text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
the allergen which is immunologically identical with the allergen formerly denoted as antigen 30 had an isoelectric point of 9.45 . | NA | {
"id": "C0002092",
"name": "allergen",
"pos": [
4,
12
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
86,
93
]
} |
the allergen did not bind yariv artificial galactosyl- and glucosyl-carbohydrate-binding antigens or a monoclonal antibody against ryegrass pollen glycoprotein allergens . | NA | {
"id": "C0002092",
"name": "allergen",
"pos": [
4,
12
]
} | {
"id": "C0003320",
"name": "antigens",
"pos": [
89,
97
]
} |
monoclonal antibodies against cell surface antigens ( okt3 , okt4 , okt8 , and okial ) and antibodies to immunoglobulin heavy chains ( gamma , mu , alpha and delta ) were used for immunofluorescent staining . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
0,
21
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
91,
101
]
} |
programs for nutrition support of patients with phenylketonuria , maternal phenylketonuria , branched chain ketoaciduria and vitamin b-6 non-responsive homocystinuria were written in basic . | NA | {
"id": "C0031485",
"name": "phenylketonuria",
"pos": [
48,
63
]
} | {
"id": "C0085547",
"name": "maternal",
"pos": [
66,
74
]
} |
the characters of these antibodies are compared with those of anti-htlv-1 gp21 mab ( ta-21 , igg1 ) , anti-htlv-i p19 mab ( gin-14 , igg1 ) and human antibodies from patients with adult t-cell leukemia ( atl ) . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
24,
34
]
} | {
"id": "C0003250",
"name": "mab",
"pos": [
118,
121
]
} |
in competitive binding-inhibition assays , these antibodies partially inhibited the binding of 125i-ncrc-11 antibody to antigen , suggesting that the epitopes involved are topographically closely associated . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
120,
127
]
} | {
"id": "C0003316",
"name": "epitopes",
"pos": [
150,
158
]
} |
sandwich immunoassays demonstrated that ncrc-11 epitopes are likely to represent repeated structures of the ncrc-11 antigen . | NA | {
"id": "C0003316",
"name": "epitopes",
"pos": [
48,
56
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
116,
123
]
} |
the findings presented are interpreted as indicating that the ncrc-11 antigen expresses a variety of epitopes which are associated with normal differentiation and malignant change . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
70,
77
]
} | {
"id": "C0003316",
"name": "epitopes",
"pos": [
101,
109
]
} |
the study , when extended to examine the effect of antacid on steady-state kinetics of salicylic acid , showed that when the cmin plasma concentrations of salicylic acid were in the region of 15 mg % , the antacid reduced the plasma concentrations and half-life of salicylic acid . | NA | {
"id": "C0022702",
"name": "kinetics",
"pos": [
75,
83
]
} | {
"id": "C0018517",
"name": "half-life",
"pos": [
252,
261
]
} |
remission inducing drug ( r.i.d . ) therapy being mandatory in patients with a chronic progressive disease , and in view of the previous efficacy of gold salts , the patients were put on oral gold , auranofin being administered 3 mg b.i.d . | NA | {
"id": "C0018026",
"name": "gold",
"pos": [
149,
153
]
} | {
"id": "C0004320",
"name": "auranofin",
"pos": [
199,
208
]
} |
serum levels of acute phase proteins ( c-reactive protein , alpha 1 acid glycoprotein , and haptoglobin ) have been measured to assess the effects of a nonsteroidal antiinflammatory drug ( niflumic acid ) . | NA | {
"id": "C0001347",
"name": "acute phase proteins",
"pos": [
16,
36
]
} | {
"id": "C0006560",
"name": "c-reactive protein",
"pos": [
39,
57
]
} |
serum levels of acute phase proteins ( c-reactive protein , alpha 1 acid glycoprotein , and haptoglobin ) have been measured to assess the effects of a nonsteroidal antiinflammatory drug ( niflumic acid ) . | NA | {
"id": "C0001347",
"name": "acute phase proteins",
"pos": [
16,
36
]
} | {
"id": "C0029297",
"name": "alpha 1 acid",
"pos": [
60,
72
]
} |
serum levels of acute phase proteins ( c-reactive protein , alpha 1 acid glycoprotein , and haptoglobin ) have been measured to assess the effects of a nonsteroidal antiinflammatory drug ( niflumic acid ) . | NA | {
"id": "C0001347",
"name": "acute phase proteins",
"pos": [
16,
36
]
} | {
"id": "C0018595",
"name": "haptoglobin",
"pos": [
92,
103
]
} |
plasma noradrenaline increases were 2.7-fold and 7.9-fold during the 90- and 45-min exercises , respectively , whereas the plasma adrenaline concentration was significantly elevated only after the 45-min exercise ( 4.7-fold ) . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
7,
20
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
130,
140
]
} |
the difference was significant ( p less than 0.05 ) during days 9-16 and 17-24 for both prostaglandins , and during days 1-8 for prostaglandin f 2 alpha only . | NA | {
"id": "C0033554",
"name": "prostaglandins",
"pos": [
88,
102
]
} | {
"id": "C0033561",
"name": "prostaglandin f",
"pos": [
129,
144
]
} |
single chain des- ( b30 ) insulin ( sci ) has been synthesized from porcine insulin by trypsin in a medium with a low content of water . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
26,
33
]
} | {
"id": "C0724601",
"name": "porcine insulin",
"pos": [
68,
83
]
} |
model product analysis studies of dna base damage , inorganic phosphate release , single-strand breaks and incorporation of radioactively labelled sensitizer into dna show a correspondence between the electronic-affinic radiosensitization of dna damage and cell killing . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
34,
37
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
253,
254
]
} |
a short ( 5 min ) incubation of cultured chinese hamster fibroblasts with the specific beta-agonist isoproterenol ( 1 microm ) leads to an increase in the intracellular content of camp and a decrease in radiosensitivity of the cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
57,
68
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
227,
232
]
} |
serum amyloid a protein ( saa ) and c-reactive protein ( crp ) are acute-phase reactants synthesized by the liver . | NA | {
"id": "C0002723",
"name": "saa",
"pos": [
26,
29
]
} | {
"id": "C0001347",
"name": "acute-phase",
"pos": [
67,
78
]
} |
serum amyloid a protein ( saa ) and c-reactive protein ( crp ) are acute-phase reactants synthesized by the liver . | NA | {
"id": "C0006560",
"name": "c-reactive protein",
"pos": [
36,
54
]
} | {
"id": "C0001347",
"name": "acute-phase",
"pos": [
67,
78
]
} |
other parameters studied included etiology , bacterial sensitivity , infection related to the six surgical groups functioning in the division and to the indication for elective or emergency surgery , respiratory infection , respiratory infection related to the anesthetist who administered the general anesthesia and wou... | NA | {
"id": "C0009450",
"name": "infection",
"pos": [
69,
78
]
} | {
"id": "C0035243",
"name": "respiratory infection",
"pos": [
224,
245
]
} |
other parameters studied included etiology , bacterial sensitivity , infection related to the six surgical groups functioning in the division and to the indication for elective or emergency surgery , respiratory infection , respiratory infection related to the anesthetist who administered the general anesthesia and wou... | NA | {
"id": "C0009450",
"name": "infection",
"pos": [
69,
78
]
} | {
"id": "C0043241",
"name": "wound infection",
"pos": [
317,
332
]
} |
when given in comparable doses , l-ascorbic acid , sodium ascorbate , and dehydroascorbate were equally effective in preserving rhodopsin . | NA | {
"id": "C0003968",
"name": "l-ascorbic acid",
"pos": [
33,
48
]
} | {
"id": "C0887557",
"name": "sodium",
"pos": [
51,
57
]
} |
many microorganisms and compounds of microbial origin exhibit immunomodulatory activities and have been extensively used in immunotherapy of experimental animal tumors and in patients with neoplasia . | NA | {
"id": "C0027659",
"name": "experimental",
"pos": [
141,
153
]
} | {
"id": "C0027651",
"name": "neoplasia",
"pos": [
189,
198
]
} |
a successful outcome for the patient who hemorrhages after surgery is based on the recognition of bleeding , the specific diagnosis of bleeding sites and disorders , and the management of bleeding by control measures and replacement of blood lost ( table iii ) . | NA | {
"id": "C0032788",
"name": "hemorrhages after surgery",
"pos": [
41,
66
]
} | {
"id": "C0019080",
"name": "bleeding",
"pos": [
188,
196
]
} |
membrane proteases that are detectable by cytochemical means are the classified exopeptidases , aminopeptidases a and m ( or n ) , gamma-glutamyl transpeptidase ( which also acts as transferase ) , dipeptidyl peptidase iv and the endopeptidase , enteropeptidase ( also known as enterokinase ) . | NA | {
"id": "C0030940",
"name": "proteases",
"pos": [
9,
18
]
} | {
"id": "C0117059",
"name": "exopeptidases",
"pos": [
80,
93
]
} |
membrane proteases that are detectable by cytochemical means are the classified exopeptidases , aminopeptidases a and m ( or n ) , gamma-glutamyl transpeptidase ( which also acts as transferase ) , dipeptidyl peptidase iv and the endopeptidase , enteropeptidase ( also known as enterokinase ) . | NA | {
"id": "C0030940",
"name": "proteases",
"pos": [
9,
18
]
} | {
"id": "C0030946",
"name": "endopeptidase",
"pos": [
230,
243
]
} |
membrane proteases that are detectable by cytochemical means are the classified exopeptidases , aminopeptidases a and m ( or n ) , gamma-glutamyl transpeptidase ( which also acts as transferase ) , dipeptidyl peptidase iv and the endopeptidase , enteropeptidase ( also known as enterokinase ) . | NA | {
"id": "C0117059",
"name": "exopeptidases",
"pos": [
80,
93
]
} | {
"id": "C0002570",
"name": "aminopeptidases",
"pos": [
96,
111
]
} |
infant milk intake was found to correlate significantly with weight ( r = 0.646 , p less than 0.005 ) and with weight-for-age ( r = 0.640 , p less than 0.005 ) , but a much stronger and highly significant correlation was found with infant birth-weight ( r = 0.802 , p less than 0.001 ) . | NA | {
"id": "C0005910",
"name": "weight",
"pos": [
61,
67
]
} | {
"id": "C0005612",
"name": "infant",
"pos": [
232,
238
]
} |
allografts can be rejected as a result of major histocompatibility antigen disparity or as a result of differences at any of a number of minor histocompatibility antigens . | NA | {
"id": "C0019628",
"name": "histocompatibility antigen",
"pos": [
48,
74
]
} | {
"id": "C0026189",
"name": "minor",
"pos": [
137,
142
]
} |
the stability of cellular fluorescence and possible diffusion of metabolites were examined by flow cytometric analysis of mouse and hamster fibroblasts exposed to nfvo and af-2 . | NA | {
"id": "C0007634",
"name": "cellular",
"pos": [
17,
25
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
140,
151
]
} |
on the basis of histologic features of the cyst wall , ie , association with sebaceous glands and lack of follicular structures or rete pegs , the cysts were classified as follicular cysts . | NA | {
"id": "C0010709",
"name": "cysts",
"pos": [
147,
152
]
} | {
"id": "C0016427",
"name": "follicular cysts",
"pos": [
172,
188
]
} |
gentamicin should be combined with penicillin g or ampicillin and not used for longer than one week without monitoring for nephrotoxicosis . | NA | {
"id": "C0030827",
"name": "penicillin g",
"pos": [
35,
47
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
51,
61
]
} |
cgf obtained from sensitized spleen cells was chromatographically separated from il 1 , il 2 , and colony-stimulating factor , and the chromatographically separated cgf did not contain il 3 activity . | NA | {
"id": "C0009392",
"name": "colony-stimulating factor",
"pos": [
99,
124
]
} | {
"id": "C0021757",
"name": "il 3",
"pos": [
185,
189
]
} |
3 ) the carbohydrates ( primarily galactose , n-acetylglucosamine and n-acetylgalactosamine ) are arranged in short , oligosaccharide chains ( 4-20 monosaccharides per chain ) ; | NA | {
"id": "C0007004",
"name": "carbohydrates",
"pos": [
8,
21
]
} | {
"id": "C0026492",
"name": "monosaccharides",
"pos": [
148,
163
]
} |
two of the strains had glycerol with glucose teichoic acids whilst another possessed glycerol , glucose , glucosamine and acetylglucosamine teichoic acids . | NA | {
"id": "C0017718",
"name": "glucosamine",
"pos": [
106,
117
]
} | {
"id": "C0001056",
"name": "acetylglucosamine",
"pos": [
122,
139
]
} |
activity of cefotaxime and ceftriaxone alone and in combination with penicillin , ampicillin and piperacillin against neonatal meningitis pathogens . | NA | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
12,
22
]
} | {
"id": "C0007561",
"name": "ceftriaxone",
"pos": [
27,
38
]
} |
activity of cefotaxime and ceftriaxone alone and in combination with penicillin , ampicillin and piperacillin against neonatal meningitis pathogens . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
82,
92
]
} | {
"id": "C0031955",
"name": "piperacillin",
"pos": [
97,
109
]
} |
the activities of penicillin g , ampicillin , piperacillin , cefotaxime and ceftriaxone alone and in combination against 130 isolates of escherichia coli , group b streptococci and listeria monocytogenes from neonatal meningitis were assessed by using agar dilution , checkerboard and time-kill techniques . | NA | {
"id": "C0030827",
"name": "penicillin g",
"pos": [
18,
30
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
33,
43
]
} |
the activities of penicillin g , ampicillin , piperacillin , cefotaxime and ceftriaxone alone and in combination against 130 isolates of escherichia coli , group b streptococci and listeria monocytogenes from neonatal meningitis were assessed by using agar dilution , checkerboard and time-kill techniques . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
33,
43
]
} | {
"id": "C0031955",
"name": "piperacillin",
"pos": [
46,
58
]
} |
the activities of penicillin g , ampicillin , piperacillin , cefotaxime and ceftriaxone alone and in combination against 130 isolates of escherichia coli , group b streptococci and listeria monocytogenes from neonatal meningitis were assessed by using agar dilution , checkerboard and time-kill techniques . | NA | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
61,
71
]
} | {
"id": "C0007561",
"name": "ceftriaxone",
"pos": [
76,
87
]
} |
cefotaxime and ceftriaxone were highly active against e. coli and group b streptococci ( mic90 0.05-0.1 mg/1 ) but not active against list . monocytogenes . | NA | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
0,
10
]
} | {
"id": "C0007561",
"name": "ceftriaxone",
"pos": [
15,
26
]
} |
penicillin g was more active than ampicillin and piperacillin against group b streptococci ( mic90 0.1 , 0.12 and 0.24 mg/l respectively ) and ampicillin was the most active against list . monocytogenes ( mic90 0.6 mg/l ) . | NA | {
"id": "C0030827",
"name": "penicillin g",
"pos": [
0,
12
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
143,
153
]
} |
penicillin g was more active than ampicillin and piperacillin against group b streptococci ( mic90 0.1 , 0.12 and 0.24 mg/l respectively ) and ampicillin was the most active against list . monocytogenes ( mic90 0.6 mg/l ) . | NA | {
"id": "C0031955",
"name": "piperacillin",
"pos": [
49,
61
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
143,
153
]
} |
a significant delay in killing of group b streptococci was observed with penicillin g-cephalosporin and ampicillin-cephalosporin combinations . | NA | {
"id": "C0030827",
"name": "penicillin g",
"pos": [
73,
85
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
104,
114
]
} |
cefuroxime axetil , an orally absorbed pro-drug of cefuroxime was used to treat a mainly elderly group of patients with symptomatic urinary tract infections . | NA | {
"id": "C0055015",
"name": "cefuroxime axetil",
"pos": [
0,
17
]
} | {
"id": "C0007562",
"name": "cefuroxime",
"pos": [
51,
61
]
} |
the binding of a modified bovine albumin to the fa-hq gel showed that the blocking of the amino groups in the albumin molecule decreased the amount of protein bound to the gel . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
33,
40
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
151,
158
]
} |
the lactating guinea-pig mammary gland synthesizes and secretes four major milk proteins , i.e. , three caseins and alpha-lactalbumin . | NA | {
"id": "C0026138",
"name": "milk",
"pos": [
75,
79
]
} | {
"id": "C0007332",
"name": "caseins",
"pos": [
104,
111
]
} |
the microinjection of milk protein mrna into xenopus oocytes in the presence of [ 35s ] methionine leads to the synthesis , sequestration , and secretion of proteins which coelectrophorese with alpha-lactalbumin and with partially processed caseins . | NA | {
"id": "C0026138",
"name": "milk protein",
"pos": [
22,
34
]
} | {
"id": "C0007332",
"name": "caseins",
"pos": [
241,
248
]
} |
the muscle contents of high-energy phosphates and their derivatives [ atp , adp , amp , creatine phosphate ( crp ) , and creatine ] , glycogen , some glycolytic intermediates , pyruvate , and lactate were compared in 11 dogs performing prolonged heavy exercise until exhaustion ( at ambient temperature 20.0 +/- 1.0 degr... | NA | {
"id": "C0031634",
"name": "creatine phosphate",
"pos": [
88,
106
]
} | {
"id": "C0010286",
"name": "creatine",
"pos": [
121,
129
]
} |
caffeine caused a significant fall in plasma norepinephrine and an increase in plasma epinephrine in both groups of subjects , but this action was significantly greater in trained subjects . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
45,
59
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
86,
97
]
} |
in contrast , protein clearance ( as measured by 125i-albumin instilled with the serum ) was monoexponential and slow ( 1 % /h ) . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
14,
21
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
54,
61
]
} |
because protein solutions are chemotactic for neutrophils , we quantified the movement of liquid from the extracellular space into the alveolar compartment with a plasma protein tracer ( 131i-albumin ) , so that our final calculation of alveolar liquid clearance would take into account bidirectional movement of liquid ... | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
8,
15
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
192,
199
]
} |
we therefore measured ne , epinephrine ( e ) , and vo2 at rest and during graded maximal treadmill exercise in 24 healthy male volunteers ( ages 22-77 yr ) from the baltimore longitudinal study of aging who were rigorously screened to exclude the presence of cardiovascular disease . | NA | {
"id": "C0028351",
"name": "ne",
"pos": [
22,
24
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
27,
38
]
} |
fixed negative charges located on endothelial cells , basement membrane , and interstitial matrix could explain the observed differences between ldh isozymes in cl/cp ratios , tissue uptake , and extra-vascular distribution volumes by the ionic interaction of ldh 5 with these negative change sites which would retard th... | NA | {
"id": "C0022023",
"name": "ionic",
"pos": [
239,
244
]
} | {
"id": "C0007447",
"name": "cationic",
"pos": [
426,
434
]
} |
other mycotoxins detected were patulin and a number of trichothecene toxins at incidence rates in all commodities of 5.6 and 3.1 % , respectively . | NA | {
"id": "C0026955",
"name": "mycotoxins",
"pos": [
6,
16
]
} | {
"id": "C0030710",
"name": "patulin",
"pos": [
31,
38
]
} |
other mycotoxins detected were patulin and a number of trichothecene toxins at incidence rates in all commodities of 5.6 and 3.1 % , respectively . | NA | {
"id": "C0026955",
"name": "mycotoxins",
"pos": [
6,
16
]
} | {
"id": "C0040549",
"name": "toxins",
"pos": [
69,
75
]
} |
a method of determining total penicillins begins with an enzymatic hydrolysis of the beta-lactam ring to form their respective penicilloate product . | NA | {
"id": "C0030842",
"name": "penicillins",
"pos": [
30,
41
]
} | {
"id": "C0282215",
"name": "beta-lactam",
"pos": [
85,
96
]
} |
the pi of the mutant protein was lower ( 4.9 ) than that of the wild-type protein ( 5.1 ) . | NA | {
"id": "C1564139",
"name": "mutant protein",
"pos": [
14,
28
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
74,
81
]
} |
the rate of heat inactivation of the enzyme followed first-order kinetics , with a half-life of 10 min at 70 degrees c but about 150 min in the presence of 0.5 m ammonium sulfate or 0.5 mg of bovine serum albumin per ml at the same temperature . | NA | {
"id": "C0022702",
"name": "kinetics",
"pos": [
65,
73
]
} | {
"id": "C0018517",
"name": "half-life",
"pos": [
83,
92
]
} |
at a low concentration of d-glucose ( 3.3 mm ) , the phosphorylation rate of this hexose in rat pancreatic islet homogenates incubated at 8 degrees c is higher with the beta- than with the alpha-anomer , as expected from the anomeric specificity of hexokinase . | NA | {
"id": "C0017725",
"name": "glucose",
"pos": [
28,
35
]
} | {
"id": "C0019494",
"name": "hexose",
"pos": [
82,
88
]
} |
to determine whether there was any parallel regulation of the production of these products , the rates of collagen synthesis by cultured chick embryo tibial chondrocytes were altered , and the resulting changes in proteochondroitin sulfate synthesis and alkaline phosphatase levels in the cells were measured . | NA | {
"id": "C0225369",
"name": "chondrocytes",
"pos": [
157,
169
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
289,
294
]
} |
treatments that resulted in an increased level of intracellular cyclic amp , such as treatment with 1-methyl-3-isobutylxanthine , theophylline , dibutyryl cyclic amp , or 8-bromocyclic amp also resulted in an increased rate of 45ca2+ entry via nitrendipine-sensitive ca2+ channel . | NA | {
"id": "C0001455",
"name": "cyclic amp",
"pos": [
64,
74
]
} | {
"id": "C0012054",
"name": "dibutyryl cyclic amp",
"pos": [
145,
165
]
} |
treatments that resulted in an increased level of intracellular cyclic amp , such as treatment with 1-methyl-3-isobutylxanthine , theophylline , dibutyryl cyclic amp , or 8-bromocyclic amp also resulted in an increased rate of 45ca2+ entry via nitrendipine-sensitive ca2+ channel . | NA | {
"id": "C0001455",
"name": "cyclic amp",
"pos": [
64,
74
]
} | {
"id": "C0000661",
"name": "8-bromocyclic amp",
"pos": [
171,
188
]
} |
23 of these compounds comprising 37 % of the recovered radioactivity had prostaglandin f-ring structures , and only two metabolites comprising 2.7 % of the recovered radioactivity retained the prostaglandin d-ring structure . | NA | {
"id": "C0033561",
"name": "prostaglandin f",
"pos": [
73,
88
]
} | {
"id": "C0033554",
"name": "prostaglandin",
"pos": [
193,
206
]
} |
e ii consists of two subunits of molecular mass 41,000 and 48,000 daltons and contains equal amounts of riboflavin and flavin mononucleotide . | NA | {
"id": "C0035527",
"name": "riboflavin",
"pos": [
104,
114
]
} | {
"id": "C0016388",
"name": "flavin mononucleotide",
"pos": [
119,
140
]
} |
the six antibodies , together with four previously characterized anti-a monoclonal antibodies ( originally raised against the receptor for epidermal growth factor ) have been classified into five groups . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
8,
18
]
} | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
72,
93
]
} |
we have examined the interaction of the purified cell-binding domain of fibronectin with fibroblastic baby hamster kidney cells . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
17,
20
]
} | {
"id": "C0016030",
"name": "fibroblastic",
"pos": [
89,
101
]
} |
and the transport site is accessed by solution chloride via an anion channel leading from the transport site to the solution . | NA | {
"id": "C0008203",
"name": "chloride",
"pos": [
47,
55
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
63,
68
]
} |
preincubation of the cells with high concentrations of active phorbol esters abolished specific [ 3h ] phorbol 12,13-dibutyrate binding , protein kinase c activity , and immunoreactivity and also prevented stimulated phosphorylation of the mr 80,000 protein by pma , diacylglycerols , pdgf , or fgf , supporting the cont... | NA | {
"id": "C0031586",
"name": "phorbol esters",
"pos": [
62,
76
]
} | {
"id": "C0039654",
"name": "pma",
"pos": [
261,
264
]
} |
based on the sedimentation of camp-dependent protein kinase and regulatory subunits using sucrose density gradient centrifugation , identification of 8-n3 [ 32p ] camp labeled ri and rii in deae-cellulose column and sucrose gradient fractions by sodium dodecyl sulfate-polyacrylamide gel electrophoresis , and scatchard ... | NA | {
"id": "C0010531",
"name": "camp-dependent protein kinase",
"pos": [
30,
59
]
} | {
"id": "C1956039",
"name": "type i",
"pos": [
620,
626
]
} |
the gene for the prototype acute phase reactant , c-reactive protein , has been isolated from two lambda phage libraries containing inserted human dna fragments using synthetic oligonucleotide probes . | NA | {
"id": "C0001347",
"name": "acute phase reactant",
"pos": [
27,
47
]
} | {
"id": "C0006560",
"name": "c-reactive protein",
"pos": [
50,
68
]
} |
amino acid compositions deduced from the nucleotide sequences are typical for proline-rich proteins : 25-45 % proline , 18-22 % glycine , and 18-22 % glutamine and generally an absence of sulfur-containing amino acids except for the initiator methionine . | NA | {
"id": "C0017890",
"name": "glycine",
"pos": [
128,
135
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
206,
217
]
} |
without rhodopsin , labeling of t alpha ( in the presence of t beta gamma ) was unaffected by gpp ( nh ) p , guanosine 5'-o- ( thiotriphosphate ) ( gtp gamma s ) , gtp , gdp , and guanosine 5'-o- ( thiodiphosphate ) ( gdp beta s ) but was increased by atp . | NA | {
"id": "C0018366",
"name": "gpp ( nh ) p",
"pos": [
94,
106
]
} | {
"id": "C0018353",
"name": "gtp",
"pos": [
164,
167
]
} |
without rhodopsin , labeling of t alpha ( in the presence of t beta gamma ) was unaffected by gpp ( nh ) p , guanosine 5'-o- ( thiotriphosphate ) ( gtp gamma s ) , gtp , gdp , and guanosine 5'-o- ( thiodiphosphate ) ( gdp beta s ) but was increased by atp . | NA | {
"id": "C0079469",
"name": "gtp gamma s",
"pos": [
148,
159
]
} | {
"id": "C0018353",
"name": "gtp",
"pos": [
164,
167
]
} |
isozyme 3a was the most active enzyme in the hydroxylation of acetol , but isozymes 2 , 3b , and 4 also were able to catalyze the reaction . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
31,
37
]
} | {
"id": "C0022173",
"name": "isozymes",
"pos": [
75,
83
]
} |
these results suggest that isozyme 3a in rabbit and an immunochemically homologous enzyme in rat are responsible for acetone and acetol hydroxylation , the initial steps in the proposed gluconeogenic pathways for acetone . | NA | {
"id": "C0022173",
"name": "isozyme",
"pos": [
27,
34
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
83,
89
]
} |
within the predicted amino acid sequence of factor xii , we have identified three peptide bonds that are cleaved by kallikrein during the formation of beta-factor xiia . | NA | {
"id": "C0015525",
"name": "factor xii",
"pos": [
44,
54
]
} | {
"id": "C0015527",
"name": "factor xiia",
"pos": [
156,
167
]
} |
the carboxyl-terminal region of factor xii shares considerable amino acid sequence homology with other serine proteases including trypsin and many clotting factors . | NA | {
"id": "C0036734",
"name": "serine",
"pos": [
103,
109
]
} | {
"id": "C0041236",
"name": "trypsin",
"pos": [
130,
137
]
} |
this result suggests a greater complexity of troponin t gene structure or a greater diversity of troponin t isoform genes than is currently known , and also has implications for the functional significance of the troponin t protein isoform heterogeneity . | NA | {
"id": "C0041199",
"name": "complexity",
"pos": [
31,
41
]
} | {
"id": "C0077404",
"name": "troponin t",
"pos": [
213,
223
]
} |
it is also shown that cultured ehrlich cells do not make extra zinc metallothionein in the presence of high levels of zncl2 , and fail to accumulate copper in the presence of large concentrations of cucl2 . | NA | {
"id": "C0009968",
"name": "copper",
"pos": [
149,
155
]
} | {
"id": "C0056593",
"name": "cucl2",
"pos": [
199,
204
]
} |
this indicated the existence of two types of stable complexes : a vesicular apo-a-i complex with a maximum of two to three apo-a-is/vesicle , and a micellar complex ( disc ) with a stoichiometry of about 50 phosphatidylcholines/apo-a-i ( mol/mol ) . | NA | {
"id": "C0003592",
"name": "apo-a",
"pos": [
76,
81
]
} | {
"id": "C0085201",
"name": "a",
"pos": [
232,
233
]
} |
this proteoglycan is distinctly different from the large cartilage proteoglycan in the smaller size of its core protein , and its relationship to other small chondroitin and dermatan sulfate proteoglycans and to the chondroitin sulfate proteoglycan recently located in rat tissue basement membranes will be discussed . | NA | {
"id": "C0033692",
"name": "proteoglycan",
"pos": [
5,
17
]
} | {
"id": "C0033689",
"name": "chondroitin sulfate proteoglycan",
"pos": [
216,
248
]
} |
we have previously reported that molybdate-stabilized cytosol prepared from 32p-labeled l-cells contains two phosphoproteins ( a 90-92- and a 98-100-kda protein ) that elute from an affinity resin of deoxycorticosterone-derivatized agarose in a manner consistent with the predicted behavior of the glucocorticoid recepto... | NA | {
"id": "C0031689",
"name": "phosphoproteins",
"pos": [
109,
124
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
153,
160
]
} |
consistent with a protein kinase c activity in sarcolemmal vesicles , the tumor-promoting phorbol ester 12-o-tetradecanoylphorbol 13-acetate stimulated 15-kda protein phosphorylation severalfold , producing approximately 70 % of the maximal phosphorylation even in the absence of significant ionized ca2+ . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
90,
103
]
} | {
"id": "C0039654",
"name": "12-o-tetradecanoylphorbol 13-acetate",
"pos": [
104,
140
]
} |
the biological activities of several derivatives of human proinsulin ( hpi ) containing peptide bond cleavages or peptide deletions in the connecting peptide region were examined in vivo in rats and in several in vitro systems . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
58,
68
]
} | {
"id": "C0006558",
"name": "peptide",
"pos": [
150,
157
]
} |
the receptor binding affinities of split ( 65-66 ) hpi , des- ( 57-65 ) hpi , des- ( 64,65 ) hpi , des- ( 33-56 ) hpi , des- ( 31,32 ) hpi , split ( 32-33 ) hpi , and split ( 56-57 ) hpi were examined in cultured im-9 lymphocytes , freshly isolated rat adipocytes , and purified rat liver membranes and were compared to ... | NA | {
"id": "C0033362",
"name": "hpi",
"pos": [
51,
54
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
350,
357
]
} |
modification of proinsulin in the connecting peptide region near the a-chain of insulin to form split ( 65-66 ) hpi , des- ( 57-65 ) hpi , des- ( 64,65 ) hpi , or des- ( 33-56 ) hpi resulted in an increase in affinity for receptor binding ranging from 11 to 27-fold over that of intact hpi . | NA | {
"id": "C0006558",
"name": "connecting peptide",
"pos": [
34,
52
]
} | {
"id": "C0033362",
"name": "hpi",
"pos": [
286,
289
]
} |
in contrast , modifications near the b-chain of insulin to form either des- ( 31,32 ) hpi or split ( 32-33 ) hpi resulted in roughly a 5-fold increase in affinity , whereas a cleavage within the connecting peptide to form split ( 56-57 ) hpi showed only a 2-fold increase in affinity as compared to intact hpi . | NA | {
"id": "C0006558",
"name": "connecting",
"pos": [
195,
205
]
} | {
"id": "C0033362",
"name": "hpi",
"pos": [
306,
309
]
} |
since molybdate stabilizes 10 s oligomeric steroid receptors in vitro , the effects of molybdate on nuclear accumulation of occupied receptors in intact cells support the intracellular existence and physiological relevance of 10 s glucocorticoid and estrogen receptors . | NA | {
"id": "C0034840",
"name": "steroid receptors",
"pos": [
43,
60
]
} | {
"id": "C0034804",
"name": "estrogen receptors",
"pos": [
250,
268
]
} |
moreover , these responses are 10- to 100-fold less sensitive to retinoid than the process of envelope formation , suggesting that at least two sets of processes with different sensitivities to vitamin a are present in keratinocytes . | NA | {
"id": "C0035339",
"name": "retinoid",
"pos": [
65,
73
]
} | {
"id": "C0042839",
"name": "vitamin a",
"pos": [
194,
203
]
} |
pseudomonas testosteroni protocatechuate 4,5-dioxygenase and pseudomonas putida catechol 2,3-dioxygenase ( metapyrocatechase ) catalyze extradiol-type oxygenolytic cleavage of the aromatic ring of their substrates . | NA | {
"id": "C0599874",
"name": "dioxygenase",
"pos": [
45,
56
]
} | {
"id": "C0054860",
"name": "metapyrocatechase",
"pos": [
107,
124
]
} |
this study thus demonstrates the responsiveness of adipocytes to tolbutamide and also establishes the usefulness of 3t3-l1 cells as a model system in which to study the mechanism of tolbutamide action , both as it relates to the use of sulfonylurea compounds in clinical applications and as possible probes for perturbin... | NA | {
"id": "C0040374",
"name": "tolbutamide",
"pos": [
65,
76
]
} | {
"id": "C0038766",
"name": "sulfonylurea compounds",
"pos": [
236,
258
]
} |
cholate-solubilized chick kidney mitochondria that 1-hydroxylated 25-hydroxyvitamin-d3 ( 25-oh-d3 ) upon reconstitution also produced 10-oxo-19-nor-25-oh-d3 , which co-eluted with 1,25-dihydroxyvitamin d3 ( 1,25- ( oh ) 2-d3 ) on normal phase high performance liquid chromatography ( hplc ) with hexane : propanol-2 ( 9:... | NA | {
"id": "C0006657",
"name": "25-hydroxyvitamin-d3",
"pos": [
66,
86
]
} | {
"id": "C2713074",
"name": "25-oh-d3",
"pos": [
148,
156
]
} |
moreover , fasting changed the synthesis and secretion of apolipoproteins selectively : secretion of low molecular weight apo-b was decreased 50 % , large molecular weight apo-b was unchanged , and apo-e was increased 2-4-fold . | NA | {
"id": "C0003591",
"name": "apolipoproteins",
"pos": [
58,
73
]
} | {
"id": "C0003593",
"name": "apo-b",
"pos": [
172,
177
]
} |
moreover , fasting changed the synthesis and secretion of apolipoproteins selectively : secretion of low molecular weight apo-b was decreased 50 % , large molecular weight apo-b was unchanged , and apo-e was increased 2-4-fold . | NA | {
"id": "C0003591",
"name": "apolipoproteins",
"pos": [
58,
73
]
} | {
"id": "C0003595",
"name": "apo-e",
"pos": [
198,
203
]
} |
analysis of the lipoproteins from both groups of cells on bio-gel a-50m showed that the very low density lipoprotein secreted by cells from fasted rats was smaller . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
16,
28
]
} | {
"id": "C0023825",
"name": "very low density",
"pos": [
88,
104
]
} |
the combined data show that : 1 ) the synthesis of individual very low density lipoprotein apolipoproteins is independently regulated , and 2 ) the synthesis ( availability ) of apo-b determines the capacity of the hepatocyte to assemble/secrete triacylglycerol-rich very low density lipoprotein . | NA | {
"id": "C0003591",
"name": "apolipoproteins",
"pos": [
91,
106
]
} | {
"id": "C0003593",
"name": "apo-b",
"pos": [
178,
183
]
} |
analysis of the core peptide of the intact proteoglycan revealed that glycine , serine , and glutamic acid/glutamine accounted for 70 % of the total amino acids and were present in a molar ratio of 4.3/1.6/1.0 . | NA | {
"id": "C0061472",
"name": "glutamic",
"pos": [
93,
101
]
} | {
"id": "C0017797",
"name": "glutamine",
"pos": [
107,
116
]
} |
when analyzed for neutral hexose content by gas-liquid chromatography , the proteoglycan contained approximately 2 % of its weight as mannose , fucose , galactose , and other sugars , indicating that oligosaccharides were linked to the peptide core . | NA | {
"id": "C0019494",
"name": "hexose",
"pos": [
26,
32
]
} | {
"id": "C0024742",
"name": "mannose",
"pos": [
134,
141
]
} |
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