text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
surgically correctable hypertension has also been reported in some patients with large renal cysts and renal tumors ( hemangiopericytoma , wilm 's tumor , hypernephroma , renal pelvic tumor ) . | NA | {
"id": "C0022665",
"name": "renal tumors",
"pos": [
103,
115
]
} | {
"id": "C0027708",
"name": "wilm 's tumor",
"pos": [
139,
152
]
} |
immunohistochemical and biochemical study on the development of the noradrenaline- and adrenaline-storing cells of the adrenal medulla of the rat . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
68,
81
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
87,
97
]
} |
immunohistochemistry involved the use of antibodies to noradrenaline ( na ) , adrenaline ( a ) and the biosynthesizing enzymes dopamine beta-hydroxylase ( dbh ) and phenylethanolamine n-methyltransferase ( pnmt ) . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
55,
68
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
78,
88
]
} |
during the second period , from the 18th prenatal day to 2 or 3 days after birth , all medullary cells were immunoreactive to dbh , na , pnmt and a , and during this phase the adrenaline concentration increased daily and became the predominant amine on the 20th day of gestation . | NA | {
"id": "C0028351",
"name": "na",
"pos": [
44,
46
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
176,
186
]
} |
seventy-eight gram-negative non-fermentative bacilli have been tested against eight antimicrobial agents ( wide spectrum penicillins , newer generation cephalosporins and aminoglycosides ) . | NA | {
"id": "C1136254",
"name": "antimicrobial agents",
"pos": [
84,
104
]
} | {
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
171,
186
]
} |
the oral single-dose studies of lapc ( equivalent to 250 mg anpc ) and of ampc ( 500 mg ) demonstrated that the mean peak serum concentrations of abpc and ampc were 11.4 +/- 0.8 micrograms/ml at 40 min and 8.5 +/- 0.7 micrograms/ml at 50-90 min , respectively . | NA | {
"id": "C0002680",
"name": "abpc",
"pos": [
146,
150
]
} | {
"id": "C0002645",
"name": "ampc",
"pos": [
155,
159
]
} |
others have suggested that reaction instead occurs with lysine moieties of axonal cytoskeletal proteins to form alkyl pyrrole adducts , leading to damaging physicochemical changes in these proteins . | NA | {
"id": "C0010852",
"name": "cytoskeletal proteins",
"pos": [
82,
103
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
189,
197
]
} |
transport of the probe ion pr3+ across egg yolk phosphatidylcholine ( pc ) and dipalmitoyl phosphatidylcholine ( dppc ) vesicular membranes in the presence of the channel forming polypeptides alamethicin 30 and melittin , and the polyene antibiotic nystatin , as well as the degree of vesicular lysis at the gel to liqui... | NA | {
"id": "C1959616",
"name": "phosphatidylcholine",
"pos": [
48,
67
]
} | {
"id": "C0000039",
"name": "dppc",
"pos": [
350,
354
]
} |
however , at a 20-fold higher peroxidase concentration hes and m-des showed metabolic conversion whereas dm-des did not . | NA | {
"id": "C0019467",
"name": "hes",
"pos": [
55,
58
]
} | {
"id": "C0012203",
"name": "des",
"pos": [
108,
111
]
} |
effects of extracts of leaves of artemisia species , and caffeic acid and chlorogenic acid on lipid metabolic injury in rats fed peroxidized oil . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
94,
99
]
} | {
"id": "C0028908",
"name": "oil",
"pos": [
141,
144
]
} |
the main metabolite of spin-labeled thio-tepa is spin-labeled tepa , where oxidative desulfurization is invoked as the main metabolic mechanism . | NA | {
"id": "C0039871",
"name": "thio-tepa",
"pos": [
36,
45
]
} | {
"id": "C0039533",
"name": "tepa",
"pos": [
62,
66
]
} |
an analogue of doxorubicin , 4'-epi-doxorubicin , also inhibits the rate of dna synthesis within 1 h after treatment with 16 microm , to the same extent as doxorubicin-treatment of myocardial cells . | NA | {
"id": "C0014582",
"name": "4",
"pos": [
29,
30
]
} | {
"id": "C0013089",
"name": "doxorubicin",
"pos": [
156,
167
]
} |
furthermore , similarity between doxorubicin and 4'-epi-doxorubicin in their effect on the myocardial thymidylate pool was also demonstrated by a significantly decreased incorporation of total [ methyl-3h ] thymidine . | NA | {
"id": "C0013089",
"name": "doxorubicin",
"pos": [
33,
44
]
} | {
"id": "C0014582",
"name": "4",
"pos": [
49,
50
]
} |
light microscopy of doxorubicin- and 4'-epi-doxorubicin-treated myocardial cells and doxorubicin-treated skeletal muscle cells showed distinct nucleolar fragmentation and revealed no differences between the two drugs in their effect on either myocardial or skeletal muscle cells . | NA | {
"id": "C0014582",
"name": "4",
"pos": [
37,
38
]
} | {
"id": "C0013089",
"name": "doxorubicin",
"pos": [
85,
96
]
} |
future studies should test the possibility that ifosfamide-containing combination chemotherapy may be more effective than the regimens , usually including cyclophosphamide , that are currently used as front-line treatment of embryonal and ewing 's sarcoma . | NA | {
"id": "C0020823",
"name": "ifosfamide",
"pos": [
48,
58
]
} | {
"id": "C0010583",
"name": "cyclophosphamide",
"pos": [
155,
171
]
} |
differential renal tumor response to n-ethylnitrosourea and dimethylnitrosamine in the nb rat : basis for a new rodent model of nephroblastoma . | NA | {
"id": "C0022665",
"name": "renal tumor",
"pos": [
13,
24
]
} | {
"id": "C0027708",
"name": "nephroblastoma",
"pos": [
128,
142
]
} |
in order to determine whether this inherent susceptibility could be exploited as a model for wilms ' tumor , nb rats were treated with various chemicals in regimens known to be associated with renal tumor induction in the young rat . | NA | {
"id": "C0027708",
"name": "wilms",
"pos": [
93,
98
]
} | {
"id": "C0022665",
"name": "renal tumor",
"pos": [
193,
204
]
} |
transplancental enu at a dose of 60 mg/kg resulted in an average of 50 % frequency of unequivocal nephroblastomas in both sexes with no renal mesenchymal tumors . | NA | {
"id": "C0027708",
"name": "nephroblastomas",
"pos": [
98,
113
]
} | {
"id": "C0022665",
"name": "renal",
"pos": [
136,
141
]
} |
in contrast , dmn administered to neonates produced a similar incidence of renal mesenchymal tumors but no nephroblastomas . | NA | {
"id": "C0022665",
"name": "renal",
"pos": [
75,
80
]
} | {
"id": "C0027708",
"name": "nephroblastomas",
"pos": [
107,
122
]
} |
dmba in the ovariectomized female was not a successful strategy for inducing primary renal tumors in the nb rat ( 0 nephroblastomas , 1 renal mesenchymal tumor in 16 effective survivors ) , although the kidney was sometimes the site for metastatic invasion by tumors originating at other locations . | NA | {
"id": "C0027708",
"name": "nephroblastomas",
"pos": [
116,
131
]
} | {
"id": "C0022665",
"name": "renal",
"pos": [
136,
141
]
} |
the induction of nephroblastomas and renal mesenchymal tumors by enu and dmn in parallel experiments emphasized the many differences which establish them as distinct and unrelated tumor entities . | NA | {
"id": "C0027708",
"name": "nephroblastomas",
"pos": [
17,
32
]
} | {
"id": "C0022665",
"name": "renal",
"pos": [
37,
42
]
} |
however , ascorbic acid prevents the mutagenicity of mnng in vitro if added to bacteria in a medium prepared with either sterile tap water or deionized water and cu2+ ions and that this antimutagenic response is blocked by edta . | NA | {
"id": "C0359299",
"name": "sterile",
"pos": [
121,
128
]
} | {
"id": "C0043047",
"name": "water",
"pos": [
152,
157
]
} |
in both assays the phorbol esters 12-o-tetradecanoylphorbol-13-acetate ( tpa ) and phorbol-12,13-dibutyrate ( pdbu ) inhibited intercellular communication completely at 1 ng/ml . | NA | {
"id": "C0031586",
"name": "phorbol esters",
"pos": [
19,
33
]
} | {
"id": "C0039654",
"name": "12-o-tetradecanoylphorbol-13-acetate",
"pos": [
34,
70
]
} |
skin tumor-promoting agents , including the 12-o-tetradecanoylphorbol-13-acetate ( tpa ) -type tumor promoters , such as diterpine phorbol esters , teleocidin and aplysiatoxin , and a non-tpa-type tumor promoter ( the newly described palytoxin , present in the coelenterate of the genus palythoa ) , stimulated arachidon... | NA | {
"id": "C0039654",
"name": "12-o-tetradecanoylphorbol-13-acetate",
"pos": [
44,
80
]
} | {
"id": "C0031586",
"name": "phorbol esters",
"pos": [
131,
145
]
} |
plasma lactate concentrations , in contrast , showed components related both to severity of injury and independently to norepinephrine and epinephrine concentrations . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
120,
134
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
139,
150
]
} |
we have examined the effect of e coli endotoxin infusion ( 41 micrograms kg-1 min-1 iv for 4 h ) on plasma concentrations of epinephrine ( e ) , norepinephrine ( ne ) , and dopamine ( da ) in the conscious unrestrained rat . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
125,
136
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
145,
159
]
} |
captopril abolished the increases in arterial pressure , hindquarters , and left renal resistance , but both bradycardia and increased mesenteric resistance persisted , indicating that baroreflex activation might be buffering a non-renin-angiotensin system pro-hypertensive mechanism . | NA | {
"id": "C0006938",
"name": "captopril",
"pos": [
0,
9
]
} | {
"id": "C0033382",
"name": "pro",
"pos": [
257,
260
]
} |
the significance of this atrial myosin heavy chain polymorphism is discussed in relation to the existence of anatomical localizations of the two myosin variants . | NA | {
"id": "C0027100",
"name": "myosin",
"pos": [
32,
38
]
} | {
"id": "C0027096",
"name": "myosin",
"pos": [
145,
151
]
} |
pollens of closely related species often share common antigens and allergens although this is not always the case . | NA | {
"id": "C0003320",
"name": "antigens",
"pos": [
54,
62
]
} | {
"id": "C0002092",
"name": "allergens",
"pos": [
67,
76
]
} |
analytical recovery is about 94 % for epinephrine , 91 % for norepinephrine , with a cv of approximately 5 % . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
38,
49
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
61,
75
]
} |
we separated bound from free 25-hydroxy- [ 3h ] cholecalciferol by using a second antibody : goat antiserum to rabbit serum . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
82,
90
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
98,
107
]
} |
radioenzymatic microassay for simultaneous estimations of dopamine , norepinephrine , and epinephrine in plasma , urine , and tissues . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
69,
83
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
90,
101
]
} |
with this sensitive and specific radioenzymatic assay picogram quantities of norepinephrine , epinephrine , and dopamine can be simultaneously determined directly in plasma , urine , and tissue . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
77,
91
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
94,
105
]
} |
in this simultaneous assay of unbound phenobarbital , phenytoin , primidone , and carbamazepine , serum ultrafiltrate is prepared by centrifugation in disposable filter units ( centrifree micropartition system , amicon corp. ) and injected directly onto a reversed-phase liquid-chromatography column . | NA | {
"id": "C0031412",
"name": "phenobarbital",
"pos": [
38,
51
]
} | {
"id": "C0033148",
"name": "primidone",
"pos": [
66,
75
]
} |
the molecular mass of albumin , the protein present in highest concentration in serum , is near the glomerular filtration threshold , and this protein is not reabsorbed by renal tubules ; | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
22,
29
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
143,
150
]
} |
free enzyme was not detected in serum , and the activity of the complexed enzyme was probably unaltered on binding with the immunoglobulins . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
5,
11
]
} | {
"id": "C0026741",
"name": "complexed enzyme",
"pos": [
64,
80
]
} |
benzoylalanine : detection and identification of an alanine conjugate with benzoic acid in hyperammonemic patients treated with sodium benzoate . | NA | {
"id": "C0053225",
"name": "benzoic acid",
"pos": [
75,
87
]
} | {
"id": "C0142805",
"name": "sodium benzoate",
"pos": [
128,
143
]
} |
after separation of cell proteins from control fibroblasts by sodium dodecyl sulphate/polyacrylamide gel electrophoresis and fluorography , a prominent 55 kilodalton band was evident in cell extracts treated with the antiserum which corresponded to lipoamide dehydrogenase . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
47,
58
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
186,
190
]
} |
the 2-3-fold increase in acidic alpha-mannosidase in pregnancy is due to an increase in the most negatively charged form of acidic alpha-mannosidase , b2 , which is slightly more negatively charged than its counterpart in the control plasma . | NA | {
"id": "C0024746",
"name": "mannosidase",
"pos": [
38,
49
]
} | {
"id": "C0051350",
"name": "alpha-mannosidase",
"pos": [
131,
148
]
} |
an immunoassay for prostatic acid phosphatase is described in which a high degree of specificity for the prostatic isoenzyme , obtained by the use of monoclonal antibodies , is combined with great sensitivity , made possible by enzyme-amplified measurement of the combination of the isoenzyme with its antibody . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
150,
171
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
302,
310
]
} |
the effect of pregnancy or hepatocellular function is variable , but , when evidence of liver failure is present in the first trimester , termination should be considered . | NA | {
"id": "C0032961",
"name": "pregnancy",
"pos": [
14,
23
]
} | {
"id": "C0032979",
"name": "first trimester",
"pos": [
120,
135
]
} |
in an aliquot of the pronase digest , the specific radioactivity of 14c-proline and 14c-hydroxyproline were determined . | NA | {
"id": "C0033382",
"name": "proline",
"pos": [
72,
79
]
} | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
88,
102
]
} |
3 months treatment with colchicine did not modify the total amounts of proline and hydroxyproline in skin proteins , but diminished the amount of the gags as expressed by uronic acid content . | NA | {
"id": "C0033382",
"name": "proline",
"pos": [
71,
78
]
} | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
83,
97
]
} |
colchicine treatment decreased also the specific radioactivity of proline and hydroxyproline , which reflects a decrease of total protein and collagen synthesis . | NA | {
"id": "C0033382",
"name": "proline",
"pos": [
66,
73
]
} | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
78,
92
]
} |
the leucoprep tube is a 7-ml glass tube which contains a polyester gel and a solution of a sucrose polymer and sodium diatrizoate ( histopaque , sigma ) . | NA | {
"id": "C0032474",
"name": "polyester",
"pos": [
57,
66
]
} | {
"id": "C0032521",
"name": "polymer",
"pos": [
99,
106
]
} |
21 of these had tumours of the glioma group ( 17 astrocytomas who i-iii and oligoastrocytomas , 4 glioblastomas ) . | NA | {
"id": "C0004114",
"name": "astrocytomas",
"pos": [
49,
61
]
} | {
"id": "C0017636",
"name": "glioblastomas",
"pos": [
98,
111
]
} |
an essential advantage offered by mr is , besides the absence of exposure to radiation , in the first place the better and more precise information on the relative position of the adenoma with reference to the vessels and the optic chiasm , and , secondly , better identification of cystic and haemorrhagic processes wit... | NA | {
"id": "C0001430",
"name": "adenoma",
"pos": [
180,
187
]
} | {
"id": "C0033375",
"name": "prolactinoma",
"pos": [
328,
340
]
} |
treatment of monolayers of chick embryo hepatocytes with the calcium channel blocking drugs nifedipine and verapamil resulted in a decrease in the activity of uroporphyrinogen decarboxylase , an increase in the activity of delta-aminolaevulinate synthase and accumulation of porphyrins with uroporphyrin and heptacarboxy... | NA | {
"id": "C0032712",
"name": "porphyrins",
"pos": [
275,
285
]
} | {
"id": "C0042093",
"name": "uroporphyrin",
"pos": [
291,
303
]
} |
the infections most commonly encountered in patients with aids are pneumocystis carinii pneumonia ( 58 % ) , candida esophagitis ( 31 % ) , toxoplasmosis ( 21 % ) , cytomegalovirus infections ( 15 % ) , and herpes-simplex virus infections ( 12 % ) . | NA | {
"id": "C0010823",
"name": "cytomegalovirus infections",
"pos": [
165,
191
]
} | {
"id": "C0019372",
"name": "herpes-simplex virus",
"pos": [
207,
227
]
} |
patients with pregnancy-induced hypertension ( pih ) and healthy pregnant and non-pregnant women were compared with regard to cardiovascular responses to i.v . infusions of noradrenaline ( na ) and adrenaline ( adr ) . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
173,
186
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
198,
208
]
} |
bullous pemphigoid , cicatricial pemphigoid , and epidermolysis bullosa acquisita are three autoimmune diseases characterized by the presence of subepidermal blisters , in vivo-bound immunoreactants along the dermoepidermal junction , and variably detectable circulating anti-basement membrane autoantibodies . | NA | {
"id": "C0030805",
"name": "bullous pemphigoid",
"pos": [
0,
18
]
} | {
"id": "C0004364",
"name": "autoimmune diseases",
"pos": [
92,
111
]
} |
the properties of the membrane-bound calcium-pumping protein , the ( ca2+ + mg2+ ) -atpase ( atp phosphohydrolase , ec 3.6.1.3 ) were compared in erythrocyte ghosts isolated from five mammalian species -- human ( homo sapiens ) , bovine ( bos taurus ) , porcine ( sus scrofa melitensis ) , ovine ( ovis aries crassicandu... | NA | {
"id": "C0001476",
"name": "calcium-pumping",
"pos": [
37,
52
]
} | {
"id": "C0001473",
"name": "atp phosphohydrolase",
"pos": [
93,
113
]
} |
these antibodies were shown to be as sensitive as polyclonal antiserum in detecting avidin by radioimmunoassay ( ria ) and enzyme linked immunosorbent assay ( elisa ) methods . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
6,
16
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
61,
70
]
} |
the hexose ( galactose + mannose ) content of macaca transferrin is 4.7 mole per mole of protein . | NA | {
"id": "C0019494",
"name": "hexose",
"pos": [
4,
10
]
} | {
"id": "C0016945",
"name": "galactose",
"pos": [
13,
22
]
} |
the hexose ( galactose + mannose ) content of macaca transferrin is 4.7 mole per mole of protein . | NA | {
"id": "C0019494",
"name": "hexose",
"pos": [
4,
10
]
} | {
"id": "C0024742",
"name": "mannose",
"pos": [
25,
32
]
} |
the results presented are consistent with a random combination of reactants with the fdp-modified mg2+-activated enzyme and the formation of the dead-end complexes enzyme adp-atp and enzyme-pep-atp . | NA | {
"id": "C0026741",
"name": "complexes enzyme",
"pos": [
154,
170
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
183,
189
]
} |
all three pepsinogens contained glycine as n-terminal amino acid , but differed in their overall amino acid compositions . | NA | {
"id": "C0017890",
"name": "glycine",
"pos": [
32,
39
]
} | {
"id": "C0002520",
"name": "amino acid",
"pos": [
97,
107
]
} |
treatment with gag-specific enzymes followed by electrophoretic analysis showed that both the carcass and tegument contained heparin and/or heparan sulfate , chondroitin sulfate and hyaluronic acid . | NA | {
"id": "C0017973",
"name": "gag",
"pos": [
15,
18
]
} | {
"id": "C0019134",
"name": "heparin",
"pos": [
125,
132
]
} |
treatment with gag-specific enzymes followed by electrophoretic analysis showed that both the carcass and tegument contained heparin and/or heparan sulfate , chondroitin sulfate and hyaluronic acid . | NA | {
"id": "C0017973",
"name": "gag",
"pos": [
15,
18
]
} | {
"id": "C0019143",
"name": "heparan sulfate",
"pos": [
140,
155
]
} |
a tropomyosin isoform ( mr 41k ) and three troponin subunits identified as troponin t ( mr 37.5k ) , troponin i ( mr 25.5k ) and troponin c ( mr 18.5k ) were purified . | NA | {
"id": "C0041199",
"name": "troponin",
"pos": [
43,
51
]
} | {
"id": "C0077404",
"name": "troponin t",
"pos": [
75,
85
]
} |
a tropomyosin isoform ( mr 41k ) and three troponin subunits identified as troponin t ( mr 37.5k ) , troponin i ( mr 25.5k ) and troponin c ( mr 18.5k ) were purified . | NA | {
"id": "C0041199",
"name": "troponin",
"pos": [
43,
51
]
} | {
"id": "C0077401",
"name": "troponin i",
"pos": [
101,
111
]
} |
epinephrine , in turn , stimulates the release of norepinephrine , and probably also of dopamine , from other cardiovascular chromaffin cells . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
0,
11
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
50,
64
]
} |
anion-exchange chromatography ( deae-sephacel ) of material having a ve/vo of 1.7-1.9 revealed a major cd-peak corresponding to rat cd , zn-mt ( i ) and a minor peak corresponding to cd , zn-mt ( ii ) . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
0,
5
]
} | {
"id": "C0021966",
"name": "i",
"pos": [
197,
198
]
} |
lipogenesis was inhibited by adrenergic agonists : epinephrine ( alpha + beta ) greater than isoproterenol ( beta 1/beta 2 ) greater than norepinephrine ( alpha 1/alpha 2 , beta 1 ) greater than metaproterenol ( beta 2 ) , phenylephrine ( alpha 1 ) . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
51,
62
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
138,
152
]
} |
rainbow trout brain extracts contained cck-li that co-eluted with cck-8 in gel permeation chromatography whereas cck-li extracted from the various gut regions exhibited marked molecular heterogeneity . | NA | {
"id": "C0037167",
"name": "cck-8",
"pos": [
66,
71
]
} | {
"id": "C0008328",
"name": "cck-li",
"pos": [
113,
119
]
} |
plasma concentrations of adrenaline and noradrenaline were measured at rest from cannulated fish and following net capture . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
25,
35
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
40,
53
]
} |
adrenaline and noradrenaline concentrations in capture-stressed fish averaged 36,740 pmol l-1 and 38,860 pmol l-1 respectively , whereas resting values were less than 200 pmol l-1 for both amines . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
0,
10
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
15,
28
]
} |
biogenic amine uptake by nerve cords from the american cockroach and the influence of amidines on amine uptake and release . | NA | {
"id": "C0005496",
"name": "biogenic amine",
"pos": [
0,
14
]
} | {
"id": "C0002508",
"name": "amine",
"pos": [
98,
103
]
} |
12 out of the 25 patients presented hypokinesis , akinesis or dyskinesis of at least two segments ; | NA | {
"id": "C0086439",
"name": "hypokinesis",
"pos": [
36,
47
]
} | {
"id": "C0013384",
"name": "dyskinesis",
"pos": [
62,
72
]
} |
amino acids predominantly present at the n terminus of n alpha-acetylated proteins are alanine , serine , and methionine . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
0,
11
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
87,
94
]
} |
in eukaryotes , an abundant population of promoter-proximal rna chains have been observed and studied , mainly in whole nuclear rna , in denovirus type 2 , and in sv40 . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
60,
63
]
} | {
"id": "C0035700",
"name": "nuclear rna",
"pos": [
120,
131
]
} |
the adverse effects of alkalemia were largely explained by increases in whole-blood bicarbonate , plasma sodium , and plasma osmolality after administration of sodium bicarbonate . | NA | {
"id": "C0005367",
"name": "bicarbonate",
"pos": [
84,
95
]
} | {
"id": "C0074722",
"name": "sodium bicarbonate",
"pos": [
160,
178
]
} |
and one of nine patients with tachycardia was tested noninvasively for likelihood of recurrent ventricular tachycardia . | NA | {
"id": "C0039231",
"name": "tachycardia",
"pos": [
30,
41
]
} | {
"id": "C0042514",
"name": "ventricular tachycardia",
"pos": [
95,
118
]
} |
retinal angiomatosis and pancreatic cysts in von hippel-lindau disease : use of computed tomography scanning for diagnosis and surveillance . | NA | {
"id": "C0002992",
"name": "angiomatosis",
"pos": [
8,
20
]
} | {
"id": "C0019562",
"name": "von hippel-lindau disease",
"pos": [
45,
70
]
} |
baroinjury is discussed in terms of alterations of the lipid leaflet or of membrane proteins , and the mechanism of baroprotection in terms of stabilization of membrane components , under the effect of high pressure , by the association of glycerol with the proteins or the phosphate head groups of phospholipids . | NA | {
"id": "C0025252",
"name": "membrane proteins",
"pos": [
75,
92
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
258,
266
]
} |
the medicinal properties of garlic and onion oils have been much studied over the last decade and the review will include critical assessment of this area and also will touch on the more general properties ( antimicrobial , antifungal , antibacterial , and insecticidal ) of these oils . | NA | {
"id": "C1136254",
"name": "antimicrobial",
"pos": [
208,
221
]
} | {
"id": "C0003308",
"name": "antifungal",
"pos": [
224,
234
]
} |
after negative results of patch tests to other imidazoles , the patient was treated with econazole without complications . | NA | {
"id": "C0020924",
"name": "imidazoles",
"pos": [
47,
57
]
} | {
"id": "C0013547",
"name": "econazole",
"pos": [
89,
98
]
} |
hla-typing is a valuable tool in the identification of the haemochromatosis genotype in a family , and it is an adjunct to the biochemical screening procedure in relatives of patients with this iron overload disorder . | NA | {
"id": "C0018995",
"name": "haemochromatosis",
"pos": [
59,
75
]
} | {
"id": "C0282193",
"name": "iron overload",
"pos": [
194,
207
]
} |
minimum inhibitory concentrations and minimum bactericidal concentrations were determined for cefotaxime , gentamicin , tobramycin and amikacin and for the combination of cefotaxime and each of the aminoglycosides in vitro against 200 strains of enterobacteriaceae . | NA | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
107,
117
]
} | {
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
198,
213
]
} |
older children were more accurate than younger children on nursery school targets , but children 's spatial representations were relatively nonintegrated at both age levels . | NA | {
"id": "C1455726",
"name": "older",
"pos": [
0,
5
]
} | {
"id": "C0008059",
"name": "children 's",
"pos": [
88,
99
]
} |
in all 24 patients with severe hyperthyroidism , including three patients with thyroid storm , hormone levels decreased within a few days after surgery to normal or subnormal values and the clinical picture of thyrotoxicosis disappeared . | NA | {
"id": "C0020550",
"name": "hyperthyroidism",
"pos": [
31,
46
]
} | {
"id": "C0040156",
"name": "thyrotoxicosis",
"pos": [
210,
224
]
} |
in all 24 patients with severe hyperthyroidism , including three patients with thyroid storm , hormone levels decreased within a few days after surgery to normal or subnormal values and the clinical picture of thyrotoxicosis disappeared . | NA | {
"id": "C0040127",
"name": "thyroid storm",
"pos": [
79,
92
]
} | {
"id": "C0040156",
"name": "thyrotoxicosis",
"pos": [
210,
224
]
} |
prenucleolar bodies , whether naturally occurring or induced by actinomycin d treatment , stain with silver and contain phosphoproteins b23 and c23 , two of the major proteins of the interphase nucleolus as determined by double label immunofluorescence with specific antibodies . | NA | {
"id": "C0031689",
"name": "phosphoproteins",
"pos": [
120,
135
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
167,
175
]
} |
endoscopy and biopsy of the upper gastrointestinal tract and terminal ileum were performed in 24 patients with familial polyposis or gardner 's syndrome in order to further define the incidence of extracolonic adenomatous polyps . | NA | {
"id": "C0032580",
"name": "familial polyposis",
"pos": [
111,
129
]
} | {
"id": "C0206677",
"name": "adenomatous polyps",
"pos": [
210,
228
]
} |
gastric mucosa of ulcer patients tends to generate smaller amounts of pgs of e and i series and exhibits a reduced ratio of pg to thromboxane generation , which suggests that the deficiency of protective pg may play a role in the pathogenesis of peptic ulcer . | NA | {
"id": "C0033555",
"name": "a",
"pos": [
1,
2
]
} | {
"id": "C0033554",
"name": "pg",
"pos": [
204,
206
]
} |
absorption , metabolism and excretion of radiolabelled misoprostol were studied in laboratory animals and in humans . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
13,
23
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
28,
37
]
} |
gastric inhibitory polypeptide ( gip ) is a gastrointestinal hormone stimulated after oral nutrient ingestion , but not after intravenous nutrient administration . | NA | {
"id": "C0017132",
"name": "gip",
"pos": [
33,
36
]
} | {
"id": "C0017182",
"name": "gastrointestinal hormone",
"pos": [
44,
68
]
} |
we have examined in 20 type i diabetic subjects the efficacy of tolazamide , a common sulfonylurea agent , as adjuvant therapy in combination with an appropriate diet and insulin . | NA | {
"id": "C0040372",
"name": "tolazamide",
"pos": [
64,
74
]
} | {
"id": "C0038766",
"name": "sulfonylurea",
"pos": [
86,
98
]
} |
the stereoselective distribution , metabolism , and excretion of 2-phenylpropionic acid ( hydratropic acid , hta ) was studied by giving racemic hta ( 20 mg/kg ) to intact , bile duct-cannulated , bile duct-ligated , and nephrectomized and bile duct-cannulated rats . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
35,
45
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
52,
61
]
} |
although mechanical stone removal is still considered to be the treatment of choice for retained gallstones , monooctanoin use appears promising for stone dissolution in patients in whom mechanical removal has been unsuccessful or is impossible . | NA | {
"id": "C0008350",
"name": "gallstones",
"pos": [
97,
107
]
} | {
"id": "C0006736",
"name": "stone",
"pos": [
149,
154
]
} |
the onset of symptoms was consistent with the rate of decline of diazepam and its active metabolite , desmethyldiazepam . | NA | {
"id": "C0012010",
"name": "diazepam",
"pos": [
65,
73
]
} | {
"id": "C0011279",
"name": "desmethyldiazepam",
"pos": [
102,
119
]
} |
the apparent first-order elimination suggests that hce metabolism and excretion were not saturated in rats given up to 62 mg/kg/day and suggests that , in the range of doses given , toxicity should be proportional to exposure concentration . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
55,
65
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
70,
79
]
} |
chlorinated hydrocarbons found in a bioassay to be carcinogenic to both b6c3f1 mice and osborne-mendel rats ( 1,2-dichloroethane ) , carcinogenic only to mice ( 1,1,2-trichloroethane , 1,1,2,2-tetrachloroethane , hexachloroethane , trichloroethylene , and tetrachloroethylene ) , and noncarcinogenic to either species ( ... | NA | {
"id": "C0020247",
"name": "chlorinated hydrocarbons",
"pos": [
0,
24
]
} | {
"id": "C0040905",
"name": "trichloroethylene",
"pos": [
232,
249
]
} |
chlorinated hydrocarbons found in a bioassay to be carcinogenic to both b6c3f1 mice and osborne-mendel rats ( 1,2-dichloroethane ) , carcinogenic only to mice ( 1,1,2-trichloroethane , 1,1,2,2-tetrachloroethane , hexachloroethane , trichloroethylene , and tetrachloroethylene ) , and noncarcinogenic to either species ( ... | NA | {
"id": "C0020247",
"name": "chlorinated hydrocarbons",
"pos": [
0,
24
]
} | {
"id": "C0039637",
"name": "tetrachloroethylene",
"pos": [
256,
275
]
} |
chlorinated hydrocarbons found in a bioassay to be carcinogenic to both b6c3f1 mice and osborne-mendel rats ( 1,2-dichloroethane ) , carcinogenic only to mice ( 1,1,2-trichloroethane , 1,1,2,2-tetrachloroethane , hexachloroethane , trichloroethylene , and tetrachloroethylene ) , and noncarcinogenic to either species ( ... | NA | {
"id": "C0020247",
"name": "chlorinated hydrocarbons",
"pos": [
0,
24
]
} | {
"id": "C0040904",
"name": "trichloroethane",
"pos": [
349,
364
]
} |
formulae were constructed to predict gfr in the first month of life from postnatal age ( pa ) , weight and birthweight ( bw ) ; | NA | {
"id": "C0005910",
"name": "weight",
"pos": [
96,
102
]
} | {
"id": "C0005612",
"name": "birthweight",
"pos": [
107,
118
]
} |
( gfr = ( 0.24 bw + 0.18 pa + 0.45 ) x weight ) , or from conceptional age ( ca ) ; | NA | {
"id": "C0005612",
"name": "bw",
"pos": [
15,
17
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
39,
45
]
} |
the biochemical , dermatological and neurological motor disorders of biotinidase deficiency ( multiple carboxylase deficiency ) show a dramatic response to pharmacological doses of biotin . | NA | {
"id": "C0220754",
"name": "of biotinidase",
"pos": [
66,
80
]
} | {
"id": "C0026755",
"name": "multiple carboxylase deficiency",
"pos": [
94,
125
]
} |
the hybrid gene appears to be expressed in a tissue-specific manner , since it is active in mouse lens cells but not in fibroblasts or in l cells . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
103,
108
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
120,
131
]
} |
as an initial step in the investigation of the structure , evolution and developmental regulation of the glycogen phosphorylase gene family , we have isolated partial cdnas to rat , rabbit and human muscle phosphorylase mrnas . | NA | {
"id": "C0917785",
"name": "glycogen phosphorylase",
"pos": [
105,
127
]
} | {
"id": "C0917783",
"name": "muscle phosphorylase",
"pos": [
199,
219
]
} |
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