text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
examination of viral rna metabolism in mouse neuroblastoma ( n-18 ) cells revealed that rna synthesis of the cns isolates was decreased considerably at elevated temperatures ( up to 80 or 90 % at 39 degrees c ) . | NA | {
"id": "C0035736",
"name": "viral",
"pos": [
15,
20
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
88,
91
]
} |
of 165 tested sera , 153 ( 90.3 % ) had detectable levels of neutralizing antibodies , and the rest had no antibodies after this time . | NA | {
"id": "C0475463",
"name": "neutralizing",
"pos": [
61,
73
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
107,
117
]
} |
lastly the scg are active points of concurrency for hormone signals , as revealed by the metabolic changes induced by steroid and anterior pituitary hormones in these structures even in the absence of intact preganglionic connections , as well as by the existence of putative receptors for some of the hormones , namely ... | NA | {
"id": "C0019932",
"name": "hormones",
"pos": [
149,
157
]
} | {
"id": "C0001617",
"name": "corticosteroids",
"pos": [
351,
366
]
} |
from the stem bark of strychnos decussata ( pappe ) gilg ( loganiaceae ) , four tertiary indole alkaloids have been isolated : bisnordihydrotoxiferine and three new alkaloids . | NA | {
"id": "C0949738",
"name": "indole alkaloids",
"pos": [
89,
105
]
} | {
"id": "C0002062",
"name": "alkaloids",
"pos": [
165,
174
]
} |
the compounds were all derivatives of either tryptamine or n , n-dimethyltryptamine possessing hydroxy or methoxy substituents on the benzene ring portion of the indole nucleus . | NA | {
"id": "C0041248",
"name": "tryptamine",
"pos": [
45,
55
]
} | {
"id": "C0027183",
"name": "dimethyltryptamine",
"pos": [
65,
83
]
} |
experiments using antiserum to nerve growth factor ( ngf ) and purified antibody to cold-insoluble globulin ( cig ) indicated that the tropic effect of pcm was not derived from ngf or cig . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
18,
27
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
72,
80
]
} |
twenty normal volunteers had measurements of 24-hr whole-body retention ( wbr ) of three structurally related tc-99m-labeled phosphonate skeletal imaging agents : ( 1-hydroxyethylidene ) diphosphonate ( hedp ) , methylene diphosphonate ( mdp ) , and hydroxymethylene diphosphonate ( hmdp ) . | NA | {
"id": "C0012544",
"name": "diphosphonate",
"pos": [
187,
200
]
} | {
"id": "C0066351",
"name": "methylene diphosphonate",
"pos": [
257,
280
]
} |
we have postulated that the osteopenia produced by feeding excess free saa may be due to decreased bone formation caused by a reaction between homocysteine and the aldehyde groups of collagen , as in genetic homo-cystinuric osteoporosis . | NA | {
"id": "C0002527",
"name": "saa",
"pos": [
71,
74
]
} | {
"id": "C0019878",
"name": "homocysteine",
"pos": [
143,
155
]
} |
thr/teaa ratio was significantly higher ( p less than 0.05 ) at 3 hours but not so at 4 hours . | NA | {
"id": "C0040005",
"name": "thr",
"pos": [
0,
3
]
} | {
"id": "C0002525",
"name": "teaa",
"pos": [
4,
8
]
} |
the livers of rats ( 190-210 g ) fed casein ( a phosphoprotein ) or lactalbumin ( non-phosphoprotein ) diets ( 200 g protein/kg diet ) were perfused for 20 , 40 , or 60 minutes with 5 microci of [ 14c ] leucine . | NA | {
"id": "C0031689",
"name": "phosphoprotein",
"pos": [
48,
62
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
117,
124
]
} |
adenine , the precursor of nucleic acids in intestinal cells unable to synthesize purines de novo . | NA | {
"id": "C0001407",
"name": "adenine",
"pos": [
0,
7
]
} | {
"id": "C0034140",
"name": "purines",
"pos": [
82,
89
]
} |
de novo purine synthesis and purine reutilization were measured as the rate of incorporation of [ 14c ] -glycine or [ 14c ] -adenine , respectively , into the adenine and guanine pools of the intestinal cells . | NA | {
"id": "C0034140",
"name": "purine",
"pos": [
8,
14
]
} | {
"id": "C0001407",
"name": "adenine",
"pos": [
159,
166
]
} |
a method for simultaneous determination of 25-hydroxyvitamin d2 ( 25-oh-d2 ) and 25-hydroxyvitamin d3 ( 25-oh-d3 ) in human plasma has been developed by using two steps of high-performance liquid chromatography ( hplc ) . | NA | {
"id": "C0006657",
"name": "25-hydroxyvitamin d3",
"pos": [
81,
101
]
} | {
"id": "C2713074",
"name": "25-oh-d3",
"pos": [
104,
112
]
} |
a high-performance liquid chromatographic method for simultaneous assay of 25-hydroxyvitamin d2 ( 25-oh-d2 ) and 25-hydroxyvitamin d3 ( 25-oh-d3 ) proposed in a previous paper ( 1 ) was applied to determine the plasma levels of the metabolites in perinatal and postnatal periods . | NA | {
"id": "C0006657",
"name": "25-hydroxyvitamin d3",
"pos": [
113,
133
]
} | {
"id": "C2713074",
"name": "25-oh-d3",
"pos": [
136,
144
]
} |
escherichia coli kg980 , a vitamin b6 auxotroph derived from wild strain k12 , concentrated exogenous pyridoxal in an energy-dependent manner , and the effects of energy sources and inhibitors on pyridoxal uptake , compared with those on proline uptake indicated that the energy required was in the form of phosphate bon... | NA | {
"id": "C0087162",
"name": "vitamin b6",
"pos": [
27,
37
]
} | {
"id": "C0034263",
"name": "pyridoxal",
"pos": [
196,
205
]
} |
the liver cholesterol decreased in both groups of rabbits to a similar extent . beta-sitostanol prevented more effectively the formation of dietary cholesterol-induced atheroma in the abdominal aorta than beta-sitosterol . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
10,
21
]
} | {
"id": "C0008395",
"name": "dietary cholesterol",
"pos": [
140,
159
]
} |
metabolic inhibitors ( dinitrophenol , dnp and monoiodoacetic acid , iaa ) produced qualitatively the same changes in the electrical and mechanical activities . | NA | {
"id": "C0012466",
"name": "dinitrophenol",
"pos": [
23,
36
]
} | {
"id": "C0045511",
"name": "dnp",
"pos": [
39,
42
]
} |
on the other hand , the excretion of calcium into the bile of thyroparathyroidectomized rats intraperitoneally injected with the calcium chloride ( 4.0 mg ca/100 g ) was markedly increased by the administration of ct ( 20 or 80 mrc mu/100 g ) or histamine ( 0.1 mg/100 g ) . | NA | {
"id": "C0006675",
"name": "calcium",
"pos": [
37,
44
]
} | {
"id": "C0006686",
"name": "calcium",
"pos": [
129,
136
]
} |
the influences of bradykinin , kallidin and dipeptidyl carboxypeptidase ( kininase ii ) on the motility of human sperm thoroughly washed with ficoll were investigated by an objective method with multiple exposure photography technique which recorded stroboscopically the tract of sperm migration . | NA | {
"id": "C0006100",
"name": "bradykinin",
"pos": [
18,
28
]
} | {
"id": "C0022474",
"name": "kallidin",
"pos": [
31,
39
]
} |
addition of 0.1 -- 10 ng/ml of bradykinin or kallidin to sperm suspension caused a stimulation of motility . | NA | {
"id": "C0006100",
"name": "bradykinin",
"pos": [
31,
41
]
} | {
"id": "C0022474",
"name": "kallidin",
"pos": [
45,
53
]
} |
in two dogs , 5-ht ( 30 micrograms kg-1 i.v . ) markedly increased the venous plasma concentrations of noradrenaline and adrenaline . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
103,
116
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
121,
131
]
} |
fluorescence spectroscopic analysis of the hydrogen bonding properties of catecholamines , resorcinolamines , and related compounds with phosphate and other anionic species in aqueous solution . | NA | {
"id": "C0031603",
"name": "phosphate",
"pos": [
137,
146
]
} | {
"id": "C0003075",
"name": "anionic",
"pos": [
157,
164
]
} |
fluorescence spectroscopic analysis based upon the difference in fluorescent behaviour of several phenol , catechol and resorcinol derivatives in 0.2 m phosphate and water , at different ph values ranging from 7.4 to 1.0 , produced evidence for the existence of complexes between phosphate anions and these compounds . | NA | {
"id": "C0031428",
"name": "phenol",
"pos": [
98,
104
]
} | {
"id": "C0035197",
"name": "resorcinol",
"pos": [
120,
130
]
} |
fluorescence spectroscopic analysis based upon the difference in fluorescent behaviour of several phenol , catechol and resorcinol derivatives in 0.2 m phosphate and water , at different ph values ranging from 7.4 to 1.0 , produced evidence for the existence of complexes between phosphate anions and these compounds . | NA | {
"id": "C0031603",
"name": "phosphate",
"pos": [
152,
161
]
} | {
"id": "C0003075",
"name": "anions",
"pos": [
290,
296
]
} |
a comparison of different ligand structures revealed that the complex formation observed with unsubstituted phenol , catechol or resorcinol was not influenced by ethyl substitution ; | NA | {
"id": "C0031428",
"name": "phenol",
"pos": [
108,
114
]
} | {
"id": "C0035197",
"name": "resorcinol",
"pos": [
129,
139
]
} |
this pattern of disposition and excretion is similar to that reported elsewhere for the bibenzyl , hexoestrol , and for the stilbene , diethylstilboestrol . | NA | {
"id": "C0019467",
"name": "hexoestrol",
"pos": [
99,
109
]
} | {
"id": "C0012203",
"name": "diethylstilboestrol",
"pos": [
135,
154
]
} |
this pattern of disposition and excretion is similar to that reported elsewhere for the bibenzyl , hexoestrol , and for the stilbene , diethylstilboestrol . | NA | {
"id": "C0038333",
"name": "stilbene",
"pos": [
124,
132
]
} | {
"id": "C0012203",
"name": "diethylstilboestrol",
"pos": [
135,
154
]
} |
[ studies on the metabolic fate of tulobuterol . v. species differences in the metabolism and excretion in rat , dog , guinea pig and rabbit ( author 's transl ) ] . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
79,
89
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
94,
103
]
} |
the elaboration of a more complete multicompartmental model for ethanol should prove beneficial in revealing the relationships among the doses of alcohol , the circulating blood ethanol concentrations , and physiological and psychomotor test parameters . | NA | {
"id": "C0001962",
"name": "alcohol",
"pos": [
146,
153
]
} | {
"id": "C0684262",
"name": "blood ethanol concentrations",
"pos": [
172,
200
]
} |
arterial and venous blood alcohol concentration ( bac ) -time courses were completely defined in the peripheral circulations , both during and after the constant rate infusions of ethanol via the cephalic vein or hepatic artery in the dog . | NA | {
"id": "C0684262",
"name": "blood alcohol concentration",
"pos": [
20,
47
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
180,
187
]
} |
( 6 ) bac was observed to be higher for the same sampling times at the respective sites when ethanol was administered directly into the liver . | NA | {
"id": "C0684262",
"name": "bac",
"pos": [
6,
9
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
93,
100
]
} |
the elaboration of the arterial-venous concentration differences for ethanol should prove beneficial in revealing the relationships among the doses of alcohol , the circulating blood ethanol concentrations , and physiological and psychomotor test parameters in man . | NA | {
"id": "C0001962",
"name": "alcohol",
"pos": [
151,
158
]
} | {
"id": "C0684262",
"name": "blood",
"pos": [
177,
182
]
} |
we have examined four mathematical systems modeling the transit of the steroid anesthetic alphaxalone ( 3 alpha-hydroxy-5 alpha-pregnane-11,20-dione ) through the lung . | NA | {
"id": "C0038317",
"name": "steroid",
"pos": [
71,
78
]
} | {
"id": "C0033006",
"name": "pregnane",
"pos": [
128,
136
]
} |
the binding reaction was dependent on oxygen , nadph , reaction time , microsomal protein content and substrate concentration and was inhibited by carbon monoxide , glutathione and albumin . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
82,
89
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
181,
188
]
} |
moreover , it has been postulated that the glucose moiety of gtg binds to glucoreceptors in the vmh to focus the cytoxicity of the gold thioportion at that site . | NA | {
"id": "C0018033",
"name": "gtg",
"pos": [
61,
64
]
} | {
"id": "C0018026",
"name": "gold",
"pos": [
131,
135
]
} |
the metabolism and excretion of styrene oxide-glutathione conjugates in the rat and by isolated perfused liver , lung and kidney preparations . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
4,
14
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
19,
28
]
} |
the metabolism and excretion of styrene oxide-glutathione conjugates were studied in the intact rat and by isolated perfusion techniques in rat lung , liver and kidney . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
4,
14
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
19,
28
]
} |
the intact animals converted the styrene oxide-glutathione conjugates almost entirely to styrene oxide-n-acetylcysteine derivatives mercapturic acids ) , with much smaller amounts of cysteine , cysteinylglycine and ( unchanged ) glutathione conjugates . | NA | {
"id": "C0001047",
"name": "mercapturic acids",
"pos": [
132,
149
]
} | {
"id": "C0010654",
"name": "cysteine",
"pos": [
183,
191
]
} |
a high-performance liquid chromatographic method for analysis of acetaminophen and its conjugated metabolites in tissues was developed and used to determine tissue , plasma and urine levels of the drug and its glucuronic acid , sulfate , glutathione , cysteine mercapturic acid conjugates in mice given a 500 mg/kg oral ... | NA | {
"id": "C0010654",
"name": "cysteine",
"pos": [
252,
260
]
} | {
"id": "C0001047",
"name": "mercapturic acid",
"pos": [
261,
277
]
} |
exogenous 3 mm cyclic amp and 3 mm dibutyryl cyclic amp did not alter pge2 synthesis . | NA | {
"id": "C0001455",
"name": "cyclic amp",
"pos": [
15,
25
]
} | {
"id": "C0012054",
"name": "dibutyryl cyclic amp",
"pos": [
35,
55
]
} |
the effects of dibutyryl camp were specific , because butyrate and 5'-amp , possible metabolites of the camp analog , reversed the blockade by morphine and met-enkephalin of the nociceptive stimulus-evoked neuronal firing much less frequently ( 29 % ) . | NA | {
"id": "C0012054",
"name": "dibutyryl camp",
"pos": [
15,
29
]
} | {
"id": "C0001455",
"name": "camp",
"pos": [
104,
108
]
} |
the effects of ryanodine , a neutral alkaloid , on crab muscle fibers were investigated under voltage clamp conditions using the double sucrose-gap technique . | NA | {
"id": "C0035983",
"name": "ryanodine",
"pos": [
15,
24
]
} | {
"id": "C0002062",
"name": "alkaloid",
"pos": [
37,
45
]
} |
different types of serotonin receptors in basal ganglia suggest that altered serotonin neurotransmission might be involved in the catalepsy or dyskinesias produced by neuroleptic therapy . | NA | {
"id": "C0007370",
"name": "catalepsy",
"pos": [
130,
139
]
} | {
"id": "C0013384",
"name": "dyskinesias",
"pos": [
143,
154
]
} |
and/or ( 2 ) occupation by 5-ht of either noradrenergic or dopaminergic receptors , or both classes of catecholamine receptors which are believed to mediate the hypothalamic pathways for heat loss . | NA | {
"id": "C0034798",
"name": "dopaminergic receptors",
"pos": [
59,
81
]
} | {
"id": "C0054861",
"name": "catecholamine",
"pos": [
103,
116
]
} |
the distribution of na pump sites ( na+-k+ atpase ) in the acinar cells of dog submandibular gland was demonstrated by light and electron microscopical radioautography of 3h-ouabain binding sites and electron microscopical atpase cytochemistry . | NA | {
"id": "C0001479",
"name": "na",
"pos": [
20,
22
]
} | {
"id": "C0001473",
"name": "atpase",
"pos": [
223,
229
]
} |
the present evidence that the distribution of atpase on the acinar cells determined by the cytochemistry is well concomitant with that of 3h-ouabain binding sites on the acinar cells by the radioautography , suggests that the above mentioned atpase is na+-k+ atpase , a na pump . | NA | {
"id": "C0001473",
"name": "atpase",
"pos": [
46,
52
]
} | {
"id": "C0001479",
"name": "na",
"pos": [
270,
272
]
} |
five men ( 2.7 % ) , 3 with ankylosing spondylitis and 2 with reiter 's disease , had coexistent classical ra and 2 of these also had felty 's syndrome . | NA | {
"id": "C0003873",
"name": "ra",
"pos": [
107,
109
]
} | {
"id": "C0015773",
"name": "felty 's syndrome",
"pos": [
134,
151
]
} |
linear regression of salivary glucose on blood glucose gave a simple correlation coefficient of 0.18 ( ns ) . | NA | {
"id": "C0017725",
"name": "glucose",
"pos": [
30,
37
]
} | {
"id": "C0005802",
"name": "blood",
"pos": [
41,
46
]
} |
a series of nucleoside analogues has been prepared , wherein the cyclic carbohydrate moiety is replaced by aliphatic side chains attached to cytosine , thymine , uracil , and 5-fluorouracil . | NA | {
"id": "C0040087",
"name": "thymine",
"pos": [
152,
159
]
} | {
"id": "C0041917",
"name": "uracil",
"pos": [
183,
189
]
} |
a series of nucleoside analogues has been prepared , wherein the cyclic carbohydrate moiety is replaced by aliphatic side chains attached to cytosine , thymine , uracil , and 5-fluorouracil . | NA | {
"id": "C0041917",
"name": "uracil",
"pos": [
162,
168
]
} | {
"id": "C0016360",
"name": "5-fluorouracil",
"pos": [
175,
189
]
} |
the carbocyclic analogues of 5-fluoro-2'-deoxyuridine ( 5-fdurd , 1 ) , 5-fluorouridine , and 5-fluoro-3 alpha-deoxyuridine were prepared by fluorination of the uracil nucleoside analogues with elemental fluorine . | NA | {
"id": "C0016343",
"name": "fdurd",
"pos": [
58,
63
]
} | {
"id": "C0011535",
"name": "deoxyuridine",
"pos": [
111,
123
]
} |
the 5-fdurd analogue ( c-5-f-2'-durd , 6 ) was enzymatically phosphorylated to the analogue of 5-fdurd 5'-phosphate and inhibited the incorporation of 2'-deoxyuridine into dna of murine colon 26 tumor cells and l-1210 cells in culture . | NA | {
"id": "C0016343",
"name": "fdurd",
"pos": [
6,
11
]
} | {
"id": "C0011535",
"name": "deoxyuridine",
"pos": [
154,
166
]
} |
the quaternary benzophenanthridine alkaloids sanguinarine ( 1 ) and chelerythrine ( 2 ) inhibit rat liver l-alanine-:2-oxoglutarate aminotransferase ( ec 2.6.1.2 ) activity . | NA | {
"id": "C1720921",
"name": "benzophenanthridine",
"pos": [
15,
34
]
} | {
"id": "C0002062",
"name": "alkaloids",
"pos": [
35,
44
]
} |
blood mononuclear cells with suppressor activity in patients with thyroid disorders : increased levels of t gamma cells in subacute thyroiditis . | NA | {
"id": "C1321301",
"name": "blood mononuclear cells",
"pos": [
0,
23
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
114,
119
]
} |
complement levels were elevated in a large percentage of patients , reaching statistical significance for c3 , c4 , c5 , factor b and properdin . | NA | {
"id": "C0009498",
"name": "complement",
"pos": [
0,
10
]
} | {
"id": "C0033453",
"name": "factor b",
"pos": [
121,
129
]
} |
in 6 or 7 short term cancer cell lines studied , the addition of 10 ( 3 ) cells to mitogen- or alloantigen-stimulated cultures of 10 ( 5 ) pbmc caused from 20 to 60 % suppression of 3h thymidine incorporation . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
74,
79
]
} | {
"id": "C1321301",
"name": "pbmc",
"pos": [
139,
143
]
} |
one of the tumor cells caused suppression when separated from the pbmc by a cell-impermeable membrane while another line required cell-to-cell contact for suppression . | NA | {
"id": "C1321301",
"name": "pbmc",
"pos": [
66,
70
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
138,
142
]
} |
further analyses using separated recombinant dna strands and restriction fragments indicated that all mrna 's were encoded by the leftward-reading dna strand and at least two were overlapping . | NA | {
"id": "C0012931",
"name": "recombinant dna",
"pos": [
33,
48
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
147,
150
]
} |
previous studies of herpesvirus infections have indicated that a virus-specified thymidine kinase is required for the initial phosphorylation of acyclovir [ acycloguanosine or 9- ( 2-hydroxyethoxymethyl ) guanine ] in the formation of acycloguanosine triphosphate . | NA | {
"id": "C0001367",
"name": "acycloguanosine",
"pos": [
157,
172
]
} | {
"id": "C0018321",
"name": "guanine",
"pos": [
205,
212
]
} |
the dnas of the lambda recombinants were used to transfect nih3t3 mouse fibroblasts in order to obtain harvey murine sarcoma virus dna-induced foci of transformed cells . | NA | {
"id": "C0012931",
"name": "dnas",
"pos": [
4,
8
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
131,
134
]
} |
no major differences in complexity were observed between circular dna and linear virion dna from b95-8 cells . | NA | {
"id": "C0012925",
"name": "circular dna",
"pos": [
57,
69
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
88,
91
]
} |
we constructed a physical map of kilham rat virus strains 171 dna by analyzing the sizes and locations of restriction endonuclease-generated fragments of the replicative-form viral dna synthesized in vitro . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
62,
65
]
} | {
"id": "C0012939",
"name": "viral dna",
"pos": [
175,
184
]
} |
by screening a library of unintegrated , circular moloney murine leukemia virus ( m-mulv ) dna cloned in lambda phage , we found that approximately 20 % of the m-mulv dna inserts contained internal sequence deletions or inversions . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
13,
14
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
167,
170
]
} |
the autointegrated m-mulv dna had generally lost two base pairs from the ltr sequence at each junction with target site dna , whereas a four-base-pair direct repeat of target site dna flanked the integrated viral dna . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
26,
29
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
215,
216
]
} |
the autointegrated m-mulv dna had generally lost two base pairs from the ltr sequence at each junction with target site dna , whereas a four-base-pair direct repeat of target site dna flanked the integrated viral dna . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
26,
29
]
} | {
"id": "C0012939",
"name": "viral dna",
"pos": [
207,
216
]
} |
rnase t1 oligonucleotide mapping of purified viral rnas indicated that ur1 rna contains eight unique oligonucleotides in the middle of the genome and shares four 5'-terminal and three 3'-terminal oligonucleotides with ur1av rna . | NA | {
"id": "C0035736",
"name": "viral rnas",
"pos": [
45,
55
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
224,
227
]
} |
our results indicate that the accumulation of b-tropic proviral dna in nih cells may be inhibited at either the level of linear ( form iii ) or covalently closed circular dna ( form i ) , depending upon the degree of restriction of the clone of virus used . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
64,
67
]
} | {
"id": "C0012925",
"name": "circular dna",
"pos": [
162,
174
]
} |
laboratory and clinical studies were performed on a newly introduced antibiotic of the cephamycin series , cefoxitin ( cfx ) , and the results obtained were as follows : 1 . | NA | {
"id": "C0007736",
"name": "cephamycin",
"pos": [
87,
97
]
} | {
"id": "C0007557",
"name": "cefoxitin",
"pos": [
107,
116
]
} |
clinical trials of cefoxitin , a new cephamycin antibiotic were carried out on 17 infantile patients with infections ( respiratory tract infection 15 , meningitis 1 and sepsis 1 ) . | NA | {
"id": "C0007557",
"name": "cefoxitin",
"pos": [
19,
28
]
} | {
"id": "C0007736",
"name": "cephamycin",
"pos": [
37,
47
]
} |
fundamental and clinical evaluations were made on cefoxitin , a new cephamycin antibiotic , and the following results were obtained . | NA | {
"id": "C0007557",
"name": "cefoxitin",
"pos": [
50,
59
]
} | {
"id": "C0007736",
"name": "cephamycin",
"pos": [
68,
78
]
} |
using a new cephamycin antibiotic , cefoxitin , clinical studies were carried out , and the following results were obtained : ( 1 ) cefoxitin was administered to 52 children with 38 respiratory tract infections , 2 urinary tract infections , 1 acute otitis media and others , who ranged in age from 2 months to 11 years ... | NA | {
"id": "C0007736",
"name": "cephamycin",
"pos": [
12,
22
]
} | {
"id": "C0007557",
"name": "cefoxitin",
"pos": [
132,
141
]
} |
in order to ascertain the therapeutic effects of cefoxitin ( cfx ) , a new semisynthetic cephamycin antibiotic , it was administered to pediatric patients with several infections . | NA | {
"id": "C0007557",
"name": "cefoxitin",
"pos": [
49,
58
]
} | {
"id": "C0007736",
"name": "cephamycin",
"pos": [
89,
99
]
} |
pharmacokinetics of cefoxitin , a new injectable semisynthetic-cephamycin , was studied in 12 healthy children and also was studied cerebrospinal fluid levels in 1 patient with bacterial meningitis received 44.5 mg/kg of cefoxitin and thoracic fluid levels in 2 patients were measured . | NA | {
"id": "C0007736",
"name": "cephamycin",
"pos": [
63,
73
]
} | {
"id": "C0007557",
"name": "cefoxitin",
"pos": [
221,
230
]
} |
with cephalosporins , the blood and urine levels of cephalothin ( cet ) , cefoxitin ( cfx ) , cephalexin ( cex ) ( 2,3 ) , cefazolin ( cez ) ( 4 ) , cefuroxime ( cxm ) ( 5 ) , cephaloridine ( cer ) ( 6 ) and cefradine ( ced ) ( 7 ) determined by high-performance liquid chromatography ( hplc ) have been reported . | NA | {
"id": "C3536856",
"name": "cephalosporins",
"pos": [
5,
19
]
} | {
"id": "C0007727",
"name": "cephaloridine",
"pos": [
176,
189
]
} |
with cephalosporins , the blood and urine levels of cephalothin ( cet ) , cefoxitin ( cfx ) , cephalexin ( cex ) ( 2,3 ) , cefazolin ( cez ) ( 4 ) , cefuroxime ( cxm ) ( 5 ) , cephaloridine ( cer ) ( 6 ) and cefradine ( ced ) ( 7 ) determined by high-performance liquid chromatography ( hplc ) have been reported . | NA | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
94,
104
]
} | {
"id": "C0007738",
"name": "cefradine",
"pos": [
208,
217
]
} |
ctx was almost equally active to sce-1365 and less active than cefotiam ( ctm ) and cefazolin ( cez ) against s. aureus , much more active than these 3 antibiotics against e. coli , more active than the 3 antibiotics against enterobacter , equally active to sce-1365 and a little weaker than cez against anaerobic gram p... | NA | {
"id": "C0007554",
"name": "ctx",
"pos": [
0,
3
]
} | {
"id": "C0007556",
"name": "cefotiam",
"pos": [
63,
71
]
} |
the changes , considered to be drug-related , were histopathological changes at the sites of injection , which consisted inflammatory cellular infiltration , hemorrhage and hyperplasia of fibroblast in connective tissue of skin and skeletal muscle . | NA | {
"id": "C0007634",
"name": "cellular",
"pos": [
134,
142
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
188,
198
]
} |
8 cases of urinary tract infection , 15 cases of respiratory tract infection , 1 case of staphylococcal scalded skin syndrome , 1 case of peritonitis , 2 cases of purulent meningitis , with the dose of 6059-s 150 mg/kg/day in purulent meningitis , 40-80 mg/kg/day in other disease . | NA | {
"id": "C0039082",
"name": "syndrome",
"pos": [
117,
125
]
} | {
"id": "C0012634",
"name": "disease",
"pos": [
273,
280
]
} |
the revealed phenomena are explained by the features of the 99mtc-pyrophosphate concentration mechanisms of the damaged areas of the myocardium . during the necrosis phase pyrophosphate is accumulated in the irreversibly damaged myocardial cells . | NA | {
"id": "C0085250",
"name": "99mtc-pyrophosphate",
"pos": [
60,
79
]
} | {
"id": "C0034320",
"name": "pyrophosphate",
"pos": [
172,
185
]
} |
although usr did not correlate directly with either dietary protein or energy , the percent of protein-derived calories allowed the prediction of usr from ni . | NA | {
"id": "C0012177",
"name": "dietary protein",
"pos": [
52,
67
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
95,
102
]
} |
an octapeptide analogue ( saralasin 10 ( -6 ) to 10 ( -2 ) g/liter ) was equally effective at blocking glomerular responses to both aii and aiii , but two heptapeptide analogues ( des-asp , 8-ile aii and des-asp , 8-gly aii ; 10 ( -6 ) to 10 ( -2 ) g/liter ) failed to block responses to either agonist . | NA | {
"id": "C0036193",
"name": "saralasin",
"pos": [
26,
35
]
} | {
"id": "C0003009",
"name": "aii",
"pos": [
220,
223
]
} |
but potassium clearance increased greatly when delivery of sodium to the distal nephron was increased by infusion of nonchloride anions : sulfate ( sodium sulfate infusion , low sodium chloride diet ; ck/gfr = 63.7 +/- 0.4 % ) or bicarbonate ( sodium bicarbonate plus acetazolamide infusion ; ck/gfr = 81.7 +/- 1.7 % ) . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
129,
135
]
} | {
"id": "C0038720",
"name": "sulfate",
"pos": [
155,
162
]
} |
but potassium clearance increased greatly when delivery of sodium to the distal nephron was increased by infusion of nonchloride anions : sulfate ( sodium sulfate infusion , low sodium chloride diet ; ck/gfr = 63.7 +/- 0.4 % ) or bicarbonate ( sodium bicarbonate plus acetazolamide infusion ; ck/gfr = 81.7 +/- 1.7 % ) . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
129,
135
]
} | {
"id": "C0008203",
"name": "chloride",
"pos": [
185,
193
]
} |
but potassium clearance increased greatly when delivery of sodium to the distal nephron was increased by infusion of nonchloride anions : sulfate ( sodium sulfate infusion , low sodium chloride diet ; ck/gfr = 63.7 +/- 0.4 % ) or bicarbonate ( sodium bicarbonate plus acetazolamide infusion ; ck/gfr = 81.7 +/- 1.7 % ) . | NA | {
"id": "C0038720",
"name": "sulfate",
"pos": [
138,
145
]
} | {
"id": "C0074769",
"name": "sodium sulfate",
"pos": [
148,
162
]
} |
but potassium clearance increased greatly when delivery of sodium to the distal nephron was increased by infusion of nonchloride anions : sulfate ( sodium sulfate infusion , low sodium chloride diet ; ck/gfr = 63.7 +/- 0.4 % ) or bicarbonate ( sodium bicarbonate plus acetazolamide infusion ; ck/gfr = 81.7 +/- 1.7 % ) . | NA | {
"id": "C0005367",
"name": "bicarbonate",
"pos": [
230,
241
]
} | {
"id": "C0074722",
"name": "sodium bicarbonate",
"pos": [
244,
262
]
} |
we suggest that the primary abnormality in this syndrome increases the reabsorptive avidity of the distal nephron for chloride , which ( 1 ) limits the sodium and mineralocorticoid-dependent voltage driving force for potassium and hydrogen ion secretion , resulting in hyperkalemia and acidosis and ( 2 ) augments distal... | NA | {
"id": "C0008203",
"name": "chloride",
"pos": [
118,
126
]
} | {
"id": "C0037494",
"name": "sodium",
"pos": [
321,
327
]
} |
among gn patients , the ones presenting membranous gn ( mgn ) , iga disease , and lipoid nephrosis associated with segmental and focal hyalinosis ( fgs ) showed significant decrease of their peripheral cytotoxic/suppressive t cells . | NA | {
"id": "C0017658",
"name": "gn",
"pos": [
6,
8
]
} | {
"id": "C0017668",
"name": "focal hyalinosis",
"pos": [
129,
145
]
} |
organic acids have been obtained in an alkaline medium from a mixture of monosaccharides-carbohydrates to be used in a closed life support system . | NA | {
"id": "C0026492",
"name": "monosaccharides",
"pos": [
73,
88
]
} | {
"id": "C0007004",
"name": "carbohydrates",
"pos": [
89,
102
]
} |
necrotic bronchitis and bronchiolitis with basophilic intranuclear inclusion bodies in bronchial epithelial cells were characteristic . | NA | {
"id": "C0006277",
"name": "bronchitis",
"pos": [
9,
19
]
} | {
"id": "C0006271",
"name": "bronchiolitis",
"pos": [
24,
37
]
} |
lesions associated with an infectious process such as renal abscesses , staphylococcal nephritis , pyelonephritis and pyelitis were the principal finding in rabbits up to 5 months of age , while renal fibrosis , with or without dystrophic calcification , was the most common lesion observed in rabbits aged over 10 month... | NA | {
"id": "C0027697",
"name": "nephritis",
"pos": [
87,
96
]
} | {
"id": "C0034183",
"name": "pyelitis",
"pos": [
118,
126
]
} |
the best results were recorded in toxic eczema and irritative dermatitis , contact dermatitis , psoriasis and atopic dermatitis . | NA | {
"id": "C0011603",
"name": "dermatitis",
"pos": [
62,
72
]
} | {
"id": "C0011615",
"name": "atopic",
"pos": [
110,
116
]
} |
the second carrier state is characterised by the presence of only integrated hbv dna sequences in the liver : viral dna and hbeag are not present in the serum . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
81,
84
]
} | {
"id": "C0012939",
"name": "viral dna",
"pos": [
110,
119
]
} |
the infant did not respond to high-dose intravenous penicillin g but was cured by a combination of ampicillin , chloramphenicol , and rifampicin . | NA | {
"id": "C0030827",
"name": "penicillin",
"pos": [
52,
62
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
99,
109
]
} |
at the infant 's day-care centre this multiply resistant strain was isolated from throat cultures of 27 % of the children ( age less than or equal to 26 months ) assigned to the same room as the index case , and from 11 % of older children and staff . | NA | {
"id": "C0008059",
"name": "children",
"pos": [
113,
121
]
} | {
"id": "C1455726",
"name": "older children",
"pos": [
225,
239
]
} |
it is the author 's opinion that allergic rhinitis , vasomotor rhinitis and nasal polyposis are nasal diseases with their own identity in the majority of instances . | NA | {
"id": "C0027430",
"name": "nasal polyposis",
"pos": [
76,
91
]
} | {
"id": "C0028432",
"name": "nasal diseases",
"pos": [
96,
110
]
} |
[ musculoskeletal syndrome in infective endocarditis and replacement of flail aortic valve in active disease ( author 's transl ) ] . | NA | {
"id": "C0039082",
"name": "syndrome",
"pos": [
18,
26
]
} | {
"id": "C0012634",
"name": "disease",
"pos": [
101,
108
]
} |
however , a close relationship was observed between the degree of 7 alpha-dehydroxylation of cholic acid ( expressed as the ratio of deoxycholic to the sum of deoxycholic and cholic acids ) and the percentage of cholesterol in the feces ( r = -0.921 , p less than 0.001 ) . | NA | {
"id": "C0055568",
"name": "cholic acid",
"pos": [
93,
104
]
} | {
"id": "C0008404",
"name": "cholic acids",
"pos": [
175,
187
]
} |
incorporation of [ 14c ] from acetoacetate , d ( - ) - and l ( + ) -3-hydroxybutyrate , glucose , glutamine , acetate and palmitate in cellular lipids were studied in cultures in human diploid fibroblasts ( hdf ) . | NA | {
"id": "C0007634",
"name": "cellular",
"pos": [
135,
143
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
193,
204
]
} |
the presence of low density lipoproteins ( ldl ) cholesterol ( 40 microgram cholesterol/ml ) inhibited the incorporation of [ 14c ] from acetoacetate 56 % into nonsaponifiable lipids ; | NA | {
"id": "C0023824",
"name": "low density lipoproteins",
"pos": [
16,
40
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
76,
87
]
} |
these data suggest that failure of tooth eruption in ia rats is directly related to the reduction in bone resorption and that alveolar bone resorption is required for tooth eruption . | NA | {
"id": "C0005974",
"name": "bone resorption",
"pos": [
101,
116
]
} | {
"id": "C0002382",
"name": "alveolar",
"pos": [
126,
134
]
} |
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