text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
the single-headed myosins called myosin-i were first isolated from the protozoan acanthamoeba and subsequently identified in other cells . | NA | {
"id": "C0027096",
"name": "myosins",
"pos": [
18,
25
]
} | {
"id": "C0086669",
"name": "myosin-i",
"pos": [
33,
41
]
} |
these two proteins , together with the yeast gcn4 protein , belong to a growing family of transcription factors , including fosb , fra1 , junb and jund , whose members share a highly conserved dna-binding domain . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
10,
18
]
} | {
"id": "C0040648",
"name": "transcription factors",
"pos": [
90,
111
]
} |
recent work implicates the membrane glycoprotein cd36 ( platelet glycoprotein iv ; refs 2-5 ) and the multi-functional glycoprotein thrombospondin as receptors . | NA | {
"id": "C0025248",
"name": "membrane",
"pos": [
27,
35
]
} | {
"id": "C0017968",
"name": "glycoprotein",
"pos": [
119,
131
]
} |
human complement protein c9 is a hydrophilic serum glycoprotein responsible for efficient expression of the cytotoxic and cytolytic functions of complement . | NA | {
"id": "C0009526",
"name": "complement protein c9",
"pos": [
6,
27
]
} | {
"id": "C0009498",
"name": "complement",
"pos": [
145,
155
]
} |
the other glomerulopathies may be mediated by immune complexes , containing tumour-derived antigens and their antibodies , either formed in situ or deposited as complexes from the circulation . | NA | {
"id": "C0003313",
"name": "immune complexes",
"pos": [
46,
62
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
110,
120
]
} |
these results demonstrate that hypothalamic npy plays a role in mediating the estradiol/progesterone-induced gonadotropin surge and suggests that this neuropeptide plays a physiological role in normal ovulatory surges of lh and fsh . | NA | {
"id": "C0027893",
"name": "npy",
"pos": [
44,
47
]
} | {
"id": "C0027895",
"name": "neuropeptide",
"pos": [
151,
163
]
} |
our substitution of biocompatible titanium wire ( titanium 6 a1-4v eli alloy , specialty steel and forge , leonia , new jersey ) for stainless steel wire produced identical immediate stabilization and ultimate bony fusion of the fracture and yielded minimal mri artifacts overlying the immediately adjacent spinal cord a... | NA | {
"id": "C0002154",
"name": "alloy",
"pos": [
71,
76
]
} | {
"id": "C0038239",
"name": "steel",
"pos": [
143,
148
]
} |
our substitution of biocompatible titanium wire ( titanium 6 a1-4v eli alloy , specialty steel and forge , leonia , new jersey ) for stainless steel wire produced identical immediate stabilization and ultimate bony fusion of the fracture and yielded minimal mri artifacts overlying the immediately adjacent spinal cord a... | NA | {
"id": "C0038239",
"name": "steel",
"pos": [
89,
94
]
} | {
"id": "C0038126",
"name": "stainless steel",
"pos": [
133,
148
]
} |
on computed tomographic scan they typically appear as large , hyperdense , unenhanced masses , with large cysts and must be differentiated from tumors more common in infants , such as teratomas , ependymomas , and mixed tumors . | NA | {
"id": "C0010709",
"name": "cysts",
"pos": [
106,
111
]
} | {
"id": "C0027651",
"name": "tumors",
"pos": [
220,
226
]
} |
morphological analysis using nissl-staining , antibodies to glial acidic fibrillary protein to evaluate the degree of gliosis and antiserum to neurofilament as a neuronal marker did not reveal any marked differences between nerve growth factor- and cytochrome c-treated grafts . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
46,
56
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
130,
139
]
} |
the correlation between densities of d1 and d2 receptors provides an anatomical framework for evaluating behavioral and electrophysiological evidence of an interaction between the two dopamine receptor subtypes . | NA | {
"id": "C0058698",
"name": "d2 receptors",
"pos": [
44,
56
]
} | {
"id": "C0034798",
"name": "dopamine receptor",
"pos": [
184,
201
]
} |
in order to study the role of protein kinase c in the regulation of tyrosine hydroxylase phosphorylation in pc12 cells , the effects of various agonists on diacylglycerol accumulation in pc12 cells were measured and the ability of these agonists to increase the phosphorylation tyrosine hydroxylase in protein kinase c-d... | NA | {
"id": "C0041491",
"name": "tyrosine",
"pos": [
68,
76
]
} | {
"id": "C0020364",
"name": "hydroxylase",
"pos": [
287,
298
]
} |
bradykinin or 55 mm k+ increased the incorporation of 32p into four tyrosine hydroxylase phosphopeptides , including peptide t3 . | NA | {
"id": "C0031684",
"name": "phosphopeptides",
"pos": [
89,
104
]
} | {
"id": "C0030956",
"name": "peptide",
"pos": [
117,
124
]
} |
prolonged exposure of cells to either n6-r-phenylisopropyladenosine or 5'-n-ethylcarboxamidoadenosine was associated with a small but significant degree of morphological differentiation , comparable to that induced by dibutyryl camp , and therefore presumably related to the prolonged increase of intracellular camp leve... | NA | {
"id": "C0031484",
"name": "phenylisopropyladenosine",
"pos": [
43,
67
]
} | {
"id": "C0001443",
"name": "adenosine",
"pos": [
343,
352
]
} |
prolonged exposure of cells to either n6-r-phenylisopropyladenosine or 5'-n-ethylcarboxamidoadenosine was associated with a small but significant degree of morphological differentiation , comparable to that induced by dibutyryl camp , and therefore presumably related to the prolonged increase of intracellular camp leve... | NA | {
"id": "C0050789",
"name": "5",
"pos": [
71,
72
]
} | {
"id": "C0001443",
"name": "adenosine",
"pos": [
343,
352
]
} |
this allows classification of the acetylcholine receptors of n1e-115 cells as neuronal type nicotinic receptors . | NA | {
"id": "C0034792",
"name": "acetylcholine receptors",
"pos": [
34,
57
]
} | {
"id": "C0034830",
"name": "nicotinic receptors",
"pos": [
92,
111
]
} |
we found no differences in stroke severity using our measures but blacks had a statistically higher proportion of lacunar stroke , while whites had a higher proportion of embolic stroke . | NA | {
"id": "C0038454",
"name": "stroke",
"pos": [
27,
33
]
} | {
"id": "C3178801",
"name": "lacunar stroke",
"pos": [
114,
128
]
} |
during may through october 1987 , 17 children between the ages of 3 and 18 years with brain tumors underwent mri examinations , before and after gd-dtpa ( 11 gliomas , 4 medulloblastomas , 1 craniopharyngioma , and 1 child with neurofibromatosis and no pathologic diagnosis ) . | NA | {
"id": "C0017638",
"name": "gliomas",
"pos": [
158,
165
]
} | {
"id": "C0025149",
"name": "medulloblastomas",
"pos": [
170,
186
]
} |
in the 7 new patients , gd-dtpa defined tumor margins in all , and demonstrated internal tumor architecture ( vessels , necrosis , and cysts ) in 5 . | NA | {
"id": "C0027651",
"name": "tumor",
"pos": [
40,
45
]
} | {
"id": "C0010709",
"name": "cysts",
"pos": [
135,
140
]
} |
histologically , 4 lymphomas were large cell , 3 were mixed large and small cell , and 1 could not be classified by the working formulation for non-hodgkin 's lymphomas . | NA | {
"id": "C0024299",
"name": "lymphomas",
"pos": [
19,
28
]
} | {
"id": "C0024305",
"name": "non-hodgkin 's lymphomas",
"pos": [
144,
168
]
} |
to investigate systemic serotonin ( 5-ht ) metabolism in migraine , we determined platelet and platelet-free plasma concentrations of 5-ht , its precursors tryptophan and 5-hydroxytryptophan , and its main metabolite 5-hydroxyindoleacetic acid ( 5-hiaa ) , as well as the activities of the platelet enzymes monoamine oxi... | NA | {
"id": "C0041249",
"name": "tryptophan",
"pos": [
156,
166
]
} | {
"id": "C0000578",
"name": "5-hydroxytryptophan",
"pos": [
171,
190
]
} |
two cases of haemoperitoneum due to haemorrhage and rupture of pancreatic pseudocyst in the peritoneal cavity are reported . | NA | {
"id": "C0019065",
"name": "haemoperitoneum",
"pos": [
13,
28
]
} | {
"id": "C0019080",
"name": "haemorrhage",
"pos": [
36,
47
]
} |
increased caudate dopamine turnover may contribute to the recovery of motor function in marmosets treated with the dopaminergic neurotoxin mptp . | NA | {
"id": "C0013030",
"name": "dopamine",
"pos": [
18,
26
]
} | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
115,
127
]
} |
we studied the trophic effects of various neuropeptides , including substance p ( sp ) , thyrotropin-releasing hormone ( trh ) , neurotensin ( nt ) and bombesin ( bn ) on explanted cultures of ventral spinal cord from 13- to 14-day-old rat embryos . | NA | {
"id": "C0027895",
"name": "neuropeptides",
"pos": [
42,
55
]
} | {
"id": "C0027930",
"name": "neurotensin",
"pos": [
129,
140
]
} |
an electron microscopic study in the cat has suggested that neurons in the substantia nigra pars reticulata ( snr ) project to the medial reticular formation of the medulla oblongata ( mrf ) via the pedunculopontine tegmental nucleus ( ppn ) : ppn neurons , which were labeled with a retrograde tracer ( wga-hrp ; horser... | NA | {
"id": "C0078473",
"name": "wga-hrp",
"pos": [
304,
311
]
} | {
"id": "C0019941",
"name": "horseradish",
"pos": [
314,
325
]
} |
substance p ( sp ) , a relatively non-selective tachykinin receptor agonist , and septide and senktide , highly selective nk-1 and nk-3 tachykinin receptor agonists , respectively , were injected intradermally in rats . | NA | {
"id": "C0038585",
"name": "substance p",
"pos": [
0,
11
]
} | {
"id": "C0039241",
"name": "tachykinin",
"pos": [
136,
146
]
} |
substance p ( sp ) , a relatively non-selective tachykinin receptor agonist , and septide and senktide , highly selective nk-1 and nk-3 tachykinin receptor agonists , respectively , were injected intradermally in rats . | NA | {
"id": "C0075766",
"name": "tachykinin receptor",
"pos": [
48,
67
]
} | {
"id": "C0068603",
"name": "nk-3",
"pos": [
131,
135
]
} |
gaba ( gamma-aminobutyric acid ) and its agonists ( muscimol and baclofen ) and antagonist ( bicuculline ) were applied in the perfusion medium . | NA | {
"id": "C0016904",
"name": "gamma-aminobutyric acid",
"pos": [
7,
30
]
} | {
"id": "C0004609",
"name": "baclofen",
"pos": [
65,
73
]
} |
gaba ( 1-12.5 mm ) , muscimol ( 1-200 microm ) and ( - ) -baclofen ( 0.1-20 microm ) reduced the amplitude of the psfp in a dose-dependent manner . | NA | {
"id": "C0016904",
"name": "gaba",
"pos": [
0,
4
]
} | {
"id": "C0004609",
"name": "baclofen",
"pos": [
58,
66
]
} |
however , many other functions entail cleavage of membrane lipids to yield ( as examples ) : unsaturated fatty acids , which are converted to prostaglandins , prostacyclins , thromboxanes , and other compounds ; | NA | {
"id": "C0033554",
"name": "prostaglandins",
"pos": [
142,
156
]
} | {
"id": "C0205911",
"name": "prostacyclins",
"pos": [
159,
172
]
} |
a small but significant correlation was found between the initial refractive error and the mean annual change toward myopia . | NA | {
"id": "C0034951",
"name": "refractive error",
"pos": [
66,
82
]
} | {
"id": "C0027092",
"name": "myopia",
"pos": [
117,
123
]
} |
significant refractive error ( in 73 % ) and strabismus ( in 71 % ) were the most common ocular disorders . | NA | {
"id": "C0034951",
"name": "refractive error",
"pos": [
12,
28
]
} | {
"id": "C0015397",
"name": "ocular disorders",
"pos": [
89,
105
]
} |
these results suggest that the prevalence of aids retinopathy increases with increasing severity of hiv infection , and that cmv retinitis presents a significant vision-threatening problem in aids patients . | NA | {
"id": "C0019693",
"name": "hiv infection",
"pos": [
100,
113
]
} | {
"id": "C0001175",
"name": "aids",
"pos": [
192,
196
]
} |
by immunohistochemical methods , the authors determined the presence of extracellular matrix proteins , including fibronectin , laminin , and collagen types i , iii , iv , v , and vi , in seven corneal buttons from five patients with peters ' anomaly . | NA | {
"id": "C0079323",
"name": "extracellular matrix proteins",
"pos": [
72,
101
]
} | {
"id": "C0016055",
"name": "fibronectin",
"pos": [
114,
125
]
} |
by immunohistochemical methods , the authors determined the presence of extracellular matrix proteins , including fibronectin , laminin , and collagen types i , iii , iv , v , and vi , in seven corneal buttons from five patients with peters ' anomaly . | NA | {
"id": "C0079323",
"name": "extracellular matrix proteins",
"pos": [
72,
101
]
} | {
"id": "C0022984",
"name": "laminin",
"pos": [
128,
135
]
} |
it might be supposed that , among the antigens causing chronic immune complex glomerulonephritis ( ic gn ) , there are foreign materials , e.g . bacterial antigens penetrating the mucosal barrier . | NA | {
"id": "C0003320",
"name": "antigens",
"pos": [
38,
46
]
} | {
"id": "C0003321",
"name": "bacterial antigens",
"pos": [
145,
163
]
} |
the epitopes recognized on the mr greater than 200,000 and 38,000 antigens of s. mansoni were shown to cross-react with both the egg and the adult worm whereas those on the mr 32,000 and 20,000 antigens only cross-reacted with the adult worm , and those on the mr 15,000 antigen cross-reacted with neither the adult worm... | NA | {
"id": "C0003316",
"name": "epitopes",
"pos": [
4,
12
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
271,
278
]
} |
in addition the epitopes on the mr 38,000 and 32,000 antigens were demonstrated to be polypeptide in nature . | NA | {
"id": "C0003316",
"name": "epitopes",
"pos": [
16,
24
]
} | {
"id": "C0003320",
"name": "antigens",
"pos": [
53,
61
]
} |
immunoprecipitation with pooled antibodies absorbed with egg and adult worm homogenates which had been treated to remove either carbohydrate or polypeptide epitopes demonstrated that the mr greater than 200k antigen was the principal target of egg-cross-reactive anti-carbohydrate antibody amongst the antigens detected ... | NA | {
"id": "C0003316",
"name": "epitopes",
"pos": [
156,
164
]
} | {
"id": "C0003320",
"name": "antigens",
"pos": [
302,
310
]
} |
the mr 38 and 32k antigens were found to be precipitated by antibodies to protease-sensitive and periodate-insensitive polypeptide epitopes . | NA | {
"id": "C0003320",
"name": "antigens",
"pos": [
18,
26
]
} | {
"id": "C0003316",
"name": "epitopes",
"pos": [
131,
139
]
} |
it is unknown whether in cf sputum alpha 1-at is inactivated by oxidants , neutrophil metalloproteinases , bacterial elastase , or neutrophil elastase . | NA | {
"id": "C0030306",
"name": "elastase",
"pos": [
117,
125
]
} | {
"id": "C0064833",
"name": "neutrophil",
"pos": [
131,
141
]
} |
williams syndrome is characterized by peripheral artery stenosis such as supravalvular aortic stenosis , a distinctive dysmorphic facies , mental retardation and occasionally by transient infantile hypercalcemia . | NA | {
"id": "C0175702",
"name": "williams syndrome",
"pos": [
0,
17
]
} | {
"id": "C0003499",
"name": "supravalvular aortic stenosis",
"pos": [
73,
102
]
} |
the serum level of sfc epsilon rii in allergic children was significantly higher than that of nonallergic children in early childhood ( 1128.0 +/- 323.8 vs 777.3 +/- 227.0 pg/ml , p less than 0.01 in infants ( less than 1 y ) and 851.8 +/- 270.0 vs 579.4 +/- 197.1 pg/ml , p less than 0.05 in children aged 1-2 y ) but n... | NA | {
"id": "C0008059",
"name": "children",
"pos": [
47,
55
]
} | {
"id": "C1455726",
"name": "older children",
"pos": [
326,
340
]
} |
this cystine-depleting action of mercaptoethylgluconamide was observed with three different human cystinotic fibroblast cell lines and with all three cell lines , 2 mm mercaptoethylgluconamide was as effective as 1 mm cysteamine in depleting cells of their intracellular free cystine . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
109,
119
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
242,
247
]
} |
among 22 patients identified as having a coxsackievirus b3 infection 7 had typical herpangina and the others had pharyngitis with or without a few small vesicles . | NA | {
"id": "C0010246",
"name": "coxsackievirus",
"pos": [
41,
55
]
} | {
"id": "C0019338",
"name": "herpangina",
"pos": [
83,
93
]
} |
it may be possible to improve early case identification of children at risk for anorexia nervosa and perhaps improve intervention strategies by focusing on the early development of dieting behavior in young children . | NA | {
"id": "C0008059",
"name": "children",
"pos": [
59,
67
]
} | {
"id": "C0728836",
"name": "young children",
"pos": [
201,
215
]
} |
[ differential diagnosis of allergic and pseudoallergic variants of urticaria , quincke 's edema and neurodermatitis in children ] . | NA | {
"id": "C0042109",
"name": "urticaria",
"pos": [
68,
77
]
} | {
"id": "C0002994",
"name": "quincke 's edema",
"pos": [
80,
96
]
} |
with regard to the fracture-threshold below which the risk for non-traumatic fractures of vertebrae increases , about 60 % of hungarian women at age 50-59 and about 84 % at age 60-69 are considered to be at risk . | NA | {
"id": "C0016658",
"name": "fracture",
"pos": [
19,
27
]
} | {
"id": "C0080179",
"name": "fractures of vertebrae",
"pos": [
77,
99
]
} |
it has shown promising experimental antitumor activity against experimental murine tumors as well as continuous cell lines of human neoplastic origin and human tumor xenografts in nude mice . | NA | {
"id": "C0027659",
"name": "experimental",
"pos": [
23,
35
]
} | {
"id": "C0027651",
"name": "tumor",
"pos": [
160,
165
]
} |
( a ) southern analysis reveals that the fractions of dna fragments from chicken erythrocytes and from hen oviduct cells associated with the resistant polypeptides have a lower sequence complexity than unfractionated dna . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
54,
57
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
219,
220
]
} |
( b ) all dna fragments of the transcriptionally active and inactive ovalbumin gene map in the dna fraction passing the filters indicating that the tight dna-polypeptide complexes are not remnants of transcription complexes . | NA | {
"id": "C0919262",
"name": "b",
"pos": [
2,
3
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
154,
157
]
} |
it has been suggested that canthaxanthin ( cx ) , beta-carotene , and other carotenoids may inhibit carcinogenesis via antioxidant activity . | NA | {
"id": "C0053396",
"name": "beta-carotene",
"pos": [
50,
63
]
} | {
"id": "C0007271",
"name": "carotenoids",
"pos": [
76,
87
]
} |
the three most common inherited coagulation disorders are factor viii deficiency ( hemophilia a ) , factor ix deficiency ( hemophilia b ) , and von willebrand 's disease . | NA | {
"id": "C0852077",
"name": "inherited",
"pos": [
22,
31
]
} | {
"id": "C0019069",
"name": "hemophilia a",
"pos": [
83,
95
]
} |
the three most common inherited coagulation disorders are factor viii deficiency ( hemophilia a ) , factor ix deficiency ( hemophilia b ) , and von willebrand 's disease . | NA | {
"id": "C0852077",
"name": "inherited",
"pos": [
22,
31
]
} | {
"id": "C0008533",
"name": "hemophilia b",
"pos": [
123,
135
]
} |
the three most common inherited coagulation disorders are factor viii deficiency ( hemophilia a ) , factor ix deficiency ( hemophilia b ) , and von willebrand 's disease . | NA | {
"id": "C0852077",
"name": "inherited",
"pos": [
22,
31
]
} | {
"id": "C0042974",
"name": "von willebrand 's disease",
"pos": [
144,
169
]
} |
the rank order of the drug-induced inhibition of glucose formation from lactate , pyruvate and propionate was the following : neomycin = gentamicin greater than tobramycin greater than kanamycin = amikacin greater than streptomycin . | NA | {
"id": "C0022487",
"name": "kanamycin",
"pos": [
185,
194
]
} | {
"id": "C0002499",
"name": "amikacin",
"pos": [
197,
205
]
} |
if the latter is the case , this choroid system may serve as a model for a genetic hypomelanotic disease such as vitiligo . | NA | {
"id": "C0162835",
"name": "hypomelanotic",
"pos": [
83,
96
]
} | {
"id": "C0042900",
"name": "vitiligo",
"pos": [
113,
121
]
} |
the pregnancy continued to term and the mosaicism was confirmed in the phenotypically normal male neonate by analysis of cultured foreskin fibroblasts ( 7/49 cells + 20 ) and placental cells 20/20 cells + 20 ) whereas the peripheral lymphocytes were cytogenetically normal ( 20/20 cells were 46 , xy ) . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
139,
150
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
281,
286
]
} |
transabdominal chorionic villus sampling in the second trimester of pregnancy : feto-maternal transfusions in relation to pregnancy outcome . | NA | {
"id": "C0032980",
"name": "second trimester",
"pos": [
48,
64
]
} | {
"id": "C0032961",
"name": "pregnancy",
"pos": [
122,
131
]
} |
volumes of feto-maternal transfusions ( fmts ) in transabdominal chorionic villus sampling ( tacvs ) in the second trimester of pregnancy were calculated from the difference between maternal alpha-fetoprotein ( afp ) concentrations before and 1 h after tacvs . | NA | {
"id": "C0032980",
"name": "second trimester",
"pos": [
108,
124
]
} | {
"id": "C0032961",
"name": "pregnancy",
"pos": [
128,
137
]
} |
photoaffinity crosslinking of stmpm surface proteins in situ to monomeric rabbit derivatized with n-succinimidyl ( 4-azidophenyl ) -i , 3-dithiopropionate identified igg-binding proteins identical in size to pibp56 and pibp40 . | NA | {
"id": "C0025252",
"name": "surface proteins",
"pos": [
36,
52
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
178,
186
]
} |
among the clinical forms , only infiltrative tuberculosis ( 88.9 per cent ) and tuberculoma ( 11.1 per cent ) were diagnosed . | NA | {
"id": "C0041296",
"name": "tuberculosis",
"pos": [
45,
57
]
} | {
"id": "C0041295",
"name": "tuberculoma",
"pos": [
80,
91
]
} |
in this connection it was recommended that thorough clinical and bronchological examinations for silicotuberculosis of adenogenic genesis be performed in all the cases with progressing silicosis . | NA | {
"id": "C0037118",
"name": "silicotuberculosis",
"pos": [
97,
115
]
} | {
"id": "C0037116",
"name": "silicosis",
"pos": [
185,
194
]
} |
the enzyme was dependent on adenosylcobalamin or methylcobalamin but not on cobalamin , cyanocobalamin , or hydroxocobalamin in either the absence or presence of s-adenosylmethionine . | NA | {
"id": "C0042845",
"name": "cyanocobalamin",
"pos": [
88,
102
]
} | {
"id": "C0020316",
"name": "hydroxocobalamin",
"pos": [
108,
124
]
} |
host-serum proteins demonstrated by immunodiffusion within tcvf ( albumin , transferrin , igg , and another five noncharacterized proteins ) , tccwe ( albumin , igg , and six additional unknown proteins ) , tsvf ( albumin ) and tscwe ( albumin and igg ) were removed by immunoaffinity chromatography prior to immunoelect... | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
11,
19
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
236,
243
]
} |
milk xanthine oxidase purified by a procedure that includes anion-exchange chromatography is shown to contain three phosphate residues . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
60,
65
]
} | {
"id": "C0031603",
"name": "phosphate",
"pos": [
116,
125
]
} |
using a plasma-free assay of the ability of activated fviii to function as a cofactor in the activation of factor x by factor ixa , we found that fviii is activated by the venom enzyme . | NA | {
"id": "C0015514",
"name": "activated fviii",
"pos": [
44,
59
]
} | {
"id": "C0015506",
"name": "fviii",
"pos": [
146,
151
]
} |
these results suggest that the binding of fviii to von willebrand factor depends on the presence of an intact light chain and that activated fviii must dissociate from von willebrand factor to exert its cofactor effect . | NA | {
"id": "C0015506",
"name": "fviii",
"pos": [
42,
47
]
} | {
"id": "C0015514",
"name": "activated fviii",
"pos": [
131,
146
]
} |
we report that cellular proteins react with a labeled rna probe representing the 5 ' terminus of a subset of this rna but not with the complementary strand of this rna . | NA | {
"id": "C0035683",
"name": "rna probe",
"pos": [
54,
63
]
} | {
"id": "C0056208",
"name": "complementary",
"pos": [
135,
148
]
} |
quantitative hybridization selection/depletion experiments with clones of rrna-encoding dna ( rdna ) and cross-linked nuclear rna showed that all of the cross-linked u3 rna was associated with a region that includes the external transcribed spacer ( ets ) at the 5 ' end of the human rrna precursor . | NA | {
"id": "C0035701",
"name": "rrna",
"pos": [
74,
78
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
285,
288
]
} |
quantitative hybridization selection/depletion experiments with clones of rrna-encoding dna ( rdna ) and cross-linked nuclear rna showed that all of the cross-linked u3 rna was associated with a region that includes the external transcribed spacer ( ets ) at the 5 ' end of the human rrna precursor . | NA | {
"id": "C0035700",
"name": "nuclear rna",
"pos": [
118,
129
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
285,
288
]
} |
a family of oligonucleotides and phosphorothioate oligonucleotide analogues was synthesized with a cholesteryl group tethered at the 3'-terminal internucleoside link . | NA | {
"id": "C0028953",
"name": "oligonucleotides",
"pos": [
12,
28
]
} | {
"id": "C1519059",
"name": "phosphorothioate oligonucleotide",
"pos": [
33,
65
]
} |
it was established that no covalent drug-dna adduct was formed during the incubation of the drug with dna or during subsequent incubation with the uvrab proteins . | NA | {
"id": "C0242958",
"name": "drug-dna adduct",
"pos": [
36,
51
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
102,
105
]
} |
competitive binding studies reveal the appropriate a2 receptor pharmacologic potency order with 5'-n-ethylcarboxamidoadenosine ( neca ) greater than ( - ) -n6- [ ( r ) -1-methyl- 2-phenylethyl ] adenosine ( r-pia ) greater than ( + ) -n6- [ ( s ) -1-methyl-2- phenylethyl ] adenosine ( s-pia ) . | NA | {
"id": "C0050789",
"name": "n-ethylcarboxamidoadenosine",
"pos": [
99,
126
]
} | {
"id": "C0001443",
"name": "adenosine",
"pos": [
274,
283
]
} |
pathway of proton transfer in bacterial reaction centers : replacement of glutamic acid 212 in the l subunit by glutamine inhibits quinone ( secondary acceptor ) turnover . | NA | {
"id": "C0061472",
"name": "glutamic acid",
"pos": [
74,
87
]
} | {
"id": "C0017797",
"name": "glutamine",
"pos": [
112,
121
]
} |
replacement of glu-212 of the l subunit , a protonatable residue located near the secondary acceptor ( qb ) binding site , by glutamine reduced the in vitro electron turnover from cytochrome c to 2,3-dimethoxy-5-methylbenzoquinone ( uq0 ) by a factor of 25 . | NA | {
"id": "C0061472",
"name": "glu",
"pos": [
15,
18
]
} | {
"id": "C0017797",
"name": "glutamine",
"pos": [
126,
135
]
} |
the amino acid sequences of the 70- and 60-kda subunits of the vacuolar h+-atpase are approximately equal to 25 % identical to the beta and alpha subunits , respectively , of the eubacterial-type f0f1-atpases . | NA | {
"id": "C0379099",
"name": "vacuolar h",
"pos": [
63,
73
]
} | {
"id": "C0018437",
"name": "f0f1-atpases",
"pos": [
196,
208
]
} |
the implication is that the vacuolar h+-atpase of eukaryotes arose by the internalization of the plasma membrane h+-atpase of an archaebacterial-like ancestral cell . | NA | {
"id": "C0379099",
"name": "vacuolar h",
"pos": [
28,
38
]
} | {
"id": "C0018437",
"name": "h",
"pos": [
132,
133
]
} |
this enhancer is active on both a tcr v alpha ( variable region alpha chain ) promoter and the minimal simian virus 40 promotor in tcr alpha/beta jurkat and el4 cells but is inactive on a v alpha promoter in human tcr gamma/delta peer and molt-13 cells , clone 13 b cells , and hela fibroblasts . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
161,
166
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
283,
294
]
} |
antibodies elicited by peptides from one isolate do not neutralize two different isolates , and a hybrid peptide , consisting of amino acid sequences from two isolates , elicits neutralizing antibodies to both isolates . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
0,
10
]
} | {
"id": "C0475463",
"name": "neutralizing antibodies",
"pos": [
178,
201
]
} |
the effects of phenotype and sex on serum and lipoprotein lipid content were examined in la/n-cp rats fed either a control or an atherogenic diet high in saturated fat and protein . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
46,
57
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
58,
63
]
} |
dopa concentrations in plasma have been used to reflect the activity of tyrosine hydroxylase , the rate-limiting enzyme in the synthesis of catecholamines . | NA | {
"id": "C0013023",
"name": "dopa",
"pos": [
0,
4
]
} | {
"id": "C0007412",
"name": "catecholamines",
"pos": [
140,
154
]
} |
in this study dopa and its major metabolites ( 3-o-methyldopa and free and conjugated catecholamines ) were measured in plasma of dogs during 5 hr after feeding . | NA | {
"id": "C0013023",
"name": "dopa",
"pos": [
14,
18
]
} | {
"id": "C0007412",
"name": "catecholamines",
"pos": [
86,
100
]
} |
studied by first trimester chorionic villus sampling it has been reported in about 1-2 % of human gestations . | NA | {
"id": "C0032979",
"name": "first trimester",
"pos": [
11,
26
]
} | {
"id": "C0032961",
"name": "gestations",
"pos": [
98,
108
]
} |
the aldehyde residues of thermolabile urological instruments , after the formaldehyde sterilization or sterilization in aseptic preparation from a 2 % glutaraldehyde solution will be examined and compared . | NA | {
"id": "C0001992",
"name": "aldehyde",
"pos": [
4,
12
]
} | {
"id": "C0017814",
"name": "glutaraldehyde",
"pos": [
151,
165
]
} |
it is concluded that after sterilization in the 2 % glutaraldehyde solution , the glutaraldehyde residues on the experimental materials are safe . | NA | {
"id": "C0991687",
"name": "2",
"pos": [
48,
49
]
} | {
"id": "C0017814",
"name": "glutaraldehyde",
"pos": [
82,
96
]
} |
in the present study , rabbits prepared with chronic vascular cannulae were used to study the effects of nicotine administration on plasma corticosterone , catecholamine ( epinephrine , norepinephrine and dopamine ) and glucose responses to physical restraint stress . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
172,
183
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
186,
200
]
} |
independent administration of nicotine , or the application of the physical restraint stressor , resulted in increases in the plasma concentrations of corticosterone , epinephrine , norepinephrine , and glucose . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
168,
179
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
182,
196
]
} |
changes in etoh-induced narcosis produced by bicuculline were accompanied by changes in blood ethanol concentrations consistent with an hypothesis of altered central nervous system sensitivity to etoh . | NA | {
"id": "C0684262",
"name": "blood ethanol concentrations",
"pos": [
88,
116
]
} | {
"id": "C0001962",
"name": "etoh",
"pos": [
196,
200
]
} |
when gamma-irradiated sv40 dna was exposed to ph 7.2 or 9.6 elution buffer prior to analysis by gel electrophoresis , a significantly greater number of dna dsbs were detected in the dna exposed to ph 9.6 . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
6,
7
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
182,
185
]
} |
complications of studying ultrasoft x rays can be minimized in this context by using cells with very thin cytoplasm and nuclei ( e.g. , less than the attenuation length of the x rays ) , and which exhibit a more nearly exponential dose response to cell killing , such as normal human fibroblasts compared with v79 cells ... | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
284,
295
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
314,
319
]
} |
histochemical demonstration of 7,9-disubstituted sialic acids : strong periodate oxidation of sialic acid mixtures on the biochemical and histochemical level . | NA | {
"id": "C0037025",
"name": "sialic acids",
"pos": [
49,
61
]
} | {
"id": "C0067762",
"name": "sialic acid",
"pos": [
94,
105
]
} |
the actin-capping capacity of svs ii indicates the functional relation of this immunoreactive membrane protein with actin or an actinrelated protein . | NA | {
"id": "C0025252",
"name": "membrane protein",
"pos": [
94,
110
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
141,
148
]
} |
leukotrienes d4 , e4 , b4 , oxidized glutathione ( gssg ) , cysteine , and mercaptoethanol were unable to displace 3h-ltc4 at 1 microm concentrations , while gsh inhibited binding with a ki of 47 nm . | NA | {
"id": "C0061516",
"name": "gssg",
"pos": [
51,
55
]
} | {
"id": "C0017817",
"name": "gsh",
"pos": [
158,
161
]
} |
the tachykinins induced vasodilatation in a dose-response manner with a threshold of approximately 3 pmol and pd2 's of 6.48 , 6.13 and 6.21 for sp , neurokinin a and neurokinin b respectively . | NA | {
"id": "C0039241",
"name": "tachykinins",
"pos": [
4,
15
]
} | {
"id": "C0038585",
"name": "sp",
"pos": [
182,
184
]
} |
the tachykinins induced vasodilatation in a dose-response manner with a threshold of approximately 3 pmol and pd2 's of 6.48 , 6.13 and 6.21 for sp , neurokinin a and neurokinin b respectively . | NA | {
"id": "C0039241",
"name": "tachykinins",
"pos": [
4,
15
]
} | {
"id": "C0038581",
"name": "neurokinin a",
"pos": [
150,
162
]
} |
the tachykinins induced vasodilatation in a dose-response manner with a threshold of approximately 3 pmol and pd2 's of 6.48 , 6.13 and 6.21 for sp , neurokinin a and neurokinin b respectively . | NA | {
"id": "C0039241",
"name": "tachykinins",
"pos": [
4,
15
]
} | {
"id": "C0027847",
"name": "neurokinin b",
"pos": [
167,
179
]
} |
a methodology for using physiologically based pharmacokinetic ( pbpk ) models to derive predicted safe concentrations of noncarcinogens in drinking water for humans based on experimentally determined no observed adverse effect levels ( noaels ) in animals is presented and applied to the case of 1,1,1-trichloroethane ( ... | NA | {
"id": "C0040904",
"name": "trichloroethane",
"pos": [
302,
317
]
} | {
"id": "C0043697",
"name": "methyl chloroform",
"pos": [
320,
337
]
} |
described are the deleterious side effects on hemodynamic stability and patient comfort of an intramyometrically administered synthetic prostaglandin e ( pge2 ) -compound ( dinoprostone ) given to three female patients under high epidural anesthesia during cesarean section . | NA | {
"id": "C0033559",
"name": "prostaglandin e",
"pos": [
136,
151
]
} | {
"id": "C0012472",
"name": "dinoprostone",
"pos": [
173,
185
]
} |
it may be the treatment of choice in severe lupus characterized by ongoing antibody or immune-complex mediated tissue injury . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
75,
83
]
} | {
"id": "C0003313",
"name": "immune-complex",
"pos": [
87,
101
]
} |
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