text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
gas-liquid chromatographic determination of methanol , ethanol , and isopropanol in cosmetics , using the headspace analytical technique . | NA | {
"id": "C0001962",
"name": "ethanol",
"pos": [
45,
52
]
} | {
"id": "C0022237",
"name": "isopropanol",
"pos": [
69,
80
]
} |
effect of magnesium adenosine 5'-triphosphate on the accessibility of the iron of clostridial azoferredoxin , a component of nitrogenase . | NA | {
"id": "C0085544",
"name": "azoferredoxin",
"pos": [
94,
107
]
} | {
"id": "C0028174",
"name": "nitrogenase",
"pos": [
125,
136
]
} |
malignant and benign neoplasms of the thyroid in patients treated for hyperthyroidism : a report of the cooperative thyrotoxicosis therapy follow-up study . | NA | {
"id": "C0020550",
"name": "hyperthyroidism",
"pos": [
70,
85
]
} | {
"id": "C0040156",
"name": "thyrotoxicosis",
"pos": [
116,
130
]
} |
the present data tend to suggest that ribonucleotide sequences are present in hsv dna , that they are covalently attached to the viral dna , and that they can form double-stranded structures . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
82,
85
]
} | {
"id": "C0012939",
"name": "viral dna",
"pos": [
129,
138
]
} |
the results support the model that both kirsten and harvey sarcoma viruses arose through a process of recombination or reassortment between mouse type-c viruses and sequences in rat cells and suggest that the information for transformation of fibroblasts may be contained in the rat type-c or cellular genome . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
243,
254
]
} | {
"id": "C0007634",
"name": "cellular",
"pos": [
293,
301
]
} |
the cleavage reactions of the head proteins p22 , p23 , p24 , and ipiii are prevented by l-canavanine as shown by the accumulation of the precursor proteins and the failure of the cleaved products to appear . l-canavanine also prevents the appearance of p12 ( tailplate protein ) and p20 ( head protein ) indicating that... | NA | {
"id": "C0033665",
"name": "precursor proteins",
"pos": [
138,
156
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
327,
335
]
} |
the fatty acids in cardiolipin , choline phosphoglyceride , ethanolamine phosphoglyceride , inositol phosphoglyceride , and serine phosphoglyceride in the human gastrocnemius muscle were studied for changes between early fetal age to middle age . | NA | {
"id": "C1959616",
"name": "choline phosphoglyceride",
"pos": [
33,
57
]
} | {
"id": "C0162448",
"name": "phosphoglyceride",
"pos": [
131,
147
]
} |
the fatty acids in cardiolipin , choline phosphoglyceride , ethanolamine phosphoglyceride , inositol phosphoglyceride , and serine phosphoglyceride in the human gastrocnemius muscle were studied for changes between early fetal age to middle age . | NA | {
"id": "C0031618",
"name": "ethanolamine",
"pos": [
60,
72
]
} | {
"id": "C0162448",
"name": "phosphoglyceride",
"pos": [
131,
147
]
} |
an increase in the concentration of fatty acids of the linolenic acid series was found in ethanolamine phosphoglyceride and serine phosphoglyceride , while only minor amounts of these fatty acids were present in choline phosphoglyceride and inositol phosphoglyceride and not at all in cardiolipin . | NA | {
"id": "C0031618",
"name": "ethanolamine phosphoglyceride",
"pos": [
90,
119
]
} | {
"id": "C0162448",
"name": "phosphoglyceride",
"pos": [
250,
266
]
} |
an increase in the concentration of fatty acids of the linolenic acid series was found in ethanolamine phosphoglyceride and serine phosphoglyceride , while only minor amounts of these fatty acids were present in choline phosphoglyceride and inositol phosphoglyceride and not at all in cardiolipin . | NA | {
"id": "C1959616",
"name": "choline phosphoglyceride",
"pos": [
212,
236
]
} | {
"id": "C0162448",
"name": "phosphoglyceride",
"pos": [
250,
266
]
} |
hemorrhagic shock was produced in dogs by bleeding to a systemic blood pressure of 45 mm hg for 3 hours , followed by reinfusion of the shed blood . | NA | {
"id": "C0036982",
"name": "hemorrhagic shock",
"pos": [
0,
17
]
} | {
"id": "C0019080",
"name": "bleeding",
"pos": [
42,
50
]
} |
these data are consistent with the earlier findings that indicate mdf to be a peptide having a molecular weight of 500-1,000 . | NA | {
"id": "C0027047",
"name": "mdf",
"pos": [
66,
69
]
} | {
"id": "C0030956",
"name": "peptide",
"pos": [
78,
85
]
} |
these and other observations suggest that the isoprinosine stimulation of host ribonucleic acid metabolism may be coupled to the production of ribosomes that do not effectively translate exogenous messenger ribonucleic acid . | NA | {
"id": "C0035668",
"name": "ribonucleic acid",
"pos": [
79,
95
]
} | {
"id": "C0035696",
"name": "messenger ribonucleic acid",
"pos": [
197,
223
]
} |
the drug was bactericidal when the amino acids methionine and glycine , plus a purine or purine nucleoside , were also present . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
35,
46
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
62,
69
]
} |
seventy-four strains of streptococcus bovis and 35 strains of enterococci ( streptococcus faecalis and its varieties , streptococcus faecium and streptococcus durans ) , most of which were isolated from patients with endocarditis , were tested for their susceptibility to penicillin , ampicillin , erythromycin , cephalo... | NA | {
"id": "C0030842",
"name": "penicillin",
"pos": [
272,
282
]
} | {
"id": "C0025643",
"name": "methicillin",
"pos": [
340,
351
]
} |
under double-blind protocol , a controlled comparison was made between a new cephalosporin , cephacetrile , and cephalothin or cephaloridine . | NA | {
"id": "C3536856",
"name": "cephalosporin",
"pos": [
77,
90
]
} | {
"id": "C0007714",
"name": "cephacetrile",
"pos": [
93,
105
]
} |
under double-blind protocol , a controlled comparison was made between a new cephalosporin , cephacetrile , and cephalothin or cephaloridine . | NA | {
"id": "C3536856",
"name": "cephalosporin",
"pos": [
77,
90
]
} | {
"id": "C0007727",
"name": "cephaloridine",
"pos": [
127,
140
]
} |
under double-blind protocol , a controlled comparison was made between a new cephalosporin , cephacetrile , and cephalothin or cephaloridine . | NA | {
"id": "C0007714",
"name": "cephacetrile",
"pos": [
93,
105
]
} | {
"id": "C0007735",
"name": "cephalothin",
"pos": [
112,
123
]
} |
infecting strains of staphylococci and proteus mirabilis had a lower median inhibitory concentration for cephalothin than cephacetrile ; | NA | {
"id": "C0007735",
"name": "cephalothin",
"pos": [
105,
116
]
} | {
"id": "C0007714",
"name": "cephacetrile",
"pos": [
122,
134
]
} |
the average peak serum level 1 h after a dose of 2 g intravenously was 74.9 +/- 21 and 21.5 +/- 8.7 mug/ml for cephacetrile and cephalothin , respectively ; | NA | {
"id": "C0007714",
"name": "cephacetrile",
"pos": [
111,
123
]
} | {
"id": "C0007735",
"name": "cephalothin",
"pos": [
128,
139
]
} |
in the urine , the concentration of cephacetrile was three times higher than that of cephalothin . | NA | {
"id": "C0007714",
"name": "cephacetrile",
"pos": [
36,
48
]
} | {
"id": "C0007735",
"name": "cephalothin",
"pos": [
85,
96
]
} |
intravenous use of cephacetrile was discontinued prematurely more often than was use of cephalothin , suggesting less tolerance . | NA | {
"id": "C0007714",
"name": "cephacetrile",
"pos": [
19,
31
]
} | {
"id": "C0007735",
"name": "cephalothin",
"pos": [
88,
99
]
} |
from this limited but controlled experience , cephacetrile can be considered comparable to cephalothin in antimicrobial treatment and overall side reactions . | NA | {
"id": "C0007714",
"name": "cephacetrile",
"pos": [
46,
58
]
} | {
"id": "C0007735",
"name": "cephalothin",
"pos": [
91,
102
]
} |
the gentamicin , carbenicillin , colistin , and polymyxin minimal inhibitory concentration of each strain was measured by the agar dilution method employing the steers inocula replicator . | NA | {
"id": "C0009316",
"name": "colistin",
"pos": [
33,
41
]
} | {
"id": "C0032539",
"name": "polymyxin",
"pos": [
48,
57
]
} |
tobramycin , a new aminoglycoside antimicrobial , was evaluated as therapy for infections due to gram-negative bacilli in 15 seriously ill patients with underlying diseases . | NA | {
"id": "C0002556",
"name": "aminoglycoside",
"pos": [
19,
33
]
} | {
"id": "C1136254",
"name": "antimicrobial",
"pos": [
34,
47
]
} |
the permeability sequence obtained by potential measurement is scn > no ( 3 ) > cl = br > i > clo ( 3 ) and the permeability ratio is independent of the mole fraction of anions.7 . | NA | {
"id": "C0021966",
"name": "i",
"pos": [
11,
12
]
} | {
"id": "C0003075",
"name": "anions",
"pos": [
170,
176
]
} |
it is suggested that the stimulation of phospholipid metabolism that occurs in several other tissues in the presence of adrenaline or noradrenaline may also involve alpha-receptors . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
120,
130
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
134,
147
]
} |
sodium hexan-1-yl sulphate and certain related alkyl sulphate esters have been shown to serve as inducers of the formation of primary alkylsulphatases ( designated as p1 and p2 ) in pseudomonas c12b . | NA | {
"id": "C0074769",
"name": "sodium",
"pos": [
0,
6
]
} | {
"id": "C0038720",
"name": "sulphate",
"pos": [
53,
61
]
} |
cell extracts contain this anion as the major ( 35 ) s-labelled metabolite although two unidentified labelled metabolites as well as choline o- [ ( 35 ) s ] sulphate occur in trace quantities in some extracts . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
27,
32
]
} | {
"id": "C0038720",
"name": "sulphate",
"pos": [
157,
165
]
} |
mouse livers were perfused in situ through the portal vein with the disaccharides sucrose , lactose , maltose , and cellobiose in hypertonic concentrations ( 0.5 m ) . | NA | {
"id": "C0012611",
"name": "disaccharides",
"pos": [
68,
81
]
} | {
"id": "C0038636",
"name": "sucrose",
"pos": [
82,
89
]
} |
mouse livers were perfused in situ through the portal vein with the disaccharides sucrose , lactose , maltose , and cellobiose in hypertonic concentrations ( 0.5 m ) . | NA | {
"id": "C0012611",
"name": "disaccharides",
"pos": [
68,
81
]
} | {
"id": "C0024658",
"name": "maltose",
"pos": [
102,
109
]
} |
however , a partial nucleic acid homology was found between woolly monkey and gibbon ape type c viral [ ( 3 ) h ] dna and normal mouse cellular dna . | NA | {
"id": "C0028606",
"name": "nucleic acid",
"pos": [
20,
32
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
144,
147
]
} |
[ experimental and clinical studies on a protease from aspergillus oryzae ( brinase ) : fibrinogen turnover , thrombocyte aggregation and occlusion of the scribner shunt ] . | NA | {
"id": "C0030946",
"name": "protease",
"pos": [
41,
49
]
} | {
"id": "C0006188",
"name": "brinase",
"pos": [
76,
83
]
} |
numerical coding for types of seizure based on the clinical and electroencephalographical classification of epileptic seizures . | NA | {
"id": "C0036572",
"name": "seizure",
"pos": [
30,
37
]
} | {
"id": "C0014544",
"name": "epileptic seizures",
"pos": [
108,
126
]
} |
three cases are reported of concurrence of malignant gliomas ( astrocytomas and glioblastomas ) with multiple sclerosis ( ms ) . | NA | {
"id": "C0004114",
"name": "astrocytomas",
"pos": [
63,
75
]
} | {
"id": "C0017636",
"name": "glioblastomas",
"pos": [
80,
93
]
} |
the insulin dependent group had either no glucose decrease or a rise in blood glucose following intravenous administration of tolbutamide . | NA | {
"id": "C0017725",
"name": "glucose",
"pos": [
42,
49
]
} | {
"id": "C0005802",
"name": "in blood glucose",
"pos": [
69,
85
]
} |
although meningococci are susceptible to the tetracyclines by testing in vitro , oxytetracycline ( oc ) and doxycycline ( dc ) have failed to eliminate carriage , whereas minocycline ( mc ) has been effective . | NA | {
"id": "C0039651",
"name": "tetracyclines",
"pos": [
45,
58
]
} | {
"id": "C0030092",
"name": "oxytetracycline",
"pos": [
81,
96
]
} |
although meningococci are susceptible to the tetracyclines by testing in vitro , oxytetracycline ( oc ) and doxycycline ( dc ) have failed to eliminate carriage , whereas minocycline ( mc ) has been effective . | NA | {
"id": "C0039651",
"name": "tetracyclines",
"pos": [
45,
58
]
} | {
"id": "C0013090",
"name": "doxycycline",
"pos": [
108,
119
]
} |
although meningococci are susceptible to the tetracyclines by testing in vitro , oxytetracycline ( oc ) and doxycycline ( dc ) have failed to eliminate carriage , whereas minocycline ( mc ) has been effective . | NA | {
"id": "C0039651",
"name": "tetracyclines",
"pos": [
45,
58
]
} | {
"id": "C0026187",
"name": "minocycline",
"pos": [
171,
182
]
} |
cefoxitin , 3-carbamoyloxymethyl-7-alpha-methoxy-7- [ 2- ( 2-thienyl ) acetamido ] -3-cephem-4- carboxylic acid , a semisynthetic cephamycin antibiotic shown to have broad-spectrum activity in vitro , is active also in vivo against a wide variety of bacteria including penicillin-resistant staphylococci . | NA | {
"id": "C0007557",
"name": "cefoxitin",
"pos": [
0,
9
]
} | {
"id": "C0007736",
"name": "cephamycin",
"pos": [
130,
140
]
} |
seventy-five isolates of neisseria gonorrhoeae recovered from patients in this study were all inhibited by 1.0 mug or less of ampicillin or amoxicillin per ml ; | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
126,
136
]
} | {
"id": "C0002645",
"name": "amoxicillin",
"pos": [
140,
151
]
} |
after 2.0 g of ampicillin was given with probenecid , the serum levels during the 5- to 12-h period approached those achieved with 3.5 g of ampicillin plus probenecid , and actually exceeded levels attained during the same interval with 3.0 g of amoxicillin administered alone . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
15,
25
]
} | {
"id": "C0002645",
"name": "amoxicillin",
"pos": [
246,
257
]
} |
serum and milk concentrations of rifamycin sv and rifampin were determined in lactating ewes after a single intravenous injection , and pharmacokinetic parameters were evaluated by the two-compartment open-system model . | NA | {
"id": "C0035609",
"name": "rifamycin sv",
"pos": [
33,
45
]
} | {
"id": "C0035608",
"name": "rifampin",
"pos": [
50,
58
]
} |
rifampin was distributed throughout a greater volume than rifamycin sv and was eliminated more slowly from the body . | NA | {
"id": "C0035608",
"name": "rifampin",
"pos": [
0,
8
]
} | {
"id": "C0035609",
"name": "rifamycin sv",
"pos": [
58,
70
]
} |
the concentrations of the two drugs , both lipophilic weak acids , in milk after intravenous or intramuscular injection were lower than in serum , but rifampin was detected in milk sooner and for longer periods than rifamycin sv . | NA | {
"id": "C0035608",
"name": "rifampin",
"pos": [
151,
159
]
} | {
"id": "C0035609",
"name": "rifamycin sv",
"pos": [
216,
228
]
} |
under constant serum drug concentrations , the observed milk/serum ultrafiltrate concentrations ratios ( 0.19 to 0.29 for rifamycin sv , and 0.90 to 1.28 for rifampin ) were close to the calculated ratios derived from the ph-pk passive diffusion concept . | NA | {
"id": "C0035609",
"name": "rifamycin sv",
"pos": [
122,
134
]
} | {
"id": "C0035608",
"name": "rifampin",
"pos": [
158,
166
]
} |
forty-one strains of streptococcus mutans ( 34 from blood specimens from patients with endocarditis and 7 from stock cultures ) were tested for susceptibility to penicillin , ampicillin , methicillin , erythromycin , cephalothin , vancomycin , chloramphenicol , tetracycline , gentamicin , streptomycin , and kanamycin . | NA | {
"id": "C0030842",
"name": "penicillin",
"pos": [
162,
172
]
} | {
"id": "C0025643",
"name": "methicillin",
"pos": [
188,
199
]
} |
furthermore , e. coli and klebsiella strains which are susceptible to the cephalosporins are generally more susceptible to the cephamycin analog . | NA | {
"id": "C3536856",
"name": "cephalosporins",
"pos": [
74,
88
]
} | {
"id": "C0007736",
"name": "cephamycin",
"pos": [
127,
137
]
} |
sera from 92 patients with adult coeliac disease , 20 patients with crohn 's disease , and 89 control patients were tested for the presence and immunoglobulin class of anticonnective tissue antibodies . | NA | {
"id": "C0021017",
"name": "immunoglobulin",
"pos": [
144,
158
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
190,
200
]
} |
recombined t and b cells of the siblings were stimulated with allogeneic cells , and karyotype analysis of proliferating cells performed . | NA | {
"id": "C3485979",
"name": "allogeneic cells",
"pos": [
62,
78
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
121,
126
]
} |
balb/3t3 cells transformed by the kirsten sarcoma virus ( nonvirus producer balb/3t3 cells ) and mutant cell lines derived therefrom by treatment with bromodeoxyuridine ( brdu ) were analyzed for expression of virus-specific rna using single-stranded dna transcripts of rauscher leukemia virus ( rlv ) , a virus activate... | NA | {
"id": "C0012935",
"name": "single-stranded dna",
"pos": [
235,
254
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
378,
381
]
} |
a new procedure for synthesis of 3-keto derivatives of sphingolipids and its application for study of fatty acid composition of brain ceramides and cerebrosides containing dihydrosphingosine of sphingosine . | NA | {
"id": "C0007745",
"name": "ceramides",
"pos": [
134,
143
]
} | {
"id": "C0007805",
"name": "cerebrosides",
"pos": [
148,
160
]
} |
a neurohypophyseal hormone analog with selective oxytocin-like activities and resistance to enzymatic inactivation : an approach to the design of peptide drugs . | NA | {
"id": "C0032017",
"name": "neurohypophyseal hormone",
"pos": [
2,
26
]
} | {
"id": "C0030095",
"name": "oxytocin",
"pos": [
49,
57
]
} |
an improved procedure was used to conjugate ferritin to antibodies specific for the nh ( 2 ) -terminal extensions on the precursor form of collagen known as procollagen . | NA | {
"id": "C0009325",
"name": "collagen",
"pos": [
139,
147
]
} | {
"id": "C0033235",
"name": "procollagen",
"pos": [
157,
168
]
} |
ten hybrid cell clones derived from the fusion of fu5 cells and mouse fibroblasts , as well as 14 hepatoma subclones of fu5 cells , all produce albumin but at different rates , ranging from about 0.09 to 36.7 mug/mg of protein per 72 hr . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
144,
151
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
219,
226
]
} |
the action of restriction enzymes on polyoma dna was studied with uniformly ( 32 ) p-labeled viral dna obtained from either infected 3t6 or secondary mouse-embryo cells . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
45,
48
]
} | {
"id": "C0012939",
"name": "viral dna",
"pos": [
93,
102
]
} |
[ oral medication of iron : tolerance for iron sulphate and iron sulphate plus succinic acid , influence on haemoglobin concentration of healthy subjects ( author 's transl ) ] . | NA | {
"id": "C0302583",
"name": "iron",
"pos": [
21,
25
]
} | {
"id": "C0060282",
"name": "iron sulphate",
"pos": [
60,
73
]
} |
there were 67 adenocarcinomas , 7 squamous cell carcinomas and one each of villous adenoma and carcinoid . | NA | {
"id": "C0001418",
"name": "adenocarcinomas",
"pos": [
14,
29
]
} | {
"id": "C0007095",
"name": "carcinoid",
"pos": [
95,
104
]
} |
their susceptibility to bb-k8 ( amikacin ) , a new broad-spectrum semisynthetic derivative of kanamycin a , and to the other agents , was determined on mueller-hinton medium by the twofold agar dilution method . | NA | {
"id": "C0002499",
"name": "amikacin",
"pos": [
32,
40
]
} | {
"id": "C0022487",
"name": "kanamycin",
"pos": [
94,
103
]
} |
test results revealed that 60.5 % of the isolates were resistant to 8 mug of tobramycin per ml , 67.1 % to 8 mug of gentamicin per ml , 86.2 % to 20 mug of kanamycin a per ml , and only 8.6 % to 20 mug of amikacin per ml . | NA | {
"id": "C0022487",
"name": "kanamycin",
"pos": [
156,
165
]
} | {
"id": "C0002499",
"name": "amikacin",
"pos": [
205,
213
]
} |
the three major proteins of vesicular stomatitis virus-indiana , glycoprotein ( g ) , nucleoprotein ( n ) , and membrane protein ( m ) , were isolated and characterized by means of specific monocomponent antisera . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
16,
24
]
} | {
"id": "C0028612",
"name": "nucleoprotein",
"pos": [
86,
99
]
} |
the three major proteins of vesicular stomatitis virus-indiana , glycoprotein ( g ) , nucleoprotein ( n ) , and membrane protein ( m ) , were isolated and characterized by means of specific monocomponent antisera . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
16,
24
]
} | {
"id": "C0025252",
"name": "membrane protein",
"pos": [
112,
128
]
} |
these results suggest that the effect of tdr on hsv-2 replication occurs at a stage of dna synthesis other than reduction of cytidine nucleotides to deoxycytidine nucleotides . | NA | {
"id": "C0010715",
"name": "cytidine",
"pos": [
125,
133
]
} | {
"id": "C0011485",
"name": "deoxycytidine",
"pos": [
149,
162
]
} |
( 3 ) h-labeled 35s rna from purified avian myeloblastosis virus ( amv ) was exhaustively hybridized with an excess of normal chicken dna to remove all viral rna sequences which are complementary to dna from uninfected cells . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
20,
23
]
} | {
"id": "C0035736",
"name": "viral",
"pos": [
152,
157
]
} |
since the side chain of homoserine is similar in size to that of aspartic acid , it is concluded that the loss of enzymatic activity is the direct result of the chemical modification of the carboxyl side chain of aspartic acid 52 , thus showing that this amino acid is essential for the catalytic action of the enzyme . | NA | {
"id": "C0019892",
"name": "homoserine",
"pos": [
24,
34
]
} | {
"id": "C0002520",
"name": "amino acid",
"pos": [
255,
265
]
} |
the anterior pituitary hormones , luteinizing hormone , follicle-stimulating hormone , adrenocorticotropic hormone , growth hormone , thyroid-stimulating hormone , and prolactin , were found to be substrates for this enzyme . | NA | {
"id": "C0032016",
"name": "anterior pituitary",
"pos": [
4,
22
]
} | {
"id": "C0037663",
"name": "growth hormone",
"pos": [
117,
131
]
} |
the anterior pituitary hormones , luteinizing hormone , follicle-stimulating hormone , adrenocorticotropic hormone , growth hormone , thyroid-stimulating hormone , and prolactin , were found to be substrates for this enzyme . | NA | {
"id": "C0032016",
"name": "anterior pituitary",
"pos": [
4,
22
]
} | {
"id": "C0040160",
"name": "thyroid-stimulating hormone",
"pos": [
134,
161
]
} |
previous studies have shown that arthrobacter pyridinolis can transport d-fructose or l-rhamnose using either a phosphoenolpyruvate : hexose phosphotransferase ( phosphoenolpyruvate : protein phosphotransferase , ec 2.7.3.9 ) system or a respiration-coupled transport system which requires the presence of exogenous l-ma... | NA | {
"id": "C0016745",
"name": "fructose",
"pos": [
74,
82
]
} | {
"id": "C0019494",
"name": "hexose",
"pos": [
134,
140
]
} |
the hist gene codes for an enzyme responsible for the conversion of uridine to pseudouridine ( psi ) in the anticodon region of many trna species in salmonella typhimurium . | NA | {
"id": "C0041984",
"name": "uridine",
"pos": [
68,
75
]
} | {
"id": "C0033846",
"name": "pseudouridine",
"pos": [
79,
92
]
} |
we show here that in hist mutants the regulation of the leucine and the isoleucine and valine operons is also affected : the enzymes of these operons are refractory to repression by the branched chain amino acids . | NA | {
"id": "C0023401",
"name": "leucine",
"pos": [
56,
63
]
} | {
"id": "C0002521",
"name": "branched chain amino acids",
"pos": [
186,
212
]
} |
we show here that in hist mutants the regulation of the leucine and the isoleucine and valine operons is also affected : the enzymes of these operons are refractory to repression by the branched chain amino acids . | NA | {
"id": "C0022192",
"name": "isoleucine",
"pos": [
72,
82
]
} | {
"id": "C0002521",
"name": "branched chain amino acids",
"pos": [
186,
212
]
} |
we show here that in hist mutants the regulation of the leucine and the isoleucine and valine operons is also affected : the enzymes of these operons are refractory to repression by the branched chain amino acids . | NA | {
"id": "C0042285",
"name": "valine",
"pos": [
87,
93
]
} | {
"id": "C0002521",
"name": "branched chain amino acids",
"pos": [
186,
212
]
} |
the alteration in the regulation of branched chain amino acid operons may also explain why hist mutants are resistant to inhibition of growth by the amino acid analogues 5,5,5-trifluoroleucine , beta-hydroxyleucine , and norleucine and by the oligopeptides glycylglycylnorleucine and norleucylnorleucine . | NA | {
"id": "C0002521",
"name": "branched chain",
"pos": [
36,
50
]
} | {
"id": "C0002520",
"name": "amino acid",
"pos": [
149,
159
]
} |
however , restoration of coq enzyme activity in muscle by oral administration of coq could lead to increased use of cpk in muscle to form phosphocreatine from creatine and atp , with a corresponding decrease in serum levels of cpk . | NA | {
"id": "C0031634",
"name": "phosphocreatine",
"pos": [
138,
153
]
} | {
"id": "C0010286",
"name": "creatine",
"pos": [
159,
167
]
} |
[ degradation of chlorinated benzenes , phenols and cyclohexane derivatives by benzene and phenol utilizing soil bacteria under aerobic conditions ( author 's transl ) ] . | NA | {
"id": "C0005037",
"name": "derivatives",
"pos": [
64,
75
]
} | {
"id": "C0031428",
"name": "phenol",
"pos": [
91,
97
]
} |
[ effect of dopa and metopirone on the monamine oxidase activity and catecholamine and ascorbic acid content in guinea pig tissues ] . | NA | {
"id": "C0013023",
"name": "dopa",
"pos": [
12,
16
]
} | {
"id": "C0007412",
"name": "catecholamine",
"pos": [
69,
82
]
} |
nuclear proteins during development : incorporation of leucine into histones of rainbow trout during early development . | NA | {
"id": "C0028589",
"name": "nuclear proteins",
"pos": [
0,
16
]
} | {
"id": "C0019652",
"name": "histones",
"pos": [
68,
76
]
} |
a comparative study of muscle contraction and superprecipitation using trinitrophenylated myosin and active myosin subfragments . | NA | {
"id": "C0027096",
"name": "myosin",
"pos": [
90,
96
]
} | {
"id": "C0027117",
"name": "myosin subfragments",
"pos": [
108,
127
]
} |
in intestinal and leg lymph , labeled t4 appeared eight and four times as rapidly as albumin indicating that t4 crosses capillaries in these areas independently of and much more rapidly than albumin and other proteins having similar distribution kinetics . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
85,
92
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
209,
217
]
} |
the lymph : plasma ratios for all the t4-binding proteins including albumin were very similar in any one area showing that the relative fractional rates of transcapillary movement of these proteins were very similar . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
68,
75
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
189,
197
]
} |
the viral dna synthesized in d mutants under these conditions progresses in normal fashion through replicative intermediate molecules to mature component i and ii dna molecules . | NA | {
"id": "C0012939",
"name": "viral dna",
"pos": [
4,
13
]
} | {
"id": "C0012854",
"name": "dna molecules",
"pos": [
163,
176
]
} |
a new episomic element controlling fermentative metabolism and excretion of amino acids by citrobacter intermedium c3 . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
48,
58
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
63,
72
]
} |
consequently , the s factor is different from other extrachromosomal genetic factors whose elimination does not modify central metabolism . | NA | {
"id": "C0221102",
"name": "elimination",
"pos": [
91,
102
]
} | {
"id": "C0025519",
"name": "metabolism",
"pos": [
127,
137
]
} |
knowledge obtained in a previous investigation of the kinetics of phosphate incorporation into their precursors , adenosine 5'-triphosphate and guanosine 5'-triphosphate , allowed calculation of the average half-lives of these termini , which were found to be approximately 170 s at 21.5 c for both . | NA | {
"id": "C0022702",
"name": "kinetics",
"pos": [
54,
62
]
} | {
"id": "C0018517",
"name": "half-lives",
"pos": [
207,
217
]
} |
the protein of molecular weight 34,500 accounted for 66 % of the total protein of the l-membrane . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
4,
11
]
} | {
"id": "C0025252",
"name": "protein",
"pos": [
71,
78
]
} |
yeast extract enrichment of such a yeast phase consisting of 10 ( 4 ) yeasts per ml induces a quantitative conversion of the yeasts to true hyphae . | NA | {
"id": "C0873195",
"name": "yeast extract",
"pos": [
0,
13
]
} | {
"id": "C0043393",
"name": "yeasts",
"pos": [
125,
131
]
} |
mortality has continued to decrease and there has been only one death in the last 87 consecutive transplants , including 57 consecutive cadaver transplants . | NA | {
"id": "C0011065",
"name": "death",
"pos": [
64,
69
]
} | {
"id": "C0006629",
"name": "cadaver",
"pos": [
136,
143
]
} |
to study the role of wound dehydration in determining burn depth , 5 % body surface area , 75 c , 10 second burns ( in which the zone of stasis included the full thickness of skin ) were inflicted on the backs of guinea pigs and subsequent mechanical trauma was prevented . | NA | {
"id": "C0006434",
"name": "burns",
"pos": [
108,
113
]
} | {
"id": "C0043251",
"name": "trauma",
"pos": [
251,
257
]
} |
antisera raised in rabbits against protein subunits of rat liver ferritin contain antibodies ( igg ) that precipitate subunits and other antibodies ( igg ) that precipitate undissociated ferritin and apoferritin . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
0,
8
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
137,
147
]
} |
the synthesis of keratin proteins during development of the embryonic chick feather was studied by quantitative gel electrophoresis of the reduced and carboxymethylated proteins . | NA | {
"id": "C0034861",
"name": "synthesis",
"pos": [
4,
13
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
169,
177
]
} |
ribosomal rnas ( 28 + 18s and 5s ) and 4s rna extracted from the chironomid glyptotendipes barbipes were iodinated in vitro with ( 125 ) i and hybridized to the salivary gland chromosomes of g. barbipes and drosophila melanogaster . | NA | {
"id": "C0035701",
"name": "ribosomal rnas",
"pos": [
0,
14
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
42,
45
]
} |
several creatine analogs are as effective as creatine in stimulating muscle protein synthesis , creatinine and amino acids such as arginine and glycine are not . | NA | {
"id": "C0010286",
"name": "creatine",
"pos": [
8,
16
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
111,
122
]
} |
several creatine analogs are as effective as creatine in stimulating muscle protein synthesis , creatinine and amino acids such as arginine and glycine are not . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
111,
122
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
144,
151
]
} |
an immunochemical study of the calcium ion-binding protein ( troponin-c ) and the inhibitory protein ( troponin-i ) of the troponin complex and their interaction . | NA | {
"id": "C0077401",
"name": "troponin-i",
"pos": [
103,
113
]
} | {
"id": "C0041199",
"name": "troponin complex",
"pos": [
123,
139
]
} |
conformation of nucleosides : circular dichroism study of solvent effect on the syn-anti conformational equilibrium of pyrimidine nucleosides . | NA | {
"id": "C0028621",
"name": "nucleosides",
"pos": [
16,
27
]
} | {
"id": "C0034287",
"name": "pyrimidine nucleosides",
"pos": [
119,
141
]
} |
the endo-beta- ( 1 -- > 3 ) -glucanase was further purified by diethylaminoethyl-cellulose and hydroxyapatite chromatography , whereas the endo-beta- ( 1 -- > 6 ) -glucanase could be purified further by diethylamino-ethyl-cellulose and carboxymethyl cellulose chromatography . | NA | {
"id": "C0007648",
"name": "cellulose",
"pos": [
81,
90
]
} | {
"id": "C0059756",
"name": "ethyl-cellulose",
"pos": [
216,
231
]
} |
common oxidant lesion of mitochondrial redox state produced by nitrogen dioxide , ozone , and high oxygen in alveolar macrophages . | NA | {
"id": "C0030106",
"name": "ozone",
"pos": [
82,
87
]
} | {
"id": "C0030054",
"name": "oxygen",
"pos": [
99,
105
]
} |
amoxicillin : in vitro susceptibility of `` '' blood culture strains '' '' of gram-negative bacilli and comparisons with penicillin g ampicillin , and carbenicillin . | NA | {
"id": "C0002645",
"name": "amoxicillin",
"pos": [
0,
11
]
} | {
"id": "C0002680",
"name": "g ampicill",
"pos": [
132,
142
]
} |
amoxicillin : in vitro susceptibility of `` '' blood culture strains '' '' of gram-negative bacilli and comparisons with penicillin g ampicillin , and carbenicillin . | NA | {
"id": "C0030827",
"name": "h penicillin",
"pos": [
119,
131
]
} | {
"id": "C0002680",
"name": "g ampicill",
"pos": [
132,
142
]
} |
amoxicillin less effective than ampicillin against shigella in vitro and in vivo : relationship of efficacy to activity in serum . | NA | {
"id": "C0002645",
"name": "amoxicillin",
"pos": [
0,
11
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
32,
42
]
} |
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