text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
the bioavailability of iron in five ferrous sulfate preparations was studied in 10 healthy male volunteers . | NA | {
"id": "C0302583",
"name": "iron",
"pos": [
23,
27
]
} | {
"id": "C0060282",
"name": "ferrous sulfate",
"pos": [
36,
51
]
} |
natural killer ( nk ) and lymphocyte activated killer ( lak ) precursor activity of peripheral blood mononuclear cells was determined before and during treatment , and expression of hla-a , b , c molecules was looked for on the tumor cells in the bone marrow of five patients . | NA | {
"id": "C1321301",
"name": "peripheral blood mononuclear cells",
"pos": [
84,
118
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
234,
239
]
} |
one cr and 5 prs were achieved among the other 13 patients with intermediate or low-grade nhl . | NA | {
"id": "C0079747",
"name": "low-grade nhl",
"pos": [
80,
93
]
} | {
"id": "C0024305",
"name": "nhl",
"pos": [
90,
93
]
} |
the database , which contains 1h- or 13c-n.m.r . chemical shift data for monosaccharides and 1h- or 13c-glycosylation shifts for all types of glycosidic linkages obtained by combination of the monosaccharides , has been increased and now also contains correction values for sugar residues present in branch-point regions... | NA | {
"id": "C0026492",
"name": "monosaccharides",
"pos": [
73,
88
]
} | {
"id": "C0007004",
"name": "sugar",
"pos": [
274,
279
]
} |
the following disaccharide glycosides were obtained in yields of 10-35 % from the appropriate donor and acceptor glycosides by employing glycosidases as catalysts : alpha-d-galp- ( 1 -- -- 3 ) -alpha-d-galpnac-oet ( alpha-d-galactosidase ) , beta-d-galp- ( 1 -- -- 3 ) -alpha-d-galpnac-oet and beta-d-galp- ( 1 -- -- 3 )... | NA | {
"id": "C0017976",
"name": "glycosidases",
"pos": [
137,
149
]
} | {
"id": "C0016955",
"name": "galactosidase",
"pos": [
352,
365
]
} |
the bacteriophages phi 41 and phi 12 are shown to hydrolyze the same alpha-galactopyranosyl bond in each of the polysaccharides , giving rise to an oligosaccharide characteristic of the starting polysaccharide , irrespective of the phage employed . | NA | {
"id": "C0028959",
"name": "oligosaccharide",
"pos": [
148,
163
]
} | {
"id": "C0032594",
"name": "polysaccharide",
"pos": [
195,
209
]
} |
the 13c-n.m.r . spectra of the capsular polysaccharide of klebsiella k41 and phage-derived oligosaccharides k41-p1 and k41-p2 were compared with spectra from the structurally similar polysaccharide of klebsiella k12 and oligosaccharides k12-p1 and k12-p2 . | NA | {
"id": "C0032594",
"name": "polysaccharide",
"pos": [
40,
54
]
} | {
"id": "C0028959",
"name": "oligosaccharides",
"pos": [
220,
236
]
} |
the antiserum interacted with some xyloglucans , such as those from tamarind seed and the cell wall of pea stem . beta-isoprimeverose and alpha-d-xylopyranosides were good inhibitors of the xyloglucan-antibody precipitation system , indicating that the antibodies recognize the beta-isoprimeverose unit of the xyloglucan... | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
4,
13
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
253,
263
]
} |
the enzymatic activity is localized in rer and perinuclear cisternae , on the plasma membrane and within the chromaffin vesicles , both in adrenaline ( a ) and noradrenaline ( n ) cells . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
139,
149
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
160,
173
]
} |
moreover , we were able to disclose some novel properties of dna restriction-modification enzymes concerning the protection of dna recognition sequences in which only one strand can be methylated ( e.g. , type iii enzyme ecop15 ) and the primary resistance of ( unmethylated ) dna recognition sites towards type ii restr... | NA | {
"id": "C0012910",
"name": "dna restriction-modification enzymes",
"pos": [
61,
97
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
214,
220
]
} |
the vacuoles occurring in rat hepatocytes after intraportal injection of retinol ( 33 or 67 micrograms ) were examined immunohistochemically using respective antibodies against rat albumin , human retinol-binding protein , human ceruloplasmin , human alpha 1-antitrypsin , human transferrin , and human prealbumin as rep... | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
181,
188
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
339,
347
]
} |
cells which enter the lytic cycle express the ebv early antigen ea , the viral capsid antigen vca , and the membrane antigen ma . | NA | {
"id": "C0003342",
"name": "viral",
"pos": [
73,
78
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
117,
124
]
} |
the largest dth-inducing hybrid protein contained the n-terminal 350 amino acids of e2 and part of e3 , the smallest contained only the region from amino acid residues 115 to 151 of the e2 membrane protein without any other sfv protein parts . | NA | {
"id": "C0025252",
"name": "membrane protein",
"pos": [
189,
205
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
228,
235
]
} |
exposure of hamster fibroblast nil8 cells for 1-3 hr to latrunculin a , latrunculin b , and cytochalasin d causes concentration-dependent changes in cell shape and actin organization . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
20,
30
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
149,
153
]
} |
myosin was detected by monoclonal antibodies to dictyostelium myosin heavy chain followed by a fluorescent secondary antibody that had been preabsorbed to remove nonspecific staining . | NA | {
"id": "C0027096",
"name": "myosin",
"pos": [
0,
6
]
} | {
"id": "C0027100",
"name": "myosin heavy",
"pos": [
62,
74
]
} |
analysis of mouse swiss/3t3 fibroblasts and rat hepatoma h35 cells using the affinity cross-linking method revealed multiple forms of 125i-insulin binding components ( mr greater than 300,000 ) in the absence of reducing agents . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
28,
39
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
61,
66
]
} |
over-sulfated disaccharide units such as di- or trisulfated unsaturated disaccharides in urine were estimated and unsaturated 6-sulfated disaccharide ( delta di-6s ) was found as a major component from chs in urine , although only small amounts of delta di-6s from chs were present in serum . | NA | {
"id": "C0008454",
"name": "chs",
"pos": [
202,
205
]
} | {
"id": "C0008466",
"name": "chs",
"pos": [
265,
268
]
} |
relatively high concentrations of mk-733 ( simvastatin ) and mk-803 ( lovastatin , mevinolin ) , which are 3-hydroxy-3-methylglutaryl coenzyme a ( hmg-coa ) reductase inhibitors , were found to inhibit acyl coenzyme a : cholesterol acyltransferase ( acat ) of rabbit intestinal microsomes with ic50 's of 2.0 x 10 ( -5 )... | NA | {
"id": "C0074554",
"name": "simvastatin",
"pos": [
43,
54
]
} | {
"id": "C0024027",
"name": "mevinolin",
"pos": [
83,
92
]
} |
plasma levels of fibrinopeptide a ( fpa ) , fibrinopeptide b beta 15-42 ( fpb beta 15-42 ) , high molecular weight kininogen ( hmw-kg ) , kinin , prekallikrein and kallikrein inhibitor during pregnancy , labor , cesarean section and puerperium were studied in 170 cases of full term normal delivery and 20 cases of cesar... | NA | {
"id": "C0033024",
"name": "prekallikrein",
"pos": [
146,
159
]
} | {
"id": "C0022478",
"name": "kallikrein",
"pos": [
164,
174
]
} |
significant decrease of hmw-kg during normal labor and also significant decrease of prekallikrein and kallikrein inhibitor after cesarean section were also seen . | NA | {
"id": "C0033024",
"name": "prekallikrein",
"pos": [
84,
97
]
} | {
"id": "C0022478",
"name": "kallikrein",
"pos": [
102,
112
]
} |
however , gel filtration of cortex material to remove low molecular components including corticosteroid hormones failed to reveal any ntf activity in these preparations . | NA | {
"id": "C0001617",
"name": "corticosteroid",
"pos": [
89,
103
]
} | {
"id": "C0019932",
"name": "hormones",
"pos": [
104,
112
]
} |
new reagents created in this way include murine antibodies whose constant regions and variable-region frameworks have been replaced with human sequence to enhance immunocompatibility with patients , to switch immunoglobulin class , or both . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
48,
58
]
} | {
"id": "C0021017",
"name": "immunoglobulin",
"pos": [
209,
223
]
} |
this new method for determining pancreatic isoamylase ( ec 3.2.1.1 ) in serum involves two monoclonal antibodies : one immobilized in a microtitration well ( the capture antibody ) , the other biotinylated . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
91,
112
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
170,
178
]
} |
most plasma homocysteine ( about 70 % ) is protein bound , probably via a disulfide bond to albumin , whereas homocysteine-cysteine mixed disulfide is the predominating form in the free fraction . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
43,
50
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
92,
99
]
} |
in hypothyroid cretins ( tsh greater than 10 miu/l ) , ct imaging of the pituitary revealed adenoma in five of 20 ( 25 % ) and partially empty sella ( pes ) in a further eight of 20 ( 40 % ) . | NA | {
"id": "C0032002",
"name": "pituitary",
"pos": [
73,
82
]
} | {
"id": "C0014008",
"name": "empty sella",
"pos": [
137,
148
]
} |
we characterized the nuclear proteins with specific binding ability against c-myc gene by gel-shift assay in cell extracts of peripheral blood mononuclear cells ( pbmc ) from sle patients and sle-prone mice with use of distinct c-myc fragments . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
109,
113
]
} | {
"id": "C1321301",
"name": "peripheral blood mononuclear",
"pos": [
126,
154
]
} |
the c1 was shown to be inducible in pbmc from healthy persons without nascent protein synthesis after lectin binding to the cell and found to be elevated in the sle patients and in all of the established cell lines we examined . | NA | {
"id": "C1321301",
"name": "pbmc",
"pos": [
36,
40
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
204,
208
]
} |
these values were significantly increased as compared with the circulating t and b cells from 22 healthy subjects in whom tcr gamma delta+t cells were 2.09 +/- 1.01 ( p less than 0.001 for ra ; p less than 0.004 for ss ) and cd5+b cells were 18.09 % +/- 4.47 ( p less than 0.001 for ra and ss ) . | NA | {
"id": "C0003873",
"name": "ra",
"pos": [
189,
191
]
} | {
"id": "C1527336",
"name": "ss",
"pos": [
290,
292
]
} |
in contrast , a progressive increase in igg1 anti-tg affinity was seen in clinically euthyroid individuals compared with their relatives with thyroid disease and high titred hashimoto 's disease patients , suggesting that either rising titres of high affinity igg1 anti-tg or affinity maturation of igg1 anti-tg may be i... | NA | {
"id": "C0040128",
"name": "thyroid disease",
"pos": [
142,
157
]
} | {
"id": "C0020676",
"name": "hypothyroidism",
"pos": [
343,
357
]
} |
alloreactive lymphocytes primed against donor hla antigens ( dpl ) or unrelated hla antigens from a third party ( tpl ) were studied for their adherence to haec derived from organ transplant donors . | NA | {
"id": "C0019721",
"name": "hla antigens",
"pos": [
46,
58
]
} | {
"id": "C0019728",
"name": "hla antigens",
"pos": [
80,
92
]
} |
in order to test a published claim that the inclusion of mycobacterium leprae antigens with a tuberculin skin test reagent can suppress delayed-type hypersensitivity ( dth ) to tuberculin in both paucibacillary and multibacillary leprosy cases , 109 leprosy cases and 104 non-leprosy controls were skin-tested simultaneo... | NA | {
"id": "C1562585",
"name": "multibacillary",
"pos": [
215,
229
]
} | {
"id": "C0023343",
"name": "leprosy",
"pos": [
276,
283
]
} |
there was a clear tendency for larger dth responses with the combined tuberculin plus m. leprae antigen than with tuberculin alone in paucibacillary leprosy cases and in non-leprosy controls . | NA | {
"id": "C1562908",
"name": "paucibacillary leprosy",
"pos": [
134,
156
]
} | {
"id": "C0023343",
"name": "leprosy",
"pos": [
174,
181
]
} |
autoantibodies to the intermediate filament proteins vimentin and keratin were studied in sera of 50 caribbean patients with schistosoma mansoni infection and 50 control subjects . | NA | {
"id": "C0021769",
"name": "intermediate filament proteins",
"pos": [
22,
52
]
} | {
"id": "C0042666",
"name": "vimentin",
"pos": [
53,
61
]
} |
autoantibodies to the intermediate filament proteins vimentin and keratin were studied in sera of 50 caribbean patients with schistosoma mansoni infection and 50 control subjects . | NA | {
"id": "C0021769",
"name": "intermediate filament proteins",
"pos": [
22,
52
]
} | {
"id": "C0010803",
"name": "keratin",
"pos": [
66,
73
]
} |
the potential role of substance abuse , especially cocaine and alcohol as co-factor in hiv infection and in the development and expression of aids has been suggested , but the possible biological role of substance abuse in the development of aids is not known . | NA | {
"id": "C0019693",
"name": "hiv infection",
"pos": [
87,
100
]
} | {
"id": "C0001175",
"name": "aids",
"pos": [
242,
246
]
} |
higher heparan sulphate labelling was observed in the cytoplasmic and pericellular gags of hm cultures . | NA | {
"id": "C0019143",
"name": "heparan sulphate",
"pos": [
7,
23
]
} | {
"id": "C0017973",
"name": "gags",
"pos": [
83,
87
]
} |
a significant increase in the volume of distribution of drugs such as the aminoglycosides ( gentamicin , amikacin , tobramycin ) , which are highly distributed into the extracellular fluid space and minimally biotransformed , may be anticipated in patients with chronic spinal cord injury . | NA | {
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
74,
89
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
92,
102
]
} |
adverse effects were qualitatively and quantitatively greater during activated charcoal in sorbitol , and the volunteers preferred whole-bowel irrigation over charcoal in sorbitol . | NA | {
"id": "C0001275",
"name": "activated charcoal",
"pos": [
69,
87
]
} | {
"id": "C0007955",
"name": "charcoal",
"pos": [
159,
167
]
} |
a new , rapid dose-induction procedure was used in the evaluation of buprenorphine hydrochloride ( buprenorphine ) as a treatment for opiate dependence . | NA | {
"id": "C0701445",
"name": "buprenorphine hydrochloride",
"pos": [
69,
96
]
} | {
"id": "C0006405",
"name": "buprenorphine",
"pos": [
99,
112
]
} |
vitellogenin purified from the plasma of laying hens is a metalloprotein which upon analysis was found to contain 0.54 , 0.09 and 0.72 micrograms of zinc , copper and iron , respectively , per mg of protein . | NA | {
"id": "C0025544",
"name": "metalloprotein",
"pos": [
58,
72
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
199,
206
]
} |
two apob components of mr corresponding to human apob-100 and one apob-48-like component were represented in vldl fraction . | NA | {
"id": "C0003593",
"name": "apob",
"pos": [
4,
8
]
} | {
"id": "C0205666",
"name": "apob-100",
"pos": [
49,
57
]
} |
two apob components of mr corresponding to human apob-100 and one apob-48-like component were represented in vldl fraction . | NA | {
"id": "C0003593",
"name": "apob",
"pos": [
4,
8
]
} | {
"id": "C0103839",
"name": "apob-48",
"pos": [
66,
73
]
} |
gel electrophoresis of purified total rna revealed comigration of ribosomal rnas ( rrna ) of the myxamoebae with those of mouse kidney and liver , and diploid cells of p. flavicomum . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
38,
41
]
} | {
"id": "C0035701",
"name": "ribosomal rnas",
"pos": [
66,
80
]
} |
total rna from amoebae of a recent isolate of acanthamoeba sp . quantitatively exhibited the same unusual pattern of rrna distribution as the physarum myxamoebae . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
6,
9
]
} | {
"id": "C0035701",
"name": "rrna",
"pos": [
117,
121
]
} |
these results provide evidence for a progressive change in membrane protein organization during erythrocyte aging , enhancing the availability of membrane proteins for interactions with external factors . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
68,
75
]
} | {
"id": "C0025252",
"name": "membrane proteins",
"pos": [
146,
163
]
} |
the results show significant cross-hybridization of the creatine kinase , muscle ( ckmm ) probe to the previously mapped creatine kinase , brain ( ckbb ) locus at 20q13 -- -- qter , and therefore provide independent support for the localization of ckbb at that site . | NA | {
"id": "C0010287",
"name": "creatine",
"pos": [
56,
64
]
} | {
"id": "C0010291",
"name": "muscle",
"pos": [
74,
80
]
} |
the results show that there are no significant differences in clinical effects between aes and placebo in pediatric epilepsies as a whole , but aes is effective in tonic-clonic seizures ( p less than 0.05 ) , the most common type of seizure in the series . | NA | {
"id": "C0014544",
"name": "epilepsies",
"pos": [
116,
126
]
} | {
"id": "C0036572",
"name": "seizure",
"pos": [
233,
240
]
} |
its another equally important advantage is the possibility to restore physiological curvatures of the spine and removal of gibbus . | NA | {
"id": "C0037932",
"name": "curvatures of",
"pos": [
84,
97
]
} | {
"id": "C0022821",
"name": "gibbus",
"pos": [
123,
129
]
} |
epitopes restricted to proteins from th-forming spermatocytes reacted with lectin con a ( specific for d-man and/or d-glc ) and antibodies directed against mouse immunoglobulins ( aia ) . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
23,
31
]
} | {
"id": "C0023206",
"name": "lectin",
"pos": [
75,
81
]
} |
the dnas were transferred to nitrocellulose filters and hybridized with cloned fragments containing sequences of xenopus laevis 28s and 18s ribosomal dna ( rdna ) . | NA | {
"id": "C0012854",
"name": "dnas",
"pos": [
4,
8
]
} | {
"id": "C0012933",
"name": "ribosomal dna",
"pos": [
140,
153
]
} |
observations on sections of human gallstone with electron microscope and analysis of glycoprotein extracted from the stone for amino acids and sulfuric rachiles radicals demonstrated that it was sulphatized glycoprotein and that the fibrous strauds of protein might be precollange-collagenic polypeptide . | NA | {
"id": "C0008350",
"name": "gallstone",
"pos": [
34,
43
]
} | {
"id": "C0006736",
"name": "stone",
"pos": [
117,
122
]
} |
the opioid antagonists , naloxone ( nox ) and naltrexone ( ntx ) , were found to produce dose-dependent increases in fetal mean arterial pressure over a dose range of 5-80 mg/kg . | NA | {
"id": "C0027358",
"name": "naloxone",
"pos": [
25,
33
]
} | {
"id": "C0027360",
"name": "naltrexone",
"pos": [
46,
56
]
} |
above this dose , nox and ntx caused an increase in heart rate as well as blood pressure . | NA | {
"id": "C0027358",
"name": "nox",
"pos": [
18,
21
]
} | {
"id": "C0027360",
"name": "ntx",
"pos": [
26,
29
]
} |
the partial antagonist , levallorphan ( lvl ) , produced effects which were qualitatively similar to those produced by nox and ntx in doses up to 20 mg/kg . | NA | {
"id": "C0027358",
"name": "nox",
"pos": [
119,
122
]
} | {
"id": "C0027360",
"name": "ntx",
"pos": [
127,
130
]
} |
the study utilized cytologic material from ten pleomorphic adenomas , six normal salivary glands , three cases of chronic sialadenitis , three warthin 's tumors , two adenoid cystic carcinomas , three adenocarcinomas , two malignant mixed tumors , one acinic cell carcinoma , and three mucoepidermoid carcinomas . | NA | {
"id": "C0010606",
"name": "adenoid cystic carcinomas",
"pos": [
167,
192
]
} | {
"id": "C0001418",
"name": "adenocarcinomas",
"pos": [
201,
216
]
} |
the study utilized cytologic material from ten pleomorphic adenomas , six normal salivary glands , three cases of chronic sialadenitis , three warthin 's tumors , two adenoid cystic carcinomas , three adenocarcinomas , two malignant mixed tumors , one acinic cell carcinoma , and three mucoepidermoid carcinomas . | NA | {
"id": "C0001418",
"name": "adenocarcinomas",
"pos": [
201,
216
]
} | {
"id": "C0206694",
"name": "mucoepidermoid carcinomas",
"pos": [
286,
311
]
} |
of the positive cases , 83 were metastatic tumors , and 11 were malignant lymphomas ( two non-hodgkin 's lymphomas and nine hodgkin 's lymphomas ) . | NA | {
"id": "C0024299",
"name": "malignant lymphomas",
"pos": [
64,
83
]
} | {
"id": "C0024305",
"name": "non-hodgkin 's",
"pos": [
90,
104
]
} |
of the positive cases , 83 were metastatic tumors , and 11 were malignant lymphomas ( two non-hodgkin 's lymphomas and nine hodgkin 's lymphomas ) . | NA | {
"id": "C0024299",
"name": "malignant lymphomas",
"pos": [
64,
83
]
} | {
"id": "C0019829",
"name": "hodgkin 's lymphomas",
"pos": [
124,
144
]
} |
thoracic trauma is present in 50 % of all trauma patients and is the cause of death in 25 % of these victims . | NA | {
"id": "C0039980",
"name": "thoracic trauma",
"pos": [
0,
15
]
} | {
"id": "C0043251",
"name": "trauma",
"pos": [
42,
48
]
} |
the microsomal fraction prepared from the ah22/pa alpha 1 cells showed 17 alpha-hydroxylase activity toward progesterone and pregnenolone to higher extents , and exhibited c17,20-lyase activity toward 17 alpha-hydroxypregnenolone to a lesser extent and almost no c17,20-lyase activity toward 17 alpha-hydroxyprogesterone... | NA | {
"id": "C0373704",
"name": "pregnenolone",
"pos": [
125,
137
]
} | {
"id": "C0376260",
"name": "17 alpha-hydroxypregnenolone",
"pos": [
201,
229
]
} |
histologically , this tumor is divided into four subtypes : adenoma , pleomorphic adenoma , adenocarcinoma and adenoid cystic carcinoma . | NA | {
"id": "C0001430",
"name": "adenoma",
"pos": [
60,
67
]
} | {
"id": "C0026277",
"name": "pleomorphic adenoma",
"pos": [
70,
89
]
} |
histologically , this tumor is divided into four subtypes : adenoma , pleomorphic adenoma , adenocarcinoma and adenoid cystic carcinoma . | NA | {
"id": "C0001418",
"name": "adenocarcinoma",
"pos": [
92,
106
]
} | {
"id": "C0010606",
"name": "adenoid cystic carcinoma",
"pos": [
111,
135
]
} |
we report here a new formula for estimating apolipoprotein ( apo ) b concentration in the low-density lipoprotein ( ldl ) fraction from measurements of plasma triglyceride and apob . | NA | {
"id": "C0003591",
"name": "apolipoprotein",
"pos": [
44,
58
]
} | {
"id": "C0003593",
"name": "apob",
"pos": [
176,
180
]
} |
this kempen zone is polluted with heavy metals , especially cadmium ( cd ) and zinc ( zn ) , emitted from metal factories in the netherlands and in belgium . | NA | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
34,
46
]
} | {
"id": "C0006632",
"name": "cadmium",
"pos": [
60,
67
]
} |
this kempen zone is polluted with heavy metals , especially cadmium ( cd ) and zinc ( zn ) , emitted from metal factories in the netherlands and in belgium . | NA | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
34,
46
]
} | {
"id": "C0043481",
"name": "zinc",
"pos": [
79,
83
]
} |
the approach is illustrated by the design of cyclic enkephalin-agonist analogues with exceptional delta-opioid-receptor selectivity , and of constrained somatostatin analogues that have become opioid peptides and possess potent opioid antagonist activities and exceptional selectivity for mu-opioid receptors . | NA | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
52,
62
]
} | {
"id": "C0205753",
"name": "opioid",
"pos": [
292,
298
]
} |
nevertheless , spontaneous models of epilepsy are the most commonly used , and chemically or electrically induced seizures in rodents can also identify potential anticonvulsants . | NA | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
37,
45
]
} | {
"id": "C0036572",
"name": "seizures",
"pos": [
114,
122
]
} |
a finding of no significant difference in seizure incidence and/or severity among groups of epileptic patients prospectively randomized to treatment with either a standard or experimental antiepileptic drug is often advanced as compelling proof of the latter 's anticonvulsant efficacy . | NA | {
"id": "C0036572",
"name": "seizure",
"pos": [
42,
49
]
} | {
"id": "C0014544",
"name": "epileptic",
"pos": [
192,
201
]
} |
jme is characterized by myoclonic seizures alone or combined with generalized tonic-clonic seizures or absence seizures . | NA | {
"id": "C0270853",
"name": "jme",
"pos": [
0,
3
]
} | {
"id": "C0014550",
"name": "myoclonic seizures",
"pos": [
24,
42
]
} |
the incidence of genetic variants was much higher in liver ( 5.3 % ) than in brains ( 0.0 % ) , and higher in solubilized nuclear proteins ( 5.3 % ) than in structure-bound nuclear proteins ( 2.1 % ) . | NA | {
"id": "C0028589",
"name": "nuclear proteins",
"pos": [
122,
138
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
181,
189
]
} |
in addition to immunoglobulins , some proteins such as albumin , apolipoprotein a-i and a number of unknown proteins were detected in all preparations . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
38,
46
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
55,
62
]
} |
finally , a 44-nucleotide fragment containing the tymv rna pseudoknot and strongly resembling the aminoacyl acceptor arm of the viral rna was also synthesised using t7 rna polymerase . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
55,
58
]
} | {
"id": "C0035736",
"name": "viral rna",
"pos": [
128,
137
]
} |
all single-stranded polydeoxyribonucleotides ( dna ) efficiently stimulated the proteolysis and the maximum activation was reached in the presence of three or four nucleotides of polynucleotide per monomer of reca . | NA | {
"id": "C0032468",
"name": "polydeoxyribonucleotides",
"pos": [
20,
44
]
} | {
"id": "C0032550",
"name": "polynucleotide",
"pos": [
179,
193
]
} |
all single-stranded polydeoxyribonucleotides ( dna ) efficiently stimulated the proteolysis and the maximum activation was reached in the presence of three or four nucleotides of polynucleotide per monomer of reca . | NA | {
"id": "C0028630",
"name": "nucleotides",
"pos": [
33,
44
]
} | {
"id": "C0032550",
"name": "polynucleotide",
"pos": [
179,
193
]
} |
the stimulative effect was decreased in the presence of larger amounts of poly ( da ) , poly ( dt ) or heat-denatured dna , whereas the excess of single-stranded dnas chemically modified with chloroacetaldehyde did not present such an inhibitory effect , despite the fact that a second dna molecule is likely to interact... | NA | {
"id": "C0012935",
"name": "single-stranded dnas",
"pos": [
146,
166
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
383,
386
]
} |
assignments for 1h-nmr resonances of most of the residues of bovine pancreatic ribonuclease ( rnase a ) have been obtained by sequence-specific methods . | NA | {
"id": "C0035541",
"name": "pancreatic",
"pos": [
68,
78
]
} | {
"id": "C0014241",
"name": "rnase",
"pos": [
94,
99
]
} |
the mutase and the isomerase were purified together by chromatography on quaternary-amine-sepharose ( q-sepharose ) and on cyanocobalamin-agarose . | NA | {
"id": "C0524938",
"name": "mutase",
"pos": [
4,
10
]
} | {
"id": "C0022202",
"name": "isomerase",
"pos": [
19,
28
]
} |
both enzymes appear to be homotetramers with subunits of 70 kda ( mutase ) and 50 kda ( isomerase ) . | NA | {
"id": "C0524938",
"name": "mutase",
"pos": [
66,
72
]
} | {
"id": "C0022202",
"name": "isomerase",
"pos": [
88,
97
]
} |
in gp65 , however , asparagine residue 11 is almost exclusively substituted by complete , fucosylated n-acetyllactosaminic oligosaccharides , whereas asparagine residue 26 carries oligomannosidic or truncated n-acetyllactosaminic glycans . | NA | {
"id": "C0028959",
"name": "oligosaccharides",
"pos": [
123,
139
]
} | {
"id": "C0032594",
"name": "glycans",
"pos": [
230,
237
]
} |
terbium ions and terbium formycin triphosphate have been used to investigate the interactions between the cation and nucleotide binding sites of the sarcoplasmic reticulum ca2+-atpase . | NA | {
"id": "C0022023",
"name": "ions",
"pos": [
8,
12
]
} | {
"id": "C0007447",
"name": "cation",
"pos": [
106,
112
]
} |
two terbium ions , at least , bind to the ca2+-atpase in the close vicinity of ftp when this nucleotide is bound to the atpase nucleotide site . | NA | {
"id": "C0001476",
"name": "ca2",
"pos": [
42,
45
]
} | {
"id": "C0001473",
"name": "atpase",
"pos": [
120,
126
]
} |
three representative amino acids , glutamate , aspartate and alanine were isolated from cells after growth for several generations in the presence of [ 1,4-13c2 ] succinate and their labelling patterns were determined by 13c nmr spectroscopy . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
21,
32
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
61,
68
]
} |
( a ) the secretory protein invertase was oligomerized and extensively glycosylated , ( b ) the n-glycan cores of bulk-cell surface mannans were extended with outer chains , ( c ) some n-glycans were phosphorylated , ( d ) the protein-bound o-glycans were extended up to tetramannosides , ( e ) prepro-ka-factor was prot... | NA | {
"id": "C0024727",
"name": "mannans",
"pos": [
132,
139
]
} | {
"id": "C0032594",
"name": "glycans",
"pos": [
243,
250
]
} |
although acetyl-coa hydrolase was relatively specific for acetyl-coa , longer acyl-chain coas were also hydrolyzed and were capable of functioning as inhibitors during the hydrolysis of acetyl-coa . | NA | {
"id": "C0001374",
"name": "acyl",
"pos": [
78,
82
]
} | {
"id": "C0001026",
"name": "acetyl-coa",
"pos": [
186,
196
]
} |
the active site of the enzyme was probed by studies of the inhibition by d- and l-beta-aminoglutaryl-l-alanine which are the beta-amino-acid isomers of d- and l-gamma-glutamyl-l-alanine ( the latter being a natural substrate of the enzyme ) ; | NA | {
"id": "C0002520",
"name": "amino-acid",
"pos": [
130,
140
]
} | {
"id": "C0001898",
"name": "l",
"pos": [
213,
214
]
} |
the finding of primarily high avidity antibodies against p24 antigen in patients with more advanced immunodeficiency indicates that a decline of p24 antibodies during the clinical course of hiv infection may not be explained exclusively by an increased production of viral proteins . | NA | {
"id": "C0021051",
"name": "immunodeficiency",
"pos": [
100,
116
]
} | {
"id": "C0019693",
"name": "hiv infection",
"pos": [
190,
203
]
} |
the in vitro and in vivo activity of the new macrolides azithromycin , clarithromycin and roxythromycin was compared with that of erythromycin against borrelia burgdorferi . | NA | {
"id": "C0052796",
"name": "azithromycin",
"pos": [
56,
68
]
} | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
130,
142
]
} |
the in vitro and in vivo activity of the new macrolides azithromycin , clarithromycin and roxythromycin was compared with that of erythromycin against borrelia burgdorferi . | NA | {
"id": "C0055856",
"name": "clarithromycin",
"pos": [
71,
85
]
} | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
130,
142
]
} |
mics and mbcs of four new macrolides ( azithromycin , clarithromycin , dirithromycin and roxithromycin ) and two older macrolides ( erythromycin and josamycin ) for bordetella pertussis and bordetella parapertussis were determined . | NA | {
"id": "C0052796",
"name": "azithromycin",
"pos": [
39,
51
]
} | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
132,
144
]
} |
mics and mbcs of four new macrolides ( azithromycin , clarithromycin , dirithromycin and roxithromycin ) and two older macrolides ( erythromycin and josamycin ) for bordetella pertussis and bordetella parapertussis were determined . | NA | {
"id": "C0055856",
"name": "clarithromycin",
"pos": [
54,
68
]
} | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
132,
144
]
} |
mics and mbcs of four new macrolides ( azithromycin , clarithromycin , dirithromycin and roxithromycin ) and two older macrolides ( erythromycin and josamycin ) for bordetella pertussis and bordetella parapertussis were determined . | NA | {
"id": "C0035891",
"name": "roxithromycin",
"pos": [
89,
102
]
} | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
132,
144
]
} |
our findings indicate that the combination of bmipp and thallium for myocardial imaging supply different information about the zone of infarction and ischemia , which may be useful for the assessment of myocardial viability . | NA | {
"id": "C0021308",
"name": "infarction",
"pos": [
135,
145
]
} | {
"id": "C0022116",
"name": "ischemia",
"pos": [
150,
158
]
} |
apoe was highest in individuals with the epsilon 2 allele and lowest in individuals expressing apoe4 , and vice versa for apob . | NA | {
"id": "C0003595",
"name": "apoe",
"pos": [
0,
4
]
} | {
"id": "C0052201",
"name": "apoe4",
"pos": [
95,
100
]
} |
vldl from both groups of cholesterol-fed animals stimulated cholesteryl ester synthesis in cultured macrophages to the same extent . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
25,
36
]
} | {
"id": "C0008387",
"name": "cholesteryl ester",
"pos": [
60,
77
]
} |
thus , in rabbits under a dietary cholesterol load , oestrogen counteracted hepatic lipoprotein receptor suppression , reduced plasma vldl- and increased plasma hdl-cholesterol levels , and to a large extent abolished the development of atherosclerosis . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
84,
95
]
} | {
"id": "C0023825",
"name": "vldl",
"pos": [
134,
138
]
} |
in the insulin-only experiment , human growth hormone , adrenocorticotrophic hormone , cortisol , aldosterone , plasma renin activity , adrenaline , and noradrenaline were all stimulated by hypoglycaemia . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
136,
146
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
153,
166
]
} |
we have compared in two separate studies the kinetics of ceftriaxone and cefotaxime in 8 cirrhotic patients with ascites and 8 control subjects after a single 20 min intravenous infusion of 1 g of each drug . | NA | {
"id": "C0007561",
"name": "ceftriaxone",
"pos": [
57,
68
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
73,
83
]
} |
the apparent volumes of distribution ( vz ) were found to be significantly higher in cirrhotics than in control subjects ( 0.87 , versus 0.49 , l.kg-1 , for cefotaxime and 0.23 versus 0.13 for ceftriaxone ) . | NA | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
157,
167
]
} | {
"id": "C0007561",
"name": "ceftriaxone",
"pos": [
193,
204
]
} |
in addition , redirected cytolytic activity towards peripheral blood mononuclear cells by reticuloendothelial system cells , resulting from linking these two types of cells through fc-fc receptor interactions , does not occur . | NA | {
"id": "C1321301",
"name": "peripheral blood mononuclear cells",
"pos": [
52,
86
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
167,
172
]
} |
since quail cells are not recognized by our panel of monoclonal antibodies against chicken tcr1 , tcr2 , tcr3 , cd3 , cd4 and cd8 molecules , these antibodies provided reliable markers for donor chick lymphocytes in the tissues of the quail recipients . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
53,
74
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
148,
158
]
} |
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