text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
iso stimulation of gh and camp : comparison of beta-adrenergic- to grf-stimulated gh release and camp accumulation in monolayer cultures of anterior pituitary cells in vitro . | NA | {
"id": "C0037663",
"name": "gh",
"pos": [
19,
21
]
} | {
"id": "C0032016",
"name": "anterior pituitary",
"pos": [
140,
158
]
} |
growth hormone ( gh ) release and camp content were measured in monolayer cultures of anterior pituitary cells after beta-adrenergic and gh-releasing factor ( grf ) receptor activation . | NA | {
"id": "C0037663",
"name": "growth hormone",
"pos": [
0,
14
]
} | {
"id": "C0032016",
"name": "anterior pituitary",
"pos": [
86,
104
]
} |
together , these studies suggest that a mixed population of beta 1-adrenergic and beta 2-adrenergic receptors may act , at least in part , on somatotrophs in the anterior pituitary to stimulate gh release . | NA | {
"id": "C0032016",
"name": "anterior pituitary",
"pos": [
162,
180
]
} | {
"id": "C0037663",
"name": "gh",
"pos": [
194,
196
]
} |
the landau-kleffner syndrome is an acquired condition in children consisting of aphasia and epileptic discharges in the eeg with or without clinical manifestation of epilepsy . | NA | {
"id": "C0282512",
"name": "landau-kleffner syndrome",
"pos": [
4,
28
]
} | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
166,
174
]
} |
carbachol , a muscarinic receptor agonist and the sodium channel-activating agents , scorpion venom , veratridine , batrachotoxin and aconitine , were shown to stimulate the formation of [ 3h ] inositol phosphates in [ 3h ] inositol-labelled miniprisms , obtained from the cerebral cortex of the mouse . | NA | {
"id": "C0021554",
"name": "inositol phosphates",
"pos": [
194,
213
]
} | {
"id": "C0021547",
"name": "inositol",
"pos": [
224,
232
]
} |
calcium channel blockers such as nickel or cobalt , or the dihydropyridine calcium ( ca2+ ) channel activator bay k 8644 and the calcium channel blocker nifedipine , nimodipine or pn-200 110 had little effect . | NA | {
"id": "C0012315",
"name": "dihydropyridine",
"pos": [
59,
74
]
} | {
"id": "C0028066",
"name": "nifedipine",
"pos": [
153,
163
]
} |
calcium channel blockers such as nickel or cobalt , or the dihydropyridine calcium ( ca2+ ) channel activator bay k 8644 and the calcium channel blocker nifedipine , nimodipine or pn-200 110 had little effect . | NA | {
"id": "C0012315",
"name": "dihydropyridine",
"pos": [
59,
74
]
} | {
"id": "C0028094",
"name": "nimodipine",
"pos": [
166,
176
]
} |
this study evaluated the anticonvulsant activity of saffan in 2 rat models of epilepsy : maximal electroshock and subcutaneous pentylenetetrazol seizures . | NA | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
78,
86
]
} | {
"id": "C0036572",
"name": "seizures",
"pos": [
145,
153
]
} |
changes in jejunal water transport were examined in rats pretreated with bolus i.c.v . doses ( less than or equal to 1 microgram ) of the respective mu- , delta- , or kappa-opiate agonists [ d-ala2 , n-me-phe4 , gly5-ol ] enkephalin ( dago ) , [ d-pen2 , d-pen5 ] enkephalin or u-50488 and infused intravenously with the... | NA | {
"id": "C0525773",
"name": "dago",
"pos": [
235,
239
]
} | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
264,
274
]
} |
naloxone , a mu receptor antagonist , naltrexone , its long acting analog up to doses of 100 nmol , as well as mr1453 , the ( + ) -enantiomer of kappa antagonist mr1452 with no opioid binding properties , did not prevent the hypothermic effect . | NA | {
"id": "C0027358",
"name": "naloxone",
"pos": [
0,
8
]
} | {
"id": "C0027360",
"name": "naltrexone",
"pos": [
38,
48
]
} |
according to the grading of brain tumors as proposed by the who in 1976 , out of 128 ependymomas 83 tumors could be classified as grade ii and 38 as grade iii only seven subependymomas were benign and could be assigned to grade i . | NA | {
"id": "C0014474",
"name": "ependymomas",
"pos": [
85,
96
]
} | {
"id": "C0206725",
"name": "subependymomas",
"pos": [
170,
184
]
} |
venous problems were the major vascular problem in 313 patients , peripheral vascular diseases in 553 and cerebrovascular problems in 562 . | NA | {
"id": "C0042373",
"name": "vascular problem",
"pos": [
31,
47
]
} | {
"id": "C0085096",
"name": "peripheral vascular diseases",
"pos": [
66,
94
]
} |
however , in all cases the dihydropyridine antagonist nifedipine decreased this bay k 8644-enhanced , k+-evoked efflux to below control levels . | NA | {
"id": "C0012315",
"name": "dihydropyridine",
"pos": [
27,
42
]
} | {
"id": "C0028066",
"name": "nifedipine",
"pos": [
54,
64
]
} |
these findings suggest that l-type ca2+ channels are present in both excitatory ( glutamatergic granule cells ) and inhibitory ( gabaergic stellate and basket cells ) neurons in these cultures , and that they appear to be involved in regulating the release of not only neuroactive amino acids , but also some neutral ami... | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
281,
292
]
} | {
"id": "C0301715",
"name": "neutral amino acids",
"pos": [
309,
328
]
} |
the low-threshold ca2+ current of adult and aged rats was also sensitive to nicardipine , a dihydropyridine derivative , same as that of newborn rats . | NA | {
"id": "C0028005",
"name": "nicardipine",
"pos": [
76,
87
]
} | {
"id": "C0012315",
"name": "dihydropyridine",
"pos": [
92,
107
]
} |
the treatment of spinal slices with low concentrations of enzymes and mechanical dissociation yielded isolated neurons that were sensitive to excitatory amino acids ( glutamate , kainate , quisqualate and n-methyl-d-aspartate ( nmda ) , inhibitory amino acids ( gamma-aminobutyric acid ( gaba ) , glycine ) and peptides ... | NA | {
"id": "C0243046",
"name": "excitatory amino acids",
"pos": [
142,
164
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
248,
259
]
} |
the treatment of spinal slices with low concentrations of enzymes and mechanical dissociation yielded isolated neurons that were sensitive to excitatory amino acids ( glutamate , kainate , quisqualate and n-methyl-d-aspartate ( nmda ) , inhibitory amino acids ( gamma-aminobutyric acid ( gaba ) , glycine ) and peptides ... | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
153,
164
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
297,
304
]
} |
viral dna , eb nuclear antigen , and/or early antigens ( ea.d and ea.r ) were detected in 5 npc specimens . | NA | {
"id": "C0069115",
"name": "nuclear antigen",
"pos": [
15,
30
]
} | {
"id": "C0003320",
"name": "antigens",
"pos": [
46,
54
]
} |
in a prospective study , the addition of dipivefrin hydrochloride 0.1 % twice daily to one eye of 32 patients with early primary open-angle glaucoma or ocular hypertension , maintained on a bilateral beta 1- , beta 2-blocker twice daily , resulted in a significant decrease of mean intraocular pressure ( iop ) from 22.7... | NA | {
"id": "C0700488",
"name": "dipivefrin hydrochloride",
"pos": [
41,
65
]
} | {
"id": "C0058415",
"name": "dipivefrin",
"pos": [
440,
450
]
} |
therefore , we investigated the effect of the water-extractable components of smoked tobacco tar condensate ( smoked tobacco tar extract ) on the growth , cytolytic activity , dna synthesis , and gene expression of type 1 herpes simplex virus ( hsv-1 ) . | NA | {
"id": "C0242950",
"name": "water",
"pos": [
46,
51
]
} | {
"id": "C0039315",
"name": "tar",
"pos": [
125,
128
]
} |
the characteristic injuries were compression wedge-shaped fractures , multiple fractures of the vertebrae , comminuted and traumatic spondylolistheses and dislocation fractures . | NA | {
"id": "C0476171",
"name": "comminuted",
"pos": [
108,
118
]
} | {
"id": "C0016658",
"name": "fractures",
"pos": [
167,
176
]
} |
[ characteristics of roentgenologic examination of patients with ununited fractures and pseudarthroses of the femur neck ] . | NA | {
"id": "C0016665",
"name": "ununited",
"pos": [
65,
73
]
} | {
"id": "C0033785",
"name": "pseudarthroses",
"pos": [
88,
102
]
} |
p19 cells are induced to differentiate into neurons , astrocytes and fibroblast-like cells following exposure to retinoic acid ( ra ) . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
4,
9
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
69,
79
]
} |
au-sequence motifs present in the 3 ' untranslated region ( utr ) of many rapidly inducible messenger rnas have been proposed to mediate their selective degradation . | NA | {
"id": "C0600680",
"name": "untranslated region",
"pos": [
38,
57
]
} | {
"id": "C0035696",
"name": "messenger rnas",
"pos": [
92,
106
]
} |
these results do not support anecdotal impressions that the level of reported pain and fear of pain is significantly greater in cancer pain in contrast to non-cancer pain . | NA | {
"id": "C0596240",
"name": "cancer pain",
"pos": [
128,
139
]
} | {
"id": "C0030193",
"name": "pain",
"pos": [
166,
170
]
} |
the results do indicate the importance of emotional expressivity in the modulation of cancer pain where the ability to assess and express emotions was associated with reduced pain . | NA | {
"id": "C0596240",
"name": "cancer",
"pos": [
86,
92
]
} | {
"id": "C0030193",
"name": "pain",
"pos": [
175,
179
]
} |
with ly , gen or tob at 2 x mic the 3 log reduction was observed at 3 h or 4 h , a greater than or equal to 5 log reduction at 24 h : ly and aminoglycosides are the most bactericidal antibiotics against s. aureus . | NA | {
"id": "C0017436",
"name": "gen",
"pos": [
10,
13
]
} | {
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
141,
156
]
} |
the results show that the selecting effect of cefmenoxime is not different from the effect previously observed for cefotaxime . | NA | {
"id": "C0007549",
"name": "cefmenoxime",
"pos": [
46,
57
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
115,
125
]
} |
[ comparison of the in vitro post-antibiotic effect of c14 macrolides ( erythromycin and roxithromycin ) and c16 macrolides ( josamycin and spiramycin ) against staphylococcus aureus ] . | NA | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
72,
84
]
} | {
"id": "C0035891",
"name": "roxithromycin",
"pos": [
89,
102
]
} |
in vitro post-antibiotic effect ( pae ) induced by erythromycin , roxithromycin , josamycin and spiramycin has been compared on staphylococcus aureus . | NA | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
51,
63
]
} | {
"id": "C0035891",
"name": "roxithromycin",
"pos": [
66,
79
]
} |
for erythromycin and roxithromycin delta t ranged from 6 minutes at 1 x mic to 48 minutes at 4 x mic ( average of the six strains at 4 x mic : 33 minutes ) . | NA | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
4,
16
]
} | {
"id": "C0035891",
"name": "roxithromycin",
"pos": [
21,
34
]
} |
in our experimental conditions , paes observed with josamycin and spiramycin ( 16-membered-ring macrolides ) were 2.5 to 3 times longer than those observed with erythromycin and roxithromycin ( 14-membered-ring macrolides ) . | NA | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
161,
173
]
} | {
"id": "C0035891",
"name": "roxithromycin",
"pos": [
178,
191
]
} |
three active macrolides against 100 % of strains were : erythromycin ( mic 50 = 0.25 mg/l - mic 90 = 0.50 mg/l ) , roxithromycin ( mic 50 = 0.50 mg/l - mic 90 = 0.50 mg/l ) and josamycin ( mic 50 = 0.50 mg/l - mic 90 = 1 mg/l ) ; | NA | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
56,
68
]
} | {
"id": "C0035891",
"name": "roxithromycin",
"pos": [
115,
128
]
} |
the in vitro antibacterial activity of miocamycin was compared with four other macrolides ( erythromycin , roxithromycin , josamycin , spiramycin ) and pristinamycin against 90 clinical isolates of branhamella catarrhalis by determination of minimum inhibitory concentrations . | NA | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
92,
104
]
} | {
"id": "C0035891",
"name": "roxithromycin",
"pos": [
107,
120
]
} |
we compared the ability of two beta lactamase inhibitors , clavulanic acid and sulbactam , to reduce the minimal inhibitory concentrations ( mics ) respectively of amoxycillin and ampicillin against fifty strains of haemophilus influenzae producing a beta lactamase . | NA | {
"id": "C0002645",
"name": "amoxycillin",
"pos": [
164,
175
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
180,
190
]
} |
the mics of rosoxacin and pefloxacin are high , but those of ofloxacin ( mic 50 , 2 mg/l ) , fleroxacin ( mic 50 , 2 mg/l ) and ciprofloxacin ( mic 50 , 1 mg/l ) are lower . | NA | {
"id": "C0085161",
"name": "fleroxacin",
"pos": [
93,
103
]
} | {
"id": "C0008809",
"name": "ciprofloxacin",
"pos": [
128,
141
]
} |
in vitro activity of an aminopenicillin ( amoxicillin or ampicillin ) combined with a betalactamase inhibitor ( clavulanic acid or sulbactam , 2 mg/l ) was examined against 39 strains of k. pneumoniae producing 3 types of extended broad spectrum betalactamases ( ctx-1 , shv-3 , shv-4 ) . | NA | {
"id": "C0002645",
"name": "amoxicillin",
"pos": [
42,
53
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
57,
67
]
} |
the sensitivity of the aerobic gram-negative bacteria to ampicillin , clavulanic acid-amoxicillin , cephalothin , gentamicin , pipemidic acid , norfloxacin and co-trimoxazole was tested . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
57,
67
]
} | {
"id": "C0002645",
"name": "amoxicillin",
"pos": [
86,
97
]
} |
these results justify the performance of a clinical trial in the prophylaxis of recurrent uti and the outcome of a bacteriuria associated with indwelling or intermittent bladder catheter . | NA | {
"id": "C0042029",
"name": "of",
"pos": [
38,
40
]
} | {
"id": "C0004659",
"name": "bacteriuria",
"pos": [
115,
126
]
} |
it appears therefore that opc may interact with some components of the fb cell membrane and modify the attachment , proliferation and detachment of these cells . | NA | {
"id": "C0016030",
"name": "fb",
"pos": [
71,
73
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
154,
159
]
} |
finally , the pharmacokinetic profile of dermatan sulphate after intravenous injection in the rabbit , is different from that of standard heparin , and close to that of low molecular weight heparins . | NA | {
"id": "C0019134",
"name": "heparin",
"pos": [
138,
145
]
} | {
"id": "C0019139",
"name": "low",
"pos": [
169,
172
]
} |
the diseases ran their courses in the form of gastroenteritis and enteritis and were marked by a great number of the grave patterns ( 42-46 % ) , mainly in children of the first three years of life , by a high percentage ( 77.5 % ) of the aggravated premorbid status of patients with the grave patterns . | NA | {
"id": "C0017160",
"name": "gastroenteritis",
"pos": [
46,
61
]
} | {
"id": "C0014335",
"name": "enteritis",
"pos": [
66,
75
]
} |
this finding is surprising since the weight of existing theoretical and empirical evidence suggests that subjective preference is derivative of familiarity . | NA | {
"id": "C0037088",
"name": "finding",
"pos": [
5,
12
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
37,
43
]
} |
the unstable resistance was found to be associated with the presence of a repetitive dna in which the repeating unit was a specific segment of the mitochondrial dna . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
85,
88
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
163,
164
]
} |
to study the effects of an atrial premature beat on atrial refractory periods , we investigated 11 patients ( group a ) who were the control group , 12 patients suffering from paroxysmal atrial fibrillation ( group b ) , and 10 patients ( group c ) without arrhythmias but with cardiopathy or cardiomyopathy . | NA | {
"id": "C0003811",
"name": "arrhythmias",
"pos": [
257,
268
]
} | {
"id": "C0018799",
"name": "cardiopathy",
"pos": [
278,
289
]
} |
pacing at this site elicited the clinical tachycardia , whereas pacing at the proximal left ventricular septum induced a right bundle branch block morphology identical to that of a previously recorded spontaneous ventricular tachycardia . | NA | {
"id": "C0039231",
"name": "tachycardia",
"pos": [
42,
53
]
} | {
"id": "C0042514",
"name": "ventricular",
"pos": [
213,
224
]
} |
the npy-induced potentiation of the pressor response to noradrenaline was dose-dependent and extended to the pressor action of adrenaline and angiotensin ii but not to the hypotensions produced by bradykinin or isoproterenol . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
56,
69
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
127,
137
]
} |
splanchnic nerve stimulation at 5 hz caused a preferential increase in adrenal vein ne ( 9-fold ) versus epi ( 7-fold ) levels as compared to baseline , while 50 hz stimulation led to further comparable increases in ne ( 5-fold ) and epi ( 6-fold ) levels . | NA | {
"id": "C0028351",
"name": "ne",
"pos": [
11,
13
]
} | {
"id": "C0014563",
"name": "epi",
"pos": [
234,
237
]
} |
significant increases in adrenal vein da and neuropeptide levels were only observed during 50 hz stimulation , with da showing a 5-fold , me a 2.6-fold and npy a 3-fold increase as compared to 5 hz stimulation , and nt a 3.6-fold increase as compared to baseline . | NA | {
"id": "C0027895",
"name": "neuropeptide",
"pos": [
45,
57
]
} | {
"id": "C0027893",
"name": "npy",
"pos": [
156,
159
]
} |
significant increases in adrenal vein da and neuropeptide levels were only observed during 50 hz stimulation , with da showing a 5-fold , me a 2.6-fold and npy a 3-fold increase as compared to 5 hz stimulation , and nt a 3.6-fold increase as compared to baseline . | NA | {
"id": "C0027895",
"name": "neuropeptide",
"pos": [
45,
57
]
} | {
"id": "C0027930",
"name": "nt",
"pos": [
216,
218
]
} |
in conclusion , these data suggest that in vivo administration of trh may modulate dopaminergic activities by altering , directly or indirectly , dopamine release and reuptake . | NA | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
83,
95
]
} | {
"id": "C0013030",
"name": "dopamine",
"pos": [
146,
154
]
} |
isolated guinea pig ilea were contracted with acetylcholine ( ach ) in the absence and presence of the neuropeptide fmrfamide ( phe-met-arg-phe-nh2 ) . | NA | {
"id": "C0027895",
"name": "neuropeptide",
"pos": [
103,
115
]
} | {
"id": "C0060608",
"name": "fmrfamide",
"pos": [
116,
125
]
} |
the test group was selected out of those poisoned with barbiturates so that a homogeneous toxic agent would be involved and the impact that other toxins may have on the rate of metabolism and excretion eliminated . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
177,
187
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
192,
201
]
} |
ultrastructurally , fibroblasts and myofibroblasts were the main tumor cells in four cases and abundant in two other cases ; | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
20,
31
]
} | {
"id": "C0007634",
"name": "the",
"pos": [
112,
115
]
} |
present results confirm the cellular heterogeneity of mfh of bone , in which fibroblasts and myofibroblasts transformed cells play a histogenetical role , suggesting the existence of close links with classic fibrosarcoma of bone . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
77,
88
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
120,
125
]
} |
histomorphological evaluation of the profile of carbohydrate-binding proteins with specificities to alpha- and beta-glucosides ( maltose , cellobiose ) , alpha-l-fucosides ( l-fucose ) , alpha-d-mannosides ( d-mannose ) , a n-acetylated sugar , present in natural glycoconjugates ( n-acetyl-d-glucosamine ) , two negativ... | NA | {
"id": "C0007004",
"name": "sugar",
"pos": [
237,
242
]
} | {
"id": "C0017906",
"name": "glycoconjugates",
"pos": [
264,
279
]
} |
during the same period , the hospital activity analysis ( haa ) records revealed 174 episodes classified as 'phlebitis or thrombophlebitis ' in 162 patients . | NA | {
"id": "C0031542",
"name": "phlebitis",
"pos": [
109,
118
]
} | {
"id": "C0040046",
"name": "thrombophlebitis",
"pos": [
122,
138
]
} |
enhanced withdrawal of polychlorinated biphenyls : a comparison of colestipol , mineral oil , propylene glycol , and petroleum jelly with or without restricted feeding . | NA | {
"id": "C0026156",
"name": "mineral oil",
"pos": [
80,
91
]
} | {
"id": "C0031262",
"name": "petroleum jelly",
"pos": [
117,
132
]
} |
meat type chickens were fed a commercial mixture of polychlorinated biphenyl ( pcb ) , aroclor 1254 , at 10 ppm for 14 days , then treated for 21 days to hasten the withdrawal of pcb with either mineral oil ( mo ) , petroleum jelly ( pj ) , propylene glycol ( pg ) , or colestipol ( co ) at 5 % of the diet , or at 10 % ... | NA | {
"id": "C0026156",
"name": "mineral oil",
"pos": [
195,
206
]
} | {
"id": "C0031262",
"name": "petroleum jelly",
"pos": [
216,
231
]
} |
when treated with mo , pj , pg , or co alone ( no 50 % fr ) , chickens had body burdens reduced to only 67 to 90 % of control , depending on th compound . | NA | {
"id": "C0026156",
"name": "mo",
"pos": [
18,
20
]
} | {
"id": "C0031262",
"name": "pj",
"pos": [
23,
25
]
} |
thus , feed restriction was necessary for the mo and pj to have their greatest effect . | NA | {
"id": "C0026156",
"name": "mo",
"pos": [
46,
48
]
} | {
"id": "C0031262",
"name": "pj",
"pos": [
53,
55
]
} |
average daily feed intake , hen-day egg production , egg weight , egg specific gravity , and body weight change were determined during each experiment . | NA | {
"id": "C0005910",
"name": "weight",
"pos": [
57,
63
]
} | {
"id": "C0005911",
"name": "body weight change",
"pos": [
93,
111
]
} |
to investigate the effect of l-neutral amino acids on tissue levels of methyl mercury in the adult animal , rats were infused into the external jugular vein with solutions containing a ) 0.05 mm 203hg-mehgcl and saline , b ) 0.05 mm 203hg-mghgcl-0.1 mm l-cysteine , c ) 0.05 mm 203hg-mehgcl-0.1 mm l-cysteine-0.1 mm l-cy... | NA | {
"id": "C0301715",
"name": "neutral amino acids",
"pos": [
31,
50
]
} | {
"id": "C0010654",
"name": "l-cysteine",
"pos": [
428,
438
]
} |
demethoxydaunorubicin was compared to other anthracyclines ( daunorubicin , doxorubicin , epirubicin ) on its ability to generate free oxygen radicals when mixed with fe2+ in solution and on its ability to reduce clonogenic survival of fibroblasts in culture . | NA | {
"id": "C0011015",
"name": "daunorubicin",
"pos": [
9,
21
]
} | {
"id": "C0013089",
"name": "doxorubicin",
"pos": [
76,
87
]
} |
demethoxydaunorubicin was compared to other anthracyclines ( daunorubicin , doxorubicin , epirubicin ) on its ability to generate free oxygen radicals when mixed with fe2+ in solution and on its ability to reduce clonogenic survival of fibroblasts in culture . | NA | {
"id": "C0013089",
"name": "doxorubicin",
"pos": [
76,
87
]
} | {
"id": "C0014582",
"name": "epirubicin",
"pos": [
90,
100
]
} |
( 3 ) ach output was inhibited by infusion of 100 mumol/l naloxone or 10 mumol/l naltrexone , but was not affected by lower concentrations of either antagonist . | NA | {
"id": "C0027358",
"name": "naloxone",
"pos": [
58,
66
]
} | {
"id": "C0027360",
"name": "naltrexone",
"pos": [
81,
91
]
} |
the diagnostic information on peripheral airway obstruction is contained in both components r ( f ) and x ( f ) of the respiratory impedance ; | NA | {
"id": "C0016330",
"name": "components",
"pos": [
81,
91
]
} | {
"id": "C0016327",
"name": "f",
"pos": [
113,
114
]
} |
the cd spectra of other mutant proteins also differed from that of the wild-type protein , despite the fact that the substituted residues at position 49 were not aromatic . | NA | {
"id": "C1564139",
"name": "mutant proteins",
"pos": [
24,
39
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
81,
88
]
} |
for 10 mutant proteins substituted by ile , ala , leu , met , val , cys , pro , ser , his , or gly , their cd values of bands ( due to tyr residues ) decreased in comparison with those of the wild-type protein . | NA | {
"id": "C1564139",
"name": "mutant proteins",
"pos": [
7,
22
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
202,
209
]
} |
in the second group , three mutant proteins were substituted by lys , gln , or asn , and the cd values of tyrosyl bands increased compared to those of the wild-type proteins . | NA | {
"id": "C1564139",
"name": "mutant proteins",
"pos": [
28,
43
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
165,
173
]
} |
in the third group , the cd values of tyrosyl bands of two mutant proteins substituted by asp or thr were similar to those of the wild-type protein , except for one band at 276.5 nm . | NA | {
"id": "C1564139",
"name": "mutant proteins",
"pos": [
59,
74
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
140,
147
]
} |
the sequenced region was amplified by the polymerase chain reaction and subsequently transcribed and translated using both in vivo and in vitro systems , and the resultant gene product characterized to show that the gene encodes the type i isoform of pyruvate kinase . | NA | {
"id": "C0033684",
"name": "gene",
"pos": [
172,
176
]
} | {
"id": "C0597298",
"name": "isoform",
"pos": [
240,
247
]
} |
to determine the structure of the high molecular weight , growth hormone-dependent complex between the insulin-like growth factors ( igf-i and igf-ii ) and their binding proteins in human serum , we have reconstituted the complex from its purified component proteins and analyzed it by gel electrophoresis and autoradiog... | NA | {
"id": "C0037657",
"name": "insulin-like growth factors",
"pos": [
103,
130
]
} | {
"id": "C0021665",
"name": "igf-i",
"pos": [
143,
148
]
} |
to determine the structure of the high molecular weight , growth hormone-dependent complex between the insulin-like growth factors ( igf-i and igf-ii ) and their binding proteins in human serum , we have reconstituted the complex from its purified component proteins and analyzed it by gel electrophoresis and autoradiog... | NA | {
"id": "C0037657",
"name": "insulin-like growth factors",
"pos": [
103,
130
]
} | {
"id": "C0021666",
"name": "igf-ii",
"pos": [
143,
149
]
} |
the proteins tested in reconstitution mixtures were an acid-labile mr 84,000-86,000 glycoprotein doublet ( alpha subunit ) , an acid-stable mr 47,000-53,000 glycoprotein doublet with igf-binding activity ( bp-53 or beta subunit ) , and igf-i or igf-ii ( gamma subunit ) . | NA | {
"id": "C0037657",
"name": "igf",
"pos": [
183,
186
]
} | {
"id": "C0021665",
"name": "igf-i",
"pos": [
245,
250
]
} |
the proteins tested in reconstitution mixtures were an acid-labile mr 84,000-86,000 glycoprotein doublet ( alpha subunit ) , an acid-stable mr 47,000-53,000 glycoprotein doublet with igf-binding activity ( bp-53 or beta subunit ) , and igf-i or igf-ii ( gamma subunit ) . | NA | {
"id": "C0037657",
"name": "igf",
"pos": [
183,
186
]
} | {
"id": "C0021666",
"name": "igf-ii",
"pos": [
245,
251
]
} |
when expressed as protein , these mrnas encode ca2+ pump isoforms that differ in their c-terminal regulatory domains . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
18,
25
]
} | {
"id": "C0597298",
"name": "isoforms",
"pos": [
57,
65
]
} |
photoformation of metalloporphyrin cations in a lipid bilayer increases the ionic currents of negative and decreases those of positive hydrophobic ions . | NA | {
"id": "C0007447",
"name": "cations",
"pos": [
35,
42
]
} | {
"id": "C0022023",
"name": "ions",
"pos": [
147,
151
]
} |
the two susceptibility markers of each clinical form of ms act additively in determining the genetic susceptibility , as the relative risks for individuals carrying both markers roughly equal the sum of respective risks . | NA | {
"id": "C0012655",
"name": "susceptibility",
"pos": [
8,
22
]
} | {
"id": "C0314657",
"name": "genetic",
"pos": [
93,
100
]
} |
the observed immunogenetic heterogeneity between the different clinical forms of ms favors the hypothesis that primarily chronic progressive ms and relapsing/remitting ms are two distinct disease entities . | NA | {
"id": "C0026769",
"name": "ms",
"pos": [
75,
77
]
} | {
"id": "C0393665",
"name": "chronic progressive ms",
"pos": [
121,
143
]
} |
the observed immunogenetic heterogeneity between the different clinical forms of ms favors the hypothesis that primarily chronic progressive ms and relapsing/remitting ms are two distinct disease entities . | NA | {
"id": "C0026769",
"name": "ms",
"pos": [
75,
77
]
} | {
"id": "C0751967",
"name": "relapsing/remitting ms",
"pos": [
148,
170
]
} |
some of these antibodies are also known to suppress , isotype-specifically , the interleukin 4-promoted ige synthesis from peripheral blood mononuclear cells or the spontaneous synthesis of ige by b cells isolated from atopic donors . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
14,
24
]
} | {
"id": "C0021017",
"name": "isotype",
"pos": [
54,
61
]
} |
the epitope of mhm6 , an anti-f epsilon rii monoclonal antibody delivering an epitope-restricted growth-promoting effect on b cells , is also located within the lectin-like domain . | NA | {
"id": "C0003316",
"name": "epitope",
"pos": [
4,
11
]
} | {
"id": "C0282581",
"name": "epitope",
"pos": [
78,
85
]
} |
the target antigen is atypical , however , in its ability to directly bind and activate the t cells in the absence of self mhc , presumably by abundant and regularly repeated antigenic epitopes . | NA | {
"id": "C0003320",
"name": "antigenic",
"pos": [
175,
184
]
} | {
"id": "C0003316",
"name": "epitopes",
"pos": [
185,
193
]
} |
astrocytomas , including glioblastoma multiforme , represent the most frequent and deadly primary neoplasms of the human nervous system . | NA | {
"id": "C0004114",
"name": "astrocytomas",
"pos": [
0,
12
]
} | {
"id": "C0017636",
"name": "glioblastoma multiforme",
"pos": [
25,
48
]
} |
isolated adult guinea pig thalamic ( dorsal lateral geniculate ) neurons exhibited low-threshold spikes that could be blocked by low concentrations of nickel but were unaffected by the dihydropyridine nimodipine . | NA | {
"id": "C0012315",
"name": "dihydropyridine",
"pos": [
185,
200
]
} | {
"id": "C0028094",
"name": "nimodipine",
"pos": [
201,
211
]
} |
in this paper , the biosynthesis and release of l-beta-3,4-dihydroxyphenylalanine ( l-dopa ) and dopamine were analyzed in three heterologous cell lines after retroviral-mediated gene transfer of tyrosine hydroxylase ( ec 1.14.16.2 ) , the rate-limiting enzyme in catecholamine synthesis . | NA | {
"id": "C0013023",
"name": "dihydroxyphenylalanine",
"pos": [
59,
81
]
} | {
"id": "C0023570",
"name": "l-dopa",
"pos": [
84,
90
]
} |
in this paper , the biosynthesis and release of l-beta-3,4-dihydroxyphenylalanine ( l-dopa ) and dopamine were analyzed in three heterologous cell lines after retroviral-mediated gene transfer of tyrosine hydroxylase ( ec 1.14.16.2 ) , the rate-limiting enzyme in catecholamine synthesis . | NA | {
"id": "C0013023",
"name": "dihydroxyphenylalanine",
"pos": [
59,
81
]
} | {
"id": "C0007412",
"name": "catecholamine",
"pos": [
264,
277
]
} |
high levels of rtr beta transcripts in the anterior pituitary and the parvocellular part of the paraventricular hypothalamic nucleus suggest rtr beta gene products may mediate thyroid hormone feedback regulation of thyroid-stimulating hormone and thyrotropin-releasing hormone . | NA | {
"id": "C0032016",
"name": "anterior pituitary",
"pos": [
43,
61
]
} | {
"id": "C0040160",
"name": "thyroid hormone",
"pos": [
176,
191
]
} |
these differences in morphology have been analyzed quantitatively for nerve cells growing on the plant lectin con a , on extracellular matrix extract ( ecm ) containing laminin , and on patterned substrates . | NA | {
"id": "C0304052",
"name": "plant lectin",
"pos": [
97,
109
]
} | {
"id": "C0009630",
"name": "con a",
"pos": [
110,
115
]
} |
a predominance of glycated crystallins , gamma crystallin in particular , was noticed in the hmw aggregates . | NA | {
"id": "C0010422",
"name": "crystallins",
"pos": [
27,
38
]
} | {
"id": "C0017030",
"name": "gamma",
"pos": [
41,
46
]
} |
the role of the complement system in the pathogenesis of multiple organ failure in shock . | NA | {
"id": "C0026766",
"name": "multiple organ failure",
"pos": [
57,
79
]
} | {
"id": "C0036974",
"name": "shock",
"pos": [
83,
88
]
} |
using a rat model of endotoxin shock , the fall in mean arterial blood pressure to an intravenous injection of lipopolysaccharide from e. coli was significantly attenuated by the b4148 as compared to controls . | NA | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
21,
30
]
} | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
111,
129
]
} |
the effect of fish oil-derived omega-3 ( omega-3 ) fatty acids on anaphylaxis , arthus and delayed type hypersensitivity reactions in mice has been investigated . | NA | {
"id": "C0016157",
"name": "fish oil",
"pos": [
14,
22
]
} | {
"id": "C0015689",
"name": "omega-3",
"pos": [
41,
48
]
} |
synthesis of prostaglandin e2 by peritoneal macrophages was significantly inhibited in the animals fed omega-3 fatty acid-enriched fish oil , while leukotriene b4 production was not affected . | NA | {
"id": "C0015689",
"name": "omega-3",
"pos": [
103,
110
]
} | {
"id": "C0016157",
"name": "fish oil",
"pos": [
131,
139
]
} |
we studied the acute intravascular effects of some of these unsaturated fatty acids ( i.e. , eicosapentaenoic acid , epa ; docosahexaenoic acid , dha ) along with omega-6 unsaturated fatty acids , ( i.e. , linoleic and linolenic acid ) in splanchnic artery occlusion ( sao ) shock in rats . | NA | {
"id": "C0015690",
"name": "unsaturated fatty acids",
"pos": [
60,
83
]
} | {
"id": "C0133860",
"name": "omega-6",
"pos": [
163,
170
]
} |
epa and dha treated sao rats also exhibited lower plasma activities of the lysosomal protease , cathepsin d , free amino-nitrogen compounds , and the cardiotoxic peptide , myocardial depressant factor . | NA | {
"id": "C0030956",
"name": "peptide",
"pos": [
162,
169
]
} | {
"id": "C0027047",
"name": "myocardial depressant factor",
"pos": [
172,
200
]
} |
the motor effects of l-glu were blocked by l-glutamic acid diethyl ester ( gdee ) and by a larger sedative dose of 2-amino-5-phosphonopentanoic acid ( ap5 ) , but not by haloperidol , gaba , glycine ( gly ) , or a smaller nonsedative dose of ap5 . | NA | {
"id": "C0002520",
"name": "amino",
"pos": [
117,
122
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
191,
198
]
} |
since benzodiazepines can also cause hypothermia , colonic temperatures were measured in mice after administration of chlordiazepoxide ( cdp ) and these two brain peptides . | NA | {
"id": "C0005064",
"name": "benzodiazepines",
"pos": [
6,
21
]
} | {
"id": "C0008188",
"name": "chlordiazepoxide",
"pos": [
118,
134
]
} |
neurotensin ( nt ) is a neuropeptide and putative neurotransmitter that has been shown to exert a variety of effects on digestive and ingestive processes . | NA | {
"id": "C0027930",
"name": "neurotensin",
"pos": [
0,
11
]
} | {
"id": "C0027895",
"name": "neuropeptide",
"pos": [
24,
36
]
} |
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