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conversely , pge2 inhibited the air to arginine in diabetics ( pge = 28 +/- 5 microunits/ml , control = 39 +/- 7 microunits/ml , n = 7 , p less than .05 ) , but not in normal subjects ( pge = 74 +/- 7 microunits/ml , control = 80 +/- 14 microunits/ml , n = 5 , p = ns ) .
NA
{ "id": "C0012472", "name": "pge2", "pos": [ 13, 17 ] }
{ "id": "C0033559", "name": "pge", "pos": [ 186, 189 ] }
to evaluate the essentiality of creatine and phosphocreatine for the maintenance of the ultrastructure of skeletal muscle , chicks were fed a creatine antagonist , beta-guanidinobutyric acid ( beta-gba ) , as 2 % of a chow diet .
NA
{ "id": "C0031634", "name": "phosphocreatine", "pos": [ 45, 60 ] }
{ "id": "C0010286", "name": "creatine", "pos": [ 142, 150 ] }
the pectoralis muscles of chicks given 6 % creatine in addition to 2 % beta-gba in the diet accumulated little beta-gba , maintained normal phosphocreatine concentrations , and exhibited no significant ultrastructural abnormalities .
NA
{ "id": "C0010286", "name": "creatine", "pos": [ 43, 51 ] }
{ "id": "C0031634", "name": "phosphocreatine", "pos": [ 140, 155 ] }
in those pups given enteric galactose , blood glucose values were equivalent to that in the glucose fed groups , however carbon-14 appearing in blood glucose and blood glucose specific activity was significantly lower .
NA
{ "id": "C0017725", "name": "glucose", "pos": [ 46, 53 ] }
{ "id": "C0005802", "name": "blood glucose", "pos": [ 162, 175 ] }
assays were performed in order to measure blood-clotting factors ( activity of the factor ii-vii-x complex , anti-thrombin iii , euglobulin lysis time ) and plasma lipids ( total cholesterol , triglycerides , lipoprotein electrophoresis ) before treatment and after 3 and 4 mth of treatment .
NA
{ "id": "C0005789", "name": "blood-clotting factors", "pos": [ 42, 64 ] }
{ "id": "C0040018", "name": "thrombin", "pos": [ 114, 122 ] }
excretory duct originating neoplasms consist of papillomas , epidermal and adenocarcinomas , while intercalated stem cell bound neoplasms embrace the canalicular adenoma , oncocytoma acinic cell and lobular carcinomata .
NA
{ "id": "C0001418", "name": "adenocarcinomas", "pos": [ 75, 90 ] }
{ "id": "C0206692", "name": "lobular carcinomata", "pos": [ 199, 218 ] }
in addition , some studies of naloxone and naltrexone suggest a relationship between a blockage in the action of endorphins and the development of a syndrome of dysphoric symptoms similar to the depressive features manifested premenstrually and postpartum by many women and frequently seen in some depressed outpatients ...
NA
{ "id": "C0027358", "name": "naloxone", "pos": [ 30, 38 ] }
{ "id": "C0027360", "name": "naltrexone", "pos": [ 43, 53 ] }
anterior pituitary peptides and some other human hormones were analyzed by a computerized step-by-step comparative method for the frequency and distribution of some specific amino acids with the property of having been coded by complementary nucleic acid triplets in the dna .
NA
{ "id": "C0028606", "name": "nucleic acid", "pos": [ 242, 254 ] }
{ "id": "C0012854", "name": "dna", "pos": [ 271, 274 ] }
glucose tester operating on ames blood glucose reagent strips achieved the highest recommendation over all .
NA
{ "id": "C0017725", "name": "glucose", "pos": [ 0, 7 ] }
{ "id": "C0005802", "name": "blood glucose", "pos": [ 33, 46 ] }
in the nerve specimen , polymorphous lysosomes were noted in perineural cells , in fibroblasts , and in endothelial and perithelial cells in association with some nonspecific degenerative changes .
NA
{ "id": "C0016030", "name": "fibroblasts", "pos": [ 83, 94 ] }
{ "id": "C0007634", "name": "cells", "pos": [ 132, 137 ] }
serum levels of seven specific proteins mostly acute phase reactants ( apr ) have been studied ( transferrin , alpha 2-macroglobulin , alpha 1-antitrypsin , haptoglobin , c3 , ceruloplasmin , orosomucoid ) in 14 healthy subjects and in 55 patients with multiple myeloma .
NA
{ "id": "C0001347", "name": "acute phase reactants", "pos": [ 47, 68 ] }
{ "id": "C0040679", "name": "transferrin", "pos": [ 97, 108 ] }
serum levels of seven specific proteins mostly acute phase reactants ( apr ) have been studied ( transferrin , alpha 2-macroglobulin , alpha 1-antitrypsin , haptoglobin , c3 , ceruloplasmin , orosomucoid ) in 14 healthy subjects and in 55 patients with multiple myeloma .
NA
{ "id": "C0001347", "name": "acute phase reactants", "pos": [ 47, 68 ] }
{ "id": "C0002191", "name": "alpha 1-antitrypsin", "pos": [ 135, 154 ] }
serum levels of seven specific proteins mostly acute phase reactants ( apr ) have been studied ( transferrin , alpha 2-macroglobulin , alpha 1-antitrypsin , haptoglobin , c3 , ceruloplasmin , orosomucoid ) in 14 healthy subjects and in 55 patients with multiple myeloma .
NA
{ "id": "C0001347", "name": "acute phase reactants", "pos": [ 47, 68 ] }
{ "id": "C0018595", "name": "haptoglobin", "pos": [ 157, 168 ] }
serum levels of seven specific proteins mostly acute phase reactants ( apr ) have been studied ( transferrin , alpha 2-macroglobulin , alpha 1-antitrypsin , haptoglobin , c3 , ceruloplasmin , orosomucoid ) in 14 healthy subjects and in 55 patients with multiple myeloma .
NA
{ "id": "C0001347", "name": "acute phase reactants", "pos": [ 47, 68 ] }
{ "id": "C0007841", "name": "ceruloplasmin", "pos": [ 176, 189 ] }
serum levels of seven specific proteins mostly acute phase reactants ( apr ) have been studied ( transferrin , alpha 2-macroglobulin , alpha 1-antitrypsin , haptoglobin , c3 , ceruloplasmin , orosomucoid ) in 14 healthy subjects and in 55 patients with multiple myeloma .
NA
{ "id": "C0001347", "name": "acute phase reactants", "pos": [ 47, 68 ] }
{ "id": "C0029297", "name": "orosomucoid", "pos": [ 192, 203 ] }
in the iga myeloma , however , decreased levels of haptoglobin and alpha 1-antitrypsin have been found in spite of being positive apr .
NA
{ "id": "C0002191", "name": "alpha 1-antitrypsin", "pos": [ 67, 86 ] }
{ "id": "C0001347", "name": "apr", "pos": [ 130, 133 ] }
concentrations of the following acute-phase reactants ( apr ) were determined in the sera of patients with benign and malignant ovarian tumors : haptoglobin , ceruloplasmin , sialic acid , seromucoid ( in sulphosalicylic acid supernatant ) , and trypsin inhibitory capacity .
NA
{ "id": "C0001347", "name": "acute-phase reactants", "pos": [ 32, 53 ] }
{ "id": "C0018595", "name": "haptoglobin", "pos": [ 145, 156 ] }
concentrations of the following acute-phase reactants ( apr ) were determined in the sera of patients with benign and malignant ovarian tumors : haptoglobin , ceruloplasmin , sialic acid , seromucoid ( in sulphosalicylic acid supernatant ) , and trypsin inhibitory capacity .
NA
{ "id": "C0001347", "name": "acute-phase reactants", "pos": [ 32, 53 ] }
{ "id": "C0007841", "name": "ceruloplasmin", "pos": [ 159, 172 ] }
concentrations of the following acute-phase reactants ( apr ) were determined in the sera of patients with benign and malignant ovarian tumors : haptoglobin , ceruloplasmin , sialic acid , seromucoid ( in sulphosalicylic acid supernatant ) , and trypsin inhibitory capacity .
NA
{ "id": "C0001347", "name": "acute-phase reactants", "pos": [ 32, 53 ] }
{ "id": "C0029297", "name": "seromucoid", "pos": [ 189, 199 ] }
taken with previous results from elevated divalent ion concentrations in sweat from crf patients , these findings suggest that the excretion of divalent electrolyte glands may represent a generalized abnormality in exocrine glands in crf .
NA
{ "id": "C0022023", "name": "ion", "pos": [ 51, 54 ] }
{ "id": "C0013832", "name": "electrolyte", "pos": [ 153, 164 ] }
pregnant sprague-dawley rats were daily administered either 20 mg/kg or naloxone hcl in saline or saline alone ip in two divided doses on days 7-20 of gestation ( i.e. , 40 mg/kg/day of naloxone ) .
NA
{ "id": "C0700549", "name": "naloxone", "pos": [ 72, 80 ] }
{ "id": "C0027358", "name": "naloxone", "pos": [ 186, 194 ] }
pregnant rats were intubated with beer , wine , whiskey , or ethanol ( 3 g/kg/day ) , twice daily , while control animals received an isocaloric solution .
NA
{ "id": "C0004922", "name": "beer", "pos": [ 34, 38 ] }
{ "id": "C0001962", "name": "ethanol", "pos": [ 61, 68 ] }
pregnant rats were intubated with beer , wine , whiskey , or ethanol ( 3 g/kg/day ) , twice daily , while control animals received an isocaloric solution .
NA
{ "id": "C0043188", "name": "wine", "pos": [ 41, 45 ] }
{ "id": "C0001962", "name": "ethanol", "pos": [ 61, 68 ] }
pregnant rats were intubated with beer , wine , whiskey , or ethanol ( 3 g/kg/day ) , twice daily , while control animals received an isocaloric solution .
NA
{ "id": "C0475610", "name": "whiskey", "pos": [ 48, 55 ] }
{ "id": "C0001962", "name": "ethanol", "pos": [ 61, 68 ] }
beer- and whiskey-treated animals were also less responsive than controls to ethanol challenge , but did not differ from ethanol-treated animals .
NA
{ "id": "C0004922", "name": "beer", "pos": [ 0, 4 ] }
{ "id": "C0001962", "name": "ethanol", "pos": [ 121, 128 ] }
beer- and whiskey-treated animals were also less responsive than controls to ethanol challenge , but did not differ from ethanol-treated animals .
NA
{ "id": "C0475610", "name": "whiskey", "pos": [ 10, 17 ] }
{ "id": "C0001962", "name": "ethanol", "pos": [ 121, 128 ] }
[ evolution from acute subdural hemorrhage to chronic subdural hematoma -- observation of subdural hematoma by computerized tomography ( author 's transl ) ] .
NA
{ "id": "C0749098", "name": "acute subdural hemorrhage", "pos": [ 17, 42 ] }
{ "id": "C0018946", "name": "subdural hematoma", "pos": [ 90, 107 ] }
[ evolution from acute subdural hemorrhage to chronic subdural hematoma -- observation of subdural hematoma by computerized tomography ( author 's transl ) ] .
NA
{ "id": "C0749095", "name": "chronic subdural hematoma", "pos": [ 46, 71 ] }
{ "id": "C0018946", "name": "subdural hematoma", "pos": [ 90, 107 ] }
plasma norepinephrine , epinephrine and dopamine responses to intracerebral administration of a met-enkephalin analog , d-ala2-met-enkephalinamide , in rats .
NA
{ "id": "C0028351", "name": "norepinephrine", "pos": [ 7, 21 ] }
{ "id": "C0014563", "name": "epinephrine", "pos": [ 24, 35 ] }
intracisternal ( i.c . ) administration ( 25 microgram or 42.6 nmol ) of the potent met-enkephalin analog , d-ala2-met-enkephalinamide ( dala ) in adult male rats increased plasma concentrations of norepinephrine and epinephrine for more than 90 min .
NA
{ "id": "C0028351", "name": "norepinephrine", "pos": [ 198, 212 ] }
{ "id": "C0014563", "name": "epinephrine", "pos": [ 217, 228 ] }
the data are consistent with an effect of dala acting at a presently unknown brain site to increase central sympathetic outflow , thus increasing plasma concentrations of norepinephrine and epinephrine .
NA
{ "id": "C0028351", "name": "norepinephrine", "pos": [ 171, 185 ] }
{ "id": "C0014563", "name": "epinephrine", "pos": [ 190, 201 ] }
in a wide survey on normal non-selected healthy adults , the authors have found normal phs in venous blood , a p50 slightly shifted to the left , in comparison with the mean values reported in other series for males and females , normal hb amounts , normal 2,3-dpg levels , normal met-hemoglobin values and increased rat...
NA
{ "id": "C0019046", "name": "hb", "pos": [ 237, 239 ] }
{ "id": "C0025635", "name": "met-hemoglobin", "pos": [ 281, 295 ] }
this antinociceptive activity is not mimicked by biogenic amine neurotransmitters ( i.e . norepinephrine , epinephrine , dopamine , serotonin or histamine ) and is not markedly affected by selective depletors of brain catecholamines or serotonin .
NA
{ "id": "C0028351", "name": "norepinephrine", "pos": [ 90, 104 ] }
{ "id": "C0014563", "name": "epinephrine", "pos": [ 107, 118 ] }
the morphological maturation of neurocytes of the cranial cervical ganglion during the 1st month of life was accompanied in rats by changes in the state of dna-histone chromatin complex and rise of stainability of non-histone nuclear proteins by fast green fcf at ph 2.6 .
NA
{ "id": "C0019652", "name": "histone", "pos": [ 160, 167 ] }
{ "id": "C0028589", "name": "nuclear", "pos": [ 226, 233 ] }
fracture itself may occur not only because of low bone mass but also because of other factors intrinsic to bone , such as accumulation of microdamage , or extrinsic to bone , such as poor coordination or frequency of trauma .
NA
{ "id": "C0016658", "name": "fracture", "pos": [ 0, 8 ] }
{ "id": "C0043251", "name": "trauma", "pos": [ 217, 223 ] }
using the ca/p ratio as criterion -- measured by the characteristic x-ray fluorescence -- it was shown in a blind study that the naf-treated otospongiotic stapes had a statistically higher ca/p ratio , indicating that the fluoride may stabilize otospongiotic lesions , particularly the spongiotic type with unstable mine...
NA
{ "id": "C0037508", "name": "naf", "pos": [ 129, 132 ] }
{ "id": "C0016327", "name": "fluoride", "pos": [ 222, 230 ] }
however , it is certain that adherence to a suitable life-style and good dietary habits tend to reduce the associated risk factors and compensates , at least in part , for the effects of hypotensive drugs on the lipids and lipoproteins .
NA
{ "id": "C0023779", "name": "lipids", "pos": [ 212, 218 ] }
{ "id": "C0023820", "name": "lipoproteins", "pos": [ 223, 235 ] }
this myelofibrosis is similar to that found in most of myeloproliferative disorders at some step of evolutivity .
NA
{ "id": "C0001815", "name": "myelofibrosis", "pos": [ 5, 18 ] }
{ "id": "C0027022", "name": "myeloproliferative disorders", "pos": [ 55, 83 ] }
a 24-item scale with five subscales was developed to measure the construct of maternal-fetal attachment during pregnancy and tested on 71 subjects in the third trimester of pregnancy .
NA
{ "id": "C0032961", "name": "pregnancy", "pos": [ 111, 120 ] }
{ "id": "C0032981", "name": "third trimester", "pos": [ 154, 169 ] }
incubation of purified enzyme with met-enkephalin-arg6-phe7 , a naturally occurring enkephalin surrogate , was accompanied by the release of three products as detected by reverse phase hplc .
NA
{ "id": "C0014295", "name": "met-enkephalin", "pos": [ 35, 49 ] }
{ "id": "C0014298", "name": "enkephalin", "pos": [ 84, 94 ] }
catecholamines , norepinephrine , epinephrine and dopamine were measured by electrochemical detection while the peptides , vasopressin , oxytocin , luteinizing hormone-releasing hormone ( lhrh ) , the enkephalins and somatostatin ( srif ) were measured by radioimmunoassay .
NA
{ "id": "C0028351", "name": "norepinephrine", "pos": [ 17, 31 ] }
{ "id": "C0014563", "name": "epinephrine", "pos": [ 34, 45 ] }
these features have not previously been reported as side effects of glibenclamide therapy , but intrahepatic cholestasis may occur with chlorpropamide , a similar sulphonylurea agent .
NA
{ "id": "C0017628", "name": "glibenclamide", "pos": [ 68, 81 ] }
{ "id": "C0038766", "name": "sulphonylurea", "pos": [ 163, 176 ] }
these features have not previously been reported as side effects of glibenclamide therapy , but intrahepatic cholestasis may occur with chlorpropamide , a similar sulphonylurea agent .
NA
{ "id": "C0008287", "name": "chlorpropamide", "pos": [ 136, 150 ] }
{ "id": "C0038766", "name": "sulphonylurea", "pos": [ 163, 176 ] }
inhibiting effect of natural hormones on the labelled uridine incorporation into thymocyte rna decreased as follows : dehydrocortisone greater than progesterone greater than pregnanediol greater than aldosterone greater than pregnenolone greater than 11-doc greater than cortexolone greater than methyltestosterone great...
NA
{ "id": "C0033308", "name": "progesterone", "pos": [ 148, 160 ] }
{ "id": "C0033004", "name": "pregnanediol", "pos": [ 174, 186 ] }
inhibiting effect of natural hormones on the labelled uridine incorporation into thymocyte rna decreased as follows : dehydrocortisone greater than progesterone greater than pregnanediol greater than aldosterone greater than pregnenolone greater than 11-doc greater than cortexolone greater than methyltestosterone great...
NA
{ "id": "C0025826", "name": "methyltestosterone", "pos": [ 296, 314 ] }
{ "id": "C0039601", "name": "testosterone", "pos": [ 465, 477 ] }
inhibiting effect of natural hormones on the labelled uridine incorporation into thymocyte rna decreased as follows : dehydrocortisone greater than progesterone greater than pregnanediol greater than aldosterone greater than pregnenolone greater than 11-doc greater than cortexolone greater than methyltestosterone great...
NA
{ "id": "C0045010", "name": "17 alpha-hydroxyprogesterone", "pos": [ 351, 379 ] }
{ "id": "C0033007", "name": "pregnanetriol", "pos": [ 491, 504 ] }
the paper is concerned with the results of the studies on corticosteroid kinetics ( secretion rate , distribution volume , metabolic blood clearance , mean daily blood cortisol content and excretion of free hormone with urine ) in 44 patients suffering from icenko-cushing 's disease , treated with chloditane and/or chl...
NA
{ "id": "C0001617", "name": "corticosteroid", "pos": [ 58, 72 ] }
{ "id": "C0019932", "name": "hormone", "pos": [ 207, 214 ] }
radioimmunoassays were used to study in experiments on sacred baboons the circadian rhythms of dehydrocortisone , 11-deoxycortisol , progesterone , pregnenolone and 17-hydroxypregnenolone in the folliculin and luteal phases of the menstrual cycle .
NA
{ "id": "C0373704", "name": "pregnenolone", "pos": [ 148, 160 ] }
{ "id": "C0376260", "name": "17-hydroxypregnenolone", "pos": [ 165, 187 ] }
the circadian rhythms of pregnenolone and 17-hydroxypregnenolone secretion were not pronounced in the folliculin phase .
NA
{ "id": "C0373704", "name": "pregnenolone", "pos": [ 25, 37 ] }
{ "id": "C0376260", "name": "17-hydroxypregnenolone", "pos": [ 42, 64 ] }
two of the four repeated dna sequences near the 5 ' end of the silk fibroin gene hybridize with discrete-length families of repeated dna .
NA
{ "id": "C0074529", "name": "silk", "pos": [ 63, 67 ] }
{ "id": "C0016042", "name": "fibroin", "pos": [ 68, 75 ] }
we demonstrate that poly ( da-dt ) can adopt two conformations in solution , with the relative proportions dependent on the nature and concentration of the counter ion and cationic ligands .
NA
{ "id": "C0022023", "name": "ion", "pos": [ 58, 61 ] }
{ "id": "C0007447", "name": "cationic", "pos": [ 172, 180 ] }
analysis by electron microscopy shows that t7 dna polymerase [ dna nucleotidyltransferase ( dna-directed ) , ec 2.7.7.7 ] and gene 4 protein initiate dna synthesis at randomly located nicks on duplex dna to produce branched molecules .
NA
{ "id": "C0012892", "name": "dna", "pos": [ 46, 49 ] }
{ "id": "C0012882", "name": "dna nucleotidyltransferase", "pos": [ 63, 89 ] }
comparison of the proteins of two immunologically distinct intermediate-sized filaments by amino acid sequence analysis : desmin and vimentin .
NA
{ "id": "C0021769", "name": "proteins", "pos": [ 18, 26 ] }
{ "id": "C0042666", "name": "vimentin", "pos": [ 133, 141 ] }
selected hybridomas were found to produce monoclonal antibodies specific for aflatoxin b1-modified dna containing both the 2,3-dihydro-2- ( n7-guanyl ) -3-hydroxyaflatoxin b1 and the putative 2,3-dihydro-2- ( n5-formyl-2',5',6'-triamino-4'oxo-n5-pyrimidyl ) -3-hydroxyaflatoxin b1 , suggesting that these dna adducts sha...
NA
{ "id": "C0012854", "name": "dna", "pos": [ 99, 102 ] }
{ "id": "C0242958", "name": "dna adducts", "pos": [ 305, 316 ] }
the [ 3h ] -diprenorphine binding observed in the presence of morphiceptin and [ d-ala2 , d-leu5 ] enkephalin exhibits high affinity for several benzomorphan drugs in the chemical family of 6,7-benzomorphan ( e.g. , cyclazocine , ethylketocyclazocine , skf 10047 , um 1072 , oxilorphan , etc ) .
NA
{ "id": "C0010526", "name": "cyclazocine", "pos": [ 216, 227 ] }
{ "id": "C0079314", "name": "ethylketocyclazocine", "pos": [ 230, 250 ] }
using a recently isolated human basic somatomedin ( basic sm ) similar to insulin-like growth factor i ( igf-i ) , we studied both the photoaffinity-labeled and unlabeled basic-sm receptor solubilized from human placental cell membranes .
NA
{ "id": "C0037657", "name": "somatomedin", "pos": [ 38, 49 ] }
{ "id": "C0021665", "name": "igf-i", "pos": [ 105, 110 ] }
our data suggest that , compared with the sequence of viral dna in the large circular form of unintegrated viral dna , the provirus lacks two base pairs at each end and that the provirus is flanked by a six-base-pair direct repeat of cellular dna .
NA
{ "id": "C0012939", "name": "viral dna", "pos": [ 54, 63 ] }
{ "id": "C0012854", "name": "dna", "pos": [ 243, 246 ] }
our data suggest that , compared with the sequence of viral dna in the large circular form of unintegrated viral dna , the provirus lacks two base pairs at each end and that the provirus is flanked by a six-base-pair direct repeat of cellular dna .
NA
{ "id": "C0012925", "name": "circular", "pos": [ 77, 85 ] }
{ "id": "C0012854", "name": "dna", "pos": [ 243, 246 ] }
[ 3h ] leucine-labeled hit insulin and proinsulin were identical to islet-derived proteins when compared by nadodso4/polyacrylamide gel electrophoresis of immunoprecipitates .
NA
{ "id": "C0021641", "name": "insulin", "pos": [ 27, 34 ] }
{ "id": "C0033362", "name": "proinsulin", "pos": [ 39, 49 ] }
avian retroviral dna molecules that had been cloned from infected cells by using recombinant dna techniques were microinjected into either uninfected chicken embryo fibroblasts ( cef ) or cef transformed by the envelope glycoprotein-deficient bryan strain of rous sarcoma virus [ rsv ( -- ) cells ] .
NA
{ "id": "C0016030", "name": "cef", "pos": [ 179, 182 ] }
{ "id": "C0007634", "name": "cells", "pos": [ 291, 296 ] }
membrane destruction by complement is effected by the membrane attack complex ( mac ) which is the dimer of a fusion product of the complement proteins c5b , c6 , c7 , c8 , and c9 .
NA
{ "id": "C0009498", "name": "complement", "pos": [ 24, 34 ] }
{ "id": "C0009545", "name": "membrane attack complex", "pos": [ 54, 77 ] }
twenty-three structural analogs of the leukotriene components of slow reacting substance of anaphylaxis ( srs-a ) , in which the polar regions of the leukotriene were systematically modified , were tested for their contractile activities on guinea pig pulmonary parenchymal strips and guinea pig ileum .
NA
{ "id": "C0038091", "name": "of", "pos": [ 32, 34 ] }
{ "id": "C0023545", "name": "leukotriene", "pos": [ 150, 161 ] }
they did not react with bronchioloalveolar and large cell lung cancers , myeloma , lymphomas , leukemias , osteogeneic sarcoma , mesothelioma , hypernephroma , malignant melanoma , simian virus 40-transformed human fetal lung cells , skin fibroblast lines , human b-lymphoblastoid lines , human erythrocytes , and rodent...
NA
{ "id": "C0016030", "name": "fibroblast", "pos": [ 239, 249 ] }
{ "id": "C0007634", "name": "cells", "pos": [ 321, 326 ] }
some results from storage experiments at +4 degrees c with adenine and purine nucleosides in this laboratory are compared with incubation experiments at 37 degrees c with guanosine at ph 7.0 and 7.4 and different levels of inorganic phosphate ( ip ) .
NA
{ "id": "C0034136", "name": "purine", "pos": [ 71, 77 ] }
{ "id": "C0018330", "name": "guanosine", "pos": [ 171, 180 ] }
studies in erythroid cultures have uncovered the phenomenon of asynchrony of hb f and hb a synthesis during the maturation of erythroblasts and have been used to investigate models of commitment to f cell formation .
NA
{ "id": "C0015936", "name": "hb f", "pos": [ 77, 81 ] }
{ "id": "C0019046", "name": "hb", "pos": [ 86, 88 ] }
in general the culture of the erythroid progenitor cells offers opportunities to ask questions about regulation of hb f to hb a switching and to get answers which are relevant to regulation in vivo .
NA
{ "id": "C0015936", "name": "hb f", "pos": [ 115, 119 ] }
{ "id": "C0019046", "name": "hb", "pos": [ 123, 125 ] }
a chromatography of hemoglobins on biorex 70 has been devised very recently to overcome the two limitations of ief : first the contamination of fetal blood samples by maternal cells , and second the impossibility to evaluate hb a when present in proportion below 1 % .
NA
{ "id": "C0019016", "name": "a", "pos": [ 0, 1 ] }
{ "id": "C0019046", "name": "hb", "pos": [ 225, 227 ] }
both naloxone and a structurally-related congener , naltrexone ( 0.01-10 mg/kg ) , attenuated water consumption is a dose-related fashion of 1 hr water-deprived homozygotes , which exhibit a complete absence of vasopressin .
NA
{ "id": "C0027358", "name": "naloxone", "pos": [ 5, 13 ] }
{ "id": "C0027360", "name": "naltrexone", "pos": [ 52, 62 ] }
saralasin infusions in cla rats resulted in a dramatic increase of plasma angiotensin ii concentrations .
NA
{ "id": "C0036193", "name": "saralasin", "pos": [ 0, 9 ] }
{ "id": "C0003009", "name": "angiotensin ii", "pos": [ 74, 88 ] }
subsequently rats were challenged with amph at behaviorally relevant doses and times and striatal and mesolimbic dopamine ( da ) dynamics were assessed using the conversion of 3h-tyrosine to 3h-da , and endogenous levels of da and its metabolites 3,4-dihydroxyphenylacetic acid ( dopac ) and homovanillic acid ( hva ) as...
NA
{ "id": "C0013030", "name": "da", "pos": [ 124, 126 ] }
{ "id": "C0282151", "name": "dopaminergic", "pos": [ 332, 344 ] }
administration of catecholamine-depleting drugs ( alpha-methyl-p-tyrosine , disulfiram or dopa ) , on the other hand , had no effect .
NA
{ "id": "C0007412", "name": "catecholamine", "pos": [ 18, 31 ] }
{ "id": "C0013023", "name": "dopa", "pos": [ 90, 94 ] }
a tlc method for measurement of aminophenazone ( 1 ) and of its degradation products 4-methylaminophenazone ( 2 ) and 4-aminophenazone ( 3 ) in plasma was described .
NA
{ "id": "C0002586", "name": "aminophenazone", "pos": [ 32, 46 ] }
{ "id": "C0002696", "name": "4-aminophenazone", "pos": [ 118, 134 ] }
first , there is metabolism by the hepatic microsomal mixed-function oxidase ( mfo ) enzyme system , the most important component of which is cytochrome p-450 .
NA
{ "id": "C0003927", "name": "microsomal mixed-function oxidase", "pos": [ 43, 76 ] }
{ "id": "C0010762", "name": "cytochrome p-450", "pos": [ 142, 158 ] }
the most effective 3 or 4-drug combinations contain cisplatin , vinblastine , bleomycin , adriamycin , cyclophosphamide , ifosfamide and vepesid .
NA
{ "id": "C0010583", "name": "cyclophosphamide", "pos": [ 103, 119 ] }
{ "id": "C0020823", "name": "ifosfamide", "pos": [ 122, 132 ] }
we found 14 neural tube defects ( nine spina bifida , four anencephaly , one meckel syndrome ) , four abdominal wall defects , two tumors , and eight normal examinations .
NA
{ "id": "C0027794", "name": "neural tube defects", "pos": [ 12, 31 ] }
{ "id": "C0002902", "name": "anencephaly", "pos": [ 59, 70 ] }
after 60 min the slices were transferred into fresh buffer with the corresponding pg-concentration and 3h-labelled proline or hydroxyproline .
NA
{ "id": "C0033382", "name": "proline", "pos": [ 115, 122 ] }
{ "id": "C0020388", "name": "hydroxyproline", "pos": [ 126, 140 ] }
it was concluded that competitive binding between albumin and soluble liver proteins , is important in the hepatic uptake of warfarin .
NA
{ "id": "C0001924", "name": "albumin", "pos": [ 50, 57 ] }
{ "id": "C0033684", "name": "proteins", "pos": [ 76, 84 ] }
the strategy for derivation of monoclonal antibodies requires careful consideration of factors such as the initial immunization with antigen , choice of myeloma cell line , and method of assay for the desired antibodies .
NA
{ "id": "C0003250", "name": "monoclonal antibodies", "pos": [ 31, 52 ] }
{ "id": "C0003241", "name": "antibodies", "pos": [ 209, 219 ] }
the effect of indomethacin and naproxen on collagen metabolism was studied in arthritic animals after an injection of [ 3h ] -proline , both the specific and total radioactivity of [ 3h ] -hydroxyproline being determined in skin collagen fractions and in urine .
NA
{ "id": "C0033382", "name": "proline", "pos": [ 126, 133 ] }
{ "id": "C0020388", "name": "hydroxyproline", "pos": [ 189, 203 ] }
comparison of serum salicylate levels and gastro-intestinal blood loss between salsalate ( disalcid ) and other forms of salicylates .
NA
{ "id": "C0073983", "name": "salsalate", "pos": [ 79, 88 ] }
{ "id": "C0036077", "name": "salicylates", "pos": [ 121, 132 ] }
the acetylator phenotype status was studied in 61 patients with rheumatoid arthritis ( ra ) , of whom 27 had associated sjogren 's syndrome ( ss ) .
NA
{ "id": "C0003873", "name": "rheumatoid", "pos": [ 64, 74 ] }
{ "id": "C1527336", "name": "sjogren 's syndrome", "pos": [ 120, 139 ] }
in ra patients with ss , however , the frequency of slow acetylators was as great as 78 % , while it was only 44 % among patients without ss ( p less than 0.02 ) .
NA
{ "id": "C0003873", "name": "ra", "pos": [ 3, 5 ] }
{ "id": "C1527336", "name": "ss", "pos": [ 147, 149 ] }
thus , there appears to exist a ( pharmaco ) genetic difference between ra patients with and without ss .
NA
{ "id": "C0003873", "name": "ra", "pos": [ 72, 74 ] }
{ "id": "C1527336", "name": "ss", "pos": [ 101, 103 ] }
in addition , toxicodermias were found to be more frequent in ra patients with than without ss ( p less than 0.01 ) .
NA
{ "id": "C0003873", "name": "ra", "pos": [ 62, 64 ] }
{ "id": "C1527336", "name": "ss", "pos": [ 101, 103 ] }
[ incidence and clinical manifestation of acth-producing pituitary adenoma after bilateral adrenalectomy for cushing 's syndrome ( nelson syndrome ) ] .
NA
{ "id": "C1306214", "name": "acth-producing pituitary adenoma", "pos": [ 42, 74 ] }
{ "id": "C0027577", "name": "nelson syndrome", "pos": [ 131, 146 ] }
120 strains of candida spp were tested against the antifungal agents 5-fluorocytosine , amphotericine b and the imidazoles econazole , miconazole and clotrimazole .
NA
{ "id": "C0020924", "name": "imidazoles", "pos": [ 112, 122 ] }
{ "id": "C0013547", "name": "econazole", "pos": [ 123, 132 ] }
120 strains of candida spp were tested against the antifungal agents 5-fluorocytosine , amphotericine b and the imidazoles econazole , miconazole and clotrimazole .
NA
{ "id": "C0020924", "name": "imidazoles", "pos": [ 112, 122 ] }
{ "id": "C0025942", "name": "miconazole", "pos": [ 135, 145 ] }
120 strains of candida spp were tested against the antifungal agents 5-fluorocytosine , amphotericine b and the imidazoles econazole , miconazole and clotrimazole .
NA
{ "id": "C0020924", "name": "imidazoles", "pos": [ 112, 122 ] }
{ "id": "C0009074", "name": "clotrimazole", "pos": [ 150, 162 ] }
adverse reactions ( urticaria , angio-edema , bronchoconstriction , purpura ) to aspirin ( ass ) and food-and-drug additives such as the yellow dye tartrazine and the preservative benzoate are observed all over the world .
NA
{ "id": "C0042109", "name": "urticaria", "pos": [ 20, 29 ] }
{ "id": "C0002994", "name": "angio-edema", "pos": [ 32, 43 ] }
fibroblasts contain a specific internalization pathway that carries hormones as well as some proteins and viruses from the cell surface to the cell interior .
NA
{ "id": "C0016030", "name": "fibroblasts", "pos": [ 0, 11 ] }
{ "id": "C0007634", "name": "cell", "pos": [ 143, 147 ] }
the number of tumors was significantly smaller in rats given drinking water containing indomethacin ( beginning 14 days after the injections ) than in control rats given drug-free water .
NA
{ "id": "C0599638", "name": "drinking water", "pos": [ 61, 75 ] }
{ "id": "C0043047", "name": "water", "pos": [ 180, 185 ] }
translationally active ( in xenopus oocytes ) human alpha interferon ( ifn ) messenger rna 's ( mrna 's ) derived from sendai virus -- induced leukocyte cultures display a bimodal distribution of rna lengths on electrophoresis through agarose-ch3hgoh gels .
NA
{ "id": "C0035696", "name": "messenger rna 's", "pos": [ 77, 93 ] }
{ "id": "C0035668", "name": "rna", "pos": [ 196, 199 ] }
analysis of cultured fibroblasts and lymphoblasts from 12 affected members of a large kindred showed a mean concentration of intracellular inorganic pyrophosphate two times greater than that in cells from unaffected family members or normal , unrelated volunteers .
NA
{ "id": "C0016030", "name": "fibroblasts", "pos": [ 21, 32 ] }
{ "id": "C0007634", "name": "cells", "pos": [ 194, 199 ] }
the use of electron microscopy has permitted a good understanding of these elements and a recognition of ubiquitous cells ( fibroblasts , endothelial cells ) and specific cells to the lymph node which seem to play a very important role in the immune reactions ( interdigitated cells , reticulum cells , dendritic cells )...
NA
{ "id": "C0016030", "name": "fibroblasts", "pos": [ 124, 135 ] }
{ "id": "C0007634", "name": "cells", "pos": [ 313, 318 ] }
human synthetic insulin may possibly be responsible for allergies similar to those which occur with monocomponent insulin .
NA
{ "id": "C0795635", "name": "human", "pos": [ 0, 5 ] }
{ "id": "C0021641", "name": "insulin", "pos": [ 114, 121 ] }
the five main causes of impairment were burns , trauma , congenital defects , cerebral palsy , and cerebrovascular accident .
NA
{ "id": "C0006434", "name": "burns", "pos": [ 40, 45 ] }
{ "id": "C0043251", "name": "trauma", "pos": [ 48, 54 ] }
the two ribose-positive variants used differed phenotypically in their ability to use pentoses other than ribose for growth .
NA
{ "id": "C0030894", "name": "pentoses", "pos": [ 86, 94 ] }
{ "id": "C0035549", "name": "ribose", "pos": [ 106, 112 ] }
each variant was fused to pentose-negative parental hepatoma cells , and resultant hybrids were tested for the ability to use ribose .
NA
{ "id": "C0030894", "name": "pentose", "pos": [ 26, 33 ] }
{ "id": "C0035549", "name": "ribose", "pos": [ 126, 132 ] }
we have used normal diploid human skin fibroblasts , monkey bsc cells , and mouse l or 3t6 cells with almost equal efficiency .
NA
{ "id": "C0016030", "name": "fibroblasts", "pos": [ 39, 50 ] }
{ "id": "C0007634", "name": "cells", "pos": [ 91, 96 ] }
in cell hybrids between nonpermissive don/a23 cells and human fibroblasts containing a t ( 11 ; 15 ) ( p11 ; p12 ) translocation , hsv-1 production was dependent solely on the presence of either human chromosome 11 or the der ( 11 ) ( p11 leads to qter ) translocation product containing the long arm of chromosome 11 .
NA
{ "id": "C0007634", "name": "cells", "pos": [ 46, 51 ] }
{ "id": "C0016030", "name": "fibroblasts", "pos": [ 62, 73 ] }