.001 ) , plasma mhpg and csf nmn ( r = 0.753 , p less than 0.001 ) , and plasma and csf mhpg ( r = 0.776 , p less than 0.001 ) . | NA | {
"id": "C0028351",
"name": "ne",
"pos": [
8,
10
]
} | {
"id": "C0028385",
"name": "nmn",
"pos": [
141,
144
]
} |
the results for the da metabolites probably reflect regional differences in steady-state brain dopaminergic metabolism . | NA | {
"id": "C0013030",
"name": "da",
"pos": [
20,
22
]
} | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
95,
107
]
} |
the binding of the dihydropyridine [ 3h ] nitrendipine defined a single specific binding site with a kd of 490 pm and a bmax of 129 fmol/mg of protein . | NA | {
"id": "C0012315",
"name": "dihydropyridine",
"pos": [
19,
34
]
} | {
"id": "C0028127",
"name": "nitrendipine",
"pos": [
42,
54
]
} |
the ability of guanine nucleotides ( 0.4 mm gtp or 0.1 mm 5'-guanylylimidodiphosphate ) to provoke a conversion of rh into rl was different between these brain regions . | NA | {
"id": "C0018328",
"name": "guanine",
"pos": [
15,
22
]
} | {
"id": "C0018353",
"name": "gtp",
"pos": [
44,
47
]
} |
the ability of guanine nucleotides ( 0.4 mm gtp or 0.1 mm 5'-guanylylimidodiphosphate ) to provoke a conversion of rh into rl was different between these brain regions . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
44,
47
]
} | {
"id": "C0018366",
"name": "guanylylimidodiphosphate",
"pos": [
61,
85
]
} |
pretreatment of the neurones with either dibutyryl cgmp or sodium nitroprusside ( which elevates cgmp ) inhibited bradykinin-induced formation of inositol phosphates . | NA | {
"id": "C0012055",
"name": "dibutyryl cgmp",
"pos": [
41,
55
]
} | {
"id": "C0018338",
"name": "cgmp",
"pos": [
97,
101
]
} |
examination of the time course of accumulation of the individual inositol phosphates stimulated by histamine revealed an early and sustained rise in inositol 1,4-bisphosphate content but not inositol 1,4,5-trisphosphate content at 1 min and the overall largest accumulation of inositol monophosphate after 30 min of stim... | NA | {
"id": "C0021554",
"name": "inositol phosphates",
"pos": [
65,
84
]
} | {
"id": "C0021547",
"name": "inositol",
"pos": [
277,
285
]
} |
in this inhibitory action , pma exhibited high potency ( ic50 of approximately 0.5 nm ) , an effect not shared by the inactive phorbol ester 4-alpha-phorbol 12,13-didecanoate . | NA | {
"id": "C0039654",
"name": "pma",
"pos": [
28,
31
]
} | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
127,
140
]
} |
studies were conducted to determine the effect of pma on protein phosphorylation in astrocytes and to compare this pattern of phosphorylation with that elicited by dibutyryl cyclic amp ( dbcamp ) , an activator of the cyclic amp-dependent protein kinase which also affects astrocyte morphology . | NA | {
"id": "C0012054",
"name": "dibutyryl cyclic amp",
"pos": [
164,
184
]
} | {
"id": "C0001455",
"name": "cyclic amp",
"pos": [
218,
228
]
} |
exposure to pma increased the amount of 32p incorporation into several phosphoproteins , including two cytosolic proteins with molecular weights of 30,000 ( pi 5.5 and 5.7 ) , an acidic 80,000 molecular weight protein ( pi 4.5 ) present in both the cytosolic and membrane fractions , and two cytoskeletal proteins with m... | NA | {
"id": "C0031689",
"name": "phosphoproteins",
"pos": [
71,
86
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
433,
440
]
} |
exposure to pma increased the amount of 32p incorporation into several phosphoproteins , including two cytosolic proteins with molecular weights of 30,000 ( pi 5.5 and 5.7 ) , an acidic 80,000 molecular weight protein ( pi 4.5 ) present in both the cytosolic and membrane fractions , and two cytoskeletal proteins with m... | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
78,
85
]
} | {
"id": "C0010852",
"name": "cytoskeletal proteins",
"pos": [
292,
313
]
} |
thymopoietin did not inhibit the binding of other radioligands known to interact with different populations of cholinergic receptors , such as [ 3h ] nicotine and [ 3h ] methylcarbachol , which bind to nicotinic receptors , or [ 3h ] quinuclidinylbenzilate , which binds to muscarinic receptors . | NA | {
"id": "C0034792",
"name": "cholinergic receptors",
"pos": [
111,
132
]
} | {
"id": "C0034830",
"name": "nicotinic receptors",
"pos": [
202,
221
]
} |
thymopoietin did not inhibit the binding of other radioligands known to interact with different populations of cholinergic receptors , such as [ 3h ] nicotine and [ 3h ] methylcarbachol , which bind to nicotinic receptors , or [ 3h ] quinuclidinylbenzilate , which binds to muscarinic receptors . | NA | {
"id": "C0034792",
"name": "cholinergic receptors",
"pos": [
111,
132
]
} | {
"id": "C0034826",
"name": "muscarinic receptors",
"pos": [
274,
294
]
} |
acute and chronic relapsing axonal polyradiculoneuropathies appear to be two clinical forms of a peculiar entity different from gbs . | NA | {
"id": "C0032587",
"name": "polyradiculoneuropathies",
"pos": [
35,
59
]
} | {
"id": "C0018378",
"name": "gbs",
"pos": [
128,
131
]
} |
models based on experimentally induced disease , include heavy metals and trace elements ( lead intoxication in guinea pigs , rabbits , rats , cats and primates ; mercury intoxication in rats ; aluminium intoxication in rabbits ; swayback in goat kids ; calcium and magnesium deficient rabbits and primates and calcium d... | NA | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
57,
69
]
} | {
"id": "C0025424",
"name": "mercury",
"pos": [
163,
170
]
} |
norepinephrine , epinephrine , dopamine , serotonin and their major metabolites were measured in 20 regions of the left hemisphere in 4 presenile familial cases of alzheimer-type dementia and 4 sporadic senile cases . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
0,
14
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
17,
28
]
} |
the history was negative for other neurological or otological diseases ( including infectious diseases ) or use of neuro-ototoxic drugs , except for a high incidence of vascular disorders ( hypertension , stroke , and heart infarction ) . | NA | {
"id": "C0042373",
"name": "of vascular disorders",
"pos": [
166,
187
]
} | {
"id": "C0020538",
"name": "hypertension",
"pos": [
190,
202
]
} |
endocardial disease was histologically evident in 18 patients with nonbacterial thrombotic endocarditis , and one patient was found to have nocardia asteroides endocarditis . | NA | {
"id": "C0221390",
"name": "nonbacterial thrombotic endocarditis",
"pos": [
67,
103
]
} | {
"id": "C0014118",
"name": "endocarditis",
"pos": [
160,
172
]
} |
the specificity of this regulation is supported by the evidence that ( 1 ) the degree and topography of the normalization of muscarinic receptor density was entirely dependent on the degree and pattern of cholinergic reinnervation by the fibers of the septal transplant , ( 2 ) cholinergic fiber reinnervation by embryon... | NA | {
"id": "C0034826",
"name": "muscarinic receptor",
"pos": [
125,
144
]
} | {
"id": "C0384752",
"name": "m2 receptors",
"pos": [
381,
393
]
} |
the age-related difference in li 's was found in both groups of patients with astrocytomas but not in those with glioblastomas . | NA | {
"id": "C0004114",
"name": "astrocytomas",
"pos": [
78,
90
]
} | {
"id": "C0017636",
"name": "glioblastomas",
"pos": [
113,
126
]
} |
these two patients with pseudotumor cerebri are unique in their fulminant clinical course and severely increased intracranial pressure . | NA | {
"id": "C0033845",
"name": "pseudotumor cerebri",
"pos": [
24,
43
]
} | {
"id": "C0151740",
"name": "increased intracranial pressure",
"pos": [
103,
134
]
} |
three rate constants ( k1-k3 ) and blood volume ( vb ) were estimated and the regional cerebral metabolic rate for glucose ( rcmrglu ) was subsequently derived using the measured blood glucose value and a regionally invariant value of the lumped constant ( lc ) . | NA | {
"id": "C0017725",
"name": "glucose",
"pos": [
115,
122
]
} | {
"id": "C0005802",
"name": "blood glucose",
"pos": [
179,
192
]
} |
skin tumours showing squamous or hair follicle differentiation are shown to contain the protein antigen , while basal cell carcinomas and tumours with sweat gland differentiation do not . | NA | {
"id": "C0037286",
"name": "skin tumours",
"pos": [
0,
12
]
} | {
"id": "C0038987",
"name": "tumours",
"pos": [
138,
145
]
} |
using an immunohistochemical technique , the development of the cytoskeletal proteins desmin , vimentin , and actin ( using alpha isotype and non-isotype specific antibodies ) was assessed using a semi-quantitative grading system in the pulmonary vascular smooth muscle of nine normal pigs and 19 normal humans at differ... | NA | {
"id": "C0021017",
"name": "isotype",
"pos": [
130,
137
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
163,
173
]
} |
in this paper the phenomenon of a photosensitive ion complex of brilliant yellow and ferric ions formation in the electrolyte phase and its subsequent deposition within a bilayer lipid membrane ( blm ) is described . | NA | {
"id": "C0022023",
"name": "ion",
"pos": [
49,
52
]
} | {
"id": "C0013832",
"name": "electrolyte",
"pos": [
114,
125
]
} |
treatment in vitro of ehrlich ascites tumor cells or human fibroblasts with 8-methoxypsoralen ( 8-mop , 2.4 microm ) and uva irradiation results in a 30 % and 60 % respectively reduction in lysosomal beta-galactosidase activity in situ . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
44,
49
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
59,
70
]
} |
we evaluated the effect of intravenously administered immune globulin ( ivig ) on neonatal group b streptococcal ( gbs ) infection in vivo and in vitro . | NA | {
"id": "C0021027",
"name": "immune globulin",
"pos": [
54,
69
]
} | {
"id": "C0085297",
"name": "ivig",
"pos": [
72,
76
]
} |
to test this hypothesis , we studied 10 infants recovering from severe bronchopulmonary dysplasia ( study weight 2490 +/- 275 gm ; birth weight 1010 +/- 89 gm ; postnatal age 73 +/- 7 days ; postconceptional age 38.5 +/- 1.6 weeks ) and 10 matched control infants ( study weight 2430 +/- 179 gm ; birth weight 2320 +/- 1... | NA | {
"id": "C0005910",
"name": "weight",
"pos": [
106,
112
]
} | {
"id": "C0005612",
"name": "birth weight",
"pos": [
297,
309
]
} |
children with trauma had either duct disruption ( 3 ) , gland fracture ( 4 ) , or pseudocysts formation ( 26 ) . | NA | {
"id": "C0043251",
"name": "trauma",
"pos": [
14,
20
]
} | {
"id": "C0016658",
"name": "fracture",
"pos": [
62,
70
]
} |
f-tgf-beta was incubated with each of the three fibroblast types at 37 degrees c after which time the cells were washed twice and analyzed with a minimum of 10 ( 5 ) cells for each data point . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
48,
58
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
166,
171
]
} |
f-tgf-beta bound rapidly and reversibly to the embryonic , fetal , and adult fibroblasts with saturation being achieved at 1 nmol/l for fetal and adult cells , and 8 nmol/l in the embryonic fibroblasts . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
152,
157
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
190,
201
]
} |
melatonin , epinephrine , and norepinephrine levels were measured during a mock run and in the course of treadmill exercise performed before ( t-1 ) , during ( t-2 ) , and following ( t-3 ) a progressive conditioning ( running ) program . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
12,
23
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
30,
44
]
} |
plasma melatonin , epinephrine , and norepinephrine levels rose significantly ( p less than .01 ) from baseline values for each exercise intensity during all three treadmill runs . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
19,
30
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
37,
51
]
} |
while a dose-response trend was observed in each of the norepinephrine and epinephrine trials , there appeared to be a progressive diminution of this relationship in melatonin between intensities . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
56,
70
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
75,
86
]
} |
further , as training progressed , the peak melatonin concentration was decreased by 52 % from t-1 to t-3 , while peak epinephrine and norepinephrine values diminished only 19 % and 8 % , respectively . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
119,
130
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
135,
149
]
} |
based on this chart review , three themes related to parenting young children emerged : ( 1 ) how psychiatric symptoms affected the mother 's ability to parent her children ; | NA | {
"id": "C0728836",
"name": "young children",
"pos": [
63,
77
]
} | {
"id": "C0008059",
"name": "children",
"pos": [
164,
172
]
} |
throughout the infection , variations were observed in parasite morphology , density , dna content , number of organisms with 2 nuclei and 2 kinetoplasts and infectivity of parasites for mice . | NA | {
"id": "C0009450",
"name": "infection",
"pos": [
15,
24
]
} | {
"id": "C0030499",
"name": "infectivity",
"pos": [
158,
169
]
} |
no variation was found in the other pbmc studied ( cd20+ lymphocytes , cd14+ monocytes and d/dr+ cells ) . | NA | {
"id": "C1321301",
"name": "pbmc",
"pos": [
36,
40
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
97,
102
]
} |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.