text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
a deficiency of lip activity has been observed in wolman 's disease ( wd ) , cholesterol ester storage disease ( cesd ) , and i-cell disease ( icd ) ; | NA | {
"id": "C0043208",
"name": "wolman 's disease",
"pos": [
50,
67
]
} | {
"id": "C0008384",
"name": "cholesterol ester storage disease",
"pos": [
77,
110
]
} |
previous evidence suggested the different mutations associated with wd and cesd to be in the structural gene which we assign to human chromosome 10 , while a different gene , involved in the processing of lipa , is altered in icd . | NA | {
"id": "C0043208",
"name": "wd",
"pos": [
68,
70
]
} | {
"id": "C0008384",
"name": "cesd",
"pos": [
75,
79
]
} |
stable mutants resistant to the toxic anion chromate have been isolated from a variety of chinese hamster cell lines . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
38,
43
]
} | {
"id": "C0008543",
"name": "chromate",
"pos": [
44,
52
]
} |
[ early caries in the deciduous teeth of infants and young children : acute caries in children can be avoided by better parent education ] . | NA | {
"id": "C0728836",
"name": "young children",
"pos": [
53,
67
]
} | {
"id": "C0008059",
"name": "children",
"pos": [
86,
94
]
} |
effects of superoxide dismutase on lipopolysaccharide-stressed mice and alteration of lung enzyme levels by endotoxin . | NA | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
35,
53
]
} | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
108,
117
]
} |
estrogen administration to ovariectomized rats on normal diet resulted in increased reductase activity and was correlated with decreased serum cholesterol and increased liver cholesterol levels with mestranol ( me ) , ethinyl estradiol ( ee ) and estradiol benzoate ( eb , 250 microgram ) but increased serum and liver c... | NA | {
"id": "C0025506",
"name": "mestranol",
"pos": [
199,
208
]
} | {
"id": "C0015011",
"name": "ethinyl estradiol",
"pos": [
218,
235
]
} |
results from testosterone treated rats were especially significant : the hormone administration decreased the stores of dopamine and norepinephrine ( epinephrine precursors ) , stimulated pnmt and decreased metabolism of epinephrine by mao and comt . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
133,
147
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
221,
232
]
} |
als-treated b10.a recipients were transfused either with donor-specific b10.d2 blood or blood from b10.br which shares the minor histocompatibility antigens with b10.d2 , but differs in the major antigens or dba/2 blood which shares the majority histocompatibility antigens with b10.d2 , but differs in the minor antigen... | NA | {
"id": "C0026189",
"name": "minor",
"pos": [
123,
128
]
} | {
"id": "C0019628",
"name": "histocompatibility antigens",
"pos": [
246,
273
]
} |
their peripheral blood mononuclear cells showed an increased relative response ( rr ) to cells from hla-identical siblings as compared to cells from normal hla-identical siblings , confirming the results reported in an earlier series of 34 patients . | NA | {
"id": "C1321301",
"name": "peripheral blood mononuclear cells",
"pos": [
6,
40
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
138,
143
]
} |
the transforming activity was revealed in a specific fragment of the viral dna , obtained after the treatment of the dna with bamhi ( fragment b ) , with molecular weight 5.4 x 10 ( 6 ) dalton . | NA | {
"id": "C0012939",
"name": "viral dna",
"pos": [
69,
78
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
117,
120
]
} |
the lack of cell transformation by the ecori-hydrolysate of viral dna may serve a proof of the extremely left position of the oncogene in the viral genome , since of ecori-fragment chips off a fragment with molecular weight 3 x 10 ( 5 ) dalton fr om the left side of dna molecule . | NA | {
"id": "C0012939",
"name": "viral dna",
"pos": [
60,
69
]
} | {
"id": "C0012854",
"name": "dna molecule",
"pos": [
267,
279
]
} |
application of gel filtration through sephadex g-100 ( ph 7,5 ) and ion-exchange chromatography on km-sephadex g-50 ( ph 7.2 ) made it possible to detect high-active proteolytic enzymes : elastase-like esterases and serine proteinases in the granular fraction of polymorphonuclear leucocytes of pig peripheral blood . | NA | {
"id": "C0030940",
"name": "proteolytic enzymes",
"pos": [
166,
185
]
} | {
"id": "C2717971",
"name": "serine proteinases",
"pos": [
216,
234
]
} |
ultrastructurally , the mass was composed of fibroblast-like , histiocyte-like , and multinucleated giant cells , and some undifferentiated cells and mononuclear cells intermediate between the fibroblast-like and histiocyte-like cells . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
45,
55
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
229,
234
]
} |
dogs given both pyridoxine hydrochloride and clioquinol had a combination of the lesions in dogs given pyridoxine or clioquinol individually . | NA | {
"id": "C0700496",
"name": "pyridoxine hydrochloride",
"pos": [
16,
40
]
} | {
"id": "C0034272",
"name": "pyridoxine",
"pos": [
103,
113
]
} |
ninety-five sick calves were given either glucose-glycine electrolyte solution orally ( 41 calves ) or the electrolyte solution in combination with an antibacterial agent ( 54 calves ) to compare the efficacy of these treatments . | NA | {
"id": "C0013832",
"name": "electrolyte",
"pos": [
58,
69
]
} | {
"id": "C0308944",
"name": "electrolyte solution",
"pos": [
107,
127
]
} |
inhibition of functions of the anticoagulation system , caused by long-term atherogenic diet in the animals , led to inhibition of the initial steps of heparin clearance as well as to alteration of the glycosaminoglycan distribution in various tissues . | NA | {
"id": "C0019134",
"name": "heparin",
"pos": [
152,
159
]
} | {
"id": "C0017973",
"name": "glycosaminoglycan",
"pos": [
202,
219
]
} |
the rate of synthesis of rna10-65 degrees , total and non-histone proteins was increased in liver and kidney tissues , while the synthesis of these proteins and rna was unaltered in spleen tissue . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
66,
74
]
} | {
"id": "C0034861",
"name": "synthesis",
"pos": [
129,
138
]
} |
the immobilized enzyme exhibited the ph optimum of activity displaced by one ph unit to the acid side as compared with the free enzyme . | NA | {
"id": "C0014444",
"name": "immobilized enzyme",
"pos": [
4,
22
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
128,
134
]
} |
unlike normal subjects , oral administration of calcium pantothenate ( 50 ng ) to patients with hepatitis results in a decrease of the excretion of the free form of pa . | NA | {
"id": "C0006710",
"name": "calcium pantothenate",
"pos": [
48,
68
]
} | {
"id": "C0030342",
"name": "pa",
"pos": [
165,
167
]
} |
[ effect of a magnesium-enriched diet on electrolyte metabolism and oxalate excretion in kidney diseases in children ] . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
53,
63
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
76,
85
]
} |
the diet enriched with food having a high content of magnesium and group b vitamins ( wheat bran , buckwheat , oatmeal , millet , dried apricots , yeast ) was used in a comprehensive treatment of patients with renal diseases accompanied by hyperoxaluria . | NA | {
"id": "C0022658",
"name": "renal diseases",
"pos": [
210,
224
]
} | {
"id": "C0020500",
"name": "hyperoxaluria",
"pos": [
240,
253
]
} |
it was established that experimental myocardial infarction leads to a decrease in the ascorbic acid content in the left heart ventricle in the ischemic are and to a negligible rise in the dehydroascorbic acid concentration within the first hours after artery ligation followed by its lowering at the 24th hour . | NA | {
"id": "C0003968",
"name": "ascorbic acid",
"pos": [
86,
99
]
} | {
"id": "C0011177",
"name": "dehydroascorbic acid",
"pos": [
188,
208
]
} |
meanwhile 24 hours after the operation the right heart ventricle manifests a 22 % increase in the ascorbic acid content along with the rise of the deketogulonic acid level , whereas the content of dehydroascorbic acid does not appreciably change . | NA | {
"id": "C0003968",
"name": "ascorbic acid",
"pos": [
98,
111
]
} | {
"id": "C0011177",
"name": "dehydroascorbic acid",
"pos": [
197,
217
]
} |
[ comparative study of the action of amantadine ( 1-aminoadamantane ) and remantadine ( alpha-methyl-1-adamantane methylamine ) hydrochloride on influenza virus a reproduction ] . | NA | {
"id": "C0002403",
"name": "1-aminoadamantane",
"pos": [
50,
67
]
} | {
"id": "C0001392",
"name": "adamantane",
"pos": [
103,
113
]
} |
[ comparative study of the action of amantadine ( 1-aminoadamantane ) and remantadine ( alpha-methyl-1-adamantane methylamine ) hydrochloride on influenza virus a reproduction ] . | NA | {
"id": "C0035629",
"name": "remantadine",
"pos": [
74,
85
]
} | {
"id": "C0001392",
"name": "adamantane",
"pos": [
103,
113
]
} |
absorption , excretion , tissue distribution and metabolism of the anthraquinone [ 14c ] emodin was studied after a single oral administration ( approx . 50 mg/kg ) to rats . | NA | {
"id": "C0221102",
"name": "excretion",
"pos": [
13,
22
]
} | {
"id": "C0025519",
"name": "metabolism",
"pos": [
49,
59
]
} |
the conjugate , s- ( pentachlorophenyl ) glutathione , is further metabolized by cleavage of the glutamate and glycine results and acetylation of the amino group of the cysteinyl moiety , to give the mercapturic acid n-acetyl-s- ( pentachlorophenyl ) cysteine , a major metabolite of hcb and pcnb in rats and rabbits res... | NA | {
"id": "C0001047",
"name": "mercapturic acid",
"pos": [
200,
216
]
} | {
"id": "C0010654",
"name": "cysteine",
"pos": [
251,
259
]
} |
bile secreted from rats given single oral doses of 2-chloro-n-isopropylacetanilide ( propachlor ) contained 58 % dose as metabolites from the mercapturic acid pathway ( glutathione , mercapturate , cysteine conjugates , and a sulphoxide of the mercapturate ) . | NA | {
"id": "C0001047",
"name": "mercapturic acid",
"pos": [
142,
158
]
} | {
"id": "C0010654",
"name": "cysteine",
"pos": [
198,
206
]
} |
in addition , new markers for sccl have been identified , such as a creatine kinase and its bb isoenzyme ( ck-bb ) . | NA | {
"id": "C0010287",
"name": "creatine kinase",
"pos": [
68,
83
]
} | {
"id": "C0010289",
"name": "ck-bb",
"pos": [
107,
112
]
} |
[ alveolitis and fibrosis of the lung within the drainage area of a hospital for diseases of the lung ( author 's transl ) ] . | NA | {
"id": "C0034069",
"name": "fibrosis of",
"pos": [
17,
28
]
} | {
"id": "C0024115",
"name": "diseases of the lung",
"pos": [
81,
101
]
} |
a case of of angioimmunoblastic lymphadenopathy is presented , a recently described lymphoproliferative disorder with an increasing incidence . | NA | {
"id": "C0020981",
"name": "angioimmunoblastic lymphadenopathy",
"pos": [
13,
47
]
} | {
"id": "C0024314",
"name": "lymphoproliferative disorder",
"pos": [
84,
112
]
} |
12 patients with cardiac tumors ( 7 myxomas of the left , 2 of the right atrium , 2 ventricular , 2 intramural tumors and 1 epicardial cyst ) were examined by m-mode- ( me ) and two-dimensional ( 2de ) echocardiography , computertomography ( ct ) and heart catheterization ( hk ) with angiography ( a ) . | NA | {
"id": "C0027651",
"name": "tumors",
"pos": [
25,
31
]
} | {
"id": "C0010709",
"name": "cyst",
"pos": [
135,
139
]
} |
with me all atrial myxomas were diagnosed , but 2 ventricular and 2 intramural tumors as well as the epicardial cyst were overlooked . | NA | {
"id": "C0027651",
"name": "tumors",
"pos": [
79,
85
]
} | {
"id": "C0010709",
"name": "cyst",
"pos": [
112,
116
]
} |
also with hk and a , the 2 intramural tumors and the epicardial cyst were not recognized well . | NA | {
"id": "C0027651",
"name": "tumors",
"pos": [
38,
44
]
} | {
"id": "C0010709",
"name": "cyst",
"pos": [
64,
68
]
} |
a group of epileptic patients in whom the seizures were accompanied with false sensations was examined . | NA | {
"id": "C0014544",
"name": "epileptic",
"pos": [
11,
20
]
} | {
"id": "C0036572",
"name": "seizures",
"pos": [
42,
50
]
} |
in patients suffering from tick-borne encephalitis development of epileptic seizures , kozhevnikov 's epilepsy , jackson 's epilepsy , myoclonus-epilepsy , chorea-epilepsy hunt 's myoclonic dyssynergy and various hyperkineses without general convulsions was observed . | NA | {
"id": "C0014550",
"name": "myoclonus-epilepsy",
"pos": [
135,
153
]
} | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
163,
171
]
} |
results of studying the electrographic cortical and subcortical correlates of temporal epilepsy seizures in 23 patients with complicated forms of the disease are presented . | NA | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
87,
95
]
} | {
"id": "C0036572",
"name": "seizures",
"pos": [
96,
104
]
} |
seizures of automatism , temporal pseudo-absences , vegetovisceral and polymorphic focal attacks took their course with synchronized epileptic activity in the cortical and limbic structures . | NA | {
"id": "C0036572",
"name": "seizures",
"pos": [
0,
8
]
} | {
"id": "C0014544",
"name": "epileptic",
"pos": [
133,
142
]
} |
clinical and clinico-pathoanatomical comparisons ( 60 observations ) have shown that in patients with primary cutaneous melanoma and its metastases treated by modern methods the tumour metastasis to the brain occurs in late periods of the disease at the stage of the neoplastic process generalization . | NA | {
"id": "C0027627",
"name": "metastases",
"pos": [
137,
147
]
} | {
"id": "C0027671",
"name": "neoplastic process",
"pos": [
267,
285
]
} |
these tumors are bilateral renal cystic displasia ( rp ) rare hamartomas , p.e . angiomyolipomas , and malignant neoplasms , p.e . renal clear cell carcinomas . | NA | {
"id": "C0027651",
"name": "tumors",
"pos": [
6,
12
]
} | {
"id": "C0018552",
"name": "hamartomas",
"pos": [
62,
72
]
} |
the authors studied the effect of a new anti-arrhythmic agent , the cibenzoline in 9 patients suffering from numerous ventricular extrasystoles ( on average 8 extrasystoles/minute ) . | NA | {
"id": "C0151636",
"name": "ventricular extrasystoles",
"pos": [
118,
143
]
} | {
"id": "C0340464",
"name": "extrasystoles",
"pos": [
159,
172
]
} |
efficacy was considered to be excellent in 3 cases ( complete disappearance of extrasystoles ) good in 3 cases ( more than 90 % decrease in the number of extrasystoles ) and poor in 3 cases ( these concerned two patients also resistant to all other anti-arrhythmic agents and one patient with an extreme variability of h... | NA | {
"id": "C0340464",
"name": "extrasystoles",
"pos": [
79,
92
]
} | {
"id": "C0003811",
"name": "arrhythmia",
"pos": [
323,
333
]
} |
significant increases in plasma norepinephrine and plasma epinephrine concentrations were observed in response to methacholine administration with significant haemodynamic changes , but there was no correlation between the rise in plasma catecholamines and the haemodynamic changes . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
32,
46
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
58,
69
]
} |
the effects of insulin hypoglycaemia ( 0.15 iu/kg ) on plasma adrenaline , noradrenaline , dopamine , glucagon and pancreatic polypeptide ( pp ) concentrations were investigated in 6 adrenalectomized subjects and 6 healthy controls . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
62,
72
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
75,
88
]
} |
as expected , epinephrine and norepinephrine levels did not increase in adx patients and , accordingly , blood pressure did not change . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
14,
25
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
30,
44
]
} |
the urinary excretion of the diamines histamine , methylhistamine , putrescine and cadaverine and the polyamines spermidine and spermine was studied in rats which on the 19th day of pregnancy were subjected to various ectomizing operations . | NA | {
"id": "C0011957",
"name": "diamines",
"pos": [
29,
37
]
} | {
"id": "C0032433",
"name": "polyamines",
"pos": [
102,
112
]
} |
removal of both the foetuses and placentae reduced the excretion of putrescine , cadaverine and spermidine towards the level of non-pregnant rats . | NA | {
"id": "C0034170",
"name": "putrescine",
"pos": [
68,
78
]
} | {
"id": "C0037871",
"name": "level",
"pos": [
119,
124
]
} |
saliva and plasma concentrations of norethisterone ( net ) were determined by a radioimmunoassay in 5 healthy women and in one epileptic woman on phenytoin treatment during a 21-day cycle on an oral contraceptive containing 3 mg net-acetate and 0.05 mg ethinyloestradiol . | NA | {
"id": "C0028356",
"name": "norethisterone",
"pos": [
36,
50
]
} | {
"id": "C0068980",
"name": "net-acetate",
"pos": [
229,
240
]
} |
possible synthesis of pregnancy-'specific ' beta-1-glycoprotein ( sp1 ) and placenta-'specific ' tissue proteins ( pp10 , pp12 ) by human and cynomolgus monkey leukocytes . | NA | {
"id": "C0033002",
"name": "pregnancy",
"pos": [
22,
31
]
} | {
"id": "C0032974",
"name": "placenta",
"pos": [
76,
84
]
} |
such evidence consisted of increased staining intensity for the enzyme glucose-6-phosphate dehydrogenase and for the nucleic acids rna and dna . | NA | {
"id": "C0028606",
"name": "nucleic acids",
"pos": [
117,
130
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
139,
142
]
} |
the fact that not only apomorphine but also haloperidol stimulated cortisol release suggests a complex role or dopamine transmission involving different dopaminergic pathways as well as different dopamine receptors . | NA | {
"id": "C0013030",
"name": "dopamine",
"pos": [
111,
119
]
} | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
153,
165
]
} |
a radioimmunoassay method suitable for measuring levels of b-endorphin , b-lipotropin and proopiocortin in tissue and plasma extracts was developed and the method was evaluated by using 3 independently prepared antisera . | NA | {
"id": "C0023832",
"name": "lipotropin",
"pos": [
75,
85
]
} | {
"id": "C0033195",
"name": "proopiocortin",
"pos": [
90,
103
]
} |
it was found that both pituitary and plasma contain significant amounts of proopiocortin , b-lipotropin and b-endorphin , the molar proportions being 10:33:57 in pituitary and 15:15:17 in plasma , respectively . | NA | {
"id": "C0033195",
"name": "proopiocortin",
"pos": [
75,
88
]
} | {
"id": "C0023832",
"name": "lipotropin",
"pos": [
93,
103
]
} |
in kidneys with experimental neoplasm , the flow reduction was proportionally less in the tumor than in intact renal tissue . | NA | {
"id": "C0027659",
"name": "experimental neoplasm",
"pos": [
16,
37
]
} | {
"id": "C0027651",
"name": "tumor",
"pos": [
90,
95
]
} |
na+ k+-adenosine triphosphatase ( atpase ) , 5 ' nucleotidase ( 5'nd ) and gamma-glutamyl transpeptidase ( gamma-gtp ) did not show any decrease in activity in the cona-cb-bleb fraction , but the activity of d+-stimulated phosphatase ( k-pase ) was decreased . | NA | {
"id": "C0001479",
"name": "na",
"pos": [
0,
2
]
} | {
"id": "C0001473",
"name": "atpase",
"pos": [
34,
40
]
} |
collagen synthesis was lower in scleroderma fibroblasts than in normal cells , whereas there was no difference in sulfated glycosaminoglycans synthesis . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
44,
55
]
} | {
"id": "C0007634",
"name": "normal cells",
"pos": [
64,
76
]
} |
it is concluded that some patients with php retain calcium-sensitive secretion of pth , and that the classical calcium infusion test is of doubtful value in the diagnosis of php . | NA | {
"id": "C0221002",
"name": "php",
"pos": [
40,
43
]
} | {
"id": "C0020502",
"name": "php",
"pos": [
174,
177
]
} |
e ) cobalamins ( congenital intrinsic factor deficiency , cobalamin malabsorption , transcobalamin deficiency , methylmalonic aciduria ) f ) folic acid ( congenital folic acid malabsorption , formimino-transferase deficiency , methylenetetrahydrofolic reductase deficiency , lesch-nyhan syndrome ) ; | NA | {
"id": "C0086024",
"name": "cobalamins",
"pos": [
4,
14
]
} | {
"id": "C0042845",
"name": "cobalamin",
"pos": [
89,
98
]
} |
most of the soft drinks analyzed contain the monosaccharides glucose and fructose and the disaccharide sucrose . | NA | {
"id": "C0012611",
"name": "disaccharide",
"pos": [
90,
102
]
} | {
"id": "C0038636",
"name": "sucrose",
"pos": [
103,
110
]
} |
the rise in serum vitamin a 5 h after a 450 microgram oral dose of the vitamin ( retinyl palmitate ) was used to assess vitamin a nutriture in patients with alcoholic cirrhosis . | NA | {
"id": "C0073115",
"name": "retinyl palmitate",
"pos": [
81,
98
]
} | {
"id": "C0042839",
"name": "vitamin a",
"pos": [
120,
129
]
} |
by utilizing the fact that heparin and protamine sulfate directly neutralize each other , it is possible to quickly detect excess levels of protamine ( anti-heparin activity ) by back-titrating a plasma specimen with predetermined amounts of heparin . | NA | {
"id": "C0033602",
"name": "protamine sulfate",
"pos": [
39,
56
]
} | {
"id": "C0033603",
"name": "protamine",
"pos": [
140,
149
]
} |
chloramphenicol could be measured accurately in the presence of a variety of beta-lactam , aminoglycoside , sulfonamide , and tetracycline antimicrobial agents , but not cefoxitin or trimethoprim-sulfamethoxazole . | NA | {
"id": "C0002556",
"name": "aminoglycoside",
"pos": [
91,
105
]
} | {
"id": "C1136254",
"name": "antimicrobial agents",
"pos": [
139,
159
]
} |
it is suggested that the acute cholangitis could account for the jaundice and hyperbilirubinemia that is reported in about half the patients with tss . | NA | {
"id": "C0022346",
"name": "jaundice",
"pos": [
65,
73
]
} | {
"id": "C0020433",
"name": "hyperbilirubinemia",
"pos": [
78,
96
]
} |
although conjunctivitis was the most common clinical condition associated with h. influenza biotype iii , three cases of systemic infection with this organism are presented : a 10-month-old female with pneumonia , a 17-year-old male with sepsis , and a 7-year-old male with endophthalmitis . | NA | {
"id": "C0243026",
"name": "systemic infection",
"pos": [
121,
139
]
} | {
"id": "C0036690",
"name": "sepsis",
"pos": [
238,
244
]
} |
she was first observed in the newborn period with marked degree virilization and clinical findings suggestive of salt-losing congenital adrenal hyperplasia . | NA | {
"id": "C0042755",
"name": "virilization",
"pos": [
64,
76
]
} | {
"id": "C0037088",
"name": "clinical findings",
"pos": [
81,
98
]
} |
the neural tube defects ( anencephaly , encephalocele , spina bifida cystica ) , oral clefts ( cleft lip +/- palate , posterior cleft palate ) , omphalocele , and diaphragmatic hernia associate with one another far more frequently than at the expected random combination rates . | NA | {
"id": "C0027794",
"name": "neural tube defects",
"pos": [
4,
23
]
} | {
"id": "C0002902",
"name": "anencephaly",
"pos": [
26,
37
]
} |
no statistical relationship was found between sp-1 values at 31 to 34 weeks and birth weight , placental weight , parity , or other abnormal pregnancy outcomes . | NA | {
"id": "C0005612",
"name": "birth weight",
"pos": [
80,
92
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
105,
111
]
} |
2 ) increased total lipid accumulation was observed in mdv-infected smc , particularly cholesterol ( ch ) and cholesteryl esters ( ces ) , as compared with uninfected or hvt-infected cells ; | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
87,
98
]
} | {
"id": "C0008387",
"name": "cholesteryl",
"pos": [
110,
121
]
} |
animal model of human disease : mucopolysaccharidosis vi maroteaux-lamy syndrome , arylsulfatase b-deficient mucopolysaccharidosis in the siamese cat . | NA | {
"id": "C0026709",
"name": "maroteaux-lamy syndrome",
"pos": [
57,
80
]
} | {
"id": "C0026703",
"name": "mucopolysaccharidosis",
"pos": [
109,
130
]
} |
children less than 2 years of age did not differ from the older children nor did cyanotic children differ from the acyanotic children . | NA | {
"id": "C1455726",
"name": "older children",
"pos": [
58,
72
]
} | {
"id": "C0008059",
"name": "children",
"pos": [
125,
133
]
} |
in analogy to the immunological method for detecting the presence of cysticercosis in cattle we examined the applicability of the indirect immunofluorescence reaction as a technique for detecting taeniasis in man in 200 sera of tapeworm carriers and 150 sera of controls . | NA | {
"id": "C0010678",
"name": "cysticercosis",
"pos": [
69,
82
]
} | {
"id": "C0039254",
"name": "taeniasis",
"pos": [
196,
205
]
} |
in analogy to the immunological method for detecting the presence of cysticercosis in cattle we examined the applicability of the indirect immunofluorescence reaction as a technique for detecting taeniasis in man in 200 sera of tapeworm carriers and 150 sera of controls . | NA | {
"id": "C0039254",
"name": "taeniasis",
"pos": [
196,
205
]
} | {
"id": "C0007894",
"name": "tapeworm",
"pos": [
228,
236
]
} |
study of nutritional balance showed a deficiency in protein metabolism -- with hypoproteinaemia , hypoalbuminaemia , decrease in creatine index , negative nitrogen balance -- combined with a deficiency in trace elements . | NA | {
"id": "C0020639",
"name": "hypoproteinaemia",
"pos": [
79,
95
]
} | {
"id": "C0239981",
"name": "hypoalbuminaemia",
"pos": [
98,
114
]
} |
comparisons were made of cardiovascular effects in intact , awake , previously instrumented calves given the following oxytetracycline ( oxy ) preparations and components : polyvinylpyrrolidine vehicle ( pvp ) , oxy hcl in pvp ( oxy-pvp ) , oxy hcl ( usp ) in saline solution , propylene glycol , 77.8 % ( pg ) , propyle... | NA | {
"id": "C0017449",
"name": "oxy hcl",
"pos": [
212,
219
]
} | {
"id": "C0030092",
"name": "oxy",
"pos": [
369,
372
]
} |
in order to evaluate the ability of this method to determine changes in number of apud cells , rats were exposed to diethylnitrosamine ( den ) and nitrogen dioxide ( no2 ) , which have been reported to increase the number of airways apud cells . | NA | {
"id": "C0018956",
"name": "apud cells",
"pos": [
82,
92
]
} | {
"id": "C0007634",
"name": "the",
"pos": [
211,
214
]
} |
a study was done of 31 episodes of transient loss of consciousness occurring at the onset of 557 cerebral ischaemic events selected on the basis of a well known mode of onset , excluding prolonged comas . | NA | {
"id": "C0041657",
"name": "of",
"pos": [
17,
19
]
} | {
"id": "C0009421",
"name": "comas",
"pos": [
197,
202
]
} |
epilepsy accounts for nearly half ( 3.8 p. 100 ) of all losses of consciousness in hemispheric strokes , but was encountered neither in lacunar strokes nor in transient ischaemic attacks ( t.i.a . ) . | NA | {
"id": "C0038454",
"name": "strokes",
"pos": [
95,
102
]
} | {
"id": "C3178801",
"name": "lacunar",
"pos": [
136,
143
]
} |
it would seem that there is a lack of essential features that could separate pan from churg and strauss ' syndrome , the preexistence of an asthmatic state perhaps simply modifying the pan disorder in certain particular ways . | NA | {
"id": "C0039082",
"name": "syndrome",
"pos": [
106,
114
]
} | {
"id": "C0012634",
"name": "disorder",
"pos": [
189,
197
]
} |
factors o5 , o10 and o16 were subdivided , and a factor common to groups o2 and o3 was specified . | NA | {
"id": "C0030054",
"name": "o2",
"pos": [
73,
75
]
} | {
"id": "C0030106",
"name": "o3",
"pos": [
80,
82
]
} |
levels of serum cortisol and 11-deoxycortisol and of urinary 17-oh-corticosteroids and 17-ketosteroids were measured both before and after stimulation with metyrapone in ten normal adults . | NA | {
"id": "C0001617",
"name": "corticosteroids",
"pos": [
67,
82
]
} | {
"id": "C0000167",
"name": "17-ketosteroids",
"pos": [
87,
102
]
} |
the mic of benzylpenicillin , ampicillin , ceporin , streptomycin , kanamycin , gentamicin , tetracycline , rondomycin , rifampicin , chloramphenicol , nalidixic acid , orafuran , furacin and furazolidon with respect to e. coli strains isolated from urological patients were determined and compared with those isolated f... | NA | {
"id": "C0030827",
"name": "benzylpenicillin",
"pos": [
11,
27
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
30,
40
]
} |
cefoperazone ( 40 mg/kg ) administered every 6 h was significantly more effective than cefamandole ( 40 mg/kg ) administered every 6 h in reducing the number of enterobacter aerogenes cells in vegetations . | NA | {
"id": "C0007552",
"name": "cefoperazone",
"pos": [
0,
12
]
} | {
"id": "C0007541",
"name": "cefamandole",
"pos": [
87,
98
]
} |
although cefamandole produced higher peak concentrations in serum , the serum bactericidal activity was greater with cefoperazone . | NA | {
"id": "C0007541",
"name": "cefamandole",
"pos": [
9,
20
]
} | {
"id": "C0007552",
"name": "cefoperazone",
"pos": [
117,
129
]
} |
the half-lives in serum were 0.64 h for cefoperazone and 0.46 h for cephalothin and cefamandole . | NA | {
"id": "C0007552",
"name": "cefoperazone",
"pos": [
40,
52
]
} | {
"id": "C0007541",
"name": "cefamandole",
"pos": [
84,
95
]
} |
for serum-resistant clinical isolates of escherichia coli were grown in the presence of various subinhibitory concentrations of mecillinam or pivmecillinam and then exposed to the bactericidal action of human serum . | NA | {
"id": "C0002435",
"name": "mecillinam",
"pos": [
128,
138
]
} | {
"id": "C0002436",
"name": "pivmecillinam",
"pos": [
142,
155
]
} |
previous aminoglycoside treatment ( usually gentamicin ) had occurred more frequently in the tobramycin treated patients ( p less than 0.01 ) , and more males than females received tobramycin ( p less than 0.05 ) . | NA | {
"id": "C0002556",
"name": "aminoglycoside",
"pos": [
9,
23
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
44,
54
]
} |
the range in die-off times was encountered irrespective of the fecal coliform count in the applied effluent or the application regimen ( 125 to 1,000 kg of elemental nitrogen in the form of effluent per ha ; return periods , 3 to 12 months ) . | NA | {
"id": "C0013879",
"name": "elemental",
"pos": [
156,
165
]
} | {
"id": "C0028158",
"name": "nitrogen",
"pos": [
166,
174
]
} |
induction of passive monovalent cation-exchange activity in heart mitochondria by depletion of endogenous divalent cations . | NA | {
"id": "C0007447",
"name": "cation",
"pos": [
32,
38
]
} | {
"id": "C0007448",
"name": "divalent cations",
"pos": [
106,
122
]
} |
familial benign chronic pemphigus ( hailey and hailey disease ) is a rare , recalcitrant , often disabling genodermatosis that may not respond to conservative dermatologic therapy . | NA | {
"id": "C0085106",
"name": "hailey disease",
"pos": [
47,
61
]
} | {
"id": "C0037277",
"name": "genodermatosis",
"pos": [
107,
121
]
} |
two boys , both with adequate testosterone output on human chorionic gonadotrophin stimulation , were given gonadotrophin therapy , whereas the other 3 were treated with parenterally administered testosterone . | NA | {
"id": "C0018062",
"name": "human chorionic gonadotrophin",
"pos": [
53,
82
]
} | {
"id": "C0018061",
"name": "gonadotrophin",
"pos": [
108,
121
]
} |
although the mechanism of the hypogonadotropism remains unclear , the association of hypogonadotrophic hypogonadism with familial cytomegalic adrenocortical hypoplasia appears to be a constant one and may be considered as a treatable inherited syndrome of pubertal failure . | NA | {
"id": "C0020619",
"name": "hypogonadotropism",
"pos": [
30,
47
]
} | {
"id": "C0022735",
"name": "hypogonadotrophic hypogonadism",
"pos": [
85,
115
]
} |
the antibacterial activity of tobramycin , gentamicin , amikacin , sisomicin and kanamycin against 192 strains of genus proteus has been studied in vitro . | NA | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
43,
53
]
} | {
"id": "C0037209",
"name": "sisomicin",
"pos": [
67,
76
]
} |
the antibacterial activity of tobramycin , gentamicin , amikacin , sisomicin and kanamycin against 192 strains of genus proteus has been studied in vitro . | NA | {
"id": "C0002499",
"name": "amikacin",
"pos": [
56,
64
]
} | {
"id": "C0022487",
"name": "kanamycin",
"pos": [
81,
90
]
} |
antimelanoma antibody sources included human alloantibody obtained from melanoma patients immunized against allogeneic melanoma cells , a monkey antiserum raised by immunization against a single human melanoma cell line , and a murine monoclonal antimelanoma antibody-secreting hybridoma cell line . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
13,
21
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
145,
154
]
} |
antimelanoma antibody sources included human alloantibody obtained from melanoma patients immunized against allogeneic melanoma cells , a monkey antiserum raised by immunization against a single human melanoma cell line , and a murine monoclonal antimelanoma antibody-secreting hybridoma cell line . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
13,
21
]
} | {
"id": "C0003250",
"name": "monoclonal",
"pos": [
235,
245
]
} |
the second malformation arose on a situs inversus , atrioventricular concordance ( left sided loop ) and double outlet right ventricle . | NA | {
"id": "C0000768",
"name": "malformation",
"pos": [
11,
23
]
} | {
"id": "C0037221",
"name": "situs inversus",
"pos": [
35,
49
]
} |
this was monitored in 3 cyanotic neonates with ductal dependant cardiac malformations ( tricuspid atresia , transposition of the great arteries with atresia or severe stenosis of the pulmonary valve ) by continuous measurement of the cutaneous po2 . | NA | {
"id": "C0018798",
"name": "cardiac malformations",
"pos": [
64,
85
]
} | {
"id": "C0243002",
"name": "tricuspid atresia",
"pos": [
88,
105
]
} |
this was monitored in 3 cyanotic neonates with ductal dependant cardiac malformations ( tricuspid atresia , transposition of the great arteries with atresia or severe stenosis of the pulmonary valve ) by continuous measurement of the cutaneous po2 . | NA | {
"id": "C0018798",
"name": "cardiac malformations",
"pos": [
64,
85
]
} | {
"id": "C0040761",
"name": "transposition of the great arteries",
"pos": [
108,
143
]
} |
in rat central nervous system , 3h-prazosin and 3h-clonidine bind to two different classes of alpha-adrenoceptors : - 3h-prazosin binds to alpha1-adrenoceptors with high affinity ( kd 25 degrees c = 0.30 nm ) with a number of binding sites of 81.6 fmoles/mg of protein . | NA | {
"id": "C0034784",
"name": "alpha-adrenoceptors",
"pos": [
94,
113
]
} | {
"id": "C0001638",
"name": "alpha1-adrenoceptors",
"pos": [
139,
159
]
} |
14 cases of hypopituitarism associated with mid-line defects are reported : 7 with septo-optic dysplasia , 5 with agenesis of corpus callosum and septum pellucidum without optical lesion ( 2 with cleft palate ) , 1 with familial pituitary aplasia and 1 with mediofrontal cutaneous aplasia . | NA | {
"id": "C0020635",
"name": "hypopituitarism",
"pos": [
12,
27
]
} | {
"id": "C0032002",
"name": "pituitary",
"pos": [
229,
238
]
} |
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