text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
fluorescence methods , particularly at low temperatures where the bands are better resolved and the fluorescence yields are significantly greater than at room temperature , can also be used to distinguish covalent dna adducts derived from the binding of ( + ) -bpde and ( - ) -bpde to native double-stranded dna . | NA | {
"id": "C0242958",
"name": "dna adducts",
"pos": [
214,
225
]
} | {
"id": "C0012854",
"name": "double-stranded dna",
"pos": [
292,
311
]
} |
plasma noradrenaline ( na ) , adrenaline ( a ) and corticosterone ( cs ) increases were determined in individual rats subjected to either 20 regularly or irregularly scheduled white-noise stimulations ( 4 min , 100 dba ) . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
7,
20
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
30,
40
]
} |
sucrose gave the largest response among the disaccharides , while there was no significant difference between the monosaccharides . | NA | {
"id": "C0038636",
"name": "sucrose",
"pos": [
0,
7
]
} | {
"id": "C0012611",
"name": "disaccharides",
"pos": [
44,
57
]
} |
plasma noradrenaline ( na ) , adrenaline ( a ) , corticosterone ( cs ) and glucose concentrations were determined in blood sampled via a cardiac catheter from freely moving male rats under ad lib fed and 24 hr food deprived conditions using a repeated measures within-subject design . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
7,
20
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
30,
40
]
} |
test birds learned to discriminate amyl acetate vs. turpentine essence , jasmine essence vs. lavender essence , eucalyptus essence vs. no odor , beta-ionone vs. no odor , carvone vs. eucalyptol . | NA | {
"id": "C0041411",
"name": "turpentine",
"pos": [
52,
62
]
} | {
"id": "C0028910",
"name": "essence",
"pos": [
123,
130
]
} |
maintenance of a patent ductus arteriosus by means of prostaglandins enables the surgical correction of a congenital heart defect in infants to be postponed until a phase of development when the operation hazards are smaller . | NA | {
"id": "C0013274",
"name": "patent ductus arteriosus",
"pos": [
17,
41
]
} | {
"id": "C0018798",
"name": "the",
"pos": [
191,
194
]
} |
concentrations of asp , glu , gly , gaba and gln were studied in the ventral and dorsal horns of the rabbit spinal cord after ligation of the abdominal aorta . | NA | {
"id": "C0061472",
"name": "glu",
"pos": [
24,
27
]
} | {
"id": "C0017797",
"name": "gln",
"pos": [
45,
48
]
} |
a dna/membrane complex extracted from a miniplasmid derivative of the broad host range plasmid rk2 cultured in escherichia coli capable of synthesizing new plasmid supercoiled dna in vitro was treated with antibodies that were made against or reacted with the dnaa and dnak host-encoded proteins , respectively . | NA | {
"id": "C0000702",
"name": "a dna",
"pos": [
0,
5
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
269,
272
]
} |
methylenedioxymethamphetamine ( mdma ) is a phenylethylamine with a chemical structure that resembles both the amphetamines and mescaline and has both stimulant and perception altering properties . | NA | {
"id": "C0115471",
"name": "methylenedioxymethamphetamine",
"pos": [
0,
29
]
} | {
"id": "C0002667",
"name": "amphetamines",
"pos": [
111,
123
]
} |
rimmed and laminated stones with foci of high attenuation dissolved significantly to 5 % or less of the original weight , a finding indicating that such foci do not preclude dissolution . | NA | {
"id": "C0005910",
"name": "weight",
"pos": [
113,
119
]
} | {
"id": "C0037088",
"name": "finding",
"pos": [
124,
131
]
} |
gadopentetate dimeglumine ( gadolinium diethylenetriaminepentaacetic acid [ dtpa ] ) was administered prospectively to 500 consecutive children and adults referred for routine cranial magnetic resonance ( mr ) imaging over a 4-month period . | NA | {
"id": "C0060934",
"name": "gadopentetate dimeglumine",
"pos": [
0,
25
]
} | {
"id": "C0060933",
"name": "gadolinium diethylenetriaminepentaacetic acid",
"pos": [
28,
73
]
} |
the uptake of ( 3 ) h-labelled ouabain , digoxin , digitoxin and digitoxigenin was studied in guinea-pig isolated atria , suspended in circulating blood . | NA | {
"id": "C0012258",
"name": "digitoxin",
"pos": [
51,
60
]
} | {
"id": "C0012257",
"name": "digitoxigenin",
"pos": [
65,
78
]
} |
the time course of the positive chronotropic action of acetylcholine resembled that produced by adrenaline or noradrenaline.4 . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
96,
106
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
110,
123
]
} |
the occurrence of diester waxes in human vernix caseosa and in hair lipids of common laboratory animals . | NA | {
"id": "C0043076",
"name": "waxes",
"pos": [
26,
31
]
} | {
"id": "C0023779",
"name": "lipids",
"pos": [
68,
74
]
} |
the particulate r ( 3 ) fraction , which possessed the l-malate oxidoreductase , carried out the cyanide-sensitive oxidation of l-malate , d-lactate , reduced nicotinamide adenine dinucleotide and nicotinamide adenine dinucleotide phosphate , succinate , cytochrome c , tetramethyl-p-phenylenediamine , and p-phenylenedi... | NA | {
"id": "C0031468",
"name": "phenylenediamine",
"pos": [
284,
300
]
} | {
"id": "C0048678",
"name": "p-phenylenediamine",
"pos": [
307,
325
]
} |
limitation for isoleucine and valine was accomplished by the use of peptides containing these amino acids conjugated with glycine as nutritional supplements for auxotrophs . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
94,
105
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
122,
129
]
} |
limitation for any of the three branched-chain amino acids led to derepression of the isoleucine-valine biosynthetic pathway . | NA | {
"id": "C0002521",
"name": "branched-chain amino acids",
"pos": [
32,
58
]
} | {
"id": "C0022192",
"name": "isoleucine",
"pos": [
86,
96
]
} |
limitation for any of the three branched-chain amino acids led to derepression of the isoleucine-valine biosynthetic pathway . | NA | {
"id": "C0002521",
"name": "branched-chain amino acids",
"pos": [
32,
58
]
} | {
"id": "C0042285",
"name": "valine",
"pos": [
97,
103
]
} |
components of cytochrome system and purification and some properties of c-type cytochromes of a denitrifying bacterium , pseudomonas stutzeri . | NA | {
"id": "C0010798",
"name": "cytochrome",
"pos": [
14,
24
]
} | {
"id": "C1256752",
"name": "c-type",
"pos": [
72,
78
]
} |
[ on the possibilities of conditioning , in man , some types of epileptic discharges and seizures of a reflex nature ] . | NA | {
"id": "C0014544",
"name": "epileptic",
"pos": [
64,
73
]
} | {
"id": "C0036572",
"name": "seizures",
"pos": [
89,
97
]
} |
radioactively labelled carbachol , acetylcholine and decamethonium do not enter the cells on the choline carrier.5 . | NA | {
"id": "C0006945",
"name": "carbachol",
"pos": [
23,
32
]
} | {
"id": "C0008405",
"name": "choline",
"pos": [
97,
104
]
} |
normal adrenal sensitivity to corticotrophin returned more rapidly than normal pituitary corticotrophic function , suggesting that the initial impairment of hpa function was due both to reduced responsiveness of the adrenal gland to corticotrophin and failure of the pituitary gland to secrete the hormone . | NA | {
"id": "C0032002",
"name": "hpa",
"pos": [
157,
160
]
} | {
"id": "C0020635",
"name": "failure",
"pos": [
252,
259
]
} |
although it was possible to measure noradrenaline and normetanephrine by the same method in pure solution , crude tissue extracts could not be used , despite their suitability for estimating the glycol metabolites . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
36,
49
]
} | {
"id": "C0028385",
"name": "normetanephrine",
"pos": [
54,
69
]
} |
the effects on the metabolism of brain amines of cpz ( 5 mg/kg ) , doses which the serial sampling of c.s.f . experiments had indicated as producing maximal and minimal effects on dopamine metabolism in brain tissue , were studied by estimating the concentrations of adrenaline , noradrenaline , dopamine , metanephrine ... | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
267,
277
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
280,
293
]
} |
the effects on the metabolism of brain amines of cpz ( 5 mg/kg ) , doses which the serial sampling of c.s.f . experiments had indicated as producing maximal and minimal effects on dopamine metabolism in brain tissue , were studied by estimating the concentrations of adrenaline , noradrenaline , dopamine , metanephrine ... | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
267,
277
]
} | {
"id": "C0025562",
"name": "metanephrine",
"pos": [
307,
319
]
} |
responses to catecholamines ( adrenaline , noradrenaline , nordefrine ) were enhanced by 17beta-oestradiol , progesterone and desoxycorticosterone in untreated and reserpine pretreated aortic strips . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
30,
40
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
43,
56
]
} |
adrenaline , noradrenaline and phenylephrine were directly acting agonists , their ed50 values being 7.1 x 10 ( -6 ) m , 1.5 x 10 ( -5 ) m and 2.7 x 10 ( -5 ) m , respectively.3 . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
0,
10
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
13,
26
]
} |
pretreatment with reserpine had no influence on the contractions caused by adrenaline , noradrenaline and phenylephrine but abolished or greatly reduced the contractions caused by dopamine . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
75,
85
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
88,
101
]
} |
pronethalol ( 6.8 x 10 ( -5 ) m ) reversed the alpha-receptor blockade by dibenamine , ergotamine and phentolamine of responses to adrenaline , noradrenaline and phenylephrine ; | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
131,
141
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
144,
157
]
} |
investigation of the kinins produced by enzymes in rabbit and human polymorphonuclear ( pmn ) cells has demonstrated the formation of a kinin that differs from bradykinin and other known mammalian kinins in its pharmacological properties , molecular weight , and amino-terminal end group . | NA | {
"id": "C0006100",
"name": "bradykinin",
"pos": [
160,
170
]
} | {
"id": "C0022714",
"name": "kinins",
"pos": [
197,
203
]
} |
studies on the intestinal resorption of fats , the intermediary lipid metabolism and the lipase activity in obese persons . | NA | {
"id": "C0015677",
"name": "fats",
"pos": [
40,
44
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
64,
69
]
} |
the effects of hypercapnia and hypocapnia upon the cerebrospinal fluid lactate and pyruvate concentrations and upon the lactate , pyruvate , atp , adp , phosphocreatine and creatine concentrations of cat brain tissue . | NA | {
"id": "C0031634",
"name": "phosphocreatine",
"pos": [
153,
168
]
} | {
"id": "C0010286",
"name": "creatine",
"pos": [
173,
181
]
} |
progesterone , 20 alpha-hydroxy-delta 4-pregnen-3-one , androstenedione and corticosterone content of portal vein and vena caval blood in rats bearing ovarian grafts to the spleen . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
0,
12
]
} | {
"id": "C0012311",
"name": "20 alpha-hydroxy",
"pos": [
15,
31
]
} |
[ on rupture of the uterus in pregnancy and labor in the third trimester in women with prior cesarean section ] . | NA | {
"id": "C0032961",
"name": "pregnancy",
"pos": [
30,
39
]
} | {
"id": "C0032981",
"name": "third trimester",
"pos": [
57,
72
]
} |
comparison in conscious goats of the effects of epinephrine , norepinephrine , and tyramine on blood pressure . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
48,
59
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
62,
76
]
} |
in discussing the possible significance of this observation , it is suggested that if this site were directed so that cation was actively pumped from golgi cisternae into cytoplasm ( and if there were differential water and ion permeabilities in various parts of the endoplasmic reticulum-golgi system ) , then such a pu... | NA | {
"id": "C0007447",
"name": "cation",
"pos": [
118,
124
]
} | {
"id": "C0022023",
"name": "ion",
"pos": [
392,
395
]
} |
[ necrotic purpura associated with varicella with drug hypersensitivity coagulopathy related to a schwartzman-sanarelli phenomenon . therapeutic consequences ] . | NA | {
"id": "C0034150",
"name": "purpura",
"pos": [
11,
18
]
} | {
"id": "C0005779",
"name": "coagulopathy",
"pos": [
72,
84
]
} |
the levels of fibrin , fibrinogen degradation products ( f.d.p . ) in the serum were investigated in normal pregnancy and parturition , after caesarean section , and in patients with abruptio placentae , eclampsia , intrauterine death , and post-partum haemorrhage . | NA | {
"id": "C0015982",
"name": "fibrin",
"pos": [
14,
20
]
} | {
"id": "C0163275",
"name": "fibrinogen degradation products",
"pos": [
23,
54
]
} |
the doublet pattern of the nucleic acid of oncogenic and non oncogenic viruses and its relationship to that of mammalian dna . | NA | {
"id": "C0028606",
"name": "nucleic acid",
"pos": [
27,
39
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
121,
124
]
} |
[ contribution to the analysis of chlorothiazide and hydrochlorothiazide . ii . bromatometric and bromchlorometric determination of hydrochlorothiazide ] . | NA | {
"id": "C0008273",
"name": "chlorothiazide",
"pos": [
34,
48
]
} | {
"id": "C0020261",
"name": "hydrochlorothiazide",
"pos": [
132,
151
]
} |
synthesis of cerebroside by brain from uridine diphosphate galactose and ceramide containing hydroxy fatty acid . | NA | {
"id": "C0007805",
"name": "cerebroside",
"pos": [
13,
24
]
} | {
"id": "C0007745",
"name": "ceramide",
"pos": [
73,
81
]
} |
the influence of catecholamines ( epinephrine and norepinephrine ) and thiamine , injected simultaneously , on the iris of bufo viridis . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
34,
45
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
50,
64
]
} |
[ studies on the stability of drugs . xix . stability of benzothiadiazines . ( 10 ) . studies on the hydrolysis of chlorothiazide in mixed solvents ] . | NA | {
"id": "C0005084",
"name": "benzothiadiazines",
"pos": [
57,
74
]
} | {
"id": "C0008273",
"name": "chlorothiazide",
"pos": [
115,
129
]
} |
direct measurement of ffa fractional oxidation as well as ffa uptake , exclusive of possible simultaneous ffa release , would appear necessary in studies concerned with human myocardial ffa metabolism . | NA | {
"id": "C0015684",
"name": "ffa",
"pos": [
22,
25
]
} | {
"id": "C0015688",
"name": "ffa",
"pos": [
186,
189
]
} |
determinations of urinary clearances of beta ( 2 ) -microglobulin and albumin in four healthy subjects and 11 patients indicated that increased excretions of the two proteins were associated with increased clearances . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
70,
77
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
166,
174
]
} |
three immunochemically and electrophoretically distinct lipoproteins , lp-a , lp-b , and lp-x , ( 1 ) were isolated from the low density lipoprotein fraction ( 1.006-1.063 g/ml ) in plasma from patients with biliary obstruction by a separation procedure which combines ultracentrifugation , heparin precipitation , and e... | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
56,
68
]
} | {
"id": "C0065058",
"name": "lp-a",
"pos": [
71,
75
]
} |
this method , here described , permits the quantitative determination of individual plasma lipoprotein families on the basis of their protein moieties , rather than on the basis of their lipid moieties or density . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
91,
102
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
187,
192
]
} |
the significant correlations between per cent standard body weight and fatty acids in americans were positive for palmitic and negative for lauric and stearic acids , and in japanese , negative for myristic acid . | NA | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
71,
82
]
} | {
"id": "C0038230",
"name": "stearic acids",
"pos": [
151,
164
]
} |
with norepinephrine and epinephrine infusions , the isoproterenol dilatations were less ( 65.1+/-9.0 and 55.2+/-7.2 , respectively ) , consistent with the stimulant action of these agents on both alpha and beta receptors ; | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
5,
19
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
24,
35
]
} |
such action was confirmed by comparing the responses to nerve stimulation and infusions of norepinephrine and epinephrine before and after betareceptor blockade . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
91,
105
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
110,
121
]
} |
the venoconstriction caused by sympathetic stimulation and by infusions of norepinephrine and epinephrine was greatly enhanced by cooling the vein ( decreasing perfusate temperature ) , but the dilating action of isoproterenol appeared to be insensitive to changes in temperature . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
75,
89
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
94,
105
]
} |
when isotonic solutions containing nacl and/or mannitol were infused into the colon : ( a ) a direct linear relationship between luminal sodium concentration ( in the range of 23-150 meq/liter ) and rate of net water , sodium , and chloride absorption was found . | NA | {
"id": "C0037494",
"name": "nacl",
"pos": [
35,
39
]
} | {
"id": "C0008203",
"name": "chloride",
"pos": [
232,
240
]
} |
[ on the biosynthesis of vinca as well as cinchona alkaloids : incorporation of swerosids in reserpinine and quinine ] . | NA | {
"id": "C0008792",
"name": "cinchona alkaloids",
"pos": [
42,
60
]
} | {
"id": "C0034417",
"name": "quinine",
"pos": [
109,
116
]
} |
[ myocardial retention of free fatty acids in man : study of individual fatty acids and action of various pharmacodynamic agents ] . | NA | {
"id": "C0015688",
"name": "free fatty acids",
"pos": [
26,
42
]
} | {
"id": "C0015684",
"name": "fatty",
"pos": [
72,
77
]
} |
a single , functional , mitotically quiescent chondrocyte may be induced to reenter the mitotic cyde , and produce a progeny of over 10 ( 11 ) cells . | NA | {
"id": "C0225369",
"name": "chondrocyte",
"pos": [
46,
57
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
143,
148
]
} |
6-thiopurines as substrates and inhibitors of purine oxidases : a pathway for conversion of azathioprine into 6-thiouric acid without release of 6-mercaptopurine . | NA | {
"id": "C0000618",
"name": "substrates",
"pos": [
17,
27
]
} | {
"id": "C0004482",
"name": "azathioprine",
"pos": [
92,
104
]
} |
a method for the fractionation of escherichia coli rna 's into transfer rna and ribosomal rna 's using zn2+ or cd2+ as precipitant . | NA | {
"id": "C0035668",
"name": "rna 's",
"pos": [
51,
57
]
} | {
"id": "C0035711",
"name": "transfer rna",
"pos": [
63,
75
]
} |
a method for the fractionation of escherichia coli rna 's into transfer rna and ribosomal rna 's using zn2+ or cd2+ as precipitant . | NA | {
"id": "C0035668",
"name": "rna 's",
"pos": [
51,
57
]
} | {
"id": "C0035701",
"name": "ribosomal rna 's",
"pos": [
80,
96
]
} |
nucleotide sequence of oligonucleotides derived from escherichia coli valine transfer rna by ribonuclease t1 digestion : comparison of the sequences neighboring 3'- and 5'-terminals and anticodon region of escherichia coli valine transfer rna with those of yeast valine transfer rna . | NA | {
"id": "C0003284",
"name": "anticodon",
"pos": [
186,
195
]
} | {
"id": "C0035711",
"name": "transfer rna",
"pos": [
270,
282
]
} |
studies on the sensitivity of the iris of amphibians ( hyla arborea and bufo viridis ) to epinephrine and norepinephrine . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
90,
101
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
106,
120
]
} |
mucocutaneous pigmentation and intestinal polyposis ( peutz-jeghers syndrome ) in a family of iraqi jews with polycystic kidney disease . | NA | {
"id": "C1257915",
"name": "intestinal polyposis",
"pos": [
31,
51
]
} | {
"id": "C0031269",
"name": "peutz-jeghers syndrome",
"pos": [
54,
76
]
} |
since a significant fraction of the wall radioactivity was in the form of tg , the decreased transport of wall lipids was attributed to an impairment of chylomicron completion due to inhibition of either the synthesis of chylomicron apoprotein or the association of preformed tg with the protein moiety of chylomicrons . | NA | {
"id": "C0003601",
"name": "apoprotein",
"pos": [
233,
243
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
288,
295
]
} |
the latter observation suggests that pentagastrin ( and probably gastrin ) releases secretin by a direct humoral effect which is later fortified by the arrival of gastric acid in the duodenum . | NA | {
"id": "C0030859",
"name": "pentagastrin",
"pos": [
37,
49
]
} | {
"id": "C0017151",
"name": "gastrin",
"pos": [
65,
72
]
} |
plasma transport of free fatty acids ( ffa ) and triglyceride fatty acids ( tgfa ) was studied in seven subjects with normal lipid metabolism , one case of total lipodystrophy , and one case of familial hyperlipemia ( type v ) . | NA | {
"id": "C0015688",
"name": "free fatty acids",
"pos": [
20,
36
]
} | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
62,
73
]
} |
computer techniques were used to evaluate a series of multicompartmental models , and a general model is proposed that yields optimum fitting of experimental data for both ffa and tgfa . | NA | {
"id": "C0015688",
"name": "ffa",
"pos": [
172,
175
]
} | {
"id": "C0015684",
"name": "tgfa",
"pos": [
180,
184
]
} |
in two normal subjects given injections of autologous lipoproteins labeled in vitro with triolein- ( 14 ) c and simultaneously given oleic acid- ( 3 ) h , it was shown that the time course for the disappearance of the tgfa in the in vitro labeled samples conformed almost exactly to that of the physiologically labeled l... | NA | {
"id": "C0015684",
"name": "tgfa",
"pos": [
218,
222
]
} | {
"id": "C0015688",
"name": "ffa",
"pos": [
362,
365
]
} |
radioactivity appeared in the plasma ffa fraction at a significant rate after injection of plasma labeled in vitro with tgfa . | NA | {
"id": "C0015688",
"name": "ffa",
"pos": [
37,
40
]
} | {
"id": "C0015684",
"name": "tgfa",
"pos": [
120,
124
]
} |
it was estimated that as much as 50 % of the total tgfa transported underwent rapid and rather direct conversion to ffa in the two normal subjects studied this way . | NA | {
"id": "C0015684",
"name": "tgfa",
"pos": [
51,
55
]
} | {
"id": "C0015688",
"name": "ffa",
"pos": [
116,
119
]
} |
the kinetic data suggest that such conversion of tgfa to ffa was not preceded by any extensive dilution , such as would result from complete mixing with tissue triglyceride stores . | NA | {
"id": "C0015684",
"name": "tgfa",
"pos": [
49,
53
]
} | {
"id": "C0015688",
"name": "ffa",
"pos": [
57,
60
]
} |
a specific antibody against proinsulin has been obtained by adsorbing the original anti-proinsulin guinea pig serum with a solid immunosorbent of sephadex-insulin . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
28,
38
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
155,
162
]
} |
the presence of proinsulin in calf serum has been demonstrated by ( a ) gel filtration of an acid alcohol extract of the serum followed by immunoassays of the fractions using anti-insulin or the specific anti-proinsulin serum , and ( b ) direct assay of calf serum with the specific anti-proinsulin serum . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
19,
26
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
288,
298
]
} |
hemin and hematin have been incorporated into single crystals of the condensed-ring planar hydrocarbon perylene , the approximate molecular ratio of heme to aromatic being 10 ( -3 ) . | NA | {
"id": "C0018988",
"name": "hemin",
"pos": [
0,
5
]
} | {
"id": "C0018966",
"name": "heme",
"pos": [
149,
153
]
} |
dna-like rna and ribosomal rna seem to be less stable in hybrids than in normal a. lixula and p. lividus embryos . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
9,
12
]
} | {
"id": "C0035701",
"name": "ribosomal rna",
"pos": [
17,
30
]
} |
( 1 ) among the dna-like rna ( drna ) species of rat brain , 35 per cent remain nuclear , whereas 65 per cent are found in the microsomes and may represent functional messenger rna . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
25,
28
]
} | {
"id": "C0887909",
"name": "functional",
"pos": [
156,
166
]
} |
with this technique , specific aminoacyl-trna-dna hybridization can be followed in the presence of other species of rna if the trna is acylated with radioactive amino acids . | NA | {
"id": "C0035714",
"name": "aminoacyl-trna",
"pos": [
31,
45
]
} | {
"id": "C0002520",
"name": "amino",
"pos": [
161,
166
]
} |
skin fibroblasts from patients fail to proliferate in media that do not contain supplementary adenine or folic acid , a participant in two stages of purine biosynthesis . | NA | {
"id": "C0001407",
"name": "adenine",
"pos": [
94,
101
]
} | {
"id": "C0034140",
"name": "purine",
"pos": [
149,
155
]
} |
rat pineal glands in organ culture can form c ( 14 ) -melatonin from c ( 14 ) -tryptophan as follows : tryptophan -- > 5-hydroxytryptophan -- > serotonin -- > melatonin . | NA | {
"id": "C0041249",
"name": "tryptophan",
"pos": [
79,
89
]
} | {
"id": "C0000578",
"name": "5-hydroxytryptophan",
"pos": [
119,
138
]
} |
the interaction between different metabolic pathways of catecholamines in the brain studied by means of 3h-dopa . | NA | {
"id": "C0007412",
"name": "catecholamines",
"pos": [
56,
70
]
} | {
"id": "C0013023",
"name": "dopa",
"pos": [
107,
111
]
} |
studies on the use of anion exchangers in the chloride cycle for sorption of pyrogenic substances . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
22,
27
]
} | {
"id": "C0008203",
"name": "chloride",
"pos": [
46,
54
]
} |
the uptake of exogenous cholesterol into the intestinal wall was similarly related to the chain length of the carrier triglyceride , with the exception of triacetin , which gave a much higher intestinal uptake than lymphatic transport . | NA | {
"id": "C0041004",
"name": "triglyceride",
"pos": [
118,
130
]
} | {
"id": "C0040853",
"name": "triacetin",
"pos": [
155,
164
]
} |
the purified product ( almost identical with the phytoglycolipid isolated from flax seed ) was a ceramide attached through phosphate diester linkage to an oligosaccharide , which consisted of the usual trisaccharide unit ( inositol , hexuronic acid , hexosamine ) to which were attached mannose , galactose , and arabino... | NA | {
"id": "C0028959",
"name": "oligosaccharide",
"pos": [
155,
170
]
} | {
"id": "C0041102",
"name": "trisaccharide",
"pos": [
202,
215
]
} |
in the cerebroside , the fatty acid composition was similar to that in the ceramide and phytoglycolipid , but the long-chain bases consisted of dehydrophytosphingosine and phytosphingosine ( 7:1 ) with a substantial amount of unidentified long-chain base . | NA | {
"id": "C0007805",
"name": "cerebroside",
"pos": [
7,
18
]
} | {
"id": "C0007745",
"name": "ceramide",
"pos": [
75,
83
]
} |
it was concluded that the lipoproteins in the golgi apparatus are the precursors of plasma very low density lipoproteins . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
26,
38
]
} | {
"id": "C0023825",
"name": "very low",
"pos": [
91,
99
]
} |
fatty acid analysis showed that stearic acid was the major component , with minor amounts of palmitic and arachidic acids . | NA | {
"id": "C0015684",
"name": "fatty acid",
"pos": [
0,
10
]
} | {
"id": "C0013724",
"name": "arachidic acids",
"pos": [
106,
121
]
} |
these derivatives of glycerol ethers can be quantitated by uv absorbance , analyzed by gas-liquid chromatography , or quantitatively converted to allyl alkyl ethers for gas-chromatographic analysis . | NA | {
"id": "C0017886",
"name": "glycerol ethers",
"pos": [
21,
36
]
} | {
"id": "C0014996",
"name": "ethers",
"pos": [
158,
164
]
} |
simultaneous separation and quantitative determination of tetracycline , anhydrotetracycline , 4-epitetracycline , and 4-epi-anhydrotetracycline in degraded tetracyclines by thin-layer chromatography . | NA | {
"id": "C0039644",
"name": "tetracycline",
"pos": [
58,
70
]
} | {
"id": "C0039651",
"name": "tetracyclines",
"pos": [
157,
170
]
} |
[ studies on bronchial asthma . 4. on occupational asthma considered to be caused by lycopodium clavatum ] . | NA | {
"id": "C0004096",
"name": "bronchial asthma",
"pos": [
13,
29
]
} | {
"id": "C0264423",
"name": "occupational asthma",
"pos": [
38,
57
]
} |
within the ipsilateral olfactory tubercle , there is also a significant decrease in the activity of the enzyme phenylethanolamine-n-methyl transferase , which catalyzes the conversion of norepinephrine to epinephrine . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
187,
201
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
205,
216
]
} |
in contrast , in the pseudorotation mechanism one histidine residue performs all the catalytic functions , while the other serves only to bind the phosphate anion ; | NA | {
"id": "C0031603",
"name": "phosphate",
"pos": [
147,
156
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
157,
162
]
} |
antibody specificity was demonstrated by the absence of serological cross reactions or enzyme inhibition with bovine erythrocyte acetylcholinesterase or horse serum cholinesterase . | NA | {
"id": "C0001044",
"name": "acetylcholinesterase",
"pos": [
129,
149
]
} | {
"id": "C0008429",
"name": "cholinesterase",
"pos": [
165,
179
]
} |
polypeptide chain initiation in e. coli : isolation of homogeneous initiation factor e2 and its relation to ribosomal proteins . | NA | {
"id": "C0030943",
"name": "initiation",
"pos": [
18,
28
]
} | {
"id": "C0035552",
"name": "ribosomal proteins",
"pos": [
108,
126
]
} |
an enzyme isolated from aerobacter aerogenes acts both as phosphomonoesterase and phosphotransferase with glucose , glucosides , glucosamine , and n-acetyl glucosamine as acceptors . | NA | {
"id": "C0017718",
"name": "glucosamine",
"pos": [
129,
140
]
} | {
"id": "C0001056",
"name": "n-acetyl",
"pos": [
147,
155
]
} |
resistance to ampicillin in escherichia coli is due generally to the presence of a beta-lactamase ( penicillinase ) . | NA | {
"id": "C0597979",
"name": "beta-lactamase",
"pos": [
83,
97
]
} | {
"id": "C0030841",
"name": "penicillinase",
"pos": [
100,
113
]
} |
culture filtrates of mucor pusillus nrrl 2543 contained hydrolytic enzymes that attacked native cellulose , acid-swollen cellulose , carboxymethylcellulose , and cellobiose . | NA | {
"id": "C0007648",
"name": "cellulose",
"pos": [
96,
105
]
} | {
"id": "C0007630",
"name": "cellobiose",
"pos": [
162,
172
]
} |
acid-swollen cellulose , when treated with cellulase free of beta-glucosidase activity , gave rise to glucose , cellobiose , and at least two higher molecular weight components which were also hydrolyzed in turn to cellobiose and glucose . | NA | {
"id": "C0007648",
"name": "cellulose",
"pos": [
13,
22
]
} | {
"id": "C0007630",
"name": "cellobiose",
"pos": [
215,
225
]
} |
determination of protein binding values of aminopyrine , 4-aminoantipyrine and n-acetyl-4-aminoantipyrine in bovine plasma and milk . | NA | {
"id": "C0002586",
"name": "aminopyrine",
"pos": [
43,
54
]
} | {
"id": "C0002696",
"name": "aminoantipyrine",
"pos": [
90,
105
]
} |
although divalent cation absorption from the ca-mg-mn system was essentially nil , k absorption was greatly stimulated in the presence of these cations . | NA | {
"id": "C0007448",
"name": "divalent cation",
"pos": [
9,
24
]
} | {
"id": "C0007447",
"name": "cations",
"pos": [
144,
151
]
} |
these mutual effects and others reported in the literature are explained by the hypothesis that selectivity in ion absorption results from cation-induced conformational changes in the structure of the carrier molecule . | NA | {
"id": "C0022023",
"name": "ion",
"pos": [
111,
114
]
} | {
"id": "C0007447",
"name": "cation",
"pos": [
139,
145
]
} |
many single amino acids are inhibitory , and when added ( at 2 mm or less ) to cultures , growing in the presence of nitrate , cause a decrease in growth rate or even death of the plants ( e.g . with alanine , valine , methionine or leucine ) . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
12,
23
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
200,
207
]
} |
ammonia represses the nitrate induced synthesis of both nr and nir.nadh dependent gdh activity is low when grown on amino acids and high when grown on nitrate or ammonia , but the activities of nadph dependent gdh and alanine dehydro-genase ( aidh ) are much less affected by nitrogen source . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
116,
127
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
218,
225
]
} |
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