text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
the hvd infection was confirmed in 39.4 % of the hbs ag positive acute hepatitis , being in the majority of the cases delta coinfections with a clinical and biochemical evolution similar to the hepatitis caused by the b virus only . | NA | {
"id": "C0009450",
"name": "infection",
"pos": [
8,
17
]
} | {
"id": "C0275524",
"name": "coinfections",
"pos": [
124,
136
]
} |
two thirds of this mortality are related to infectious and parasitic diseases : measles , diarrhoea , respiratory diseases and malaria . | NA | {
"id": "C0009450",
"name": "infectious",
"pos": [
44,
54
]
} | {
"id": "C0030499",
"name": "parasitic diseases",
"pos": [
59,
77
]
} |
the variables studied were : height , weight , skin fold , blood pressure , lipids , lipoproteins , glycemia , uric acid and tobacco habit . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
76,
82
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
85,
97
]
} |
this finding has not been described , to our knowledge , in the cor triatriatum nor in any other cardiac abnormality . | NA | {
"id": "C0009995",
"name": "cor triatriatum",
"pos": [
64,
79
]
} | {
"id": "C0018798",
"name": "cardiac abnormality",
"pos": [
97,
116
]
} |
mptp and mpp+ injections ( 20 mg/kg i.p . ) caused a marked acute depletion of heart noradrenaline , up to 75 % twelve hours after the administration , and a decrease of adrenal gland adrenaline . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
85,
98
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
184,
194
]
} |
analogues of e-type prostaglandins , such as arbaprostil , enprostil , misoprostol , rioprostil , and trimoprostil , suppress gastric acid secretion and ( like native e-type prostaglandins ) the chemically modified analogues enhance a number of gastroduodenal mucosal defence factors . | NA | {
"id": "C0033560",
"name": "analogues",
"pos": [
0,
9
]
} | {
"id": "C0003719",
"name": "arbaprostil",
"pos": [
45,
56
]
} |
analogues of e-type prostaglandins , such as arbaprostil , enprostil , misoprostol , rioprostil , and trimoprostil , suppress gastric acid secretion and ( like native e-type prostaglandins ) the chemically modified analogues enhance a number of gastroduodenal mucosal defence factors . | NA | {
"id": "C0033560",
"name": "analogues",
"pos": [
0,
9
]
} | {
"id": "C0085191",
"name": "enprostil",
"pos": [
59,
68
]
} |
analogues of e-type prostaglandins , such as arbaprostil , enprostil , misoprostol , rioprostil , and trimoprostil , suppress gastric acid secretion and ( like native e-type prostaglandins ) the chemically modified analogues enhance a number of gastroduodenal mucosal defence factors . | NA | {
"id": "C0033560",
"name": "analogues",
"pos": [
0,
9
]
} | {
"id": "C0085199",
"name": "rioprostil",
"pos": [
85,
95
]
} |
for the purpose , the compound , previously hydrolyzed with bicarbonate-carbonate buffer or with microsomal enzymes was put in contact with alpha 1-at and exposed to gas phase cigarette smoke . | NA | {
"id": "C0005367",
"name": "bicarbonate",
"pos": [
60,
71
]
} | {
"id": "C0007026",
"name": "carbonate",
"pos": [
72,
81
]
} |
previously expressed theories had linked microlithiasis to external irritants and the condition has similarities with desert lung syndrome , a disease definitely caused by the deposition of sand silica in the lungs . | NA | {
"id": "C0039082",
"name": "syndrome",
"pos": [
130,
138
]
} | {
"id": "C0012634",
"name": "disease",
"pos": [
143,
150
]
} |
a review of the world literature on the penetration ( ratio of concentrations of cerebrospinal fluid to concentrations of serum ) and attainable antibiotic concentrations in the cerebrospinal fluid in humans for cefuroxime , cefoxitin , cefotaxime , ceftizoxime , cefmenoxime , cefamandole , cefoperazone , moxalactam , ... | NA | {
"id": "C0007562",
"name": "cefuroxime",
"pos": [
212,
222
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
237,
247
]
} |
a review of the world literature on the penetration ( ratio of concentrations of cerebrospinal fluid to concentrations of serum ) and attainable antibiotic concentrations in the cerebrospinal fluid in humans for cefuroxime , cefoxitin , cefotaxime , ceftizoxime , cefmenoxime , cefamandole , cefoperazone , moxalactam , ... | NA | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
237,
247
]
} | {
"id": "C0007560",
"name": "ceftizoxime",
"pos": [
250,
261
]
} |
a review of the world literature on the penetration ( ratio of concentrations of cerebrospinal fluid to concentrations of serum ) and attainable antibiotic concentrations in the cerebrospinal fluid in humans for cefuroxime , cefoxitin , cefotaxime , ceftizoxime , cefmenoxime , cefamandole , cefoperazone , moxalactam , ... | NA | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
237,
247
]
} | {
"id": "C0007549",
"name": "cefmenoxime",
"pos": [
264,
275
]
} |
a review of the world literature on the penetration ( ratio of concentrations of cerebrospinal fluid to concentrations of serum ) and attainable antibiotic concentrations in the cerebrospinal fluid in humans for cefuroxime , cefoxitin , cefotaxime , ceftizoxime , cefmenoxime , cefamandole , cefoperazone , moxalactam , ... | NA | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
237,
247
]
} | {
"id": "C0007561",
"name": "ceftriaxone",
"pos": [
338,
349
]
} |
a review of the world literature on the penetration ( ratio of concentrations of cerebrospinal fluid to concentrations of serum ) and attainable antibiotic concentrations in the cerebrospinal fluid in humans for cefuroxime , cefoxitin , cefotaxime , ceftizoxime , cefmenoxime , cefamandole , cefoperazone , moxalactam , ... | NA | {
"id": "C0007541",
"name": "cefamandole",
"pos": [
278,
289
]
} | {
"id": "C0007552",
"name": "cefoperazone",
"pos": [
406,
418
]
} |
for the treatment of common meningeal pathogens ( streptococcus pneumoniae , haemophilus influenzae , and neisseria meningitidis ) and for gram-negative bacilli , mainly escherichia coli and klebsiella ( excluding pseudomonas aeruginosa ) , the cefotaxime-ceftriaxone group of cephalosporins has accrued the most clinica... | NA | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
245,
255
]
} | {
"id": "C0007561",
"name": "ceftriaxone",
"pos": [
256,
267
]
} |
pneumonia of unknown etiology and aspiration pneumonia were more common and mycoplasma pneumoniae infection less common among those with nursing home-acquired pneumonia . | NA | {
"id": "C0032290",
"name": "aspiration",
"pos": [
34,
44
]
} | {
"id": "C0032285",
"name": "pneumonia",
"pos": [
159,
168
]
} |
ciprofloxacin has been the quinolone studied most thoroughly , and few data are available about the combination of other quinolones with other antimicrobial agents . | NA | {
"id": "C1533693",
"name": "quinolone",
"pos": [
27,
36
]
} | {
"id": "C1136254",
"name": "antimicrobial agents",
"pos": [
143,
163
]
} |
published reports indicate that penetration into all sites , including intracellular sites , is high and exceeds that achievable for other commonly used antimicrobial agents , including penicillins , cephalosporins , and aminoglycosides . | NA | {
"id": "C1136254",
"name": "antimicrobial agents",
"pos": [
153,
173
]
} | {
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
221,
236
]
} |
differences between the pharmacokinetics of the new fluoroquinolones in the young and in the elderly have been demonstrated for ciprofloxacin , enoxacin , norfloxacin , and ofloxacin . | NA | {
"id": "C0949665",
"name": "fluoroquinolones",
"pos": [
52,
68
]
} | {
"id": "C0008809",
"name": "ciprofloxacin",
"pos": [
128,
141
]
} |
differences between the pharmacokinetics of the new fluoroquinolones in the young and in the elderly have been demonstrated for ciprofloxacin , enoxacin , norfloxacin , and ofloxacin . | NA | {
"id": "C0949665",
"name": "fluoroquinolones",
"pos": [
52,
68
]
} | {
"id": "C0014310",
"name": "enoxacin",
"pos": [
144,
152
]
} |
differences between the pharmacokinetics of the new fluoroquinolones in the young and in the elderly have been demonstrated for ciprofloxacin , enoxacin , norfloxacin , and ofloxacin . | NA | {
"id": "C0949665",
"name": "fluoroquinolones",
"pos": [
52,
68
]
} | {
"id": "C0028365",
"name": "norfloxacin",
"pos": [
155,
166
]
} |
differences between the pharmacokinetics of the new fluoroquinolones in the young and in the elderly have been demonstrated for ciprofloxacin , enoxacin , norfloxacin , and ofloxacin . | NA | {
"id": "C0949665",
"name": "fluoroquinolones",
"pos": [
52,
68
]
} | {
"id": "C0028902",
"name": "ofloxacin",
"pos": [
173,
182
]
} |
the new fluoroquinolones have been shown to be active against shigella in vitro and effective for the treatment of shigellosis in adults , but concern about the safety of quinolones has so far prevented the evaluation of these agents for the treatment of shigellosis in young children . | NA | {
"id": "C0949665",
"name": "fluoroquinolones",
"pos": [
8,
24
]
} | {
"id": "C0034428",
"name": "quinolones",
"pos": [
171,
181
]
} |
those agents with an mic of less than 2.0 mg/l may be of clinical value , and clinical trials have been conducted with ciprofloxacin , ofloxacin , and fleroxacin . | NA | {
"id": "C0008809",
"name": "ciprofloxacin",
"pos": [
119,
132
]
} | {
"id": "C0085161",
"name": "fleroxacin",
"pos": [
151,
161
]
} |
the newer quinolones ( ciprofloxacin , enoxacin , norfloxacin , ofloxacin , pefloxacin , and fleroxacin ) cover the spectrum of gram-positive and gram-negative bacteria causing urinary tract infections , including complicated and nosocomial infections and those caused by multiresistant strains . | NA | {
"id": "C0008809",
"name": "ciprofloxacin",
"pos": [
23,
36
]
} | {
"id": "C0085161",
"name": "fleroxacin",
"pos": [
93,
103
]
} |
some of the newer quinolone derivatives ( e.g. , ciprofloxacin , enoxacin , fleroxacin , ofloxacin , pefloxacin , and amifloxacin ) can be administered intravenously . | NA | {
"id": "C0008809",
"name": "ciprofloxacin",
"pos": [
49,
62
]
} | {
"id": "C0085161",
"name": "fleroxacin",
"pos": [
76,
86
]
} |
the mean albumin , iga and igg levels were lower in the dysmature infants probably due to immaturity of the elements that synthesize these proteins , i.e . accelerate protein metabolism . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
9,
16
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
139,
147
]
} |
there have been numerous reports of adverse reactions , including urticaria , angioneurotic edema , asthma an anaphylaxis following the ingestion of food additives such as tartrazine , monosodium glutamate and benzoic acid . | NA | {
"id": "C0042109",
"name": "urticaria",
"pos": [
66,
75
]
} | {
"id": "C0002994",
"name": "angioneurotic edema",
"pos": [
78,
97
]
} |
hereditary angioedema ( hae ) is an inherited deficiency of the inhibitor of c1 esterase ( c1 inh ) . | NA | {
"id": "C0019243",
"name": "hae",
"pos": [
24,
27
]
} | {
"id": "C2717905",
"name": "deficiency of",
"pos": [
46,
59
]
} |
the overall prevalence of s. haematobium infection was 26 % and of s. mansoni was 15 % , while 7 % of the population sampled had mixed infections . | NA | {
"id": "C0009450",
"name": "infection",
"pos": [
41,
50
]
} | {
"id": "C0275524",
"name": "mixed infections",
"pos": [
129,
145
]
} |
urinary excretion of the collagen-specific amino acids hydroxyproline and hydroxylysine , and of proline was used as a guideline for monitoring the bioavailability of d-penicillamine . | NA | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
55,
69
]
} | {
"id": "C0033382",
"name": "proline",
"pos": [
97,
104
]
} |
the value obtained for heavy-metal levels ( pb , cd , hg ) indicated that there is a significant difference between the groups of found-dead and slaughtered calves from the nymburk region ( muscle -- pb , cd ; liver -- pb ; kidney -- pb , cd ) . | NA | {
"id": "C0347988",
"name": "heavy-metal",
"pos": [
23,
34
]
} | {
"id": "C0025424",
"name": "hg",
"pos": [
54,
56
]
} |
seven heavy metals , co , cr , cu , fe , mn , ni and zn , were measured in marine sediments , plants and invertebrates in the vicinity of a ferro-nickel smelting plant in greece . | NA | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
6,
18
]
} | {
"id": "C0028013",
"name": "smelting",
"pos": [
153,
161
]
} |
the complementary dna sequence of kgf demonstrates that it is a member of the fibroblast growth factor family . | NA | {
"id": "C0064294",
"name": "kgf",
"pos": [
34,
37
]
} | {
"id": "C0016026",
"name": "fibroblast growth factor",
"pos": [
78,
102
]
} |
the messenger rnas specifying certain proteins involved in the inflammatory response and certain oncoproteins contain a conserved ua-rich sequence in the 3 ' untranslated region . | NA | {
"id": "C0035696",
"name": "messenger rnas",
"pos": [
4,
18
]
} | {
"id": "C0600680",
"name": "untranslated region",
"pos": [
158,
177
]
} |
an authentic human hemoglobin was formed in adult erythrocytes that when purified had an oxygen equilibrium curve identical to the curve of native human hemoglobin a ( hb a ) . | NA | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
19,
29
]
} | {
"id": "C0019016",
"name": "hemoglobin a",
"pos": [
153,
165
]
} |
exposure of eukaryotic cells transfected with this gene to adrenaline or noradrenaline promotes the accumulation of adenosine 3',5'-monophosphate ; | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
59,
69
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
73,
86
]
} |
however , our practice has been to try to avoid methotrexate in patients with diabetes , prior liver disease , alcoholism , or obesity because of previous reports suggesting that these patients are at increased risk for the development of cirrhosis . | NA | {
"id": "C0023895",
"name": "liver disease",
"pos": [
95,
108
]
} | {
"id": "C0023890",
"name": "cirrhosis",
"pos": [
239,
248
]
} |
the authors examined a total of 172 blood traces on cloth from pregnancies of different stages ( 37 from the first trimester , 34 from the beginning of the second half of pregnancies and 101 at term ) as extracts from the blood stain or particles of the blood stains on a slide . | NA | {
"id": "C0032979",
"name": "first trimester",
"pos": [
109,
124
]
} | {
"id": "C0032961",
"name": "pregnancies",
"pos": [
171,
182
]
} |
among 6 igg1 mab , four were a. cantonensis-specific , of which three reacted to adult worm antigen only and one reacted to both adult worm and juvenile worm antigens . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
92,
99
]
} | {
"id": "C0003331",
"name": "worm antigens",
"pos": [
153,
166
]
} |
a penicillinase test incorporated in the rapid carbohydrate fermentation method for rapid detection of beta-lactamase producing neisseria gonorrhoeae . | NA | {
"id": "C0030841",
"name": "penicillinase",
"pos": [
2,
15
]
} | {
"id": "C0597979",
"name": "beta-lactamase",
"pos": [
103,
117
]
} |
in our experience , 46 of 51 patients with massively enlarged spleens had a myeloproliferative disorder ( leukemia , lymphoma or agnogenic myeloid metaplasia ) and usually had a limited life expectancy . | NA | {
"id": "C0027022",
"name": "myeloproliferative disorder",
"pos": [
76,
103
]
} | {
"id": "C0001815",
"name": "agnogenic myeloid metaplasia",
"pos": [
129,
157
]
} |
fetal weight , crown-rump length , placental weight , and maternal gestational weight gain were reduced in a dose-dependent manner following combined preconceptional and gestational exposure . | NA | {
"id": "C0751992",
"name": "fetal weight",
"pos": [
0,
12
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
79,
85
]
} |
neonatal rats were exposed to 6.6 g/kg of alcohol each day between postnatal days 4 and 10 while artificial-rearing procedures were used , in a manner which produced high peak and low trough blood alcohol concentrations each day . | NA | {
"id": "C0001962",
"name": "alcohol",
"pos": [
42,
49
]
} | {
"id": "C0684262",
"name": "blood alcohol concentrations",
"pos": [
191,
219
]
} |
two patients from group 1 had a cough , six patients ( four from group 2 ) had contact bleeding at bronchoscopy , and two further patients had haemoptysis . | NA | {
"id": "C0019080",
"name": "bleeding",
"pos": [
87,
95
]
} | {
"id": "C0019079",
"name": "haemoptysis",
"pos": [
143,
154
]
} |
to determine whether bronchial reactivity to histamine is increased in hyperthyroidism 10 thyrotoxic non-asthmatic patients were assessed before and after treatment of their thyrotoxicosis . | NA | {
"id": "C0020550",
"name": "hyperthyroidism",
"pos": [
71,
86
]
} | {
"id": "C0040156",
"name": "thyrotoxicosis",
"pos": [
174,
188
]
} |
serum potassium concentrations were measured before , during , and after exercise in 32 patients with asthma ( 12 with exercise induced asthma ) , and in seven normal subjects . | NA | {
"id": "C0004096",
"name": "asthma",
"pos": [
102,
108
]
} | {
"id": "C0004099",
"name": "exercise induced asthma",
"pos": [
119,
142
]
} |
the glycosaminoglycans heparin , org 10172 , fragmin and the pentasaccharide , representing the at-iii binding sequence of heparin , were active in both models . | NA | {
"id": "C0017973",
"name": "glycosaminoglycans",
"pos": [
4,
22
]
} | {
"id": "C0019134",
"name": "heparin",
"pos": [
123,
130
]
} |
in contrast , the lipoxygenase inhibitor nordihydroguaiaretic acid ( ndga , 10 microm ) , the ca2+-chelating anticoagulants trisodium citrate ( 10 microm ) and edetate disodium ( edta , 5.4 mm ) as well as the functionally unrelated heparin ( 20 iu/ml ) significantly inhibited the formation of cysteinyl-lt as well as o... | NA | {
"id": "C0012695",
"name": "edetate disodium",
"pos": [
160,
176
]
} | {
"id": "C0013618",
"name": "edta",
"pos": [
179,
183
]
} |
here , removal of drinking water resulted in increased intercellular deposition of mgb contents , and tewl progressively decreased . | NA | {
"id": "C0599638",
"name": "drinking water",
"pos": [
18,
32
]
} | {
"id": "C0043047",
"name": "tewl",
"pos": [
102,
106
]
} |
to clarify the clinical significance of specific plasma amino acid abnormalities occurring in liver disorders with portal-systemic shunting , plasma amino acids and insulin levels were measured in idiopathic portal hypertension ( iph ) , extrahepatic portal occulusion ( ehpo ) , and liver cirrhosis ( lc ) . | NA | {
"id": "C0023895",
"name": "liver disorders",
"pos": [
94,
109
]
} | {
"id": "C0023890",
"name": "liver cirrhosis",
"pos": [
284,
299
]
} |
three branched chain amino acids ( bcaa : valine + leucine + isoleucine ) were decreased in all three diseases in comparison with controls . | NA | {
"id": "C0002521",
"name": "branched",
"pos": [
6,
14
]
} | {
"id": "C0042285",
"name": "valine",
"pos": [
42,
48
]
} |
cisplatin induced a decrease in cytochrome p-450 , gsh , gsh s-transferase , gsh reductase and gsh peroxidase activities , and an increase in n-glucuronyl transferase , lipid peroxidation and oxidized glutathione ( gssg ) in kidney cortical microsomes and cytosolic fractions . | NA | {
"id": "C0017817",
"name": "gsh",
"pos": [
51,
54
]
} | {
"id": "C0061516",
"name": "gssg",
"pos": [
215,
219
]
} |
[ morphology of fractures of long tubular bones in children upon trauma due to solid blunt objects ] . | NA | {
"id": "C0016658",
"name": "of fractures",
"pos": [
13,
25
]
} | {
"id": "C0043251",
"name": "trauma",
"pos": [
65,
71
]
} |
the following methods for furosemide identification were recommended : microcrystalline reactions with dragendorf and zonnenstein reagents , with cuprous iodide and ferric iodide complexes , rhodanide cadmium complex , plumbous iodide solution in iodized potassium , and thin-layer sorbent chromatography . | NA | {
"id": "C0021966",
"name": "iodide",
"pos": [
154,
160
]
} | {
"id": "C0032831",
"name": "iodide",
"pos": [
228,
234
]
} |
in contrast , precursors of secreted and membrane proteins have apolar segments which are recognized by chaperones and membrane receptors to distinguish them from soluble proteins . | NA | {
"id": "C0025252",
"name": "membrane proteins",
"pos": [
41,
58
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
171,
179
]
} |
in contrast , precursors of secreted and membrane proteins have apolar segments which are recognized by chaperones and membrane receptors to distinguish them from soluble proteins . | NA | {
"id": "C0243041",
"name": "chaperones",
"pos": [
104,
114
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
171,
179
]
} |
although each of these repressor proteins belongs to the 'helix-turn-helix ' class of dna-binding proteins , they do not use a simple code for recognition . | NA | {
"id": "C0035147",
"name": "repressor proteins",
"pos": [
23,
41
]
} | {
"id": "C0012940",
"name": "dna-binding",
"pos": [
86,
97
]
} |
the ability of the extracellular matrix protein laminin to regulate the survival and differentiation of neurons has led to the search for a neuronal laminin receptor . | NA | {
"id": "C0079323",
"name": "extracellular matrix protein",
"pos": [
19,
47
]
} | {
"id": "C0022984",
"name": "laminin",
"pos": [
149,
156
]
} |
the local transverse displacements of the cell surface within the frequency range of 0.2-30 hz occur on animal cells attached to cover glass : fibroblasts 3t6 , primary culture of rat cardiomyocytes , mouse lymphocytes , human macrophages and erythrocytes , frog erythrocytes . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
111,
116
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
143,
154
]
} |
four patients refractory to doxorubicin ( dx ) and 9 patients refractory to 4'epidoxorubicin ( 4'epidx ) were treated with verapamil ( vrp ) ( 120 mg every 6 h for 3 days ) plus 4'epidx ( 80 mg/m2 i.v . bolus , together with the 6th vrp administration ) . | NA | {
"id": "C0013089",
"name": "doxorubicin",
"pos": [
28,
39
]
} | {
"id": "C0014582",
"name": "epidoxorubicin",
"pos": [
78,
92
]
} |
nine patients ( 5 males , 4 females ; median age , 62 years ) with recurrent high-grade malignancies of major ( 7 cases ) and minor ( 2 cases ) salivary gland origin ( 4 adenoid cystic carcinomas , 2 adenocarcinomas , 2 poorly differentiated carcinomas , 1 mixed malignant tumor ) were treated with cisplatin ( 60 mg/m2 ... | NA | {
"id": "C0010606",
"name": "adenoid cystic carcinomas",
"pos": [
170,
195
]
} | {
"id": "C0001418",
"name": "adenocarcinomas",
"pos": [
200,
215
]
} |
some evidence is assembled to suggest that trench fever , an infection with a strain of rochalimaea , if not quintana , then vinsonii , was present in belfast in the first half of the nineteenth century in endemic and epidemic form . | NA | {
"id": "C0040830",
"name": "trench fever",
"pos": [
43,
55
]
} | {
"id": "C0004771",
"name": "infection",
"pos": [
61,
70
]
} |
the trypanosoma stocks isolated from these two camels were screened for isoenzyme patterns of 10 enzymes using thin-layer starch-gel electrophoresis . | NA | {
"id": "C0022173",
"name": "isoenzyme",
"pos": [
72,
81
]
} | {
"id": "C0014442",
"name": "enzymes",
"pos": [
97,
104
]
} |
in vitro vascular responses were determined for acetylcholine , acepromazine , isoxsuprine hydrochloride ( isoxsuprine ) , prostaglandin e2 ( pge2 ) , and prostaglandin i2 ( prostacyclin ) . | NA | {
"id": "C0282213",
"name": "isoxsuprine hydrochloride",
"pos": [
79,
104
]
} | {
"id": "C0022267",
"name": "isoxsuprine",
"pos": [
107,
118
]
} |
heart rate , respiratory frequency , indirect blood pressure , rectal temperature , toe web temperature , and plasma concentrations of epinephrine and norepinephrine were determined before induction of anesthesia , after intubation , after extubation , at sternal recumbency , and at standing . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
135,
146
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
151,
165
]
} |
after anesthesia , 15 % of the epinephrine and 12 % of the norepinephrine samples were more than two standard deviations above the mean of the preanesthetic concentrations of all dogs . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
31,
42
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
59,
73
]
} |
activation of protein kinase c by a phorbol ester , 12-o-tetradecanoylphorbol-13-acetate ( tpa ) , was shown to stimulate the respiratory burst in normal cat neutrophils . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
36,
49
]
} | {
"id": "C0039654",
"name": "12-o-tetradecanoylphorbol-13-acetate",
"pos": [
52,
88
]
} |
since the observed tissue : plasma concentration was higher and a therapeutic concentration was maintained in interstitial fluid and milk for longer , the drug can be used for other systemic infections at a lower dose rate than that required for treating septicaemia . | NA | {
"id": "C0243026",
"name": "systemic infections",
"pos": [
182,
201
]
} | {
"id": "C0036690",
"name": "septicaemia",
"pos": [
255,
266
]
} |
the total number of agnor per nucleus in epithelioid and spindle cell leiomyosarcomas significantly ( p less than 0.001 ) exceeded that in leiomyomas , cellular leiomyomas and epithelioid leiomyoblastomas . | NA | {
"id": "C0023267",
"name": "leiomyomas",
"pos": [
139,
149
]
} | {
"id": "C0086533",
"name": "leiomyoblastomas",
"pos": [
188,
204
]
} |
lung injury induced in rats by the pyrrolizidine alkaloid monocrotaline is a well-documented model of pulmonary hypertension . | NA | {
"id": "C0034335",
"name": "pyrrolizidine alkaloid",
"pos": [
35,
57
]
} | {
"id": "C0085241",
"name": "monocrotaline",
"pos": [
58,
71
]
} |
unlike previous studies in rats , however , monocrotaline-treated mice developed relatively little lung fibrosis , cardiomegaly , or right ventricular hypertrophy , and no occlusive medial thickening of the pulmonary arteries , even at the highest dose level . | NA | {
"id": "C0018800",
"name": "cardiomegaly",
"pos": [
115,
127
]
} | {
"id": "C0162770",
"name": "right ventricular",
"pos": [
133,
150
]
} |
two-dimensional electrophoresis of gag extracted from the cells demonstrated that hsgc-e1 contained a much greater amount of heparan sulfate ( hs , 53.5 % of total ) , while hsgc synthesized hyaluronic acid ( ha , 17.5 % ) , hs 38.8 % , chondroitin sulfate ( ch-s , 27.6 % ) and dermatan sulfate ( ds , 16.1 % ) . | NA | {
"id": "C0017973",
"name": "gag",
"pos": [
35,
38
]
} | {
"id": "C0019143",
"name": "heparan sulfate",
"pos": [
125,
140
]
} |
in some pleomorphic adenomas , carcinomas in pleomorphic adenomas , one mucoepidermoid carcinoma , one mucus-producing adenopapillary carcinoma and one adenoid cystic carcinoma , cells expressing three different ifp classes were found ( cks , vimentin , gfap ) . | NA | {
"id": "C0021769",
"name": "ifp",
"pos": [
212,
215
]
} | {
"id": "C0042666",
"name": "vimentin",
"pos": [
243,
251
]
} |
in some pleomorphic adenomas , carcinomas in pleomorphic adenomas , one mucoepidermoid carcinoma , one mucus-producing adenopapillary carcinoma and one adenoid cystic carcinoma , cells expressing three different ifp classes were found ( cks , vimentin , gfap ) . | NA | {
"id": "C0021769",
"name": "ifp",
"pos": [
212,
215
]
} | {
"id": "C0017626",
"name": "gfap",
"pos": [
254,
258
]
} |
the transposable ifp2 element of trichoplusia ni was originally isolated as a host dna insertion in spontaneous fp mutants of galleria mellonella or autographa californica nuclear polyhedrosis viruses ( npvs ) . | NA | {
"id": "C0012868",
"name": "transposable",
"pos": [
4,
16
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
83,
86
]
} |
therefore , ha of fixed chicken erythrocytes by trypsin-untreated human and animal rotaviruses may be independent of sialic acids , whereas that of fresh erythrocytes by sa-11 and ncdv is sialic acid dependent and probably mediated by glycophorin a . | NA | {
"id": "C0037025",
"name": "sialic",
"pos": [
117,
123
]
} | {
"id": "C0067762",
"name": "sialic acid",
"pos": [
188,
199
]
} |
while only the central core of the encoded 94-kda ccmv 2a protein contains features conserved among known and putative rna replication proteins from many viruses , both flanking regions of ccmv 2a show substantial similarity to the corresponding protein of the related brome mosaic virus ( bmv ) . | NA | {
"id": "C0042736",
"name": "proteins",
"pos": [
135,
143
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
246,
253
]
} |
at the same time , distinct dissimilarity of the patterns studied was found between healthy donors and patients with chronic alcoholism when concentration ratios of some positively and negatively charged acute phase proteins were calculated ( alpha 1-antitrypsin/albumin , haptoglobin/albumin , haptoglobin/transferrin )... | NA | {
"id": "C0001347",
"name": "acute phase proteins",
"pos": [
204,
224
]
} | {
"id": "C0002191",
"name": "alpha 1-antitrypsin",
"pos": [
243,
262
]
} |
at the same time , distinct dissimilarity of the patterns studied was found between healthy donors and patients with chronic alcoholism when concentration ratios of some positively and negatively charged acute phase proteins were calculated ( alpha 1-antitrypsin/albumin , haptoglobin/albumin , haptoglobin/transferrin )... | NA | {
"id": "C0001347",
"name": "acute phase proteins",
"pos": [
204,
224
]
} | {
"id": "C0018595",
"name": "haptoglobin",
"pos": [
295,
306
]
} |
at the same time , distinct dissimilarity of the patterns studied was found between healthy donors and patients with chronic alcoholism when concentration ratios of some positively and negatively charged acute phase proteins were calculated ( alpha 1-antitrypsin/albumin , haptoglobin/albumin , haptoglobin/transferrin )... | NA | {
"id": "C0001347",
"name": "acute phase proteins",
"pos": [
204,
224
]
} | {
"id": "C0040679",
"name": "transferrin",
"pos": [
307,
318
]
} |
clinical , electroroentgenographic and x-ray studies of soft tissues were carried out in 425 patients with malignant ( 75 ) , benign ( 246 ) soft tissue tumors and in cases of such soft tissue pathologies of the extremities and body ( 104 ) as bursitis , hematoma , cyst and ganglia which may clinically simulate tumors ... | NA | {
"id": "C0010709",
"name": "cyst",
"pos": [
266,
270
]
} | {
"id": "C0027651",
"name": "tumors",
"pos": [
313,
319
]
} |
during early reconvalescence the majority of patients revealed functional changes of the biliary tract , mainly , in the form of hypotensive-hypokinetic type of dyskinesia . | NA | {
"id": "C0086439",
"name": "hypokinetic",
"pos": [
141,
152
]
} | {
"id": "C0013384",
"name": "dyskinesia",
"pos": [
161,
171
]
} |
the reference ranges of some of the most frequently used in the clinical laboratory practice serum enzymes and isoenzymes are determined : aspartate aminotransferase ( asat ) , alanine aminotransferase ( alat ) , creatine kinase ( ck ) and its isoenzyme ( ck-mb ) , lactate dehydrogenase ( ldh ) and its isoenzyme -- hbd... | NA | {
"id": "C0014442",
"name": "enzymes",
"pos": [
99,
106
]
} | {
"id": "C0022173",
"name": "isoenzyme",
"pos": [
304,
313
]
} |
the reference ranges of the enzymes and isoenzymes studied are calculated from the results obtained in 182 clinically healthy persons , 20-50 years of age , by the `` '' single test '' '' method . | NA | {
"id": "C0014442",
"name": "enzymes",
"pos": [
28,
35
]
} | {
"id": "C0022173",
"name": "isoenzymes",
"pos": [
40,
50
]
} |
the age of the patients does not exert any influence on the enzymes and isoenzymes studied . | NA | {
"id": "C0014442",
"name": "enzymes",
"pos": [
60,
67
]
} | {
"id": "C0022173",
"name": "isoenzymes",
"pos": [
72,
82
]
} |
the statistical processing of the results for the determination of the reference ranges of the enzymes and isoenzymes studied is accomplished with a computer `` '' hewlett packard 85 '' '' . | NA | {
"id": "C0014442",
"name": "enzymes",
"pos": [
95,
102
]
} | {
"id": "C0022173",
"name": "isoenzymes",
"pos": [
107,
117
]
} |
small cell lung cancers are neuroendocrine tumours and therefore produce a lot of peptide hormones ( calcitonin , acth , adh ) , as well as the neuropeptide chromogranin a , which are all useful tumour markers . | NA | {
"id": "C0006668",
"name": "calcitonin",
"pos": [
101,
111
]
} | {
"id": "C0027895",
"name": "neuropeptide",
"pos": [
144,
156
]
} |
the rapid spread of hiv infection among intravenous drug abusers plays an increasing role in the aids epidemic . | NA | {
"id": "C0019693",
"name": "hiv infection",
"pos": [
20,
33
]
} | {
"id": "C0001175",
"name": "aids",
"pos": [
97,
101
]
} |
furthermore , since we have found that cns infection is achieved following systemic infection in the guinea pig , the model recapitulates the sequence of infection in humans . | NA | {
"id": "C0243026",
"name": "systemic infection",
"pos": [
75,
93
]
} | {
"id": "C0009450",
"name": "infection",
"pos": [
154,
163
]
} |
uncontrolled studies have shown that patients with acute pancreatitis are not more endangered by ept than those without pancreatitis and that the intervention seems to beneficially influence the course of the pancreatic disease . | NA | {
"id": "C0030305",
"name": "pancreatitis",
"pos": [
57,
69
]
} | {
"id": "C0030286",
"name": "the",
"pos": [
205,
208
]
} |
inflammatory bowel diseases ( ibd ) as crohn 's disease ( cd ) and ulcerative colitis ( uc ) are believed to have a genetic basis . | NA | {
"id": "C0021390",
"name": "inflammatory bowel diseases",
"pos": [
0,
27
]
} | {
"id": "C0010346",
"name": "crohn 's disease",
"pos": [
39,
55
]
} |
we studied seven patients with prinzmetal 's angina and three patients with unstable angina pectoris type iii ( according to the criteria of conti ) during and after a spontaneous attack of angina pectoris by two-dimensional echocardiography . | NA | {
"id": "C0002963",
"name": "prinzmetal 's angina",
"pos": [
31,
51
]
} | {
"id": "C0002965",
"name": "unstable angina pectoris",
"pos": [
76,
100
]
} |
thus , two-dimensional echocardiography performed during an attack of angina pectoris in patients with prinzmetal 's angina and unstable angina pectoris type iii can evaluate the localization , as well as the extent of transient myocardial wall motion abnormalities . | NA | {
"id": "C0002963",
"name": "prinzmetal 's angina",
"pos": [
103,
123
]
} | {
"id": "C0002965",
"name": "unstable",
"pos": [
128,
136
]
} |
the purpose of the present study was to determine whether an antihypertensive treatment with the dihydropyridine nitrendipine can induce regression of severe hypertensive hypertrophy and , whether alterations in systolic and diastolic ventricular function do occur . | NA | {
"id": "C0012315",
"name": "dihydropyridine",
"pos": [
97,
112
]
} | {
"id": "C0028127",
"name": "nitrendipine",
"pos": [
113,
125
]
} |
the adaptation of 4 manual methods to the flow-injection analysis is described for the determination of proteins ( biuret- and exton-method , albumin and hemoglobin determination ) . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
104,
112
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
142,
149
]
} |
in addition , yersiniosis-associated arthritis concurs with the signs and symptoms of systemic disease -- gastroenterocolitis , myocardiopathy and myocarditis , erythema nodosum , hepatitis , urethritis , conjunctivitis , myositis and myalgia , enteropathy ; | NA | {
"id": "C0878544",
"name": "myocardiopathy",
"pos": [
128,
142
]
} | {
"id": "C0027059",
"name": "myocarditis",
"pos": [
147,
158
]
} |
considerable difference between the detectability of mycoplasma antigens and antibodies can be attributed to the fact that the bulk of the antigens form part of immune complexes and can not be detected by serologic tests . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
77,
87
]
} | {
"id": "C0003313",
"name": "immune complexes",
"pos": [
161,
177
]
} |
azelaic acid cream was significantly and substantially more effective than its vehicle , indicating that the dicarboxylic acid itself is an active drug in acne treatment . | NA | {
"id": "C0052761",
"name": "azelaic acid",
"pos": [
0,
12
]
} | {
"id": "C0012063",
"name": "dicarboxylic acid",
"pos": [
109,
126
]
} |
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