text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
the combination of platelet-derived growth factor ( pdgf ) and insulin-like growth factor one ( igf-1 ) has previously been shown to enhance repair of soft tissue wounds . | NA | {
"id": "C0037657",
"name": "insulin-like growth",
"pos": [
63,
82
]
} | {
"id": "C0021665",
"name": "igf-1",
"pos": [
96,
101
]
} |
phospholipids such as egg phosphatidylcholine , phosphatidylserine , synthetic dipalmitoyl-dl-alpha-phosphatidylcholine or phosphatidylinositol , have been used in conjunction with cholesterol and positively or negatively charged amphiphiles such as stearylamine or phosphatidic acid . | NA | {
"id": "C1959616",
"name": "phosphatidylcholine",
"pos": [
26,
45
]
} | {
"id": "C0000039",
"name": "dipalmitoyl",
"pos": [
79,
90
]
} |
the afferent and efferent connections of te1 were identified by using the retrograde and anterograde transport of wheat germ agglutinin conjugated with horseradish peroxidase ( wga-hrp ) . | NA | {
"id": "C0019941",
"name": "horseradish peroxidase",
"pos": [
152,
174
]
} | {
"id": "C0078473",
"name": "wga-hrp",
"pos": [
177,
184
]
} |
the present study provides qualitative and quantitative investigations of the norepinephrine ( ne ) neurons in the locus coeruleus ( lc ) in two neurodegenerative disorders , the senile dementia of the alzheimer type ( sdat ) and parkinson 's disease ( pd ) . | NA | {
"id": "C0524851",
"name": "neurodegenerative",
"pos": [
145,
162
]
} | {
"id": "C0030567",
"name": "parkinson 's",
"pos": [
230,
242
]
} |
the steps involved are ( 1 ) attachment of the virus to a receptor protein on the surface of the target cell , ( 2 ) entry of the virus into the cell , ( 3 ) replication of the viral genome through a dna intermediary , ( 4 ) entry of proviral dna into the nucleus of the host cell , ( 5 ) integration of proviral dna int... | NA | {
"id": "C0000702",
"name": "a dna",
"pos": [
198,
203
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
377,
380
]
} |
the efficacy of a new hydrocolloid dressing occlusion , alone or with 0.1 % triamcinolone cream , was compared with triamcinolone acetonide alone or under plastic film occlusion in the treatment of localized plaque-type psoriasis . | NA | {
"id": "C0040864",
"name": "triamcinolone",
"pos": [
76,
89
]
} | {
"id": "C0040866",
"name": "triamcinolone acetonide",
"pos": [
116,
139
]
} |
sixteen reacted to tixocortol pivalate and also to other corticosteroids , particularly to hydrocortisone , which could explain exacerbations of eczema in these cases . | NA | {
"id": "C0076748",
"name": "tixocortol pivalate",
"pos": [
19,
38
]
} | {
"id": "C0020268",
"name": "hydrocortisone",
"pos": [
91,
105
]
} |
a glycoprotein that reacted to the antisoluble glycoprotein of bovine milk fat globule membrane was purified from the proteose-peptone of whey and designated lactophorin . | NA | {
"id": "C0017968",
"name": "glycoprotein",
"pos": [
2,
14
]
} | {
"id": "C0025248",
"name": "glycoprotein",
"pos": [
47,
59
]
} |
the resolving power of conventional preparative protein separation techniques such as ion-exchange chromatography , chromatofocusing and lectin affinity chromatography is too poor for a complete separation of isoproteins . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
48,
55
]
} | {
"id": "C0023206",
"name": "lectin",
"pos": [
137,
143
]
} |
pigs of varying age , newborn ( oh ) , 36-45 h old and 22-28 days old , were gavage fed polyethylene glycol 1000 together with the macromolecular markers bovine serum albumin , ovalbumin or fitc-labelled dextran 70,000 . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
167,
174
]
} | {
"id": "C0029923",
"name": "ovalbumin",
"pos": [
177,
186
]
} |
in vitro studies showed that when quiescent ( ki-67-negative ) nih 3t3 fibroblasts or bovine peripheral blood lymphocytes were induced to proliferate , the appearance of ki-67-positive cells paralleled the induction of cell proliferation caused by addition of fetal calf serum or pha , respectively , to the cultures , a... | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
71,
82
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
359,
364
]
} |
with the use of radioimmunoassays , western immunoblots of native and denatured myosins , and epifluorescent indirect immunocytochemistry , we show that ald 180 is specific for an epitope in human prenatal skeletal muscle myosin heavy chain ( mhc ) , which is expressed in diminishing abundance in fetal fibers from at l... | NA | {
"id": "C0027096",
"name": "myosins",
"pos": [
80,
87
]
} | {
"id": "C0027100",
"name": "myosin",
"pos": [
222,
228
]
} |
we describe an alternative polyethylene glycol ( peg ) embedding procedure which utilizes peg 200 for dehydration and peg 600 for infiltration and embedding of perfusion-fixed rat liver . | NA | {
"id": "C0032483",
"name": "polyethylene glycol",
"pos": [
27,
46
]
} | {
"id": "C0982313",
"name": "peg 200",
"pos": [
90,
97
]
} |
both plasma levels and urinary excretion of norepinephrine and epinephrine were elevated in the 5/6-nephrectomized rats compared with controls . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
44,
58
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
63,
74
]
} |
blood pressure control and haemodynamic adaptation with the dihydropyridine calcium antagonist isradipine : a controlled study in middle-aged hypertensive men . | NA | {
"id": "C2945601",
"name": "dihydropyridine",
"pos": [
60,
75
]
} | {
"id": "C0071304",
"name": "isradipine",
"pos": [
95,
105
]
} |
twenty-three middle-aged men ( 59 +/- 2 years ) with sustained , essential hypertension ( who stage ii ) and with diastolic blood pressure exceeding 100 mmhg during a run-in placebo month were included in a trial designed to assess the clinical and haemodynamic effects of isradipine , a novel dihydropyridine calcium an... | NA | {
"id": "C0071304",
"name": "isradipine",
"pos": [
273,
283
]
} | {
"id": "C2945601",
"name": "dihydropyridine calcium",
"pos": [
294,
317
]
} |
when individually cross-linked with goat anti-mouse igg antibody immobilized on plastic surface , only anti-cd3 and anti-cd28 mab were able to induce t cell proliferation . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
56,
64
]
} | {
"id": "C0003250",
"name": "mab",
"pos": [
126,
129
]
} |
or with certain bacterial cell wall components : murein ( peptidoglycan ) , and its synthetic derivatives , muramyltripeptide phosphatidylethanolamine and desmethyl-muramyldipeptide , but not with lps , core lipid a or lipoprotein ; | NA | {
"id": "C0023810",
"name": "lps",
"pos": [
197,
200
]
} | {
"id": "C0023767",
"name": "lipid a",
"pos": [
208,
215
]
} |
antibodies directed to sites i and ii neutralized the antiviral and antiproliferative activities of rhuifn-beta ser , though the antiviral neutralization potency of the mab to site ii was approximately 10-fold less than mab to site i . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
0,
10
]
} | {
"id": "C0003250",
"name": "mab",
"pos": [
220,
223
]
} |
lowering the intracellular gsh level of pbmc to less than 10 % of the initial content prior to mitogenic stimulation did not impair the ability of these cells to produce il-2 and express il-2r , indicating that gsh may not be involved in the generation and response to early activation signals . | NA | {
"id": "C1321301",
"name": "pbmc",
"pos": [
40,
44
]
} | {
"id": "C0007634",
"name": "the",
"pos": [
238,
241
]
} |
this t cell epitope was located between residues 116 and 121 , adjacent to an epitope between residues 110 and 115 which we have previously shown to bind the l5 mab . | NA | {
"id": "C0282580",
"name": "t cell epitope",
"pos": [
5,
19
]
} | {
"id": "C0003316",
"name": "epitope",
"pos": [
78,
85
]
} |
cloned ctl specific for either an internal ( nucleoprotein ) or surface ( glycoprotein ) protein of lymphocytic choriomeningitis virus , when administered intracerebrally 5 days after the initiation of infection induced fatal immunopathology , indicating that both internal and surface viral ag play a role in immune med... | NA | {
"id": "C0028612",
"name": "nucleoprotein",
"pos": [
45,
58
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
89,
96
]
} |
the in vitro generation of allospecific ctl by human pbmc was enhanced 4- to 16-fold by sequential plastic and nylon wool adherence , which depleted the pbmc of macrophages and b cells . | NA | {
"id": "C0032167",
"name": "plastic",
"pos": [
99,
106
]
} | {
"id": "C0028736",
"name": "nylon",
"pos": [
111,
116
]
} |
the suppressor function could be abrogated by preincubation of irradiated pbmc with influenza a virus before the coculture with depleted cells . | NA | {
"id": "C1321301",
"name": "pbmc",
"pos": [
74,
78
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
137,
142
]
} |
this response to il-1 plus il-2 could be induced by il-1 alpha or il-1 beta and by membrane-bound il-1 on macrophages . | NA | {
"id": "C0600251",
"name": "il-1 alpha",
"pos": [
52,
62
]
} | {
"id": "C0021755",
"name": "il-1",
"pos": [
98,
102
]
} |
we have shown that this antibody ( 1f5 ) of igg1 isotype blocks the action of a 20-kda membrane inhibitor capable of interfering with the terminal step in the homologous c cascade . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
24,
32
]
} | {
"id": "C0021017",
"name": "isotype",
"pos": [
49,
56
]
} |
the objective of this study was to investigate the cellular origin of hrif produced by pbmc . | NA | {
"id": "C0007634",
"name": "cellular",
"pos": [
51,
59
]
} | {
"id": "C1321301",
"name": "pbmc",
"pos": [
87,
91
]
} |
inasmuch as added ffa primarily binds to membrane lipid , is not appreciably esterified , and the inhibition is reversed by treatment with fatty acid free bsa , it is likely that the oleic acid effects are due to a physical perturbation of membrane lipid . | NA | {
"id": "C0015688",
"name": "ffa",
"pos": [
18,
21
]
} | {
"id": "C0015684",
"name": "fatty acid",
"pos": [
139,
149
]
} |
mhc restriction of the antibody repertoire to secretory antigens , and a major allergen , of the nematode parasite ascaris . | NA | {
"id": "C0003320",
"name": "antigens",
"pos": [
56,
64
]
} | {
"id": "C0002092",
"name": "allergen",
"pos": [
79,
87
]
} |
in cold target competition experiments with lak cell effectors and radiolabeled k562 target cells , tnf-primed ec were no more competitive than unstimulated ec , and in assays with unstimulated pbmc effectors , the addition of unlabeled tnf-activated ec actually increased the cytolysis of the radiolabeled tumor cells . | NA | {
"id": "C1321301",
"name": "pbmc",
"pos": [
194,
198
]
} | {
"id": "C0007634",
"name": "the",
"pos": [
290,
293
]
} |
in contrast to these effects , all-trans retinoic acid treatment of keratinocytes in kbm , in which the cells were normally quiescent , stimulated growth . | NA | {
"id": "C0022567",
"name": "kbm",
"pos": [
85,
88
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
104,
109
]
} |
the action of vitamin a ( retinol ) and the synthetic retinoids , isotretinoin , etretinate , acitretin , and arotinoid-free acid have been studied on the lymphocyte proliferation induced by phytohemagglutinin ( pha ) , by the mixed lymphocyte reaction ( mlr ) , and the mixed epidermal cell-lymphocyte reaction ( meclr ... | NA | {
"id": "C0042839",
"name": "vitamin a",
"pos": [
14,
23
]
} | {
"id": "C0035339",
"name": "retinoids",
"pos": [
54,
63
]
} |
the action of vitamin a ( retinol ) and the synthetic retinoids , isotretinoin , etretinate , acitretin , and arotinoid-free acid have been studied on the lymphocyte proliferation induced by phytohemagglutinin ( pha ) , by the mixed lymphocyte reaction ( mlr ) , and the mixed epidermal cell-lymphocyte reaction ( meclr ... | NA | {
"id": "C0035339",
"name": "retinoids",
"pos": [
54,
63
]
} | {
"id": "C0022265",
"name": "isotretinoin",
"pos": [
66,
78
]
} |
sod activity in fibroblasts originating from seven xeroderma pigmentosum ( xp ) patients was significantly lower than that in normal cells ( p less than 0.005 ) . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
16,
27
]
} | {
"id": "C0007634",
"name": "normal cells",
"pos": [
126,
138
]
} |
these studies confirm that il-1 alpha is the predominant form of il-1 in the skin and provide further support for the hypothesis that il-1 participates in the pathogenesis of psoriasis . | NA | {
"id": "C0600251",
"name": "il-1 alpha",
"pos": [
27,
37
]
} | {
"id": "C0021755",
"name": "il-1",
"pos": [
134,
138
]
} |
in order to determine the effector subpopulation against meth-a cells , the spleen cells obtained from the tumor-bearing mice treated with ok-432 and ril-2 on the 12th day after tumor transplantation , were treated with either anti-thy-1 , 2 antibody plus complement , anti-asialo gm1 serum plus complement , or by adher... | NA | {
"id": "C0032167",
"name": "plastic",
"pos": [
330,
337
]
} | {
"id": "C0028736",
"name": "nylon",
"pos": [
347,
352
]
} |
always have a sample of the main drinking water source ( usually home water ) analyzed for the fluoride content before prescribing a fluoride supplement , if you do not have other specific knowledge of water fluoride content . | NA | {
"id": "C0599638",
"name": "drinking water",
"pos": [
33,
47
]
} | {
"id": "C0043047",
"name": "water",
"pos": [
202,
207
]
} |
previously we have described the isolation of seven monoclonal antibodies ( mabs ) and two polyvalent rabbit sera directed against the product of herpes simplex virus type 1 ( hsv-1 ) gene ul42 , a 65k dna-binding protein ( 65kdbp ) which is essential for hsv dna replication and virus growth . | NA | {
"id": "C0033684",
"name": "product",
"pos": [
135,
142
]
} | {
"id": "C0012940",
"name": "dna-binding protein",
"pos": [
202,
221
]
} |
the phosphopeptide fingerprint could be significantly influenced in vivo by the specific stimulation of cellular protein kinase c by the phorbol ester 12-o-tetradecanoylphorbol 13-acetate or by its inhibition with the isoquinoline sulphonamide h7.h7 specifically inhibited the replication of influenza a viruses by dereg... | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
137,
150
]
} | {
"id": "C0039654",
"name": "12-o-tetradecanoylphorbol 13-acetate",
"pos": [
151,
187
]
} |
moreover , it also provides an explanation for the beta 1-selectivity of p-phenyl substituted phenoxypropanolamines like betaxolol . | NA | {
"id": "C1563753",
"name": "phenoxypropanolamines",
"pos": [
94,
115
]
} | {
"id": "C0005320",
"name": "betaxolol",
"pos": [
121,
130
]
} |
one hundred forty-three patients with gliomas of astrocytic origin ( 61 with glioblastomas multiforme ( gm ) and 82 with astrocytomas ) received an intravenous infusion of bromodeoxyuridine ( budr ) , 150-200 mg/m2 at the time of surgery , to label tumor cells undergoing dna synthesis . | NA | {
"id": "C0017636",
"name": "glioblastomas multiforme",
"pos": [
77,
101
]
} | {
"id": "C0004114",
"name": "astrocytomas",
"pos": [
121,
133
]
} |
values of a-axis length for the hydroxyapatites ranged from 9.406 a to 9.416 a , which were smaller than the corresponding value for stoichimetric hydroxyapatite , a = 9.418 a . | NA | {
"id": "C0020326",
"name": "hydroxyapatites",
"pos": [
32,
47
]
} | {
"id": "C0115137",
"name": "hydroxyapatite",
"pos": [
147,
161
]
} |
these results suggest that the synthetic hydroxyapatites contained some carbonate ions , probably at the a-site of the apatite structure , and that the structure was depleted of carbonate ions at about 500 degrees c . | NA | {
"id": "C0020326",
"name": "hydroxyapatites",
"pos": [
41,
56
]
} | {
"id": "C0003522",
"name": "apatite",
"pos": [
119,
126
]
} |
so far , interstitial radiotherapy using low activity permanent or temporary implants has been carried out in 179 patients with differentiated gliomas ( 132 cases ) and other tumors-anaplastic gliomas and glioblastomas ( 16 cases ) , ependymomas and papillomas ( 4 cases ) and a variety of other mostly extracerebral tum... | NA | {
"id": "C0017638",
"name": "gliomas",
"pos": [
143,
150
]
} | {
"id": "C0014474",
"name": "ependymomas",
"pos": [
234,
245
]
} |
groups of rats were fed a fiber-free diet deficient in vitamin b-12 or the fiber-free diet diluted with 5 % of a poorly fermentable dietary fiber ( cellulose , lignin or alginic acid ) or a highly fermentable fiber ( pectin , guar gum or xylan ) . | NA | {
"id": "C0007648",
"name": "cellulose",
"pos": [
148,
157
]
} | {
"id": "C0023705",
"name": "lignin",
"pos": [
160,
166
]
} |
the multiphasic response of plasma radioactivity during a physiological steady state was explained on the basis of rapid hepatic uptake of selenium and its subsequent reappearance in the circulation in protein-bound form followed by further metabolism and excretion of the element . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
241,
251
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
256,
265
]
} |
maternal education , caloric and vitamin a intakes , weight , height , hemoglobin , and birth weight were significantly lower in group ii . | NA | {
"id": "C0005910",
"name": "weight",
"pos": [
53,
59
]
} | {
"id": "C0005612",
"name": "birth weight",
"pos": [
88,
100
]
} |
to optimize ca/p delivery , we tested the effects on in vitro solubility of mineral salt : calcium glycerophosphate ( cagp ) versus calcium gluconate and k2hpo4 ( cg + p ) ; | NA | {
"id": "C0006675",
"name": "ca",
"pos": [
12,
14
]
} | {
"id": "C0006700",
"name": "calcium glycerophosphate",
"pos": [
91,
115
]
} |
to optimize ca/p delivery , we tested the effects on in vitro solubility of mineral salt : calcium glycerophosphate ( cagp ) versus calcium gluconate and k2hpo4 ( cg + p ) ; | NA | {
"id": "C0006675",
"name": "ca",
"pos": [
12,
14
]
} | {
"id": "C0006699",
"name": "calcium",
"pos": [
132,
139
]
} |
thus , ( a ) early changes in animals ' dietary content of cholesterol may have prolonged effects on intestinal transport function , and ( b ) this early feeding experience with cholesterol may alter the adaptive pattern of the intestine when animals are exposed to a dietary cholesterol challenge at a later age . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
59,
70
]
} | {
"id": "C0008395",
"name": "dietary cholesterol",
"pos": [
268,
287
]
} |
y4 lipid a was obtained by the hydrolysis of y4 lps in 1 % acetic acid . | NA | {
"id": "C0023767",
"name": "lipid a",
"pos": [
3,
10
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
48,
51
]
} |
all the lps preparations and y4 lipid a were mitogenic for c3h/hen mouse spleen cells , but not for c3h/hej mouse spleen cells . | NA | {
"id": "C0023810",
"name": "lps",
"pos": [
8,
11
]
} | {
"id": "C0023767",
"name": "lipid a",
"pos": [
32,
39
]
} |
immunoglobulin preparations partially purified by ammonium sulfate precipitation at 33 % saturation from rabbit antisera against y4 whole cells inhibited the mitogenic response of c3h/hen mouse spleen cells to lpss from all the strains of a. actinomycetemcomitans and y4 lipid a . | NA | {
"id": "C0023810",
"name": "lpss",
"pos": [
210,
214
]
} | {
"id": "C0023767",
"name": "lipid a",
"pos": [
271,
278
]
} |
anti-y4 lps immunoglobulin preparation inhibited the mitogenic activity of y4 lps and y4 lipid a . | NA | {
"id": "C0023810",
"name": "lps",
"pos": [
8,
11
]
} | {
"id": "C0023767",
"name": "lipid a",
"pos": [
89,
96
]
} |
furthermore , anti-y4 whole cell fab fragments inhibited the mitogenic activity of both y4 lps and y4 lipid a . | NA | {
"id": "C0023810",
"name": "lps",
"pos": [
91,
94
]
} | {
"id": "C0023767",
"name": "lipid a",
"pos": [
102,
109
]
} |
experimental defects associated with the right canine and its surrounding bone were covered by collagen membranes prepared by air drying gels of rat type i fibrillar collagen . | NA | {
"id": "C0009325",
"name": "collagen",
"pos": [
95,
103
]
} | {
"id": "C0969669",
"name": "fibrillar",
"pos": [
156,
165
]
} |
this new preparation could be used to study the contribution of the microcirculation to gingivitis , the role of gingivitis in the development of periodontal disease , or the effects of drugs and hormones on the microcirculation of the gingiva . | NA | {
"id": "C0017574",
"name": "gingivitis",
"pos": [
88,
98
]
} | {
"id": "C0017563",
"name": "periodontal disease",
"pos": [
146,
165
]
} |
eight patients with moderate periodontitis volunteered to participate in a study to assess the effect of subgingival 2 % chlorhexidine irrigation , with and without scaling and root planing , on clinical parameters and the level of bacteroides gingivalis in periodontal pockets . | NA | {
"id": "C0031099",
"name": "periodontitis",
"pos": [
29,
42
]
} | {
"id": "C0031094",
"name": "periodontal pockets",
"pos": [
258,
277
]
} |
the sharpness and wear of stainless steel ( ss ) and high carbon steel ( hcs ) dental curettes were compared before and after standardized root planing procedures . | NA | {
"id": "C0038126",
"name": "stainless steel",
"pos": [
26,
41
]
} | {
"id": "C0038239",
"name": "steel",
"pos": [
65,
70
]
} |
microscopic observations showed that edge deformation increased from the control ( factory sharpened ) group , to the `` '' 15 stroke '' '' group , and from the `` '' 15 '' '' to the `` '' 45 stroke '' '' group , in both ss and hcs curettes . | NA | {
"id": "C0038126",
"name": "b",
"pos": [
13,
14
]
} | {
"id": "C0038239",
"name": "",
"pos": [
242,
245
]
} |
after 45 strokes , only 5 % of the ss curettes were sharp , compared to 20 % of the hcs curettes . | NA | {
"id": "C0038126",
"name": "ss",
"pos": [
35,
37
]
} | {
"id": "C0038239",
"name": "hcs",
"pos": [
84,
87
]
} |
while 65 % of the ss curettes showed severe edge deformation by the end of the study , only 20 % of the hcs curettes were severely deformed ( p less than 0.01 ) . | NA | {
"id": "C0038126",
"name": "ss",
"pos": [
18,
20
]
} | {
"id": "C0038239",
"name": "hcs",
"pos": [
104,
107
]
} |
rat serum obtained at 24 h after subcutaneous injection of carrageenin significantly suppressed chemotaxis of rat polymorphonuclear leukocytes ( pmns ) in vitro . alpha 2 acute-phase macroglobulin ( alpha 2apm ) , alpha 1 proteinase inhibitor ( alpha 1 pi ) and cysteine-proteinase inhibitors ( cpis ) are present at hig... | NA | {
"id": "C0002191",
"name": "alpha 1 proteinase",
"pos": [
214,
232
]
} | {
"id": "C0001347",
"name": "acute-phase reactants",
"pos": [
367,
388
]
} |
however , in-vivo administration of nefopam to rats does not diminish the gsh content of liver cytosol nor increase oxidized glutathione levels nor alter the activities of gsh transferase and gsh peroxidase . | NA | {
"id": "C0061516",
"name": "oxidized",
"pos": [
116,
124
]
} | {
"id": "C0017817",
"name": "gsh",
"pos": [
192,
195
]
} |
the bioavailability of alpha-tocopherol acetate and alpha-tocopherol ( vitamin e ) was assessed in male rabbits given 50 mg kg-1 doses according to a randomized design . | NA | {
"id": "C1999896",
"name": "alpha-tocopherol acetate",
"pos": [
23,
47
]
} | {
"id": "C0969677",
"name": "alpha-tocopherol",
"pos": [
52,
68
]
} |
the bioavailability of alpha-tocopherol acetate and alpha-tocopherol ( vitamin e ) was assessed in male rabbits given 50 mg kg-1 doses according to a randomized design . | NA | {
"id": "C1999896",
"name": "alpha-tocopherol acetate",
"pos": [
23,
47
]
} | {
"id": "C0042874",
"name": "vitamin e",
"pos": [
71,
80
]
} |
after intramuscular injection of alpha-tocopherol acetate in colloidal aqueous solution , a mean absolute bioavailability of 65 % was calculated for the acetate and 35 % for the physiologically active compound , alpha-tocopherol . | NA | {
"id": "C1999896",
"name": "alpha-tocopherol acetate",
"pos": [
33,
57
]
} | {
"id": "C0969677",
"name": "alpha-tocopherol",
"pos": [
212,
228
]
} |
comparison of the kinetic profiles after intravenous and intramuscular administration of the acetate and intravenous injection of alpha-tocopherol , revealed absorption of alpha-tocopherol acetate from the site of injection and hydrolysis of the acetate to be potential limiting steps in the bioavailability of alpha-toc... | NA | {
"id": "C1999896",
"name": "alpha-tocopherol acetate",
"pos": [
172,
196
]
} | {
"id": "C0969677",
"name": "alpha-tocopherol",
"pos": [
311,
327
]
} |
because biodegradation rate of embolized particles will influence rate of incorporated drug release and duration of exposure , this parameter was studied for microspheres ( 10-30 microns mean diam . ) prepared from the proteins albumin and casein , that we have previously used as carriers for doxorubicin . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
219,
227
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
228,
235
]
} |
the selective mu-opioid agonist [ d-ala2 , mephe4 , gly-ol5 ] enkephalin ( dago ) ( 10 microm ) reduced the short circuit ( isc ) and the l-valine induced increase of the transepithelial potential difference and isc ( delta vms and delta isc ) measured in-vitro in rabbit ileum , with a mechanism antagonized by naloxone... | NA | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
62,
72
]
} | {
"id": "C0525773",
"name": "dago",
"pos": [
75,
79
]
} |
the inter- and intrapersonal variability in the absorption and disposition of erythromycin estolate in humans was assessed by comparing total erythromycin serum concentrations in five subjects who each received a single erythromycin estolate tablet on three separate occasions under identical experimental conditions . | NA | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
78,
90
]
} | {
"id": "C0014809",
"name": "erythromycin",
"pos": [
220,
232
]
} |
bulk quantities and pharmaceutical preparations of the antineoplastic drugs carmustine ( bcnu ) , lomustine ( ccnu ) , chlorozotocin , n- [ 2-chloroethyl ] -n'- [ 2,6-dioxo-3-piperidinyl ] -n-nitrosourea ( pcnu ) , methyl ccnu , mechlorethamine , melphalan , chlorambucil , cyclophosphamide , ifosfamide , uracil mustard... | NA | {
"id": "C0023972",
"name": "lomustine",
"pos": [
98,
107
]
} | {
"id": "C0036637",
"name": "methyl",
"pos": [
215,
221
]
} |
bulk quantities and pharmaceutical preparations of the antineoplastic drugs carmustine ( bcnu ) , lomustine ( ccnu ) , chlorozotocin , n- [ 2-chloroethyl ] -n'- [ 2,6-dioxo-3-piperidinyl ] -n-nitrosourea ( pcnu ) , methyl ccnu , mechlorethamine , melphalan , chlorambucil , cyclophosphamide , ifosfamide , uracil mustard... | NA | {
"id": "C0010583",
"name": "cyclophosphamide",
"pos": [
274,
290
]
} | {
"id": "C0020823",
"name": "ifosfamide",
"pos": [
293,
303
]
} |
two techniques , high-performance liquid chromatography ( hplc ) and quantitative high-performance thin-layer chromatography coupled with densitometry ( hptlc ) , were developed for the determination of prednisolone ( pl ) , methylprednisolone ( mp ) , and methylprednisolone sodium succinate ( mpss ) in human plasma , ... | NA | {
"id": "C0025815",
"name": "methylprednisolone",
"pos": [
225,
243
]
} | {
"id": "C0700546",
"name": "methylprednisolone sodium succinate",
"pos": [
257,
292
]
} |
the limit of detection of both assays for pl and mp was 10 ng/ml in plasma and saliva and 25 ng/ml in urine , and of mpss was 50 ng/ml in plasma . | NA | {
"id": "C0025815",
"name": "mp",
"pos": [
49,
51
]
} | {
"id": "C0700546",
"name": "mpss",
"pos": [
117,
121
]
} |
the application of these methods for the pharmacokinetic study of both mp and pl in vivo and the in vitro hydrolysis of mpss is discussed . | NA | {
"id": "C0025815",
"name": "mp",
"pos": [
71,
73
]
} | {
"id": "C0700546",
"name": "mpss",
"pos": [
120,
124
]
} |
the influence of i.v . vs. i.c.v . administration of [ ( d-ala2 , metphe4 , gly-ol5 ] enkephalin ( damgo ) and morphine ) , kappa u 50488 and ethylketocyclazocine and delta ( [ d-pen2 , d-pen5 ] enkephalin ( dpdpe ) ] opioid agonists on gastric relaxation induced by a standard meal was evaluated in conscious dogs with ... | NA | {
"id": "C0525773",
"name": "damgo",
"pos": [
99,
104
]
} | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
195,
205
]
} |
the influence of i.v . vs. i.c.v . administration of [ ( d-ala2 , metphe4 , gly-ol5 ] enkephalin ( damgo ) and morphine ) , kappa u 50488 and ethylketocyclazocine and delta ( [ d-pen2 , d-pen5 ] enkephalin ( dpdpe ) ] opioid agonists on gastric relaxation induced by a standard meal was evaluated in conscious dogs with ... | NA | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
86,
96
]
} | {
"id": "C0525856",
"name": "dpdpe",
"pos": [
208,
213
]
} |
4-ip1 was the predominant ip1 isomer formed during stimulation with norepinephrine suggesting that the polyphosphoinositides rather than phosphatidylinositol are the principal targets of norepinephrine-stimulated phospholipase c activity in the heart . | NA | {
"id": "C0071655",
"name": "polyphosphoinositides",
"pos": [
103,
124
]
} | {
"id": "C0031621",
"name": "phosphatidylinositol",
"pos": [
137,
157
]
} |
the influence of the acute ( single dose ) or subchronic ( one dose daily for 4 days ) administration of cocaine to sprague-dawley rats on striatal enkephalin ( met5-enkephalin ) and striatonigral tachykinin ( substance p ) and dynorphin [ dynorphin a ( 1-8 ) , dyn ] levels was investigated . | NA | {
"id": "C0039241",
"name": "tachykinin",
"pos": [
197,
207
]
} | {
"id": "C0038585",
"name": "substance p",
"pos": [
210,
221
]
} |
a similar order of affinity or potency ( saralasin much greater than exp6803 greater than exp6159 greater than exp6155 greater than s8308 ) was observed in various in vitro and in vivo assays : rat smooth muscle cells aii binding , 45ca++ influx in rat aortic rings , contractile response in isolated rabbit aorta and ai... | NA | {
"id": "C0036193",
"name": "saralasin",
"pos": [
41,
50
]
} | {
"id": "C0003009",
"name": "aii",
"pos": [
318,
321
]
} |
the effects on nociception , motor and autonomic function produced by the intrathecal administration of three adenosine analogs : n6- ( l-2-phenylisopropyl ) -adenosine , n6-cyclohexyladenosine and 5'- ( n-ethylcarboxamido ) -adenosine were examined in rats . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
110,
119
]
} | {
"id": "C0050789",
"name": "n-ethylcarboxamido",
"pos": [
204,
222
]
} |
in addition , 5'- ( n-ethylcarboxamido ) -adenosine and n6- ( l-2-phenylisopropyl ) -adenosine both suppressed the chemically evoked writhing response as well as the touch-evoked hyperesthesia normally observed in rats receiving low doses of intrathecal strychnine . | NA | {
"id": "C0050789",
"name": "n-ethylcarboxamido",
"pos": [
20,
38
]
} | {
"id": "C0001443",
"name": "adenosine",
"pos": [
85,
94
]
} |
when inside-out patches were prepared , channel availability was abolished and was reactivated by internal application of guanosine 5'-triphosphate ( gtp ) or its non-hydrolysable analogue , 5'-guanylyl imidodiphosphate ( gppnhp ) , in the presence of mg2+ . | NA | {
"id": "C0018353",
"name": "guanosine",
"pos": [
122,
131
]
} | {
"id": "C0018366",
"name": "guanylyl",
"pos": [
194,
202
]
} |
adenosine caused responses similar to those induced by atp in both ah and s neurones , but was less effective than atp . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
0,
9
]
} | {
"id": "C0001480",
"name": "atp",
"pos": [
115,
118
]
} |
caffeine ( 100 microm ) , theophylline ( 100 microm ) and 3-isobutyl-1-methylxanthine ( 1-10 microm ) did not significantly affect the atp-induced depolarization but did reversibly depress the atp-induced hyperpolarization . | NA | {
"id": "C0039771",
"name": "theophylline",
"pos": [
26,
38
]
} | {
"id": "C0000096",
"name": "3-isobutyl-1-methylxanthine",
"pos": [
58,
85
]
} |
the branched-chain amino acids ( bcaa ) and the aromatic amino acid , phenylalanine , are almost equivalent substrates for an l-like system . | NA | {
"id": "C0301713",
"name": "aromatic amino acid",
"pos": [
48,
67
]
} | {
"id": "C0031453",
"name": "phenylalanine",
"pos": [
70,
83
]
} |
with the exception of alanine , whose transport was partially na+ dependent , all other amino acids examined in the present study were transported in a na+-independent manner . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
22,
29
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
88,
99
]
} |
this did not occur with enalaprilat ( auc 710.1 +/- 51.2 ng.h/ml ( enalapril ) vs 681.9 +/- 44.9 ng.h/ml ( enalapril + hydralazine ) ; mean +/- sem ) . | NA | {
"id": "C0014027",
"name": "enalaprilat",
"pos": [
24,
35
]
} | {
"id": "C0014025",
"name": "enalapril",
"pos": [
107,
116
]
} |
this rigidity was partly related to an increased tone of the arterial smooth muscle in shr compared with the wky . | NA | {
"id": "C0026837",
"name": "rigidity",
"pos": [
5,
13
]
} | {
"id": "C0026826",
"name": "increased tone",
"pos": [
39,
53
]
} |
with respect to the binding of 4 nm [ 3h ] cortisol to the membrane , the affinities of the steroids decreased in the following order : deoxycorticosterone greater than corticosterone greater than progesterone greater than cortisol greater than prednisolone greater than testosterone greater than 20 beta-hydroxyprogeste... | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
197,
209
]
} | {
"id": "C0012311",
"name": "20",
"pos": [
297,
299
]
} |
the covalent thiol-reversible reaction of dtnb occurred on the exofacial carrier , since ( i ) penetration of dtnb into cells was minimal , ( ii ) blockade of potential uptake via the anion transporter did not affect dtnb-induced hexose transport inhibition , and ( iii ) dtnb protected from transport inhibition by the ... | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
184,
189
]
} | {
"id": "C0021966",
"name": "i",
"pos": [
372,
373
]
} |
sds-polyacrylamide gel electrophoresis and immunoblotting were used to investigate inter- and intramolecular disulfide bonds to connexin 43 ( the cardiac gap junctional protein ) in isolated rat heart gap junctions and in whole heart fractions . | NA | {
"id": "C0110613",
"name": "connexin 43",
"pos": [
128,
139
]
} | {
"id": "C0110611",
"name": "gap junctional protein",
"pos": [
154,
176
]
} |
in the control group ( rat hearts ) , arrhythmias including ventricular fibrillation ( vf ) ( incidence , 64.3 to 83.3 % ) , ventricular tachycardia ( vt ) ( 66.7 to 84.6 % ) , premature ventricular contraction ( pvc ) and premature atrial contraction ( pac ) occurred immediately after reperfusion and lasted for 1 to 3... | NA | {
"id": "C0003811",
"name": "arrhythmias",
"pos": [
38,
49
]
} | {
"id": "C0042510",
"name": "ventricular fibrillation",
"pos": [
60,
84
]
} |
to determine whether this effect of pla2 is mediated by membrane accumulation of non-esterified fatty acids ( ffa ) , the effect of selected fatty acids on the binding of 3h-quinuclidinyl benzylate ( 3h-qnb ) to purified canine sarcolemmal membranes before and after pla2 treatment was examined . | NA | {
"id": "C0015688",
"name": "ffa",
"pos": [
110,
113
]
} | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
141,
152
]
} |
the effect of unsaturated fatty acids was dependent on the mole ratio of fatty acid to membrane phospholipid present ( ffa/pl ratio ) . | NA | {
"id": "C0015690",
"name": "unsaturated fatty acids",
"pos": [
14,
37
]
} | {
"id": "C0015684",
"name": "fatty acid",
"pos": [
73,
83
]
} |
the effect of unsaturated fatty acids was dependent on the mole ratio of fatty acid to membrane phospholipid present ( ffa/pl ratio ) . | NA | {
"id": "C0015684",
"name": "fatty acid",
"pos": [
26,
36
]
} | {
"id": "C0015688",
"name": "ffa",
"pos": [
119,
122
]
} |
the fatty acid-induced reduction of bmax was also attenuated if binding was started by simultaneous addition of 3h-qnb and ffa . | NA | {
"id": "C0015684",
"name": "fatty acid",
"pos": [
4,
14
]
} | {
"id": "C0015688",
"name": "ffa",
"pos": [
123,
126
]
} |
we conclude that when reperfusion is elicited at the moment of peak susceptibility to arrhythmias , vf incidence is determined principally by occluded zone size . | NA | {
"id": "C0003811",
"name": "arrhythmias",
"pos": [
86,
97
]
} | {
"id": "C0042510",
"name": "vf",
"pos": [
100,
102
]
} |
however , rate of sah formation in the presence of adenosine dialdehyde was only slightly enhanced from 160 to 200 pmol/g/min and adenosine dialdehyde did not significantly alter the hypoxia induced adenosine release . | NA | {
"id": "C0036001",
"name": "sah",
"pos": [
18,
21
]
} | {
"id": "C0001443",
"name": "adenosine",
"pos": [
199,
208
]
} |
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