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BioRel

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susceptibility of cultured mammalian cells to infection with a herpesvirus from marek 's disease and t-virus from reticuloendotheliosis of chickens .
NA
{ "id": "C0019372", "name": "infection", "pos": [ 46, 55 ] }
{ "id": "C0024793", "name": "marek 's disease", "pos": [ 80, 96 ] }
attempts to produce in vitro the reaction of immunologically competent cells of c57bl-6 origin to balb-c embryo fibroblasts .
NA
{ "id": "C0007634", "name": "the", "pos": [ 29, 32 ] }
{ "id": "C0016030", "name": "fibroblasts", "pos": [ 112, 123 ] }
[ relationships between polyamines and nucleic acids . i. influence of food deprivation , phenobarbital and perfluorobutyric acid on the nucleic acid , spermine and spermidine content of mouse liver ] .
NA
{ "id": "C0037874", "name": "spermine", "pos": [ 152, 160 ] }
{ "id": "C0037871", "name": "content", "pos": [ 176, 183 ] }
in an attempt to ascertain whether specific base-pairing could have a regulating function in an enzyme system in which nucleotides serve as the substrate , we studied the effects of the addition of the various homopolymers of the ribonucleotide series on the action of adenylate kinase on adp or cdp , and found that the...
NA
{ "id": "C0028630", "name": "nucleotides", "pos": [ 119, 130 ] }
{ "id": "C0035548", "name": "ribonucleotide", "pos": [ 230, 244 ] }
[ electrotherapy of arrhythmia . hemodynamic studies and electric treatment of atrial fibrillation , atrial flutter and disturbances of atrioventricular conduction ] .
NA
{ "id": "C0003811", "name": "arrhythmia", "pos": [ 20, 30 ] }
{ "id": "C0004238", "name": "atrial fibrillation", "pos": [ 79, 98 ] }
[ electrotherapy of arrhythmia . hemodynamic studies and electric treatment of atrial fibrillation , atrial flutter and disturbances of atrioventricular conduction ] .
NA
{ "id": "C0003811", "name": "arrhythmia", "pos": [ 20, 30 ] }
{ "id": "C0004239", "name": "atrial flutter", "pos": [ 101, 115 ] }
[ on the alkyl-substituted steroids . v. testosterone excretion in man after oral administration of 1alpha-methyl-5alpha-androstane-17beta ol-3-one ( mesterolone ) and 17-alpha-methyl-androst-4-en-17beta-ol-3-one ( 17 alpha-methyltestosterone ) ] .
NA
{ "id": "C0038317", "name": "steroids", "pos": [ 27, 35 ] }
{ "id": "C0002854", "name": "androstane", "pos": [ 121, 131 ] }
administration of the catecholamine precursor , l-3,4-dihydroxyphenylalanine to the reserpine-and alpha-methyltyrosine-treated rats elevated the tyrosine transaminase activity to normal .
NA
{ "id": "C0007412", "name": "catecholamine", "pos": [ 22, 35 ] }
{ "id": "C0013023", "name": "dihydroxyphenylalanine", "pos": [ 54, 76 ] }
biosynthesis of insulin in bovine fetal pancreatic slices : the incorporation of tritiated leucine into a single-chain proinsulin , a double-chain intermediate , and insulin in subcellular fractions .
NA
{ "id": "C0033362", "name": "proinsulin", "pos": [ 119, 129 ] }
{ "id": "C0021641", "name": "insulin", "pos": [ 166, 173 ] }
double-chain proinsulin and insulin were found as major components in the mitochondrial-granule fraction of bovine fetal pancreas .
NA
{ "id": "C0033362", "name": "proinsulin", "pos": [ 13, 23 ] }
{ "id": "C0021641", "name": "insulin", "pos": [ 28, 35 ] }
however , they do not bind to rrna , srna , tmv-rna , poly cg , or native poly dg : dc .
NA
{ "id": "C0035701", "name": "rrna", "pos": [ 30, 34 ] }
{ "id": "C0035668", "name": "rna", "pos": [ 48, 51 ] }
fractionation of this rna by polyacrylamide gel electrophoresis revealed the synthesis of two discrete peaks of labeled rna migrating in the region between 18s ribosomal and 4s transfer rna .
NA
{ "id": "C0035668", "name": "rna", "pos": [ 22, 25 ] }
{ "id": "C0035711", "name": "transfer", "pos": [ 177, 185 ] }
a procedure for the isolation and purification of the heparin-protein complex from ox liver capsule , based on the solubility properties of mucopolysaccharide-cetylpyridinium complexes , is described .
NA
{ "id": "C0019134", "name": "heparin", "pos": [ 54, 61 ] }
{ "id": "C0017973", "name": "mucopolysaccharide", "pos": [ 140, 158 ] }
the interactions of retinol and retinoic acid with two electron acceptors , 7,7,8,8-tetracyanoquinodimethane ( tcnq ) and tetrachloro-1,4-benzoquinone ( chloranil ) , were studied in an investigation on the ability of vitamin a to behave as a donor of electrons .
NA
{ "id": "C0040845", "name": "retinoic acid", "pos": [ 32, 45 ] }
{ "id": "C0042839", "name": "vitamin a", "pos": [ 218, 227 ] }
consumption of oh ( - ) ions is also a feature of the reactions between retinol and chloranil , but the spectrum of the radical anion of chloranil is observed only when retinol and chloranil are suspended in aqueous salt solutions .
NA
{ "id": "C0022023", "name": "ions", "pos": [ 24, 28 ] }
{ "id": "C0003075", "name": "anion", "pos": [ 128, 133 ] }
the reactions of retinol and retinoic acid with iodine were investigated since knowledge of the chemical reactions of vitamin a with acceptors of electrons may shed light on its biochemical mode of action .
NA
{ "id": "C0040845", "name": "retinoic acid", "pos": [ 29, 42 ] }
{ "id": "C0042839", "name": "vitamin a", "pos": [ 118, 127 ] }
it is suggested that the chemical properties of retinol and retinoic acid that underlie their biochemical behaviour might be apparent only when the molecules are at a lipid-water interface , and that vitamin a might be expected to react with a number of different electron acceptors in vivo .
NA
{ "id": "C0040845", "name": "retinoic acid", "pos": [ 60, 73 ] }
{ "id": "C0042839", "name": "vitamin a", "pos": [ 200, 209 ] }
an example is given of 5alpha-androstan-3-one and 5alpha-androstane-3,16-dione as substrates competing for a hydroxy steroid-nad oxidoreductase ( ec 1.1.1.53 ) .
NA
{ "id": "C0002854", "name": "androstane", "pos": [ 57, 67 ] }
{ "id": "C0038317", "name": "steroid", "pos": [ 117, 124 ] }
the incorporation of methyl-labeled choline into phosphorylcholine and phosphatidylcholine of cellular membranes by novikoff rat hepatoma cells ( line n1s1-67 ) during growth in suspension culture was investigated .
NA
{ "id": "C0008405", "name": "choline", "pos": [ 36, 43 ] }
{ "id": "C0031716", "name": "phosphorylcholine", "pos": [ 49, 66 ] }
the decrease in phosphorylcholine synthesis during the growth cycle was not due to depletion of choline in the medium or a decrease in its concentration , but was correlated with a decrease in choline kinase activity of the cells as measured in cell-free extracts .
NA
{ "id": "C0031716", "name": "phosphorylcholine", "pos": [ 16, 33 ] }
{ "id": "C0008405", "name": "choline", "pos": [ 193, 200 ] }
[ measurement of the coronary blood supply with the argon inert gas method . animal experiments and studies on patients with low and high blood supply ] .
NA
{ "id": "C0003781", "name": "argon", "pos": [ 52, 57 ] }
{ "id": "C0017112", "name": "inert gas", "pos": [ 58, 67 ] }
arginine or homoarginine , and to a smaller extent some other amino acids or fumarate , protected the enzyme from cold-inactivation .
NA
{ "id": "C0003765", "name": "arginine", "pos": [ 0, 8 ] }
{ "id": "C0019877", "name": "homoarginine", "pos": [ 12, 24 ] }
the single dose was virtually ineffective in children under 5 years , but provided significant protection in older children .
NA
{ "id": "C0008059", "name": "children", "pos": [ 45, 53 ] }
{ "id": "C1455726", "name": "older children", "pos": [ 109, 123 ] }
[ flotation analysis studies of lipoproteins in correlation with the lipid pattern in essential hyperlipemia and diabetic metabolism status ] .
NA
{ "id": "C0023820", "name": "lipoproteins", "pos": [ 32, 44 ] }
{ "id": "C0023779", "name": "lipid", "pos": [ 69, 74 ] }
[ changes in the content of thiol groups in proteins of the globulin fraction of cell nuclei from the liver of x-irradiated rats ] .
NA
{ "id": "C0033684", "name": "proteins", "pos": [ 44, 52 ] }
{ "id": "C0017649", "name": "globulin", "pos": [ 60, 68 ] }
[ the results of the stay of children with chronic pneumonia and bronchial asthma in climatic conditions at the union pioneer camp `` '' artek '' '' ] .
NA
{ "id": "C0006261", "name": "bronchial", "pos": [ 65, 74 ] }
{ "id": "C0004096", "name": "asthma", "pos": [ 75, 81 ] }
we propose that these ambivalent effects of fluoroleucine on repression and rna and protein synthesis in the two strains are due to differences in the ability of the analogue to attach to the various species of leucine transfer rna .
NA
{ "id": "C0035668", "name": "rna", "pos": [ 76, 79 ] }
{ "id": "C0035711", "name": "transfer rna", "pos": [ 219, 231 ] }
three kinds of messenger ribonucleic acid ( rna ) were employed : endogenous cellular rna , extracted cellular rna , and phage r17 rna .
NA
{ "id": "C0035696", "name": "messenger", "pos": [ 15, 24 ] }
{ "id": "C0035668", "name": "rna", "pos": [ 131, 134 ] }
the sedimentation coefficients for these enzymes are very similar in the six species and are comparable to those previously observed for the multienzyme complexes ( arom aggregates ) of neurospora crassa and saccharomyces cerevisiae .
NA
{ "id": "C0014442", "name": "enzymes", "pos": [ 41, 48 ] }
{ "id": "C0026741", "name": "multienzyme complexes", "pos": [ 141, 162 ] }
renaturation studies of halophile dna exclude the possibility that the satellite dna represents multiple copies of a small episomal element .
NA
{ "id": "C0012854", "name": "dna", "pos": [ 34, 37 ] }
{ "id": "C0012934", "name": "satellite dna", "pos": [ 71, 84 ] }
at high levels of delta-aminolevulinic acid , there was also a significant accumulation of porphyrins with the solubility and chromatographic properties of coproporphyrin and uroporphyrin .
NA
{ "id": "C0032712", "name": "porphyrins", "pos": [ 91, 101 ] }
{ "id": "C0009988", "name": "coproporphyrin", "pos": [ 156, 170 ] }
at high levels of delta-aminolevulinic acid , there was also a significant accumulation of porphyrins with the solubility and chromatographic properties of coproporphyrin and uroporphyrin .
NA
{ "id": "C0032712", "name": "porphyrins", "pos": [ 91, 101 ] }
{ "id": "C0042093", "name": "uroporphyrin", "pos": [ 175, 187 ] }
the d-glycero enantiomer , r-1- ( 2,3-dihydroxypropyl ) thymine and the corresponding 1-substituted uracil derivative were prepared from 3-o-p-toluenesulfonyl-1 , 2-o-isopropylidene-d-glycerine and sodium salt of 4-methoxy-5-methylpyrimidin-2-one or 4-methoxypyrimidin-2-one followed by treatment with hydrogen chloride ...
NA
{ "id": "C0040087", "name": "thymine", "pos": [ 56, 63 ] }
{ "id": "C0041917", "name": "uracil", "pos": [ 100, 106 ] }
the composition of the 3'terminal , 5'terminal and 5'penultimate nucleotides of the oligonucleotides released by spleen acid dnase and snail acid dnase from five ; repetitive ' dnas ( guinea pig , mouse and crab satellite dnas , yeast mitochondrial dna and poly ( dat : dat ) ) and four ; eukaryotic ' dnas ( calf thymus...
NA
{ "id": "C0012934", "name": "satellite dnas", "pos": [ 212, 226 ] }
{ "id": "C0012854", "name": "dnas", "pos": [ 482, 486 ] }
the composition of the 3'terminal , 5'terminal and 5'penultimate nucleotides of the oligonucleotides released by spleen acid dnase and snail acid dnase from five ; repetitive ' dnas ( guinea pig , mouse and crab satellite dnas , yeast mitochondrial dna and poly ( dat : dat ) ) and four ; eukaryotic ' dnas ( calf thymus...
NA
{ "id": "C0012854", "name": "dnas", "pos": [ 125, 129 ] }
{ "id": "C0012924", "name": "bacterial", "pos": [ 472, 481 ] }
aminoacyl ( phe , gly ) derivatives of nucleoside aliphatic analogues bearing a hydroxyalkyl chain have been prepared by the condensation of the alcohols with n-benzyloxycarbonyl-amino acid in the presence of dcc followed by hydrogenolysis in methanol .
NA
{ "id": "C0001975", "name": "alcohols", "pos": [ 145, 153 ] }
{ "id": "C0001963", "name": "methanol", "pos": [ 243, 251 ] }
relative to magnesium-equilibrated rna , barium ion and putrescine induced alterations in the electrophoretic behavior of ribosomal rna while calcium ion produced no change .
NA
{ "id": "C0035668", "name": "rna", "pos": [ 35, 38 ] }
{ "id": "C0035701", "name": "ribosomal rna", "pos": [ 122, 135 ] }
this satellite virus dna does not appear to differ in its physical , chemical and biological properties from dna isolated directly from virions or from cells co-infected with adenovirus .
NA
{ "id": "C0012934", "name": "satellite", "pos": [ 5, 14 ] }
{ "id": "C0012854", "name": "dna", "pos": [ 109, 112 ] }
observed frequencies of restriction enzyme cleavage in viral dnas are compared to those expected from the cleavage site sequence and the known size and nearest neighbour frequencies of the dnas .
NA
{ "id": "C0012939", "name": "viral dnas", "pos": [ 55, 65 ] }
{ "id": "C0012854", "name": "dnas", "pos": [ 189, 193 ] }
bacteriophage pbs2 replication is unaffected by rifampicin and other rifamycin derivatives , which are potent inhibitors of bacillus subtilis rna synthesis .
NA
{ "id": "C0035608", "name": "rifampicin", "pos": [ 48, 58 ] }
{ "id": "C0035609", "name": "rifamycin", "pos": [ 69, 78 ] }
some general methods of covalent coupling of nucleotides , especially derivatized nucleotides , polynucleotides and cofactors to insoluble polymers are described in this paper .
NA
{ "id": "C0028630", "name": "nucleotides", "pos": [ 45, 56 ] }
{ "id": "C0032550", "name": "polynucleotides", "pos": [ 96, 111 ] }
metrizamide , an inert , non-ionic organic compound , dissolves in water to give a dense solution in which dna bands isopycnically at a density corresponding to that of fully hydrated dna .
NA
{ "id": "C0000702", "name": "a", "pos": [ 6, 7 ] }
{ "id": "C0012854", "name": "dna", "pos": [ 184, 187 ] }
and ( ii ) , the hydration of nadna varies with anion in the order sulphate < fluoride < chloride < bromide < iodide .
NA
{ "id": "C0003075", "name": "anion", "pos": [ 48, 53 ] }
{ "id": "C0038720", "name": "sulphate", "pos": [ 67, 75 ] }
and ( ii ) , the hydration of nadna varies with anion in the order sulphate < fluoride < chloride < bromide < iodide .
NA
{ "id": "C0003075", "name": "anion", "pos": [ 48, 53 ] }
{ "id": "C0016327", "name": "fluoride", "pos": [ 78, 86 ] }
and ( ii ) , the hydration of nadna varies with anion in the order sulphate < fluoride < chloride < bromide < iodide .
NA
{ "id": "C0003075", "name": "anion", "pos": [ 48, 53 ] }
{ "id": "C0008203", "name": "chloride", "pos": [ 89, 97 ] }
and ( ii ) , the hydration of nadna varies with anion in the order sulphate < fluoride < chloride < bromide < iodide .
NA
{ "id": "C0003075", "name": "anion", "pos": [ 48, 53 ] }
{ "id": "C0006222", "name": "bromide", "pos": [ 100, 107 ] }
and ( ii ) , the hydration of nadna varies with anion in the order sulphate < fluoride < chloride < bromide < iodide .
NA
{ "id": "C0003075", "name": "anion", "pos": [ 48, 53 ] }
{ "id": "C0021966", "name": "iodide", "pos": [ 110, 116 ] }
it is suggested that isopycnic centrifugation in metrizamide is a simple method for determining the effects of salts ( and other small molecules ) on the hydration of nucleic acids under conditions of high ratios of salt to dna ( > 5 x 10 ( 3 ) moles/mole ) while high ( 0.999 ) water activity is maintained .
NA
{ "id": "C0028606", "name": "nucleic acids", "pos": [ 167, 180 ] }
{ "id": "C0012854", "name": "dna", "pos": [ 224, 227 ] }
it is postulated that the amino acid and its nature influence the structure that the aminoacyl-trna assumes .
NA
{ "id": "C0002520", "name": "amino acid", "pos": [ 26, 36 ] }
{ "id": "C0035714", "name": "aminoacyl-trna", "pos": [ 85, 99 ] }
it is thus concluded that the absence of premelting is a property of native nucleoprotein where interactions between the different proteins complexed with dna can occur and especially between the non-histone proteins and the two slightly lysine-rich histone fractions .
NA
{ "id": "C0028612", "name": "nucleoprotein", "pos": [ 76, 89 ] }
{ "id": "C0033684", "name": "proteins", "pos": [ 208, 216 ] }
indeed by the use of u ( 2 ) -rnase with dg-rna , or pancreatic rnase with dc-rna or du-rna , base specific cleavage can be obtained at any of the four residues .
NA
{ "id": "C0014241", "name": "rnase", "pos": [ 30, 35 ] }
{ "id": "C0035541", "name": "pancreatic rnase", "pos": [ 53, 69 ] }
hydrogen-tritium exchange studies coupled with other considerations show that this reaction is not due to a difference in conformational motility between form i and form ii molecules , but is due to unpaired or weakly hydrogen bonded , localized region ( s ) of the form i allomorph of circular dna .
NA
{ "id": "C0041119", "name": "tritium", "pos": [ 9, 16 ] }
{ "id": "C0020275", "name": "hydrogen", "pos": [ 218, 226 ] }
sedimentation of dna from human fibroblasts irradiated with ultraviolet light : possible detection of excision breaks in normal and repair-deficient xeroderma pigmentosum cells .
NA
{ "id": "C0016030", "name": "fibroblasts", "pos": [ 32, 43 ] }
{ "id": "C0007634", "name": "cells", "pos": [ 171, 176 ] }
the amino acid composition of the normal gbm revealed the presence of significant amounts of hydroxyproline , hydroxylysine , glycine , and carbohydrate suggesting the presence of a collagen-like protein .
NA
{ "id": "C0002520", "name": "amino acid", "pos": [ 4, 14 ] }
{ "id": "C0017890", "name": "glycine", "pos": [ 126, 133 ] }
dit present in the second antiserum shifted the double antibody assay standard curve and altered estimates of assay specificity and assay sensitivity .
NA
{ "id": "C0020960", "name": "antiserum", "pos": [ 26, 35 ] }
{ "id": "C0003241", "name": "antibody", "pos": [ 55, 63 ] }
to test this hypothesis , we have administered to dogs ingesting a low nacl diet a daily dose of 7 meq/kg of h+ with anions ( chloride , sulfate , or nitrate ) whose differing degrees of reabsorbability influence the speed and completeness with which each is delivered to the distal nephron with its accompanying na+ .
NA
{ "id": "C0003075", "name": "anions", "pos": [ 117, 123 ] }
{ "id": "C0008203", "name": "chloride", "pos": [ 126, 134 ] }
to test this hypothesis , we have administered to dogs ingesting a low nacl diet a daily dose of 7 meq/kg of h+ with anions ( chloride , sulfate , or nitrate ) whose differing degrees of reabsorbability influence the speed and completeness with which each is delivered to the distal nephron with its accompanying na+ .
NA
{ "id": "C0003075", "name": "anions", "pos": [ 117, 123 ] }
{ "id": "C0038720", "name": "sulfate", "pos": [ 137, 144 ] }
to test this hypothesis , we have administered to dogs ingesting a low nacl diet a daily dose of 7 meq/kg of h+ with anions ( chloride , sulfate , or nitrate ) whose differing degrees of reabsorbability influence the speed and completeness with which each is delivered to the distal nephron with its accompanying na+ .
NA
{ "id": "C0003075", "name": "anions", "pos": [ 117, 123 ] }
{ "id": "C0028125", "name": "nitrate", "pos": [ 150, 157 ] }
jejunal biopsy specimens from patients with gluten-sensitive enteropathy ( gse ) ( obtained during gluten challenge ) as well as from normal individuals and patients with other gastrointestinal abnormalities were cultured in vitro for 48 h in the presence or absence of a peptic-tryptic digest ( p-t digest ) of gliadin ...
NA
{ "id": "C2362561", "name": "gluten", "pos": [ 44, 50 ] }
{ "id": "C0017622", "name": "gliadin", "pos": [ 312, 319 ] }
inasmuch as this effect of gliadin is not seen in cultures of specimens taken from patients in remission , it appears that gliadin is not directly toxic to gse jejunal mucosa per se , but rather toxicity requires the participation of an endogenous effector mechanism which must first be stimulated in vivo .
NA
{ "id": "C0017622", "name": "gliadin", "pos": [ 27, 34 ] }
{ "id": "C2362561", "name": "gse", "pos": [ 156, 159 ] }
the stimulation of either pathway required a chemotactically active stimulus since neither c5 nor prekallikrein or inactivated kallikrein could enhance metabolic activity .
NA
{ "id": "C0033024", "name": "prekallikrein", "pos": [ 98, 111 ] }
{ "id": "C0022478", "name": "kallikrein", "pos": [ 127, 137 ] }
addition of intact activated hageman factor corrected the coagulation , fibrinolytic , and chemotactic defects and addition of hageman factor fragments corrected the fibrinolytic defect and partially corrected the chemotactic defect ;
NA
{ "id": "C0015527", "name": "activated hageman factor", "pos": [ 19, 43 ] }
{ "id": "C0015525", "name": "hageman factor", "pos": [ 127, 141 ] }
separated single strands of 32p-labelled dna from escherichia coli were to a limited extent able to anneal with dna of micrococcus lysodeikticus immobilized on nitrocellulose membrane filters .
NA
{ "id": "C0012935", "name": "single strands", "pos": [ 10, 24 ] }
{ "id": "C0012854", "name": "dna", "pos": [ 112, 115 ] }
rna isolated from the supernatant fraction , sedimenting at 4 s and co-electrophoresing with transfer rna on polyacrylamide gels , contains several similar bases , one of which is identified as 3-gamma- ( alpha-amino-alpha-carboxypropyl ) uridine .
NA
{ "id": "C0035668", "name": "rna", "pos": [ 0, 3 ] }
{ "id": "C0035711", "name": "transfer rna", "pos": [ 93, 105 ] }
the method used is based on the fact that the known effective pharmacological and chemical radioprotectives ( aminoethylthiouronium bromide hbr ( aet ) , cystamine , sodium fluoroacetate ( fac ) , 5-hydroxytryptamine ( 5-ht ) , 5-methoxytryptamine ( 5-mt ) and others ) interfere directly or indirectly with enzymatic st...
NA
{ "id": "C0036751", "name": "5-ht", "pos": [ 219, 223 ] }
{ "id": "C0000589", "name": "5-methoxytryptamine", "pos": [ 228, 247 ] }
synthesis and enzymatic evaluation of pyridostigmine analogs used to probe the active sites of acetylcholinesterase and butyrylcholinesterase .
NA
{ "id": "C0001044", "name": "acetylcholinesterase", "pos": [ 95, 115 ] }
{ "id": "C0008429", "name": "butyrylcholinesterase", "pos": [ 120, 141 ] }
two prostaglandins ( e ( 1 ) and e ( 2 ) ) were effective in both systems , but prostaglandin f ( 2alpha ) was not .
NA
{ "id": "C0033554", "name": "prostaglandins", "pos": [ 4, 18 ] }
{ "id": "C0033561", "name": "prostaglandin f", "pos": [ 80, 95 ] }
dodecanoic and decanoic acids were as effective as c ( 18 ) fatty acids at 5 mm but octanoic and hexanoic acids were ineffective .
NA
{ "id": "C0011090", "name": "decanoic acids", "pos": [ 15, 29 ] }
{ "id": "C0015684", "name": "fatty acids", "pos": [ 60, 71 ] }
in a cell-free system prepared from guinea pig gastric mucosa , histamine and nalpha-methyl-histamine produced dose-dependent stimulation of cyclic amp formation and 1,4-methylhistamine had a minimal stimulatory effect .
NA
{ "id": "C0019588", "name": "histamine", "pos": [ 64, 73 ] }
{ "id": "C0025779", "name": "methyl-histamine", "pos": [ 85, 101 ] }
n-methyl-n'- ( 2- [ 5-methylimidazole-4-yl-methylthio ] -ethyl ) -thiourea ( metiamide ) , a new h2 receptor inhibitor , selectively blocked the stimulation of adenylate cyclase by histamine and its active methyl derivative but had no substantial effect on the basal adenylate cyclase activity or adenylate cyclase stimu...
NA
{ "id": "C0039958", "name": "thiourea", "pos": [ 66, 74 ] }
{ "id": "C0025845", "name": "metiamide", "pos": [ 77, 86 ] }
considerable controversy exists over the purported role of obesity in causing hyperglycemia , hyperlipemia , hyperinsulinemia , and insulin resistance ;
NA
{ "id": "C0020459", "name": "hyperinsulinemia", "pos": [ 109, 125 ] }
{ "id": "C0021655", "name": "insulin resistance", "pos": [ 132, 150 ] }
hypertriglyceridemia is one of the metabolic abnormalities proposed to accompany obesity , and in order to help explain the mechanisms leading to this abnormality we have proposed the following sequential hypothesis : insulin resistance -- > hyperinsulinemia -- > accelerated hepatic triglyceride ( tg ) production -- > ...
NA
{ "id": "C0021655", "name": "insulin resistance", "pos": [ 218, 236 ] }
{ "id": "C0020459", "name": "hyperinsulinemia", "pos": [ 242, 258 ] }
thus , weight reduction has lowered each of the antecedent variables ( insulin resistance , hyperinsulinemia , and vldl-tg production ) that according to the above hypothesis lead to hypertriglyceridemia , and we believe the overall scheme is greatly strengthened .
NA
{ "id": "C0021655", "name": "insulin resistance", "pos": [ 71, 89 ] }
{ "id": "C0020459", "name": "hyperinsulinemia", "pos": [ 92, 108 ] }
154 of 255 individual human renal biopsies studied by immunofluorescence contained varying combinations of immunoglobulins ( ig ) , complement ( c ) components c1q , c3 , c4 , c5 , c6 , c8 , c3 proactivator ( c3pa ) , and/or properdin .
NA
{ "id": "C0009498", "name": "complement", "pos": [ 132, 142 ] }
{ "id": "C0033453", "name": "c3 proactivator", "pos": [ 191, 206 ] }
the cellular uptake of n-acetyl-alpha-d-glucosaminidase , the deficient enzyme in sanfilippo b disease , and the intracellular fate and metabolic effect of this enzyme have been investigated in sanfilippo b and normal fibroblasts .
NA
{ "id": "C0007634", "name": "cellular", "pos": [ 4, 12 ] }
{ "id": "C0016030", "name": "fibroblasts", "pos": [ 218, 229 ] }
demonstration of the relationship between the adenine nucleotide carrier and the structural changes of mitochondria as induced by adenosine 5'-diphosphate .
NA
{ "id": "C0001413", "name": "adenine nucleotide", "pos": [ 46, 64 ] }
{ "id": "C0001459", "name": "adenosine 5", "pos": [ 130, 141 ] }
in one of the strains , balb/c , the receptors possess the same idiotype and fine degree of specificity for pc and two of its analogues , glycerophosphorylcholine and choline , that are characteristic of a pc-binding myeloma , hopc 8 .
NA
{ "id": "C0008405", "name": "choline", "pos": [ 155, 162 ] }
{ "id": "C0031716", "name": "pc", "pos": [ 229, 231 ] }
the ability of target cell bound antibodies to induce cytotoxicity in nonimmune spleen cells was restricted to the 7s antibody class .
NA
{ "id": "C0003241", "name": "antibodies", "pos": [ 33, 43 ] }
{ "id": "C0021017", "name": "antibody class", "pos": [ 118, 132 ] }
the in vitro effect of endotoxin ( lps ) on unfractionated mouse peritoneal cells and cells fractionated into glass adherent and nonadherent populations was studied .
NA
{ "id": "C0014264", "name": "endotoxin", "pos": [ 23, 32 ] }
{ "id": "C0023810", "name": "lps", "pos": [ 35, 38 ] }
the adenine nucleotides , adenosine diphosphate , adenosine triphosphate , ( atp ) , and the methylene-bridge analogues are inhibitors of rickettsial adsorption to and the hemolysis of sheep erythrocytes .
NA
{ "id": "C0001413", "name": "adenine nucleotides", "pos": [ 4, 23 ] }
{ "id": "C0001459", "name": "adenosine diphosphate", "pos": [ 26, 47 ] }
the adenine nucleotides , adenosine diphosphate , adenosine triphosphate , ( atp ) , and the methylene-bridge analogues are inhibitors of rickettsial adsorption to and the hemolysis of sheep erythrocytes .
NA
{ "id": "C0001413", "name": "adenine nucleotides", "pos": [ 4, 23 ] }
{ "id": "C0001480", "name": "adenosine triphosphate", "pos": [ 50, 72 ] }
the second product had a hexose-glycerol ratio of 2:1 and , in addition to glucose , contained lesser amounts of mannose and galactose .
NA
{ "id": "C0019494", "name": "hexose", "pos": [ 25, 31 ] }
{ "id": "C0024742", "name": "mannose", "pos": [ 113, 120 ] }
the second product had a hexose-glycerol ratio of 2:1 and , in addition to glucose , contained lesser amounts of mannose and galactose .
NA
{ "id": "C0019494", "name": "hexose", "pos": [ 25, 31 ] }
{ "id": "C0016945", "name": "galactose", "pos": [ 125, 134 ] }
the products have thus been identified as monoglycosyldiglyceride and a diglycosyldiglyceride containing glucose as the major hexose along with mannose and galactose .
NA
{ "id": "C0017725", "name": "glucose", "pos": [ 105, 112 ] }
{ "id": "C0019494", "name": "hexose", "pos": [ 126, 132 ] }
the products have thus been identified as monoglycosyldiglyceride and a diglycosyldiglyceride containing glucose as the major hexose along with mannose and galactose .
NA
{ "id": "C0019494", "name": "hexose", "pos": [ 126, 132 ] }
{ "id": "C0024742", "name": "mannose", "pos": [ 144, 151 ] }
the products have thus been identified as monoglycosyldiglyceride and a diglycosyldiglyceride containing glucose as the major hexose along with mannose and galactose .
NA
{ "id": "C0019494", "name": "hexose", "pos": [ 126, 132 ] }
{ "id": "C0016945", "name": "galactose", "pos": [ 156, 165 ] }
these results indicated that d-glucose was not utilized by cells of s. itersonii because this bacterium was impermeable to this hexose .
NA
{ "id": "C0017725", "name": "glucose", "pos": [ 31, 38 ] }
{ "id": "C0019494", "name": "hexose", "pos": [ 128, 134 ] }
in a mixture containing asparagine and either l-alanine or l-glutamic acid , amino acid utilization is diphasic , with asparagine being utilized first .
NA
{ "id": "C0001898", "name": "l-alanine", "pos": [ 46, 55 ] }
{ "id": "C0002520", "name": "amino acid", "pos": [ 77, 87 ] }
the action of cyclic amp is specific , inasmuch as adenosine triphosphate , 3'-amp , 5'-amp , adenosine , and dibutyryl cyclic amp are inactive .
NA
{ "id": "C0001455", "name": "cyclic amp", "pos": [ 14, 24 ] }
{ "id": "C0012054", "name": "dibutyryl cyclic amp", "pos": [ 110, 130 ] }
during the first 30 min of germination , spores synthesize ribosomal ribonucleic acid ( rna ) and heterogeneously sedimenting rna , i.e. , presumptive messenger rna .
NA
{ "id": "C0035701", "name": "ribosomal ribonucleic", "pos": [ 59, 80 ] }
{ "id": "C0035668", "name": "rna", "pos": [ 161, 164 ] }
during the first 30 min of germination , spores synthesize ribosomal ribonucleic acid ( rna ) and heterogeneously sedimenting rna , i.e. , presumptive messenger rna .
NA
{ "id": "C0035668", "name": "rna", "pos": [ 88, 91 ] }
{ "id": "C0035696", "name": "messenger rna", "pos": [ 151, 164 ] }
the origins of the carbon skeletons of all the acid-stable amino acids except isoleucine were found to be consistent with known biosynthetic pathways for these amino acids .
NA
{ "id": "C0815040", "name": "acid", "pos": [ 47, 51 ] }
{ "id": "C0002520", "name": "amino acids", "pos": [ 160, 171 ] }
analysis of the fractions for mrna specific for the lac and trp operons by rna-deoxyribonucleic acid hydridization showed somewhat larger amounts on membrane than on free polyribosomes , but enrichment for nascent alkaline phosphatase ( a secreted protein ) on membranes was consistently greater , suggesting that polyri...
NA
{ "id": "C0035696", "name": "mrna", "pos": [ 30, 34 ] }
{ "id": "C0035668", "name": "rna", "pos": [ 75, 78 ] }
in escherichia coli , the three branched-chain amino acid activating enzymes appear to be essential for multivalent repression of the isoleucine- and valine-forming enzymes .
NA
{ "id": "C0002521", "name": "branched-chain amino acid", "pos": [ 32, 57 ] }
{ "id": "C0022192", "name": "isoleucine", "pos": [ 134, 144 ] }
in escherichia coli , the three branched-chain amino acid activating enzymes appear to be essential for multivalent repression of the isoleucine- and valine-forming enzymes .
NA
{ "id": "C0002521", "name": "branched-chain amino acid", "pos": [ 32, 57 ] }
{ "id": "C0042285", "name": "valine", "pos": [ 150, 156 ] }
the molecule seems to be composed of lipid a and the hexoses , glucose and galactose .
NA
{ "id": "C0019494", "name": "hexoses", "pos": [ 53, 60 ] }
{ "id": "C0016945", "name": "galactose", "pos": [ 75, 84 ] }
the cellular mediated immunity of 51 young chronic marihuana smokers . as evaluated by the lyomphocyte response in vitro to allogeneic cells and to phytohemagglutinin , was significantly decreased and similar to that of patients in whom impairment of t ( thymus derived ) cell immunity is known to occur .
NA
{ "id": "C3485979", "name": "allogeneic cells", "pos": [ 124, 140 ] }
{ "id": "C0007634", "name": "cell", "pos": [ 272, 276 ] }
the kinetics of stimulation of 5s rna differ from those of the synthesis of 4s and of ribosomal rna .
NA
{ "id": "C0035668", "name": "rna", "pos": [ 34, 37 ] }
{ "id": "C0035701", "name": "ribosomal rna", "pos": [ 86, 99 ] }
since chloroplasts synthesize some of their membrane proteins , and a portion of chloroplast ribosomes is bound to chloroplast membranes through nascent protein chains , it is suggested that the membrane-bound ribosomes are synthesizing membrane protein .
NA
{ "id": "C0033684", "name": "protein", "pos": [ 53, 60 ] }
{ "id": "C0025252", "name": "membrane", "pos": [ 237, 245 ] }
narcolepsy is a disorder of sleep control characterized by a tetrad of symptoms : sleep attacks , cataplexy , sleep paralysis and hypnagogic hallucinations .
NA
{ "id": "C0027404", "name": "narcolepsy", "pos": [ 0, 10 ] }
{ "id": "C0007384", "name": "cataplexy", "pos": [ 98, 107 ] }