text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
serradella component i : ala32 , arg1 , ( asp + asn ) 10 , ( glu + gln ) 18 , gly8 , his3 , ile5 , leu5 , lys13 , phe8 , pro4 , ser14 , thr7 , try2 , tyr3 and val12 . | NA | {
"id": "C0061472",
"name": "glu",
"pos": [
61,
64
]
} | {
"id": "C0017797",
"name": "gln",
"pos": [
67,
70
]
} |
serradella component ii : ala37 , arg1 , ( asp + asn ) 11 , ( glu + gln ) 20 , gly9 , his3 , ile6 , leu17 , lys15 , phe9 , pro5 , ser16 , thr8 , try2 , tyr3 and val13 . | NA | {
"id": "C0061472",
"name": "glu",
"pos": [
62,
65
]
} | {
"id": "C0017797",
"name": "gln",
"pos": [
68,
71
]
} |
notable features of these are ( a ) the absence of cyst ( e ) ine , which suggests that each is a single polypeptide chain ( b ) the presence of a methionine residue in the lupin leghaemoglobins , and ( c ) the high contents of alanine , aspartic acid plus asparagine , glutamic acid plus glutamine , leucine , lysine , ... | NA | {
"id": "C0061472",
"name": "glutamic acid",
"pos": [
270,
283
]
} | {
"id": "C0017797",
"name": "glutamine",
"pos": [
289,
298
]
} |
the conversion of the trypsinogens to active enzymes is autocatalytic with the formation of active enzymes with higher isoelectric points than the zymogens . | NA | {
"id": "C0041243",
"name": "trypsinogens",
"pos": [
22,
34
]
} | {
"id": "C0014436",
"name": "zymogens",
"pos": [
147,
155
]
} |
although the amino acid compositions of the two trypsins were similar to those of other mammalian trypsins , a significant difference in content of acidic and basic amino acids , respectively , was found between the two dog trypsins . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
13,
23
]
} | {
"id": "C0301714",
"name": "basic",
"pos": [
159,
164
]
} |
analysis of the bound steroids revealed that , along with progesterone , small amounts of its metabolites ( 20alpha-hydroxy-4-pregnene-3-one , 5alpha-pregnane-3,20-dione , 5alpha-pregnane-20alpha-ol-3-one ) were also bound to the receptor proteins . | NA | {
"id": "C0038317",
"name": "steroids",
"pos": [
22,
30
]
} | {
"id": "C0033006",
"name": "pregnane",
"pos": [
179,
187
]
} |
among the steroids studied for ligand specificity , 5alpha-pregnane-3,20-dione showed the highest competition for progesterone binding sites . | NA | {
"id": "C0038317",
"name": "steroids",
"pos": [
10,
18
]
} | {
"id": "C0033006",
"name": "pregnane",
"pos": [
59,
67
]
} |
glycogen phosphorylase b modified by nabh4 and aliphatic aldehydes of varying chain length : ranging from acetaldehyde to n-heptanaldehyde were purified by heat-treatment . | NA | {
"id": "C0001992",
"name": "aldehydes",
"pos": [
57,
66
]
} | {
"id": "C0000966",
"name": "acetaldehyde",
"pos": [
106,
118
]
} |
secretory immunoglobulin a ( iga ) and free secretory component were purified from human milk using methods involving ( nh4 ) 2so4 precipitation , ion-exchange and gel-filtration chromatography . | NA | {
"id": "C0020838",
"name": "secretory immunoglobulin a",
"pos": [
0,
26
]
} | {
"id": "C0036538",
"name": "secretory component",
"pos": [
44,
63
]
} |
a measurement technique is discussed that allows for remote sensing of polluting gases that are emitted together with the water droplets in a steam plume . | NA | {
"id": "C0043047",
"name": "water",
"pos": [
122,
127
]
} | {
"id": "C0038225",
"name": "steam",
"pos": [
142,
147
]
} |
the proposed mechanism has been confirmed in terms of the chemisorption of deuterium and the release of heavy water . | NA | {
"id": "C0011744",
"name": "deuterium",
"pos": [
75,
84
]
} | {
"id": "C0011745",
"name": "heavy water",
"pos": [
104,
115
]
} |
the first extensive measurements by remote-sensing correlation spectrometry of the sulfur dioxide emitted by volcanic plumes indicate that on the order of 10 ( 3 ) metric tons of sulfur dioxide gas enter the atmosphere daily from central american volcanoes . | NA | {
"id": "C0038777",
"name": "sulfur dioxide",
"pos": [
83,
97
]
} | {
"id": "C0017110",
"name": "gas",
"pos": [
194,
197
]
} |
warm surface water , when evaporated , generates steam , to power a turbine , then fresh water when the steam is condensed by the cold water . | NA | {
"id": "C0038225",
"name": "steam",
"pos": [
49,
54
]
} | {
"id": "C0043047",
"name": "water",
"pos": [
135,
140
]
} |
although incorporation of ( 14 ) c-labelled amino acid into microsomal cytochrome b ( 5 ) is also rapidly inhibited , cycloheximide incompletely inhibits haem labelling of cytochrome b ( 5 ) and cytochrome a+a ( 3 ) , and inhibition occurs only after repeated antibiotic injections . | NA | {
"id": "C1256751",
"name": "haem",
"pos": [
154,
158
]
} | {
"id": "C0010798",
"name": "cytochrome",
"pos": [
195,
205
]
} |
aerobic incubation produces a similar pattern of amino acids except that amino acids such as proline , serine , asparagine , glutamic acid and glutamine , which can be metabolically utilized under aerobic conditions , are present to a smaller extent . | NA | {
"id": "C0061472",
"name": "glutamic acid",
"pos": [
125,
138
]
} | {
"id": "C0017797",
"name": "glutamine",
"pos": [
143,
152
]
} |
this discovery of relatively high proportions of chondroitin 4-sulphate in these mastocytoma-derived cells is noteworthy , since mast cells have generally been considered to produce heparin as their major glycosaminoglycan . | NA | {
"id": "C0019134",
"name": "heparin",
"pos": [
182,
189
]
} | {
"id": "C0017973",
"name": "glycosaminoglycan",
"pos": [
205,
222
]
} |
the ( 14 ) c-labelled glycosaminoglycan formed in the presence of udp-n-acetylgalactosamine was degradable by testicular hyaluronidase , indicating that it was chondroitin-like . | NA | {
"id": "C0017973",
"name": "glycosaminoglycan",
"pos": [
22,
39
]
} | {
"id": "C0008454",
"name": "chondroitin",
"pos": [
160,
171
]
} |
insulin-secretion studies with islets from normal and pregnant rats showed that theophylline or 3-isobutyl-1-methylxanthine , which raise intracellular cyclic amp concentrations , caused a significantly greater insulin secretion in pregnancy . | NA | {
"id": "C0039771",
"name": "theophylline",
"pos": [
80,
92
]
} | {
"id": "C0000096",
"name": "3-isobutyl-1-methylxanthine",
"pos": [
96,
123
]
} |
the appearance of exogenous cholesterol in free cholesterol and ester cholesterol of plasma chylomicra , very-low-density ( vld ) , low-density ( ld ) and high-density ( hd ) lipoproteins was studied in unanaesthetized rabbits after ingestion of a meal containing 5 % fat and 0.08 % [ ( 3 ) h ] cholesterol . | NA | {
"id": "C0008387",
"name": "ester",
"pos": [
32,
37
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
295,
306
]
} |
since cholesteryl esters are thought not to exchange between lipoproteins , this observation supports the hypothesis that a result of vld lipoprotein and chylomicron metabolism is the formation of ld and hd lipoproteins . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
61,
73
]
} | {
"id": "C0023825",
"name": "vld lipoprotein",
"pos": [
134,
149
]
} |
since cholesteryl esters are thought not to exchange between lipoproteins , this observation supports the hypothesis that a result of vld lipoprotein and chylomicron metabolism is the formation of ld and hd lipoproteins . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
61,
73
]
} | {
"id": "C0008731",
"name": "chylomicron",
"pos": [
154,
165
]
} |
limitations on recreational and occupational activities , the operation of a motor vehicle , what to do in the event of a seizure , questions of personality aberration and inheritance of epilepsy are other areas which need be defined for the epileptic patient . | NA | {
"id": "C0036572",
"name": "seizure",
"pos": [
122,
129
]
} | {
"id": "C0014544",
"name": "epileptic",
"pos": [
242,
251
]
} |
since the same genes affect binding of colchicine to tubulin and since the two alkaloids attach to different sites it is assumed that the somatic association suppressor gene has a broad effect on the tubulin molecules which is not confined to a single site . | NA | {
"id": "C0009262",
"name": "colchicine",
"pos": [
39,
49
]
} | {
"id": "C0002062",
"name": "alkaloids",
"pos": [
79,
88
]
} |
turnip yellow mosaic virus ( tymv ) rna treated with snake venom phosphodiesterase accepts cytidine 5'-monophosphate and adenosine 5'-monophosphate ( amp ) when it is incubated in the presence of cytidine 5'-triphosphate ( ctp ) , adenosine 5'-triphosphate , and escherichia coli transfer rna nucleotidyltransferase ; | NA | {
"id": "C0001413",
"name": "adenosine 5",
"pos": [
121,
132
]
} | {
"id": "C0001480",
"name": "adenosine",
"pos": [
231,
240
]
} |
however , newly produced rna which seems to be neither ribosomal rna nor transfer rna is detectable after illumination for 2.5 hours or longer . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
25,
28
]
} | {
"id": "C0035701",
"name": "ribosomal rna",
"pos": [
55,
68
]
} |
however , newly produced rna which seems to be neither ribosomal rna nor transfer rna is detectable after illumination for 2.5 hours or longer . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
25,
28
]
} | {
"id": "C0035711",
"name": "transfer rna",
"pos": [
73,
85
]
} |
the results obtained suggest that h ( 2 ) s may alter the interaction between the source of hydrogens on the protein moiety of the holochrome and the chromophore in vivo by reducing a disulfide bond in the protein , thereby causing a reversible conformational change in the complex . | NA | {
"id": "C0011744",
"name": "h ( 2",
"pos": [
34,
39
]
} | {
"id": "C0020275",
"name": "hydrogens",
"pos": [
92,
101
]
} |
two specific antisera against a low molecular weight form of phytochrome ( 60,000 molecular weight ) obtained from etiolated garry oat seedlings are characterized and used to compare the phytochrome preparations . | NA | {
"id": "C0250581",
"name": "a",
"pos": [
13,
14
]
} | {
"id": "C0031857",
"name": "phytochrome",
"pos": [
187,
198
]
} |
other amino acids which are derived from aspartate ( methionine , homoserine , threonine , and isoleucine ) have little effect . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
6,
17
]
} | {
"id": "C0019892",
"name": "homoserine",
"pos": [
66,
76
]
} |
when [ 8- ( 14 ) c ] -n ( 6 ) - ( delta ( 2 ) -isopentenyl ) adenosine is incubated with the endosperm of corn ( 2 weeks after pollination ) , it is converted to [ ( 14 ) c ] -n ( 6 ) - ( 4-hydroxy-3-methylbut-2-trans-enyl ) adenosine , trans-ribosylzeatin . | NA | {
"id": "C0022218",
"name": "isopentenyl",
"pos": [
47,
58
]
} | {
"id": "C0001443",
"name": "adenosine",
"pos": [
225,
234
]
} |
the cross-hybridization observed with 1.3 and 0.7 x 10 ( 6 ) molecular weight ribosomal rnas and dna , which varies greatly with different plant species , is not due to contamination of the ribosomal rnas , and is specific for the ribosomal dna of each species , probably largely restricted to those sequences coding for... | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
97,
100
]
} | {
"id": "C0012933",
"name": "ribosomal dna",
"pos": [
231,
244
]
} |
the kinetics of vanadium absorption by excised barley ( hordeum vulgare l. , cv . eire ) roots were investigated with respect to ionic species of v in solution , time and concentration dependence , ca sensitivity , and interaction with various anions , cations , and ph levels . | NA | {
"id": "C0022023",
"name": "ionic",
"pos": [
129,
134
]
} | {
"id": "C0003075",
"name": "anions",
"pos": [
244,
250
]
} |
the kinetics of vanadium absorption by excised barley ( hordeum vulgare l. , cv . eire ) roots were investigated with respect to ionic species of v in solution , time and concentration dependence , ca sensitivity , and interaction with various anions , cations , and ph levels . | NA | {
"id": "C0022023",
"name": "ionic",
"pos": [
129,
134
]
} | {
"id": "C0007447",
"name": "cations",
"pos": [
253,
260
]
} |
it is suggested that the atpase is involved in the movement of ions , particularly anions , and may be related to the anion accumulation mechanism , which is known to occur across the tonoplast of such tissues . | NA | {
"id": "C0022023",
"name": "ions",
"pos": [
63,
67
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
118,
123
]
} |
the absence of a detectable root microbody malate dehydrogenase similar to the leaf enzyme , which is intermediate in electrophoretic and chromatographic properties between the mitochondrial and soluble isoenzymes , was confirmed by diethylaminoethyl cellulose column chromatography and starch-gel electrophoresis of tot... | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
84,
90
]
} | {
"id": "C0022173",
"name": "isoenzymes",
"pos": [
203,
213
]
} |
with alpha-ketoglutarate as co-substrate , the enzyme transaminated the following aromatic amino acids : d , l-tryptophan , d , l-tyrosine , and d , l-phenylalanine , as well as the following aliphatic amino acids : d , l-alanine , d , l-methionine , and d , l-leucine . | NA | {
"id": "C0301713",
"name": "aromatic amino acids",
"pos": [
82,
102
]
} | {
"id": "C0041249",
"name": "l-tryptophan",
"pos": [
109,
121
]
} |
with alpha-ketoglutarate as co-substrate , the enzyme transaminated the following aromatic amino acids : d , l-tryptophan , d , l-tyrosine , and d , l-phenylalanine , as well as the following aliphatic amino acids : d , l-alanine , d , l-methionine , and d , l-leucine . | NA | {
"id": "C0301713",
"name": "aromatic amino acids",
"pos": [
82,
102
]
} | {
"id": "C0041485",
"name": "l-tyrosine",
"pos": [
128,
138
]
} |
with alpha-ketoglutarate as co-substrate , the enzyme transaminated the following aromatic amino acids : d , l-tryptophan , d , l-tyrosine , and d , l-phenylalanine , as well as the following aliphatic amino acids : d , l-alanine , d , l-methionine , and d , l-leucine . | NA | {
"id": "C0301713",
"name": "aromatic amino acids",
"pos": [
82,
102
]
} | {
"id": "C0031453",
"name": "l-phenylalanine",
"pos": [
149,
164
]
} |
red light causes a rapid decline of the total phytochrome level in the hook of etiolated seedlings but upon return to the dark , phytochrome again accumulates . | NA | {
"id": "C0250581",
"name": "a",
"pos": [
11,
12
]
} | {
"id": "C0031857",
"name": "phytochrome",
"pos": [
129,
140
]
} |
when ( 59 ) fe was added in vitro to ys ( 1 ) /ys ( 1 ) stem exudate , the ( 59 ) fe moved as ( 59 ) fe-citrate , indicating that sufficient citric acid was present in the exudate to chelate the fe . | NA | {
"id": "C0008857",
"name": "citrate",
"pos": [
104,
111
]
} | {
"id": "C0055819",
"name": "citric acid",
"pos": [
141,
152
]
} |
the protein content of leaves of treated plants was 15.3 % greater , and the percentages of 16 individual amino acids in the hydrolysates of the proteins of control and treated plants showed numerous differences . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
4,
11
]
} | {
"id": "C0033631",
"name": "hydrolysates",
"pos": [
125,
137
]
} |
the increase in activity of most other enzymes-phosphomonoesterase , phosphodiesterase , esterase , lipase , peroxidase , catalase , beta-glucosidase , and alpha- and beta-galactosidase-closely followed the increase in protein content . | NA | {
"id": "C0031640",
"name": "phosphodiesterase",
"pos": [
69,
86
]
} | {
"id": "C0014894",
"name": "esterase",
"pos": [
89,
97
]
} |
it is proposed that phosphoenolpyruvate carboxykinase acts as a decarboxylase during the light period , furnishing co ( 2 ) for the pentose cycle and phosphoenolpyruvate for gluconeogenesis . | NA | {
"id": "C0031644",
"name": "phosphoenolpyruvate carboxykinase",
"pos": [
20,
53
]
} | {
"id": "C0007054",
"name": "decarboxylase",
"pos": [
64,
77
]
} |
the ki for competitive inhibition of glycine uptake by another amino acid was equal to the km for the uptake of that competing species . | NA | {
"id": "C0017890",
"name": "glycine",
"pos": [
37,
44
]
} | {
"id": "C0002520",
"name": "amino acid",
"pos": [
63,
73
]
} |
by determination of the amount of racemization of aspartic acid in bones from a particular location which have been dated by the radiocarbon technique , it is possible to calculate the in situ first-order rate constant for interconversion of the l- and d enantiomers of aspartic acid . | NA | {
"id": "C0004015",
"name": "aspartic acid",
"pos": [
50,
63
]
} | {
"id": "C0949755",
"name": "d",
"pos": [
282,
283
]
} |
in general , sodium concentration in water-plants , unlike that of potassium , is not correlated with chloride but the latter is ordinarily in excess of the sodium , so that uptake of the latter implies an equivalent supply of nacl . | NA | {
"id": "C0008203",
"name": "chloride",
"pos": [
102,
110
]
} | {
"id": "C0037494",
"name": "nacl",
"pos": [
227,
231
]
} |
determination of nitrogen , sulfur , phosphorus , and carbon in solid biological materials via hydrogenation and element-selective detection . | NA | {
"id": "C0028158",
"name": "nitrogen",
"pos": [
17,
25
]
} | {
"id": "C0013879",
"name": "element",
"pos": [
113,
120
]
} |
determination of nitrogen , sulfur , phosphorus , and carbon in solid biological materials via hydrogenation and element-selective detection . | NA | {
"id": "C0031705",
"name": "phosphorus",
"pos": [
37,
47
]
} | {
"id": "C0013879",
"name": "element",
"pos": [
113,
120
]
} |
determination of nitrogen , sulfur , phosphorus , and carbon in solid biological materials via hydrogenation and element-selective detection . | NA | {
"id": "C0007009",
"name": "carbon",
"pos": [
54,
60
]
} | {
"id": "C0013879",
"name": "element",
"pos": [
113,
120
]
} |
( 3 ) h-puromycin binding is hardly affected by the 3 ' aminonucleoside of puromycin , is well inhibited by the l-phenylalanine and l-leucine analogues of puromycin and totally blocked by l-phenylalanyl-adenosine . | NA | {
"id": "C0034145",
"name": "puromycin",
"pos": [
8,
17
]
} | {
"id": "C0001443",
"name": "adenosine",
"pos": [
203,
212
]
} |
single stranded dna molecules ( 16 or 18s ) and double stranded dna fragments ( 12s ) led to t-antigen but not v-antigen synthesis . | NA | {
"id": "C0012935",
"name": "single stranded dna",
"pos": [
0,
19
]
} | {
"id": "C0012854",
"name": "double stranded dna",
"pos": [
48,
67
]
} |
the free amino acid contents in the anthers of male fertile , cytoplasmic male sterile ( cms ) and genic male sterile ( gms ) petunia lines were compared at different developmental stages of the male gametophyte . | NA | {
"id": "C0021364",
"name": "male",
"pos": [
47,
51
]
} | {
"id": "C0021359",
"name": "sterile",
"pos": [
110,
117
]
} |
quantitative differences in the amounts of free amino acids were found between the fertile and male sterile lines and between the cms and gms lines . | NA | {
"id": "C0021364",
"name": "cms",
"pos": [
130,
133
]
} | {
"id": "C0021359",
"name": "gms",
"pos": [
138,
141
]
} |
in contrast , incorporation into amino acids can account for over 60 % of the total ( 14 ) co2 fixed by young leaves in an equal time period , and incorporation into alanine alone can account for up to one half of this amount . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
33,
44
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
166,
173
]
} |
about 90 % of protein-bound hydroxyproline in the pea root segments was confined to the cell-wall fraction where it occurred as trans-4-hydroxy-l-proline . | NA | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
28,
42
]
} | {
"id": "C0033382",
"name": "proline",
"pos": [
146,
153
]
} |
externally supplied cis and trans-hydroxyproline inhibited the formation of protein-bound [ ( 14 ) c ] hydroxyproline from [ ( 14 ) c ] proline without affecting the total amount of [ ( 14 ) c ] proline incorporated into proteins . | NA | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
34,
48
]
} | {
"id": "C0033382",
"name": "proline",
"pos": [
195,
202
]
} |
studies with alphaalpha'-dipyridyl showed that , although some of the externally supplied trans- [ ( 14 ) c ] hydroxyproline was incorporated directly into cell-wall proteins , most of it was first converted into proline which was then incorporated into proteins and subsequently reconverted , in part , into hydroxyprol... | NA | {
"id": "C0033382",
"name": "proline",
"pos": [
117,
124
]
} | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
309,
323
]
} |
senescence is delayed ( chlorophyll retained ) in oat leaf sections by kinetin and benzyladenine , but not by the natural cytokinins , zeatin and isopentenyladenine . | NA | {
"id": "C0049579",
"name": "kinetin",
"pos": [
71,
78
]
} | {
"id": "C0010815",
"name": "cytokinins",
"pos": [
122,
132
]
} |
senescence is delayed ( chlorophyll retained ) in oat leaf sections by kinetin and benzyladenine , but not by the natural cytokinins , zeatin and isopentenyladenine . | NA | {
"id": "C0010815",
"name": "cytokinins",
"pos": [
122,
132
]
} | {
"id": "C0043456",
"name": "zeatin",
"pos": [
135,
141
]
} |
there is some evidence that the different isoenzymes represent conformational forms of one enzyme , and it is postulated that the gdh-i isoenzymes are correlated to a normal metabolic ( or catabolic ) function of the enzyme , whereas the gdh-ii isoenzymes are responsible for a primarily anabolic function of glutamic de... | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
45,
51
]
} | {
"id": "C0022173",
"name": "isoenzymes",
"pos": [
245,
255
]
} |
the results support the supposition that the gdh-i and gdh-ii isoenzyme patterns correspond to different molecular forms of one enzyme , the gdh-ii representing a form with predominantly anabolic function and the gdh-i a form which has merely metabolic or catabolic function . | NA | {
"id": "C0022173",
"name": "isoenzyme",
"pos": [
62,
71
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
128,
134
]
} |
proline had no effect on changes in extension growth or protein metabolism but did prevent the effects of both hydroxyproline isomers . | NA | {
"id": "C0033382",
"name": "proline",
"pos": [
0,
7
]
} | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
111,
125
]
} |
the kinetics of their synthesis together with the other data obtained strongly support the suggestion that these rna species function as precursors in the processing of ribosomal rna . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
113,
116
]
} | {
"id": "C0035701",
"name": "ribosomal rna",
"pos": [
169,
182
]
} |
the trisaccharide raffinose is , on a molar basis , more effective than the disaccharide sucrose and the latter more than the monosaccharide glucose . | NA | {
"id": "C0041102",
"name": "trisaccharide",
"pos": [
4,
17
]
} | {
"id": "C0034632",
"name": "raffinose",
"pos": [
18,
27
]
} |
the trisaccharide raffinose is , on a molar basis , more effective than the disaccharide sucrose and the latter more than the monosaccharide glucose . | NA | {
"id": "C0012611",
"name": "disaccharide",
"pos": [
76,
88
]
} | {
"id": "C0038636",
"name": "sucrose",
"pos": [
89,
96
]
} |
incubation with the alkaloids vinblastine and colchicine had no discernible effects on the ultrastructure of the sieve elements at various stages during differentiation . | NA | {
"id": "C0002062",
"name": "alkaloids",
"pos": [
20,
29
]
} | {
"id": "C0009262",
"name": "colchicine",
"pos": [
46,
56
]
} |
whereas total dna , rna and protein levels are unchanged on loss of viability , the integrity of dna and rna is impaired and ribosomal rna and soluble protein levels are reduced . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
20,
23
]
} | {
"id": "C0035701",
"name": "ribosomal rna",
"pos": [
125,
138
]
} |
shakespeare says in macbeth - `` '' the labour we delight in physics pain '' '' , and again in romeo and juliet - `` '' one fire burns out another 's burning , one pain is lessened by another 's anguish '' '' - and in 1590 montaigne wrote `` '' we feel a cut from the surgeon 's scalpel more than 10 blows of the sword i... | NA | {
"id": "C0030193",
"name": "ne p",
"pos": [
161,
165
]
} | {
"id": "C0474368",
"name": "",
"pos": [
617,
622
]
} |
it is stated that hallux valgus is the commonest of all deformities of the feet and that the operative procedures to correct this have a bad public reputation , though results are good ( wiles and sweetnam , 1965 ) . | NA | {
"id": "C0018536",
"name": "hallux valgus",
"pos": [
18,
31
]
} | {
"id": "C0016506",
"name": "of",
"pos": [
68,
70
]
} |
of 1204 fatal alcohol poisonings , 76 were due to methanol , isopropanol , ethylene glycol , or combinations of these , the rest being due to ethanol . | NA | {
"id": "C0001963",
"name": "methanol",
"pos": [
50,
58
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
142,
149
]
} |
of 1204 fatal alcohol poisonings , 76 were due to methanol , isopropanol , ethylene glycol , or combinations of these , the rest being due to ethanol . | NA | {
"id": "C0022237",
"name": "isopropanol",
"pos": [
61,
72
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
142,
149
]
} |
serum unconjugated estriol and estetrol were assayed daily in seven nondiabetic , uncomplicated third-trimester pregnancies to define the daily variation of these compounds . | NA | {
"id": "C0014927",
"name": "unconjugated estriol",
"pos": [
6,
26
]
} | {
"id": "C0014899",
"name": "estetrol",
"pos": [
31,
39
]
} |
when compared to the mean of the three preceding days ' values , or to the highest mean of three consecutive daily values previously obtained in a pregnancy , daily estriol and estetrol values fell greater than or equal to 40 % on 1.2 and 0 % of occasions , respectively . | NA | {
"id": "C0014927",
"name": "estriol",
"pos": [
165,
172
]
} | {
"id": "C0014899",
"name": "estetrol",
"pos": [
177,
185
]
} |
isolated estriol values represented falls of greater than or equal to 40 % from previously obtained single estriol values on 2 % of occasions , and no isolated estetrol values fell greater than or equal to 40 % from any other isolated values obtained in a given pregnancy . | NA | {
"id": "C0014927",
"name": "estriol",
"pos": [
9,
16
]
} | {
"id": "C0014899",
"name": "estetrol",
"pos": [
160,
168
]
} |
these results define the stability of daily serum estriol and estetrol in late-gestation normal pregnancy , although they emphasize the large variability encountered when comparing isolated estriol values . | NA | {
"id": "C0014899",
"name": "estetrol",
"pos": [
62,
70
]
} | {
"id": "C0014927",
"name": "estriol",
"pos": [
190,
197
]
} |
analysis of the effects of bone-inducing substance on the hyp mouse may help to give greater insight into the mechanism and treatment of human familial hypophosphatemia . | NA | {
"id": "C0085682",
"name": "hyp",
"pos": [
58,
61
]
} | {
"id": "C0020631",
"name": "familial",
"pos": [
143,
151
]
} |
cellular specificity of the cure for osteopetrosis : isolation of and treatment with pluripotent hemopoietic stem cells . | NA | {
"id": "C0007634",
"name": "cellular",
"pos": [
0,
8
]
} | {
"id": "C0018956",
"name": "hemopoietic stem cells",
"pos": [
97,
119
]
} |
these results suggest that the cellular source of the cure is a pluripotent hemopoietic stem cell ( phsc ) . | NA | {
"id": "C0007634",
"name": "cellular",
"pos": [
31,
39
]
} | {
"id": "C0018956",
"name": "hemopoietic stem",
"pos": [
76,
92
]
} |
the isolated cells were assayed for colony forming units -- spleen ( cfu-s ) and were found to contain approximately 65-70 % phsc . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
13,
18
]
} | {
"id": "C0018956",
"name": "phsc",
"pos": [
125,
129
]
} |
a patient with severe variant angina that was refractory to conventional treatment became symptom free when she was treated with benzhexol ( trihexyphenidyl hydrochloride ) , a cholinergic blocking agent used in the management of parkinson 's disease . | NA | {
"id": "C0041009",
"name": "benzhexol",
"pos": [
129,
138
]
} | {
"id": "C0003830",
"name": "trihexyphenidyl hydrochloride",
"pos": [
141,
170
]
} |
studies of the possible interactions between the water-soluble benzodiazepine , midazolam , and two non-depolarizing neuromuscular blocking drugs , vecuronium and tubocurarine , were performed in the rat in vivo sciatic nerve-tibialis anterior muscle preparation . | NA | {
"id": "C0005064",
"name": "benzodiazepine",
"pos": [
63,
77
]
} | {
"id": "C0026056",
"name": "midazolam",
"pos": [
80,
89
]
} |
in five cases , initially classified as refractory anaemia ( ra ) or refractory anaemia with ring sideroblasts ( ras ) , a transitory change to another type of mds -- two chronic myelomonocytic leukaemias ( cmml ) , two refractory anaemias with excess of blasts ( raeb ) and one refractory anaemia with excess of blasts ... | NA | {
"id": "C0002893",
"name": "refractory anaemia",
"pos": [
40,
58
]
} | {
"id": "C0002894",
"name": "raeb",
"pos": [
343,
347
]
} |
the enzyme also catalyzes the exchange reaction of alpha- and beta-hydrogens of the following straight-chain l-amino acids which are not susceptible to elimination : norleucine , norvaline , alpha-aminobutyrate , and alanine . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
111,
122
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
217,
224
]
} |
the exchange rates of the alpha-hydrogen and the total beta-hydrogens of l-alanine and l-alpha-aminobutyrate with deuterium followed first-order kinetics . | NA | {
"id": "C0020275",
"name": "hydrogens",
"pos": [
60,
69
]
} | {
"id": "C0011744",
"name": "deuterium",
"pos": [
114,
123
]
} |
one beta-hydrogen of s-methyl-l-cysteine was exchanged faster than the other , although both the beta-hydrogens were exchanged completely with deuterium ultimately . | NA | {
"id": "C0020275",
"name": "hydrogens",
"pos": [
102,
111
]
} | {
"id": "C0011744",
"name": "deuterium",
"pos": [
143,
152
]
} |
none of the following amino acids were susceptible to the enzymatic hydrogen exchange : d isomers of the above amino acids , branched chain l-amino acids , acidic l-amino acids , and basic l-amino acids . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
22,
33
]
} | {
"id": "C0002521",
"name": "branched chain",
"pos": [
125,
139
]
} |
none of the following amino acids were susceptible to the enzymatic hydrogen exchange : d isomers of the above amino acids , branched chain l-amino acids , acidic l-amino acids , and basic l-amino acids . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
22,
33
]
} | {
"id": "C0815040",
"name": "acidic",
"pos": [
156,
162
]
} |
none of the following amino acids were susceptible to the enzymatic hydrogen exchange : d isomers of the above amino acids , branched chain l-amino acids , acidic l-amino acids , and basic l-amino acids . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
22,
33
]
} | {
"id": "C0301714",
"name": "basic",
"pos": [
183,
188
]
} |
when viewed within the context of other recent studies involving neutral glycosphingolipids , these findings provide additional evidence for the existence of microscopic , glycosphingolipid-enriched domains within the phospholipid bilayer . | NA | {
"id": "C0600570",
"name": "neutral glycosphingolipids",
"pos": [
65,
91
]
} | {
"id": "C0017978",
"name": "glycosphingolipid",
"pos": [
172,
189
]
} |
factor xii , factor xiia , and the 40-kilodalton binding fragment of factor xii bound tightly to all of the negatively charged lipids investigated , including sulfatide , phosphatidylserine , and phosphatidylethanolamine , but not to the neutral lipid phosphatidylcholine . | NA | {
"id": "C0015527",
"name": "factor xiia",
"pos": [
13,
24
]
} | {
"id": "C0015525",
"name": "factor xii",
"pos": [
69,
79
]
} |
epitopes to which neutralizing monoclonal antibodies u3 , u4 , and u5 and nonneutralizing antibody u6 were directed were readily distinguished by cross-reactivity with ifn alpha subtypes . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
31,
52
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
90,
98
]
} |
when incorporated into immune complexes , the modified antibody also retains fc receptor recognition ability as determined by erythrocyte-antibody rosette inhibition assays . | NA | {
"id": "C0003313",
"name": "immune",
"pos": [
23,
29
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
138,
146
]
} |
analysis of phosphopeptides isolated from profilaggrin showed that 66 % of the phosphate was located on peptides that are unphosphorylated in filaggrin . | NA | {
"id": "C0031684",
"name": "phosphopeptides",
"pos": [
12,
27
]
} | {
"id": "C0030956",
"name": "peptides",
"pos": [
104,
112
]
} |
on the basis of four criteria ( electroporetic mobility , membrane location , binding of concanavalin a , and mobility shifts with sh oxidation ) , the 220-kda protein appears to correspond to the membrane protein previously identified at the rims of rod disks [ papermaster , d.s. , schneider , b.g. , zorn , m.a . & kr... | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
160,
167
]
} | {
"id": "C0025252",
"name": "membrane protein",
"pos": [
197,
213
]
} |
while d-glucose mutarotation is more rapid at this temperature , the anomers of d-glucose are not transported differently by the red cell hexose transfer system . | NA | {
"id": "C0017725",
"name": "glucose",
"pos": [
8,
15
]
} | {
"id": "C0019494",
"name": "hexose",
"pos": [
138,
144
]
} |
human factor viii : c has been purified over 300 000-fold from cryoprecipitate by polyelectrolyte purification followed by affinity chromatography on sepharose linked to antibody to factor viiir : ag ( monoclonal or polyclonal ) and sepharose linked to monoclonal antibody to factor viii : c . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
170,
178
]
} | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
253,
272
]
} |
it increased with increasing concentrations of either the lipid vesicles or the virions . pretreatment of virions with increasing concentrations of three different proteolytic enzymes ( trypsin , chymotrypsin and proteinase ) inhibited the virus ' ability to cause release of carboxyfluorescein from negatively charged l... | NA | {
"id": "C0030940",
"name": "proteolytic enzymes",
"pos": [
164,
183
]
} | {
"id": "C0030946",
"name": "proteinase",
"pos": [
213,
223
]
} |
in the range of antibiotic concentration where permeability was induced , r greater than 0.1 for epc vesicles , r greater than 0.06 for dppc vesicles , etruscomycin exhibited characteristic circular dichroism spectra independent of the presence of sterol . | NA | {
"id": "C1959616",
"name": "epc",
"pos": [
97,
100
]
} | {
"id": "C0000039",
"name": "dppc",
"pos": [
136,
140
]
} |
lower concentrations of globoside , or higher concentrations of ceramide tri- , di- , or monohexoside , were not inhibitory . | NA | {
"id": "C0017647",
"name": "globoside",
"pos": [
24,
33
]
} | {
"id": "C0007745",
"name": "ceramide",
"pos": [
64,
72
]
} |
at a globoside concentration of 5.8 % , inhibition of the monoclonal antibody activity was reduced and inhibition was related to antibody concentration ; | NA | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
58,
77
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
129,
137
]
} |
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