text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
in this latter case the absence of detectable specific antibody response , whether of ige or igg isotype , suggested that parasites were destroyed by an antibody-independent mechanism , i.e . macrophages activation by lymphokines . | NA | {
"id": "C0021017",
"name": "isotype",
"pos": [
97,
104
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
153,
161
]
} |
however , mab 89 does not prepare b cells to respond to the growth-promoting activity of interleukin ( il ) 2 or il 4 . | NA | {
"id": "C0021764",
"name": "interleukin",
"pos": [
89,
100
]
} | {
"id": "C0021758",
"name": "il 4",
"pos": [
113,
117
]
} |
in the splanchnic artery occlusion shock + sk & f 104353 group the increase in the plasma activities of the lysosomal hydrolase , cathepsin d , and the cardiotoxic peptide , myocardial depressant factor , were significantly attenuated in comparison to the splanchnic artery occlusion shock + vehicle group ( p less than ... | NA | {
"id": "C0030956",
"name": "peptide",
"pos": [
164,
171
]
} | {
"id": "C0027047",
"name": "myocardial",
"pos": [
174,
184
]
} |
in contrast , nifedipine and methoxyverapamil ( d600 , 0.3-0.8 microm ) blocked only the tonic component of the noradrenaline , adrenaline or phenylephrine-induced contractions . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
112,
125
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
128,
138
]
} |
an-132 was much less potent to depress ik.ach in gtp-gamma s-loaded cells than in gtp-loaded cells . | NA | {
"id": "C0079469",
"name": "gtp-gamma s",
"pos": [
49,
60
]
} | {
"id": "C0018353",
"name": "gtp",
"pos": [
82,
85
]
} |
radioligand binding demonstrated two muscarinic receptor sites in rabbit ganglia , with the characteristics of m1- and m2-receptors . | NA | {
"id": "C0034826",
"name": "binding",
"pos": [
12,
19
]
} | {
"id": "C0384752",
"name": "m2-receptors",
"pos": [
119,
131
]
} |
isotyping of the mc-icsa revealed that 13 of the antibodies belong to the class igm , and 3 to the subclass igg1 . | NA | {
"id": "C0021017",
"name": "isotyping",
"pos": [
0,
9
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
49,
59
]
} |
unexpectedly , no monoclonal antibodies were directed against the endocrine pancreas , whereas six out of seven exocrine reacting antibodies stained total or subpopulations of cells in sections of monoclonal hypoglycemic msl-tumors . | NA | {
"id": "C0003250",
"name": "monoclonal",
"pos": [
18,
28
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
130,
140
]
} |
the effects of glibenclamide and its non-sulfonylurea analogue hb 699 on the sodium content of rat pancreatic islets . | NA | {
"id": "C0017628",
"name": "glibenclamide",
"pos": [
15,
28
]
} | {
"id": "C0038766",
"name": "sulfonylurea",
"pos": [
41,
53
]
} |
the complexity of the glibenclamide action became evident with its reversal after removal of extracellular ca2+ and the observation that the sulfonylurea counteracted the increase of sodium obtained after removal of k+ . | NA | {
"id": "C0017628",
"name": "glibenclamide",
"pos": [
22,
35
]
} | {
"id": "C0038766",
"name": "sulfonylurea",
"pos": [
141,
153
]
} |
the effects of glibenclamide were mimicked by 1 mmol/l of its non-sulfonylurea analogue hb 699 with the exception that the latter compound being without suppressive action on the sodium content in medium deprived of ca2+ . | NA | {
"id": "C0017628",
"name": "glibenclamide",
"pos": [
15,
28
]
} | {
"id": "C0038766",
"name": "sulfonylurea",
"pos": [
66,
78
]
} |
the suppressive activity of sp1 on purified hpc was confirmed when 10 ( -3 ) m sp1 completely inhibited colony and cluster formation from a population of mouse bone marrow cells in which one of two cells was a cfu-gm . | NA | {
"id": "C0018956",
"name": "hpc",
"pos": [
44,
47
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
198,
203
]
} |
the effects of sp1 were not absolutely cell-cycle-specific for human hpc , but the non-s-phase cells were less sensitive than the s-phase cells to the suppressive effects of sp1 . | NA | {
"id": "C0018956",
"name": "hpc",
"pos": [
69,
72
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
138,
143
]
} |
thus the new data on stem cell behavior during tap treatment support the hypothesis of a feedback from erythroid and granuloid precursors to the stem cells . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
5,
8
]
} | {
"id": "C0018956",
"name": "precursors",
"pos": [
127,
137
]
} |
on the other hand , wsp mice , genetically susceptible to the development of severe ethanol withdrawal , show a similar predisposition to diazepam and phenobarbital withdrawal , which suggests that there may be a common set of genes underlying drug dependencies . | NA | {
"id": "C0314657",
"name": "genetically susceptible",
"pos": [
31,
54
]
} | {
"id": "C0012655",
"name": "predisposition",
"pos": [
120,
134
]
} |
the vitamin a immunoreaction of the outer segments suggests retinoids are present as chromophores of the photopigments . | NA | {
"id": "C0042839",
"name": "vitamin a",
"pos": [
4,
13
]
} | {
"id": "C0035339",
"name": "retinoids",
"pos": [
60,
69
]
} |
neutralizing monoclonal antibody specific for alpha-bungarotoxin : preparation and characterization of the antibody , and localization of antigenic region of alpha-bungarotoxin . | NA | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
13,
32
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
107,
115
]
} |
to evaluate the effects of cc on the timing of the luteinizing hormone ( lh ) surge , we examined the lh surge in 10 cycling normal women for 3 cycles each , during an untreated cycle ( control ) and during treatment with 50 mg cc ( cc 50 ) and 150 mg cc ( cc 150 ) daily on days 5 to 9 . | NA | {
"id": "C0009008",
"name": "cc",
"pos": [
27,
29
]
} | {
"id": "C0546859",
"name": "cc",
"pos": [
257,
259
]
} |
selective fetal reduction was performed in the first trimester of pregnancy in 20 women with multifetal gestations after ovulation induction with human menopausal gonadotropin ( hmg ) . | NA | {
"id": "C0032979",
"name": "first trimester",
"pos": [
47,
62
]
} | {
"id": "C0032961",
"name": "gestations",
"pos": [
104,
114
]
} |
using ascites tumour cells ( ehrlich carcinoma , plasmacytoma mops-21 , leukaemia p-388 , lympholeukaemia nk/ly ) and bone marrow cells from normal rats , we have demonstrated that transcription of a gene coding for the 35s rna can be regulated via alteration of the na+/k+ ratio in the cells . | NA | {
"id": "C0007125",
"name": "ascites tumour",
"pos": [
6,
20
]
} | {
"id": "C0007097",
"name": "carcinoma",
"pos": [
37,
46
]
} |
data demonstrate : ( a ) normal fibroblasts enhance the outgrowth and induce a more organized phenotype in squamous cell carcinoma cells ; | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
32,
43
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
131,
136
]
} |
cellular lectins ( cls ) of phallusia mamillata were demonstrated in protein preparations obtained by salt fractionation from hemocytes sonicated in a suitable medium . | NA | {
"id": "C0023206",
"name": "lectins",
"pos": [
9,
16
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
69,
76
]
} |
affinity chromatography on immobilized lectins revealed that the [ 125i ] hgh-receptor complexes were specifically retained and eluted from ricin lectin-agarose , concanavalin a and lentil lectin , indicating the presence of n-linked glycans . | NA | {
"id": "C0036681",
"name": "agarose",
"pos": [
153,
160
]
} | {
"id": "C0032594",
"name": "glycans",
"pos": [
234,
241
]
} |
the expression of the neural adhesion molecules l1 and n-cam has been studied in the embryonic and early postnatal olfactory system of the mouse in order to gain insight into the function of these molecules during development of a neural structure which retains neuronal turnover capacities throughout adulthood . | NA | {
"id": "C0950625",
"name": "neural adhesion molecules l1",
"pos": [
22,
50
]
} | {
"id": "C0282587",
"name": "n-cam",
"pos": [
55,
60
]
} |
a library of monoclonal antibodies specific for myosin heavy chain ( hc ) was used to study myosin expression in regenerating fibers . | NA | {
"id": "C0027100",
"name": "myosin heavy chain",
"pos": [
48,
66
]
} | {
"id": "C0027096",
"name": "myosin",
"pos": [
92,
98
]
} |
two of the cells discussed here , the neurons nz4 and mz3 , stain with antibodies to the neuropeptides scp and fmrfamide during the course of their embryonic differentiation , but only a subset of the initially immunoreactive homologs continue to express this immunoreactivity into postembryonic life . | NA | {
"id": "C0027895",
"name": "neuropeptides",
"pos": [
89,
102
]
} | {
"id": "C0060608",
"name": "fmrfamide",
"pos": [
111,
120
]
} |
to address this question , we have compared the effect of 6 months of insulin therapy twice daily with that of a combination of glibenclamide and metformin in 24 type 2 diabetic subjects , who no longer responded to treatment with sulfonylureas . | NA | {
"id": "C0017628",
"name": "glibenclamide",
"pos": [
128,
141
]
} | {
"id": "C0038766",
"name": "sulfonylureas",
"pos": [
231,
244
]
} |
monovalent antibodies prepared from rabbit antiserum against fusion-competent nc4 cells inhibit the sexual cell fusion of these cells completely . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
11,
21
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
43,
52
]
} |
it turned out that tp1 is a small , but very basic protein with 54 amino acids ( 21 % arginine , 19 % lysine ) and is highly conserved during mammalian evolution at the nucleotide as well as at the amino-acid level . | NA | {
"id": "C0301714",
"name": "basic",
"pos": [
45,
50
]
} | {
"id": "C0003765",
"name": "arginine",
"pos": [
86,
94
]
} |
it turned out that tp1 is a small , but very basic protein with 54 amino acids ( 21 % arginine , 19 % lysine ) and is highly conserved during mammalian evolution at the nucleotide as well as at the amino-acid level . | NA | {
"id": "C0301714",
"name": "basic",
"pos": [
45,
50
]
} | {
"id": "C0024337",
"name": "lysine",
"pos": [
102,
108
]
} |
it turned out that tp1 is a small , but very basic protein with 54 amino acids ( 21 % arginine , 19 % lysine ) and is highly conserved during mammalian evolution at the nucleotide as well as at the amino-acid level . | NA | {
"id": "C0301714",
"name": "basic",
"pos": [
45,
50
]
} | {
"id": "C0002520",
"name": "amino-acid",
"pos": [
198,
208
]
} |
distribution of intermediate-filament proteins in the human enamel organ : unusually complex pattern of coexpression of cytokeratin polypeptides and vimentin . | NA | {
"id": "C0021769",
"name": "intermediate-filament proteins",
"pos": [
16,
46
]
} | {
"id": "C0010803",
"name": "cytokeratin",
"pos": [
120,
131
]
} |
distribution of intermediate-filament proteins in the human enamel organ : unusually complex pattern of coexpression of cytokeratin polypeptides and vimentin . | NA | {
"id": "C0021769",
"name": "intermediate-filament proteins",
"pos": [
16,
46
]
} | {
"id": "C0042666",
"name": "vimentin",
"pos": [
149,
157
]
} |
work summarized here demonstrates that the relative contributions of glucose carbon to hepatic glycogen formation by the indirect and direct pathways are greatly dependent on experimental design , and at least in vitro , are possibly dependent on the extent of glycogen/glucose 1-p recycling . | NA | {
"id": "C0023902",
"name": "hepatic glycogen",
"pos": [
87,
103
]
} | {
"id": "C0017911",
"name": "glycogen",
"pos": [
261,
269
]
} |
angiomyolipoma is one of the benign hamartomas arising principally in the kidneys of patients with or without tuberous sclerosis . | NA | {
"id": "C0018552",
"name": "hamartomas",
"pos": [
36,
46
]
} | {
"id": "C0041341",
"name": "tuberous sclerosis",
"pos": [
110,
128
]
} |
lactose is not digested completely when intestinal lactase activity is low and the disaccharide is malabsorbed . | NA | {
"id": "C0022949",
"name": "lactose",
"pos": [
0,
7
]
} | {
"id": "C0012611",
"name": "disaccharide",
"pos": [
83,
95
]
} |
the 14 subjects who did not malabsorb lactose by breath hydrogen testing ( defined as a rise in the breath hydrogen concentration of less than or equal to 20 parts per million above the baseline value ) , had significantly more galactose in their urine 1 , 2 , and 3 h after lactose ingestion than lactose malabsorbers . | NA | {
"id": "C0020275",
"name": "hydrogen",
"pos": [
56,
64
]
} | {
"id": "C0041119",
"name": "3 h",
"pos": [
265,
268
]
} |
a lipid component was isolated from the fatty acid fraction of acid hydrolysates of lipid a derived from pseudomonas diminuta jcm 2788 and pseudomonas vesicularis jcm 1477 lipopolysaccharides . | NA | {
"id": "C0023767",
"name": "lipid a",
"pos": [
84,
91
]
} | {
"id": "C0023810",
"name": "lipopolysaccharides",
"pos": [
172,
191
]
} |
the sequences of a 51-kb region containing the cluster of five rat gamma-crystallin-coding genes ( cryg ) and of a 7-kb region surrounding the sixth rat cryg gene were determined . | NA | {
"id": "C0017030",
"name": "gamma-crystallin",
"pos": [
67,
83
]
} | {
"id": "C0010422",
"name": "cryg",
"pos": [
153,
157
]
} |
the complete sequence of the rabbit erythroid cell-specific 15-lipoxygenase mrna : comparison of the predicted amino acid sequence of the erythrocyte lipoxygenase with other lipoxygenases . | NA | {
"id": "C0023837",
"name": "lipoxygenase",
"pos": [
63,
75
]
} | {
"id": "C2936592",
"name": "lipoxygenases",
"pos": [
174,
187
]
} |
the prognostic value of progesterone ( p ) , androstenedione ( a ) , estradiol , testosterone , 20 alpha-hydroxy-progesterone , sex hormone binding globulin , and albumin ( alb ) was investigated in 51 women with ovarian carcinoma . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
24,
36
]
} | {
"id": "C0012311",
"name": "20 alpha-hydroxy-progesterone",
"pos": [
96,
125
]
} |
plasma concentrations of thyroxine ( t4 ) and thyroxine-binding globulin ( tbg ) as well as triiodothyronine uptake ( t3u ) were measured in 32 proteinuric pre-eclamptic patients and 24 normotensive pregnant women at similar gestations in the third trimester . | NA | {
"id": "C0032961",
"name": "gestations",
"pos": [
225,
235
]
} | {
"id": "C0032981",
"name": "third trimester",
"pos": [
243,
258
]
} |
genotoxic testing of flavonol glycosides , which account for most of the human intake of flavonoids , is dependent on the use of enzymatic extracts that exhibit beta-glycosidic activity . | NA | {
"id": "C0060444",
"name": "flavonol",
"pos": [
21,
29
]
} | {
"id": "C0596577",
"name": "flavonoids",
"pos": [
89,
99
]
} |
our data show that patients with graves ' hyperthyroidism manifest glucose intolerance , hyperinsulinemia and insulin resistance . | NA | {
"id": "C0020459",
"name": "hyperinsulinemia",
"pos": [
89,
105
]
} | {
"id": "C0021655",
"name": "insulin resistance",
"pos": [
110,
128
]
} |
on cultured zajdela hepatoma cells ( zhc cells ) , p95 ab also mimicked insulin action on the incorporation of [ u-14c ] glucose into glycogen ( 158 and 207 % of the control value for antibody- and insulin-treated cells , respectively ) . | NA | {
"id": "C0021644",
"name": "ab",
"pos": [
55,
57
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
184,
192
]
} |
effects of opioid peptides ( beta-endorphin , dynorphin ( 1-13 ) . alpha-neoendorphin , beta-neoendorphin , leucine-enkephalin , methionine-enkephalin ) on the release of thyrotropin-releasing hormone ( trh ) from the rat caecum were studied in vitro . | NA | {
"id": "C0205753",
"name": "opioid peptides",
"pos": [
11,
26
]
} | {
"id": "C0013355",
"name": "dynorphin",
"pos": [
46,
55
]
} |
in control rats the urea synthesis exceeded the alanine infusion by indicating an extrahepatic tissue release of amino acids . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
48,
55
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
113,
124
]
} |
the pituitary-thyroid axis of 12 patients , exposed to transsphenoidal pituitary microsurgery because of nonfunctioning adenomas ( 6 ) , prolactinomas ( 3 ) and craniopharyngioma ( 1 ) , or to major pituitary injury ( 1 apoplexy , 1 accidental injury ) , was controlled more than 6 months following the incidents . | NA | {
"id": "C0001430",
"name": "adenomas",
"pos": [
120,
128
]
} | {
"id": "C0033375",
"name": "prolactinomas",
"pos": [
137,
150
]
} |
na+ , k+-atpase , a marker enzyme for the basolateral domain , was enriched 28.9-fold in the final membrane fraction compared with homogenate , whereas the bile canalicular membrane enzymes mg++-atpase and alkaline phosphatase were enriched only 3.4- and 6.4-fold , respectively . | NA | {
"id": "C0001479",
"name": "na",
"pos": [
0,
2
]
} | {
"id": "C0001473",
"name": "atpase",
"pos": [
195,
201
]
} |
chloride as the accompanying anion stimulated the initial rate of uptake compared with anions of lesser or greater lipid permeability . | NA | {
"id": "C0008203",
"name": "chloride",
"pos": [
0,
8
]
} | {
"id": "C0003075",
"name": "anions",
"pos": [
87,
93
]
} |
deoxycholic acid was the most effective , chenodeoxycholic acid was less effective and ursodeoxycholic acid was ineffective in the concentrations used . | NA | {
"id": "C0011479",
"name": "deoxycholic acid",
"pos": [
0,
16
]
} | {
"id": "C0008024",
"name": "chenodeoxycholic acid",
"pos": [
42,
63
]
} |
deoxycholic acid was the most effective , chenodeoxycholic acid was less effective and ursodeoxycholic acid was ineffective in the concentrations used . | NA | {
"id": "C0011479",
"name": "deoxycholic acid",
"pos": [
0,
16
]
} | {
"id": "C0042105",
"name": "ursodeoxycholic acid",
"pos": [
87,
107
]
} |
lymphocyte and fibroblast cultures from the most severely affected sib , the proband , contained the highest percentage of cells with ring ( 20 ) chromosome and revealed the greatest instability of the ring . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
15,
25
]
} | {
"id": "C0007634",
"name": "the",
"pos": [
198,
201
]
} |
toluene and the chlorinated hydrocarbons 1,1,1-trichloroethane and trichloroethylene can cause permanent damage to the kidney , liver , heart and lung , in certain volatile substance abusers . | NA | {
"id": "C0020247",
"name": "chlorinated hydrocarbons",
"pos": [
16,
40
]
} | {
"id": "C0040904",
"name": "trichloroethane",
"pos": [
47,
62
]
} |
toluene and the chlorinated hydrocarbons 1,1,1-trichloroethane and trichloroethylene can cause permanent damage to the kidney , liver , heart and lung , in certain volatile substance abusers . | NA | {
"id": "C0020247",
"name": "chlorinated hydrocarbons",
"pos": [
16,
40
]
} | {
"id": "C0040905",
"name": "trichloroethylene",
"pos": [
67,
84
]
} |
a human okt8-positive t cell hybridoma was established by using concanavalin a ( cona ) -activated peripheral blood mononuclear cells ( pbmc ) fused with cem-agr cells . | NA | {
"id": "C1321301",
"name": "peripheral blood mononuclear cells",
"pos": [
99,
133
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
162,
167
]
} |
in immunoblotting experiments a binding could be demonstrated , for most antibodies , to two thermostable proteins with apparent molecular weights of 20.6/20.8 kd for g. rostochiensis and 20.5/21.0 kd for g. pallida . the reactivity of the monoclonal antibodies with thermostable protein antigens from other common cyst ... | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
73,
83
]
} | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
240,
261
]
} |
the antibodies are both of igg isotype and bind to their target antigens with affinities in excess of 10 ( -9 ) m . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
4,
14
]
} | {
"id": "C0021017",
"name": "isotype",
"pos": [
31,
38
]
} |
thirty-five patients of chronic stable angina , unstable angina and post mi angina , who were on medical treatment , underwent 24 hours holter monitoring and coronary angiography to find out the incidence of silent myocardial ischemia ( smi ) and its relation to anatomic severity of coronary artery disease . | NA | {
"id": "C0340288",
"name": "chronic stable angina",
"pos": [
24,
45
]
} | {
"id": "C0002962",
"name": "angina",
"pos": [
76,
82
]
} |
thirty-five patients of chronic stable angina , unstable angina and post mi angina , who were on medical treatment , underwent 24 hours holter monitoring and coronary angiography to find out the incidence of silent myocardial ischemia ( smi ) and its relation to anatomic severity of coronary artery disease . | NA | {
"id": "C0002965",
"name": "unstable angina",
"pos": [
48,
63
]
} | {
"id": "C0002962",
"name": "angina",
"pos": [
76,
82
]
} |
transposition of great arteries ( ps ) , tricuspid atresia with vsd , ps and double outlet right ventricle with vsd comprised 25 % of the cardiac lesions . | NA | {
"id": "C0040761",
"name": "transposition of great arteries",
"pos": [
0,
31
]
} | {
"id": "C0013069",
"name": "double outlet right ventricle",
"pos": [
77,
106
]
} |
the binding of antitumour drug mitoxantrone [ 1,4-dihydroxy-5 , 8-bis [ 2- ( 2-hydroxy ethyl ) amino ) ethyl ) amino ) -9 , 10-anthracenedione ] to the synthetic polynucleotide poly [ d ( g-c ) ] was studied by circular dichroic titrations . | NA | {
"id": "C0026259",
"name": "mitoxantrone",
"pos": [
31,
43
]
} | {
"id": "C0003174",
"name": "anthracenedione",
"pos": [
127,
142
]
} |
the latter three phosphoproteins were found to be unlabelled after pha pretreatment , but upon il-2 stimulation the 94-kda and the 85-kda proteins became labelled simultaneously with two minor phosphoproteins of 68 kda ( pi 5.7 ) and 37 kda ( pi 4.8 ) . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
24,
32
]
} | {
"id": "C0031689",
"name": "phosphoproteins",
"pos": [
193,
208
]
} |
the data indicate that the antiserum prepared against the enterotoxin of ct+ strain contains antibody against the nct and can neutralise the toxin in vivo . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
27,
36
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
93,
101
]
} |
the data indicate that the antiserum prepared against the enterotoxin of ct+ strain contains antibody against the nct and can neutralise the toxin in vivo . | NA | {
"id": "C0014372",
"name": "enterotoxin",
"pos": [
58,
69
]
} | {
"id": "C0040549",
"name": "toxin",
"pos": [
141,
146
]
} |
540 strains of bacteria isolated from various clinical materials comprising 440 strains of gram negative bacilli and 100 strains of gram positive cocci were tested for their susceptibility in vitro to kanamycin , gentamicin and a new aminoglycoside antibiotic sisomicin ( ensamycin ) . | NA | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
213,
223
]
} | {
"id": "C0037209",
"name": "sisomicin",
"pos": [
260,
269
]
} |
the sensitivity pattern revealed that 68.88 % of the strains were sensitive to kanamycin , 82.9 % to gentamicin and 89.0 % to sisomicin . | NA | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
101,
111
]
} | {
"id": "C0037209",
"name": "sisomicin",
"pos": [
126,
135
]
} |
in particular a considerable number of gentamicin resistant pseudomonas aeruginosa ( 12.3 % ) were found to be sensitive to sisomicin which is a highly desirable property . | NA | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
39,
49
]
} | {
"id": "C0037209",
"name": "sisomicin",
"pos": [
124,
133
]
} |
the absence of a band recognized by antibodies in the absorbed antiserum compared with the unabsorbed antiserum indicated that surface-exposed determinants of the absorbing strain cross-reacted with determinants on the homologous strain . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
36,
46
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
102,
111
]
} |
analysis of bacterial surface proteins suggested that the genes marked by these fusions may play a role in the correct surface expression of the ipab and ipac gene products . | NA | {
"id": "C0004627",
"name": "bacterial",
"pos": [
12,
21
]
} | {
"id": "C0033684",
"name": "gene",
"pos": [
159,
163
]
} |
bolus injection of lethal or sublethal doses of endotoxin or lipopolysaccharide ( lps ) results in the rapid and transient rise in tumor necrosis factor ( tnf ) levels in serum in mammals . | NA | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
48,
57
]
} | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
61,
79
]
} |
the beneficial effect of hril-2 was observed with as little as 0.6 micrograms per mouse , whereas optimum protection occurred at 6 micrograms per mouse , hril-2 was equally protective when administered concomitant with the listeriae or up to 24 h prior to infection ; | NA | {
"id": "C0218986",
"name": "hril-2",
"pos": [
25,
31
]
} | {
"id": "C0021756",
"name": "hril-2",
"pos": [
154,
160
]
} |
administration of hril-2 to uninfected mice had no effect on spleen cell proliferation in response to mitogens in vitro , nor did hril-2 treatment restore normal levels of splenocyte proliferative responses to listeria-infected mice . | NA | {
"id": "C0218986",
"name": "hril-2",
"pos": [
18,
24
]
} | {
"id": "C0021756",
"name": "hril-2",
"pos": [
130,
136
]
} |
the genetic and antigenic relatedness of eight antigens in three strains of rickettsia tsutsugamushi has been studied by using recombinant organisms expressing epitopes of the 150- , 110- , 72- , 58- , 56- , 49- , 47- , and 20-kilodalton ( kda ) polypeptide antigens of the karp strain . | NA | {
"id": "C0003316",
"name": "epitopes",
"pos": [
160,
168
]
} | {
"id": "C0003320",
"name": "antigens",
"pos": [
258,
266
]
} |
additional analysis indicated that the 110-kda antigen may contain strain-specific epitopes similar to those previously reported for the 56-kda polypeptide . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
47,
54
]
} | {
"id": "C0003316",
"name": "epitopes",
"pos": [
83,
91
]
} |
monoclonal antibodies have been generated to the unique distal sugar epitopes on the oligosaccharide haptens of the glycopeptidolipid antigens of clinically prominent members of the mycobacterium avium serocomplex . | NA | {
"id": "C0003316",
"name": "epitopes",
"pos": [
69,
77
]
} | {
"id": "C0018593",
"name": "haptens",
"pos": [
101,
108
]
} |
monoclonal antibodies have been generated to the unique distal sugar epitopes on the oligosaccharide haptens of the glycopeptidolipid antigens of clinically prominent members of the mycobacterium avium serocomplex . | NA | {
"id": "C0003316",
"name": "epitopes",
"pos": [
69,
77
]
} | {
"id": "C0003320",
"name": "antigens",
"pos": [
134,
142
]
} |
epitope definition was arrived at through use of the pure , chemically defined glycopeptidolipid antigens and neoglycoproteins containing the chemically synthesized distal sugars of some select serovars . | NA | {
"id": "C0003316",
"name": "epitope",
"pos": [
0,
7
]
} | {
"id": "C0003320",
"name": "antigens",
"pos": [
97,
105
]
} |
incubation of the cells with guanosine 5'-o- ( 3-thiotriphosphate ) the stable analog of gtp , led to a time-dependent increase in leukotriene generation induced by formyl-methionyl-leucyl phenylalanine which was abolished by the simultaneous addition of pertussis toxin . | NA | {
"id": "C0079469",
"name": "guanosine 5",
"pos": [
29,
40
]
} | {
"id": "C0018353",
"name": "gtp",
"pos": [
89,
92
]
} |
a radiometric assay was used to measure ha levels in 35 children with renal tumours [ 33 wilms ' tumours and 2 bone metastasizing renal tumours of childhood ( bmrtc ) ] and 20 normal siblings of children with cancer . | NA | {
"id": "C0022665",
"name": "renal tumours",
"pos": [
70,
83
]
} | {
"id": "C0027708",
"name": "wilms",
"pos": [
89,
94
]
} |
lymphoblastoid cells syngeneic with the tumors were more effective than allogeneic cells , suggesting that an mhc-restricted immune response was induced , or , alternatively , that immune elimination of allogeneic cells prevented them from initiating strong immunity to mdv-associated tumor antigens . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
15,
20
]
} | {
"id": "C3485979",
"name": "allogeneic cells",
"pos": [
203,
219
]
} |
early mortality among f1 chickens immunized with lymphoblastoid cells that were syngeneic with the challenge tumor cells was significantly lower than for non-immunized control chickens or for birds immunized with lymphoblastoid cells that were allogeneic with the challenge tumor cells . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
64,
69
]
} | {
"id": "C3485979",
"name": "allogeneic",
"pos": [
244,
254
]
} |
the effect of cysteamine ( 2-aminoethanethiol hydrochloride ) on hepatocarcinogenesis induced by n-nitrosomorpholine ( nnm ) was investigated in male sprague-dawley rats . | NA | {
"id": "C0010648",
"name": "cysteamine",
"pos": [
14,
24
]
} | {
"id": "C0887458",
"name": "2-aminoethanethiol hydrochloride",
"pos": [
27,
59
]
} |
terazosin is a new , selective , alpha 1-adrenoceptor antagonist which is structurally similar to prazosin and of similar therapeutic efficacy in the treatment of mild-to-moderate essential hypertension . | NA | {
"id": "C0076107",
"name": "terazosin",
"pos": [
0,
9
]
} | {
"id": "C0032912",
"name": "prazosin",
"pos": [
98,
106
]
} |
plasma concentrations of free norepinephrine ( ne ) and free dopamine ( da ) increased from 2.73 +/- 0.28 to 5.41 +/- 1.11 nmol.l-1 and from 0.45 +/- 0.13 to 0.62 +/- 0.18 nmol.l-1 whereas free epinephrine ( e ) and insulin were unchanged ; | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
30,
44
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
194,
205
]
} |
the two continuous-time models are able to mimic trickle infection experiments because both of them represent parasite mortality as an increasing function of the infection rate and the duration of infection . | NA | {
"id": "C0030499",
"name": "parasite",
"pos": [
110,
118
]
} | {
"id": "C0009450",
"name": "infection",
"pos": [
197,
206
]
} |
in vitro studies showed that an ascorbic acid concentration of 15 mm depressed the trypsin activity in three fish species by 50 % , whereas dehydroascorbic acid and ascorbic sulfate did not inhibit trypsin or chymotrypsin activities . | NA | {
"id": "C0003968",
"name": "ascorbic acid",
"pos": [
32,
45
]
} | {
"id": "C0011177",
"name": "dehydroascorbic acid",
"pos": [
140,
160
]
} |
however , this inhibitory action is unlikely in vivo because ascorbic acid is rapidly oxidized in the digestive tract content to the dehydroascorbic acid . | NA | {
"id": "C0003968",
"name": "ascorbic acid",
"pos": [
61,
74
]
} | {
"id": "C0011177",
"name": "dehydroascorbic acid",
"pos": [
133,
153
]
} |
we analyzed the fatty wax esters and sterol esters found in the expressed lipid secretions of six patients from each of six clinical groups of chronic blepharitis , plus eight normal controls . | NA | {
"id": "C0043076",
"name": "wax",
"pos": [
22,
25
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
74,
79
]
} |
radiolabeled hemoglobin may be a useful tool in the study of the body distribution of hemoglobin solutions developed as plasma expanders with oxygen-transporting capacity . | NA | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
13,
23
]
} | {
"id": "C0019016",
"name": "a",
"pos": [
165,
166
]
} |
after in vivo experiments with 45 calculi twelve pigs , seven of them with surgically implanted human gallstones , were treated . | NA | {
"id": "C0006736",
"name": "calculi",
"pos": [
34,
41
]
} | {
"id": "C0008350",
"name": "gallstones",
"pos": [
102,
112
]
} |
in a randomized , prospective double blind trial evaluating antibiotic prophylaxis for internal fixation of proximal femur fractures , the prognostic value of preoperative risk parameters , namely triceps skinfold , upper arm circumference , dynamometry , serum albumin , transferrin , prealbumin , lymphocyte count and ... | NA | {
"id": "C0036773",
"name": "serum albumin",
"pos": [
256,
269
]
} | {
"id": "C0032923",
"name": "prealbumin",
"pos": [
286,
296
]
} |
these findings indicated that , throughout the intestine , the luminal surface contains glycoconjugates with either n- or o-linked glycoprotein , or both , with terminal non-reducing beta-galactosyl and sialyl residues . | NA | {
"id": "C0017906",
"name": "glycoconjugates",
"pos": [
88,
103
]
} | {
"id": "C0017968",
"name": "glycoprotein",
"pos": [
131,
143
]
} |
histopathological material fixed in buffered phenol-formaldehyde ( ph 7.0 ) and rapidly advanced to paraffin in an enclosed tissue-processor showed improved nuclear and cytoplasmic detail , reduced shrinkage and distortion , and an absence of formalin pigment . | NA | {
"id": "C0016564",
"name": "formaldehyde",
"pos": [
52,
64
]
} | {
"id": "C0949307",
"name": "formalin",
"pos": [
243,
251
]
} |
the development of second malignant tumors ( smts ) , in patients who have had their first tumor treated successfully , represents a serious limitation of current therapeutic strategies for head and neck cancers . | NA | {
"id": "C0085183",
"name": "second malignant tumors",
"pos": [
19,
42
]
} | {
"id": "C0027651",
"name": "tumor",
"pos": [
91,
96
]
} |
when compared to normal human fibroblasts the glioma cells were found to be more sensitive to hyperthermia than the normal fibroblasts indicating hyperthermia may be a promising method or adjunct to radiotherapy in the treatment of resistant glioma cells or tumors . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
30,
41
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
249,
254
]
} |
early transplants of a spontaneous mouse fibrosarcoma ( fsa ii ) were used to investigate whether radiation or surgical treatment of a tumor in the leg altered the growth or cell kinetics of a second tumor in the axilla . | NA | {
"id": "C0027651",
"name": "tumor",
"pos": [
135,
140
]
} | {
"id": "C0085183",
"name": "second tumor",
"pos": [
193,
205
]
} |
sixty-four percent of the dogs had tachypnea , 60 % had dyspnea , 56 % vocalized , 52 % were pruritic , 48 % held their necks rigidly , 36 % vomited , 36 % had muscle spasms , 36 % were aggressive , 28 % had trismus , and 24 % had dysphagia . | NA | {
"id": "C0037763",
"name": "muscle spasms",
"pos": [
160,
173
]
} | {
"id": "C0041105",
"name": "trismus",
"pos": [
208,
215
]
} |
the fact that 8-bromo-cyclic amp decreased both androgen and estrogen receptor concentrations suggested that the effect of calcitonin on sex steroid receptors is not mediated by its effect on cyclic amp in these cells . | NA | {
"id": "C0000661",
"name": "8-bromo-cyclic amp",
"pos": [
14,
32
]
} | {
"id": "C0001455",
"name": "cyclic amp",
"pos": [
192,
202
]
} |
the fact that 8-bromo-cyclic amp decreased both androgen and estrogen receptor concentrations suggested that the effect of calcitonin on sex steroid receptors is not mediated by its effect on cyclic amp in these cells . | NA | {
"id": "C0034804",
"name": "estrogen receptor",
"pos": [
61,
78
]
} | {
"id": "C0034840",
"name": "steroid receptors",
"pos": [
141,
158
]
} |
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