text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
in order to elucidate the mechanism ( s ) underlying this inhibitory effect , i elected to study the effects of aza and , for control purposes , adipic acid ( ada ) on dna synthesis rate of nuclei isolated from melanoma cells and keratinocytes cultured in the presence of different concentrations of the dicarboxylic aci... | NA | {
"id": "C0052761",
"name": "aza",
"pos": [
112,
115
]
} | {
"id": "C0012063",
"name": "dicarboxylic acids",
"pos": [
304,
322
]
} |
these data suggest that the inhibitory effect of the dicarboxylic acids aza and ada on dna synthesis of several cell lines is due to the interference of these substances with the activation of enzymes ( e.g . dna polymerases ) required for dna synthesis . | NA | {
"id": "C0012063",
"name": "dicarboxylic acids",
"pos": [
53,
71
]
} | {
"id": "C0052761",
"name": "aza",
"pos": [
72,
75
]
} |
among da , azelaic acid ( aa , c9 dicarboxylic acid ) is extensively used because : 1 ) it is much cheaper than other da ; | NA | {
"id": "C0052761",
"name": "azelaic acid",
"pos": [
11,
23
]
} | {
"id": "C0012063",
"name": "da",
"pos": [
118,
120
]
} |
by contrast , levels of 17-oh-progesterone ( 30 nmol/l ) and progesterone ( 2.45 nmol/l ) increased slightly , indicating inhibition of adrenal 17,20-lyase . | NA | {
"id": "C0020387",
"name": "17-oh-progesterone",
"pos": [
24,
42
]
} | {
"id": "C0033308",
"name": "progesterone",
"pos": [
61,
73
]
} |
the avian amyloid cross-reacted with a number of monoclonal and polyclonal anti-aa antibodies directed against mammalian amyloid fibril proteins . | NA | {
"id": "C0002716",
"name": "amyloid",
"pos": [
10,
17
]
} | {
"id": "C1456454",
"name": "amyloid",
"pos": [
121,
128
]
} |
hydrocortisone-acetate ( hc ) or dexamethasone ( dex ) were administered to the animals starting 1 , 2 , 3 , 4 , or 5 d before killing , at the doses of 25 micrograms or 1 microgram/ ( g b. w. x d ) , respectively . | NA | {
"id": "C0063077",
"name": "hydrocortisone-acetate",
"pos": [
0,
22
]
} | {
"id": "C0020268",
"name": "hc",
"pos": [
25,
27
]
} |
the water soluble benzodiazepine derivative , midazolam , is used almost exclusively at our institution to produce sedation for numerous surgical procedures . | NA | {
"id": "C0005064",
"name": "benzodiazepine",
"pos": [
18,
32
]
} | {
"id": "C0026056",
"name": "midazolam",
"pos": [
46,
55
]
} |
in addition to widespread silicone oil endothelial contact in 2 eyes , a bubble or droplets of silicone oil were observed in the anterior chamber in 8 eyes . | NA | {
"id": "C0037111",
"name": "silicone oil",
"pos": [
26,
38
]
} | {
"id": "C0037114",
"name": "silicone",
"pos": [
95,
103
]
} |
by reducing plasma ph ( hypercapnia at high plasma bicarbonate concentration ) , the slope of the gtb curves for nacl and nahco3 can be greatly increased . | NA | {
"id": "C0005367",
"name": "bicarbonate",
"pos": [
51,
62
]
} | {
"id": "C0074722",
"name": "nahco3",
"pos": [
122,
128
]
} |
by raising plasma ph either by hypocapnia or bicarbonate loading , proximal reabsorption of nahco3 and nacl is greatly depressed and remains almost unaltered during variations of gfr ( abolished gtb ) . | NA | {
"id": "C0005367",
"name": "bicarbonate",
"pos": [
45,
56
]
} | {
"id": "C0074722",
"name": "nahco3",
"pos": [
92,
98
]
} |
the antihypoxic effect of the newly-synthesized hydroxylamine barbiturate hb-7 , compared with the effects of phenobarbital and pentobarbital , was studied in experiments on albino mice , using the following models of hypoxia : hypobaric , anoxic , asphyctic and haemic . | NA | {
"id": "C0004745",
"name": "barbiturate",
"pos": [
62,
73
]
} | {
"id": "C0030883",
"name": "pentobarbital",
"pos": [
128,
141
]
} |
the pulmonary concentration of paraquat seems to be due to a mechanism of active concentration , which seems to be used by polyamines and diamines in normal situations . | NA | {
"id": "C0032433",
"name": "polyamines",
"pos": [
123,
133
]
} | {
"id": "C0011957",
"name": "diamines",
"pos": [
138,
146
]
} |
most of them were glioblastomas ( n = 43 ; 27 % ) and astrocytic tumours ( n = 81 ; 50.9 % ) . | NA | {
"id": "C0017636",
"name": "glioblastomas",
"pos": [
18,
31
]
} | {
"id": "C0004114",
"name": "astrocytic tumours",
"pos": [
54,
72
]
} |
early clinical studies with combined cephaloridine and aminoglycoside therapy suggested that a synergistic nephrotoxic interaction was possible between agents in these two classes of antimicrobial drugs . | NA | {
"id": "C0002556",
"name": "aminoglycoside",
"pos": [
55,
69
]
} | {
"id": "C1136254",
"name": "antimicrobial drugs",
"pos": [
183,
202
]
} |
the development of newer antimicrobial drugs with broader microbial coverage and a lesser nephrotoxic potential than agents currently in use may reduce the need for combining cephalosporins and aminoglycoside or provide safer drug combinations for many clinical situations . | NA | {
"id": "C1136254",
"name": "antimicrobial",
"pos": [
25,
38
]
} | {
"id": "C0002556",
"name": "aminoglycoside",
"pos": [
194,
208
]
} |
incubation with phase ii monoclonal antibodies or inactivated immune sera containing phase i and phase ii antibodies or phase ii antibodies only , markedly reduced phase ii c. burnetii red plaques . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
25,
46
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
129,
139
]
} |
incubation with phase ii monoclonal antibodies or inactivated immune sera containing phase i and phase ii antibodies or phase ii antibodies only , markedly reduced phase ii c. burnetii red plaques . | NA | {
"id": "C0020960",
"name": "immune sera",
"pos": [
62,
73
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
129,
139
]
} |
on the other hand , red plaques from phase i organisms increased several times when phase i cells were mixed with phase i monoclonal antibodies or inactivated immune sera containing phase i and phase ii antibodies . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
122,
143
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
203,
213
]
} |
on the other hand , red plaques from phase i organisms increased several times when phase i cells were mixed with phase i monoclonal antibodies or inactivated immune sera containing phase i and phase ii antibodies . | NA | {
"id": "C0020960",
"name": "immune sera",
"pos": [
159,
170
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
203,
213
]
} |
in vivo and in vitro studies were performed to compare ibca with n-butyl 2-cyanoacrylate ( nbca , supplied as histoacryl blue ) , a tissue adhesive approved for surgical use in some countries . | NA | {
"id": "C0006341",
"name": "ibca",
"pos": [
55,
59
]
} | {
"id": "C0014035",
"name": "histoacryl blue",
"pos": [
110,
125
]
} |
[ hla compatibility and susceptibility to habitual abortion . results of histocompatibility testing of couples with frequent miscarriages ] . | NA | {
"id": "C0000809",
"name": "habitual abortion",
"pos": [
42,
59
]
} | {
"id": "C0000786",
"name": "miscarriages",
"pos": [
125,
137
]
} |
although gastroesophageal reflux disease is the most common and easily treated cause of esophageal chest pain , esophageal motility disorders should also be considered . | NA | {
"id": "C0017168",
"name": "gastroesophageal reflux",
"pos": [
9,
32
]
} | {
"id": "C0014858",
"name": "esophageal motility disorders",
"pos": [
112,
141
]
} |
we then examined the effects of mgcl2 , ttx , and verapamil on depolarization-induced automaticity by means of a single sucrose gap technique to gain insight into the mechanism of action of magnesium . | NA | {
"id": "C0024472",
"name": "mgcl2",
"pos": [
32,
37
]
} | {
"id": "C0024467",
"name": "magnesium",
"pos": [
190,
199
]
} |
there were no significant effects on the plasma concentrations of norepinephrine , epinephrine , aldosterone , vasopressin , cortisol , growth hormone , or prolactin and no significant change in plasma renin activity . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
66,
80
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
83,
94
]
} |
it is concluded that thallium perfusion abnormalities are common in patients with hc in the absence of epicardial coronary disease , and are strongly associated with potentially lethal arrhythmias . | NA | {
"id": "C0018799",
"name": "the",
"pos": [
88,
91
]
} | {
"id": "C0003811",
"name": "arrhythmias",
"pos": [
185,
196
]
} |
morphologic methods have been employed for the screening and selection of monoclonal antibodies reactive with the surface of human ovarian cancer cells for use as immunotoxins and have demonstrated the in vivo activity of immunotoxins made with these antibodies and pseudomonas exotoxin in a nude mouse model system . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
74,
95
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
251,
261
]
} |
since insulin and c-peptide form the proinsulin chain , their antigenic sites were found in the same locations along the secretory pathway ; | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
6,
13
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
37,
47
]
} |
since insulin and c-peptide form the proinsulin chain , their antigenic sites were found in the same locations along the secretory pathway ; | NA | {
"id": "C0006558",
"name": "c-peptide",
"pos": [
18,
27
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
37,
47
]
} |
however , upon dissociation of proinsulin into insulin and c-peptide , both antigenic sites are segregated in different locations . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
31,
41
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
47,
54
]
} |
however , upon dissociation of proinsulin into insulin and c-peptide , both antigenic sites are segregated in different locations . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
31,
41
]
} | {
"id": "C0006558",
"name": "c-peptide",
"pos": [
59,
68
]
} |
in the first set of studies , immunogold labels for adrenocorticotropin ( acth ) or luteinizing hormone ( lh beta ) and follicle-stimulating hormone ( fsh beta ) were applied to ultrathin sections of pituitaries from adrenalectomized rats or from rats in different stages of the estrous cycle . | NA | {
"id": "C0023607",
"name": "luteinizing",
"pos": [
84,
95
]
} | {
"id": "C0065261",
"name": "lh beta",
"pos": [
106,
113
]
} |
in the first set of studies , immunogold labels for adrenocorticotropin ( acth ) or luteinizing hormone ( lh beta ) and follicle-stimulating hormone ( fsh beta ) were applied to ultrathin sections of pituitaries from adrenalectomized rats or from rats in different stages of the estrous cycle . | NA | {
"id": "C0733758",
"name": "follicle-stimulating hormone",
"pos": [
120,
148
]
} | {
"id": "C3266859",
"name": "fsh beta",
"pos": [
151,
159
]
} |
the question of whether these double-labeled cells represent different cell populations , transitional cell types , or precursor cells requires further investigation . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
45,
50
]
} | {
"id": "C0018956",
"name": "precursor cells",
"pos": [
119,
134
]
} |
there were no significant elevations in the mean plasma concentrations of cholesterol , low-density-lipoprotein cholesterol , or apolipoprotein b . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
74,
85
]
} | {
"id": "C0023824",
"name": "low-density-lipoprotein",
"pos": [
88,
111
]
} |
the effect of iron supplementation on attending behavior of 96 1-y-old infants was assessed in a double-blind , randomized , controlled trial of iron dextran in papua new guinea . | NA | {
"id": "C0302583",
"name": "iron",
"pos": [
14,
18
]
} | {
"id": "C0022092",
"name": "iron dextran",
"pos": [
145,
157
]
} |
seventy-two children ( age range , 3 months to 5.5 years ) with a clinical diagnosis of obstructive bronchitis ( asthmatoid or spastic bronchitis or bronchiolitis ) were found to have bronchial casts in the gastric fluid , and in 2 additional cases casts were spontaneously expectorated in the bronchial exudate . | NA | {
"id": "C0006277",
"name": "bronchitis",
"pos": [
100,
110
]
} | {
"id": "C0006271",
"name": "bronchiolitis",
"pos": [
149,
162
]
} |
we conclude that the high prevalence of this skin lesion further suggests that insulin resistance and hyperinsulinemia , with all of their serious medical implications , are also highly prevalent . | NA | {
"id": "C0021655",
"name": "insulin resistance",
"pos": [
79,
97
]
} | {
"id": "C0020459",
"name": "hyperinsulinemia",
"pos": [
102,
118
]
} |
local intradermal injections of actinomycin d , cycloheximide or puromycin could inhibit in a dose- and time-dependent manner neutrophil emigration induced by interleukin-1 , tumor necrosis factor alpha or endotoxin , but not by the leukocyte chemoattractants c5a des arg ( zymosan-activated plasma ) , n-formyl-methiony... | NA | {
"id": "C0008013",
"name": "chemoattractants",
"pos": [
243,
259
]
} | {
"id": "C0027229",
"name": "n-formyl-methionyl-leucyl-phenylalanine",
"pos": [
303,
342
]
} |
the major il-1 secreted by hdlm-1 cells was il-1 alpha , and by km-h2 cells was il-1 beta . | NA | {
"id": "C0021755",
"name": "il-1",
"pos": [
10,
14
]
} | {
"id": "C0600251",
"name": "il-1 alpha",
"pos": [
44,
54
]
} |
non-neoplastic mammary gland , 20 benign tumors and 206 carcinomas of the breast were immunohistochemically examined for expression of hla-a , -b , -c , hla-dr , -dp , and -dq molecules and the hla-d associated invariant chain ( ii ) . | NA | {
"id": "C0019764",
"name": "hla-dr",
"pos": [
153,
159
]
} | {
"id": "C0019754",
"name": "hla-d",
"pos": [
194,
199
]
} |
associated with lymphohistiocytic stromal infiltrates , hla-d/ii determinants were found to be induced in benign duct and acinar epithelium after the order ii greater than or equal to hla-dr greater than or equal to hla-dp greater than or equal to hla-dq . | NA | {
"id": "C0019754",
"name": "hla-d",
"pos": [
56,
61
]
} | {
"id": "C0019764",
"name": "hla-dr",
"pos": [
184,
190
]
} |
associated with lymphohistiocytic stromal infiltrates , hla-d/ii determinants were found to be induced in benign duct and acinar epithelium after the order ii greater than or equal to hla-dr greater than or equal to hla-dp greater than or equal to hla-dq . | NA | {
"id": "C0019754",
"name": "hla-d",
"pos": [
56,
61
]
} | {
"id": "C0019759",
"name": "hla-dp",
"pos": [
216,
222
]
} |
the macromolecule containing the epitope recognized by this antibody was purified from serum of whhl rabbits , antigenic material similar to that found in serum and atherosclerotic plaques . | NA | {
"id": "C0003316",
"name": "epitope",
"pos": [
33,
40
]
} | {
"id": "C0003320",
"name": "antigenic",
"pos": [
111,
120
]
} |
it contained 22.2 mg of sugar per 100 mg protein , and sialic acid at least expressed the activity of the epitope because the antigenic activity was decreased by neuraminidase treatment . | NA | {
"id": "C0003316",
"name": "epitope",
"pos": [
106,
113
]
} | {
"id": "C0003320",
"name": "antigenic",
"pos": [
126,
135
]
} |
severity appeared to correlate with the level of maternal and placental parasitemias , regardless of infant birth weight or placental weight . | NA | {
"id": "C0005612",
"name": "infant birth weight",
"pos": [
101,
120
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
134,
140
]
} |
nonsurgical alternative therapies for gallstone disease are unlikely to decrease the mortality from calculous biliary tract disease . | NA | {
"id": "C0008350",
"name": "gallstone disease",
"pos": [
38,
55
]
} | {
"id": "C0005424",
"name": "biliary tract disease",
"pos": [
110,
131
]
} |
they appear to ensure patient safety , but the actual conditions that predict successful treatment of gallstones by eswl are not yet known , since the clinical and in vitro studies which will define the patient and stone characteristics that predict a successful treatment outcome are still in progress . | NA | {
"id": "C0008350",
"name": "gallstones",
"pos": [
102,
112
]
} | {
"id": "C0006736",
"name": "stone",
"pos": [
215,
220
]
} |
gallstone fragmentation occurred in 95 percent of all patients and in 97 percent of those patients with solitary stones under 20 mm in size . | NA | {
"id": "C0008350",
"name": "gallstone",
"pos": [
0,
9
]
} | {
"id": "C0006736",
"name": "stones",
"pos": [
113,
119
]
} |
bile must be supersaturated in cholesterol for gallstones to form , and desaturation of bile by orally administered bile acids induces gradual stone dissolution . | NA | {
"id": "C0008350",
"name": "gallstones",
"pos": [
47,
57
]
} | {
"id": "C0006736",
"name": "stone",
"pos": [
143,
148
]
} |
oral bile acids may also be valuable in the treatment of gallstone recurrence before it has become symptomatic or to prevent recurrence after prior successful dissolution of recurrent stones . | NA | {
"id": "C0008350",
"name": "gallstone",
"pos": [
57,
66
]
} | {
"id": "C0006736",
"name": "stones",
"pos": [
184,
190
]
} |
it was found that the infection was more frequent in females aged under 30 years , in those who was born preterm , in patients with early ( premarital ) sexual contacts or those with spontaneously stopped pregnancy during the first trimester , as well as in those females who suffered from cervicitis , yeast colpitis , ... | NA | {
"id": "C0032961",
"name": "pregnancy",
"pos": [
205,
214
]
} | {
"id": "C0032979",
"name": "first trimester",
"pos": [
226,
241
]
} |
in those patients whose pregnancy was lost in the first trimester and the cause of the wastage remained unclear , the authors noted elevated t and decreased b lymphocytes , as well as dramatically reduced leukocyte migration inhibition factor . | NA | {
"id": "C0032961",
"name": "pregnancy",
"pos": [
24,
33
]
} | {
"id": "C0032979",
"name": "first trimester",
"pos": [
50,
65
]
} |
three of them worked in a hospital three showed immediate hypersensitivity to fruit and all had known urticaria to latex . | NA | {
"id": "C0020523",
"name": "immediate",
"pos": [
48,
57
]
} | {
"id": "C0042109",
"name": "urticaria",
"pos": [
102,
111
]
} |
[ fentanyl versus sufentanil basic anesthesia . hypnotic effect , muscle rigidity and efficacy of competitive muscle relaxants ] . | NA | {
"id": "C0015846",
"name": "fentanyl",
"pos": [
2,
10
]
} | {
"id": "C0143993",
"name": "sufentanil",
"pos": [
18,
28
]
} |
as induction agents for cardioanesthesia , sufentanil ( s ) and fentanyl ( f ) are usually employed in combination with nondepolarizing muscle relaxants . | NA | {
"id": "C0143993",
"name": "sufentanil",
"pos": [
43,
53
]
} | {
"id": "C0015846",
"name": "fentanyl",
"pos": [
64,
72
]
} |
detection of 0.1 to 200 pmol glutathione produces a linear response and the recovery of reduced and oxidized glutathione from rat liver homogenate , bile , and plasma is quantitative . | NA | {
"id": "C0017817",
"name": "glutathione",
"pos": [
29,
40
]
} | {
"id": "C0061516",
"name": "oxidized glutathione",
"pos": [
100,
120
]
} |
other compounds which were unaffected by bsa included coa , free beta-keto acid , beta-hydroxyacyl coa , acyl coa , trans-2-enoyl coa , and malonyl coa . | NA | {
"id": "C0001374",
"name": "acyl coa",
"pos": [
94,
102
]
} | {
"id": "C0024645",
"name": "malonyl coa",
"pos": [
140,
151
]
} |
after conversion of the carboxylic acids to their pentafluorobenzyl esters the extract is purified by straight-phase hplc . | NA | {
"id": "C0007066",
"name": "carboxylic acids",
"pos": [
24,
40
]
} | {
"id": "C0014898",
"name": "esters",
"pos": [
68,
74
]
} |
methyl esters formed by methylation of carboxylic acid groups on hemoglobin can be quantitated via gc/ms negative-ion chemical ionization analysis of the pentafluorobenzoate derivative of the methanol released from the hemoglobin upon base hydrolysis . | NA | {
"id": "C0014898",
"name": "esters",
"pos": [
7,
13
]
} | {
"id": "C0007066",
"name": "carboxylic acid",
"pos": [
39,
54
]
} |
in addition , chondroitin sulfates and heparan sulfate are identified either by prior digestion with chondroitin abc or ac lyase , as generated disaccharides fail to bind to the blot , or by treatment of the entire blot with nitrous acid following binding . | NA | {
"id": "C0008466",
"name": "chondroitin sulfates",
"pos": [
14,
34
]
} | {
"id": "C0008454",
"name": "chondroitin",
"pos": [
101,
112
]
} |
the assay is based on a sequential sandwich immunobioassay that uses a microtiter plate coated with anti-ril-2 monoclonal antibody ( specific for recombinant human il-2 ) to capture ril-2 from serum , and an il-2 dependent t-cell line that proliferates in a dose-dependent fashion . | NA | {
"id": "C0218986",
"name": "recombinant human il-2",
"pos": [
146,
168
]
} | {
"id": "C0021756",
"name": "il-2",
"pos": [
208,
212
]
} |
6 ) the released procollagen is transformed into collagen before or , more probably , after associating with the surface of a collagen fibril . | NA | {
"id": "C0033235",
"name": "procollagen",
"pos": [
17,
28
]
} | {
"id": "C0009325",
"name": "collagen",
"pos": [
126,
134
]
} |
the noncollagenous proteins ( ncps ) , which constitute about 10 % of the matrix , fall into several categories : phosphoproteins , gla-proteins of the osteocalcin type as well as matrix gla-protein , proteoglycans , different acidic glycoproteins , and serum proteins . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
19,
27
]
} | {
"id": "C0031689",
"name": "phosphoproteins",
"pos": [
114,
129
]
} |
new data show that polyanionic ncps , such as phosphoprotein and proteoglycans , when immobilized on a solid support , induce apatite formation under physiological conditions . | NA | {
"id": "C0033684",
"name": "ncps",
"pos": [
31,
35
]
} | {
"id": "C0031689",
"name": "phosphoprotein",
"pos": [
46,
60
]
} |
immunocytochemistry with an antibody to mouse amelogenins revealed the presence of eps in the protein synthetic and secretory organelles of these cells at all three stages . | NA | {
"id": "C0051560",
"name": "amelogenins",
"pos": [
46,
57
]
} | {
"id": "C0011353",
"name": "eps",
"pos": [
83,
86
]
} |
immunocytochemistry with an antibody to mouse amelogenins revealed the presence of eps in the protein synthetic and secretory organelles of these cells at all three stages . | NA | {
"id": "C0011353",
"name": "eps",
"pos": [
83,
86
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
94,
101
]
} |
in vitro studies revealed that the rate and degree of breakdown of enamel proteins varied markedly , depending on the stage of amelogenesis from which the proteins were extracted . | NA | {
"id": "C0011353",
"name": "enamel proteins",
"pos": [
67,
82
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
155,
163
]
} |
these receptors bind to an enzyme-linked mannose-6-phosphate recognition marker in the golgi complex , and the enzyme-ligand-receptor complex , carried within small coated transport vesicles , dissociates upon reaching the low ph established in the bone-resorbing compartment by the osteoclast . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
27,
33
]
} | {
"id": "C0026741",
"name": "enzyme",
"pos": [
111,
117
]
} |
the distribution of motoneurons innervating the primary depressor and elevator muscles of the wing of the domestic pigeon ( columba livia ) was studied by using the retrograde axonal tracer lectin-conjugated horseradish peroxidase ( wga-hrp ) . | NA | {
"id": "C0019941",
"name": "horseradish peroxidase",
"pos": [
208,
230
]
} | {
"id": "C0078473",
"name": "wga-hrp",
"pos": [
233,
240
]
} |
semen quality related correlations could not be found for the dipeptidyl aminopeptidase ( dpiv ) and the aminopeptidase a ( apa ) . | NA | {
"id": "C0002570",
"name": "aminopeptidase",
"pos": [
73,
87
]
} | {
"id": "C0052527",
"name": "aminopeptidase a",
"pos": [
105,
121
]
} |
men who lived in the vicinity of an atmospheric source of heavy metals showed strikingly the vicinity of an atmospheric source of heavy metals showed strikingly elevated levels of semen lead and cadmium . | NA | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
58,
70
]
} | {
"id": "C0006632",
"name": "cadmium",
"pos": [
195,
202
]
} |
arterial blood lactate , arterial glucose , hemodynamic variables , insulin , glucagon , cortisol , epinephrine , and norepinephrine were determined preoperatively and intraoperatively . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
100,
111
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
118,
132
]
} |
there were no significant changes in hemodynamic values , glucagon , norepinephrine , and epinephrine compared with control values in both groups . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
69,
83
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
90,
101
]
} |
the high molecular fraction b1 was most allergenic ( 100 % ) and contained three antigens of high molecular weight . | NA | {
"id": "C0002092",
"name": "allergenic",
"pos": [
40,
50
]
} | {
"id": "C0003320",
"name": "antigens",
"pos": [
81,
89
]
} |
total protein profiles of all isolates were compared by coomassie brilliant blue staining of t foetus protein samples prepared by 4 protein-extraction methods . | NA | {
"id": "C0015950",
"name": "foetus protein",
"pos": [
95,
109
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
132,
139
]
} |
results of data syntheses : approaches include using antibody alone ( interacting with complement or effector cells or binding directly with certain cell receptors ) and immunoconjugates ( antibody coupled to radioisotopes , drugs , toxins , or other biologicals ) . | NA | {
"id": "C0243020",
"name": "immunoconjugates",
"pos": [
170,
186
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
189,
197
]
} |
although the immunoconjugates are very promising , heterogeneity and the antimouse immune response have hampered this approach as has the additional challenge of chemically or genetically coupling antibody to cytotoxic agents . | NA | {
"id": "C0243020",
"name": "immunoconjugates",
"pos": [
13,
29
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
197,
205
]
} |
comparison of cp-2 and transferrin synthesis by immature ( 17-day ) and mature ( 75-day ) sertoli cells within intact seminiferous tubules has documented a significant increase in the synthesis of both proteins during testicular maturation . | NA | {
"id": "C0033684",
"name": "cp-2",
"pos": [
14,
18
]
} | {
"id": "C0034861",
"name": "synthesis",
"pos": [
184,
193
]
} |
these data in conjunction with previous comparisons of the stage-specific changes in cp-2 and transferrin synthesis and secretion led to the hypothesis that the synthesis of these two proteins is regulated by different cellular interactions . | NA | {
"id": "C0033684",
"name": "cp-2",
"pos": [
85,
89
]
} | {
"id": "C0034861",
"name": "synthesis",
"pos": [
161,
170
]
} |
fifty-three of 57 patients who had evidence of bitemporal epileptiform abnormalities and who required investigation with stereotactic depth electroencephalography ( sdeeg ) recordings to determine the site of origin of seizures underwent surgical resection for the treatment of their epilepsy . | NA | {
"id": "C0036572",
"name": "seizures",
"pos": [
219,
227
]
} | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
284,
292
]
} |
dopamine receptor up-regulation in the denervated striatum relative to the intact striatum was statistically significant for d1 but not d2 receptors : this asymmetry in dopamine receptor levels was diminished following intermittent levodopa treatment . | NA | {
"id": "C0058698",
"name": "d2 receptors",
"pos": [
136,
148
]
} | {
"id": "C0034798",
"name": "dopamine receptor",
"pos": [
169,
186
]
} |
in 2 siblings with autosomal dominant familial long q-t syndrome , electroencephalographic examinations performed 6 and 2 years before diagnosis included electrocardiographic tracings documenting the cardiac abnormality . | NA | {
"id": "C0023976",
"name": "long",
"pos": [
47,
51
]
} | {
"id": "C0018798",
"name": "cardiac",
"pos": [
200,
207
]
} |
none of the patients in this group had had a stroke , and the clinical status at follow-up was not found to correlate with the duration of the visual loss ( amaurosis fugax versus ocular infarction ) , frequency ( single versus recurrent episodes ) , sex , presence of headache or heart disease , cigarette smoking , use... | NA | {
"id": "C0456909",
"name": "visual loss",
"pos": [
143,
154
]
} | {
"id": "C0149793",
"name": "amaurosis fugax",
"pos": [
157,
172
]
} |
we conclude that amaurosis fugax and ocular infarction occurring in the younger patient are probably associated with a more benign clinical course than that seen in older persons and that migraine is a likely cause for the episodes of visual loss in a majority of this group . | NA | {
"id": "C0149793",
"name": "amaurosis fugax",
"pos": [
17,
32
]
} | {
"id": "C0456909",
"name": "visual loss",
"pos": [
235,
246
]
} |
a year-long prospective study revealed that victims of this complication of epilepsy are most commonly black males averaging 35 years of age who have infrequent generalized seizures and usually have some structural lesion in the brain responsible for their seizures . | NA | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
76,
84
]
} | {
"id": "C0036572",
"name": "seizures",
"pos": [
257,
265
]
} |
we prepared rna probes from cloned segments of human and murine enteroviruses ( evs ) for in situ hybridization of skeletal muscle biopsies from patients with dermatomyositis ( dm ) , polymyositis , other inflammatory myopathies , and noninflammatory muscle diseases , and from normal control subjects . | NA | {
"id": "C0027121",
"name": "inflammatory myopathies",
"pos": [
205,
228
]
} | {
"id": "C0026848",
"name": "muscle diseases",
"pos": [
251,
266
]
} |
using [ 32p ] 8n3gtp we demonstrate that the exchangeable gtp site of the beta subunit of tubulin is available to added guanine nucleotide in normal aged brain homogenates , whereas it is variably unavailable in alzheimer 's diseased brain . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
17,
20
]
} | {
"id": "C0018328",
"name": "guanine nucleotide",
"pos": [
120,
138
]
} |
the chromatography procedure separated factor xa from factor x , the russel 's viper venom proteinase used to activate factor x , and traces of contaminating thrombin . alpha-factor xa was unstable at ph 7.6 and 25 degrees c , undergoing slow proteolytic degradation to functionally heterogeneous products as evidenced b... | NA | {
"id": "C0015518",
"name": "factor x",
"pos": [
39,
47
]
} | {
"id": "C0015520",
"name": "factor xa",
"pos": [
175,
184
]
} |
these proteins were glycine-rich , in addition to being cysteine-rich , and lacked methionine , histidine , arginine , and the aromatic amino acids phenylalanine and tyrosine . | NA | {
"id": "C0301713",
"name": "aromatic amino acids",
"pos": [
127,
147
]
} | {
"id": "C0031453",
"name": "phenylalanine",
"pos": [
148,
161
]
} |
these proteins were glycine-rich , in addition to being cysteine-rich , and lacked methionine , histidine , arginine , and the aromatic amino acids phenylalanine and tyrosine . | NA | {
"id": "C0301713",
"name": "aromatic amino acids",
"pos": [
127,
147
]
} | {
"id": "C0041485",
"name": "tyrosine",
"pos": [
166,
174
]
} |
lipoxygenases react with hydroperoxy fatty acids and catalyze dioxygenase or dehydrase ( leukotriene a4 ( lta4 ) synthase ) types of reactions . | NA | {
"id": "C2936592",
"name": "lipoxygenases",
"pos": [
0,
13
]
} | {
"id": "C0599874",
"name": "dioxygenase",
"pos": [
62,
73
]
} |
the enhancement of enzyme activity was not directly related to g protein activation since the effect of gtp gamma s could not be abolished by gdp nor replaced by gtp or guanylyl-imidodiphosphate ( up to 100 microm ) . | NA | {
"id": "C0079469",
"name": "gtp gamma s",
"pos": [
104,
115
]
} | {
"id": "C0018353",
"name": "gtp",
"pos": [
162,
165
]
} |
the enhancement of enzyme activity was not directly related to g protein activation since the effect of gtp gamma s could not be abolished by gdp nor replaced by gtp or guanylyl-imidodiphosphate ( up to 100 microm ) . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
104,
107
]
} | {
"id": "C0018366",
"name": "guanylyl-imidodiphosphate",
"pos": [
169,
194
]
} |
similar results were obtained for l-alanine , l-arginine , l-asparagine , l-aspartic acid , l-cystine , l-glutamic acid , l-glutamine , l-histidine , l-lysine , l-phenylalanine , l-proline , l-serine , and l-tyrosine . | NA | {
"id": "C0061472",
"name": "l-glutamic acid",
"pos": [
104,
119
]
} | {
"id": "C0017797",
"name": "l-glutamine",
"pos": [
122,
133
]
} |
the acetyl-coa-dependent elongation of medium-chain acyl-coa in the presence of pyridine nucleotide was studied in rat liver . | NA | {
"id": "C0001026",
"name": "acetyl-coa",
"pos": [
4,
14
]
} | {
"id": "C0001374",
"name": "coa",
"pos": [
57,
60
]
} |
n-ethylmaleimide ( 0.1 mm ) and oxidized glutathione ( 10 mm ) inhibited gsh-dependent protection but activated microsomal gsh s-transferase activity . | NA | {
"id": "C0061516",
"name": "oxidized glutathione",
"pos": [
32,
52
]
} | {
"id": "C0017817",
"name": "gsh",
"pos": [
123,
126
]
} |
[ effect of uracil on the both reactions , 5-fluorouracil degradation into 2-fluoro-beta-alanine and 5-fluorouracil splitting from tegafur in human tumor ] . | NA | {
"id": "C0041917",
"name": "uracil",
"pos": [
12,
18
]
} | {
"id": "C0016360",
"name": "5-fluorouracil",
"pos": [
101,
115
]
} |
[ effect of uracil on the both reactions , 5-fluorouracil degradation into 2-fluoro-beta-alanine and 5-fluorouracil splitting from tegafur in human tumor ] . | NA | {
"id": "C0016360",
"name": "5-fluorouracil",
"pos": [
43,
57
]
} | {
"id": "C0016778",
"name": "tegafur",
"pos": [
131,
138
]
} |
birth weight has a significant effect on slope with a lower weight predisposing to a lower slope . | NA | {
"id": "C0005612",
"name": "birth weight",
"pos": [
0,
12
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
60,
66
]
} |
high concentrations of the other aromatic amino acid ( tyrosine ) on the other hand , were often encountered and seem to be due to immaturity of an isolated hepatic enzyme as there was no correlation between phenylalanine and tyrosine concentrations . | NA | {
"id": "C0301713",
"name": "aromatic",
"pos": [
33,
41
]
} | {
"id": "C0031453",
"name": "phenylalanine",
"pos": [
208,
221
]
} |
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