text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
in brain , the [ 3h ] dihydropyridine isothiocyanate labels sites that correspond in number and pharmacologic characteristics to binding sites for the classic calcium entry blocker , [ 3h ] nitrendipine . | NA | {
"id": "C0012315",
"name": "dihydropyridine",
"pos": [
22,
37
]
} | {
"id": "C0028127",
"name": "nitrendipine",
"pos": [
190,
202
]
} |
the sidedness of cdp-choline:1,2-diradylglycerol choline phosphotransferase ( ec 2.7.8.2 ) and of the choline base-exchange activity has been studied in rat brain microsomal vesicles . | NA | {
"id": "C0010725",
"name": "cdp-choline",
"pos": [
17,
28
]
} | {
"id": "C0008405",
"name": "choline",
"pos": [
102,
109
]
} |
it is therefore concluded that cdp-choline:1,2-diradylglycerol choline phosphotransferase and the choline base-exchange activity are localized on the outer surface of rat brain microsomal vesicles . | NA | {
"id": "C0010725",
"name": "cdp-choline",
"pos": [
31,
42
]
} | {
"id": "C0008405",
"name": "choline",
"pos": [
98,
105
]
} |
microscopically , mixed adenoma was diagnosed in six cases , basophilic adenoma in three patients , and chromophobe adenoma in one patient . | NA | {
"id": "C0001430",
"name": "adenoma",
"pos": [
24,
31
]
} | {
"id": "C0001431",
"name": "basophilic adenoma",
"pos": [
61,
79
]
} |
microscopically , mixed adenoma was diagnosed in six cases , basophilic adenoma in three patients , and chromophobe adenoma in one patient . | NA | {
"id": "C0001430",
"name": "adenoma",
"pos": [
24,
31
]
} | {
"id": "C0001432",
"name": "chromophobe adenoma",
"pos": [
104,
123
]
} |
this study shows a good correlation among the cell counts positive for antigen , histological findings and stage of disease , and provides the basis for a prospective study that may help to determine the role of abo ( h ) isoantigen measurement in bladder tumor patients . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
71,
78
]
} | {
"id": "C0022145",
"name": "isoantigen",
"pos": [
222,
232
]
} |
the authors conclude that ct is useful in the evaluation of a suspected synovial cyst when its position is atypical or when arthrography fails to demonstrate or completely delineate the cyst . | NA | {
"id": "C0085648",
"name": "synovial cyst",
"pos": [
72,
85
]
} | {
"id": "C0010709",
"name": "cyst",
"pos": [
186,
190
]
} |
planar bone scintigraphy ( pbs ) and single-photon emission computed tomography ( spect ) were compared in 19 adults with radiographic evidence of spondylolysis and/or spondylolisthesis . | NA | {
"id": "C0038018",
"name": "spondylolysis",
"pos": [
147,
160
]
} | {
"id": "C0038016",
"name": "spondylolisthesis",
"pos": [
168,
185
]
} |
in 6 patients , spondylolysis or spondylolisthesis was unrelated to low back pain , and spect images of the posterior neural arch were normal . | NA | {
"id": "C0038018",
"name": "spondylolysis",
"pos": [
16,
29
]
} | {
"id": "C0038016",
"name": "spondylolisthesis",
"pos": [
33,
50
]
} |
the authors conclude that when spondylolysis or spondylolisthesis is the cause of low back pain , pars defects are frequently heralded by increased scintigraphic activity which is best detected and localized by spect . | NA | {
"id": "C0038018",
"name": "spondylolysis",
"pos": [
31,
44
]
} | {
"id": "C0038016",
"name": "spondylolisthesis",
"pos": [
48,
65
]
} |
increased risk of mortality was associated with lower birth weight and lower weight for gestational age , males , initial serum ph less than 7.30 , delay in surgical treatment and feeding tube perforation . | NA | {
"id": "C0005612",
"name": "birth weight",
"pos": [
54,
66
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
77,
83
]
} |
a survey of the mode of presentation , surgical findings , and pathology of 135 published cases of intestinal obstruction in children demonstrates that a closed loop , with or without volvulus , is the most common complication of remnant bands . | NA | {
"id": "C0021843",
"name": "of",
"pos": [
9,
11
]
} | {
"id": "C0042961",
"name": "volvulus",
"pos": [
184,
192
]
} |
off sonographic features distinguishing randomly selected cases of simple hydronephrosis ( 34 patients ) from pyonephrosis ( 16 patients ) were reviewed in 50 patients . | NA | {
"id": "C0020295",
"name": "hydronephrosis",
"pos": [
74,
88
]
} | {
"id": "C0034216",
"name": "pyonephrosis",
"pos": [
110,
122
]
} |
in order to develop a rapid , simple test to differentiate toxic naphthalene from the less toxic mothball ingredient paradichlorobenzene , both types of mothballs were dissolved in isopropyl alcohol , ethanol , methanol , and turpentine . | NA | {
"id": "C0022237",
"name": "isopropyl alcohol",
"pos": [
181,
198
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
212,
219
]
} |
in order to develop a rapid , simple test to differentiate toxic naphthalene from the less toxic mothball ingredient paradichlorobenzene , both types of mothballs were dissolved in isopropyl alcohol , ethanol , methanol , and turpentine . | NA | {
"id": "C0001962",
"name": "ethanol",
"pos": [
201,
208
]
} | {
"id": "C0001963",
"name": "methanol",
"pos": [
211,
219
]
} |
isopropyl alcohol , ethanol , and methanol did not differentially dissolve the mothballs fast enough to provide a useful test . | NA | {
"id": "C0022237",
"name": "isopropyl alcohol",
"pos": [
0,
17
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
35,
42
]
} |
isopropyl alcohol , ethanol , and methanol did not differentially dissolve the mothballs fast enough to provide a useful test . | NA | {
"id": "C0001962",
"name": "ethanol",
"pos": [
20,
27
]
} | {
"id": "C0001963",
"name": "methanol",
"pos": [
34,
42
]
} |
neutrophils and u937 cells had 143 and 52 times greater angiotensin i-converting capability than cultured monocytes or peripheral blood mononuclear cells , suggesting the relative importance of mobile cells containing cathepsin g in the local generation of angiotensin ii . | NA | {
"id": "C1321301",
"name": "peripheral blood mononuclear",
"pos": [
119,
147
]
} | {
"id": "C0007634",
"name": "the",
"pos": [
233,
236
]
} |
in our studies , the polymer fraction in sickle red cells was determined from reported mean values for hemoglobin composition and mean corpuscular hemoglobin concentration ( mchc ) in 12 groups of patients with sickle hemoglobinopathies ( homozygotes for hbs , with and without coexistent alpha-thalassemia or various fo... | NA | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
103,
113
]
} | {
"id": "C0019016",
"name": "hba",
"pos": [
464,
467
]
} |
pseudotumour cerebri is a disorder characterized by elevated intracranial pressure in the absence of hydrocephalus and intracranial mass lesions . | NA | {
"id": "C0033845",
"name": "pseudotumour cerebri",
"pos": [
0,
20
]
} | {
"id": "C0151740",
"name": "elevated intracranial",
"pos": [
52,
73
]
} |
in vitro and in vivo studies both show that leucine is the significant controlling branched-chain amino acid in the tpn mixture , and adequate leucine content is a crucial component of effective tpn . | NA | {
"id": "C0002521",
"name": "branched-chain amino acid",
"pos": [
83,
108
]
} | {
"id": "C0023401",
"name": "leucine",
"pos": [
143,
150
]
} |
measurements were made , using semiautomatic electronic planimetry , of nuclear and nucleolar parameters of cytologic preparations from 18 cases of centroblastic and 9 cases of b-immunoblastic non-hodgkin 's lymphomas , in order to determine whether these two subgroups of large cell lymphoma could be differentiated obj... | NA | {
"id": "C0079746",
"name": "immunoblastic",
"pos": [
179,
192
]
} | {
"id": "C0024305",
"name": "non-hodgkin 's",
"pos": [
193,
207
]
} |
pheochromocytomas were diagnosed by ultrasound as part of a multiple endocrine neoplasia ( men iia ) in two patients with mct . | NA | {
"id": "C0027662",
"name": "multiple endocrine neoplasia",
"pos": [
60,
88
]
} | {
"id": "C0025268",
"name": "men iia",
"pos": [
91,
98
]
} |
the present study evaluates the effect of thymine and uracil , which are thought to be catabolized by the same enzymes as fura , on the metabolism and transmembrane distribution of fura in isolated rat hepatocytes . | NA | {
"id": "C0040087",
"name": "thymine",
"pos": [
42,
49
]
} | {
"id": "C0041917",
"name": "uracil",
"pos": [
54,
60
]
} |
the present study evaluates the effect of thymine and uracil , which are thought to be catabolized by the same enzymes as fura , on the metabolism and transmembrane distribution of fura in isolated rat hepatocytes . | NA | {
"id": "C0041917",
"name": "uracil",
"pos": [
54,
60
]
} | {
"id": "C0016360",
"name": "fura",
"pos": [
181,
185
]
} |
following simulataneous exposure of cells for 5 min to 30 microm [ 6-3h ] fura and increasing concentrations of either thymine or uracil , dihydrofluorouracil ( fuh2 ) levels decreased in a concentration-dependent manner , and the concentration determined for 50 % inhibition of fura catabolism was 8.0 +/- 0.3 ( s.d . )... | NA | {
"id": "C0016360",
"name": "fura",
"pos": [
74,
78
]
} | {
"id": "C0041917",
"name": "uracil",
"pos": [
362,
368
]
} |
following simulataneous exposure of cells for 5 min to 30 microm [ 6-3h ] fura and increasing concentrations of either thymine or uracil , dihydrofluorouracil ( fuh2 ) levels decreased in a concentration-dependent manner , and the concentration determined for 50 % inhibition of fura catabolism was 8.0 +/- 0.3 ( s.d . )... | NA | {
"id": "C0040087",
"name": "thymine",
"pos": [
119,
126
]
} | {
"id": "C0041917",
"name": "uracil",
"pos": [
362,
368
]
} |
analysis of intracellular and extracellular 3h from 1 min to 2 hr after simultaneous incubation of the hepatocytes with 30 microm fura and thymine ( or uracil ) in a 1:7 molar ratio resulted in a decrease of intracellular and extracellular fuh2 and alpha-fluoro-beta-alanine ( fbal ) , while alpha-fluoro-beta-ureidoprop... | NA | {
"id": "C0016360",
"name": "fura",
"pos": [
130,
134
]
} | {
"id": "C0041917",
"name": "uracil",
"pos": [
152,
158
]
} |
analysis of intracellular and extracellular 3h from 1 min to 2 hr after simultaneous incubation of the hepatocytes with 30 microm fura and thymine ( or uracil ) in a 1:7 molar ratio resulted in a decrease of intracellular and extracellular fuh2 and alpha-fluoro-beta-alanine ( fbal ) , while alpha-fluoro-beta-ureidoprop... | NA | {
"id": "C0040087",
"name": "thymine",
"pos": [
139,
146
]
} | {
"id": "C0041917",
"name": "uracil",
"pos": [
152,
158
]
} |
unmetabolized fura ( not detected in the absence of thymine or uracil ) was detected intracellularly in the presence of thymine or uracil and was accompanied by the appearance of a novel metabolite , preliminarily identified as a glucuronide of the fura base which reached intracellular levels of 44 +/- 9.76 and 27.45 +... | NA | {
"id": "C0016360",
"name": "fura",
"pos": [
14,
18
]
} | {
"id": "C0041917",
"name": "uracil",
"pos": [
365,
371
]
} |
unmetabolized fura ( not detected in the absence of thymine or uracil ) was detected intracellularly in the presence of thymine or uracil and was accompanied by the appearance of a novel metabolite , preliminarily identified as a glucuronide of the fura base which reached intracellular levels of 44 +/- 9.76 and 27.45 +... | NA | {
"id": "C0040087",
"name": "thymine",
"pos": [
52,
59
]
} | {
"id": "C0041917",
"name": "uracil",
"pos": [
365,
371
]
} |
the formation of fura anabolites was insignificant in the presence of thymine and uracil , and incorporation of fura into rna was not enhanced . | NA | {
"id": "C0040087",
"name": "thymine",
"pos": [
70,
77
]
} | {
"id": "C0041917",
"name": "uracil",
"pos": [
82,
88
]
} |
the formation of fura anabolites was insignificant in the presence of thymine and uracil , and incorporation of fura into rna was not enhanced . | NA | {
"id": "C0041917",
"name": "uracil",
"pos": [
82,
88
]
} | {
"id": "C0016360",
"name": "fura",
"pos": [
112,
116
]
} |
these studies indicate that thymine is a more potent modulator of fura catabolism in hepatocytes than is uracil . | NA | {
"id": "C0040087",
"name": "thymine",
"pos": [
28,
35
]
} | {
"id": "C0041917",
"name": "uracil",
"pos": [
105,
111
]
} |
these studies indicate that thymine is a more potent modulator of fura catabolism in hepatocytes than is uracil . | NA | {
"id": "C0016360",
"name": "fura",
"pos": [
66,
70
]
} | {
"id": "C0041917",
"name": "uracil",
"pos": [
105,
111
]
} |
the expected , normal profile of cyclic amp accumulation in response to beta-adrenergic receptor agonists was epinephrine greater than norepinephrine greater than phenylephrine . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
110,
121
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
135,
149
]
} |
norepinephrine produced a greater accumulation of cyclic amp than epinephrine , and phenylephrine stimulated a much greater than normal response . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
0,
14
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
66,
77
]
} |
in addition , the accumulation of cyclic amp in ay-34 cells in response to stimulation by epinephrine and norepinephrine , but not phenylephrine , was unusually great . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
90,
101
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
106,
120
]
} |
normal quail embryonic fibroblasts and quail fibrosarcoma ( qt-35 ) and normal rat kidney cells and rat fibrosarcoma ( from rat fibroblasts chemically transformed by nitroquinoline oxide ) were recorded intracellularly using high-impedance micropipets . | NA | {
"id": "C0007634",
"name": "normal",
"pos": [
0,
6
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
128,
139
]
} |
the heavily glycosylated and polydisperse nature of this antigen and the results of various enzyme treatments suggest that the du-pan-2 epitope is expressed on a mucin-like molecule . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
57,
64
]
} | {
"id": "C0003316",
"name": "epitope",
"pos": [
136,
143
]
} |
the cytotoxic activity and cellular association of gold from auranofin were dose , time , and temperature dependent ; | NA | {
"id": "C0018026",
"name": "gold",
"pos": [
51,
55
]
} | {
"id": "C0004320",
"name": "auranofin",
"pos": [
61,
70
]
} |
and binding of auranofin gold to serum proteins markedly decreased cellular uptake of gold and cytotoxicity of auranofin in vitro . | NA | {
"id": "C0004320",
"name": "auranofin",
"pos": [
15,
24
]
} | {
"id": "C0018026",
"name": "gold",
"pos": [
86,
90
]
} |
ethanesulfonic acid compounded with alpha- ( 2-chloro-4- [ 4,6-diamino-2,2-dimethyl-s-triazine-1- ( 2h ) -yl ] phenoxyl ) -n , n-dimethyl-m-toluamide ( 1:1 ) ] and trimetrexate ( nsc 249008 , jb-11 , tmq ; 2,4-diamino-6- [ ( 3,4,5-trimethoxyanilino ) methyl ] quinazoline ) , two nonclassical folate antagonists . | NA | {
"id": "C0085176",
"name": "tmq",
"pos": [
200,
203
]
} | {
"id": "C0034407",
"name": "quinazoline",
"pos": [
260,
271
]
} |
the changes of expression of some antigens on exposure of cells to dibutyryl adenosine 3'-5'-cyclic monophosphoric acid may enable us to have a greater understanding of the differentiation of neuroblastoma to a more mature ganglioneuroblastoma phenotype . | NA | {
"id": "C0027819",
"name": "neuroblastoma",
"pos": [
192,
205
]
} | {
"id": "C0206718",
"name": "ganglioneuroblastoma",
"pos": [
223,
243
]
} |
we conclude that the combined use of these two monoclonal antibodies detects a wider range of sera from cancer patients than the use of a single antibody alone . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
47,
68
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
145,
153
]
} |
to attempt to increase the potential of tgua to serve as an inducer of parental hl-60 leukemia cells , physiological purine and pyrimidine nucleosides were tested for their ability to protect hl-60 cells against tgua-induced cytotoxicity . | NA | {
"id": "C0034140",
"name": "purine",
"pos": [
117,
123
]
} | {
"id": "C0039902",
"name": "tgua",
"pos": [
212,
216
]
} |
we conclude that mitoxantrone is active in patients with acute promyelocytic leukemia and that these patients should also be included in the planned prospective randomized trials comparing daunorubicin and mitoxantrone in combination with cytarabine in previously untreated patients with acute nonlymphoblastic leukemia ... | NA | {
"id": "C0023487",
"name": "acute promyelocytic leukemia",
"pos": [
57,
85
]
} | {
"id": "C0023467",
"name": "acute nonlymphoblastic leukemia",
"pos": [
288,
319
]
} |
the primary clinical arrhythmia was sustained ventricular tachycardia in 32 patients , ventricular fibrillation in 20 patients , and both ventricular tachycardia and fibrillation in 18 patients . | NA | {
"id": "C0003811",
"name": "arrhythmia",
"pos": [
21,
31
]
} | {
"id": "C0042510",
"name": "ventricular",
"pos": [
138,
149
]
} |
over the short term , captopril decreased arterial blood pressure ( from 110 +/- 18 to 98 +/- 18 mm hg , p less than .01 ) without increasing heart rate ( 75 +/- 15 vs 74 +/- 15 beats/min ) , arterial concentrations of epinephrine ( 0.38 +/- 0.28 vs 0.34 +/- 0.25 nm ) or norepinephrine ( 2.7 +/- 2.1 vs 2.8 +/- 2.1 nm )... | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
219,
230
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
342,
356
]
} |
thus initial ck release indicative of infarction is detectable within 1 hr after the onset of ischemia by quantification of plasma mm ck isoforms . | NA | {
"id": "C0021308",
"name": "infarction",
"pos": [
38,
48
]
} | {
"id": "C0022116",
"name": "ischemia",
"pos": [
94,
102
]
} |
we absorbed the serum with a derivative of nicotine coupled to the carrier protein via a chemical bridge similar to that used to form the cotinine/carrier protein immunogen . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
75,
82
]
} | {
"id": "C0007292",
"name": "carrier protein",
"pos": [
147,
162
]
} |
preliminary studies , including amino acid analysis , characterization of uronic acids , and ultraviolet spectroscopy , show that the molecule contains glycine , a uronic acid , and an aromatic ring . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
32,
42
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
152,
159
]
} |
healthy subjects and patients with the irritable colon syndrome ( ics ) were exposed to three standardized stressful conditions : ( 1 ) ice-water immersion , ( 2 ) stroop stimulus differentiation test , and ( 3 ) ball sorting . | NA | {
"id": "C0020746",
"name": "ice",
"pos": [
136,
139
]
} | {
"id": "C0043047",
"name": "water",
"pos": [
140,
145
]
} |
in healthy controls , colonic motility increased after the first exposure to ice-water immersion ( p less than 0.05 ) , stroop test ( p less than 0.05 ) , or ball sorting . | NA | {
"id": "C0020746",
"name": "ice",
"pos": [
77,
80
]
} | {
"id": "C0043047",
"name": "water",
"pos": [
81,
86
]
} |
these results show that patients with chronic airways obstruction and pulmonary emphysema respond to a single dose of 100 mg almitrine by an increase of pao2 equivalent to that achieved by administering 1.0 l/min of o2 via the nose . | NA | {
"id": "C0024117",
"name": "chronic airways obstruction",
"pos": [
38,
65
]
} | {
"id": "C0034067",
"name": "pulmonary emphysema",
"pos": [
70,
89
]
} |
the cell-surface glycoproteins consist of two vectorially labelled major components present in a fixed molar ratio : the thy-1 glycoprotein and a non-h-2 glycoprotein of 55 kd . | NA | {
"id": "C0025248",
"name": "cell-surface glycoproteins",
"pos": [
4,
30
]
} | {
"id": "C0017968",
"name": "glycoprotein",
"pos": [
154,
166
]
} |
the membrane-associated proteins are not vectorially labelled , and form a complex group of proteins in the 30-70 kd range . | NA | {
"id": "C0025252",
"name": "membrane-associated proteins",
"pos": [
4,
32
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
92,
100
]
} |
the fraction of amino-acyl-trna synthetases bound to the detergent-insoluble cytoskeletal framework obtained after extraction of nrk cells by 0.1 % triton x-100 was estimated , by activity measurements , to about 80 % for phenylalanyl-trna synthetase and 40 % for the high-molecular-weight ( hmw ) complex containing the... | NA | {
"id": "C0031460",
"name": "phenylalanyl-trna",
"pos": [
222,
239
]
} | {
"id": "C0002529",
"name": "aminoacyl-trna synthetases",
"pos": [
327,
353
]
} |
the fraction of amino-acyl-trna synthetases bound to the detergent-insoluble cytoskeletal framework obtained after extraction of nrk cells by 0.1 % triton x-100 was estimated , by activity measurements , to about 80 % for phenylalanyl-trna synthetase and 40 % for the high-molecular-weight ( hmw ) complex containing the... | NA | {
"id": "C0061472",
"name": "glutamic acid",
"pos": [
367,
380
]
} | {
"id": "C0017797",
"name": "glutamine",
"pos": [
419,
428
]
} |
since very little information about the levels of these pools in senescing cells is currently available , an analysis of deoxyribonucleotide levels was carried out in young , old and very old normal human diploid fibroblasts , as well as in a variant human fibroblast strain with an altered replicative life span . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
75,
80
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
257,
267
]
} |
in two independent experiments 17 alpha-20 beta-dihydroxyprogesterone ( dhp ) was most active followed in turn by 17 alpha-hydroxyprogesterone ( hp ) and progesterone ( p ) . | NA | {
"id": "C0002328",
"name": "dihydroxyprogesterone",
"pos": [
48,
69
]
} | {
"id": "C0033308",
"name": "progesterone",
"pos": [
154,
166
]
} |
in addition , the nf-m-positive mitotic cells , when observed in anaphase and telophase , had nf-m-positive material associated with both emerging daughter cells and the migrating neuroblasts were frequently found in closely associated pairs , consistent with the suggestion that these precursor cells undergo a symmetri... | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
40,
45
]
} | {
"id": "C0018956",
"name": "precursor cells",
"pos": [
286,
301
]
} |
cholecystokinin immunoreactivity cochromatographing with cholecystokinin-octapeptide was responsible for 50 % -60 % of circulating cholecystokinin in normals and in treated patients but the small amount of cholecystokinin that was released in untreated patients with celiac disease cochromatographed with cholecystokinin... | NA | {
"id": "C0037167",
"name": "cholecystokinin",
"pos": [
0,
15
]
} | {
"id": "C0008328",
"name": "cholecystokinin",
"pos": [
305,
320
]
} |
such local malignancies as bowen 's disease , which may be pigmented and multifocal in this region , and invasive squamous cell carcinoma may first manifest themselves as pruritus ani . | NA | {
"id": "C0006079",
"name": "bowen 's disease",
"pos": [
27,
43
]
} | {
"id": "C0007137",
"name": "squamous cell carcinoma",
"pos": [
114,
137
]
} |
because prostaglandins are known to inhibit natural killer activity , pge was measured in 20 collagenase supernatants by radioimmunoassay and found to be high at 27.5 +/- 4.0 ng/ml . | NA | {
"id": "C0033554",
"name": "prostaglandins",
"pos": [
8,
22
]
} | {
"id": "C0033559",
"name": "pge",
"pos": [
70,
73
]
} |
in the present study we have shown that the antigens detected in these assays are in fact contained in circulating immune complexes and are recoverable by disassociation with 8 m urea and separation of antibody and antigen by ion exchange chromatography . | NA | {
"id": "C0003313",
"name": "circulating immune complexes",
"pos": [
103,
131
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
202,
210
]
} |
the antibodies thus obtained from immune complexes ( ic ) were assayed by indirect immunofluorescence against a variety of paraffin-embedded tissue sections . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
4,
14
]
} | {
"id": "C0003313",
"name": "immune complexes",
"pos": [
34,
50
]
} |
the present study demonstrates that the antibodies and antigens dissociated from the immune complexes isolated from the ascitic fluids provide useful reagents for immunodiagnosis . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
40,
50
]
} | {
"id": "C0003313",
"name": "immune complexes",
"pos": [
85,
101
]
} |
with a 5-year experience of 79 paired colposcopies , it was concluded that estrogen administration is necessary as a routine precolposcopic procedure in such cases and oral administration of conjugated estrogens at 1.25 mg/day for 14 days is adequate for this purpose . | NA | {
"id": "C0014939",
"name": "estrogen",
"pos": [
75,
83
]
} | {
"id": "C0014938",
"name": "conjugated estrogens",
"pos": [
191,
211
]
} |
thus , the inhibitory activity of a fraction of bovine erythrocyte gangliosides containing long backbone structures of i antigen type was approximately 200 times greater than that of the short chain gangliosides gm3 and gt1b . | NA | {
"id": "C0017082",
"name": "gangliosides",
"pos": [
67,
79
]
} | {
"id": "C0016897",
"name": "gangliosides",
"pos": [
199,
211
]
} |
by immunoelectron microscopy of embedded and sectioned bacteria that had first been treated with specific antisera and ferritin-labeled antirabbit immunoglobulin , the protein adhesin-antibody complex was found to surround the bacteria as a heavy capsule . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
106,
114
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
184,
192
]
} |
a different radioimmunoassay , which uses whole hib cells as antigen , confirmed that strains reactive with mab 6g12 in the colony blot-radioimmunoassay procedure possessed a cell surface-exposed and antibody-accessible antigenic determinant recognized by this mab . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
200,
208
]
} | {
"id": "C0003250",
"name": "mab",
"pos": [
261,
264
]
} |
cfa/i was only found in two serotypes of subgroup o128ac , all of them producing heat-stable enterotoxin except for one which produced both toxins . | NA | {
"id": "C0014372",
"name": "enterotoxin",
"pos": [
93,
104
]
} | {
"id": "C0040549",
"name": "toxins",
"pos": [
140,
146
]
} |
membrane damage by slo is basically analogous to that mediated by previously studied channel formers , namely , the c5b-9 complement complex and staphylococcal alpha-toxin . | NA | {
"id": "C0009545",
"name": "c5b-9",
"pos": [
116,
121
]
} | {
"id": "C0009498",
"name": "complement",
"pos": [
122,
132
]
} |
m. pomifera lectin specifically agglutinated suspensions of s. telaviv and precipitated with its purified lipopolysaccharide and isolated lipid a free o polysaccharide . | NA | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
106,
124
]
} | {
"id": "C0023767",
"name": "lipid a",
"pos": [
138,
145
]
} |
the invasive clinical and benign microscopic characteristics of the lipomas were considered in relation to other adipose tissue tumors . | NA | {
"id": "C0023798",
"name": "benign",
"pos": [
26,
32
]
} | {
"id": "C0206631",
"name": "adipose tissue tumors",
"pos": [
113,
134
]
} |
phenylalanine transfer rna ( trnaphe ) of mammalian tissues contains the hypermodified guanine derivative y ( wye ) adjacent to the 3'-end of the anticodon and two o-methylated bases in the 5 ' portion of the anticodon loop . | NA | {
"id": "C0035711",
"name": "transfer rna",
"pos": [
14,
26
]
} | {
"id": "C0003284",
"name": "anticodon",
"pos": [
209,
218
]
} |
phenylalanyl-trna synthetase from the archaebacterium methanosarcina barkeri activates a number of phenylalanine analogues ( methionine , p-fluorophenylalanine , beta-phenylserine , beta-thien-2-ylalanine , 2-amino-4-methylhex-4-enoic acid and ochratoxin a ) in the absence of trna , as demonstrated by km and kcat of th... | NA | {
"id": "C0031453",
"name": "phenylalanine",
"pos": [
99,
112
]
} | {
"id": "C0030137",
"name": "p-fluorophenylalanine",
"pos": [
138,
159
]
} |
the protein can be purified to apparent homogeneity from retinal homogenates by a combination of gel filtration , lectin , and ion-exchange chromatography . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
4,
11
]
} | {
"id": "C0023206",
"name": "lectin",
"pos": [
114,
120
]
} |
immunological homology between chloroplast ribosomal proteins ( r-proteins ) from a higher plant ( spinacia ) and bacterial r-proteins was examined using antibodies prepared against 35 purified escherichia coli r-proteins . | NA | {
"id": "C0004627",
"name": "bacterial r-proteins",
"pos": [
114,
134
]
} | {
"id": "C0950080",
"name": "escherichia coli r-proteins",
"pos": [
194,
221
]
} |
antisera against five proteins of the small subunit and six proteins of the large subunit of e. coli ribosome ( i.e . anti-s7 , -s9 , -s11 , -s12 , and -s19 ; anti-l1 , -l2 , -l3 , -l6 , -l13 , and -l17 ) gave cross-reactions . | NA | {
"id": "C0599220",
"name": "proteins",
"pos": [
22,
30
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
60,
68
]
} |
the kinetic mechanism of the binding and release of calcium by troponin and by the complexes troponin : tropomyosin , troponin : tropomyosin : actin , and troponin ( tn ) -tropomyosin ( tm ) -actin : myosin subfraction 1 ( sf-1 ) was investigated using troponin labeled on the tn-i subunit with the fluorophore 4- ( n-io... | NA | {
"id": "C0041199",
"name": "troponin",
"pos": [
63,
71
]
} | {
"id": "C0077401",
"name": "tn-i",
"pos": [
277,
281
]
} |
formation of the complex of tn : tm with actin yielded an enhancement of the fluorescence of the labeled tn-i moiety of approximately 30 % . | NA | {
"id": "C0041199",
"name": "complex",
"pos": [
17,
24
]
} | {
"id": "C0077401",
"name": "tn-i",
"pos": [
105,
109
]
} |
the catalyst was prothrombinase , comprising isolated factor xa , factor va , phospholipid vesicles , and calcium ion . | NA | {
"id": "C0015518",
"name": "prothrombinase",
"pos": [
17,
31
]
} | {
"id": "C0015520",
"name": "factor xa",
"pos": [
54,
63
]
} |
the four kallikreins were indistinguishable kinetically with human plasma high-molecular weight kininogen and 15 synthetic substrates , and in correcting the activated partial thromboplastin time of prekallikrein-deficient ( fletcher ) plasma . | NA | {
"id": "C0022478",
"name": "kallikreins",
"pos": [
9,
20
]
} | {
"id": "C0033024",
"name": "prekallikrein",
"pos": [
199,
212
]
} |
in whole plasma , diabetes was associated with significant increases in apolipoprotein ( apo ) -aiv , apo-ai , and apo-b ( mainly in the intestinally derived apo-b240 ) and a marked decrease in apo-e . | NA | {
"id": "C0085201",
"name": "apo-ai",
"pos": [
102,
108
]
} | {
"id": "C0003592",
"name": "a",
"pos": [
194,
195
]
} |
in whole plasma , diabetes was associated with significant increases in apolipoprotein ( apo ) -aiv , apo-ai , and apo-b ( mainly in the intestinally derived apo-b240 ) and a marked decrease in apo-e . | NA | {
"id": "C0003593",
"name": "apo-b",
"pos": [
115,
120
]
} | {
"id": "C0003591",
"name": "apo",
"pos": [
194,
197
]
} |
in whole plasma , diabetes was associated with significant increases in apolipoprotein ( apo ) -aiv , apo-ai , and apo-b ( mainly in the intestinally derived apo-b240 ) and a marked decrease in apo-e . | NA | {
"id": "C0003591",
"name": "apo",
"pos": [
72,
75
]
} | {
"id": "C0003592",
"name": "a",
"pos": [
194,
195
]
} |
in the d less than 1.006 g/ml lipoprotein fraction ( very-low-density lipoproteins ( vldl ] , there were significant increases in apo-b240 , apo-ai , and apo-aiv and decreased levels of apo-e and the c apolipoproteins . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
30,
41
]
} | {
"id": "C0023825",
"name": "very-low-density lipoproteins",
"pos": [
53,
82
]
} |
in the d less than 1.006 g/ml lipoprotein fraction ( very-low-density lipoproteins ( vldl ] , there were significant increases in apo-b240 , apo-ai , and apo-aiv and decreased levels of apo-e and the c apolipoproteins . | NA | {
"id": "C0003595",
"name": "apo-e",
"pos": [
186,
191
]
} | {
"id": "C0003591",
"name": "apolipoproteins",
"pos": [
202,
217
]
} |
the decrease in apo-c was primarily due to lower levels of apo-cii , and the ratio of the lipoprotein lipase inhibitor , apo-ciii , to the lipoprotein lipase activator , apo cii , was significantly increased over that in controls . | NA | {
"id": "C0003594",
"name": "apo-c",
"pos": [
16,
21
]
} | {
"id": "C0052191",
"name": "apo-ciii",
"pos": [
121,
129
]
} |
the decrease in apo-c was primarily due to lower levels of apo-cii , and the ratio of the lipoprotein lipase inhibitor , apo-ciii , to the lipoprotein lipase activator , apo cii , was significantly increased over that in controls . | NA | {
"id": "C0003594",
"name": "apo-c",
"pos": [
16,
21
]
} | {
"id": "C0052190",
"name": "apo cii",
"pos": [
170,
177
]
} |
analysis of media amino acid concentration revealed that glutamine was the main amino acid consumed while alanine was the predominant amino acid produced . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
106,
113
]
} | {
"id": "C0002520",
"name": "amino acid",
"pos": [
134,
144
]
} |
the methylation of either methionine or arginine residues by enzyme i and ii , respectively , lowers the isoelectric point ( pi ) of cytochrome c : 9.23 , 9.33 , and 10.06 for s-methylmethionine- , ng-monomethylarginine-modified , and unmodified cytochrome c , respectively . | NA | {
"id": "C0025646",
"name": "methionine",
"pos": [
26,
36
]
} | {
"id": "C0042889",
"name": "methylmethionine",
"pos": [
178,
194
]
} |
the methylation of either methionine or arginine residues by enzyme i and ii , respectively , lowers the isoelectric point ( pi ) of cytochrome c : 9.23 , 9.33 , and 10.06 for s-methylmethionine- , ng-monomethylarginine-modified , and unmodified cytochrome c , respectively . | NA | {
"id": "C0003765",
"name": "arginine",
"pos": [
40,
48
]
} | {
"id": "C0069477",
"name": "ng-monomethylarginine",
"pos": [
198,
219
]
} |
adenosine ( ado ) , deoxyadenosine ( dado ) , and adenine arabinoside ( araa ) inhibit the phagocytosis of igg-coated erythrocytes and zymosan by resident and thioglycollate-elicited macrophages ( thio-macrophages ) in a dose-dependent and reversible manner . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
0,
9
]
} | {
"id": "C0042646",
"name": "adenine arabinoside",
"pos": [
50,
69
]
} |
homocysteine thiolactonate ( hcy ) potentiates the inhibition by ado and 3cado while erythro-9- ( 2-hydroxy-3-nonyl ) adenine ( ehna ) potentiates the inhibition by ado , dado and araa . | NA | {
"id": "C0001443",
"name": "ado",
"pos": [
65,
68
]
} | {
"id": "C0042646",
"name": "araa",
"pos": [
180,
184
]
} |
depletion of gsh levels to less than 20 % of control by treatment with diethyl maleate , however , did not sensitize the cells to either glucose oxidase or menadione , indicating that the effect of bcnu is related to inhibition of the gsh-gssg redox cycle rather than to the depletion of gsh . | NA | {
"id": "C0061516",
"name": "gssg",
"pos": [
239,
243
]
} | {
"id": "C0017817",
"name": "gsh",
"pos": [
288,
291
]
} |
these data indicate that catalase and the gsh-gssg cycle are active in the defense of hepatocytes against the toxicity of h2o2 . | NA | {
"id": "C0017817",
"name": "gsh",
"pos": [
42,
45
]
} | {
"id": "C0061516",
"name": "gssg",
"pos": [
46,
50
]
} |
we found that the phorbol esters , 12-o-tetradecanoyl phorbol 13-acetate and phorbol 12,13-dibutyrate 1 ) altered the morphology of the tt cells towards that of high-calcitonin-containing cells ; | NA | {
"id": "C0031586",
"name": "phorbol",
"pos": [
18,
25
]
} | {
"id": "C0039654",
"name": "12-o-tetradecanoyl phorbol 13-acetate",
"pos": [
35,
72
]
} |
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