text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
high concentrations of the other aromatic amino acid ( tyrosine ) on the other hand , were often encountered and seem to be due to immaturity of an isolated hepatic enzyme as there was no correlation between phenylalanine and tyrosine concentrations . | NA | {
"id": "C0301713",
"name": "aromatic",
"pos": [
33,
41
]
} | {
"id": "C0041485",
"name": "tyrosine",
"pos": [
226,
234
]
} |
a specific and sensitive assay was performed to detect both anti-ss-a/ro and anti-ss-b/la antibodies in sera of patients with autoimmune diseases , including systemic lupus erythematosus ( sle ) , progressive systemic sclerosis ( pss ) , sjogren 's syndrome ( ss ) , discoid lupus erythematosus ( dle ) , mixed connectiv... | NA | {
"id": "C0004364",
"name": "autoimmune diseases",
"pos": [
126,
145
]
} | {
"id": "C0024141",
"name": "systemic lupus erythematosus",
"pos": [
158,
186
]
} |
hepatic p-nitrophenol hydroxylase , an enzyme , catalyzed principally by the ethanol inducible cytochrome p-450 isozyme , was also significantly induced ( 58 % ) by topically applied clotrimazole . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
39,
45
]
} | {
"id": "C0022173",
"name": "isozyme",
"pos": [
112,
119
]
} |
epoetin alfa is a glycoprotein with the same dna structure and biological effects as endogenous erythropoietin . | NA | {
"id": "C0357126",
"name": "epoetin alfa",
"pos": [
0,
12
]
} | {
"id": "C0014822",
"name": "erythropoietin",
"pos": [
96,
110
]
} |
the two patients developing mild leucopenia had hla-dr2 and the one developing agranulocytosis had hla-dr4 . | NA | {
"id": "C0023530",
"name": "leucopenia",
"pos": [
33,
43
]
} | {
"id": "C0001824",
"name": "agranulocytosis",
"pos": [
79,
94
]
} |
igm isotype antibodies to the d peptide were significantly more prevalent than igg isotype antibodies , whereas antibodies to the 68 kd polypeptide were of both igm and igg isotypes . | NA | {
"id": "C0020852",
"name": "igg",
"pos": [
79,
82
]
} | {
"id": "C0021017",
"name": "isotype",
"pos": [
173,
180
]
} |
igm isotype antibodies to the d peptide were significantly more prevalent than igg isotype antibodies , whereas antibodies to the 68 kd polypeptide were of both igm and igg isotypes . | NA | {
"id": "C0021017",
"name": "isotype",
"pos": [
4,
11
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
112,
122
]
} |
the current study was designed to determine the effect of this bacteremia and endotoxemia on survival . | NA | {
"id": "C0004610",
"name": "bacteremia",
"pos": [
63,
73
]
} | {
"id": "C0376618",
"name": "endotoxemia",
"pos": [
78,
89
]
} |
thirty multiply injured blunt-trauma patients at high risk for development of ards ( multisystem trauma including more than one organ or extremity , injury severity score of 26 or more , hypotension and need for 1500 ml or more blood within the first hour after admission , and pao2 less than or equal to 70 torr ) were ... | NA | {
"id": "C0043253",
"name": "blunt-trauma",
"pos": [
24,
36
]
} | {
"id": "C0043251",
"name": "trauma",
"pos": [
97,
103
]
} |
pulmonary artery banding was also used in patients with d-transposition of the great vessels with ventricular septal defect , double-outlet right ventricle , univentricular heart , tricuspid atresia , and truncus arteriosus . | NA | {
"id": "C0040761",
"name": "transposition of the great vessels",
"pos": [
58,
92
]
} | {
"id": "C0013069",
"name": "double-outlet right ventricle",
"pos": [
126,
155
]
} |
in mouse atria , angiotensin ii ( 0.01 microm ) enhanced the stimulation-induced ( s-i ) noradrenaline release and this was blocked by saralasin ( 0.1 microm ) . | NA | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
17,
31
]
} | {
"id": "C0036193",
"name": "saralasin",
"pos": [
135,
144
]
} |
in rat tail artery , the facilitatory effect of angiotensin ii ( 0.01 microm ) on noradrenaline release was blocked by saralasin ( 0.1 microm ) . | NA | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
48,
62
]
} | {
"id": "C0036193",
"name": "saralasin",
"pos": [
119,
128
]
} |
cocaine hydrochloride ( 50 mg ) pellets implanted s.c. in rats prior to the i.p . injections of sodium barbital ( 150 mg/kg dose once daily for 4 days ) potentiated the hypothermic response 2 hr after the barbital injection , when maximum hypothermia occurred . | NA | {
"id": "C0770386",
"name": "sodium barbital",
"pos": [
96,
111
]
} | {
"id": "C0004743",
"name": "barbital",
"pos": [
205,
213
]
} |
concentrations of glutamate , gamma-aminobutyric acid ( gaba ) , glycine , beta-alanine and taurine were measured in microdissected areas of the rostral ventrolateral medulla ( rvl ) , nucleus tractus solitarii ( nts ) and caudal ventrolateral medulla ( cvl ) of the rat , and the effects of hydralazine-induced hypotens... | NA | {
"id": "C0017890",
"name": "glycine",
"pos": [
65,
72
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
349,
360
]
} |
effect of various 6-dehydro-corticosteroids , 9 , 11-dehydro-doca and 9 alpha-fluoro-doca on the fluxes of sodium and potassium . | NA | {
"id": "C0813203",
"name": "11",
"pos": [
50,
52
]
} | {
"id": "C0011710",
"name": "doca",
"pos": [
85,
89
]
} |
the sex pheromone system of enterococcus faecalis is responsible for the clumping response of a plasmid carrying donor strain with a corresponding plasmid free recipient strain due to the production of sex pheromones by the recipient strain . | NA | {
"id": "C0031516",
"name": "pheromone",
"pos": [
8,
17
]
} | {
"id": "C0036863",
"name": "sex pheromones",
"pos": [
202,
216
]
} |
in alkaline milieu ( ph 8.5 ) , after prolonged contact with air ( 2 h ) , or after growth with excess sulfate or thiosulfate as electron acceptor , the amount taken up was diminished approximately by half . | NA | {
"id": "C0038720",
"name": "sulfate",
"pos": [
103,
110
]
} | {
"id": "C0039950",
"name": "thiosulfate",
"pos": [
114,
125
]
} |
propylene glycol esters of alginate and o-acetylated bacterial alginates were poorly degraded by the lyase compared with unmodified polysaccharide . | NA | {
"id": "C0002040",
"name": "alginates",
"pos": [
63,
72
]
} | {
"id": "C0032594",
"name": "polysaccharide",
"pos": [
132,
146
]
} |
a review of cross-gender taxonomies shows that previous observers have identified and labeled a homosexual type far more consistently than any other category of male gender dysphoric . | NA | {
"id": "C0079399",
"name": "gender",
"pos": [
18,
24
]
} | {
"id": "C0086582",
"name": "male gender",
"pos": [
161,
172
]
} |
in the young animals given hydrocortisone in dose 5 mg/kg of the body mass , the mean summational area and extension of the granular endoplasmic reticulum membranes in the fibroblast section diminishes , the summational area of the mitochondrial section decreases in the section of one cell , and the derm with less thic... | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
172,
182
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
286,
290
]
} |
the presence of cerebrospinal fluid lactic acidosis and hypoglycorrhachia suggests that intracellular acidosis or cellular energy depletion may play a role . | NA | {
"id": "C0001125",
"name": "lactic acidosis",
"pos": [
36,
51
]
} | {
"id": "C0001122",
"name": "acidosis",
"pos": [
102,
110
]
} |
two of our patients were referred to the hospital as malignant bone tumours -- ewing sarcoma and osteosarcoma . | NA | {
"id": "C0553580",
"name": "ewing sarcoma",
"pos": [
79,
92
]
} | {
"id": "C0029463",
"name": "osteosarcoma",
"pos": [
97,
109
]
} |
three monoclonal antibodies ( mabs ) reactive against two structural proteins -- the nucleoprotein ( np ) or the surface ( s ) protein -- of avian infectious bronchitis virus ( ibv ) were produced and characterized . | NA | {
"id": "C0028612",
"name": "nucleoprotein",
"pos": [
85,
98
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
127,
134
]
} |
'analgesic rebound headache ' is identified by habituation of an individual to pain reducing medication , the exacerbation of headache pain a few hours after medication consumption and a marked increase in headache frequency and intensity for several weeks after medication is discontinued . | NA | {
"id": "C0018681",
"name": "headache",
"pos": [
19,
27
]
} | {
"id": "C0030193",
"name": "pain",
"pos": [
135,
139
]
} |
however , the groups did differ on subjective headache pain ( with the high medicators experiencing more headache pain than low medicators ) and diagnosis ( with high medicators being more likely to have a muscle contraction component to their headaches ) . | NA | {
"id": "C0018681",
"name": "headache",
"pos": [
46,
54
]
} | {
"id": "C0030193",
"name": "pain",
"pos": [
114,
118
]
} |
fish arylsulfatases ( arylsulfate sulfohydrolase ; ec 3.1.6.1 ) were resolved into cationic arylsulfatase a-like ( arsa ) and anionic arylsulfatase b-like ( arsb ) fractions by deae-sephacel chromatography . | NA | {
"id": "C0003940",
"name": "arylsulfate sulfohydrolase",
"pos": [
22,
48
]
} | {
"id": "C0007804",
"name": "arsa",
"pos": [
115,
119
]
} |
fish arylsulfatases ( arylsulfate sulfohydrolase ; ec 3.1.6.1 ) were resolved into cationic arylsulfatase a-like ( arsa ) and anionic arylsulfatase b-like ( arsb ) fractions by deae-sephacel chromatography . | NA | {
"id": "C0003940",
"name": "arylsulfate sulfohydrolase",
"pos": [
22,
48
]
} | {
"id": "C0376159",
"name": "arylsulfatase b",
"pos": [
134,
149
]
} |
even though the cells were defective in phosphatidylcholine biosynthesis , the albumin-stimulated release of lysophosphatidylcholine ( 1.9 nmol/h per mg of cellular protein ) was similar to that in hepatocytes supplemented with choline . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
79,
86
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
165,
172
]
} |
these results resemble those obtained by de medicis & rossignol [ ( 1979 ) experientia 35 , 1546-1547 ] with the pyruvate kinase from v. costicola , and agree with the proposal by lanyi [ ( 1974 ) bacteriol . rev . 38 , 272-290 ] of partial replacement of hydrophobic amino acids by glycine and serine to maintain the ba... | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
268,
279
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
283,
290
]
} |
the results show that muscarinic-receptor activation involves phosphoinositidase c-catalysed hydrolysis initially of polyphosphoinositides rather than of phosphatidylinositol . | NA | {
"id": "C0071655",
"name": "polyphosphoinositides",
"pos": [
117,
138
]
} | {
"id": "C0031621",
"name": "phosphatidylinositol",
"pos": [
154,
174
]
} |
isolated islets of the rat labelled with myo- [ 3h ] inositol showed decreased accumulation of total inositol phosphates ( insps ) and [ 3h ] polyphosphoinositide hydrolysis in response to glucose after preincubation with prostaglandin e2 ( pge2 ) . | NA | {
"id": "C0021547",
"name": "inositol",
"pos": [
53,
61
]
} | {
"id": "C0021554",
"name": "inositol phosphates",
"pos": [
101,
120
]
} |
sensitive assays for the determination of the ganglioside sialidase activity of fibroblast homogenates were established using ganglioside gm3 , 3h-labelled in the sphingosine moiety , as a substrate . | NA | {
"id": "C0017082",
"name": "ganglioside",
"pos": [
46,
57
]
} | {
"id": "C0016897",
"name": "ganglioside gm3",
"pos": [
126,
141
]
} |
the present studies examined the effect of agents that induce peroxisomal and mitochondrial beta-oxidation on hepatic mitochondrial carnitine palmitoyltransferase ( cpt ) and peroxisomal carnitine acyltransferase [ cpts of ramsay ( 1988 ) biochem . j . 249 , 239-245 ; cot of farrell & bieber ( 1983 ) arch . biochem . b... | NA | {
"id": "C0007262",
"name": "carnitine",
"pos": [
132,
141
]
} | {
"id": "C0007261",
"name": "carnitine acyltransferase",
"pos": [
187,
212
]
} |
studies of binding in vitro performed with microtubules and with purified microtubule proteins showed that mitochondria preferentially interact with the high-molecular-mass maps ( and not with tau protein ) . | NA | {
"id": "C0026042",
"name": "microtubule proteins",
"pos": [
74,
94
]
} | {
"id": "C0026045",
"name": "maps",
"pos": [
173,
177
]
} |
studies of binding in vitro performed with microtubules and with purified microtubule proteins showed that mitochondria preferentially interact with the high-molecular-mass maps ( and not with tau protein ) . | NA | {
"id": "C0026045",
"name": "maps",
"pos": [
173,
177
]
} | {
"id": "C0085401",
"name": "tau",
"pos": [
193,
196
]
} |
the expected decrease in spermidine-mediated suppression of odc and adometdc was most probably counteracted by the simultaneous increase in spermine . | NA | {
"id": "C0037871",
"name": "mediated",
"pos": [
36,
44
]
} | {
"id": "C0037874",
"name": "spermine",
"pos": [
140,
148
]
} |
concomitant with this rise , the putrescine and spermidine contents increased , whereas that of spermine remained virtually unchanged . | NA | {
"id": "C0034170",
"name": "putrescine",
"pos": [
33,
43
]
} | {
"id": "C0037871",
"name": "contents",
"pos": [
59,
67
]
} |
concomitant with this rise , the putrescine and spermidine contents increased , whereas that of spermine remained virtually unchanged . | NA | {
"id": "C0037871",
"name": "contents",
"pos": [
59,
67
]
} | {
"id": "C0037874",
"name": "spermine",
"pos": [
96,
104
]
} |
our findings provide strong evidence that in these tissues d-aspartate oxidase is a peroxisomal-matrix protein and should be added as an additional flavoprotein oxidase to the known set of peroxisomal oxidases . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
103,
110
]
} | {
"id": "C0016223",
"name": "flavoprotein",
"pos": [
148,
160
]
} |
we have studied the effect of carbachol and histamine on guanosine 5'- [ gamma-thio ] triphosphate ( gtp [ s ] ) stimulation of inositol phosphates formation in [ 3h ] inositol-labelled rat brain cortical membranes . | NA | {
"id": "C0021554",
"name": "inositol phosphates",
"pos": [
128,
147
]
} | {
"id": "C0021547",
"name": "inositol",
"pos": [
168,
176
]
} |
under these conditions , stimulated production of [ 3h ] inositol phosphates was linear for at least 15 min , and [ 3h ] inositol bisphosphate [ ( 3h ] ip2 ) accounted for approx . | NA | {
"id": "C0021554",
"name": "inositol phosphates",
"pos": [
57,
76
]
} | {
"id": "C0021547",
"name": "inositol",
"pos": [
121,
129
]
} |
the effect of insulin on apolipoprotein ( apo b ) secretion was studied in 24 h recirculating liver perfusions of isolated normal , diabetic and insulin-treated diabetic rats . | NA | {
"id": "C0003591",
"name": "apolipoprotein",
"pos": [
25,
39
]
} | {
"id": "C0003593",
"name": "apo b",
"pos": [
42,
47
]
} |
these results suggest that human factor xa , at physiological concentrations , could activate human protein c in the presence of anionic phospholipids and that this activation could be potentiated by therapeutic concentrations of sulphated polysaccharides . | NA | {
"id": "C0003075",
"name": "anionic",
"pos": [
129,
136
]
} | {
"id": "C0038720",
"name": "sulphated",
"pos": [
230,
239
]
} |
both monokines decreased the blood concentrations of those amino acids ( serine , glycine , alanine and proline ) transported via the a system . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
59,
70
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
82,
89
]
} |
both monokines decreased the blood concentrations of those amino acids ( serine , glycine , alanine and proline ) transported via the a system . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
59,
70
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
92,
99
]
} |
our results demonstrate that chymotrypsin can activate the maximal velocity of n-ethylmaleimide ( nem ) -sensitive carnitine or palmitoylcarnitine exchange 7-fold , while doubling the affinity of the translocase for carnitine . | NA | {
"id": "C0030242",
"name": "palmitoylcarnitine",
"pos": [
128,
146
]
} | {
"id": "C0007258",
"name": "carnitine",
"pos": [
216,
225
]
} |
the property of calcium-dependent binding of lipocortin to the particulate fraction was used to prepare cytosolic and particulate subcellular fractions which contained phospholiphase a2 activity but no lipocortin-i . | NA | {
"id": "C0065042",
"name": "lipocortin",
"pos": [
45,
55
]
} | {
"id": "C0103403",
"name": "lipocortin-i",
"pos": [
202,
214
]
} |
the cytosolic enzyme only exerts significant control when its complement is decreased 3-5-fold , and differs from the plastid isoenzyme in exerting more control in low light intensity . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
14,
20
]
} | {
"id": "C0022173",
"name": "isoenzyme",
"pos": [
126,
135
]
} |
stimulation of the isolated perfused liver by the combined infusion of the phorbol ester 12-o-tetradecanoylphorbol-13-acetate ( tpa ) and the ca2+ ionophore a23187 results in a transient increase of endogenous cysteinyl lt production , which is independent of extrahepatic cells . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
75,
88
]
} | {
"id": "C0039654",
"name": "12-o-tetradecanoylphorbol-13-acetate",
"pos": [
89,
125
]
} |
the plasma-membrane ca2+-transport atpase from erythrocytes was 20 times less sensitive to inhibition by aif4- as compared with the ca2+-transport atpase from smooth muscle . | NA | {
"id": "C0300252",
"name": "plasma-membrane ca2",
"pos": [
4,
23
]
} | {
"id": "C0001476",
"name": "ca2",
"pos": [
132,
135
]
} |
the endoplasmic-reticulum ca2+-transport atpase from smooth muscle was inhibited to a greater extent than the sarcoplasmic-reticulum ca2+-transport atpase of slow and fast skeletal muscle . | NA | {
"id": "C0001476",
"name": "ca2",
"pos": [
26,
29
]
} | {
"id": "C0916181",
"name": "sarcoplasmic-reticulum",
"pos": [
110,
132
]
} |
the antilipolytic effects and the cyclic-amp-lowering effects of the polyamines were almost completely prevented in the presence of different phosphodiesterase ( pde ) inhibitors ( 3-isobutyl-1-methylxanthine and ro 20-1724 ) and , in addition , polyamines had no effect on lipolysis stimulated by dibutyryl cyclic amp ,... | NA | {
"id": "C0001455",
"name": "cyclic-amp",
"pos": [
34,
44
]
} | {
"id": "C0012054",
"name": "dibutyryl cyclic amp",
"pos": [
298,
318
]
} |
the mucolytic specific activity ( rate of mucus peptide bond hydrolysis by bacterial protein ) of the fractions tested from both organisms did not exceed 2nmol/min/mg protein . | NA | {
"id": "C0004627",
"name": "bacterial protein",
"pos": [
75,
92
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
167,
174
]
} |
the findings demonstrate that the human adipocyte adenosine receptor is similar to the a1 adenosine receptor of rat adipocytes , although its molecular weight is higher , and its affinity for hpia is lower than that of the rat . | NA | {
"id": "C0001471",
"name": "adenosine receptor",
"pos": [
50,
68
]
} | {
"id": "C0001451",
"name": "a1 adenosine receptor",
"pos": [
87,
108
]
} |
proalbumin is processed to serum albumin in cos-1 cells transfected with cdna for rat albumin . | NA | {
"id": "C0032923",
"name": "proalbumin",
"pos": [
0,
10
]
} | {
"id": "C0036773",
"name": "serum albumin",
"pos": [
27,
40
]
} |
analysis using isoelectric focusing revealed that serum-type albumin , which is indistinguishable from the counterpart isolated from rat hepatocyte cuture medium , was secreted from the transfected cos-1 cells , indicating that proalbumin is effectively converted into serum albumin in the cos-1 cells , if not completel... | NA | {
"id": "C0032923",
"name": "proalbumin",
"pos": [
228,
238
]
} | {
"id": "C0036773",
"name": "serum",
"pos": [
269,
274
]
} |
furthermore methylamine was found to cause the diminution of serum albumin released from the cells , substantiating that the proteolytical conversion of proalbumin occurs in the golgi complex before discharge from the cos-1 cells . | NA | {
"id": "C0036773",
"name": "serum albumin",
"pos": [
61,
74
]
} | {
"id": "C0032923",
"name": "proalbumin",
"pos": [
153,
163
]
} |
the 5k cardiac natriuretic peptide , or bnp [ 51-95 ] , was identified as the major storage and secretory form derived from the bnp precursor in the rat heart . | NA | {
"id": "C1144709",
"name": "natriuretic peptide",
"pos": [
15,
34
]
} | {
"id": "C0054015",
"name": "bnp",
"pos": [
128,
131
]
} |
low molecular weight heparin inhibited inositol 1,4,5-trisphosphate ( insp3 ) induced ca2+ release ( ic50 = 0.8 microgram/ml ) , but not guanosine 5'-o- ( 3-thio triphosphate ) ( gtp gamma s ) stimulated ca2+ release . | NA | {
"id": "C0018353",
"name": "guanosine",
"pos": [
137,
146
]
} | {
"id": "C0079469",
"name": "gtp gamma s",
"pos": [
179,
190
]
} |
pretreatment with 8-bromo-camp ( 10 ( -3 ) m ) , a phorbol ester ( pma 10 ( -7 ) m ) + ionophore a23187 ( 10 ( -7 ) m ) produced a positive regulation of igf-i receptors . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
51,
64
]
} | {
"id": "C0039654",
"name": "pma",
"pos": [
67,
70
]
} |
a number of genes are transcriptionally regulated by interferons via a cis acting regulatory element ( interferon consensus sequence ) . | NA | {
"id": "C0021747",
"name": "interferons",
"pos": [
53,
64
]
} | {
"id": "C0164613",
"name": "interferon consensus",
"pos": [
103,
123
]
} |
this il1 activity was found to be exerted to the same extent both by human and murine il1-alpha or il1-beta , and was also different from the sensitization obtained with galactosamine , since these agents had an additive effect . | NA | {
"id": "C0021755",
"name": "il1",
"pos": [
5,
8
]
} | {
"id": "C0600251",
"name": "il1-alpha",
"pos": [
86,
95
]
} |
endothelin ( et ) -related peptides including et-1 ( 1-39 ) were synthesized , and their constricting activity in rat pulmonary artery rings and pressor activity in unanesthetized rat were measured to elucidate their structure-activity relationship . | NA | {
"id": "C0079284",
"name": "endothelin",
"pos": [
0,
10
]
} | {
"id": "C0079281",
"name": "et-1",
"pos": [
46,
50
]
} |
significant activities were retained even with replacement of amino acids at positions ser4 , ser5 , leu6 , met7 , lys9 , tyr13 , and trp21 by ala , ala , gly , met ( 0 ) , leu , phe , and tyr or phe , respectively . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
62,
73
]
} | {
"id": "C0017890",
"name": "gly",
"pos": [
155,
158
]
} |
the apolipoprotein a-containing lipoproteins separated from apolipoprotein b-containing lipoproteins by affinity chromatography of culture medium on concanavalin a were fractionated on an immunosorber with monoclonal antibodies to apolipoprotein a-ii . | NA | {
"id": "C0003592",
"name": "apolipoprotein a",
"pos": [
4,
20
]
} | {
"id": "C0085202",
"name": "apolipoprotein a-ii",
"pos": [
231,
250
]
} |
the retained fraction contained apolipoproteins a-i , a-ii and e , while the unretained fraction contained apolipoproteins a-i and e . | NA | {
"id": "C0085201",
"name": "apolipoproteins a-i",
"pos": [
32,
51
]
} | {
"id": "C0003592",
"name": "apolipoproteins a",
"pos": [
107,
124
]
} |
further chromatography of both fractions on an immunosorber with monoclonal antibodies to apolipoprotein a-i showed that 1 ) apolipoprotein a-ii only occurs in association with apolipoprotein a-i , 2 ) apolipoprotein a-iv is only present as part of a separate lipoprotein family ( lipoprotein a-iv ) , and 3 ) apolipopro... | NA | {
"id": "C0085202",
"name": "apolipoprotein a-ii",
"pos": [
125,
144
]
} | {
"id": "C0003592",
"name": "apolipoprotein a",
"pos": [
392,
408
]
} |
further chromatography of both fractions on an immunosorber with monoclonal antibodies to apolipoprotein a-i showed that 1 ) apolipoprotein a-ii only occurs in association with apolipoprotein a-i , 2 ) apolipoprotein a-iv is only present as part of a separate lipoprotein family ( lipoprotein a-iv ) , and 3 ) apolipopro... | NA | {
"id": "C0085201",
"name": "apolipoprotein a-i",
"pos": [
90,
108
]
} | {
"id": "C0003592",
"name": "apolipoprotein a",
"pos": [
392,
408
]
} |
further chromatography of both fractions on an immunosorber with monoclonal antibodies to apolipoprotein a-i showed that 1 ) apolipoprotein a-ii only occurs in association with apolipoprotein a-i , 2 ) apolipoprotein a-iv is only present as part of a separate lipoprotein family ( lipoprotein a-iv ) , and 3 ) apolipopro... | NA | {
"id": "C0065058",
"name": "lipoprotein a",
"pos": [
93,
106
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
420,
432
]
} |
the amino acid composition was notable for high contents of acidic amino acids ( 15.0 mol % of glutamic acid and 8.1 mol % of aspartic acid ) and 17.4 mol % of alanine . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
4,
14
]
} | {
"id": "C0815040",
"name": "acidic amino",
"pos": [
60,
72
]
} |
the amino acid composition was notable for high contents of acidic amino acids ( 15.0 mol % of glutamic acid and 8.1 mol % of aspartic acid ) and 17.4 mol % of alanine . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
4,
14
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
160,
167
]
} |
the amino acid composition was notable for high contents of acidic amino acids ( 15.0 mol % of glutamic acid and 8.1 mol % of aspartic acid ) and 17.4 mol % of alanine . | NA | {
"id": "C0815040",
"name": "acidic amino",
"pos": [
60,
72
]
} | {
"id": "C0004015",
"name": "aspartic acid",
"pos": [
126,
139
]
} |
enzymatic digestion of the proteoglycans indicated that both large and small molecular weight chondroitin sulfate proteoglycans were markedly elevated , while dermatan sulfate and heparan sulfate proteoglycans were increased to a lesser extent . | NA | {
"id": "C0033692",
"name": "proteoglycans",
"pos": [
27,
40
]
} | {
"id": "C0033689",
"name": "chondroitin sulfate proteoglycans",
"pos": [
94,
127
]
} |
analysis of fatty acids bound to the isolated human and bovine dbp showed molar ratios of fatty acid to protein of 0.4 and 1.3 respectively meanwhile human and bovine albumin have bound 1.8 and 1.5 moles per mol respectively . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
104,
111
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
167,
174
]
} |
most of fatty acids bound to human and bovine dbp are monounsaturated and saturated , mainly oleic and palmitic acids , which together account for 50 % of the total of fatty acids in both species . | NA | {
"id": "C0030235",
"name": "palmitic acids",
"pos": [
103,
117
]
} | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
168,
179
]
} |
although the time course of [ 14c ] hete accumulation was identical with 60 microm lf 1695 and calcium ionophore a23187 , the latter compound also promoted the formation of 14c-labelled thromboxane b2 and 12- ( s ) -hydroxy-5,8,10-heptadecatrienoic acid ( hht ) , whereas 12-hete was the only arachidonic acid metabolite... | NA | {
"id": "C0020349",
"name": "hete",
"pos": [
36,
40
]
} | {
"id": "C0044800",
"name": "12-hete",
"pos": [
272,
279
]
} |
these results demonstrate that several sulfur-containing amino acids , some of which have been proposed to be endogenous excitatory amino acid neurotransmitters , effectively modulate the response to norepinephrine of the phosphoinositide second messenger system in rat brain . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
57,
68
]
} | {
"id": "C0243046",
"name": "excitatory amino acid",
"pos": [
121,
142
]
} |
finally , the apparent lack of binding selectivity of these new photo-affinity probes towards muscarinic receptor affinity states or subtypes should allow comparative studies of the acetylcholine binding site on different muscarinic receptor proteins , obtained either through purification procedures or expression of se... | NA | {
"id": "C0034792",
"name": "acetylcholine binding site",
"pos": [
182,
208
]
} | {
"id": "C0034826",
"name": "muscarinic receptor proteins",
"pos": [
222,
250
]
} |
this inhibition by sod was most prominent in the absence of added iron and less pronounced in the presence of ferric-atp or ferric-citrate . | NA | {
"id": "C0302583",
"name": "iron",
"pos": [
66,
70
]
} | {
"id": "C0060231",
"name": "ferric-citrate",
"pos": [
124,
138
]
} |
chromatography was performed with a mobile phase consisting of methanol , ethanol and water , the atmosphere in the tank being saturated with ammonia . | NA | {
"id": "C0001963",
"name": "methanol",
"pos": [
63,
71
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
74,
81
]
} |
the effects of the novel alkylxanthine denbufylline ( 1,3-d-n-butyl-7- ( 2'-oxopropyl ) -xanthine ) , theophylline and 3-isobutyl-1-methyl-xanthine ( ibmx ) , on the breakdown of cyclic amp in homogenates of rat erythrocytes , abdominal aorta , adipocytes and cardiac and skeletal muscle were studied . | NA | {
"id": "C0039771",
"name": "theophylline",
"pos": [
102,
114
]
} | {
"id": "C0000096",
"name": "3-isobutyl-1-methyl-xanthine",
"pos": [
119,
147
]
} |
the characteristics of bunazosin binding to alpha-adrenoceptors in the porcine aortic membranes were investigated using [ 3h ] prazosin and [ 3h ] yohimbine binding assays to identify alpha 1- and alpha 2-adrenoceptors , respectively . | NA | {
"id": "C0034784",
"name": "alpha-adrenoceptors",
"pos": [
44,
63
]
} | {
"id": "C0001639",
"name": "alpha 2-adrenoceptors",
"pos": [
197,
218
]
} |
the management of the administration of leucovorin ( leucovorin calcium , calcium folinate , inn ; citrovorum factor ) which is directly dependent on the serum level of mtx , is exactly shown in the discussion . | NA | {
"id": "C0731033",
"name": "calcium folinate",
"pos": [
74,
90
]
} | {
"id": "C0023413",
"name": "citrovorum factor",
"pos": [
99,
116
]
} |
cl-/hco3- anion exchange inhibitors , such as sits ( 4-acetamido-4'-isothiocyanostilbene-2,2'-disulfonic acid ) or furosemide , but not the specific cotransport inhibitor bumetanide , inhibit swelling or increased ion uptake in rat brain slices caused by elevated potassium although there were marked species differences... | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
10,
15
]
} | {
"id": "C0022023",
"name": "ion",
"pos": [
214,
217
]
} |
a novel anion exchange inhibitor , l-644,711 , inhibits swelling and increased ion uptake caused by glutamate in rat and cat brain slices , as well as inhibiting [ 3h ] glutamate uptake in primary rat astrocyte cultures . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
8,
13
]
} | {
"id": "C0022023",
"name": "ion",
"pos": [
79,
82
]
} |
under the term , the epilepsies are grouped as several types of seizure processes that undoubtedly have multiple pathophysiological causes . | NA | {
"id": "C0014544",
"name": "epilepsies",
"pos": [
21,
31
]
} | {
"id": "C0036572",
"name": "seizure",
"pos": [
64,
71
]
} |
inhibition by the transition state analogs , coformycin and 2'-deoxycoformycin , was observed for both rabbit and chick deaminases with ki values approximately 1 microm and approximately 1.6 microm respectively . | NA | {
"id": "C0009239",
"name": "coformycin",
"pos": [
45,
55
]
} | {
"id": "C0030896",
"name": "2",
"pos": [
60,
61
]
} |
kinetic data for coformycin-5'-phosphate show it to be a tight-binding inhibitor with ki less than 0.6 x 10 ( -9 ) m as compared to 1 x 10 ( -9 ) m for 2'-deoxycoformycin-5'-phosphate . | NA | {
"id": "C0009239",
"name": "coformycin",
"pos": [
17,
27
]
} | {
"id": "C0030896",
"name": "deoxycoformycin",
"pos": [
155,
170
]
} |
the deduced amino acid sequence was 54-58 % identical to the approximately 70 kda subunits of sulfolobus acidocaldarius and the eukaryotic vacuolar-type h+-atpase , and only 29 % identical to the beta subunit of the eubacterial-type f0f1-atpases . | NA | {
"id": "C0379099",
"name": "vacuolar",
"pos": [
139,
147
]
} | {
"id": "C0018437",
"name": "f0f1-atpases",
"pos": [
233,
245
]
} |
phylogenetic analysis using felsenstein 's maximum likelihood method and lake 's evolutionary parsimony method confirmed that the h+-atpases of the two archaebacteria , methanococcus and sulfolobus , when compared to eukaryotic vacuolar-type atpases and eubacterial f0f1-atpases , form a monophyletic group . | NA | {
"id": "C0379099",
"name": "vacuolar",
"pos": [
228,
236
]
} | {
"id": "C0018437",
"name": "f0f1-atpases",
"pos": [
266,
278
]
} |
streptococcus rattus strains ( kay1 , fa1 and bht ) were examined by electron microscopy in whole cell-mounted samples and ultrathin sections for the localization of the type-specific antigen , using specific antiserum and ferritin-labelled anti-rabbit igg as secondary antibody . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
209,
218
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
270,
278
]
} |
virus infected monolayers , in wells of 96-well plates , could be used as antigen in competition binding assays to identify epitopes on respectively semliki forest virus , encephalomyocarditis virus and mumps virus . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
74,
81
]
} | {
"id": "C0003316",
"name": "epitopes",
"pos": [
124,
132
]
} |
the compounds , ivermectin and two benzodiazepines , diazepam and a water soluble midazolam were tested singly or in combination against two microfilarial parasites onchocerca lienalis ( closely related to onchocerca volvulus ) and brugia pahangi . | NA | {
"id": "C0005064",
"name": "benzodiazepines",
"pos": [
35,
50
]
} | {
"id": "C0026056",
"name": "midazolam",
"pos": [
82,
91
]
} |
the epitope ( s ) within this latter sequence have not yet been identified , but the experimental approach used here should make it possible to define critical t-cell epitopes in mg , and to determine their functional relevance by investigating the ability of achr-reactive t-cell clones to provide specific help in anti... | NA | {
"id": "C0003316",
"name": "epitope",
"pos": [
4,
11
]
} | {
"id": "C0282580",
"name": "t-cell epitopes",
"pos": [
160,
175
]
} |
autologous clones were raised against mx9/9 cells using the peripheral blood mononuclear ( pbm ) cells of the mx9/9 clone donor ( pbmjm ) . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
44,
49
]
} | {
"id": "C1321301",
"name": "peripheral blood mononuclear",
"pos": [
60,
88
]
} |
nmabs which map to the same epitope on the virion appear to contain a common idiotype , and the corresponding anti-ids competitively inhibited the virus-nmab reaction . | NA | {
"id": "C0003316",
"name": "epitope",
"pos": [
28,
35
]
} | {
"id": "C0021013",
"name": "idiotype",
"pos": [
77,
85
]
} |
mice were inoculated with purified anti-ids , and two elicited anti-viral antibodies , although these antibodies were non-neutralizing . | NA | {
"id": "C0003253",
"name": "anti-viral antibodies",
"pos": [
63,
84
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
102,
112
]
} |
in the targeting of chemotherapeutic agents to specific cells via covalent conjugation of the agent to monoclonal antibodies , conjugation methods which lead to maximum binding capacity with minimum loss of activity ( for both drug and antibody ) are essential . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
103,
124
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
236,
244
]
} |
this urothelial 'beta-hcg ' has the same molecular weight and electrophoretic mobility as that present in the intact hcg of pregnancy . | NA | {
"id": "C0106132",
"name": "beta-hcg",
"pos": [
17,
25
]
} | {
"id": "C0018062",
"name": "hcg",
"pos": [
117,
120
]
} |
even after a 30-min preincubation with benextramine the antagonist failed to differentiate between noradrenaline , adrenaline and clonidine with respect to inhibition of insulin secretion . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
99,
112
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
115,
125
]
} |
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