text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
changes in ornithine decarboxylase [ ec 4.1.1.17 ] activity and the tissue levels of polyamines in liver remnants showed similar patterns in normal and 5-azacytidine-pretreated rats , except that the putrescine level in removed liver and the spermidine level in the s-phase were significantly higher in the drug-pretreat... | NA | {
"id": "C0034170",
"name": "putrescine",
"pos": [
200,
210
]
} | {
"id": "C0037871",
"name": "level",
"pos": [
253,
258
]
} |
the precision , reproducibility and sensitivity of the quantitation of cholesterol with this method were acceptable , and the values of hdl-cholesterol determined by this method correlated well with those found by the heparin-manganese chloride precipitation method ( r=0.958 , n=93 ) . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
71,
82
]
} | {
"id": "C0023822",
"name": "hdl-cholesterol",
"pos": [
136,
151
]
} |
both particulate and cytosol catalases from porcine kidney were purified by ammonium sulfate fractionation followed by deae-cellulose , cm-cellulose , and sephadex g-100 column chromatographies . | NA | {
"id": "C0011050",
"name": "deae-cellulose",
"pos": [
119,
133
]
} | {
"id": "C0007648",
"name": "cellulose",
"pos": [
139,
148
]
} |
fatty acid spin labels were used to probe the bulk membrane lipids while long-chain spin labels attached at one end to the ca2+-atpase molecules through a covalent bond were used to monitor the boundary lipids . | NA | {
"id": "C0025249",
"name": "membrane lipids",
"pos": [
51,
66
]
} | {
"id": "C0023779",
"name": "lipids",
"pos": [
203,
209
]
} |
the enzyme f delta transcribed b. subtilis dna about 1.6 times more actively than enzyme f sigma , and the enzymes m sigma and f sigma transcribed the dna about 2.2 times more actively than did core enzyme . | NA | {
"id": "C0919262",
"name": "b",
"pos": [
27,
28
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
151,
154
]
} |
using the same technique , it was shown that kinin- and fragment 1.2-free protein forms a complex not only with prekallikrein but also with kallikrein . | NA | {
"id": "C0033024",
"name": "prekallikrein",
"pos": [
112,
125
]
} | {
"id": "C0022478",
"name": "kallikrein",
"pos": [
140,
150
]
} |
analyses of subunit proteins by sds-polyacrylamide slab gel electrophoresis showed that these pyocins were composed of 5 major ( bands 1 , 2 , 3 , 4 , and 6 ) and 2 minor ( bands 5 and 7 ) subunit proteins and that no difference in the mobilities of these subunit proteins could be detected among the pyocins except that... | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
20,
28
]
} | {
"id": "C0599220",
"name": "subunit protein",
"pos": [
341,
356
]
} |
the results indicate that , among viruses sharing the same serotype determined by the surface proteins ha and na ( neuraminidase ) , considerable variations exist in the structure of viral proteins , including inner proteins . | NA | {
"id": "C0025252",
"name": "surface",
"pos": [
86,
93
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
216,
224
]
} |
in tfm mice , t3 also increased all these isozymes except the pi-4.6 hydrolytic activity for baee , but 5 alpha-dht had no effect on any enzymes . | NA | {
"id": "C0022173",
"name": "isozymes",
"pos": [
42,
50
]
} | {
"id": "C0014442",
"name": "enzymes",
"pos": [
137,
144
]
} |
lithocholic acid , deoxycholic acid , chenodeoxycholic acid , ursodeoxycholic acid , and cholic acid were determined by monitoring the intensities of m/z 622 , m/z 620 , m/z 620 , m/z 620 , ad m/z 618 , respectively . | NA | {
"id": "C0011479",
"name": "deoxycholic acid",
"pos": [
19,
35
]
} | {
"id": "C0008024",
"name": "chenodeoxycholic acid",
"pos": [
38,
59
]
} |
lithocholic acid , deoxycholic acid , chenodeoxycholic acid , ursodeoxycholic acid , and cholic acid were determined by monitoring the intensities of m/z 622 , m/z 620 , m/z 620 , m/z 620 , ad m/z 618 , respectively . | NA | {
"id": "C0011479",
"name": "deoxycholic acid",
"pos": [
19,
35
]
} | {
"id": "C0042105",
"name": "ursodeoxycholic acid",
"pos": [
62,
82
]
} |
the atpase activity of purified coupling factor 1 ( cf1 ) of spinach chloroplasts [ ec 3.6.1.3 ] was reversibly enhanced in some aqueous organic solvents , notably methanol , ethanol , and acetone . | NA | {
"id": "C0001963",
"name": "methanol",
"pos": [
164,
172
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
175,
182
]
} |
assuming that 55 % of the total membrane protein is the ca2+ atpase , this is equivalent to 1 mol of sh/10 ( 5 ) g of atpase , designated as sh1-anm . | NA | {
"id": "C0001476",
"name": "ca2",
"pos": [
56,
59
]
} | {
"id": "C0001473",
"name": "atpase",
"pos": [
118,
124
]
} |
these results support the suggestion ( campbell , i. m. ( 1969 ) tetrahedron lett . 4777-4780 ) that the three-carbon unit of lawsone and , hence by inference , the four-carbon side chain of o-succinylbenzoic acid , is derived from the thiamin pyrophosphate adduct of succinic semialdehyde ( likely in the anion form ) . | NA | {
"id": "C0021966",
"name": "i",
"pos": [
33,
34
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
306,
311
]
} |
the transformed glucocorticoid . receptor complex is precipitated at 30 to 35 % ammonium sulfate , whereas the unoccupied receptor and the untransformed steroid-bound receptor are precipitated at 45 to 55 % of ammonium sulfate saturation . | NA | {
"id": "C0034809",
"name": "glucocorticoid",
"pos": [
16,
30
]
} | {
"id": "C0034840",
"name": "steroid",
"pos": [
153,
160
]
} |
reassociation of the modified alpha subunit with unmodified lh-beta or thyrotropin ( tsh ) -beta resulted in reconstituted hormones which differed markedly in their respective biological activities . | NA | {
"id": "C0040160",
"name": "thyrotropin",
"pos": [
71,
82
]
} | {
"id": "C0076641",
"name": "tsh",
"pos": [
85,
88
]
} |
reticulocyte membranes also display equal activities in response to ( - ) -isoproterenol in the presence of either gtp or gtp gamma s , whereas erythrocyte membrane adenylate cyclase is twice as active in the presence of isoproterenol plus gtp gamma s as in the presence of isoproterenol plus gtp . | NA | {
"id": "C0079469",
"name": "gtp gamma s",
"pos": [
122,
133
]
} | {
"id": "C0018353",
"name": "gtp",
"pos": [
293,
296
]
} |
however , the qualitative changes in responsiveness to hormones in the presence of gtp or gtp gamma s may be related to loss or proteolysis of the 52,000-dalton subunit of g/f . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
83,
86
]
} | {
"id": "C0079469",
"name": "gtp gamma s",
"pos": [
90,
101
]
} |
in addition , equilibrium dialysis experiments with 160tb3+ show that double helical polynucleotides ( which do not enhance tb3+ emission ) bind more cation/molar nucleotide residue than do single-stranded polynucleotides . | NA | {
"id": "C0028630",
"name": "nucleotide",
"pos": [
89,
99
]
} | {
"id": "C0032550",
"name": "polynucleotides",
"pos": [
206,
221
]
} |
no commensurate general inhibition of phosphorylation is seen in the non-histone nuclear proteins of butyrate-treated cells , but phosphorylation patterns are altered and 32p-uptake may be stimulated , as well as inhibited , depending upon the protein fraction analyzed . | NA | {
"id": "C0019652",
"name": "histone",
"pos": [
73,
80
]
} | {
"id": "C0028589",
"name": "nuclear proteins",
"pos": [
81,
97
]
} |
no commensurate general inhibition of phosphorylation is seen in the non-histone nuclear proteins of butyrate-treated cells , but phosphorylation patterns are altered and 32p-uptake may be stimulated , as well as inhibited , depending upon the protein fraction analyzed . | NA | {
"id": "C0028589",
"name": "nuclear proteins",
"pos": [
81,
97
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
244,
251
]
} |
a relatively fast conversion of procollagen v to p-collagen v is followed by slow change to collagen v . | NA | {
"id": "C0033235",
"name": "procollagen",
"pos": [
32,
43
]
} | {
"id": "C0009325",
"name": "collagen",
"pos": [
92,
100
]
} |
direct incubation of hdl3 or human serum with 3h-glycosphingolipid dispersions did not yield a glycolipid . hdl3 complex as judged by density gradient ultracentrifugation and sepharose cl-6b chromatography . | NA | {
"id": "C0017978",
"name": "glycosphingolipid",
"pos": [
49,
66
]
} | {
"id": "C0017950",
"name": "glycolipid",
"pos": [
95,
105
]
} |
l1210 mouse leukemia cells were made cobalamin-deficient by propagation in a medium from which cyanocobalamin was omitted and fetal bovine serum ( containing protein-bound cobalamins ) was replaced by bovine serum albumin . | NA | {
"id": "C0042845",
"name": "cyanocobalamin",
"pos": [
95,
109
]
} | {
"id": "C0086024",
"name": "cobalamins",
"pos": [
172,
182
]
} |
r1 , a basic protein having a ratio of basic/acidic amino acids of 2.0 and 20 mol % lysine , is distinguished from any chromosomal proteins characterized so far on the basis of electrophoretic mobility and amino acid composition . | NA | {
"id": "C0301714",
"name": "basic",
"pos": [
7,
12
]
} | {
"id": "C0024337",
"name": "lysine",
"pos": [
84,
90
]
} |
r1 , a basic protein having a ratio of basic/acidic amino acids of 2.0 and 20 mol % lysine , is distinguished from any chromosomal proteins characterized so far on the basis of electrophoretic mobility and amino acid composition . | NA | {
"id": "C0301714",
"name": "basic",
"pos": [
7,
12
]
} | {
"id": "C0002520",
"name": "amino acid",
"pos": [
206,
216
]
} |
the map location of ribonucleotides at the light strand origin of replication has been refined to a triplet nucleotide ( 5'-cgg-3 ' ) in the light strand initiation region . | NA | {
"id": "C0035548",
"name": "ribonucleotides",
"pos": [
20,
35
]
} | {
"id": "C0028630",
"name": "nucleotide",
"pos": [
108,
118
]
} |
antibodies raised against purified protein i have been isolated from rabbit antiserum by affinity chromatography on protein i-conjugated agarose column . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
0,
10
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
76,
85
]
} |
amino acid analyses of the na [ 3h ] bh4 reduction products obtained from membranes containing phosphorylated and dephosphorylated atpase identified [ 3h ] homoserine , the expected reduction product of beta-aspartyl phosphate , as the only additional tritiated reduction product in the samples from phosphorylated membr... | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
0,
10
]
} | {
"id": "C0019892",
"name": "homoserine",
"pos": [
156,
166
]
} |
these results indicate that the phosphorylated intermediate of the neurospora plasma membrane atpase is a beta-aspartyl phosphate identical with that already known to exist in the na+ : k+- and ca2+-translocating atpases of animal cell origin . | NA | {
"id": "C0001473",
"name": "atpase",
"pos": [
94,
100
]
} | {
"id": "C0001476",
"name": "ca2",
"pos": [
194,
197
]
} |
amino acid analysis revealed a high content of serine and glycine which together constitute 37 % of the amino acids . | NA | {
"id": "C0017890",
"name": "glycine",
"pos": [
58,
65
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
104,
115
]
} |
in contrast , at 20 mm mgcl2 , the rate of appearance of reconstituted activity was insensitive to concentrations of gmp-p ( nh ) p , cyc- membrane protein , and untreated cholate extract protein , but became sensitive to cholate extract protein concentration after treatment with gmp-p ( nh ) p and mg ion . | NA | {
"id": "C0025252",
"name": "membrane protein",
"pos": [
139,
155
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
238,
245
]
} |
amino acid analyses indicate that bromoperoxidase is rich in aspartic and glutamic acid residues , while being deficient in basic amino acid residues . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
0,
10
]
} | {
"id": "C0301714",
"name": "basic",
"pos": [
124,
129
]
} |
also , when used alone , cordycepin selectively slows the synthesis of those early proteins that can be induced by dexamethasone , suggesting that the mrnas coding for the early induced proteins have unusually short half-lives . | NA | {
"id": "C0034861",
"name": "synthesis",
"pos": [
58,
67
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
186,
194
]
} |
examination of sectioned , embedded material showed that almost all intermediate filaments normally present in cultured chick embryo fibroblasts , imr-33 cells , and bhk-21 cells were eliminated by trypsinization . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
133,
144
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
173,
178
]
} |
by double imminofluorescence labeling , the distribution of vimentin has been compared with that of subunit proteins of other types of intermediate filaments ( glial fibrillary acidic [ gfa ] protein , neurofilament protein , prekeratin ) and other cell-type specific markers ( fibronectin , tetanus toxin receptor , 04 ... | NA | {
"id": "C0021769",
"name": "proteins",
"pos": [
108,
116
]
} | {
"id": "C0017626",
"name": "glial fibrillary acidic",
"pos": [
160,
183
]
} |
by double imminofluorescence labeling , the distribution of vimentin has been compared with that of subunit proteins of other types of intermediate filaments ( glial fibrillary acidic [ gfa ] protein , neurofilament protein , prekeratin ) and other cell-type specific markers ( fibronectin , tetanus toxin receptor , 04 ... | NA | {
"id": "C0021769",
"name": "proteins",
"pos": [
108,
116
]
} | {
"id": "C0085418",
"name": "neurofilament protein",
"pos": [
202,
223
]
} |
in adult brain tissue , vimentin is found not only in fibroblasts and cells of larger blood vessels but also in ependymal cells and astrocytes . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
54,
65
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
122,
127
]
} |
however , those cells that had not adhered tightly and not formed a monolayer epithelium with typical polygonal cellular pattern contracted independently as observed in the glycerinated fibroblasts . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
16,
21
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
186,
197
]
} |
using the depurination method , we showed that macronuclear dna contained this sequence even after rdna had been removed . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
60,
63
]
} | {
"id": "C0012933",
"name": "rdna",
"pos": [
99,
103
]
} |
approximately 85 % of the total proteoglycans were susceptible to nitrous acid oxidation ( which degrades heparan sulfates ) , and approximately 15 % were susceptible to digestion with chondroitinase abc ( degrades chondroitin-4 and -6 sulfates and dermatan sulfate ) . | NA | {
"id": "C0008454",
"name": "chondroitin",
"pos": [
185,
196
]
} | {
"id": "C0011602",
"name": "dermatan",
"pos": [
249,
257
]
} |
density gradient centrifugation resulted in the partial separation of the extracted proteoglycans into two types with different densities : a heparan sulfate proteoglycan that was enriched in the heavier fraction ( p greater than 1.43 g/ml ) , and a chondroitin sulfate proteoglycan that was concentrated in the lighter ... | NA | {
"id": "C0033692",
"name": "proteoglycans",
"pos": [
84,
97
]
} | {
"id": "C0033689",
"name": "chondroitin sulfate proteoglycan",
"pos": [
250,
282
]
} |
the chromatographic behavior of the extracted proteoglycans and the derived gag , together with the fact that the two types of proteoglycans can be partially separated into the density gradient , suggest that the heparan sulfate and chondroitin sulfate ( s ) are located on different core proteins . | NA | {
"id": "C0017973",
"name": "gag",
"pos": [
76,
79
]
} | {
"id": "C0019143",
"name": "heparan sulfate",
"pos": [
213,
228
]
} |
the unchanged distribution of a permeant anion , chloride , argues against the existence of a large and sustained transsr potential during tetanus , if the chloride permeability of the in situ sr is as high as suggested by measurements on fractionated sr . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
41,
46
]
} | {
"id": "C0008203",
"name": "chloride",
"pos": [
156,
164
]
} |
the distribution pattern is the same when glutaraldehyde fixation precedes the administration of the tracer by perfusion , provided fixation is followed by quenching of residual free aldehyde groups . | NA | {
"id": "C0017814",
"name": "glutaraldehyde",
"pos": [
42,
56
]
} | {
"id": "C0001992",
"name": "aldehyde",
"pos": [
183,
191
]
} |
fodrin ( formerly designated 26 and 27 ) comprises two polypeptides ( 250,000 and 240,000 mol wt ) that are axonally transported at a maximum time-averaged velocity of 40 mm/d -- slower than the most rapidly moving axonally transported proteins , but faster than at least three additional groups of proteins . | NA | {
"id": "C0007292",
"name": "transported",
"pos": [
117,
128
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
299,
307
]
} |
we found that virtually no cultured epidermal keratinocytes with a diameter less than or equal to 14 micrometer contained involucrin , but most cells greater than 17 micrometer did . | NA | {
"id": "C0022567",
"name": "diameter",
"pos": [
67,
75
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
144,
149
]
} |
addition of microtubule proteins prepared by cycles of assembly and disassembly resulted in phosphorylation of histone , phosphorylation of tubulin and the microtubule-associated proteins , and phosphorylation of neurofilament subunits . | NA | {
"id": "C0026042",
"name": "microtubule proteins",
"pos": [
12,
32
]
} | {
"id": "C0041348",
"name": "tubulin",
"pos": [
140,
147
]
} |
addition of microtubule proteins prepared by cycles of assembly and disassembly resulted in phosphorylation of histone , phosphorylation of tubulin and the microtubule-associated proteins , and phosphorylation of neurofilament subunits . | NA | {
"id": "C0026042",
"name": "microtubule proteins",
"pos": [
12,
32
]
} | {
"id": "C0026045",
"name": "microtubule-associated proteins",
"pos": [
156,
187
]
} |
past studies of norepinephrine-stimulated protein phosphorylation in intact c-6 glioma cells had identified a 58,000 molecular weight , 5.7 isoelectric point protein ( 58k-5.7 ) as a cyclic amp-dependent phosphoprotein and had shown that 58k-5.7 was one of the most abundant proteins of the nuclear fraction . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
42,
49
]
} | {
"id": "C0031689",
"name": "phosphoprotein",
"pos": [
204,
218
]
} |
past studies of norepinephrine-stimulated protein phosphorylation in intact c-6 glioma cells had identified a 58,000 molecular weight , 5.7 isoelectric point protein ( 58k-5.7 ) as a cyclic amp-dependent phosphoprotein and had shown that 58k-5.7 was one of the most abundant proteins of the nuclear fraction . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
42,
49
]
} | {
"id": "C0028589",
"name": "proteins",
"pos": [
275,
283
]
} |
the combination of deoxythymidine and deoxycytidine was much more effective than either deoxyribonucleoside used alone or than the combination of uridine and cytidine . | NA | {
"id": "C0011485",
"name": "deoxycytidine",
"pos": [
38,
51
]
} | {
"id": "C0010715",
"name": "cytidine",
"pos": [
158,
166
]
} |
effects of isometric exercise on plasma norepinephrine ( ne ) , epinephrine ( e ) , and related factors ( mean +/- se ) were studied in 10 healthy , insulin-dependent diabetic subjects and 10 matched control adults . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
40,
54
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
64,
75
]
} |
supraphysiological concentrations of t3 elicited a dose-related increase in fibroblast glucose consumption , which was similar in cells from both the patient and from a normal infant . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
76,
86
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
130,
135
]
} |
the 0800 h plasma concentrations of the mineralocorticoid hormones , 18-hydroxydeoxycorticosterone ( 18-ohdoc ) , deoxycorticosterone ( doc ) , corticosterone , 18-hydroxycorticosterone ( 18-ohb ) , and aldosterone , in six patients with nonsalt-losing congenital adrenal hyperplasia revealed two groupings of these ster... | NA | {
"id": "C0010124",
"name": "corticosterone",
"pos": [
84,
98
]
} | {
"id": "C0000172",
"name": "18-hydroxycorticosterone",
"pos": [
161,
185
]
} |
tetrodotoxin ( ttx ) , at concentrations that do not interfere with normal myogenesis or with myosin synthesis , causes of cultured muscle fibres to accumulate myosin heavy chain peptides . | NA | {
"id": "C0027096",
"name": "myosin",
"pos": [
94,
100
]
} | {
"id": "C0027100",
"name": "myosin heavy chain",
"pos": [
160,
178
]
} |
finally , limited proteolysis of myosin heavy chain isolated from ttx-treated and normal muscle fibres and display of cleavage products on sds-polyacrylamide gels does not reveal any significant difference between the two myosins . | NA | {
"id": "C0027100",
"name": "myosin heavy chain",
"pos": [
33,
51
]
} | {
"id": "C0027096",
"name": "myosins",
"pos": [
222,
229
]
} |
we suggest that trh , cyproheptadine , dopamine affect acth secretion in patients with acth-producing pituitary adenomas by their direct action on the adenoma . | NA | {
"id": "C1306214",
"name": "acth-producing pituitary adenomas",
"pos": [
87,
120
]
} | {
"id": "C0001430",
"name": "adenoma",
"pos": [
151,
158
]
} |
in the other two patients in group 2 , apo e-d was the predominant protein ( phenotype , apo e-d/d ) , but traces of protein in the region corresponding to normal apo e ( apo e-n ) were also present . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
67,
74
]
} | {
"id": "C0003601",
"name": "apo",
"pos": [
171,
174
]
} |
my3 and my4 are expressed by normal monocytes and by greater than 90 % of patients with acute monocytic leukemia or acute myelomonocytic leukemia , but are detected much less often on other types of myeloid leukemia . | NA | {
"id": "C0023479",
"name": "acute myelomonocytic leukemia",
"pos": [
116,
145
]
} | {
"id": "C0023470",
"name": "myeloid leukemia",
"pos": [
199,
215
]
} |
to determine whether old cells have a reduced response to a preparation of factors from human plasma with insulinlike activity ( ila ) , we analyzed the response to ila of early and late passage human fibroblasts from young , old , and progeric donors in the acute stimulation of [ 3h ] 2-deoxy-d-glucose ( 2dg ) uptake ... | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
25,
30
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
201,
212
]
} |
the release of lipoprotein lipase with heparin was not associated with a release of [ 3s ] glycosaminoglycans from 35s-prelabeled cells . | NA | {
"id": "C0019134",
"name": "heparin",
"pos": [
39,
46
]
} | {
"id": "C0017973",
"name": "glycosaminoglycans",
"pos": [
91,
109
]
} |
a method is described which enables the removal of antibodies and proinsulin from sera without affecting the c-peptide determination . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
66,
76
]
} | {
"id": "C0006558",
"name": "c-peptide",
"pos": [
109,
118
]
} |
furthermore , this method allows a semiquantitative estimation of proinsulin , provided there is enough cross reactivity of the c-peptide antibody with proinsulin . | NA | {
"id": "C0006558",
"name": "c-peptide",
"pos": [
128,
137
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
152,
162
]
} |
pruritic urticarial papules and plaques of pregnancy ( puppp ) was recently defined as an intensely pruritic cutaneous eruption occurring in the third trimester . | NA | {
"id": "C0032961",
"name": "pregnancy",
"pos": [
43,
52
]
} | {
"id": "C0032981",
"name": "third",
"pos": [
145,
150
]
} |
the development of a monoclonal antibody directed against hla dr ( ia-like ) antigens of b cells and monocytes but not against normal peripheral human t cells suggested that this antibody might be used as a marker of b cells and monocytes in tissue sections . | NA | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
21,
40
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
179,
187
]
} |
lennert 's lymphoma , or malignant lymphoma with a high content of epithelioid histiocytes , is an uncommon variant of non-hodgkin 's lymphoma . | NA | {
"id": "C0024299",
"name": "malignant lymphoma",
"pos": [
25,
43
]
} | {
"id": "C0024305",
"name": "non-hodgkin 's lymphoma",
"pos": [
119,
142
]
} |
this isoenzyme corresponded to the lower molecular weight isoenzyme of the two enzymes found in normal chicken skeletal muscle . | NA | {
"id": "C0022173",
"name": "isoenzyme",
"pos": [
5,
14
]
} | {
"id": "C0014442",
"name": "enzymes",
"pos": [
79,
86
]
} |
the dose-effect curves of gtp , p [ nh ] ppg , and gtp gamma s for inhibition of carbamylcholine binding ( measured by competition with [ 3h ] qnb ) and for adenylate cyclase activation ( measured in the presence of isoproterenol ) were parallel , at both 25 degrees c and 37 degrees c . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
26,
29
]
} | {
"id": "C0079469",
"name": "gtp",
"pos": [
51,
54
]
} |
skin testing showed a positive immediate skin test to the penicilloate minor determinant in the presence of negative tests to benzylpenicilloylpolylysine ( bpl ) and penicillin g ( pg ) , as well as cross-reactivity between the penicilloate derivatives of pg and cb . | NA | {
"id": "C0030827",
"name": "pg",
"pos": [
181,
183
]
} | {
"id": "C0006976",
"name": "cb",
"pos": [
263,
265
]
} |
epithelial cells , but not mesothelial cells , have been previously reported to contain sc , which may be involved in the intraepithelial transport of secretory iga . | NA | {
"id": "C0036538",
"name": "sc",
"pos": [
88,
90
]
} | {
"id": "C0020838",
"name": "secretory iga",
"pos": [
151,
164
]
} |
the method is based on the ability of cells treated with alloantiserum to ia and then with rabbit antiserum against the fc portion of chicken igg , to form rosettes with sheep erythrocytes ( srbc ) coated with chicken anti-srbc igg antibody . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
61,
70
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
232,
240
]
} |
tritium radiolabeling of antibodies to high specific activity with n-succinimidyl [ 2,3-3h ] propionate : use in detecting monoclonal antibodies . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
25,
35
]
} | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
123,
144
]
} |
the differences in reactivity between the two methods may depend on the presence of aggregated denatured actin in the antigen preparation used for immunization and exposure of the corresponding antigenic determinants of actin on the solid phase . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
118,
125
]
} | {
"id": "C0003316",
"name": "antigenic determinants",
"pos": [
194,
216
]
} |
this method can be used for rapidly screening blood samples from individuals of normal hemoglobin a genotype for the presence of rare anti-hemoglobin s and anti-hemoglobin c binding ghosts . | NA | {
"id": "C0019016",
"name": "hemoglobin a",
"pos": [
87,
99
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
161,
171
]
} |
comparison of the immunofluorescence assay with a radioimmunoassay using conventional antisera and hybridoma antibodies similar sensitivity for both assays . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
86,
94
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
109,
119
]
} |
antigen specific suppressor cell activity of peripheral blood mononuclear cells was investigated in 20 patients with psoriatic arthritis and 18 patients with uncomplicated psoriasis and compared to that of 27 age- and sex-matched healthy controls and 18 patients with osteoarthritis . | NA | {
"id": "C0003872",
"name": "psoriatic arthritis",
"pos": [
117,
136
]
} | {
"id": "C0033860",
"name": "psoriasis",
"pos": [
172,
181
]
} |
five of the 20 patients with psoriatic arthritis and 7 of the 18 patients with uncomplicated psoriasis demonstrated sca of more than 2 sd below the normal mean . | NA | {
"id": "C0003872",
"name": "psoriatic",
"pos": [
29,
38
]
} | {
"id": "C0033860",
"name": "psoriasis",
"pos": [
93,
102
]
} |
the plaque forming cell ( pfc ) response of patients with psoriatic arthritis and uncomplicated psoriasis was not different from those of the normal controls or of patients with osteoarthritis . | NA | {
"id": "C0003872",
"name": "psoriatic",
"pos": [
58,
67
]
} | {
"id": "C0033860",
"name": "psoriasis",
"pos": [
96,
105
]
} |
[ comparative study of the effectiveness of mezlocillin and ampicillin on respiratory tract infection ( author 's transl ] . | NA | {
"id": "C0025893",
"name": "mezlocillin",
"pos": [
44,
55
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
60,
70
]
} |
additions of carnauba wax , like to the case of ternary mixtures , had an effect on the viscoelastic properties of quaternary mixtures , but the temperature dependence of g ' and tan delta of these waxes were slightly broader than that of ternary mixtures in the region of higher temperature . | NA | {
"id": "C0054803",
"name": "carnauba wax",
"pos": [
13,
25
]
} | {
"id": "C0043076",
"name": "waxes",
"pos": [
198,
203
]
} |
dietary exposure to as caused increased urinary excretion of uroporphyrin and to a lesser extent coproporphyrin , whereas dietary cd caused no significant changes in urinary levels of any of the porphyrins measured . | NA | {
"id": "C0009988",
"name": "coproporphyrin",
"pos": [
97,
111
]
} | {
"id": "C0032712",
"name": "porphyrins",
"pos": [
195,
205
]
} |
although all column methods removed a significant proportion of test material containing single-stranded dna , only mak columns consistently yielded homogeneous double-stranded dna preparations . | NA | {
"id": "C0012935",
"name": "single-stranded dna",
"pos": [
89,
108
]
} | {
"id": "C0012854",
"name": "double-stranded dna",
"pos": [
161,
180
]
} |
it is concluded that methods of column chromatography are variably effective in reducing the proportion of single-stranded dna in mixed dna preparations . | NA | {
"id": "C0012935",
"name": "single-stranded dna",
"pos": [
107,
126
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
136,
139
]
} |
the correlation between the crystal habit and the composition of cholesterol crystals formed in four organic solvents ( methanol , acetonitrile , ethanol , and acetone ) was studied . | NA | {
"id": "C0001963",
"name": "methanol",
"pos": [
120,
128
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
146,
153
]
} |
the in vivo absorption of alpha-tocopherol from micellar solubilized solutions of free alpha-tocopherol and alpha-tocopheryl acetate was investigated using isolated loops of rat jejunum and found to be similar . | NA | {
"id": "C0969677",
"name": "alpha-tocopherol",
"pos": [
26,
42
]
} | {
"id": "C1999896",
"name": "alpha-tocopheryl acetate",
"pos": [
108,
132
]
} |
vitamin a antibodies were obtained using retinoic acid conjugated to human serum albumin as an immunogen . | NA | {
"id": "C0042839",
"name": "vitamin a",
"pos": [
0,
9
]
} | {
"id": "C0040845",
"name": "retinoic acid",
"pos": [
41,
54
]
} |
two distinct properties of antigen-presenting peripheral blood mononuclear cells were studied : ( a ) the ability for appropriate cell surface constituents to construct an immunogenic moiety , and ( b ) the ability to present similar antigenic determinants when they are not covalently bound . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
27,
34
]
} | {
"id": "C0003316",
"name": "antigenic",
"pos": [
234,
243
]
} |
two distinct properties of antigen-presenting peripheral blood mononuclear cells were studied : ( a ) the ability for appropriate cell surface constituents to construct an immunogenic moiety , and ( b ) the ability to present similar antigenic determinants when they are not covalently bound . | NA | {
"id": "C1321301",
"name": "peripheral blood mononuclear cells",
"pos": [
46,
80
]
} | {
"id": "C0007634",
"name": "the",
"pos": [
262,
265
]
} |
prostaglandin ( pg ) assays of plasma from the carotid artery and jugular vein during fever episodes revealed a surge of pge and pgf coincident with the pressor response and the first phase of fever , but pg were not detected in plasma samples taken throughout the second phase of fever . | NA | {
"id": "C0033559",
"name": "pge",
"pos": [
121,
124
]
} | {
"id": "C0033554",
"name": "pg",
"pos": [
205,
207
]
} |
previous work has shown that adults and older children tend to classify multi-dimensional objects by identity on one dimension , whereas children under 8 years of age tend to classify these same objects by a relation of overall similarity . | NA | {
"id": "C1455726",
"name": "older children",
"pos": [
40,
54
]
} | {
"id": "C0008059",
"name": "children",
"pos": [
137,
145
]
} |
electrophoretic variants for the stomach isozyme ( adh-c2 ) and liver isozyme ( adh-a2 ) of alcohol dehydrogenase in strains of mus musculus have been used in genetic analyses to demonstrate close linkage between the structural genes ( ahd-3 and adh-1 , respectively ) encoding these enzymes . | NA | {
"id": "C0022173",
"name": "isozyme",
"pos": [
41,
48
]
} | {
"id": "C0014442",
"name": "enzymes",
"pos": [
284,
291
]
} |
the ionic properties of this interferon were characterized by chromatography on cation and anion exchangers and also by isoelectric focusing when two components were observed : a major component , pi 5.8 and a minor component , pi 6.6 . | NA | {
"id": "C0022023",
"name": "ionic",
"pos": [
4,
9
]
} | {
"id": "C0007447",
"name": "cation",
"pos": [
80,
86
]
} |
the ionic properties of this interferon were characterized by chromatography on cation and anion exchangers and also by isoelectric focusing when two components were observed : a major component , pi 5.8 and a minor component , pi 6.6 . | NA | {
"id": "C0022023",
"name": "ionic",
"pos": [
4,
9
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
91,
96
]
} |
preparations of antibodies were shown to be strictly type-specific in the neutralization test but formed immune complexes adsorbable on staphylococcus aureus , cowan i strain cells , with heterotypic as well as homotypic virus-specific polypeptides present in extracts from the virus-infected cells . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
16,
26
]
} | {
"id": "C0003313",
"name": "immune complexes",
"pos": [
105,
121
]
} |
the proteins were reconstituted into single bilayer lipid vesicles by : ( i ) exchanging the non-dialysable detergent nonidet p40 ( np40 ) for a dialysable one , octylglucoside , while the proteins were immobilized on the lectin column and ( ii ) co-dialysis of the eluted glycoproteins in octylglucoside with phosphatid... | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
4,
12
]
} | {
"id": "C0023206",
"name": "lectin",
"pos": [
222,
228
]
} |
antigenic drift occurred in each of the 12 different epitopes studied and there was evidence that at least two antigenically distinguishable influenza b virus strains can co-circulate during an epidemic . | NA | {
"id": "C0003320",
"name": "antigenic",
"pos": [
0,
9
]
} | {
"id": "C0003316",
"name": "epitopes",
"pos": [
53,
61
]
} |
radioimmunoprecipitation and polyacrylamide gel electrophoresis showed that in five of the hybrid lines the antibodies were directed against haemagglutinin , in two against the nucleoprotein , and in one against l protein . | NA | {
"id": "C0028612",
"name": "nucleoprotein",
"pos": [
177,
190
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
214,
221
]
} |
simian virus 40 ( sv40 ) -infected and -transformed cell contain , in addition to the virus-coded tumour antigens , one or more 48k to 56k host tumour antigens . | NA | {
"id": "C0003320",
"name": "antigens",
"pos": [
105,
113
]
} | {
"id": "C0003335",
"name": "tumour antigens",
"pos": [
144,
159
]
} |
at 39 degrees c , hvj cl.14 was rescued by coinfected hvje at about 900- to 13 000-fold over single infection . | NA | {
"id": "C0275524",
"name": "coinfected",
"pos": [
43,
53
]
} | {
"id": "C0009450",
"name": "infection",
"pos": [
100,
109
]
} |
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