text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
one group was receiving long-term corticotrophin treatment , the second was undergoing long-term corticosteroid treatment , and the third had never received systemic hormone therapy . | NA | {
"id": "C0001617",
"name": "corticosteroid",
"pos": [
97,
111
]
} | {
"id": "C0019932",
"name": "hormone",
"pos": [
166,
173
]
} |
the rise was transient in cases of hepatitis and a transient rise was also seen after alcohol intake ceased in two patients with cirrhosis . alpha-fetoprotein levels exceeding 500 ng/ml were 30-50 times more common in primary liver cancer than in other liver diseases . | NA | {
"id": "C0019158",
"name": "hepatitis",
"pos": [
35,
44
]
} | {
"id": "C0023895",
"name": "liver diseases",
"pos": [
253,
267
]
} |
the rise was transient in cases of hepatitis and a transient rise was also seen after alcohol intake ceased in two patients with cirrhosis . alpha-fetoprotein levels exceeding 500 ng/ml were 30-50 times more common in primary liver cancer than in other liver diseases . | NA | {
"id": "C0023890",
"name": "cirrhosis",
"pos": [
129,
138
]
} | {
"id": "C0023895",
"name": "liver diseases",
"pos": [
253,
267
]
} |
quantitative cytochemical estimation of the effect of pentagastrin ( 0.005-5 pg-ml ) and of plasma gastrin on the guinea-pig fundus in vitro . | NA | {
"id": "C0030859",
"name": "pentagastrin",
"pos": [
54,
66
]
} | {
"id": "C0017151",
"name": "gastrin",
"pos": [
99,
106
]
} |
single-dose oral therapy for uncomplicated gonorrhea : comparison of amoxicillin and ampicillin given with and without probenecid . | NA | {
"id": "C0002645",
"name": "amoxicillin",
"pos": [
69,
80
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
85,
95
]
} |
clinical evaluation of a rapid screening test for sickle cell trait ( s- ) and sickle cell anemia ( ss ) . | NA | {
"id": "C0037054",
"name": "sickle cell trait",
"pos": [
50,
67
]
} | {
"id": "C0002895",
"name": "sickle cell anemia",
"pos": [
79,
97
]
} |
evidence of homology between the beta-chain of human haptoglobin and the chymotrypsin family of serine proteases . | NA | {
"id": "C0008742",
"name": "chymotrypsin",
"pos": [
73,
85
]
} | {
"id": "C0036734",
"name": "serine proteases",
"pos": [
96,
112
]
} |
we interpret this to indicate that there exists within the sodium channel a specific metal cation site which is responsible for the co-ordination of the ions during their passage through the membrane . | NA | {
"id": "C0007447",
"name": "cation",
"pos": [
91,
97
]
} | {
"id": "C0022023",
"name": "ions",
"pos": [
153,
157
]
} |
assay of testosterone , progesterone and 17alpha-hydroxyprogesterone in human plasma by radioimmunoassay after separation on hydroxyalkoxypropyl sephadex . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
24,
36
]
} | {
"id": "C0020387",
"name": "17alpha-hydroxyprogesterone",
"pos": [
41,
68
]
} |
enhanced susceptibility of penicillin-resistant staphylococci to phagocytosis after in vitro incubation with low doses of nafcillin . | NA | {
"id": "C0030842",
"name": "penicillin",
"pos": [
27,
37
]
} | {
"id": "C0027324",
"name": "nafcillin",
"pos": [
122,
131
]
} |
it is concluded first that albumin is not secreted by the chief and parietal cells of the mucosa and probably passes through the gastric wall between the cells of the mucosa , perhaps during the exfoliation of the surface epithelial cells , and secondly that the stomach is one of the sites of serum albumin breakdown , ... | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
27,
34
]
} | {
"id": "C0036773",
"name": "serum albumin",
"pos": [
422,
435
]
} |
effect of actinomycin d , cycloheximide and puromycin on hepatic adenosine 3',5'-monophosphate in rats treated with glucagon . | NA | {
"id": "C0034145",
"name": "puromycin",
"pos": [
44,
53
]
} | {
"id": "C0001443",
"name": "adenosine",
"pos": [
65,
74
]
} |
of the components that failed to appear , or are reduced in amount , on the gels ( protein bands ia , ib , iva , and vii ) , two are known to be the subunits of spectrin ( bands ia and ib ) , an inner-surface peripheral protein . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
83,
90
]
} | {
"id": "C0025252",
"name": "surface",
"pos": [
201,
208
]
} |
the identifiable dna-binding proteins are the products of genes 43 , riia , 46 , 30 , 39 , 52 , betagt , 32 , and internal protein iii . | NA | {
"id": "C0012940",
"name": "dna-binding proteins",
"pos": [
17,
37
]
} | {
"id": "C0033684",
"name": "products",
"pos": [
46,
54
]
} |
reactivity of the antiserum with hodgkin 's disease target cells could be removed by absorption of the antibody with additional antigen of density 1.15-1.21 obtained from other hodgkin 's disease cultures . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
18,
27
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
103,
111
]
} |
1alpha,25-dihydroxyvitamin d ( 3 ) was examined for its ability to affect the dna-dependent rna polymerases ( nucleosidetriphosphate : rna nucleotidyltransferase , ec 2.7.7.6 ) of rachitic chick intestinal cell nuclei in vivo . | NA | {
"id": "C0035681",
"name": "dna-dependent rna polymerases",
"pos": [
78,
107
]
} | {
"id": "C0035673",
"name": "rna",
"pos": [
135,
138
]
} |
when a noncovalent complex of the enzyme and this cardiac glycoside derivative was photolyzed , a covalent bond was formed between the ligand and the larger of the two polypeptide subunits of the enzyme . | NA | {
"id": "C0026741",
"name": "complex",
"pos": [
19,
26
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
196,
202
]
} |
the homogeneous poly ( a ) segments isolated from rnase t1 digests of 60-70s [ ( 32 ) p ] rna consist of one cytidylate , one uridylate , and about 190 adenylate residues , while those isolated from rnase a digests consist exclusively of adenylate residues . | NA | {
"id": "C0018364",
"name": "rnase t1",
"pos": [
50,
58
]
} | {
"id": "C0014241",
"name": "rnase",
"pos": [
199,
204
]
} |
a dna-histone f1 complex , which consisted of dna and all of the histone f1 and completely lacked other histones , was obtained by sedimenting nucleohistone through 0.05 % sodium dodecylsulfate . | NA | {
"id": "C0000702",
"name": "a dna",
"pos": [
0,
5
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
46,
49
]
} |
the functioning of the cyclic amp-receptor/phosphodiesterase system and its formal similarity with the synaptic acetylcholine-receptor/esterase system are discussed . | NA | {
"id": "C0031640",
"name": "phosphodiesterase",
"pos": [
43,
60
]
} | {
"id": "C0014894",
"name": "esterase",
"pos": [
135,
143
]
} |
various concentrations of l-dopa ( levodopa , l-3,4-dihydroxyphenylalanine ) were incorporated in the diets of young male swiss albino mice , and the highest concentrations to which these mice became adapted within 3 weeks were determined . | NA | {
"id": "C0023570",
"name": "levodopa",
"pos": [
35,
43
]
} | {
"id": "C0013023",
"name": "dihydroxyphenylalanine",
"pos": [
52,
74
]
} |
after 7-10 days , cells exposed to choleragen or hormone show increased size and a fibroblastic growth pattern . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
18,
23
]
} | {
"id": "C0016030",
"name": "fibroblastic",
"pos": [
83,
95
]
} |
tyrosinase ( ec 1.14.18.1 ; monophenol monooxygenase ) activity increases after 3 days in the presence of 10 ( -8 ) m hormone or 10 ( -10 ) m choleragen . | NA | {
"id": "C0012524",
"name": "tyrosinase",
"pos": [
0,
10
]
} | {
"id": "C0041484",
"name": "monophenol monooxygenase",
"pos": [
28,
52
]
} |
abrogation of secondary disease by treatment of irradiated mice with spleen cells from allogeneic neonatally thymectomized mice is possibly attributable to diminished immunologic competence of the cells grafted , followed by the development of immunological tolerance of the donor cells . | NA | {
"id": "C3485979",
"name": "cells",
"pos": [
76,
81
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
281,
286
]
} |
[ methods of prophylactic work of children 's polyclinics -- consultations aimed at lowering the incidence of broncho-pulmonary diseases of young children ] . | NA | {
"id": "C0008059",
"name": "children 's",
"pos": [
34,
45
]
} | {
"id": "C0728836",
"name": "of",
"pos": [
137,
139
]
} |
chs humans and cattle have an increased incidence of pyogenic infections , whereas chs mink are more susceptible to aleutian disease . | NA | {
"id": "C0007965",
"name": "chs",
"pos": [
0,
3
]
} | {
"id": "C0002016",
"name": "aleutian disease",
"pos": [
116,
132
]
} |
peripheral blood leukocytes ( pbl ) of 41 subjects were tested for their ability to be stimulated by herpes simplex virus antigens as measured by [ ( 3 ) h ] thymidine incorporation and lymphokine production ( i.e. , lymphocyte-derived chemotactic factor and lymphotoxin ) . | NA | {
"id": "C0024297",
"name": "lymphokine",
"pos": [
186,
196
]
} | {
"id": "C0024320",
"name": "lymphotoxin",
"pos": [
259,
270
]
} |
amino acid analysis of hydrolysates of purified mucopeptides from the variant showed that they contained 1.266 serine and 2.156 glycine residues per glutamic acid residue , compared with 0.174 serine and 3.144 glycine residues per glutamic acid residue in the mucopeptide of the parent strain . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
0,
10
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
210,
217
]
} |
endotoxin or lipopolysaccharide isolated from brucella abortus ( strain 456 ) produced a typical endotoxin-type interferon response in mice with peak levels of the inhibitor occurring 2 h after intravenous injection of the stimuli . | NA | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
13,
31
]
} | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
97,
106
]
} |
separation of specific initiation factors involved in the translation of myosin and myoglobin messenger rnas and the isolation of a new rna involved in translation . | NA | {
"id": "C0035696",
"name": "messenger rnas",
"pos": [
94,
108
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
136,
139
]
} |
in this case , the circular dna had recombined with lambda dna in the extract and thereby had become part of a polymeric structure , which by the normal packaging process could give rise to infectious particles with the imm 434 marker . | NA | {
"id": "C0012925",
"name": "circular dna",
"pos": [
19,
31
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
59,
62
]
} |
tyrosine hydroxylase is found predominantly in adrenergic neurons and related cells that synthesize dopamine , norepinephrine , and epinephrine , and tryptophan hydroxylase in cells synthesizing serotonin or melatonin . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
111,
125
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
132,
143
]
} |
comparison of the locomotor stimulant mechanisms of action of d-amphetamine and d-amphetamine plus l-dopa : possible involvement of serotonin . | NA | {
"id": "C0002658",
"name": "amphetamine",
"pos": [
64,
75
]
} | {
"id": "C0011812",
"name": "d-amphetamine",
"pos": [
80,
93
]
} |
fracture-dislocation of the posterior elements of c7 associated with bilateral pedicle fractures of c7 : a case report . | NA | {
"id": "C0332761",
"name": "fracture-dislocation",
"pos": [
0,
20
]
} | {
"id": "C0016658",
"name": "fractures",
"pos": [
87,
96
]
} |
a study of the rise and fall in circulating tetanus antitoxin in a group of 15 adults after basic and booster immunization indicates that although individuals vary greatly in their responsiveness to toxoid , the falloff in antitoxin appears to be fractionally constant for each individual , and over periods of 5 to 6 ye... | NA | {
"id": "C0039615",
"name": "tetanus antitoxin",
"pos": [
44,
61
]
} | {
"id": "C0003445",
"name": "antitoxin",
"pos": [
223,
232
]
} |
before the ifat was incorporated as a routine procedure , antisera used in the test were carefully calibrated to insure specificity . | NA | {
"id": "C0003241",
"name": "ifat",
"pos": [
11,
15
]
} | {
"id": "C0020960",
"name": "antisera",
"pos": [
58,
66
]
} |
ammonium sulfate , as well as potassium phosphate , can be used to measure solubility differences between hemoglobin s and hemoglobin a . | NA | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
106,
116
]
} | {
"id": "C0019016",
"name": "hemoglobin a",
"pos": [
123,
135
]
} |
cyclic changes in the uterine tissue content of f-prostaglandins and the role of prostaglandins in ovulation in mice . | NA | {
"id": "C0033561",
"name": "f-prostaglandins",
"pos": [
48,
64
]
} | {
"id": "C0033554",
"name": "prostaglandins",
"pos": [
81,
95
]
} |
these results confirm and extend previous biochemical findings indicating that , in the cholesterol-fed rabbit , the change from normal smooth muscle cell to foam cell is accompanied by marked physical and chemical changes of the lysosomes , including their progressive overloading with cholesteryl ester . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
88,
99
]
} | {
"id": "C0008387",
"name": "cholesteryl",
"pos": [
287,
298
]
} |
[ hydrocephalus during an ependymoma of the cauda equina with meningeal hemorrhage . possible deductions about the physiopathology of normal-pressure hydrocephalus ] . | NA | {
"id": "C0020255",
"name": "hydrocephalus",
"pos": [
2,
15
]
} | {
"id": "C0020258",
"name": "normal-pressure",
"pos": [
134,
149
]
} |
the trend of increasing frequency of autoantibodies with advancing radiographic category was most marked when the frequencies of antinuclear antibody and rheumatoid factor were combined . | NA | {
"id": "C0004358",
"name": "autoantibodies",
"pos": [
37,
51
]
} | {
"id": "C0003243",
"name": "antinuclear antibody",
"pos": [
129,
149
]
} |
the trend of increasing frequency of autoantibodies with advancing radiographic category was most marked when the frequencies of antinuclear antibody and rheumatoid factor were combined . | NA | {
"id": "C0004358",
"name": "autoantibodies",
"pos": [
37,
51
]
} | {
"id": "C0035448",
"name": "rheumatoid factor",
"pos": [
154,
171
]
} |
effect of dietary protein and amino acid mixture on protein synthesis in vitro in rat liver . | NA | {
"id": "C0012177",
"name": "dietary protein",
"pos": [
10,
25
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
52,
59
]
} |
proceedings : blood level , excretion , distribution and metabolism of 14c-triflubazam , a new 1,5-benzodiazepine , in mice and dogs . | NA | {
"id": "C0221102",
"name": "excretion",
"pos": [
28,
37
]
} | {
"id": "C0025519",
"name": "metabolism",
"pos": [
57,
67
]
} |
proceedings : the influence of spironolactone on the excretion and metabolism of 3h-digoxin in the rat . | NA | {
"id": "C0221102",
"name": "excretion",
"pos": [
53,
62
]
} | {
"id": "C0025519",
"name": "metabolism",
"pos": [
67,
77
]
} |
the effect of fenfluramine , 2,5-dimethoxy-4-methyl amphetamine ( dom ) and d-amphetamine on the concentration of serotonin and some free amino acids in the suboesophageal ganglia of helix pomatia . | NA | {
"id": "C0002658",
"name": "amphetamine",
"pos": [
52,
63
]
} | {
"id": "C0011812",
"name": "d-amphetamine",
"pos": [
76,
89
]
} |
similarly , in patients with motor neurone disease ( amyotrophic lateral sclerosis ) , the orderly pattern of recruitment was not disrupted . | NA | {
"id": "C0085084",
"name": "motor",
"pos": [
29,
34
]
} | {
"id": "C0002736",
"name": "amyotrophic lateral sclerosis",
"pos": [
53,
82
]
} |
the contractile and electrical properties of motor units in the first dorsal interosseous muscle of the hand have been studied in 26 patients with ulnar neuropathies and motor neurone disease ( amyotrophic lateral sclerosis ) . | NA | {
"id": "C0085084",
"name": "motor neurone disease",
"pos": [
170,
191
]
} | {
"id": "C0002736",
"name": "amyotrophic lateral sclerosis",
"pos": [
194,
223
]
} |
`` `` the higher risk of infant death to first order births is mainly due to the fact that such births occur predominantly to young women . the importance of the synergistic effect of maternal age and birth order is also demonstrated : for example , fifth order births to women aged 20-24 and third order births to women... | NA | {
"id": "C0011065",
"name": "deat",
"pos": [
32,
36
]
} | {
"id": "C0549159",
"name": "o",
"pos": [
22,
23
]
} |
the immunoreactive serum concentration of ethinylestradiol ( ee ) was measured by a specific radioimmunoassay after a single intramuscular administration of a combined preparation of norethindrone ( net ) and mestranol ( me ) . | NA | {
"id": "C0015011",
"name": "ethinylestradiol",
"pos": [
42,
58
]
} | {
"id": "C0025506",
"name": "mestranol",
"pos": [
209,
218
]
} |
in the presence of polyethylene glycol ( peg 6000 ) , this reaction became very fast and highly processive , and the product was positively supercoiled dna with a high superhelical density ( form i+ ) . | NA | {
"id": "C0032483",
"name": "polyethylene glycol",
"pos": [
19,
38
]
} | {
"id": "C0030775",
"name": "peg 6000",
"pos": [
41,
49
]
} |
this tachycardia appeared at times with wide qrs complexes , which made the differentiation between supraventricular and ventricular tachycardia somewhat difficult . | NA | {
"id": "C0039231",
"name": "tachycardia",
"pos": [
5,
16
]
} | {
"id": "C0042514",
"name": "ventricular tachycardia",
"pos": [
121,
144
]
} |
endothelial cell monolayers ( passages 1 and 2 ) were washed free of culture medium and exposed for 3 to 5 min to buffer or nitroglycerin ( ntg ) , isosorbide dinitrate ( isdn ) , or isosorbide-5-mononitrate ( ismn ) over a range of concentrations ( 10 ( -9 ) m to 10 ( -6 ) m ) encompassing those usually attained in vi... | NA | {
"id": "C0022252",
"name": "isosorbide dinitrate",
"pos": [
148,
168
]
} | {
"id": "C0064079",
"name": "isosorbide-5-mononitrate",
"pos": [
183,
207
]
} |
basal prostacyclin , however , was not altered by incubation with ntg ( 3.3 +/- 2.0 pg/1000 cells without drug vs 3.9 +/- 3.8 pg/1000 cells with drug , mean +/- sd ) , isdn ( 3.1 +/- 1.9 vs 3.1 +/- 2.2 ) , or ismn ( 2.0 +/- 0.9 vs 2.3 +/- 1.5 ) at 10 ( -7 ) m ( all differences ns ) . | NA | {
"id": "C0022252",
"name": "isdn",
"pos": [
168,
172
]
} | {
"id": "C0064079",
"name": "ismn",
"pos": [
209,
213
]
} |
also , long-term incubation ( 2 , 6 , and 24 hr ) with isdn and ismn did not alter prostacyclin production over control . | NA | {
"id": "C0022252",
"name": "isdn",
"pos": [
55,
59
]
} | {
"id": "C0064079",
"name": "ismn",
"pos": [
64,
68
]
} |
women were older ( p less than .01 ) and had more unstable angina ( p less than .01 ) , and class 3 or 4 angina ( p less than .01 ) . | NA | {
"id": "C0002965",
"name": "unstable angina",
"pos": [
50,
65
]
} | {
"id": "C0002962",
"name": "angina",
"pos": [
105,
111
]
} |
enhancement of the urinary excretion of non-sulphated and sulphated radioactive bile acids by sodium acetate in the bile duct obstructed rat . | NA | {
"id": "C0038720",
"name": "sulphated",
"pos": [
44,
53
]
} | {
"id": "C0074769",
"name": "sulphated",
"pos": [
58,
67
]
} |
withdrawing alcoholics had supine and standing heart rates and plasma noradrenaline and adrenaline concentrations that were higher than in abstinent alcoholics or control subjects . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
70,
83
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
88,
98
]
} |
abstinent alcoholics without orthostatic hypotension had higher basal and standing concentrations of noradrenaline than control subjects but normal heart rates and adrenaline concentrations . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
101,
114
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
164,
174
]
} |
the effect of bicarbonate ( nahco3 ) feeding on intestinal absorption of calcium and phosphorus and vitamin d metabolism was investigated . | NA | {
"id": "C0005367",
"name": "bicarbonate",
"pos": [
14,
25
]
} | {
"id": "C0074722",
"name": "nahco3",
"pos": [
28,
34
]
} |
exacerbation of wheezing by exposure to cold air or following the ingestion of a drug , and asthma variants , such as nocturnal cough responsive to bronchodilator agents or exercise-induced asthma , all support the diagnosis of asthma . | NA | {
"id": "C0004099",
"name": "exercise-induced asthma",
"pos": [
173,
196
]
} | {
"id": "C0004096",
"name": "asthma",
"pos": [
228,
234
]
} |
as anticipated , the response to lats-b is inhibited by antihuman immunoglobulin g ( igg ) and that due to 22a6 by antimouse igg . | NA | {
"id": "C0023979",
"name": "lats",
"pos": [
33,
37
]
} | {
"id": "C0020852",
"name": "igg",
"pos": [
125,
128
]
} |
we employed a bioassay [ ( 3h ] thymidine incorporation into dna of chick embryo fibroblasts ) , a displacement assay [ competition for binding of radiolabeled multiplication-stimulating activity ( rat insulin-like growth factor ii ) to the somatomedin-binding protein ] for total somatomedin , and the ria for somatomed... | NA | {
"id": "C0021666",
"name": "insulin-like growth",
"pos": [
202,
221
]
} | {
"id": "C0037657",
"name": "somatomedin",
"pos": [
311,
322
]
} |
we employed a bioassay [ ( 3h ] thymidine incorporation into dna of chick embryo fibroblasts ) , a displacement assay [ competition for binding of radiolabeled multiplication-stimulating activity ( rat insulin-like growth factor ii ) to the somatomedin-binding protein ] for total somatomedin , and the ria for somatomed... | NA | {
"id": "C0037657",
"name": "somatomedin",
"pos": [
241,
252
]
} | {
"id": "C0021665",
"name": "somatomedin-c",
"pos": [
311,
324
]
} |
the somatomedin secreted by fetal hepatocytes exhibited immunological cross-reactivity with human somatomedin-c , but the levels were 500-fold less than those measured by our displacement assay . | NA | {
"id": "C0037657",
"name": "somatomedin",
"pos": [
4,
15
]
} | {
"id": "C0021665",
"name": "somatomedin-c",
"pos": [
98,
111
]
} |
the study examined the effect of estrogen priming on progesterone ( p4 ) -induced lhrh release , the tissue site of action of p4 , and the effect of 5 alpha-dihydroxyprogesterone ( 5 alpha-dhp ) on lhrh release from hypothalamic fragments superfused in vitro . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
53,
65
]
} | {
"id": "C0002328",
"name": "dihydroxyprogesterone",
"pos": [
157,
178
]
} |
the synthesis involves 1 ) oxidation to the 21-dehydro compound with methanolic cupric acetate , 2 ) further oxidation to the acid with methylene blue in the presence of kcn at ph 6.5 , 3 ) esterification with diazomethane in the presence of methanol or ethanol , to produce the methyl ester of ta ( tame ) or ethyl este... | NA | {
"id": "C0001963",
"name": "methanol",
"pos": [
69,
77
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
254,
261
]
} |
proinsulin was approximately 10-100 times less effective than insulin in stimulating collagen synthesis , whereas porcine relaxin and c-peptide were ineffective . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
0,
10
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
62,
69
]
} |
proinsulin was approximately 10-100 times less effective than insulin in stimulating collagen synthesis , whereas porcine relaxin and c-peptide were ineffective . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
0,
10
]
} | {
"id": "C0006558",
"name": "c-peptide",
"pos": [
134,
143
]
} |
it has been recently demonstrated that cortisol can be metabolized , producing 18-hydroxycortisol and 18-oxocortisol , following the same pathway by which corticosterone is transformed into 18-hydroxycorticosterone and aldosterone . | NA | {
"id": "C0010124",
"name": "corticosterone",
"pos": [
155,
169
]
} | {
"id": "C0000172",
"name": "18-hydroxycorticosterone",
"pos": [
190,
214
]
} |
this assay has been used to quantify and to characterize insulin antibody of sera from a large number of diabetic subjects , ranging from insulin resistant to those who had received only highly purified and human insulins . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
57,
64
]
} | {
"id": "C0795635",
"name": "human insulins",
"pos": [
207,
221
]
} |
one striking finding was a change in the bile acid composition : increases were recorded in cholic and deoxycholic acids while decreases occurred in bile acids derived from chenodeoxycholic acid , such as beta-muricholic and ursodeoxycholic acids in the bile and alpha-muricholic , beta-muricholic , omega-muricholic , a... | NA | {
"id": "C0011479",
"name": "deoxycholic acids",
"pos": [
103,
120
]
} | {
"id": "C0008024",
"name": "chenodeoxycholic acid",
"pos": [
173,
194
]
} |
competition studies using in vitro enzymatically split forms of proinsulin demonstrated that the major antigenic determinant recognized was the junctional region between the b-chain of insulin and the c-peptide . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
64,
74
]
} | {
"id": "C0006558",
"name": "c-peptide",
"pos": [
201,
210
]
} |
two strains of mice ( c57bl/10scn and c3h/hej ) that carry the same mutant lipopolysaccharide gene ( lpsd ) which makes them resistant to the toxic effects of endotoxin ( lps ) are also partially resistant to the hepatotoxic effects of d-galactosamine . | NA | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
159,
168
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
171,
174
]
} |
in contrast , monooctanoin , an established gallstone solvent , required greater than 50 h to dissolve similar stones . | NA | {
"id": "C0008350",
"name": "gallstone",
"pos": [
44,
53
]
} | {
"id": "C0006736",
"name": "stones",
"pos": [
111,
117
]
} |
ursodeoxycholic acid , as well as cholic , chenodeoxycholic , and deoxycholic acids , were analyzed by a highly specific method based on isotope dilution-mass spectrometry . | NA | {
"id": "C0042105",
"name": "ursodeoxycholic acid",
"pos": [
0,
20
]
} | {
"id": "C0011479",
"name": "deoxycholic acids",
"pos": [
66,
83
]
} |
that this hyperinsulinemia represented in vivo insulin resistance was supported by the glucose and insulin responses in four individuals to an iv glucose bolus analyzed by the minimal modeling technique . | NA | {
"id": "C0020459",
"name": "hyperinsulinemia",
"pos": [
10,
26
]
} | {
"id": "C0021655",
"name": "insulin resistance",
"pos": [
47,
65
]
} |
divergent influences of the structurally dissimilar calcium entry blockers , diltiazem and verapamil , on thyrotropin- and gonadotropin-releasing hormone-stimulated anterior pituitary hormone secretion in man . | NA | {
"id": "C0040160",
"name": "thyrotropin",
"pos": [
106,
117
]
} | {
"id": "C0032016",
"name": "hormone",
"pos": [
184,
191
]
} |
the results indicate that 1 ) the abs produced by patients receiving long term hgh therapy as well as abs of goat , rabbit , and mouse origin recognized the various hgh epitopes defined by the mabs ; | NA | {
"id": "C0003241",
"name": "abs",
"pos": [
34,
37
]
} | {
"id": "C0003250",
"name": "mabs",
"pos": [
193,
197
]
} |
the broad overlap of reactivity to nucleic acid antigens among individual anti-dna autoantibodies found in two clinically different autoimmune diseases , namely ra and sle , suggests that the pathogenicity of anti-dna autoantibodies may bear no relationship to their nucleic acid antigen-binding characteristics . | NA | {
"id": "C0004364",
"name": "autoimmune diseases",
"pos": [
132,
151
]
} | {
"id": "C0024141",
"name": "sle",
"pos": [
168,
171
]
} |
by using the mixed leukocyte reaction ( mlr ) as a model system , we have shown previously that alloantigen-primed leu-3+ cells induce autologous leu-2+ cells to differentiate into suppressor t cells that specifically inhibit the response of fresh t cells to the original allogeneic stimulator cells . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
122,
127
]
} | {
"id": "C3485979",
"name": "allogeneic",
"pos": [
272,
282
]
} |
the cell populations examined included peripheral blood mononuclear cells ( pbmc ) and highly purified b cell and helper t cell populations obtained by negative selection by using monoclonal antibodies and a fluorescence-activated cell sorter . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
4,
8
]
} | {
"id": "C1321301",
"name": "peripheral blood mononuclear cells",
"pos": [
39,
73
]
} |
in contrast to these results with pbmc , ifn-alpha con1 increased the ig production of purified b cells 10- to 20-fold in the presence of pwm . | NA | {
"id": "C1321301",
"name": "pbmc",
"pos": [
34,
38
]
} | {
"id": "C0007634",
"name": "the",
"pos": [
122,
125
]
} |
although interferons exhibit mif activities , there are apparently other cytokines , without antiviral activity , that also have mif activities . | NA | {
"id": "C0021747",
"name": "interferons",
"pos": [
9,
20
]
} | {
"id": "C0079189",
"name": "cytokines",
"pos": [
73,
82
]
} |
consistent with these observations , culturing pbmc with pha plus wga markedly decreased the number of high-affinity il 2 receptor per cell , as determined by binding of purified [ 3h ] il 2 , relative to cultures containing pha alone . | NA | {
"id": "C1321301",
"name": "pbmc",
"pos": [
47,
51
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
135,
139
]
} |
at position 152 , glu in donor m17 had changed to va1 in donor e1 , and at position 156 , leu in donor m17 had changed to gln in donor e1 . | NA | {
"id": "C0061472",
"name": "glu",
"pos": [
18,
21
]
} | {
"id": "C0017797",
"name": "gln",
"pos": [
122,
125
]
} |
identification of epitopes associated with hcg and the beta hcg carboxyl terminus by monoclonal antibodies produced against a synthetic peptide . | NA | {
"id": "C0018062",
"name": "hcg",
"pos": [
43,
46
]
} | {
"id": "C0106132",
"name": "beta hcg",
"pos": [
55,
63
]
} |
five antibodies , designated fb01 , fb02 , fb03 , fb04 , and fb00 , were developed and analyzed with respect to affinity and specificity for epitopes on human chorionic gonadotropin ( hcg ) and beta hcg by enzyme-linked immunoabsorbent and radioimmunoassays ( ria ) . | NA | {
"id": "C0018062",
"name": "human",
"pos": [
153,
158
]
} | {
"id": "C0106132",
"name": "beta hcg",
"pos": [
194,
202
]
} |
one antibody , namely fb00 , bound only to the synthetic peptide , whereas all other monoclonal antibodies recognized either free native beta hcg or both beta hcg and hcg . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
4,
12
]
} | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
85,
106
]
} |
indeed , one epitope recognized by fb01 is located between residues 109 and 118 , whereas another antigenic region recognized by fb04 appears to be present on the 109-121 portion of the molecule near or at position 118 . | NA | {
"id": "C0003316",
"name": "epitope",
"pos": [
13,
20
]
} | {
"id": "C0003320",
"name": "antigenic",
"pos": [
98,
107
]
} |
with the use of such antibodies , two- and three-site monoclonal ria were developed and employed to detect free beta hcg and hcg in sera of patients with choriocarcinoma . | NA | {
"id": "C0106132",
"name": "beta hcg",
"pos": [
112,
120
]
} | {
"id": "C0018062",
"name": "hcg",
"pos": [
125,
128
]
} |
these assays may be useful in the detection of beta hcg- and hcg-producing tumors and subsequent monitoring of patients in response to surgery and/or chemotherapy . | NA | {
"id": "C0106132",
"name": "beta hcg",
"pos": [
47,
55
]
} | {
"id": "C0018062",
"name": "hcg",
"pos": [
61,
64
]
} |
tubular poly c9 , as part of c5b-9 , could also be generated on rabbit erythrocytes by using whole human serum as a complement source . | NA | {
"id": "C0009545",
"name": "c5b-9",
"pos": [
29,
34
]
} | {
"id": "C0009498",
"name": "complement",
"pos": [
116,
126
]
} |
it was first established that the c3 associated with m+ streptococci was not able to promote adherence to cells bearing the complement receptors cr1 and cr3 under conditions in which m- streptococci readily attached . | NA | {
"id": "C0034793",
"name": "complement receptors",
"pos": [
124,
144
]
} | {
"id": "C0079785",
"name": "cr3",
"pos": [
153,
156
]
} |
although the proteases from the bifidobacterium and the streptococcus pneumoniae showed the characteristics of typical iga1 proteases , cleaving the iga of only the iga1 subclass , the protease from clostridium sp . revealed a dual substrate specificity , in that it cleaved both iga1 and iga2 of the a2m ( 1 ) allotype ... | NA | {
"id": "C0030940",
"name": "proteases",
"pos": [
13,
22
]
} | {
"id": "C0030946",
"name": "protease",
"pos": [
185,
193
]
} |
this antigen appeared to be located on the plasma membrane of t. congolense , but the epitope was not exposed on the surface of living bloodstream or procyclic organisms . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
5,
12
]
} | {
"id": "C0003316",
"name": "epitope",
"pos": [
86,
93
]
} |
the clone , pc4al1 , detects a dna polymorphism of the c4 genes in southern blot hybridization experiments and established the genotype of a lymphoblastoid cell line , lcl 721 , as heterozygous for the c4 dna patterns . | NA | {
"id": "C0000702",
"name": "a dna",
"pos": [
29,
34
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
205,
208
]
} |
target-specific antisera , used to mediate the killing of t. pyriformis by ncc , were required only for immobilizing the targets , and did not function in an antibody-dependent cell-mediated ( adcc ) -like mechanism . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
16,
24
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
158,
166
]
} |
the effect of gtp was mimicked by its nonhydrolyzable analogue 5'-guanylylimidodiphosphate but not by atp and occurred when diazepam , but not when ro 15-1788 , was used as the displacer . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
14,
17
]
} | {
"id": "C0018366",
"name": "guanylylimidodiphosphate",
"pos": [
66,
90
]
} |
a phorbol ester that activates protein kinase c , 12-o-tetradecanoylphorbol-13-acetate ( tpa ) , caused enhancement of both [ 3h ] arachidonic acid release and exocytosis . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
2,
15
]
} | {
"id": "C0039654",
"name": "12-o-tetradecanoylphorbol-13-acetate",
"pos": [
50,
86
]
} |
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