text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
when analyzed for neutral hexose content by gas-liquid chromatography , the proteoglycan contained approximately 2 % of its weight as mannose , fucose , galactose , and other sugars , indicating that oligosaccharides were linked to the peptide core . | NA | {
"id": "C0019494",
"name": "hexose",
"pos": [
26,
32
]
} | {
"id": "C0016945",
"name": "galactose",
"pos": [
153,
162
]
} |
priming human fibroblasts with low levels ( 100 units/ml ) of homologous interferon ( ifn ) prior to induction of gene expression with poly ( ri.rc ) results in the accumulation of 5-10-fold higher levels of ifn-beta 1 mrna when compared to induced but nonprimed cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
14,
25
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
263,
268
]
} |
a collection of monoclonal antibodies against dictyostelium myosin was screened to identify an antibody that could distinguish monomeric from polymeric myosin . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
16,
37
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
95,
103
]
} |
multiple biosynthetic forms of glucocerebrosidase were immunoprecipitated after synthesis in vitro using cell-free translation or in vivo using pulse-chase conditions in porcine kidney cells or human fibroblasts . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
185,
190
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
200,
211
]
} |
the same forms were precipitated from human fibroblasts but the rate of processing was accelerated in this cell type . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
44,
55
]
} | {
"id": "C0007634",
"name": "cell type",
"pos": [
107,
116
]
} |
isolated rat liver nuclei were allowed to elongate nascent rna transcripts in the presence of [ alpha-32p ] ctp , and radiolabeled nuclear reductase rna was quantitated by filter hybridization . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
59,
62
]
} | {
"id": "C0035700",
"name": "nuclear",
"pos": [
131,
138
]
} |
cells cultured under serum-free conditions were treated with human chorionic gonadotropin ( hcg ) or 8-bromo-camp alone or in combination with aminoglutethimide ( to block conversion of cholesterol to steroid hormones ) and 5-cholesten-3 beta , 25-diol ( 25-hydroxycholesterol , a potent suppressor of ldl receptor expre... | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
0,
5
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
335,
346
]
} |
based on a partial amino acid sequence for a tryptic peptide of adp-ribosylated transducin , asparagine had been characterized as the site of pertussis toxin-catalyzed adp-ribosylation . | NA | {
"id": "C0301714",
"name": "based",
"pos": [
0,
5
]
} | {
"id": "C0003995",
"name": "asparagine",
"pos": [
93,
103
]
} |
one molecule of dna topoisomerase ii is able to catenate about 20 circles of relaxed dna/min at 30 degrees c but only 0.16 circle of supercoiled dna/min at 30 degrees c . | NA | {
"id": "C0012925",
"name": "circles",
"pos": [
66,
73
]
} | {
"id": "C0012937",
"name": "supercoiled dna",
"pos": [
133,
148
]
} |
we have studied putative nicotinic acetylcholine receptors in the optic lobe of the newborn chick , using 125i-labeled alpha-bungarotoxin , a specific blocker of acetylcholine receptors in the neuromuscular junction , and [ 3h ] acetylcholine , a ligand which in the presence of atropine selectively labels binding sites... | NA | {
"id": "C0034792",
"name": "acetylcholine receptors",
"pos": [
35,
58
]
} | {
"id": "C0034830",
"name": "binding sites",
"pos": [
307,
320
]
} |
the first one , already described for the enzyme stored for some months in aerobic conditions , is a slow activation by molecular hydrogen or a reducing medium ( half-reaction time = 2 h ) . | NA | {
"id": "C0020275",
"name": "hydrogen",
"pos": [
130,
138
]
} | {
"id": "C0011744",
"name": "2 h",
"pos": [
183,
186
]
} |
immune complexes formed between the antibody and either human or rat erythropoietin exhibit full biologic activity . | NA | {
"id": "C0003313",
"name": "immune",
"pos": [
0,
6
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
36,
44
]
} |
the rate-limiting step in the processing of the asparagine-linked glycans of laminin is at the point of action of alpha-mannosidase i since the principal laminin forms that accumulate in jar cells contain man9glcnac2 and man8glcnac2 oligosaccharide units . | NA | {
"id": "C0032594",
"name": "glycans",
"pos": [
66,
73
]
} | {
"id": "C0028959",
"name": "oligosaccharide",
"pos": [
233,
248
]
} |
furthermore , our transcription results in vitro , as well as northern blot analysis , show that the short-chain fatty acid , sodium butyrate , totally blocks this hydrocortisone-induced transcription of glycerol phosphate dehydrogenase , demonstrating that the site of action of this fatty acid resides in the cell nucl... | NA | {
"id": "C0015691",
"name": "short-chain fatty acid",
"pos": [
101,
123
]
} | {
"id": "C0015684",
"name": "fatty acid",
"pos": [
285,
295
]
} |
erythrocyte clathrin is not identical to brain clathrin since antibody raised against the erythrocyte protein reacts better with erythrocyte clathrin than with brain clathrin and since brain clathrin contains two light chains resolved on sodium dodecyl sulfate gels while the light chain of erythrocyte clathrin migrates... | NA | {
"id": "C0008905",
"name": "clathrin",
"pos": [
12,
20
]
} | {
"id": "C1135987",
"name": "light chain",
"pos": [
276,
287
]
} |
in contrast , gamma subunits associated with frog and bovine transducin differed markedly between each other and from n protein-associated gamma . beta subunits , on the other hand , yielded essentially indistinguishable peptide maps regardless of whether derived from n proteins or from transducin and regardless also o... | NA | {
"id": "C0599220",
"name": "protein",
"pos": [
120,
127
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
271,
279
]
} |
the possibility of using a reference standard of almost pure neomycin b for both the determination of framycetin and neomycin was evaluated . | NA | {
"id": "C0016673",
"name": "framycetin",
"pos": [
102,
112
]
} | {
"id": "C0027603",
"name": "neomycin",
"pos": [
117,
125
]
} |
evidence for vagal involvement in the electrophysiologic actions of exogenous adenosine and adenosine triphosphate in the canine heart . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
78,
87
]
} | {
"id": "C0001480",
"name": "adenosine triphosphate",
"pos": [
92,
114
]
} |
a closed chest canine model was used to study the electrophysiologic effects of adenosine and adenosine triphosphate ( atp ) on the sino-atrial ( sa ) and atrioventricular ( av ) nodes . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
80,
89
]
} | {
"id": "C0001480",
"name": "adenosine triphosphate",
"pos": [
94,
116
]
} |
exogenous adenosine and atp , when rapidly administered into the right atrium , caused transient negative chronotropic and dromotropic effects on the sa and av nodes , respectively . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
10,
19
]
} | {
"id": "C0001480",
"name": "atp",
"pos": [
24,
27
]
} |
physostigmine enhanced the chronotropic effects of adenosine and atp and the dromotropic effects of atp . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
51,
60
]
} | {
"id": "C0001480",
"name": "atp",
"pos": [
100,
103
]
} |
atropine abolished the enhancement of the electrophysiologic effects of adenosine and atp caused by physostigmine . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
72,
81
]
} | {
"id": "C0001480",
"name": "atp",
"pos": [
86,
89
]
} |
the greater potency of isoxuprine and nylidrin in inhibiting alpha 1-adrenoreceptors than binding to beta 2-adrenoreceptors or causing nonspecific relaxation suggest that alpha-adrenoreceptor antagonist actions of these drugs may be important in their ability to inhibit smooth muscle tone . | NA | {
"id": "C0001638",
"name": "alpha 1-adrenoreceptors",
"pos": [
61,
84
]
} | {
"id": "C0034784",
"name": "alpha-adrenoreceptor",
"pos": [
171,
191
]
} |
poly ( epsilon-caprolactone ) [ pec ] , a biodegradable aliphatic polyester , undergoes a two-stage degradation process : the first lengthy phase involves nonenzymatic hydrolytic cleavage of ester groups , the second phase beginning when the polymer is more highly crystalline , and of low molecular weight . | NA | {
"id": "C0032474",
"name": "polyester",
"pos": [
66,
75
]
} | {
"id": "C0032521",
"name": "polymer",
"pos": [
242,
249
]
} |
the properties of the `` '' native '' '' and `` '' magnetic '' '' sephadexes as carriers for protein immobilization were compared by parallel immobilization on both carriers of alpha-chymotrypsin and 131i-albumin . | NA | {
"id": "C0033684",
"name": "for pro",
"pos": [
89,
96
]
} | {
"id": "C0001924",
"name": "31i-alb",
"pos": [
201,
208
]
} |
we prepared monoclonal antibodies specific for fast or slow classes of myosin heavy chain isoforms in the chicken and used them to probe myosin expression in cultures of myotubes derived from embryonic chicken myoblasts . | NA | {
"id": "C0027100",
"name": "myosin",
"pos": [
71,
77
]
} | {
"id": "C0027096",
"name": "myosin",
"pos": [
137,
143
]
} |
myosin heavy chain expression was assayed by gel electrophoresis and immunoblotting of extracted myosin and by immunostaining of cultures of myotubes . | NA | {
"id": "C0027100",
"name": "myosin heavy",
"pos": [
0,
12
]
} | {
"id": "C0027096",
"name": "myosin",
"pos": [
97,
103
]
} |
using the technique of flow cytometry to examine the large number of nonreplicating fibroblasts in confluent cultures , we have found that statin is mostly expressed in those cells showing the least amount of dna content , whose growth is blocked at the g0/g1 stage of the cell cycle . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
84,
95
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
175,
180
]
} |
when rous sarcoma virus-transformed chick embryo fibroblasts are cultured on the ecm in the presence of the tumor promoter tetradecanoyl phorbol acetate , the transformed cells lose their characteristic rounded morphology and align on and within the ecm fibrillar network . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
49,
60
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
171,
176
]
} |
localization of cytoplasmic dynein atpase in the mitotic spindle was investigated by electron microscopic immunocytochemistry with a monoclonal antibody ( d57 ) against sea urchin sperm flagellar 21s dynein and colloidal gold-labeled second antibody . | NA | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
133,
152
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
241,
249
]
} |
electrophoretic and immunoelectrophoretic analysis indicates that , like the tetraselmis protein , the chlamydomonas antigen consists of two acidic isoforms of approximately 20 kd . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
89,
96
]
} | {
"id": "C0597298",
"name": "isoforms",
"pos": [
148,
156
]
} |
we studied the effect of sodium butyrate , a potent g1/g2-arresting agent , on actin distribution in rat 3y1 fibroblasts in monolayer culture by fluorescence microscopy of cells stained with 7-nitrobenz-2-oxa-1 , 3-diazole phallacidine ( nbd-ph ) . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
109,
120
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
172,
177
]
} |
myoblast-conditioned medium contained significantly more sm-c [ 1,609 +/- 953 mu/mg cell protein ( mean +/- sd ) ; n = 10 ] than did that conditioned by fibroblasts ( 637 +/- 323 ; n = 5 ; p less than 0.02 ) . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
84,
88
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
153,
164
]
} |
separation of ascorbic acid , dehydroascorbic acid , diketogulonic acid and glucose by isocratic elution from a column of a hydrophilic gel . | NA | {
"id": "C0003968",
"name": "ascorbic acid",
"pos": [
14,
27
]
} | {
"id": "C0011177",
"name": "dehydroascorbic acid",
"pos": [
30,
50
]
} |
high-performance liquid chromatography on an asahipak gs-320 hydrophilic gel column with tartrate buffer ( 0.015 m , ph 3.0 ) containing 2 mm ethylenediaminetetraacetate and 0.05 % beta-thiodiglycol as the eluent allowed the separation of glucose , diketogulonic acid , dehydroascorbic acid and ascorbic acid within 30 m... | NA | {
"id": "C0011177",
"name": "dehydroascorbic acid",
"pos": [
270,
290
]
} | {
"id": "C0003968",
"name": "ascorbic",
"pos": [
295,
303
]
} |
fluorimetric monitoring of these compounds in the eluate with benzamidine at alkaline ph and at 90 degrees c in the presence of potassium sulphite allowed the determination of nanogram amounts of ascorbic acid , dehydroascorbic acid and diketogulonic acid . | NA | {
"id": "C0003968",
"name": "ascorbic acid",
"pos": [
196,
209
]
} | {
"id": "C0011177",
"name": "dehydroascorbic acid",
"pos": [
212,
232
]
} |
determination of dopamine-3- and 4-o-sulphate in human plasma and urine by anion-exchange high-performance liquid chromatography with fluorimetric detection . | NA | {
"id": "C0038720",
"name": "sulphate",
"pos": [
37,
45
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
75,
80
]
} |
a high-performance liquid chromatographic ( hplc ) method is reported for the determination of dopamine-3- and -4-o-sulphate isomers in human plasma and urine using an anion exchanger coupled with post-column hydrolysis and fluorimetric detection . | NA | {
"id": "C0038720",
"name": "sulphate",
"pos": [
116,
124
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
168,
173
]
} |
the determination of pyridoxal-5-phosphate ( plp ) and pyridoxal ( pl ) in plasma requires the availability of dark room facilities , due to the photosensitivity of these vitamin b6 vitamers . | NA | {
"id": "C0034263",
"name": "pyridoxal",
"pos": [
21,
30
]
} | {
"id": "C0087162",
"name": "vitamin b6",
"pos": [
171,
181
]
} |
the pas-elisa method was more sensitive than the direct double antibody sandwich form of elisa ( das-elisa ) , e.g . not only were a405 values for homologous reactions greater in pas-elisa but also an antiserum to a birch isolate of cherry leaf roll virus detected four related isolates with the new method against only ... | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
201,
210
]
} | {
"id": "C0003241",
"name": "das-elisa",
"pos": [
329,
338
]
} |
since the liquid-phase elisa will detect antibody/antigen reactions which are of direct relevance to the protective immune response in vivo ( opsonisation ; neutralisation of pathogen infectivity ) , it is recommended that this assay should be used to characterise the antibody reactivity of antisera and hybridoma cultu... | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
41,
49
]
} | {
"id": "C0020960",
"name": "antisera",
"pos": [
292,
300
]
} |
these results indicate that d can induce a significant decline in plasma levels of acth , beta-lipotropin , and beta-endorphin , the major circulating peptides from the c-terminal part of proopiocortin , and suggest that opioid peptides may be involved in the control of the functional activity of pituitary-adrenocortic... | NA | {
"id": "C0023832",
"name": "beta-lipotropin",
"pos": [
90,
105
]
} | {
"id": "C0033195",
"name": "proopiocortin",
"pos": [
188,
201
]
} |
taken together with previous published results , our measurements suggest a generalized metabolic defect in leprechaun fibroblasts that can only partly be explained by the reduced sensitivity of the cells to insulin . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
119,
130
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
199,
204
]
} |
plasma aldosterone , 18-hydroxycorticosterone , corticosterone , 18-hydroxy-11-deoxycorticosterone , and cortisol were measured in plasma sampled at the end of each rate of infusion in both groups . | NA | {
"id": "C0000172",
"name": "18-hydroxycorticosterone",
"pos": [
21,
45
]
} | {
"id": "C0010124",
"name": "corticosterone",
"pos": [
84,
98
]
} |
when leu 3+ cells from patients with high proportions of such nk-like cells ( or leu 3+-leu 15+ cells from selected patients ) were isolated with a fluorescence-activated cell sorter , these cells did not proliferate in response to allogeneic cells or t-cell mitogens , nor did they provide help for b-cell differentiati... | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
12,
17
]
} | {
"id": "C3485979",
"name": "allogeneic cells",
"pos": [
232,
248
]
} |
in contrast , the other two biotypes had a high incidence of clindamycin , gentamicin , and kanamycin resistance and neomycin susceptibility and accounted for most of the very major discrepancies in the clindamycin and aminoglycoside tests . | NA | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
75,
85
]
} | {
"id": "C0002556",
"name": "aminoglycoside",
"pos": [
219,
233
]
} |
in contrast , the other two biotypes had a high incidence of clindamycin , gentamicin , and kanamycin resistance and neomycin susceptibility and accounted for most of the very major discrepancies in the clindamycin and aminoglycoside tests . | NA | {
"id": "C0027603",
"name": "neomycin",
"pos": [
117,
125
]
} | {
"id": "C0002556",
"name": "aminoglycoside",
"pos": [
219,
233
]
} |
voltage-gated potassium channels resembling delayed rectifier potassium channels in excitable cells are present in most t-lymphocytes , t-lymphocyte-derived cell lines and macrophages . | NA | {
"id": "C0814023",
"name": "voltage-gated potassium channels",
"pos": [
0,
32
]
} | {
"id": "C0259540",
"name": "delayed",
"pos": [
44,
51
]
} |
this toxin effect was selective for the receptor agonist , since stimulation of these parameters by two substances bypassing the transduction mechanism , the calcium ionophore ionomycin and the phorbolester phorbol myristate acetate , were unaffected . | NA | {
"id": "C0031586",
"name": "phorbolester",
"pos": [
194,
206
]
} | {
"id": "C0039654",
"name": "phorbol myristate acetate",
"pos": [
207,
232
]
} |
extraction of glomerular hete by alkaline hydrolysis , to evaluate possible reacylation of hete after their production , confirmed the presence of 12-hete and did not provide evidence of 5-hete synthesis . | NA | {
"id": "C0044800",
"name": "12-hete",
"pos": [
147,
154
]
} | {
"id": "C0020349",
"name": "hete",
"pos": [
189,
193
]
} |
the enhanced glomerular 12-hete synthesis commenced as early as 3-5 h after administration of nephrotoxic serum and peaked at day 2 with 10-fold enhancement of 12-hete production . | NA | {
"id": "C0044800",
"name": "12-hete",
"pos": [
24,
31
]
} | {
"id": "C0020349",
"name": "hete",
"pos": [
163,
167
]
} |
since a complete map of insulin-related peptides in humans requires consideration of proinsulin , arg32/glu33-split proinsulin , arg65/gly66-split proinsulin , des-arg31 , arg32-proinsulin , des-lys64 , arg65-proinsulin , and insulin , we applied high performance liquid chromatography coupled with radioimmunoassay to i... | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
24,
31
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
348,
358
]
} |
kinetic analysis of proinsulin processing by a mixture of trypsin and carboxypeptidase b ( to stimulate in vivo processes ) revealed ( a ) a rapid decline in proinsulin concommitant with formation of conversion intermediates , ( b ) formation of des-arg31 , arg32-proinsulin and des-lys64 , arg65-proinsulin in the ratio... | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
20,
30
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
395,
402
]
} |
we conclude that ( a ) processing of proinsulin to insulin in vivo as in vitro likely occurs by preferential cleavage at the arg32-glu33 peptide bond in proinsulin , ( b ) proinsulin is inefficiently processed in the vascular compartment , and ( c ) subcutaneous administration of the precursor can result in the formati... | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
40,
47
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
172,
182
]
} |
patients with autoimmune diseases , such as systemic lupus erythematosus , rheumatoid arthritis , and sjogren 's syndrome , and paracoccidioidomycosis were found to contain immune complexes bearing c3b/ic3b or c3d . | NA | {
"id": "C0004364",
"name": "autoimmune diseases",
"pos": [
14,
33
]
} | {
"id": "C0024141",
"name": "systemic lupus",
"pos": [
44,
58
]
} |
patients with autoimmune diseases , such as systemic lupus erythematosus , rheumatoid arthritis , and sjogren 's syndrome , and paracoccidioidomycosis were found to contain immune complexes bearing c3b/ic3b or c3d . | NA | {
"id": "C0003873",
"name": "rheumatoid arthritis",
"pos": [
75,
95
]
} | {
"id": "C1527336",
"name": "sjogren 's syndrome",
"pos": [
102,
121
]
} |
factor b and c2 are structurally and functionally similar complement proteins encoded by genes that are closely linked within the class iii region of the major histocompatibility complex ( mhc ) . | NA | {
"id": "C0033453",
"name": "factor b",
"pos": [
0,
8
]
} | {
"id": "C0009498",
"name": "complement proteins",
"pos": [
58,
77
]
} |
in hemochromatosis and other disorders associated with iron overload , a significant fraction of the total iron in plasma circulates in the form of low molecular weight complexes not bound to transferrin . | NA | {
"id": "C0018995",
"name": "hemochromatosis",
"pos": [
3,
18
]
} | {
"id": "C0282193",
"name": "iron overload",
"pos": [
55,
68
]
} |
we studied the incorporation and metabolism of eicosapentanoic ( epa ) and docosahexaenoic acid in six human volunteers who supplemented their normal western diet for 5 mo daily with 10-40 ml of cod liver oil , rich in omega-3 polyunsaturated fatty acids . | NA | {
"id": "C0012968",
"name": "docosahexaenoic acid",
"pos": [
75,
95
]
} | {
"id": "C0015689",
"name": "omega-3",
"pos": [
219,
226
]
} |
however , since giardia has no capacity to synthesize membrane lipid , biliary lecithin may be a major source of phospholipid for growth of this parasite . | NA | {
"id": "C0025249",
"name": "membrane lipid",
"pos": [
54,
68
]
} | {
"id": "C0031676",
"name": "phospholipid",
"pos": [
113,
125
]
} |
to identify the electrolyte transport pathways involved in the cl- secretory process , the effect of prostaglandin e1 on ion fluxes was tested in the presence of putative inhibitors . | NA | {
"id": "C0013832",
"name": "electrolyte",
"pos": [
16,
27
]
} | {
"id": "C0022023",
"name": "ion",
"pos": [
121,
124
]
} |
high levels of spontaneous iga-sc were observed in sle patients ( greater than 10 ( 2 ) cells/10 ( 4 ) peripheral blood mononuclear cells [ pbmc ] ) , whereas spontaneous igm- , igg- , or ige-sc were not proportionately increased . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
88,
93
]
} | {
"id": "C1321301",
"name": "peripheral blood mononuclear cells",
"pos": [
103,
137
]
} |
in contrast , spontaneous immunoglobulin- ( igm , igg , and iga ) sc were not observed in healthy volunteers ( less than 10 cells/10 ( 4 ) pbmc ) . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
124,
129
]
} | {
"id": "C1321301",
"name": "pbmc",
"pos": [
139,
143
]
} |
the pomc products were examined using a combination of gel exclusion chromatography and four different radioimmunoassays directed against gamma 3 melanocyte stimulating hormone ( gamma 3msh ) , acth , gamma-lipotropin ( gamma lph ) , and beta-endorphin . | NA | {
"id": "C0033195",
"name": "pomc",
"pos": [
4,
8
]
} | {
"id": "C0017046",
"name": "gamma-lipotropin",
"pos": [
201,
217
]
} |
to ascertain the potential importance of the interaction between the renal nerves and angiotensin ii in these circumstances , we compared the renal cortical hemodynamics in additional groups of water-deprived rats ( group 4 ) after dnx ( n = 15 ) , ( group 5 ) during inhibition of angiotensin ii with saralasin ( n = 15... | NA | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
86,
100
]
} | {
"id": "C0036193",
"name": "saralasin",
"pos": [
368,
377
]
} |
the high-charge fraction contains three major proteins and several minor proteins associated with the glycosaminoglycans by both lectin-type and ionic bonding . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
46,
54
]
} | {
"id": "C0023206",
"name": "lectin",
"pos": [
129,
135
]
} |
a small group of npy-immunoreactive cell bodies is present in the lateral habenula and a moderate number of npy-immunoreactive fibers occurs in periaqueductal gray and nucleus raphe pallidus . | NA | {
"id": "C0027895",
"name": "npy",
"pos": [
17,
20
]
} | {
"id": "C0027893",
"name": "npy",
"pos": [
108,
111
]
} |
we studied afferents to the parabrachial nucleus ( pb ) from the spinal cord and the spinal trigeminal nucleus pars caudalis ( snvc ) in the rat by using the anterograde and retrograde transport of wheat germ agglutinin conjugated to horseradish peroxidase ( wga-hrp ) . | NA | {
"id": "C0019941",
"name": "horseradish peroxidase",
"pos": [
234,
256
]
} | {
"id": "C0078473",
"name": "wga-hrp",
"pos": [
259,
266
]
} |
this was observed in lipid containing tumors , malignant melanomas , tumors containing hemorrhage , acoustic neuromas , meningiomas , hamartomas , a pituitary prolactinoma , astrocytomas ( grade i ) treated with radiotherapy , pediatric tumors , and cases of unknown cause . | NA | {
"id": "C0027651",
"name": "tumors",
"pos": [
38,
44
]
} | {
"id": "C0018552",
"name": "hamartomas",
"pos": [
134,
144
]
} |
it is concluded that subjects with occupational asthma caused by various agents can remain symptomatic of asthma and demonstrate a persistence of bronchial obstruction and hyperexcitability for prolonged intervals after cessation of exposure . | NA | {
"id": "C0264423",
"name": "occupational asthma",
"pos": [
35,
54
]
} | {
"id": "C0004096",
"name": "asthma",
"pos": [
106,
112
]
} |
significant decreases were seen in fasting cholesterol ( p less than .05 ) , but the decreases seemed to result largely from the significant reductions in high-density lipoprotein cholesterol . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
43,
54
]
} | {
"id": "C0023822",
"name": "high-density lipoprotein cholesterol",
"pos": [
155,
191
]
} |
fumes generated from mild steel and stainless steel welding were collected on paper filters and tested in the bhk and she cell transformation assays . | NA | {
"id": "C0038239",
"name": "steel",
"pos": [
26,
31
]
} | {
"id": "C0038126",
"name": "stainless steel",
"pos": [
36,
51
]
} |
acute toxic inhalation by the oxidant gases , particularly ozone ( o3 ) , nitrogen dioxide ( no2 ) and oxygen ( o2 ) at high tension , has been assumed to be no more than a chemical burn of the epithelial surface . | NA | {
"id": "C0030106",
"name": "o3",
"pos": [
67,
69
]
} | {
"id": "C0030054",
"name": "o2",
"pos": [
112,
114
]
} |
simultaneous constant infusions of [ 9,10 ( 3 ) h ] palmitic acid and [ 1-14c ] palmitic acid ( 3 animals ) or [ 9,10 ( 3 ) h ] and [ 6-14c ] palmitic acids ( 3 animals ) or [ 9,10 ( 3 ) h ] and universal [ 14c ] palmitic acids ( 3 animals ) were given to the mothers and blood samples and perfusion fluid collected over... | NA | {
"id": "C0030234",
"name": "palmitic acid",
"pos": [
52,
65
]
} | {
"id": "C0030235",
"name": "palmitic acids",
"pos": [
213,
227
]
} |
as part of the british gallstone study group 's multi-centre post-dissolution trial of different treatment regimes designed to prevent recurrence after complete gallstone dissolution , the frequency of concordance and discordance between oral cholecystography ( ocg ) and ultrasonography ( u/s ) , and between repeat u/s... | NA | {
"id": "C0008350",
"name": "gallstone",
"pos": [
23,
32
]
} | {
"id": "C0006736",
"name": "stones",
"pos": [
355,
361
]
} |
during 6-24 months follow-up , from a total of 129 u/s examinations , gallstone recurrence was detected on 25 occasions ( 19 definite and 6 probable ) in 14 patients , and from a total of 71 ocgs , recurrent stones were detected on 11 occasions in 10 patients . | NA | {
"id": "C0008350",
"name": "gallstone",
"pos": [
70,
79
]
} | {
"id": "C0006736",
"name": "stones",
"pos": [
208,
214
]
} |
these results show that following complete gallstone dissolution by bile acid treatment , there is both intra- and inter-technique variation in the detection of recurrent stones . | NA | {
"id": "C0008350",
"name": "gallstone",
"pos": [
43,
52
]
} | {
"id": "C0006736",
"name": "stones",
"pos": [
171,
177
]
} |
mouse secretory ameloblasts express a number of enamel proteins , which have been divided into amelogenin and enamelin subfamilies . | NA | {
"id": "C0011353",
"name": "enamel proteins",
"pos": [
48,
63
]
} | {
"id": "C0051560",
"name": "amelogenin",
"pos": [
95,
105
]
} |
we have used polyclonal antibodies to murine amelogenins to reveal enamel proteins in mouse ameloblasts using the protein a-gold immunocytochemical technique . | NA | {
"id": "C0051560",
"name": "amelogenins",
"pos": [
45,
56
]
} | {
"id": "C0011353",
"name": "enamel proteins",
"pos": [
67,
82
]
} |
during the first month of the study the overall incidence of infection was 8.2 % , the incidence of postoperative wound infection was 3.8 % , urinary tract infection 3.2 % , lower respiratory tract infection 1.2 % and bacteraemia 0.6 % . | NA | {
"id": "C0009450",
"name": "infection",
"pos": [
61,
70
]
} | {
"id": "C0042029",
"name": "urinary tract infection",
"pos": [
142,
165
]
} |
a two-site sandwich enzyme immunoassay for human chorionic gonadotropin ( hcg ) employing monoclonal antibodies directed against beta- and alpha-subunits is described . | NA | {
"id": "C0018062",
"name": "human chorionic gonadotropin",
"pos": [
43,
71
]
} | {
"id": "C0017963",
"name": "alpha-subunits",
"pos": [
139,
153
]
} |
rabbit antiserum , specific for protein a from staphylococcus aureus , was conjugated to alkaline phosphatase and used in a double antibody solid-phase enzyme immunoassay . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
7,
16
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
131,
139
]
} |
three purified monoclonal mouse antibodies were also tested which allowed use of the same preparation as a monoisotypic antibody standard or as a 'myeloma protein ' standard . | NA | {
"id": "C0003250",
"name": "monoclonal",
"pos": [
15,
25
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
120,
128
]
} |
through the combined use of an 131i-enzyme-antibody immune complex ( eic ) detection system and 125i-m315 , it was shown that the deviation from the linear binding of 125i-m315 observed during its indirect detection in the so-called linear region of the elisa titration curve was the result of changing ratios of bound e... | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
36,
42
]
} | {
"id": "C0026741",
"name": "eic",
"pos": [
319,
322
]
} |
through the combined use of an 131i-enzyme-antibody immune complex ( eic ) detection system and 125i-m315 , it was shown that the deviation from the linear binding of 125i-m315 observed during its indirect detection in the so-called linear region of the elisa titration curve was the result of changing ratios of bound e... | NA | {
"id": "C0003313",
"name": "immune complex",
"pos": [
52,
66
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
339,
347
]
} |
the antibodies did not cross-react with unpigmented cells , including k1735 amelanotic melanoma cells , albino murine skin or eye tissue , fibrosarcoma cells , rat fibroblasts , or epidermal keratinocytes . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
52,
57
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
164,
175
]
} |
the svk14 cell line developed by taylor-papadimitriou et al can serve as a model for study of the modification of various cellular processes by certain pharmacologic and physiologic agents , because these cells resemble normal keratinocytes with respect to a variety of parameters related to proliferation and differenti... | NA | {
"id": "C0022567",
"name": "variety",
"pos": [
259,
266
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
351,
356
]
} |
the absorbed lipid was extracted from the disks with ether and analyzed for wax esters by thin-layer chromatography . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
13,
18
]
} | {
"id": "C0043076",
"name": "wax",
"pos": [
76,
79
]
} |
no evidence has been found that would indicate that huifn-beta 1 mrna induced in namalva cells is different from that induced in human fibroblasts . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
89,
94
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
135,
146
]
} |
the pharmacokinetics of plasma plp clearance were measured in these subjects before and after 4 weeks of intravenous pn supplementation ( 122 mumol/day ) . | NA | {
"id": "C0034266",
"name": "plp",
"pos": [
31,
34
]
} | {
"id": "C0034272",
"name": "supplementation",
"pos": [
120,
135
]
} |
the immersion of a limb in a mixture of water and ice induces in normal humans an initial vasoconstriction mediated mainly by catecholamine release . | NA | {
"id": "C0043047",
"name": "water",
"pos": [
40,
45
]
} | {
"id": "C0020746",
"name": "ice",
"pos": [
50,
53
]
} |
na-k-adenosine triphosphatase ( atpase ) activity was determined in individual nephron segments obtained from the kidneys of euthyroid and hypothyroid rats . | NA | {
"id": "C0001479",
"name": "na-k-adenosine triphosphatase",
"pos": [
0,
29
]
} | {
"id": "C0001473",
"name": "atpase",
"pos": [
32,
38
]
} |
in 76 per cent of multiple primary tumours , the second or third tumour was the cause of death . | NA | {
"id": "C0027663",
"name": "multiple primary tumours",
"pos": [
18,
42
]
} | {
"id": "C0027651",
"name": "tumour",
"pos": [
65,
71
]
} |
during exercise under a load of 50 or 100 watts , the increases in adrenaline , noradrenaline and dopamine concentrations were greatest in patients with alcoholic cirrhosis . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
67,
77
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
80,
93
]
} |
fifth-grade children demonstrated no effect for gender and their path preferences resembled those of adult males . | NA | {
"id": "C0079399",
"name": "gender",
"pos": [
48,
54
]
} | {
"id": "C0086582",
"name": "males",
"pos": [
107,
112
]
} |
the alpha 2-macroglobulins are large molecular weight proteinase-binding proteins that inhibit the ability of proteinases to hydrolyze protein substrates without suppressing activity against amide or ester substrates . | NA | {
"id": "C0030946",
"name": "proteinase",
"pos": [
54,
64
]
} | {
"id": "C0030940",
"name": "proteinases",
"pos": [
110,
121
]
} |
the currents through voltage-activated calcium channels in heart cell membranes are suppressed by dihydropyridine calcium antagonists such as nifedipine . | NA | {
"id": "C2945601",
"name": "dihydropyridine calcium antagonists",
"pos": [
98,
133
]
} | {
"id": "C0028066",
"name": "nifedipine",
"pos": [
142,
152
]
} |
values of vmax for glycerol , pyruvate and lactate were similar and approximately twice those for glucose , mannose , glucosamine and n-acetylglucosamine ; | NA | {
"id": "C0017718",
"name": "glucosamine",
"pos": [
118,
129
]
} | {
"id": "C0001056",
"name": "n-acetylglucosamine",
"pos": [
134,
153
]
} |
in cells grown on complex medium in which glucose was replaced by mannose , glucosamine or n-acetylglucosamine , vmax and km for the respective growth sugars and for glucose were not significantly affected . | NA | {
"id": "C0017718",
"name": "glucosamine",
"pos": [
76,
87
]
} | {
"id": "C0001056",
"name": "n-acetylglucosamine",
"pos": [
91,
110
]
} |
it seems likely that the karyophilic nature of m and ns1 , unlike that of np , is a property not of the proteins themselves , but of a complex which they form with some other product of the infected cell . | NA | {
"id": "C0028612",
"name": "np",
"pos": [
74,
76
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
104,
112
]
} |
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