text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
binding of polylysines to the lipid only occurred when three or more lysine residues were present per molecule . | NA | {
"id": "C0032518",
"name": "polylysines",
"pos": [
11,
22
]
} | {
"id": "C0024337",
"name": "lysine",
"pos": [
69,
75
]
} |
although the features of the mrna and the genes encoding p31 exhibit extensive similarity with those of ribosomal proteins , neither the identity nor the biological function of the protein has yet been determined . | NA | {
"id": "C0035552",
"name": "ribosomal proteins",
"pos": [
104,
122
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
181,
188
]
} |
the enzyme precipitated by the monoclonal antibodies remained fully active , whereas the enzyme precipitated by conventional antibodies was partly inactivated . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
31,
52
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
125,
135
]
} |
from the dependence of kinetic parameters of proenzyme catalysis on the effector dipeptide concentration , values of the equilibrium constants for binding of ile-val to the free trypsinogen , to the reversible zymogen-zargonp complex and to the proenzyme-zarg acyl intermediate have been obtained . | NA | {
"id": "C0041243",
"name": "trypsinogen",
"pos": [
178,
189
]
} | {
"id": "C0014436",
"name": "proenzyme",
"pos": [
245,
254
]
} |
magnesium-depleted 2- ( n-morpholino ) ethanesulfonate ( mes ) , glutamate , tubulin and microtubule-associated proteins were prepared and used to study the effects of exogenously added mgcl2 on tubulin-nucleotide interactions in 0.1 m mes with microtubule-associated proteins and in 1.0 m glutamate . | NA | {
"id": "C0024467",
"name": "magnesium",
"pos": [
0,
9
]
} | {
"id": "C0024472",
"name": "mgcl2",
"pos": [
186,
191
]
} |
one of these proteinases is a serine proteinase , since the processing is inhibited by phenylmethylsulfonyl fluoride , antipain , soybean trypsin inhibitor and diisopropylfluorophosphate , the other is a cathepsin d-like proteinase , since processing is also inhibited by pepstatin a . | NA | {
"id": "C0030940",
"name": "proteinases",
"pos": [
13,
24
]
} | {
"id": "C2717971",
"name": "serine proteinase",
"pos": [
30,
47
]
} |
one of these proteinases is a serine proteinase , since the processing is inhibited by phenylmethylsulfonyl fluoride , antipain , soybean trypsin inhibitor and diisopropylfluorophosphate , the other is a cathepsin d-like proteinase , since processing is also inhibited by pepstatin a . | NA | {
"id": "C0030940",
"name": "proteinases",
"pos": [
13,
24
]
} | {
"id": "C0030946",
"name": "proteinase",
"pos": [
221,
231
]
} |
the purified enzyme is stimulated by addition of phospholipids ( phosphatidylcholine , cardiolipin ) and proteins ( albumin , fatty acid-binding protein , lambda-globulin ) to the reaction mixture . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
105,
113
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
116,
123
]
} |
the purified enzyme is stimulated by addition of phospholipids ( phosphatidylcholine , cardiolipin ) and proteins ( albumin , fatty acid-binding protein , lambda-globulin ) to the reaction mixture . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
105,
113
]
} | {
"id": "C0017649",
"name": "globulin",
"pos": [
162,
170
]
} |
the metabolites of prostaglandin e that accumulated in the culture medium were purified by silicic acid column and silica gel thin-layer chromatographies , and analyzed by gas chromatography-mass spectrometry . | NA | {
"id": "C0037105",
"name": "silicic acid",
"pos": [
91,
103
]
} | {
"id": "C2936385",
"name": "silica gel",
"pos": [
115,
125
]
} |
to obtain comprehensive data on changes in collagen content and collagen synthesis during culture , total hydroxyproline was measured as well as [ 3h ] proline uptake and the formation of [ 3h ] hydroxyproline . | NA | {
"id": "C0033382",
"name": "proline",
"pos": [
113,
120
]
} | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
195,
209
]
} |
the phosphorylation of ribosomal protein s6 in fibroblasts , primary human tumour cells , established and sv40-transformed human cell lines was compared after the addition of 12-o-tetradecanoylphorbol 13-acetate ( tpa ) . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
47,
58
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
82,
87
]
} |
these findings indicated that the influence of tpa on the metabolic pathway , that finally leads to the phosphorylation of protein s6 in cells with a limited lifespan ( fibroblasts , primary human tumour cells ) can be mimicked by unknown steps also associated with immortalization ( establishment function ) and the tra... | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
169,
180
]
} | {
"id": "C0007634",
"name": "the",
"pos": [
338,
341
]
} |
in fibroblasts and primary tumour cells no changes in morphology were observed , even after 8h incubation . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
3,
14
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
34,
39
]
} |
arylsulfatase a ( arylsulfate sulfohydrolase , ec 3.1.6.1 ) , a mammalian lysosomal enzyme , is initially synthesized as a 69 , 67 and 64 kda precursor polypeptide in a prostate carcinoma cell line pc-3sf12 , in hela cells and in a normal human embryonic lung cell line wi-38 , respectively . | NA | {
"id": "C0007804",
"name": "arylsulfatase a",
"pos": [
0,
15
]
} | {
"id": "C0003940",
"name": "arylsulfate sulfohydrolase",
"pos": [
18,
44
]
} |
it is concluded that , as in the dna case , simultaneous hydration of nucleic bases the backbone of polynucleotides occurs at lower r.h. , and that the poly a-poly u hydration level is higher than poly a and poly u ones separately . | NA | {
"id": "C0032402",
"name": "poly",
"pos": [
100,
104
]
} | {
"id": "C0032400",
"name": "poly a",
"pos": [
197,
203
]
} |
normal iga analogous to human normal igg and secretory iga was shown to have horizontal orientation at air -- water interface . | NA | {
"id": "C0020835",
"name": "iga",
"pos": [
7,
10
]
} | {
"id": "C0020838",
"name": "secretory iga",
"pos": [
45,
58
]
} |
two types of overloading have been studied : primary iron overload due to an excessive intestinal iron absorption and secondary iron overload ( hemosiderosis ) produced in beta-thalassemia patients by hypertransfusional therapeutics . | NA | {
"id": "C0282193",
"name": "iron overload",
"pos": [
53,
66
]
} | {
"id": "C0019114",
"name": "hemosiderosis",
"pos": [
144,
157
]
} |
[ proteinases of small intestine enterocytes of swine . purification and properties of aspartyl proteinase similar to cathepsin d ] . | NA | {
"id": "C0030940",
"name": "proteinases",
"pos": [
2,
13
]
} | {
"id": "C2717969",
"name": "aspartyl proteinase",
"pos": [
87,
106
]
} |
rabbit antisera against a mixture of alpha'- and beta-subunits of chicken phosphorylase kinase yield a single precipitin line with this enzyme , do not show cross reactions of identity with the rabbit muscle enzyme but strongly inhibit the activity of the chicken enzyme and partially inhibit the activity of the rabbit ... | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
136,
142
]
} | {
"id": "C0022173",
"name": "isoenzyme",
"pos": [
327,
336
]
} |
when graded according to decreasing clearance , the sequence of the molecules was as follows : water = antipyrine greater than urea greater than p-aminohippuric acid greater than inulin greater than dextran 20 greater than dextran 70 . | NA | {
"id": "C0086140",
"name": "dextran",
"pos": [
199,
206
]
} | {
"id": "C0011795",
"name": "dextran 70",
"pos": [
223,
233
]
} |
because available evidence suggests that alterations in the serotonergic as well as dopaminergic tones underlie hallucinatory activity , we decided to investigate whether serotonin and dopamine pathways are modified in alcoholics with a history of hallucinosis . | NA | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
84,
96
]
} | {
"id": "C0013030",
"name": "dopamine",
"pos": [
185,
193
]
} |
the modulatory effect of opioids on dopaminergic functions has already been demonstrated in basic experiments : anatomical and biochemical data reveal an interaction between opioid receptors and dopamine ( da ) actions on dopaminergic nerve terminals , cell bodies , and afferent nerve endings . | NA | {
"id": "C0013030",
"name": "dopamine",
"pos": [
36,
44
]
} | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
222,
234
]
} |
in view of the low nickel content of the ss 2326 steel compared to conventional stainless steel , the material may possess potential for use as a dental or orthopaedic biomaterial . | NA | {
"id": "C0038239",
"name": "steel",
"pos": [
49,
54
]
} | {
"id": "C0038126",
"name": "stainless steel",
"pos": [
80,
95
]
} |
the high bladder toxicity of the alkylating oxazaphosphorine anticancer drugs , cyclophosphamide and ifosfamide is effectively reduced by the concomitant administration of mesna ( sodium 2-mercaptoethane sulphonate ) . | NA | {
"id": "C0010583",
"name": "cyclophosphamide",
"pos": [
80,
96
]
} | {
"id": "C0020823",
"name": "ifosfamide",
"pos": [
101,
111
]
} |
the conjugates extracted as the tetra-n-butylammonium salts are directly identified by their characteristic positive molecular ion adducts and fragment ions , and the corresponding abundant molecular anions . | NA | {
"id": "C0022023",
"name": "ion",
"pos": [
127,
130
]
} | {
"id": "C0003075",
"name": "anions",
"pos": [
200,
206
]
} |
mice with unmarked insulin deficiency preserved the tendency toward rhythmical changes in glucose release to blood , although muscle absorption of glucose was lowered . | NA | {
"id": "C0005802",
"name": "in glucose",
"pos": [
87,
97
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
147,
154
]
} |
fundamental signs of sepsis have been revealed : increased mortality ( up to 28 % in rats weighing 120-140 g ) from day 1 to day 45 after infection , development of local infectious foci , bacteremia , septicemia and septicopyemia . | NA | {
"id": "C0009450",
"name": "infection",
"pos": [
138,
147
]
} | {
"id": "C0016397",
"name": "of",
"pos": [
162,
164
]
} |
both malignant and normal cells were incubated in vitro with the phorbol ester 12-o-tetradecanoyl-phorbol-13-acetate ( tpa ) for 72 hours and the morphology , cytochemical profile , and surface markers were evaluated . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
65,
78
]
} | {
"id": "C0039654",
"name": "phorbol",
"pos": [
98,
105
]
} |
rosetted ( e+ ) lymphocytes ( t lymphocytes ) from nine patients in chronic phase and one patient in blast crisis were stimulated with t cell growth factor interleukin 2 ( il-2 ) and/or phytohemagglutinin ( pha ) . | NA | {
"id": "C0021758",
"name": "t cell",
"pos": [
135,
141
]
} | {
"id": "C0021764",
"name": "interleukin",
"pos": [
156,
167
]
} |
our goal was to determine whether beta globin mrna is significantly more stable than gamma globin mrna during the final stages of erythroid cell maturation . | NA | {
"id": "C0005221",
"name": "beta globin",
"pos": [
34,
45
]
} | {
"id": "C0017033",
"name": "gamma",
"pos": [
85,
90
]
} |
in conclusion , the failure of idazoxan to block the inhibitory effects of 6-fna , while exerting a potent competitive antagonism of clonidine-induced inhibitory effects , supports the proposal that alpha 2-adrenoceptors may in fact be subdivided into two subclasses , involving imidazoline and phenylethylamine recognit... | NA | {
"id": "C0009014",
"name": "clonidine",
"pos": [
133,
142
]
} | {
"id": "C1449836",
"name": "imidazoline",
"pos": [
279,
290
]
} |
the effects of galanin , a newly isolated neuropeptide , and of a galanin fragment ( galanin 1-10 ) were studied on various smooth muscle preparations in vitro . | NA | {
"id": "C0027895",
"name": "neuropeptide",
"pos": [
42,
54
]
} | {
"id": "C0060993",
"name": "galanin",
"pos": [
85,
92
]
} |
these sites have some characteristics of the low affinity binding sites of nifedipine and other related dihydropyridines . | NA | {
"id": "C0028066",
"name": "nifedipine",
"pos": [
75,
85
]
} | {
"id": "C0012315",
"name": "dihydropyridines",
"pos": [
104,
120
]
} |
the cardiovascular effects of doxazosin , a quinazoline derivative related to prasozin were investigated and compared to prazosin in the rabbit . | NA | {
"id": "C0114873",
"name": "doxazosin",
"pos": [
30,
39
]
} | {
"id": "C0032912",
"name": "prazosin",
"pos": [
121,
129
]
} |
the cardiovascular effects of doxazosin , a quinazoline derivative related to prasozin were investigated and compared to prazosin in the rabbit . | NA | {
"id": "C0034407",
"name": "quinazoline",
"pos": [
44,
55
]
} | {
"id": "C0032912",
"name": "prazosin",
"pos": [
121,
129
]
} |
radioligand binding studies using rabbit cerebral membranes showed that both doxazosin and prazosin were roughly equipotent at displacing [ 3h ] -prazosin from specific binding sites . | NA | {
"id": "C0114873",
"name": "doxazosin",
"pos": [
77,
86
]
} | {
"id": "C0032912",
"name": "prazosin",
"pos": [
146,
154
]
} |
however , the lower pa2 value for doxazosin at alpha 1-adrenoceptors in isolated thoracic aorta preparations suggests a lower potency compared to prazosin . | NA | {
"id": "C0114873",
"name": "doxazosin",
"pos": [
34,
43
]
} | {
"id": "C0032912",
"name": "prazosin",
"pos": [
146,
154
]
} |
there was a close agreement between alpha 1-adrenoceptor antagonist potency and maximum hypotensive effects with both doxazosin and prazosin . | NA | {
"id": "C0114873",
"name": "doxazosin",
"pos": [
118,
127
]
} | {
"id": "C0032912",
"name": "prazosin",
"pos": [
132,
140
]
} |
following pharmacological 'autonomic blockade ' and treatment with prazosin , doxazosin did not cause any further fall in blood pressure . | NA | {
"id": "C0032912",
"name": "prazosin",
"pos": [
67,
75
]
} | {
"id": "C0114873",
"name": "doxazosin",
"pos": [
78,
87
]
} |
these observations suggest that doxazosin , like prazosin , appears to exert its hypotensive action through alpha 1-adrenoceptor antagonism . | NA | {
"id": "C0114873",
"name": "doxazosin",
"pos": [
32,
41
]
} | {
"id": "C0032912",
"name": "prazosin",
"pos": [
49,
57
]
} |
the effects of chemical sympathectomy on dopamine , noradrenaline and adrenaline content in some peripheral tissues . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
52,
65
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
70,
80
]
} |
dopamine , noradrenaline ( na ) and adrenaline ( ad ) depletion by 6-hydroxydopamine ( 6-ohda ) and pargyline plus 6-ohda was investigated in the cat left ventricle , mesenteric and renal arteries , renal cortex , renal medulla and adrenal medulla . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
11,
24
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
36,
46
]
} |
the major products released from the cells from this lung with ionophore stimulation were 13-hydroxylinoleic acid greater than ltb4 greater than 5-hete greater than 12-hete greater than ltc4 greater than 15-hete greater than 11-hete approximately 9-hete . | NA | {
"id": "C0020349",
"name": "hete",
"pos": [
147,
151
]
} | {
"id": "C0044800",
"name": "12-hete",
"pos": [
165,
172
]
} |
6 these results suggest that d2 dopamine receptors are involved in mediating the excitatory neuronal response to dopamine in the cerebral cortex , whereas di dopamine receptors are unlikely to be involved . | NA | {
"id": "C0058698",
"name": "d2 dopamine receptors",
"pos": [
29,
50
]
} | {
"id": "C0034798",
"name": "dopamine receptors",
"pos": [
158,
176
]
} |
the reversal potential of this pharmacologically 'isolated ' hyperpolarizing response to gaba was estimated , from the current-voltage relationships , to be about -90 mv and was the same as that of the hyperpolarization induced by baclofen . | NA | {
"id": "C0016904",
"name": "gaba",
"pos": [
89,
93
]
} | {
"id": "C0004609",
"name": "baclofen",
"pos": [
231,
239
]
} |
these preliminary data suggest that alfacalcidol has appreciable antitumour activity in low grade non-hodgkin 's lymphomas . | NA | {
"id": "C0079747",
"name": "low grade",
"pos": [
88,
97
]
} | {
"id": "C0024305",
"name": "non-hodgkin 's",
"pos": [
98,
112
]
} |
administration of either naloxone or naltrexone to rats of the cr strain failed to attenuate the analgesic effect of these manipulations and in some cases even enhanced analgesia . | NA | {
"id": "C0027358",
"name": "naloxone",
"pos": [
25,
33
]
} | {
"id": "C0027360",
"name": "naltrexone",
"pos": [
37,
47
]
} |
antisera against all 3 classes of neuronal antigens contained antibodies that underwent retrograde axonal transport . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
0,
8
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
62,
72
]
} |
increasing concentrations of antibodies above the amount in whole antiserum did not increase the intensity of staining in retrogradely labeled neurons , suggesting saturation . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
29,
39
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
66,
75
]
} |
during precipitated mor withdrawal , a decline in norepinephrine ( ne ) concentrations was preceded by an increase in the level of its metabolite normetanephrine ( nme ) in the medial basal hypothalamus ( mbh ) as well as the preoptic area-anterior hypothalamus ( poa-ah ) . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
50,
64
]
} | {
"id": "C0028385",
"name": "normetanephrine",
"pos": [
146,
161
]
} |
the activity of all identified sfo neurons was excited by microiontophoretically ( miph ) applied angiotensin ii ( aii ) and the effect of aii was blocked by miph-applied saralasin ( sar ) , an aii antagonist , but not by atropine ( atr ) , a muscarinic antagonist . | NA | {
"id": "C0036193",
"name": "saralasin",
"pos": [
171,
180
]
} | {
"id": "C0003009",
"name": "aii",
"pos": [
194,
197
]
} |
the binding sites were specific for kinins and kinin analogues , and the order of potency in competing for [ 125i ] tyr-bradykinin binding was lys-bradykinin greater than bradykinin greater than tyr-bradykinin greater than tyr8-bradykinin much much greater than des-arg9-bradykinin . | NA | {
"id": "C0022714",
"name": "kinins",
"pos": [
36,
42
]
} | {
"id": "C0006100",
"name": "bradykinin",
"pos": [
271,
281
]
} |
the binding sites were specific for kinins and kinin analogues , and the order of potency in competing for [ 125i ] tyr-bradykinin binding was lys-bradykinin greater than bradykinin greater than tyr-bradykinin greater than tyr8-bradykinin much much greater than des-arg9-bradykinin . | NA | {
"id": "C0022474",
"name": "lys-bradykinin",
"pos": [
143,
157
]
} | {
"id": "C0006100",
"name": "bradykinin",
"pos": [
271,
281
]
} |
although nile glycoproteins and the neural cell adhesion molecule ( n-cam ) both appear to be involved in neurite fasciculation , nile and n-cam components can be shown to be different from each other by several criteria . | NA | {
"id": "C0950625",
"name": "nile glycoproteins",
"pos": [
9,
27
]
} | {
"id": "C0282587",
"name": "n-cam",
"pos": [
139,
144
]
} |
direct projection from cortex area v1 to v4 in the rhesus monkey was demonstrated by means of retrograde axonal transport of wheat germ agglutinin-conjugated horseradish peroxidase ( wga-hrp ) . | NA | {
"id": "C0019941",
"name": "horseradish peroxidase",
"pos": [
158,
180
]
} | {
"id": "C0078473",
"name": "wga-hrp",
"pos": [
183,
190
]
} |
the localization and characterization of receptors for somatostatin-14 ( s-14 ) and somatostatin-28 ( s-28 ) were studied in the rat brain using the iodinated agonists [ tyr0 , d-trp8 ] s-14 and [ leu8 , d-trp22 , tyr25 ] s-28 as tracers . | NA | {
"id": "C0037659",
"name": "s-14",
"pos": [
73,
77
]
} | {
"id": "C0074854",
"name": "s-28",
"pos": [
222,
226
]
} |
specificity studies demonstrated that either tracer could be displaced with s-28 , s-14 or their agonists . | NA | {
"id": "C0074854",
"name": "s-28",
"pos": [
76,
80
]
} | {
"id": "C0037659",
"name": "s-14",
"pos": [
83,
87
]
} |
scatchard analysis of saturation curves gave a one-site interaction with kd values of 0.42 +/- 0.09 nm and 0.32 +/- 0.04 nm for the s-14 and s-28 iodinated agonists , respectively . | NA | {
"id": "C0037659",
"name": "s-14",
"pos": [
132,
136
]
} | {
"id": "C0074854",
"name": "s-28",
"pos": [
141,
145
]
} |
by radioautography , the distribution of receptors for both s-14 and s-28 appeared very similar with high levels of binding in the deep layers of the cortex , the cingulate cortex , the claustrum , the locus coeruleus and most structures of the limbic system . | NA | {
"id": "C0037659",
"name": "s-14",
"pos": [
60,
64
]
} | {
"id": "C0074854",
"name": "s-28",
"pos": [
69,
73
]
} |
the effects upon icp of the intravenous administration of urea , mannitol , acetazolamide , dimethyl sulfoxide , norepinephrine , epinephrine , isoproterenol , nitroglycerin , papaverine , histamine , angiotension ii , pitressin , sodium nitroprusside , diazoxide , lidocaine , sodium pentobarbitone , as well as inhalat... | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
113,
127
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
130,
141
]
} |
although potent inhibitors of nucleoside transport inhibited araa uptake marginally , adenosine competed with araa for about 50 % of the uptake capacity . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
86,
95
]
} | {
"id": "C0042646",
"name": "araa",
"pos": [
110,
114
]
} |
this value was similar to those obtained previously for r-pia and adenosine itself and suggests that these nucleosides may be interacting with the same receptor site on myenteric nerve endings . | NA | {
"id": "C0031484",
"name": "r-pia",
"pos": [
56,
61
]
} | {
"id": "C0001443",
"name": "adenosine",
"pos": [
66,
75
]
} |
plasma concentrations of norepinephrine ( ne ) , epinephrine ( e ) , dopamine ( da ) , and glucose ( gl ) were determined in various vascular regions . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
25,
39
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
49,
60
]
} |
in the united states more than 250 cases of sulfite-related adverse reactions , including anaphylactic shock , asthmatic attacks , urticaria and angioedema , nausea , abdominal pain and diarrhea , seizures and death , have been reported , including 6 deaths allegedly associated with restaurant food containing sulfites ... | NA | {
"id": "C0042109",
"name": "urticaria",
"pos": [
131,
140
]
} | {
"id": "C0002994",
"name": "angioedema",
"pos": [
145,
155
]
} |
the efficacy of free amphotericin b ( ampb ) and liposomal-amphotericin b ( l-ampb ) in the protection against c. albicans infection in mice was studied . | NA | {
"id": "C1145701",
"name": "liposomal-amphotericin b",
"pos": [
49,
73
]
} | {
"id": "C0002679",
"name": "ampb",
"pos": [
78,
82
]
} |
intrathoracic involvement with cutaneous t-cell lymphoma ( ctcl ) was documented in eight patients with mycosis fungoides and two patients with sezary syndrome . | NA | {
"id": "C0079773",
"name": "cutaneous t-cell lymphoma",
"pos": [
31,
56
]
} | {
"id": "C0036920",
"name": "sezary syndrome",
"pos": [
144,
159
]
} |
the case histories of 1961 patients with inflammatory bowel disease ( ibd ) , 1227 with crohn 's disease ( cd ) and 734 with ulcerative colitis ( uc ) , have been studied for the incidence of extraintestinal malignant neoplasms . | NA | {
"id": "C0021390",
"name": "inflammatory bowel disease",
"pos": [
41,
67
]
} | {
"id": "C0010346",
"name": "crohn 's disease",
"pos": [
88,
104
]
} |
at the time of chromosome analysis , 5 patients had a history of myelofibrosis or agnogenic myeloid metaplasia , 2 had acute nonlymphocytic leukemia , 2 had a myelodysplastic syndrome , one had polycythemia vera , one had sideroblastic anemia , one had acute lymphocytic leukemia , and one had an undifferentiated myelop... | NA | {
"id": "C0001815",
"name": "agnogenic myeloid metaplasia",
"pos": [
82,
110
]
} | {
"id": "C0027022",
"name": "myeloproliferative disorder",
"pos": [
314,
341
]
} |
the ingestion of high levels of fats , especially unsaturated fats , has been shown to enhance carcinogenesis in a variety of experimental model systems . | NA | {
"id": "C0015677",
"name": "fats",
"pos": [
32,
36
]
} | {
"id": "C0015678",
"name": "unsaturated fats",
"pos": [
50,
66
]
} |
in contrast to fluorinated pyrimidines in current use , f3methyl-dcyd + h4urd potentially allows an exclusive dna- , rather than both a dna- and rna- , directed approach . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
110,
113
]
} | {
"id": "C0000702",
"name": "a dna",
"pos": [
134,
139
]
} |
biochemical analyses of h-4 cells demonstrated that selenium treatment caused a significant dose-dependent increase in oxidized and reduced glutathione ( gssg and gsh ) as well as in the gssg : gsh ratio as was previously observed in liver in vivo . | NA | {
"id": "C0061516",
"name": "gssg",
"pos": [
154,
158
]
} | {
"id": "C0017817",
"name": "gsh",
"pos": [
194,
197
]
} |
after incubation of the hct-8r cells with d- [ 1,6-3h ] glucosamine and l- [ 1-14c ] fucose , strong acid hydrolysis of the labeled glycopeptide fraction excluded from bio-gel p-6 produced 3h-labeled n-acetylglucosamine and n-acetylgalactosamine . | NA | {
"id": "C0017718",
"name": "glucosamine",
"pos": [
56,
67
]
} | {
"id": "C0001056",
"name": "acetylglucosamine",
"pos": [
202,
219
]
} |
prothrombinase is a complex in which the proteinase , factor xa , a cofactor , factor va , and calcium are bound to a membrane surface to generate the active enzyme . | NA | {
"id": "C0015518",
"name": "prothrombinase",
"pos": [
0,
14
]
} | {
"id": "C0015520",
"name": "factor xa",
"pos": [
54,
63
]
} |
each of these anthrapyrazoles were significantly more active than were the other synthetic intercalating agents , the anthracenediones mitoxantrone and ametantrone , against the tumors of the expanded panel . | NA | {
"id": "C0003174",
"name": "anthracenediones",
"pos": [
118,
134
]
} | {
"id": "C0026259",
"name": "mitoxantrone",
"pos": [
135,
147
]
} |
effects of uridine and thymidine on the degradation of 5-fluorouracil , uracil , and thymine by rat liver dihydropyrimidine dehydrogenase . | NA | {
"id": "C0016360",
"name": "fluorouracil",
"pos": [
57,
69
]
} | {
"id": "C0041917",
"name": "uracil",
"pos": [
72,
78
]
} |
effects of uridine and thymidine on the degradation of 5-fluorouracil , uracil , and thymine by rat liver dihydropyrimidine dehydrogenase . | NA | {
"id": "C0041917",
"name": "uracil",
"pos": [
63,
69
]
} | {
"id": "C0040087",
"name": "thymine",
"pos": [
85,
92
]
} |
the kinetic properties and control mechanisms of 5-fluorouracil ( 5-fu ) , uracil , and thymine degradation by rat liver dihydropyrimidine dehydrogenase were studied in vitro . | NA | {
"id": "C0016360",
"name": "5-fu",
"pos": [
66,
70
]
} | {
"id": "C0041917",
"name": "uracil",
"pos": [
75,
81
]
} |
the calculated michaelis constant ( km ) for 5-fu was 3.49 +/- 0.41 ( se ) microm , similar to those for uracil ( 2.26 +/- 0.28 microm ) and for thymine ( 2.23 +/- 0.34 microm ) . | NA | {
"id": "C0016360",
"name": "5-fu",
"pos": [
45,
49
]
} | {
"id": "C0041917",
"name": "uracil",
"pos": [
105,
111
]
} |
the calculated michaelis constant ( km ) for 5-fu was 3.49 +/- 0.41 ( se ) microm , similar to those for uracil ( 2.26 +/- 0.28 microm ) and for thymine ( 2.23 +/- 0.34 microm ) . | NA | {
"id": "C0041917",
"name": "uracil",
"pos": [
105,
111
]
} | {
"id": "C0040087",
"name": "thymine",
"pos": [
145,
152
]
} |
the specific activities of dihydropyrimidine dehydrogenase ( nmol/min/mg of protein ) for 5-fu , uracil , and thymine were 0.82 , 0.68 , and 0.56 , respectively . | NA | {
"id": "C0016360",
"name": "5-fu",
"pos": [
90,
94
]
} | {
"id": "C0041917",
"name": "uracil",
"pos": [
97,
103
]
} |
the specific activities of dihydropyrimidine dehydrogenase ( nmol/min/mg of protein ) for 5-fu , uracil , and thymine were 0.82 , 0.68 , and 0.56 , respectively . | NA | {
"id": "C0041917",
"name": "uracil",
"pos": [
97,
103
]
} | {
"id": "C0040087",
"name": "thymine",
"pos": [
110,
117
]
} |
the results demonstrate clearly that ndmad , which is effectively catalyzed by a specific p-450 isozyme inducible by compounds such as ethanol , acetone , and isopropanol , is primarily responsible for the activation of ndma to a mutagen . | NA | {
"id": "C0001962",
"name": "ethanol",
"pos": [
135,
142
]
} | {
"id": "C0022237",
"name": "isopropanol",
"pos": [
159,
170
]
} |
thus despite antigenic heterogeneity , sufficient similarity remains between different melanomas to permit specific immunotherapy to be targeted to a limited number of tumor antigens . | NA | {
"id": "C0003320",
"name": "antigenic",
"pos": [
13,
22
]
} | {
"id": "C0003335",
"name": "tumor antigens",
"pos": [
168,
182
]
} |
it also had a ganglioside pattern similar to that of normal melanocytes but not melanomas , i.e. , a high gm3 ganglioside content compared to the amounts of gm2 , gd2 , and gd3 gangliosides . | NA | {
"id": "C0017082",
"name": "ganglioside",
"pos": [
14,
25
]
} | {
"id": "C0016897",
"name": "gm3 ganglioside",
"pos": [
106,
121
]
} |
stereological analysis of the fibroblasts showed that their absolute number had doubled and that the cell volume of the individual fibroblast had increased markedly . | NA | {
"id": "C0007634",
"name": "the cell",
"pos": [
97,
105
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
131,
141
]
} |
this anti-cea mab-dtpa-111in preparation was stable , retained immunological activity , did not require column chromatography to remove unbound 111in , was specific for a cea-bearing tumor , and was effective for tumor imaging over a wide range of antibody doses ( 3 to 300 micrograms mab/kg body weight ) . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
248,
256
]
} | {
"id": "C0003250",
"name": "mab",
"pos": [
285,
288
]
} |
all of the 42 adenocarcinomas and 18 carcinoids were strongly immunoreactive either diffusely or focally . | NA | {
"id": "C0001418",
"name": "adenocarcinomas",
"pos": [
14,
29
]
} | {
"id": "C0007095",
"name": "carcinoids",
"pos": [
37,
47
]
} |
the antibodies b6.2 and b72.3 , which reacted against human breast ( clouser ) and colon ( ls174t ) tumor cells in vitro and in vivo , respectively , and the isotype matched anti-horseradish peroxidase antibody which did not bind to these tumors were used in pharmacokinetic and imaging experiments . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
4,
14
]
} | {
"id": "C0021017",
"name": "isotype",
"pos": [
158,
165
]
} |
these observations will be useful in the further investigation of pathophysiology of tumor-induced leukemoid reactions , hypercalcemia , and other paraneoplastic syndromes . | NA | {
"id": "C0027651",
"name": "tumor",
"pos": [
85,
90
]
} | {
"id": "C0030472",
"name": "paraneoplastic syndromes",
"pos": [
147,
171
]
} |
the cytochrome p-450 monooxygenase system of rabbit bladder mucosa : enzyme components and isozyme 5-dependent metabolism of 2-aminofluorene . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
69,
75
]
} | {
"id": "C0022173",
"name": "isozyme",
"pos": [
91,
98
]
} |
the effect of bound sulfate groups and uronic acid residues of glycosaminoglycans on their behavior in chromatography on hydrophobic gel was examined by the use of several pairs of depolymerized chondroitin , chondroitin 4- or 6-sulfate , and dermatan sulfate having comparable degree of polymerization . | NA | {
"id": "C0017973",
"name": "glycosaminoglycans",
"pos": [
63,
81
]
} | {
"id": "C0008454",
"name": "chondroitin",
"pos": [
209,
220
]
} |
the effect of bound sulfate groups and uronic acid residues of glycosaminoglycans on their behavior in chromatography on hydrophobic gel was examined by the use of several pairs of depolymerized chondroitin , chondroitin 4- or 6-sulfate , and dermatan sulfate having comparable degree of polymerization . | NA | {
"id": "C0008454",
"name": "chondroitin",
"pos": [
195,
206
]
} | {
"id": "C0011602",
"name": "dermatan sulfate",
"pos": [
243,
259
]
} |
chromatography on phenyl-sepharose cl-4b in 4.0-2.0 m ammonium sulfate containing 10mm hydrochloric acid showed that : the retention of depolymerized chondroitin 4- or 6-sulfate on the gel varies with the temperature , whereas the depolymerized samples of chondroitin and dermatan sulfate does not show a temperature dep... | NA | {
"id": "C0002620",
"name": "ammonium",
"pos": [
54,
62
]
} | {
"id": "C0038720",
"name": "sulfate",
"pos": [
281,
288
]
} |
chromatography on phenyl-sepharose cl-4b in 4.0-2.0 m ammonium sulfate containing 10mm hydrochloric acid showed that : the retention of depolymerized chondroitin 4- or 6-sulfate on the gel varies with the temperature , whereas the depolymerized samples of chondroitin and dermatan sulfate does not show a temperature dep... | NA | {
"id": "C0008454",
"name": "chondroitin",
"pos": [
150,
161
]
} | {
"id": "C0011602",
"name": "dermatan",
"pos": [
272,
280
]
} |
mitoxantrone is a new anthracenedione derivative that suppresses cell proliferation in the t-47d human breast tumor cell line as revealed by colony-forming assay in soft agar and growth study in monolayer culture . | NA | {
"id": "C0026259",
"name": "mitoxantrone",
"pos": [
0,
12
]
} | {
"id": "C0003174",
"name": "anthracenedione",
"pos": [
22,
37
]
} |
macrocreatine kinase type 2 in the serum of patients with tumors and with nonmalignant colonic diseases . | NA | {
"id": "C0027651",
"name": "tumors",
"pos": [
58,
64
]
} | {
"id": "C0032927",
"name": "nonmalignant",
"pos": [
74,
86
]
} |
the separate measurement of the catecholamines adrenaline and noradrenaline and their metabolites metanephrine and normetanephrine in urine or serum are the most sensitive screening tests . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
47,
57
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
62,
75
]
} |
the separate measurement of the catecholamines adrenaline and noradrenaline and their metabolites metanephrine and normetanephrine in urine or serum are the most sensitive screening tests . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
47,
57
]
} | {
"id": "C0025562",
"name": "metanephrine",
"pos": [
118,
130
]
} |
the separate measurement of the catecholamines adrenaline and noradrenaline and their metabolites metanephrine and normetanephrine in urine or serum are the most sensitive screening tests . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
62,
75
]
} | {
"id": "C0028385",
"name": "normetanephrine",
"pos": [
115,
130
]
} |
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