text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
four isomeric monophosphates and five isomeric bisphosphates of riboflavin were isolated from commercial fmn or were prepared by acid-catalyzed isomerization . | NA | {
"id": "C0035527",
"name": "riboflavin",
"pos": [
64,
74
]
} | {
"id": "C0016388",
"name": "fmn",
"pos": [
105,
108
]
} |
among the flavoproteins thus far studied by nmr techniques , old yellow enzyme is the only protein that shows a conformation of the reduced prosthetic group with the n ( 5 ) atom lifted out of the molecular plane . | NA | {
"id": "C0016223",
"name": "flavoproteins",
"pos": [
10,
23
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
91,
98
]
} |
weakly basic amines inhibit the proteolytic conversion of proalbumin to serum albumin in cultured rat hepatocytes . | NA | {
"id": "C0032923",
"name": "proalbumin",
"pos": [
58,
68
]
} | {
"id": "C0036773",
"name": "serum",
"pos": [
72,
77
]
} |
effects of weak amines on the proteolytic conversion of proalbumin to serum albumin were studied in primary culture of rat hepatocytes . | NA | {
"id": "C0032923",
"name": "proalbumin",
"pos": [
56,
66
]
} | {
"id": "C0036773",
"name": "serum",
"pos": [
70,
75
]
} |
however , in the presence of chloroquine the conversion to serum albumin was inhibited and proalbumin per se was released into medium . | NA | {
"id": "C0036773",
"name": "serum albumin",
"pos": [
59,
72
]
} | {
"id": "C0032923",
"name": "proalbumin",
"pos": [
91,
101
]
} |
acyltransferase activity was measured by the formation of [ 14c ] cholesteryl ester from [ 14c ] cholesterol using purified enzyme . | NA | {
"id": "C0008387",
"name": "cholesteryl ester",
"pos": [
66,
83
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
97,
108
]
} |
during the 55 months of follow-up after the physical training or the equivalent spontaneous activity , we observed the prevalence of risk factors and of cardiac events such as angina , new mi , unstable angina , coronary bypass grafting and cardiac death . | NA | {
"id": "C0002962",
"name": "angina",
"pos": [
176,
182
]
} | {
"id": "C0002965",
"name": "unstable angina",
"pos": [
194,
209
]
} |
a 25-year-old man with narcolepsy and cataplexy experienced partial relief of symptomatology following administration of methylphenidate . | NA | {
"id": "C0027404",
"name": "narcolepsy",
"pos": [
23,
33
]
} | {
"id": "C0007384",
"name": "cataplexy",
"pos": [
38,
47
]
} |
the main neurotransmitter involved is noradrenaline but recent interest has focused on several laterally situated nuclei which are capable of synthesizing adrenaline . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
38,
51
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
155,
165
]
} |
supine and upright plasma renin activity , plasma aldosterone , norepinephrine , epinephrine and dopamine levels , urinary catecholamine excretion rates as well as serum prolactin , low and high density cholesterol and triglyceride concentrations were not changed after cianergoline or placebo . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
64,
78
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
81,
92
]
} |
enalaprilic acid ( mk 422 ) , the active metabolite of enalapril , has recently become available for intravenous administration . | NA | {
"id": "C0014027",
"name": "enalaprilic acid",
"pos": [
0,
16
]
} | {
"id": "C0014025",
"name": "enalapril",
"pos": [
55,
64
]
} |
using 125i-labeled c1 and a rat monoclonal antibody specific for the class i antigen , it has been found that the rate of activation is primarily dependent on antibody density on the cell surface and not on antigen or c1 density . | NA | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
32,
51
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
159,
167
]
} |
modulation of complement receptors of a human monocyte cell line , u-937 , during incubation with phorbol myristate acetate : expression of an ic3b-specific receptor ( cr3 ) . | NA | {
"id": "C0034793",
"name": "complement receptors",
"pos": [
14,
34
]
} | {
"id": "C0079785",
"name": "cr3",
"pos": [
168,
171
]
} |
with affinity-purified antibody fractions eluted from individual antigen bands on nitrocellulose blots it is shown that the anti-sm-reactive polypeptides b/b ' and d contain common epitopes . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
65,
72
]
} | {
"id": "C0003316",
"name": "epitopes",
"pos": [
181,
189
]
} |
we also report the finding of one human anti-sm serum with exclusive specificity for the b/b ' doublet and a mouse monoclonal anti-sm antibody recognizing only the d protein , indicating that these antigens also carry unique epitopes . | NA | {
"id": "C0003320",
"name": "antigens",
"pos": [
198,
206
]
} | {
"id": "C0003316",
"name": "epitopes",
"pos": [
225,
233
]
} |
these data suggest that each of the amphetamines may inhibit tph activity , whereas only meth and pca produced long-lasting decreases in indoleamine concentrations , reflecting either varying degrees of toxicity or differential effects of amp on enzyme activity and neurotransmitter concentrations . | NA | {
"id": "C0002667",
"name": "amphetamines",
"pos": [
36,
48
]
} | {
"id": "C0030131",
"name": "pca",
"pos": [
98,
101
]
} |
these data suggest that each of the amphetamines may inhibit tph activity , whereas only meth and pca produced long-lasting decreases in indoleamine concentrations , reflecting either varying degrees of toxicity or differential effects of amp on enzyme activity and neurotransmitter concentrations . | NA | {
"id": "C0002667",
"name": "amphetamines",
"pos": [
36,
48
]
} | {
"id": "C0002658",
"name": "amp",
"pos": [
239,
242
]
} |
rings of rat vas deferens and caudal artery were incubated with [ 3h ] inositol in krebs-ringer bicarbonate buffer containing 10 mm lithium chloride , and the production of water-soluble [ 3h ] inositol phosphates was monitored . | NA | {
"id": "C0021547",
"name": "inositol",
"pos": [
71,
79
]
} | {
"id": "C0021554",
"name": "inositol phosphates",
"pos": [
194,
213
]
} |
epinephrine , phenylephrine and methoxamine were as effective as norepinephrine , suggesting that these drugs are full agonists in causing this response . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
0,
11
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
65,
79
]
} |
when chronically infarcted hearts were subjected to programmed electrical stimulation , 1 mg/kg of clofilium inhibited the re-induction of either ventricular tachycardia or ventricular fibrillation in 5 of 6 animals and slowed the rate of the induced tachycardia in the sixth . | NA | {
"id": "C0042514",
"name": "ventricular tachycardia",
"pos": [
146,
169
]
} | {
"id": "C0039231",
"name": "tachycardia",
"pos": [
251,
262
]
} |
six steroid tests based on urinary free cortisol and plasma total cortisol were used for differentiating between 27 patients with cushing 's syndrome in whom the diagnosis was confirmed by operation or autopsy and 25 obese subjects imitating this syndrome in whom hypercortisolism was excluded by repeated examinations p... | NA | {
"id": "C0010481",
"name": "cushing 's syndrome",
"pos": [
130,
149
]
} | {
"id": "C0001622",
"name": "hypercortisolism",
"pos": [
264,
280
]
} |
the nuclear association of this protein is sensitive to dnase treatment of the cells and quantitative electron microscopy confirms that the ldh-ssb protein is located close to chromatin structures . | NA | {
"id": "C0028589",
"name": "nuclear",
"pos": [
4,
11
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
148,
155
]
} |
we have approached the study of the ability of different types of lesions produced by dna-damaging agents to develop sister-chromatid exchanges ( sces ) by analyzing sce levels observed in allium cepa l cells with brdu-substituted dna and exposed to visible light ( vl ) , an irradiation which produces uracil residues i... | NA | {
"id": "C0041917",
"name": "uracil",
"pos": [
303,
309
]
} | {
"id": "C0006242",
"name": "bromouracil",
"pos": [
349,
360
]
} |
cultured cells ( drosophila kc cells , gliosarcoma 9l , human fibroblasts and mouse spleen lymphocytes ) exhibit variations of nad-glycohydrolase and poly ( adp-ribose ) polymerase activities and the assessment of poly ( adp-ribose ) polymerase activity in permeabilized cells requires simultaneous assay of nad-glycohyd... | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
62,
73
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
271,
276
]
} |
estrogens have long been known to influence lipid and lipoprotein levels by decreasing ldl ( the atherogenic lipoprotein ) and by increasing hdl ( the protective lipoprotein ) . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
44,
49
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
162,
173
]
} |
results of experiments with human plasma albumin found to be greater than 98 % pure by one- and two-dimensional gel electrophoresis and delipidated albumin indicate that an albumin source is needed for burst formation to occur . | NA | {
"id": "C0304925",
"name": "human",
"pos": [
28,
33
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
173,
180
]
} |
a multiparameter cell separative procedure is described that enables normal transplantable hemopoietic stem cells that preferentially home to the marrow of lethally irradiated mice to be enriched and separated from the majority of spleen colony-forming cells that are assayed 13 days after transplantation ( cfu-s13 ) . | NA | {
"id": "C0018956",
"name": "hemopoietic stem cells",
"pos": [
91,
113
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
253,
258
]
} |
between 20 % and 30 % of transplantable hemopoietic stem cells has been recovered in approximately 1 % of total nucleated cells from the starting preparation , and enrichments of 25- to 30-fold have been achieved permitting hemopoietic reconstitution of lethally irradiated host mice with as few as 400 donor cells . | NA | {
"id": "C0018956",
"name": "hemopoietic stem cells",
"pos": [
40,
62
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
309,
314
]
} |
exercise-induced asthma ( eia ) was recorded in 20 of 22 asthmatic children who cycled for 8 min while inspiring hot ( 32-40 degrees c ) dry ( 3-10 mg h2o l-1 ) air . | NA | {
"id": "C0004099",
"name": "exercise-induced asthma",
"pos": [
0,
23
]
} | {
"id": "C0004096",
"name": "asthmatic",
"pos": [
57,
66
]
} |
we have studied 23 asthmatic children who were wheezy when attending a hospital clinic or following tests for exercise-induced asthma . | NA | {
"id": "C0004096",
"name": "asthmatic",
"pos": [
19,
28
]
} | {
"id": "C0004099",
"name": "exercise-induced asthma",
"pos": [
110,
133
]
} |
experiments in which the extracellular concentration of chloride was reduced indicated that only an early component of the inhibition was due to a conductance for that anion . | NA | {
"id": "C0008203",
"name": "chloride",
"pos": [
56,
64
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
168,
173
]
} |
concomitant determination of plasma concentrations of diazepam and its major metabolite , desmethyldiazepam , showed that diazepam increased during the 2 weeks of treatment , suggesting that the observed tolerance was not metabolic but functional in nature . | NA | {
"id": "C0011279",
"name": "desmethyldiazepam",
"pos": [
90,
107
]
} | {
"id": "C0012010",
"name": "diazepam",
"pos": [
122,
130
]
} |
the phorbol ester , 12-o-tetradecanoylphorbol 13-acetate ( tpa ) , had no effects on insulin secretion in the absence of ca2+ . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
4,
17
]
} | {
"id": "C0039654",
"name": "12-o-tetradecanoylphorbol 13-acetate",
"pos": [
20,
56
]
} |
dna complementary to the rat hypothalamic mrna coding for the corticotropin-releasing factor precursor ( prepro-crf ) has been cloned by screening a cdna library with a human genomic dna probe . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
0,
3
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
185,
186
]
} |
after 48 h culture , the total glutathione level decreased and the oxidized glutathione level increased in the two types of unstimulated and stimulated cells . | NA | {
"id": "C0017817",
"name": "glutathione",
"pos": [
31,
42
]
} | {
"id": "C0061516",
"name": "oxidized glutathione",
"pos": [
67,
87
]
} |
the enhancement of the gssg/gsh + gssg ratio , irrespective of culture conditions , indicates a severely disturbed redox state of the cells . | NA | {
"id": "C0061516",
"name": "gssg",
"pos": [
23,
27
]
} | {
"id": "C0017817",
"name": "gsh",
"pos": [
28,
31
]
} |
in contrast with carboxypeptidases a that strongly bind to their corresponding severed activation segments , no interaction was observed between carboxypeptidase b and its severed activation segment . | NA | {
"id": "C0007075",
"name": "carboxypeptidases",
"pos": [
17,
34
]
} | {
"id": "C0054756",
"name": "carboxypeptidase b",
"pos": [
145,
163
]
} |
the kinetic behaviour of the atpase activity of beef heart f1 depends largely on the exposure of the enzyme to some anionic ligands such as sulphate and/or edta . | NA | {
"id": "C0003075",
"name": "anionic",
"pos": [
116,
123
]
} | {
"id": "C0038720",
"name": "sulphate",
"pos": [
140,
148
]
} |
the long t2 relaxation value observed for neutral lipid methylenes in metastatic cancer cells ( greater than 300 ms ) was not observed for any of the 4 lipoproteins studied . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
50,
55
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
152,
164
]
} |
the data suggest that activated protein kinase c interferes with gtp- and hormone-induced adenylate cyclase inhibition probably by phosphorylating the inhibitory guanine nucleotide-binding regulatory component ni . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
65,
68
]
} | {
"id": "C0018328",
"name": "guanine nucleotide",
"pos": [
162,
180
]
} |
the new pbp from all strains that have been examined has an identical mobility on sds gel electrophoresis and is the only pbp still present in an uncomplexed state with beta-lactams ( and therefore the only functional pbp when these strains are grown in media containing concentrations of beta-lactam antibiotics suffici... | NA | {
"id": "C0282215",
"name": "beta-lactams",
"pos": [
169,
181
]
} | {
"id": "C0026458",
"name": "beta-lactam antibiotics",
"pos": [
289,
312
]
} |
gastrointestinal hormones , including gastrin , cholecystokinin , secretin , somatostatin , and others , are released by contact of chyme with the intestinal mucosa , and affect contractions of the proximal stomach , distal stomach , and duodenum . | NA | {
"id": "C0017182",
"name": "gastrointestinal",
"pos": [
0,
16
]
} | {
"id": "C0017151",
"name": "gastrin",
"pos": [
38,
45
]
} |
gastrointestinal hormones , including gastrin , cholecystokinin , secretin , somatostatin , and others , are released by contact of chyme with the intestinal mucosa , and affect contractions of the proximal stomach , distal stomach , and duodenum . | NA | {
"id": "C0017182",
"name": "gastrointestinal",
"pos": [
0,
16
]
} | {
"id": "C0008328",
"name": "cholecystokinin",
"pos": [
48,
63
]
} |
gastrointestinal hormones , including gastrin , cholecystokinin , secretin , somatostatin , and others , are released by contact of chyme with the intestinal mucosa , and affect contractions of the proximal stomach , distal stomach , and duodenum . | NA | {
"id": "C0017182",
"name": "gastrointestinal",
"pos": [
0,
16
]
} | {
"id": "C0036534",
"name": "secretin",
"pos": [
66,
74
]
} |
an analysis of representative members of protease families , notably the mammalian serine proteases , suggests that they are the products of processes of recombination of gene segments that give rise to functionally and structurally distinct domains . | NA | {
"id": "C0030946",
"name": "protease",
"pos": [
41,
49
]
} | {
"id": "C0036734",
"name": "serine proteases",
"pos": [
83,
99
]
} |
the immunobead test was used to study the immunoglobulin class of antibodies on sperm before and after penetration through a microcolumn of cervical mucus . | NA | {
"id": "C0021017",
"name": "immunoglobulin class",
"pos": [
42,
62
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
66,
76
]
} |
these lectins form glycoconjugates by binding to l-fucose ( ue ) , n-acetylglucosamine and sialic acid ( wga ) , and d-galactose and d-galactose- ( 1-3 ) -d-n-acetylgalactosamine ( pa ) , sugars that are present in the carbohydrate side chains of the mucus glycoproteins ( mucins ) . | NA | {
"id": "C0017906",
"name": "glycoconjugates",
"pos": [
19,
34
]
} | {
"id": "C0007004",
"name": "carbohydrate",
"pos": [
219,
231
]
} |
in rat with constant i. v. infusion of 40 % glucose solution , administration of insulin ( 0.9-1.0 unit/100 g ) reduced considerably diuresis , filtration and excretion of glucose in urine , the glucose content in the blood remaining the same . | NA | {
"id": "C0773370",
"name": "infusion",
"pos": [
27,
35
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
195,
202
]
} |
in rat with constant i. v. infusion of 40 % glucose solution , administration of insulin ( 0.9-1.0 unit/100 g ) reduced considerably diuresis , filtration and excretion of glucose in urine , the glucose content in the blood remaining the same . | NA | {
"id": "C0017725",
"name": "glucose",
"pos": [
44,
51
]
} | {
"id": "C0005802",
"name": "glucose",
"pos": [
195,
202
]
} |
several authors have reported that metoclopramide ( mcp ) , a dopaminergic antagonist , stimulates aldosterone secretion and that dopamine ( da ) inhibits the mcp-mediated aldosterone secretion in man . | NA | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
62,
74
]
} | {
"id": "C0013030",
"name": "dopamine",
"pos": [
130,
138
]
} |
thus our conclusions are as follows : a marked increase in blood glucose after oral glucose load was observed in spite of normal insulin-glucose ratio in hyperthyroid children , suggesting the existence of peripheral insulin resistance . | NA | {
"id": "C0005802",
"name": "in blood glucose",
"pos": [
56,
72
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
137,
144
]
} |
when morbidity rates were compared between different ethnic groups , over-weight and normal weight patients , pre- and post-menopausal women , it was not possible to define a group which is at a higher risk for post-operative morbidity . | NA | {
"id": "C0497406",
"name": "over-weight",
"pos": [
69,
80
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
92,
98
]
} |
cerebral haemorrhage in a pregnant woman with a multiple endocrine neoplasia syndrome ( type 2a or sipple 's syndrome ) . | NA | {
"id": "C0027662",
"name": "multiple endocrine neoplasia",
"pos": [
48,
76
]
} | {
"id": "C0025268",
"name": "sipple 's syndrome",
"pos": [
99,
117
]
} |
extensive studies revealed that the patient was suffering from a multiple endocrine neoplasia syndrome ( type 2a or sipple 's syndrome ) with bilateral pheochromocytomas and a medullary thyroid carcinoma . | NA | {
"id": "C0027662",
"name": "multiple",
"pos": [
65,
73
]
} | {
"id": "C0025268",
"name": "sipple 's syndrome",
"pos": [
116,
134
]
} |
the changes in the phospholipid and fatty acid composition of liver plasma membranes isolated from rats , fed two different diets , containing either saturated or unsaturated fatty acids , were investigated . | NA | {
"id": "C0015684",
"name": "fatty acid",
"pos": [
36,
46
]
} | {
"id": "C0015690",
"name": "unsaturated fatty acids",
"pos": [
163,
186
]
} |
feeding of ethanol decreased the rate of synthesis of mixed cardiac proteins but was without effect on the rate of breakdown of myofibrillar and sarcoplasmic proteins . | NA | {
"id": "C0034861",
"name": "synthesis",
"pos": [
41,
50
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
158,
166
]
} |
the role of the pinosome-lysosome pathway in the degradation of 125i-labelled bovine insulin by cultured human fibroblasts was examined by comparing the effects of various known inhibitors of pinocytosis and lysosomal degradation on the uptake and degradation of 125i-labelled polyvinylpyrrolidone , formaldehyde-denatur... | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
111,
122
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
372,
377
]
} |
cholesterol feeding resulted in a clear increase of the amounts of both free and esterified cholesterol . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
0,
11
]
} | {
"id": "C0008387",
"name": "esterified cholesterol",
"pos": [
81,
103
]
} |
these amino acid analogues share the same ph optimum as glutamate , unlike the monocarboxylic amino acids including alanine and norvaline , and give linear double-reciprocal plots under the conditions used here . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
94,
105
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
116,
123
]
} |
clomiphene citrate and ovarian wedge resection decreased luteal phase fsh and lh levels , increased serum estradiol and resulted in frequent ovulations ( clomiphene 80 % , wedge resection 45 % , wedge resection + clomiphene 67 % ) and pregnancies ( clomiphene 60 % , wedge resection 36 % , wedge resection + 67 % ) , whe... | NA | {
"id": "C0546859",
"name": "clomiphene citrate",
"pos": [
0,
18
]
} | {
"id": "C0009008",
"name": "clomiphene",
"pos": [
249,
259
]
} |
one hundred per cent of the strains tested have proved to be sensitive to the sulphonamides and to novobiocin , 93.0 % to the combination of trimethoprim and sulfamethoxazole ( co-trimoxazole ) ; | NA | {
"id": "C0038689",
"name": "sulfamethoxazole",
"pos": [
158,
174
]
} | {
"id": "C0041044",
"name": "co-trimoxazole",
"pos": [
177,
191
]
} |
igf i and igf ii are two insulin-like growth factors resembling insulin in many respects . | NA | {
"id": "C0021665",
"name": "igf i",
"pos": [
0,
5
]
} | {
"id": "C0037657",
"name": "insulin-like growth factors",
"pos": [
25,
52
]
} |
igf i and igf ii are two insulin-like growth factors resembling insulin in many respects . | NA | {
"id": "C0021666",
"name": "igf ii",
"pos": [
10,
16
]
} | {
"id": "C0037657",
"name": "insulin-like growth factors",
"pos": [
25,
52
]
} |
complex ventricular ectopic activity ( multiform extrasystoles , couplets and ventricular tachycardia ) recorded during 24 hour ambulatory electrocardiogram was seen to be predictive of death and non fatal mi . | NA | {
"id": "C0151636",
"name": "ventricular ectopic activity",
"pos": [
8,
36
]
} | {
"id": "C0340464",
"name": "extrasystoles",
"pos": [
49,
62
]
} |
extrapolation of these data and review of the literature suggest that much of the confusion concerning the relationship between hiatal hernia and reflux esophagitis is based on reports of populations with considerable variation in the prevalence of esophagitis and in which the radiographic criteria for diagnosing hiata... | NA | {
"id": "C0014869",
"name": "reflux",
"pos": [
146,
152
]
} | {
"id": "C0014868",
"name": "esophagitis",
"pos": [
249,
260
]
} |
antibody-forming cells against trinitrophenylated sheep red blood cells ( tnp-srbc ) were induced to similar extents , when peripheral blood mononuclear cells from normal individuals , non-responders to hb vaccine inoculation and asymptomatic hbv carriers were stimulated in vitro with pokeweed mitogen ( pwm ) . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
17,
22
]
} | {
"id": "C1321301",
"name": "peripheral blood mononuclear",
"pos": [
124,
152
]
} |
the increased content of glycosaminoglycans with advancing liver cirrhosis was related to those of heparan sulfate and dermatan sulfate components . | NA | {
"id": "C0017973",
"name": "glycosaminoglycans",
"pos": [
25,
43
]
} | {
"id": "C0019143",
"name": "heparan sulfate",
"pos": [
99,
114
]
} |
in the second limb of the study , the half-life of peptide yy ( 11.7 +/- 21 min ) and the metabolic clearance rate ( 13.8 +/- 1.6 ml/kg x min ) were found to be similar to those of other gastrointestinal hormones . | NA | {
"id": "C0070358",
"name": "peptide yy",
"pos": [
51,
61
]
} | {
"id": "C0017182",
"name": "gastrointestinal hormones",
"pos": [
187,
212
]
} |
gdp and gpp ( nh ) p behaved as gtp but other purine nucleotides and nucleosides did not show any effect . | NA | {
"id": "C0018366",
"name": "gpp ( nh ) p",
"pos": [
8,
20
]
} | {
"id": "C0018353",
"name": "gtp",
"pos": [
32,
35
]
} |
comparison of spermatogenetic events , androgen-dependent sex accessory structures , and plasma androgen levels suggests either differential release of pituitary gonadotropins on a seasonal basis or variable testicular responsiveness to gonadotropins . | NA | {
"id": "C0018066",
"name": "pituitary gonadotropins",
"pos": [
152,
175
]
} | {
"id": "C0018061",
"name": "gonadotropins",
"pos": [
237,
250
]
} |
the collaborative lipid research clinics family study : biological and cultural determinants of familial resemblance for plasma lipids and lipoproteins . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
18,
23
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
139,
151
]
} |
in view of the complex , intraindividual relationships among different lipoprotein levels ( ldl-c , hdl-c , and vldl-c ) , multivariate methods aimed at assessing joint familial associations and their possible determinants were performed in the white , random sample component of the collaborative lipid research clinics... | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
71,
82
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
298,
303
]
} |
submaximal pentagastrin stimulated ( 0.25 micrograms/kg/h ) gastric acid secretion , as well as basal gastrin concentrations were studied in two groups of subjects . | NA | {
"id": "C0030859",
"name": "pentagastrin",
"pos": [
11,
23
]
} | {
"id": "C0017151",
"name": "gastrin",
"pos": [
102,
109
]
} |
it is suggested that dopamine and perhaps noradrenaline , but not adrenaline , are important in these effects . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
42,
55
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
66,
76
]
} |
nicardipine significantly increased cholesterol in high density lipoprotein ( hdl-c ) and phospholipid in hdl ( hdl-pl ) with cholesterol and normal diets , and it decreased triglyceride and improved the atherogenic index `` '' ( total cholesterol-hdl-c ) /hdl-c '' '' with the normal diet . | NA | {
"id": "C0023822",
"name": "cholesterol",
"pos": [
36,
47
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
236,
247
]
} |
the apparent serum clearance of phenytoin , primidone , phenobarbitone derived from primidone and valproic acid increased during pregnancy and puerperium . | NA | {
"id": "C0031412",
"name": "phenobarbitone",
"pos": [
56,
70
]
} | {
"id": "C0033148",
"name": "primidone",
"pos": [
84,
93
]
} |
present study was undertaken to elucidate the reflex effects of cutaneous mechanical stimulation on both adrenal sympathetic efferent nerve activity and secretion rates of the adrenal catecholamines ( epinephrine and norepinephrine ) in anesthetized rats . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
201,
212
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
217,
231
]
} |
in hyperprolactinemia , menstrual disorders ranging from irregular bleeding , insufficient luteal phase , spanio-amenorrhea , to anovulatory cycles and amenorrhea , are frequent . | NA | {
"id": "C0025345",
"name": "menstrual disorders",
"pos": [
24,
43
]
} | {
"id": "C0002453",
"name": "amenorrhea",
"pos": [
152,
162
]
} |
the frequency of postoperative normalisation of plasma prolactin ( prl ) depends on prolactinoma size , preoperative prl level , duration of first clinical symptom , previous oestroprogestative contraception , and adenoma necrosis . | NA | {
"id": "C0033375",
"name": "prolactinoma",
"pos": [
84,
96
]
} | {
"id": "C0001430",
"name": "adenoma",
"pos": [
214,
221
]
} |
selective adenomectomy remains an interesting treatment for prolactinoma , particularly if the adenoma is small , recent and with prl moderately increased . | NA | {
"id": "C0033375",
"name": "prolactinoma",
"pos": [
60,
72
]
} | {
"id": "C0001430",
"name": "adenoma",
"pos": [
95,
102
]
} |
mycosis fungoides and the sezary syndrome share common cutaneous histopathologic features , and this spectrum of malignant disease is referred to here as cutaneous t-cell lymphoma ( ctcl ) . | NA | {
"id": "C0036920",
"name": "sezary syndrome",
"pos": [
26,
41
]
} | {
"id": "C0079773",
"name": "cutaneous t-cell lymphoma",
"pos": [
154,
179
]
} |
in addition , cryostat sections were tested with drc 1 monoclonal antibody to dendritic reticulum cells ( drcs ) in three cases and with okt6 antibody to interdigitating reticulum cells ( ircs ) in nine cases . | NA | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
55,
74
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
142,
150
]
} |
the considerable progress which has been made in the molecular analysis of c2 , factor b and c4 using dna clones forms the basis for the future study of the biology of the class iii genes and the role of complement in inflammatory processes and in the immune system . | NA | {
"id": "C0033453",
"name": "factor b",
"pos": [
80,
88
]
} | {
"id": "C0009498",
"name": "complement",
"pos": [
204,
214
]
} |
this review summarises our current knowledge of the genetic organisation , structure and polymorphism of the loci for the complement proteins , c2 and factor b -- class iii gene products of the major histocompatibility complex . | NA | {
"id": "C0009498",
"name": "complement proteins",
"pos": [
122,
141
]
} | {
"id": "C0033453",
"name": "factor b",
"pos": [
151,
159
]
} |
although , for the moment , there is no complementary evidence for a role for ts in oral tolerance to denatured proteins , this study is consistent with the idea that ts are the mechanism which normally prevent enteropathy due to dth against dietary proteins . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
112,
120
]
} | {
"id": "C0012177",
"name": "dietary proteins",
"pos": [
242,
258
]
} |
a recent outbreak of bacillary dysentery in the netherlands revealed that , despite the close association of hla-b27 with post-dysenteric or reactive arthritis ( rea ) , not even in one family did all hla-b27 positive patients infected by an arthritogenic bacterium , develop rea . | NA | {
"id": "C1527298",
"name": "bacillary dysentery",
"pos": [
21,
40
]
} | {
"id": "C0013369",
"name": "dysenteric",
"pos": [
127,
137
]
} |
after incubation of human monocyte-derived macrophages with alpha-l-fucosidase , a glycosidase which splits terminal alpha-l-fucose from oligosaccharides , the macrophages were no longer able to respond to lipopolysaccharide ( lps ) . | NA | {
"id": "C0016787",
"name": "alpha-l-fucosidase",
"pos": [
60,
78
]
} | {
"id": "C0017976",
"name": "glycosidase",
"pos": [
83,
94
]
} |
recombinant inbred strains were used to demonstrate the existence of a major locus on chromosome 1 , designated sap , which controls the endogenous concentration of the mouse acute phase reactant , serum amyloid p-component ( sap ) . | NA | {
"id": "C0001347",
"name": "acute phase reactant",
"pos": [
175,
195
]
} | {
"id": "C0002721",
"name": "serum amyloid p-component",
"pos": [
198,
223
]
} |
analysis of the samples with antibody to secretory component showed that secretory iga as well as serum iga was degraded . | NA | {
"id": "C0036538",
"name": "secretory component",
"pos": [
41,
60
]
} | {
"id": "C0020838",
"name": "secretory iga",
"pos": [
73,
86
]
} |
supernatants from antigen- and immune complex-treated monolayers demonstrated greater inhibitory effects than did supernatants from antibody-treated or untreated monolayers . | NA | {
"id": "C0003313",
"name": "immune complex",
"pos": [
31,
45
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
132,
140
]
} |
when sepsis or bacteriuria occurred after two days of hospitalization , the uti was considered nosocomial . | NA | {
"id": "C0004659",
"name": "bacteriuria",
"pos": [
15,
26
]
} | {
"id": "C0042029",
"name": "uti",
"pos": [
76,
79
]
} |
in a preliminary in vitro checkerboard study the bactericidal effect of various cephalosporins ( cephalothin , cefamandole , cefotaxime and cefoperazone ) in combination with other antibiotics ( netilmicin , amikacin , vancomycin and fosfomycin ) was studied on ten m-r staphylococcal strains . | NA | {
"id": "C0007541",
"name": "cefamandole",
"pos": [
111,
122
]
} | {
"id": "C0007552",
"name": "cefoperazone",
"pos": [
140,
152
]
} |
because this impact on the physiological balance is known to be causative for severe nosocomial infections and is mainly seen with antibiotics that are massively excreted via the bile ( e.g . broadspectrum penicillins , ceftriaxone and cefoperazone ) , we investigated cefotaxime ( ctx ) , cefotiam ( ctm ) , cefmenoxime... | NA | {
"id": "C0007561",
"name": "ceftriaxone",
"pos": [
220,
231
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
269,
279
]
} |
because this impact on the physiological balance is known to be causative for severe nosocomial infections and is mainly seen with antibiotics that are massively excreted via the bile ( e.g . broadspectrum penicillins , ceftriaxone and cefoperazone ) , we investigated cefotaxime ( ctx ) , cefotiam ( ctm ) , cefmenoxime... | NA | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
269,
279
]
} | {
"id": "C0007556",
"name": "cefotiam",
"pos": [
290,
298
]
} |
because this impact on the physiological balance is known to be causative for severe nosocomial infections and is mainly seen with antibiotics that are massively excreted via the bile ( e.g . broadspectrum penicillins , ceftriaxone and cefoperazone ) , we investigated cefotaxime ( ctx ) , cefotiam ( ctm ) , cefmenoxime... | NA | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
269,
279
]
} | {
"id": "C0007549",
"name": "cefmenoxime",
"pos": [
309,
320
]
} |
because this impact on the physiological balance is known to be causative for severe nosocomial infections and is mainly seen with antibiotics that are massively excreted via the bile ( e.g . broadspectrum penicillins , ceftriaxone and cefoperazone ) , we investigated cefotaxime ( ctx ) , cefotiam ( ctm ) , cefmenoxime... | NA | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
269,
279
]
} | {
"id": "C0007560",
"name": "ceftizoxime",
"pos": [
353,
364
]
} |
the pharmacokinetics of cefotaxime , its desacetyl metabolite and ceftriaxone were studied in 72 patients with various degrees of renal and hepatic failure . | NA | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
24,
34
]
} | {
"id": "C0007561",
"name": "ceftriaxone",
"pos": [
66,
77
]
} |
patients with severe renal failure ( creatinine clearance 3 to 10 ml/min ) had a cefotaxime serum half-life of 2.6 h , a desacetyl cefotaxime serum half-life of 10 h and ceftriaxone serum half-life of 17 h . | NA | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
81,
91
]
} | {
"id": "C0007561",
"name": "ceftriaxone",
"pos": [
170,
181
]
} |
products of immune cells such as transfer factor and lymphokines form the third and possibly most important group of immune-stimulating agents . | NA | {
"id": "C0040673",
"name": "transfer factor",
"pos": [
33,
48
]
} | {
"id": "C0024297",
"name": "lymphokines",
"pos": [
53,
64
]
} |
such antibodies , of both the igg and the igm isotype , opsonized e. coli k13 in vitro and protected against intraperitoneal infection in mice as well as ascending pyelonephritis in rats . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
5,
15
]
} | {
"id": "C0021017",
"name": "isotype",
"pos": [
46,
53
]
} |
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