text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
in all patients , clinical and biological symptoms were those of pulmonary hypertension with persistence of the fetal circulation . | NA | {
"id": "C0020542",
"name": "pulmonary hypertension",
"pos": [
65,
87
]
} | {
"id": "C0031190",
"name": "persistence",
"pos": [
93,
104
]
} |
all cases submitted as hodgkin 's disease ( hd ) were accepted as ml , but 13 % were reclassified as nhl . | NA | {
"id": "C0024299",
"name": "ml",
"pos": [
66,
68
]
} | {
"id": "C0024305",
"name": "nhl",
"pos": [
101,
104
]
} |
all reported fractures are reviewed regarding age , sex , trauma , fracture localization and type , neurologic complications and fracture healing . | NA | {
"id": "C0043251",
"name": "trauma",
"pos": [
58,
64
]
} | {
"id": "C0016658",
"name": "fracture",
"pos": [
129,
137
]
} |
[ concentration of urea in blood , a parameter for the assessment of protein metabolism of pregnant sows . 1. development of the concentration of urea in blood after the intake of proteins and its relation to n-excretion in urine ] . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
77,
87
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
211,
220
]
} |
in addition , electrophoretic mobility of 32p labeled virus rnas varied for certain uk isolates and indicated heterogeneity in genes 2 , 3 , 4 and 8 coding for polymerase proteins 2 and 1 , nucleoprotein ( np ) and non-structural protein ( ns 1 ) respectively . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
171,
179
]
} | {
"id": "C0028612",
"name": "nucleoprotein",
"pos": [
190,
203
]
} |
the use of calcium sulfate ( plaster of paris ) has been advocated to repair bony defects because of its unique capability of stimulating osteoneogenesis . | NA | {
"id": "C0006720",
"name": "calcium sulfate",
"pos": [
11,
26
]
} | {
"id": "C0032160",
"name": "plaster of paris",
"pos": [
29,
45
]
} |
the arterial influx of esterified and free cholesterol from low density lipoproteins and very low density lipoproteins in 20 hypercholesterolemic rabbits was measured simultaneously by the use of lipoproteins labeled in vivo with [ 3h ] - and [ 14c ] -cholesterol . | NA | {
"id": "C0023824",
"name": "cholesterol",
"pos": [
43,
54
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
252,
263
]
} |
the arterial influx of esterified and free cholesterol from low density lipoproteins and very low density lipoproteins in 20 hypercholesterolemic rabbits was measured simultaneously by the use of lipoproteins labeled in vivo with [ 3h ] - and [ 14c ] -cholesterol . | NA | {
"id": "C0023825",
"name": "very low density lipoproteins",
"pos": [
89,
118
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
196,
208
]
} |
the purpose of this study was to determine whether the free cholesterol of hypercholesterolemic low density lipoprotein from cholesterol-fed nonhuman primates has a greater potential for surface transfer to cell membranes than does the free cholesterol of normal low density lipoprotein . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
60,
71
]
} | {
"id": "C0023824",
"name": "cholesterol",
"pos": [
241,
252
]
} |
since these membranes neither synthesize nor esterify cholesterol , nor degrade the protein or cholesterol ester moieties of low density lipoprotein , they are an ideal model with which to study differences in the cholesterol transfer potential of low density lipoprotein independent of the uptake of the intact low dens... | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
54,
65
]
} | {
"id": "C0023824",
"name": "cholesterol",
"pos": [
214,
225
]
} |
levels of apolipoprotein a-1 and apolipoprotein a-11 , the major apoproteins of high density lipoproteins , were assayed by radioimmunoassay . | NA | {
"id": "C0085201",
"name": "apolipoprotein a-1",
"pos": [
10,
28
]
} | {
"id": "C0003592",
"name": "apolipoprotein a",
"pos": [
33,
49
]
} |
we have developed a procedure for labeling lipoproteins with the fluorescent probe 3,3'-dioctadecylindocarbocyanine ( dil ) and have used dil-labeled native and acetoacetylated lipoproteins to differentiate macrophages from fibroblasts in mixed cell culture . | NA | {
"id": "C0065058",
"name": "a",
"pos": [
4,
5
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
177,
189
]
} |
in both pigeon groups , aortic gag included 8 % hyaluronic acid , 11 % dermatan sulfate , 15 % heparan sulfate , and 66 % chondroitin sulfate . | NA | {
"id": "C0017973",
"name": "gag",
"pos": [
31,
34
]
} | {
"id": "C0019143",
"name": "heparan sulfate",
"pos": [
95,
110
]
} |
cholesterol-rich extracts from human adrenal glands and liver did not stimulate cholesteryl ester formation in macrophages . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
0,
11
]
} | {
"id": "C0008387",
"name": "cholesteryl ester",
"pos": [
80,
97
]
} |
in three cows injected intramuscularly with 20 mg dexamethasone sodium phosphate the concentrations of dexamethasone in plasma rose sharply to maximum levels of 24-70 ng/ml within 2-20 min after injection and fell to undetectable levels ( less than 0.15 ng/ml ) after 72 hr . | NA | {
"id": "C0113286",
"name": "dexamethasone sodium phosphate",
"pos": [
50,
80
]
} | {
"id": "C0011777",
"name": "dexamethasone",
"pos": [
103,
116
]
} |
pregnancy-associated hypertension developed in the third trimester in 26 pregnant women but they had the-same degree of elevation of serum c3 and c4 levels as did the 147 pregnant women who remained normotensive throughout their pregnancy . | NA | {
"id": "C0032981",
"name": "third trimester",
"pos": [
51,
66
]
} | {
"id": "C0032961",
"name": "pregnancy",
"pos": [
229,
238
]
} |
in the first experiment imdp was seen to be at least as effective in reducing t. sergenti parasitaemias as primaquine phosphate ( primaquine ) , the drug normally used on the island . | NA | {
"id": "C0033128",
"name": "primaquine phosphate",
"pos": [
107,
127
]
} | {
"id": "C0033126",
"name": "primaquine",
"pos": [
130,
140
]
} |
the latter technique compares favourably with the use of other natural prostaglandins and prostaglandin analogues . | NA | {
"id": "C0033554",
"name": "prostaglandins",
"pos": [
71,
85
]
} | {
"id": "C0033568",
"name": "prostaglandin analogues",
"pos": [
90,
113
]
} |
a gene locus is described controlling liver activities in the house mouse of three glycosidases , i.e. , beta-galactosidase , beta-glucuronidase , and n-acetyl-beta-hexosaminidase . | NA | {
"id": "C0017976",
"name": "glycosidases",
"pos": [
83,
95
]
} | {
"id": "C0017776",
"name": "beta-glucuronidase",
"pos": [
126,
144
]
} |
a quantitative selected-ion monitoring method for the determination of plasma concentrations of the new potent antiallergic agent , 4- ( p-chlorobenzyl ) -2- ( hexahydro-1-methyl-1h-azepin-4-yl ) -1- ( 2h ) -phthalazinone hydrochloride ( azelastine hydrochloride , a 5610 ) , using n-methyl deuterium labelled azelastine... | NA | {
"id": "C0771004",
"name": "azelastine hydrochloride",
"pos": [
238,
262
]
} | {
"id": "C0052762",
"name": "internal",
"pos": [
328,
336
]
} |
general pharmacological properties of uft , a new type of anti-cancer agent consisting of 1- ( 2-tetrahydrofuryl ) -5-fluorouracil ( ft ) and uracil . | NA | {
"id": "C0016360",
"name": "5-fluorouracil",
"pos": [
116,
130
]
} | {
"id": "C0041917",
"name": "uracil",
"pos": [
142,
148
]
} |
the pharmacological properties of a new type of anti-cancer agent , 1- ( 2-tetrahydrofuryl ) -5-fluorouracil ( ft ) and uracil ( u ) , in a molar ratio of 1:4 , were investigated and compared with those of ft , 5-fluorouracil ( 5-fu ) and uracil . | NA | {
"id": "C0016360",
"name": "5-fu",
"pos": [
228,
232
]
} | {
"id": "C0041917",
"name": "uracil",
"pos": [
239,
245
]
} |
like cefotaxime and cefoxitin , the compound proved to be a potent inhibitor of cephalosporinases but not of broad spectrum beta-lactamases . | NA | {
"id": "C0728805",
"name": "cephalosporinases",
"pos": [
80,
97
]
} | {
"id": "C0597979",
"name": "beta-lactamases",
"pos": [
124,
139
]
} |
in these trials , a 1 % solution of 6-cyclohexyl-1-hydroxy-4-methyl-2 ( 1h ) -pyridone , 2-aminoethanol salt ( ciclopiroxolamine , cic , hoe 296 , batrafen ) was compared with a 1 % solution of tolnaftate ( 2 studies ) and clotrimazole ( 1 study ) , respectively , and a 1 % cic cream was compared with a 1 % clotrimazol... | NA | {
"id": "C0009074",
"name": "clotrimazole",
"pos": [
223,
235
]
} | {
"id": "C0975746",
"name": "1",
"pos": [
305,
306
]
} |
our study seems to indicate that dietetic fibers exercise a vital role in regulating the concentration of plasma lipids even if the subject continues to consume a diet rich in fats . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
113,
119
]
} | {
"id": "C0015677",
"name": "fats",
"pos": [
176,
180
]
} |
antagonism of the respiratory effects of alfentanil and fentanyl by naloxone in the conscious rabbit . | NA | {
"id": "C0002026",
"name": "alfentanil",
"pos": [
41,
51
]
} | {
"id": "C0015846",
"name": "fentanyl",
"pos": [
56,
64
]
} |
naloxone was more effective as an antagonist to alfentanil than as an antagonist to fentanyl . | NA | {
"id": "C0002026",
"name": "alfentanil",
"pos": [
48,
58
]
} | {
"id": "C0015846",
"name": "fentanyl",
"pos": [
84,
92
]
} |
local venous reactions during and after the injection i.v . of diazepam in oil ( diazemuls ) and the water-soluble benzodiazepine midazolam ( dormicum ) were studied in 100 patients undergoing gastroscopy . | NA | {
"id": "C0005064",
"name": "benzodiazepine",
"pos": [
115,
129
]
} | {
"id": "C0026056",
"name": "midazolam",
"pos": [
130,
139
]
} |
1 relationship between plasma catecholamines ( measured as noradrenaline and adrenaline ) and plasma renin activity ( pra ) were examined at rest and during passive head-up tilting for 30 min in nine normal subjects , before and after treatment with propranolol 160 mg daily for 7 days . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
59,
72
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
77,
87
]
} |
a double blind comparison of talampicillin and ampicillin in the treatment of exacerbations of chronic bronchitis in general practice . | NA | {
"id": "C0039266",
"name": "talampicillin",
"pos": [
29,
42
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
47,
57
]
} |
heat inactivation abrogated the arginase and cytotoxicity , revealing heat-stable mitogenicity for fs6 cells and normal fibroblasts . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
103,
108
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
120,
131
]
} |
sixty patients with fairly stable asthma of mild or moderate severity entered a multicentre , double-blind cross-over trial , comparing the efficacy of inhaled beclomethasone dipropionate preceded 10 minutes earlier by inhalation of salbutamol with that of beclomethasone followed 10 minutes later by salbutamol during t... | NA | {
"id": "C0004906",
"name": "beclomethasone dipropionate",
"pos": [
160,
187
]
} | {
"id": "C0004905",
"name": "beclomethasone",
"pos": [
257,
271
]
} |
a substantial proportion ( 20-50 % ) of radioactive sugar incorporated into glycoconjugates by normal human keratinocytes was soluble in chloroform-methanol ; | NA | {
"id": "C0007004",
"name": "sugar",
"pos": [
52,
57
]
} | {
"id": "C0017906",
"name": "glycoconjugates",
"pos": [
76,
91
]
} |
three patients are described who developed angio-oedema and urticaria after a hot bath challenge and physical exercise . | NA | {
"id": "C0002994",
"name": "angio-oedema",
"pos": [
43,
55
]
} | {
"id": "C0042109",
"name": "urticaria",
"pos": [
60,
69
]
} |
twenty-nine of these animals were subjected to haemolytic stress and the magnitude of their hb f response was positively correlated with the resting hb f levels . | NA | {
"id": "C0019046",
"name": "hb",
"pos": [
92,
94
]
} | {
"id": "C0015936",
"name": "hb f",
"pos": [
149,
153
]
} |
these data demonstrate that the resting level of hb f is predictive of the magnitude of the hb f response to stress erythropoiesis . | NA | {
"id": "C0015936",
"name": "hb f",
"pos": [
49,
53
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
92,
94
]
} |
guanidino compounds with an aromatic group inhibit native phosphorylase b , reduced phosphorylase b , phosphorylase b ' , and phosphorylase a . | NA | {
"id": "C0031711",
"name": "phosphorylase b",
"pos": [
58,
73
]
} | {
"id": "C0017916",
"name": "phosphorylase",
"pos": [
126,
139
]
} |
the magnesium-dependent phosphorylation of sarcoplasmic reticulum ( ca2+ ) -atpase by inorganic phosphate ( mg2+ + pi + e = mg.e-p ) was studied in purified leaky atpase vesicles as a function of temperature ( 20-30 degrees c ) . | NA | {
"id": "C0001476",
"name": "ca2",
"pos": [
68,
71
]
} | {
"id": "C0001473",
"name": "atpase",
"pos": [
163,
169
]
} |
only 10-20 % of the determinants recognized by these antisera are accessible to antibodies when the receptor is membrane bound . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
53,
61
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
80,
90
]
} |
the unusual transfer ribonucleic acid ( rna ) anticodon adjacent modified nucleoside n- [ ( 9-beta-d-ribofuranosylpurin-6-yl ) carbamoyl ] threonine , t6a , and its n6-methyl ( mt6a ) and 5'-phosphate ( pt6a ) derivatives are efficient ligands for magnesium and manganese ions , as demonstrated by potentiometry and nucl... | NA | {
"id": "C0035711",
"name": "transfer ribonucleic acid",
"pos": [
12,
37
]
} | {
"id": "C0003284",
"name": "anticodon",
"pos": [
46,
55
]
} |
in vivo labeling of regenerating livers showed a continuous association of newly replicated dna with dna-rich matrices ( greater than or equal to 80 % of total labeled dna ) which is independent of the pulse period ( 1 min to 4 h ) . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
9,
10
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
168,
171
]
} |
dna-rich nuclear matrices may therefore provide a useful in vitro system for studying dna replication in correlation with the higher order , intranuclear arrangement of eukaryotic dna . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
2,
3
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
180,
183
]
} |
the enzymatic oxidation was selective for the alpha-methine bridge , and the alpha-biliverdins obtained were reduced by biliverdin reductase to the corresponding alpha-bilirubins . | NA | {
"id": "C0005446",
"name": "biliverdins",
"pos": [
83,
94
]
} | {
"id": "C0005437",
"name": "bilirubins",
"pos": [
168,
178
]
} |
in the second experimental system , ( na , k ) -atpase purified from rectal glands of squalus acanthias was reconstituted with defined phosphatidylcholines as the lipid solvent and spin-labeled phospholipids with choline or serine head groups ( pc* , ps* ) as the solute . | NA | {
"id": "C1959616",
"name": "phosphatidylcholines",
"pos": [
135,
155
]
} | {
"id": "C0031617",
"name": "phospholipids with choline",
"pos": [
194,
220
]
} |
lipid lateral diffusion in the surface membrane of cells and in multibilayers formed from plasma membrane lipids . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
0,
5
]
} | {
"id": "C0025249",
"name": "plasma membrane lipids",
"pos": [
90,
112
]
} |
distance from the 3 ' end of 16s ribonucleic acid to three points on phenylalanine-accepting transfer ribonucleic acid in the donor site of 70s ribosomes . | NA | {
"id": "C0035668",
"name": "ribonucleic acid",
"pos": [
33,
49
]
} | {
"id": "C0035711",
"name": "transfer ribonucleic acid",
"pos": [
93,
118
]
} |
5'-terminal cap structures of oligo ( uridylic acid ) -containing messenger ribonucleic acid from hela cells : comparison with other ribonucleic acid subpopulations . | NA | {
"id": "C0035696",
"name": "messenger",
"pos": [
66,
75
]
} | {
"id": "C0035668",
"name": "ribonucleic acid",
"pos": [
133,
149
]
} |
in addition , cytidine and uridine 3'- ( s-methyl phosphorothioates ) are substrates for bovine pancreatic ribonuclease and guanosine 3'- ( s-methyl phosphorothioate ) is a substrate for rnase t1 and rnase u1 . | NA | {
"id": "C0035541",
"name": "pancreatic ribonuclease",
"pos": [
96,
119
]
} | {
"id": "C0014241",
"name": "rnase",
"pos": [
200,
205
]
} |
in addition , cytidine and uridine 3'- ( s-methyl phosphorothioates ) are substrates for bovine pancreatic ribonuclease and guanosine 3'- ( s-methyl phosphorothioate ) is a substrate for rnase t1 and rnase u1 . | NA | {
"id": "C0018364",
"name": "rnase t1",
"pos": [
187,
195
]
} | {
"id": "C0014241",
"name": "rnase",
"pos": [
200,
205
]
} |
the inhibitor also binds to the enzyme-4a-peroxydihydroflavin complex to block the binding of the aldehyde substrate , while binding of the aldehyde substrate to either the free enzyme or the enzyme-4a-peroxydihydroflavin complex blocks binding of 2,2-diphenylpropylamine . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
32,
38
]
} | {
"id": "C0026741",
"name": "enzyme",
"pos": [
192,
198
]
} |
nadh and nad+ markedly protected both activities from inactivation , and the substrate steroids , estrone , estradiol , progesterone , and 20 alpha-hydroxy-4-pregnen-3-one , conferred similar protection , though less than cofactor , against simultaneous loss of both activities . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
120,
132
]
} | {
"id": "C0012311",
"name": "20",
"pos": [
139,
141
]
} |
the assignment of particular proteins to specific transitions is reinforced by selective extraction of membrane proteins . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
29,
37
]
} | {
"id": "C0025252",
"name": "membrane proteins",
"pos": [
103,
120
]
} |
of the total 3h ] labeled glycosaminoglycans produced by the melanocyte culture , 42 % was in chondroitin 4-sulfate , 25 % in heparan sulfate , 16 % in chondroitin 6-sulfate , and 17 % in hyaluronic acid . | NA | {
"id": "C0017973",
"name": "glycosaminoglycans",
"pos": [
26,
44
]
} | {
"id": "C0019143",
"name": "heparan sulfate",
"pos": [
126,
141
]
} |
binding curves of tropomyosin-troponin [ consisting of all three subunits ( holotroponin ) ] and of tropomyosin-troponin-t-i to actin filaments were analyzed by separating the affinity of tropomyosin-troponin for actin filaments and the affinity for the end-to-end contact of tropomyosin molecules . | NA | {
"id": "C0077404",
"name": "troponin-t",
"pos": [
112,
122
]
} | {
"id": "C0041199",
"name": "troponin",
"pos": [
200,
208
]
} |
the oxidant appeared to be o2 , rather than peroxide , superoxide , hydroxyl radical , or singlet oxygen . | NA | {
"id": "C0031180",
"name": "peroxide",
"pos": [
44,
52
]
} | {
"id": "C0038836",
"name": "superoxide",
"pos": [
55,
65
]
} |
purified mp-1 and mp-2 contained an above average content of hydrophobic amino acids , while mp-2 and mp-3 had an above average content of acid and/or amide amino acids and a below average content of basic amino acids . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
73,
84
]
} | {
"id": "C0301714",
"name": "basic amino acids",
"pos": [
200,
217
]
} |
the specificity of the binding of fmet-leu-phe was suggested by the failure of mp-2 and mp-3 to bind lipid chemotactic factors and to adhere to a sepaharose column to which had been coupled chemotactic fragments of the fifth component of complement . | NA | {
"id": "C0027229",
"name": "fmet-leu-phe",
"pos": [
34,
46
]
} | {
"id": "C0008013",
"name": "chemotactic factors",
"pos": [
107,
126
]
} |
the binding of monoclonal antibody 5.5.g.12 to acetylcholine receptor was inhibited by alpha-neurotoxins and by other cholinergic ligands in accordance with their affinities to the nicotinic acetylcholine receptor . | NA | {
"id": "C0034792",
"name": "acetylcholine receptor",
"pos": [
47,
69
]
} | {
"id": "C0034830",
"name": "nicotinic acetylcholine receptor",
"pos": [
181,
213
]
} |
the participation of primary amino groups of succinate dehydrogenase in the formation of succinate-q reductase . | NA | {
"id": "C0038615",
"name": "succinate dehydrogenase",
"pos": [
45,
68
]
} | {
"id": "C0283592",
"name": "succinate-q reductase",
"pos": [
89,
110
]
} |
this indicates that the inhibitory effect of fluorescamine on succinate dehydrogenase is due to the modification of a specific amino group ( s ) on succinate dehydrogenase which is essential in the interaction with qps to form succinate-q reductase . | NA | {
"id": "C0038615",
"name": "succinate dehydrogenase",
"pos": [
62,
85
]
} | {
"id": "C0283592",
"name": "succinate-q reductase",
"pos": [
227,
248
]
} |
the participation of an ionic group in the formation of succinate-q reductase supports the idea of the involvement of ionic interaction between succinate dehydrogenase and qps . | NA | {
"id": "C0283592",
"name": "succinate-q reductase",
"pos": [
56,
77
]
} | {
"id": "C0038615",
"name": "succinate dehydrogenase",
"pos": [
144,
167
]
} |
furthermore , we demonstrated the presence in quiescent cells of an na+-dependent transport system for neutral amino acids that has been characterized as system asc by several criteria including intolerance to methylaminoisobutyric acid , strict na+-dependence , the property of transtimulation and specificity for perti... | NA | {
"id": "C0301715",
"name": "neutral amino acids",
"pos": [
103,
122
]
} | {
"id": "C0036720",
"name": "serine",
"pos": [
354,
360
]
} |
furthermore , we demonstrated the presence in quiescent cells of an na+-dependent transport system for neutral amino acids that has been characterized as system asc by several criteria including intolerance to methylaminoisobutyric acid , strict na+-dependence , the property of transtimulation and specificity for perti... | NA | {
"id": "C0301715",
"name": "neutral amino acids",
"pos": [
103,
122
]
} | {
"id": "C0010654",
"name": "cysteine",
"pos": [
363,
371
]
} |
no3- , i- , and the thiocyanate anion were all ineffective substitutes for cl- whereas br- and acetate were only partially effective . | NA | {
"id": "C0021966",
"name": "i",
"pos": [
7,
8
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
32,
37
]
} |
the effect is observed in normal fibroblasts , ldl receptor deficient fibroblasts or in tunicamycin-treated cells with a reduced number of functional receptors but is dependent on the time of preincubation of the cells and the concentration of the sphingolipid in the medium . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
33,
44
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
213,
218
]
} |
our results indicate that ( a ) even though ionic surfactants induce both swelling and shape alterations in erythrocytes these two changes are not necessarily connected , and that ( b ) the different shapes induced by cationic and anionic surfactants can not be due to differences in the distribution of the surfactant m... | NA | {
"id": "C0022023",
"name": "ionic",
"pos": [
44,
49
]
} | {
"id": "C0007447",
"name": "cationic",
"pos": [
218,
226
]
} |
this difference in sensitivity to membrane lipids order suggests that internal and external cationic sites , although borne by the same protein , are in different lipid environments . | NA | {
"id": "C0025249",
"name": "membrane lipids",
"pos": [
34,
49
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
163,
168
]
} |
diagnosis of mycobacterium bovis and mycobacterium paratuberculosis infections in cattle by in vitro lymphocyte immunostimulation . | NA | {
"id": "C0026918",
"name": "mycobacterium",
"pos": [
13,
26
]
} | {
"id": "C0030524",
"name": "paratuberculosis",
"pos": [
51,
67
]
} |
they had less than 60 % gamma globulin with 3 % albumin and had fluorescein to protein ( f/p ) ratios of less than 10 . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
48,
55
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
79,
86
]
} |
because irradiation is not always readily available , 5-iodo-2-deoxyuridine ( iudr ) treatment of cells was investigated as a substitute procedure . | NA | {
"id": "C0011535",
"name": "deoxyuridine",
"pos": [
63,
75
]
} | {
"id": "C0020811",
"name": "iudr",
"pos": [
78,
82
]
} |
serum pneumococcal antibody was found to reside predominantly in the immunoglobulin g or immunoglobulin m classes , whereas pneumococcal antibody with middle-ear fluid was found to be distributed equally among all three classes . | NA | {
"id": "C0020852",
"name": "immunoglobulin g",
"pos": [
69,
85
]
} | {
"id": "C0021017",
"name": "immunoglobulin",
"pos": [
89,
103
]
} |
this antibody was primarily of the immunoglobulin a class as demonstrated by specific antiglobulin augmentation and gel filtration of antibody activity . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
5,
13
]
} | {
"id": "C0021017",
"name": "immunoglobulin",
"pos": [
35,
49
]
} |
comparison of these spectra to those of hemoglobin , methemoglobin , cytochrome c , and model cobalt porphyrin complexes suggests that the displacement of the cobalt atom upon oxygenation of cohb is no greater than the out-of-plane distance in five-coordinate co ( ii ) porphyrins , 0.15 a . | NA | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
40,
50
]
} | {
"id": "C0025635",
"name": "methemoglobin",
"pos": [
53,
66
]
} |
the four amelanotic variants that we have examined to date all behaved similarly : they lost basal tyrosinase ( ec 1.14.18.1 ; monophenol monooxygenase ) activity but retained melanocyte stimulating hormone-inducible activity ; | NA | {
"id": "C0012524",
"name": "tyrosinase",
"pos": [
99,
109
]
} | {
"id": "C0041484",
"name": "monophenol",
"pos": [
127,
137
]
} |
the binding of magnesium ions and of the competitive inhibitor 3-phospho-d-glyceric acid to yeast enolase ( 2-phospho-d-glycerate hydrolyase , ec 4.2.1.11 ) has been studied calorimetrically . | NA | {
"id": "C0031691",
"name": "enolase",
"pos": [
98,
105
]
} | {
"id": "C0020239",
"name": "hydrolyase",
"pos": [
130,
140
]
} |
phosphorylation of a protein ( or proteins ) of molecular weight 120,000 in the aplysia abdominal ganglion , as measured by incorporation of [ ( 32 ) p ] or [ ( 33 ) p ] sodium phosphate in vitro followed by separation of the phosphoproteins on sodium dodecyl sulfate-polyacrylamide gels , was specifically stimulated by... | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
34,
42
]
} | {
"id": "C0031689",
"name": "phosphoproteins",
"pos": [
226,
241
]
} |
however , under mild denaturing conditions which result in the conversion of viral 60s rna to 30s and smaller forms , all the globin sequences sediment as 9s rna . | NA | {
"id": "C0035736",
"name": "viral",
"pos": [
77,
82
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
158,
161
]
} |
results of hybridization experiments done at different dna/rna ratios suggest that although the virus-specific dna is partly unique and partly reiterated , the viral rna does not contain any detectable internal reiteration . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
59,
62
]
} | {
"id": "C0035736",
"name": "viral rna",
"pos": [
160,
169
]
} |
the messenger rna sequences are detected by measurement of the ability of the transcribed rna to hybridize with globin complementary dna . | NA | {
"id": "C0035696",
"name": "messenger rna",
"pos": [
4,
17
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
90,
93
]
} |
simian virus 40 dna sequences in dna of healthy adult mice derived from preimplantation blastocysts injected with viral dna . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
16,
19
]
} | {
"id": "C0012939",
"name": "viral dna",
"pos": [
114,
123
]
} |
while catalyzing the hydrolysis of a wide variety of phosphomonoesters , the enzyme has k ( m ) values for adenosine 5'-monophosphate and adenosine 3'-monophosphate in the micromolar range and appears highly specific for 5'- and 3'-ribonucleoside monophosphates as substrates at ph 5.0 . | NA | {
"id": "C0001413",
"name": "adenosine",
"pos": [
107,
116
]
} | {
"id": "C0001465",
"name": "adenosine",
"pos": [
138,
147
]
} |
since the cyclic nucleotide competitive inhibitors are also active growth promoters of higher plants , and , furthermore , since elevation of cyclic amp levels appears to be a consequence of some phytohormone treatments that promote plant growth , it is suggested that negative control of this 5 ' ( 3 ' ) -ribonucleotid... | NA | {
"id": "C0035548",
"name": "ribonucleotide",
"pos": [
307,
321
]
} | {
"id": "C0028630",
"name": "nucleotide",
"pos": [
431,
441
]
} |
prostaglandin e ( 1 ) gives only activation of the cyclase , while prostaglandin a ( 1 ) gives only inhibition of the activated cyclase . | NA | {
"id": "C0033559",
"name": "prostaglandin e",
"pos": [
0,
15
]
} | {
"id": "C0033554",
"name": "prostaglandin",
"pos": [
67,
80
]
} |
the inhibition by 7-oxa-13-prostynoic acid and by prostaglandin a ( 1 ) overrides enzyme activation produced by either escherichia coli enterotoxin , prostaglandin e ( 1 ) , or sodium fluoride , suggesting that in intestinal adenylate cyclase this site is the primary regulatory site ( i.e. , primary allosteric effector... | NA | {
"id": "C0033554",
"name": "prostaglandin",
"pos": [
50,
63
]
} | {
"id": "C0033559",
"name": "prostaglandin e",
"pos": [
150,
165
]
} |
this in vitro protein synthesizing system offers a model for studying possible translational control mechanisms regulating the synthesis of proteins involved in nerve cell function . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
14,
21
]
} | {
"id": "C0034861",
"name": "synthesis",
"pos": [
127,
136
]
} |
in the dividing myoblast there is a high level of messenger rna synthesis , including a 26s rna , the size of a putative messenger for the large subunit of myosin . | NA | {
"id": "C0035696",
"name": "messenger rna",
"pos": [
50,
63
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
92,
95
]
} |
these mononucleated cells histologically and biochemically are indistinguishable from authentic fibroblasts cultured under the same conditions : they synthesize ( alpha1 ) ( 2 ) alpha2 chains of collagen , large amounts of hyaluronic acid , and modest amounts of chondroitin sulfate . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
20,
25
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
96,
107
]
} |
these findings demonstrate that there is a population of single cells in 8-day muscle that is neither a myoblast nor a fibroblast , but is the common progenitor for cells in the myogenic and fibrogenic lineages : this progenitor , however , is beyond the point of readily yielding chondrogenic cells . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
119,
129
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
294,
299
]
} |
phosphate , arsenate , acetate , butyrate , beta-hydroxybutyrate , lactate , and bicarbonate + co ( 2 ) supported ca ( 2+ ) uptake , whereas the permeant anions , nitrate , thiocyanate , chlorate , and perchlorate , did not . | NA | {
"id": "C0031603",
"name": "phosphate",
"pos": [
0,
9
]
} | {
"id": "C0003075",
"name": "anions",
"pos": [
154,
160
]
} |
phosphate , arsenate , acetate , butyrate , beta-hydroxybutyrate , lactate , and bicarbonate + co ( 2 ) supported ca ( 2+ ) uptake , whereas the permeant anions , nitrate , thiocyanate , chlorate , and perchlorate , did not . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
154,
160
]
} | {
"id": "C0028125",
"name": "nitrate",
"pos": [
163,
170
]
} |
phosphate , arsenate , acetate , butyrate , beta-hydroxybutyrate , lactate , and bicarbonate + co ( 2 ) supported ca ( 2+ ) uptake , whereas the permeant anions , nitrate , thiocyanate , chlorate , and perchlorate , did not . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
154,
160
]
} | {
"id": "C0008173",
"name": "chlorate",
"pos": [
205,
213
]
} |
phosphate and the other active permeant anions move into the matrix in response to the alkaline-inside electrochemical gradient of protons generated across the mitochondrial membrane by electron transport , thus forming a negative-inside anion gradient . | NA | {
"id": "C0031603",
"name": "phosphate",
"pos": [
0,
9
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
238,
243
]
} |
since mitochondria in the cell are normally exposed to an excess of phosphate ( and the bicarbonate-co ( 2 ) system ) , particularly in state 4 , inward transport of these proton-yielding anions probably precedes and is necessary for inward transport of ca ( 2+ ) and other cations under biological conditions . | NA | {
"id": "C0031603",
"name": "phosphate",
"pos": [
68,
77
]
} | {
"id": "C0003075",
"name": "anions",
"pos": [
188,
194
]
} |
antibodies to listeria and staphylococcus were produced in both immunoglobulin m ( igm ) and immunoglobulin g ( igg ) classes in response to inoculation with the specific antigen . | NA | {
"id": "C0020861",
"name": "immunoglobulin m",
"pos": [
64,
80
]
} | {
"id": "C0021017",
"name": "immunoglobulin",
"pos": [
93,
107
]
} |
in the sera studied , igm was the predominant antibody produced to listeria , whereas cross-reactions with staphylococcus were observed in both the igm and the igg antibody classes . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
46,
54
]
} | {
"id": "C0021017",
"name": "igg",
"pos": [
160,
163
]
} |
in the sera studied , igm was the predominant antibody produced to listeria , whereas cross-reactions with staphylococcus were observed in both the igm and the igg antibody classes . | NA | {
"id": "C0020861",
"name": "igm",
"pos": [
22,
25
]
} | {
"id": "C0021017",
"name": "igg",
"pos": [
160,
163
]
} |
frank lead poisoning was found in some inhabitants of houses in the scottish highlands , exposed to soft water and lead-lined drinking water tanks . | NA | {
"id": "C0043047",
"name": "water",
"pos": [
105,
110
]
} | {
"id": "C0599638",
"name": "drinking water",
"pos": [
126,
140
]
} |
analysis of the individual population groups showed this correlation of pb-rbc with 2,3-dpg to be primarily related to the intercorrelation of each parameter with hemoglobin.rbc membrane na/k atpase , as per cent of total membrane atpase , had a median value of 60 % in 48 subjects . | NA | {
"id": "C0001479",
"name": "na/k atpase",
"pos": [
187,
198
]
} | {
"id": "C0001473",
"name": "atpase",
"pos": [
231,
237
]
} |
effects of chronic methadone treatment on bile flow and on metabolism and excretion of 3h-methadone . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
59,
69
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
74,
83
]
} |
gas-liquid chromatographic determination of methanol , ethanol , and isopropanol in cosmetics , using the headspace analytical technique . | NA | {
"id": "C0001963",
"name": "methanol",
"pos": [
44,
52
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
55,
62
]
} |
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