text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
except for structurally similar small amino acids , such as alanine , beta-alanine , and serine , compounds acting as glycine-receptor agonists are an unknown class of pharmacological agents . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
38,
49
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
75,
82
]
} |
except for structurally similar small amino acids , such as alanine , beta-alanine , and serine , compounds acting as glycine-receptor agonists are an unknown class of pharmacological agents . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
60,
67
]
} | {
"id": "C0000392",
"name": "beta-alanine",
"pos": [
70,
82
]
} |
three derivatives are also amides , synthesized with 4- ( p-nitroguaiacoxy ) butanoic acid as a photoreactive group either directly or by interposing an amino acid ( glycine or tyrosine ) . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
153,
163
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
166,
173
]
} |
overall , most intact proteins disappeared 24-48 h after blood ingestion by ae . aegypti , and albumin and immunoglobulin g appeared to be the most persistent proteins , irrespective of the source of blood . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
22,
30
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
95,
102
]
} |
direct sprays of 0.5 % trimethacarb wettable powder ( wp ) and chlorpyrifos emulsifiable concentrate ( ec ) and wp provided greater than 70 % kill . | NA | {
"id": "C0991579",
"name": "sprays",
"pos": [
7,
13
]
} | {
"id": "C0032861",
"name": "wp",
"pos": [
112,
114
]
} |
the following sequence of relative anion permeabilities ( in the presence of k+ ) is obtained : f- less than acetate- less than gluconate- less than cl- less than br- less than i- less than no3- less tha scn- . ( vi ) cations as large as tea+ are permeant . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
35,
40
]
} | {
"id": "C0016327",
"name": "f",
"pos": [
96,
97
]
} |
the following sequence of relative anion permeabilities ( in the presence of k+ ) is obtained : f- less than acetate- less than gluconate- less than cl- less than br- less than i- less than no3- less tha scn- . ( vi ) cations as large as tea+ are permeant . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
35,
40
]
} | {
"id": "C0021966",
"name": "i",
"pos": [
221,
222
]
} |
the specific dna-binding protein fis ( factor for inversion stimulation ) , which stimulates site-specific dna inversion by interaction with an enhancer sequence , was purified from an escherichia coli strain overproducing the protein . | NA | {
"id": "C0012940",
"name": "dna-binding protein",
"pos": [
13,
32
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
227,
234
]
} |
1 ) messenger rna genes : the codon strategy is mainly dictated by the base compositional constraints of the corresponding codogenic dna strand . | NA | {
"id": "C0035696",
"name": "messenger rna",
"pos": [
4,
17
]
} | {
"id": "C0009221",
"name": "codon",
"pos": [
30,
35
]
} |
these sequences , termed mu4 and mu5 , have an organization characteristic of transposable elements and possess approximately 200-bp mu terminal inverted repeats that flank internal dna , which is unrelated to other cloned mu elements . | NA | {
"id": "C0012868",
"name": "transposable elements",
"pos": [
78,
99
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
182,
185
]
} |
sequences in coding and noncoding regions of barley stripe mosaic virus ( bsmv ) rnas 1 , 2 , and 3 were compared with those of the monopartite rna genomes of potato virus x ( pvx ) , white clover mosaic virus ( wclmv ) , and tobacco mosaic virus , the bipartite genome of tobacco rattle virus ( trv ) , the quadripartit... | NA | {
"id": "C0887909",
"name": "noncoding",
"pos": [
24,
33
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
397,
400
]
} |
the results suggest that the genomic elements in each bsmv rna are phylogenetically related to those of different plant rna viruses . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
59,
62
]
} | {
"id": "C0242968",
"name": "plant rna",
"pos": [
114,
123
]
} |
linoleic acid caused more pronounced alterations in fatty acid composition of tumor cell lipids than did oleic acid , a feature that parallels the intensity of the cytotoxicity potential of the two free fatty acids . | NA | {
"id": "C0015684",
"name": "fatty acid",
"pos": [
52,
62
]
} | {
"id": "C0015688",
"name": "free fatty acids",
"pos": [
198,
214
]
} |
these results suggest that ( a ) the free carboxyl group of free fatty acids plays a role in killing tumor cells and ( b ) the modification of the fatty acid composition of tumor cells also correlates with the antitumor effects of oleic and linoleic acids . | NA | {
"id": "C0015688",
"name": "free",
"pos": [
37,
41
]
} | {
"id": "C0015684",
"name": "fatty acid",
"pos": [
147,
157
]
} |
a rat brain tumor model ( fischer 344 rats ) with the clinical and pathological features of dissemination via the cerebrospinal fluid ( csf ) pathways was used to demonstrate the efficacy of 5-iodo-2-deoxyuridine ( iudr ) as a radiosensitizer when it is administered directly into the csf . | NA | {
"id": "C0011535",
"name": "deoxyuridine",
"pos": [
200,
212
]
} | {
"id": "C0020811",
"name": "iudr",
"pos": [
215,
219
]
} |
alpha-1 glycoprotein ( alpha 1-gp ) , an acute phase reactant , has been reported to enhance the in vitro neuritic extensions of chick drg cells . | NA | {
"id": "C0029297",
"name": "alpha-1 glycoprotein",
"pos": [
0,
20
]
} | {
"id": "C0001347",
"name": "acute phase reactant",
"pos": [
41,
61
]
} |
six of the 24 patients had acquired immunodeficiency syndrome aids , four had other clinical symptoms of hiv infection , and 14 had no apparent symptoms . | NA | {
"id": "C0001175",
"name": "aids",
"pos": [
62,
66
]
} | {
"id": "C0019693",
"name": "hiv infection",
"pos": [
105,
118
]
} |
neck injuries occurred most frequently in the setting of mva 's ( 85 % ) and multisystem trauma ( 70 % ) and tended to involve two main levels of the cervical spine : c2 ( 31 % ) and the two lower cervical vertebrae c6 and c7 ( 50 % ) . | NA | {
"id": "C0027531",
"name": "neck injuries",
"pos": [
0,
13
]
} | {
"id": "C0043251",
"name": "trauma",
"pos": [
89,
95
]
} |
verification of abstinence from cannabinoid use after initial identification requires documentation of falling quantitative levels of urinary 11-nor-delta-9-tetrahydrocannabinol-9-carboxylic acid ( thc-cooh ) over an extended time period . | NA | {
"id": "C0006864",
"name": "cannabinoid",
"pos": [
32,
43
]
} | {
"id": "C0039663",
"name": "thc",
"pos": [
198,
201
]
} |
osteoradionecrosis ( orn ) is a complex metabolic and tissue homeostatic deficiency created by radiation-induced tissue injury . | NA | {
"id": "C0029461",
"name": "osteoradionecrosis",
"pos": [
0,
18
]
} | {
"id": "C0034530",
"name": "radiation",
"pos": [
95,
104
]
} |
5 ) the normal bladder contains greater amount of creatine phosphate and lesser amounts of creatine than the normal ileum . | NA | {
"id": "C0031634",
"name": "creatine",
"pos": [
50,
58
]
} | {
"id": "C0010286",
"name": "creatine",
"pos": [
91,
99
]
} |
the development and reversal of tolerance to the hemodynamic and anti-anginal effects of isosorbide dinitrate in a sustained release form ( isdn-sr ) were investigated in 11 male patients ( mean age 58.9 y.o . ) with stable effort angina . | NA | {
"id": "C0002962",
"name": "anginal",
"pos": [
70,
77
]
} | {
"id": "C0340288",
"name": "stable",
"pos": [
217,
223
]
} |
and we used this method in patient with liver diseases ( acute hepatitis : 5 , chronic hepatitis : 7 , liver cirrhosis : 25 cases ) . | NA | {
"id": "C0023895",
"name": "liver diseases",
"pos": [
40,
54
]
} | {
"id": "C0023890",
"name": "liver",
"pos": [
103,
108
]
} |
8 of 14 patients with inferior mi had right ventricular mi , that might have affected evaluation of mi size and resulted in no correlation between variables . | NA | {
"id": "C0340305",
"name": "inferior mi",
"pos": [
22,
33
]
} | {
"id": "C0027051",
"name": "mi",
"pos": [
100,
102
]
} |
it was suggested that 99mtcpyp-spect was a useful method to evaluate mi size and to predict prognosis of cardiac function in patients with anterior mi but not in patients with inferior mi . | NA | {
"id": "C0027051",
"name": "mi",
"pos": [
69,
71
]
} | {
"id": "C0340293",
"name": "anterior mi",
"pos": [
139,
150
]
} |
it was suggested that 99mtcpyp-spect was a useful method to evaluate mi size and to predict prognosis of cardiac function in patients with anterior mi but not in patients with inferior mi . | NA | {
"id": "C0027051",
"name": "mi",
"pos": [
69,
71
]
} | {
"id": "C0340305",
"name": "inferior mi",
"pos": [
176,
187
]
} |
[ prognosis of the course of ischemic heart disease in patients with a history of macrofocal and transmural myocardial infarction in relation to the degree of blood pressure in the pulmonary artery ] . | NA | {
"id": "C0151744",
"name": "of the",
"pos": [
12,
18
]
} | {
"id": "C0027051",
"name": "myocardial infarction",
"pos": [
108,
129
]
} |
by contrast , none of the essential aa were low in muscle , and methionine was increased as were ornithine , asparagine , and aspartic acid ; | NA | {
"id": "C0002525",
"name": "essential aa",
"pos": [
26,
38
]
} | {
"id": "C0025646",
"name": "methionine",
"pos": [
64,
74
]
} |
adenosine-5'-ethylcarboxamide ( neca ) , an a2 agonist , did not induce significant changes in pcsa whereas n6-s-1-methyl-2-phenylethyl adenosine ( s-pia ) , an a1 agonist , induced a dose-dependent decrease in pcsa . | NA | {
"id": "C0050789",
"name": "neca",
"pos": [
32,
36
]
} | {
"id": "C0001443",
"name": "adenosine",
"pos": [
136,
145
]
} |
in contrast to nk cells , the growth and propagation of adpkd cells were not supported by defined medium alone but required serum supplementation and adpkd cells did not respond to growth factors ( insulin , transferrin , egf ) that promoted the growth of nk cells . | NA | {
"id": "C0022680",
"name": "of adpkd",
"pos": [
53,
61
]
} | {
"id": "C0085413",
"name": "adpkd",
"pos": [
150,
155
]
} |
we used an in vitro model , mdck cyst , to determine the extent to which pharmacologic compounds known to inhibit plasma membrane solute transport mechanisms could alter the enlargement of renal epithelial cysts . | NA | {
"id": "C0010709",
"name": "cyst",
"pos": [
33,
37
]
} | {
"id": "C0014511",
"name": "epithelial cysts",
"pos": [
195,
211
]
} |
[ difficulties in the diagnosis and treatment of injuries of the abdominal organs in a child with combined trauma ] . | NA | {
"id": "C0848377",
"name": "injuries",
"pos": [
49,
57
]
} | {
"id": "C0043251",
"name": "trauma",
"pos": [
107,
113
]
} |
the cell lines of a medulloblastoma ( d283 med ) , a retinoblastoma ( weri-rb1 ) , and an astrocytic glioma ( u-251 mg ) were cultured in an organ culture system , pulse-fed with bromodeoxyuridine , and double-labeled by immunoperoxidase and by the avidin-biotin peroxidase complex method for bromodeoxyuridine and for i... | NA | {
"id": "C0021769",
"name": "intermediate filament proteins",
"pos": [
319,
349
]
} | {
"id": "C0042666",
"name": "vimentin",
"pos": [
404,
412
]
} |
the cell lines of a medulloblastoma ( d283 med ) , a retinoblastoma ( weri-rb1 ) , and an astrocytic glioma ( u-251 mg ) were cultured in an organ culture system , pulse-fed with bromodeoxyuridine , and double-labeled by immunoperoxidase and by the avidin-biotin peroxidase complex method for bromodeoxyuridine and for i... | NA | {
"id": "C0021769",
"name": "intermediate filament proteins",
"pos": [
319,
349
]
} | {
"id": "C0017626",
"name": "glial fibrillary acidic",
"pos": [
417,
440
]
} |
the cardiac arrhythmias were : right bundle branch block 36 , premature atrial and ventricular contractions 15 , supraventricular tachycardia ( svt ) 15 , atrioventricular ( av ) block 7 , sinus bradycardia 3 , atrial fibrillation 2 , ventricular tachycardia and fibrillation 2 , wolff-parkinson-white syndrome without s... | NA | {
"id": "C0003811",
"name": "cardiac arrhythmias",
"pos": [
4,
23
]
} | {
"id": "C0004238",
"name": "atrial fibrillation",
"pos": [
211,
230
]
} |
the cardiac arrhythmias were : right bundle branch block 36 , premature atrial and ventricular contractions 15 , supraventricular tachycardia ( svt ) 15 , atrioventricular ( av ) block 7 , sinus bradycardia 3 , atrial fibrillation 2 , ventricular tachycardia and fibrillation 2 , wolff-parkinson-white syndrome without s... | NA | {
"id": "C0039240",
"name": "supraventricular tachycardia",
"pos": [
113,
141
]
} | {
"id": "C0039231",
"name": "svt",
"pos": [
319,
322
]
} |
the cardiac arrhythmias were : right bundle branch block 36 , premature atrial and ventricular contractions 15 , supraventricular tachycardia ( svt ) 15 , atrioventricular ( av ) block 7 , sinus bradycardia 3 , atrial fibrillation 2 , ventricular tachycardia and fibrillation 2 , wolff-parkinson-white syndrome without s... | NA | {
"id": "C0042514",
"name": "ventricular tachycardia",
"pos": [
118,
141
]
} | {
"id": "C0039231",
"name": "svt",
"pos": [
319,
322
]
} |
ubiquinone ( co q10 ) is a natural substance suitable for therapeutic use in cardiology and in the treatment of some muscular diseases . | NA | {
"id": "C0041536",
"name": "ubiquinone",
"pos": [
0,
10
]
} | {
"id": "C0056077",
"name": "co q10",
"pos": [
13,
19
]
} |
exercise exhibited no independent effect on cholesterol or hdl-c concentrations , although there was a trend in a favorable direction . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
44,
55
]
} | {
"id": "C0023822",
"name": "hdl-c",
"pos": [
59,
64
]
} |
effect of the benzodiazepines diazepam , des-n-methyldiazepam and midazolam on corticosteroid biosynthesis in bovine adrenocortical cells in vitro ; | NA | {
"id": "C0005064",
"name": "benzodiazepines",
"pos": [
14,
29
]
} | {
"id": "C0026056",
"name": "midazolam",
"pos": [
66,
75
]
} |
daily oral administration of flavodilol to shr for 4 days resulted in augmented vasopressor responses to exogenously administered epinephrine ( epi ) or norepinephrine ( ne ) and attenuated responses to exogenously administered tyramine . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
130,
141
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
153,
167
]
} |
apamin , a bee venom polypeptide , is reported to block the ca2+-dependent k+ channel in smooth muscle , hepatocyte , and neuroblastoma cells . | NA | {
"id": "C0003521",
"name": "apamin",
"pos": [
0,
6
]
} | {
"id": "C0004920",
"name": "bee venom",
"pos": [
11,
20
]
} |
thus , nisoldipine administered intrarenally to anesthetized dogs exerts a diuretic action by way of tubular effects , as is the case with other dihydropyridine calcium channel blockers . | NA | {
"id": "C0028116",
"name": "nisoldipine",
"pos": [
7,
18
]
} | {
"id": "C2945601",
"name": "dihydropyridine calcium channel blockers",
"pos": [
145,
185
]
} |
only a small contribution toward adenosine triphosphate maintenance comes from creatine phosphate , since creatine phosphate , inorganic phosphate , and total creatine levels in the appendage are low ( less than 2 mumol.gm-1 tissue wet weight ) . | NA | {
"id": "C0031634",
"name": "creatine phosphate",
"pos": [
79,
97
]
} | {
"id": "C0010286",
"name": "creatine",
"pos": [
159,
167
]
} |
usually , a patient with isolated crohn 's disease of the stomach will have the clinical symptoms of nausea , vomiting , and epigastric pain and radiographic evidence of a small contracted stomach ( or , occasionally , a huge dilated stomach ) . | NA | {
"id": "C0038354",
"name": "disease of the",
"pos": [
43,
57
]
} | {
"id": "C0038353",
"name": "dilated stomach",
"pos": [
226,
241
]
} |
the reasons why we think that hd in patients with hiv infections should be considered as indicating acquired immunodeficiency syndrome are discussed . | NA | {
"id": "C0019693",
"name": "hiv infections",
"pos": [
50,
64
]
} | {
"id": "C0001175",
"name": "acquired",
"pos": [
100,
108
]
} |
however , we must now also consider the possibility that these patients will occasionally develop other types of autoimmune disorders such as rheumatoid arthritis and sjogren 's syndrome and , on occasion , have their skin disease triggered by drugs such as hydrochlorothiazide . | NA | {
"id": "C0003873",
"name": "rheumatoid arthritis",
"pos": [
142,
162
]
} | {
"id": "C1527336",
"name": "sjogren 's syndrome",
"pos": [
167,
186
]
} |
because the clinical and histologic findings of le panniculitis overlap with those of other connective tissue diseases , evaluation of patients suspected of having le panniculitis should include a complete history and physical examination as well as serologic studies , determination of peripheral blood counts , and tes... | NA | {
"id": "C0009782",
"name": "of",
"pos": [
45,
47
]
} | {
"id": "C0030326",
"name": "panniculitis",
"pos": [
167,
179
]
} |
[ in vitro culture of melanocyte-bearing epidermis and its application in the treatment of vitiligo and the stable leukodermas ] . | NA | {
"id": "C0042900",
"name": "vitiligo",
"pos": [
91,
99
]
} | {
"id": "C0162835",
"name": "leukodermas",
"pos": [
115,
126
]
} |
in both newborn and twenty day old rats , bacterial ( s. enteritidis ) endotoxin caused a marked decrease in adrenal epinephrine and norepinephrine . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
117,
128
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
133,
147
]
} |
in contrast , noradrenaline , adrenaline , acetylcholine , gamma-aminobutyric acid and histamine ( 10 microm ) had no effect on dopamine uptake by platelets . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
14,
27
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
30,
40
]
} |
this study was undertaken to determine whether the effect of feeding alpha-linolenic acid ( 18:3 omega 3 ) or epa plus docosahexaenoic acid ( 22:6 omega 3 ) on intestinal absorption of nutrients was influenced by the major source of dietary lipid , hydrogenated beef tallow or safflower oil . | NA | {
"id": "C0015689",
"name": "omega 3",
"pos": [
97,
104
]
} | {
"id": "C0012968",
"name": "docosahexaenoic acid",
"pos": [
119,
139
]
} |
when eicosapentaenoic acid/docosahexaenoic acid was given with beef tallow ( but not with safflower oil ) , there was lower uptake of 18:0 , 20:5 omega 3 and cholesterol . | NA | {
"id": "C0012968",
"name": "docosahexaenoic acid",
"pos": [
27,
47
]
} | {
"id": "C0015689",
"name": "omega 3",
"pos": [
146,
153
]
} |
male sprague-dawley rats at the ages of four weeks and nine months were fed purified diets containing 20 % proteins either as casein ( cas ) , milk whey protein ( why ) , or soybean protein ( soy ) with 5 % sardine oil for four weeks . | NA | {
"id": "C0007332",
"name": "casein",
"pos": [
126,
132
]
} | {
"id": "C0026138",
"name": "milk",
"pos": [
143,
147
]
} |
in contrast , the 1,4-dihydropyridine ( dhp ) antagonist nifedipine , at concentrations up to 100 microm , did not affect the response of hypothalamic alpha-msh neurons to depolarizing concentrations of kcl . | NA | {
"id": "C0012315",
"name": "dihydropyridine",
"pos": [
22,
37
]
} | {
"id": "C0028066",
"name": "nifedipine",
"pos": [
57,
67
]
} |
in addition , the secretion of alpha-msh induced by high k+ concentrations was not reduced by nifedipine ( 10 microm ) in the presence of diltiazem ( 1 microm ) , a benzothiazepine derivative which increases the affinity of the dhp antagonist for l-type voc channels . | NA | {
"id": "C0028066",
"name": "nifedipine",
"pos": [
94,
104
]
} | {
"id": "C0012315",
"name": "dhp",
"pos": [
228,
231
]
} |
the deduced primary sequence of rat brain 5b4/ncam-ld predicts a large cytoplasmic domain ( 390 amino acids , mr 39,284 ) of striking amino acid composition ( 52 % proline , alanine , serine and threonine ) and little predicted alpha or beta secondary structure : its function is unknown . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
96,
106
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
174,
181
]
} |
although the average ratio for urine alcohol concentration to blood alcohol concentration lay close to the ratio of 4:3 quoted in the literature , the actual ratios determined were widely scattered around this value . | NA | {
"id": "C0001962",
"name": "alcohol",
"pos": [
37,
44
]
} | {
"id": "C0684262",
"name": "blood alcohol concentration",
"pos": [
62,
89
]
} |
this report concerns the observations of gross motor movement of the lower right limb of a corpse two hours after apparent death . | NA | {
"id": "C0006629",
"name": "corpse",
"pos": [
91,
97
]
} | {
"id": "C0011065",
"name": "death",
"pos": [
123,
128
]
} |
adsorption of antisera with intact or sonicated smooth or rough salmonellae prior to immunoblotting showed that antibodies were directed against exposed , masked and intracellular antigens . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
14,
22
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
112,
122
]
} |
presence of anti-dna antibody in diabetes mellitus : its relation to the duration of diabetes and diabetic complications . | NA | {
"id": "C0011849",
"name": "diabetes mellitus",
"pos": [
33,
50
]
} | {
"id": "C0342257",
"name": "diabetic complications",
"pos": [
98,
120
]
} |
these data were based on southern blot analysis , using the sm resistance gene ( encoding aminoglycoside phosphoryl transferase ) as probe cut out from pbp1 plasmid . | NA | {
"id": "C0038425",
"name": "sm",
"pos": [
60,
62
]
} | {
"id": "C0002556",
"name": "aminoglycoside",
"pos": [
90,
104
]
} |
in micro elisa of this study as well as all protocols of the previous who/iuis collaborative study , antigens ( myeloma igg subclasses ) were immobilized or fixed to a solid phase , resulting in possible variations in their epitope expressions . | NA | {
"id": "C0003320",
"name": "antigens",
"pos": [
101,
109
]
} | {
"id": "C0003316",
"name": "epitope",
"pos": [
224,
231
]
} |
while the prevalence of asthma was not high compared with other occupational asthmas , it was noteworthy . | NA | {
"id": "C0004096",
"name": "asthma",
"pos": [
24,
30
]
} | {
"id": "C0264423",
"name": "occupational asthmas",
"pos": [
64,
84
]
} |
it is therefore concluded that children with rri do not , as has often been suggested , present any basic disorder in salivary iga , but that the response of secretory iga is far more sensitive to infection than the system as a whole . | NA | {
"id": "C0035243",
"name": "rri",
"pos": [
45,
48
]
} | {
"id": "C0009450",
"name": "infection",
"pos": [
197,
206
]
} |
group ii included 15 subjects ( 6 with spe , 5 with ige , 3 with symptomatic ge and 1 with undetermined epilepsy ) in whom one or several seizures had been recorded . | NA | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
104,
112
]
} | {
"id": "C0036572",
"name": "seizures",
"pos": [
138,
146
]
} |
a/eeg was performed in order to : 1 ) obtain better clinical and eeg characterization of seizures , 2 ) study the circadian distribution of seizures , 3 ) verify the efficacy of drug treatment and , 4 ) establish the epileptic or non-epileptic nature of some ictal events . | NA | {
"id": "C0036572",
"name": "seizures",
"pos": [
89,
97
]
} | {
"id": "C0014544",
"name": "epileptic",
"pos": [
234,
243
]
} |
hypocalcemia ( hypoca ) and hypomagnesemia ( hypomg ) produce cns and pns irritability with seizures and tetany , respectively , being the major clinical manifestations . | NA | {
"id": "C0020598",
"name": "hypocalcemia",
"pos": [
0,
12
]
} | {
"id": "C0039621",
"name": "tetany",
"pos": [
105,
111
]
} |
paraneoplastic syndromes are heterogeneous in their clinical presentations and their associations with particular tumor types and are an important part of the differential diagnosis of neurologic dysfunction in patients with or without a known neoplasm . | NA | {
"id": "C0030472",
"name": "paraneoplastic syndromes",
"pos": [
0,
24
]
} | {
"id": "C0027651",
"name": "neoplasm",
"pos": [
244,
252
]
} |
specific autoantibodies in other syndromes appear to be valuable diagnostic markers for the presence of an underlying malignancy , but the actual role of these antibodies in producing tissue damage and clinical disease is still unknown . | NA | {
"id": "C0039082",
"name": "syndromes",
"pos": [
33,
42
]
} | {
"id": "C0012634",
"name": "disease",
"pos": [
211,
218
]
} |
neurologic symptoms and signs are common in most of the vasculitic syndromes and may be the presenting ( or only ) manifestation of the disease . | NA | {
"id": "C0039082",
"name": "syndromes",
"pos": [
67,
76
]
} | {
"id": "C0012634",
"name": "disease",
"pos": [
136,
143
]
} |
[ a study of adequate energy , amino acid , and carbohydrate requirements in postoperative total parenteral nutrition -- the effect of branched chain amino acid ( bcaa ) and carbohydrate mixture of glucose , fructose , and xylitol ( gfx ) ] . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
31,
41
]
} | {
"id": "C0002521",
"name": "branched chain amino",
"pos": [
135,
155
]
} |
the effects of aa formula , rich in bcaa ( 30 % bcaa ) , as a nitrogen source and the carbohydrate mixture of glucose , fructose , and xylitol ( gfx = 4:2:1 ) , on nitrogen sparing were also studied . | NA | {
"id": "C0002520",
"name": "aa",
"pos": [
15,
17
]
} | {
"id": "C0002521",
"name": "bcaa",
"pos": [
48,
52
]
} |
the regimens were as follows : g1 : 40kcal/kg , standard amino acid ( 21 % bcaa ) 1.5g/kg . day , g2 : 40kcal/kg , 30 % bcaa 1.5g/kg.day , g3 : 30kcal/kg , 21 % bcaa 1.5g/kg.day , g4 : 30kcal/kg , 30 % bcaa 1.5g/kg.day , g5 : 40kcal/kg , 21 % bcaa 1.5g/kg.day . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
57,
67
]
} | {
"id": "C0002521",
"name": "bcaa",
"pos": [
243,
247
]
} |
these results indicate that bcaa rich amino acid formula will induce a more favorable nitrogen sparing effect than a conventional aa formula on tpn patients under surgical stress . | NA | {
"id": "C0002521",
"name": "bcaa",
"pos": [
28,
32
]
} | {
"id": "C0002520",
"name": "aa",
"pos": [
130,
132
]
} |
we studied protective effects of dibutyryl cyclic amp ( dbcamp ) which is a permeable form of cyclic amp ( camp ) , the intracellular second messenger , on d-galactosamine ( d-gal , 1.5g/kg i.p . ) induced acute liver failure . | NA | {
"id": "C0012054",
"name": "dibutyryl cyclic amp",
"pos": [
33,
53
]
} | {
"id": "C0001455",
"name": "cyclic amp",
"pos": [
94,
104
]
} |
they did not affect the utilization of vitamin b12 or other cobalamins for methionine biosynthesis , even in strains with decreased outer membrane transport of vitamin b12 . | NA | {
"id": "C0042845",
"name": "vitamin b12",
"pos": [
39,
50
]
} | {
"id": "C0086024",
"name": "cobalamins",
"pos": [
60,
70
]
} |
when cells at 30 degrees c were labeled with [ 3h ] -thymidine and then shifted to 46 degrees or 49 degrees c for 20 min , the profiles of sedimentation of their cellular dna in an alkaline sucrose gradient revealed a decrease in the size of dna to a quarter of that at 30 degrees c in the mutant , but not in wild-type ... | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
171,
174
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
293,
294
]
} |
proteolytic degradation of ifn alpha by extracellular proteases was avoided by a combination of constitutive expression and secretion during the logarithmic growth phase and the use of exoprotease-reduced host strains . | NA | {
"id": "C0030940",
"name": "proteases",
"pos": [
54,
63
]
} | {
"id": "C0117059",
"name": "exoprotease",
"pos": [
185,
196
]
} |
structurally similar amino acids mimicked the action of glycine , with d-isomers being more potent than l-isomers . | NA | {
"id": "C0002520",
"name": "amino",
"pos": [
21,
26
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
56,
63
]
} |
glycine stimulation of tcp binding required the presence of nmda agonists and was inhibited by the nmda antagonist d-2-amino-5-phosphonovaleric acid . | NA | {
"id": "C0017890",
"name": "glycine",
"pos": [
0,
7
]
} | {
"id": "C0002520",
"name": "amino",
"pos": [
119,
124
]
} |
madin-darby canine kidney cells ( mdck ) are known to release free arachidonic acid and arachidonic acid metabolites ( aa ) in response to tumor-promoting phorbol esters , such as tetradecanoyl phorbol-13-acetate , and to agonists active at alpha 1-adrenergic and bradykinin b2 receptors . | NA | {
"id": "C0031586",
"name": "phorbol esters",
"pos": [
155,
169
]
} | {
"id": "C0039654",
"name": "tetradecanoyl phorbol",
"pos": [
180,
201
]
} |
in conclusion caseins , the main milk proteins , should not only be considered as a nutriment but as a possible source of biologically active components . | NA | {
"id": "C0007332",
"name": "caseins",
"pos": [
14,
21
]
} | {
"id": "C0026138",
"name": "milk proteins",
"pos": [
33,
46
]
} |
localization and relative frequency of single-strand cleavages within these sequences were observed to change in the presence of the cytotoxic alkaloid camptothecin . | NA | {
"id": "C0002062",
"name": "alkaloid",
"pos": [
143,
151
]
} | {
"id": "C0006812",
"name": "camptothecin",
"pos": [
152,
164
]
} |
a monoclonal antigen-binding t cell immunoprotein : antigenic relatedness to t cell receptor beta chain fr1 v and j peptide segments : physicochemical distinctiveness from classical immunoglobulins and t cell receptor heterodimers . | NA | {
"id": "C0021072",
"name": "immunoprotein",
"pos": [
36,
49
]
} | {
"id": "C0021027",
"name": "immunoglobulins",
"pos": [
182,
197
]
} |
these studies raise the possibility that antigen-binding soluble t cell molecules might belong to a new family of immunoproteins , that is related to , but distinct from , classical immunoglobulins and alpha beta or gamma delta heterodimers . | NA | {
"id": "C0021072",
"name": "immunoproteins",
"pos": [
114,
128
]
} | {
"id": "C0021027",
"name": "immunoglobulins",
"pos": [
182,
197
]
} |
common antigenic and allergenic determinants on codfish proteins detected with mouse monoclonal igg and human ige antibodies . | NA | {
"id": "C0003320",
"name": "antigenic",
"pos": [
7,
16
]
} | {
"id": "C0002092",
"name": "allergenic",
"pos": [
21,
31
]
} |
using monoclonal antibodies and sera from human cod-allergic subjects as immunological probes , common antigenic and allergenic determinants were demonstrated on some codfish proteins . | NA | {
"id": "C0003320",
"name": "antigenic",
"pos": [
103,
112
]
} | {
"id": "C0002092",
"name": "allergenic",
"pos": [
117,
127
]
} |
these studies promote speculation regarding the relative immunogenicity of antigenic and allergenic determinants and the size and diversity of the ige repertoire , given the potential immunogenicity of the entire protein surface . | NA | {
"id": "C0003320",
"name": "antigenic",
"pos": [
75,
84
]
} | {
"id": "C0002092",
"name": "allergenic",
"pos": [
89,
99
]
} |
we previously showed the importance of the 3-deoxy-d-manno-2-octulosonic acid ( kdo ) residue in endotoxins ( lipopolysaccharides , lps ) for the induction of the synthesis and release of interleukin-1 ( il-1 ) by human monocytes . | NA | {
"id": "C0014264",
"name": "endotoxins",
"pos": [
97,
107
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
132,
135
]
} |
these data confirm that the kdo residue ( s ) present in all endotoxins play ( s ) a major role in the signal ( s ) leading to il-1 production by human monocytes , and show that il-1 induction by lps ( 1 ) requires a free carboxyl group in the kdo and ( 2 ) is correlated with the degree of substitution of the kdo . | NA | {
"id": "C0014264",
"name": "endotoxins",
"pos": [
61,
71
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
196,
199
]
} |
the concentration of the anti-oxidant enzymes catalase ( cat ) , peroxidases ( pod ) and superoxide dismutases ( sod ) in different blood fractions , and the chromosomal sensitivity of lymphocytes to bleomycin-induced free radicals ( expressed as frequency of dicentrics per bleomycin dose ) were analyzed in 10 normal h... | NA | {
"id": "C0007367",
"name": "catalase",
"pos": [
46,
54
]
} | {
"id": "C0031179",
"name": "peroxidases",
"pos": [
65,
76
]
} |
on the other hand , no correlation between the yield of bleomycin-induced dicentrics and the concentration of cat or pod was detected in any of the blood fractions analyzed . | NA | {
"id": "C0007367",
"name": "cat",
"pos": [
110,
113
]
} | {
"id": "C0031179",
"name": "pod",
"pos": [
117,
120
]
} |
in the present study , we show that chinese hamster fibroblasts ( v79 cells ) also produce cf when exposed to tpa . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
52,
63
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
70,
75
]
} |
a more prolonged delay in g2 phase after irradiation was seen in different a-t cell types that included lymphoblastoid cells , fibroblasts and sv40-transformed fibroblasts . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
119,
124
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
160,
171
]
} |
since the transient transfection assay only depends on the uptake and transcriptional activity of foreign dna , and does not necessitate dna integration , this suggests that the xrs strains do not have a defect in the uptake of foreign dna , but might have a defect in integration or the processing of dna molecules prio... | NA | {
"id": "C0000702",
"name": "a",
"pos": [
12,
13
]
} | {
"id": "C0012854",
"name": "dna molecules",
"pos": [
302,
315
]
} |
characteristic morphological changes of the fibroblasts and specific shifts in the [ 35s ] methionine polypeptide pattern of total cellular proteins support the notion that mmc accelerates the differentiation pathway from mitotic ( mf ) to post-mitotic fibroblasts ( pmf ) . | NA | {
"id": "C0007634",
"name": "cellular",
"pos": [
131,
139
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
253,
264
]
} |
normal human fibroblasts and chinese hamster cells or cell-free extracts from these cell lines were treated with azide and the sonicates tested for mutagenicity in salmonella strain ta1530 . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
13,
24
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
45,
50
]
} |
the microsomal fraction of normal human skeletal muscle was subfractionated by isopycnic sucrose-density centrifugation , using the procedure originally described by saito et al . for rabbit fast muscle , and specific markers of the junctional face membrane of terminal cisternae ( tc ) ( ryanodine receptor , high-molec... | NA | {
"id": "C0006732",
"name": "calcium-binding",
"pos": [
370,
385
]
} | {
"id": "C0006787",
"name": "calsequestrin",
"pos": [
394,
407
]
} |
little or no change was seen in serum lipid or lipoprotein levels during treatment with captopril , whereas hydrochlorothiazide caused significant increases in serum total ( 5 percent ) and low-density lipoprotein ( 6 percent ) cholesterol levels and total ( 15 percent ) and very-low-density lipoprotein ( 25 percent ) ... | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
47,
58
]
} | {
"id": "C0023825",
"name": "very-low-density",
"pos": [
276,
292
]
} |
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