text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
the concentrations of the branched chain keto acids ( bcka ) , branched chain amino acids ( bcaa ) , c peptide , and glucagon were determined in peripheral venous blood . alpha-ketoisocaproic acid , alpha-keto-beta-methyl-n-valeric acid , and alpha-ketoisovaleric acid increased significantly within 36 hours along with ... | NA | {
"id": "C0002521",
"name": "branched chain amino acids",
"pos": [
63,
89
]
} | {
"id": "C0002520",
"name": "amino",
"pos": [
338,
343
]
} |
serum and lipoprotein lipids were determined by standard procedures , apolipoproteins either by laser immunonephelometry or by rocket immunoelectrophoresis . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
10,
21
]
} | {
"id": "C0023779",
"name": "lipids",
"pos": [
22,
28
]
} |
concentration of vldl apolipoprotein b further fell ( -41.6 % ) and that of apolipoprotein e decreased ( -25.9 % ) , resulting in an increased vldl lipid/apolipoprotein mass ratio . | NA | {
"id": "C0003593",
"name": "apolipoprotein b",
"pos": [
22,
38
]
} | {
"id": "C0003591",
"name": "apolipoprotein",
"pos": [
154,
168
]
} |
concentration of vldl apolipoprotein b further fell ( -41.6 % ) and that of apolipoprotein e decreased ( -25.9 % ) , resulting in an increased vldl lipid/apolipoprotein mass ratio . | NA | {
"id": "C0003595",
"name": "apolipoprotein e",
"pos": [
76,
92
]
} | {
"id": "C0003591",
"name": "apolipoprotein",
"pos": [
154,
168
]
} |
a comparison of the binding and response properties of intact cells revealed that the full agonists norepinephrine and epinephrine inhibit cyclic amp accumulation with apparently higher affinity than they exhibit in inhibiting the binding of [ 3h ] yohimbine . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
100,
114
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
119,
130
]
} |
3 ) potent classical dihydrofolate reductase inhibitors were identified that were either not substrates for mouse liver folylpolyglutamate synthetase ( e.g. , 4-amino-4-deoxy-n10-methylpteroyl-l-alpha-aminoadipate ) or were much better substrates than methotrexate for this enzyme ( e.g. , aminopterin ) ; | NA | {
"id": "C0025677",
"name": "methotrexate",
"pos": [
252,
264
]
} | {
"id": "C0002583",
"name": "aminopterin",
"pos": [
290,
301
]
} |
the order of potency for this effect is guanosine 5'-o- ( 3-thiotriphosphate ) greater than 5'-guanylyl-imidodiphosphate = gtp = gdp ; | NA | {
"id": "C0079469",
"name": "guanosine 5",
"pos": [
40,
51
]
} | {
"id": "C0018353",
"name": "gtp",
"pos": [
123,
126
]
} |
the order of potency for this effect is guanosine 5'-o- ( 3-thiotriphosphate ) greater than 5'-guanylyl-imidodiphosphate = gtp = gdp ; | NA | {
"id": "C0018366",
"name": "guanylyl-imidodiphosphate",
"pos": [
95,
120
]
} | {
"id": "C0018353",
"name": "gtp",
"pos": [
123,
126
]
} |
the rank order of potency among opioidbenzomorphans and phencyclidine ( pcp ) analogs for competition for [ 3h ] ( d ) -nanm-binding sites is as follows : ( d ) -nanm = pcp-3-oh greater than ( d ) -cyclazocine greater than n-ethylphenylcyclohexylamine greater than pcp greater than ( l ) -cyclazocine = dextrorphan great... | NA | {
"id": "C0010526",
"name": "cyclazocine",
"pos": [
198,
209
]
} | {
"id": "C0079314",
"name": "ethylketocyclazocine",
"pos": [
337,
357
]
} |
using [ 3h ] inositol-labeled rabbit peritoneal neutrophils , we report that radiolabeled inositol phosphates are generated in response to the chemotactic peptide , formylmethionyl-leucyl-phenylalanine ( fmet-leu-phe ) . | NA | {
"id": "C0021547",
"name": "inositol",
"pos": [
13,
21
]
} | {
"id": "C0021554",
"name": "inositol phosphates",
"pos": [
90,
109
]
} |
the seeds of legumes are particularly rich in lectins , for example , concanavalin a ( con a ) comprises up to 15 % of the protein in the cotyledons of jack bean ( canavalia ensiformis ) seeds . | NA | {
"id": "C0023206",
"name": "lectins",
"pos": [
46,
53
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
123,
130
]
} |
using an rna-dependent rna polymerase ( replicase ) preparation from barley leaves infected with brome mosaic virus ( bmv ) to synthesize the viral subgenomic rna in vitro , we now provide evidence that subgenomic rna arises by internal initiation on the ( - ) -strand of genomic rna . | NA | {
"id": "C0035736",
"name": "viral",
"pos": [
142,
147
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
280,
283
]
} |
the purified mutant proteins are similar to wild type with respect to their visible spectra , 20-70 % as active as wild-type protein in the ccp assay , and their reduction potentials are lowered by as much as 50 mv . | NA | {
"id": "C1564139",
"name": "mutant proteins",
"pos": [
13,
28
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
125,
132
]
} |
we compared cognitive and intellectual performance of patients with pseudoseizures ( pseudoseizure-only group ) , pseudoseizures and epilepsy ( mixed seizure group ) , and generalized epileptic seizures ( generalized seizure group ) . | NA | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
133,
141
]
} | {
"id": "C0036572",
"name": "seizure",
"pos": [
217,
224
]
} |
lean gestational diabetics appear to develop glucose intolerance on the basis of relative insulin deficiency in contrast to obese gestational diabetics who manifest glucose intolerance characterized by insulin resistance , hyperinsulinemia , and decreased insulin binding to red blood cell receptors . | NA | {
"id": "C0021655",
"name": "insulin resistance",
"pos": [
202,
220
]
} | {
"id": "C0020459",
"name": "hyperinsulinemia",
"pos": [
223,
239
]
} |
a change in the initial antibiotic management of suspected septicemia to the use of cloxacillin and an aminoglycoside was also introduced , based on the current knowledge of etiologic agents and their antimicrobial sensitivities . | NA | {
"id": "C0002556",
"name": "aminoglycoside",
"pos": [
103,
117
]
} | {
"id": "C1136254",
"name": "antimicrobial",
"pos": [
201,
214
]
} |
comparison of treatment results showed that triple sulfonamide combined with either phenoxymethyl penicillin , or benzathine and procaine penicillin g given intramuscularly ( im ) was as effective as was ampicillin or amoxicillin . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
204,
214
]
} | {
"id": "C0002645",
"name": "amoxicillin",
"pos": [
218,
229
]
} |
these findings indicate that the pif activity can not be attributed to either dopamine or gaba , both of which are known to inhibit prolactin release , and provide evidence for the presence of a non-dopaminergic and non-gabaergic pif within the hypothalamus . | NA | {
"id": "C0013030",
"name": "dopamine",
"pos": [
78,
86
]
} | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
199,
211
]
} |
the role of cell density and ph on calcium influx was studied in normal and endotoxin-challenged cultured 3t6 fibroblasts . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
0,
3
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
110,
121
]
} |
high molecular weight proteins in extracts of human heart tissue that reacted with an antibody to s. pyogenes also reacted with a monoclonal antibody to ventricular myosin . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
86,
94
]
} | {
"id": "C0003250",
"name": "monoclonal",
"pos": [
130,
140
]
} |
particular emphasis is placed on the definition of terms and the methods of differentiating arteriovenous fistulas , hemangiomas , and arteriovenous malformations . | NA | {
"id": "C0003855",
"name": "arteriovenous fistulas",
"pos": [
92,
114
]
} | {
"id": "C0003857",
"name": "arteriovenous malformations",
"pos": [
135,
162
]
} |
two radioiodinated probes , 125i-cholesteryl oleate ( 125i-co ) , a derivative of a natural constituent of lipoproteins , and 1- ( 2-chlorophenyl ) -1- ( 4 [ 125i ] iodophenyl ) -2,2-dichlorethane ( 125i-ddd ) , an analog of the adrenolytic drug o , p'-ddd ( mitotane ) , were selected to study the role of lipoproteins ... | NA | {
"id": "C0065058",
"name": "a",
"pos": [
5,
6
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
307,
319
]
} |
the permeability of the bbb to proteins was also followed by 125i-albumin transfer from the blood into the brain . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
31,
39
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
66,
73
]
} |
the effects on platelet function and thromboxane a2 synthesis of 40 mg of aspirin daily or 40 mg aspirin plus dipyridamole were measured in 23 patients starting within a week after the onset of cerebral ischemia . | NA | {
"id": "C0004057",
"name": "aspirin",
"pos": [
74,
81
]
} | {
"id": "C0732279",
"name": "aspirin",
"pos": [
97,
104
]
} |
no differences in platelet responses were observed between patients receiving aspirin alone and aspirin plus dipyridamole . | NA | {
"id": "C0004057",
"name": "aspirin",
"pos": [
78,
85
]
} | {
"id": "C0732279",
"name": "aspirin",
"pos": [
96,
103
]
} |
significant decreases of mcbf and the tendency to decrease of the rcbfs in the hypoperfusion focus were noted in the patients with the larger infarcts in comparison with those with the smaller ones . | NA | {
"id": "C0022116",
"name": "hypoperfusion",
"pos": [
79,
92
]
} | {
"id": "C0021308",
"name": "infarcts",
"pos": [
142,
150
]
} |
data previously obtained indicate that , during assembly of the related bacteriophages t7 and t3 , a dna-free procapsid ( capsid i ) is produced and that subsequently capsid i : ( 1 ) binds to a longer than mature ( concatemeric ) dna and then becomes structurally altered to a particle isolated as a capsid ( capsid ii ... | NA | {
"id": "C0000702",
"name": "a dna",
"pos": [
99,
104
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
546,
549
]
} |
data previously obtained indicate that , during assembly of the related bacteriophages t7 and t3 , a dna-free procapsid ( capsid i ) is produced and that subsequently capsid i : ( 1 ) binds to a longer than mature ( concatemeric ) dna and then becomes structurally altered to a particle isolated as a capsid ( capsid ii ... | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
101,
104
]
} | {
"id": "C1257941",
"name": "concatemeric dna",
"pos": [
533,
549
]
} |
it is concluded that protein synthesis is required for the inhibitory activity of vsv , presumably because the active inhibitory complex is a nucleoprotein containing leader rna and either a cellular protein or the viral n protein . | NA | {
"id": "C0028612",
"name": "nucleoprotein",
"pos": [
142,
155
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
223,
230
]
} |
in a retrospective review of 211 female infertility patients receiving ovulation induction agents , the role of sonography in infertility management is defined . | NA | {
"id": "C0021361",
"name": "female infertility",
"pos": [
33,
51
]
} | {
"id": "C0021359",
"name": "infertility",
"pos": [
126,
137
]
} |
during t abn the degree of mechanical impairment appeared less severe ( hypokinesia in 12 and akinesia in two episodes ) than during st ( hypokinesia in one , akinesia in 25 , and dyskinesia in four episodes ) ( p less than 0.001 ) . | NA | {
"id": "C0086439",
"name": "hypokinesia",
"pos": [
72,
83
]
} | {
"id": "C0013384",
"name": "dyskinesia",
"pos": [
180,
190
]
} |
in order to assess the long-term efficacy of diltiazem for the treatment of angina pectoris , eight patients with chronic stable exertional angina who were previously entered into a 4-month randomized , double-blind placebo controlled study , were studied for an additional 12-months . | NA | {
"id": "C0002962",
"name": "angina pectoris",
"pos": [
76,
91
]
} | {
"id": "C0340288",
"name": "chronic stable",
"pos": [
114,
128
]
} |
to evaluate the effects of calcium entry blocking agents on cardiac sympathetic tone during angina pectoris , arterial and coronary sinus ( cs ) norepinephrine ( ne ) and epinephrine ( e ) concentrations and cs blood flow were determined at rest and during pacing-induced angina , both before and after verapamil in nine... | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
145,
159
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
171,
182
]
} |
enalaprilic acid ( mk-422 ) , the biologically active diacid of the converting enzyme inhibitor enalapril , was studied in myocardial ischemia ( mi ) . | NA | {
"id": "C0014027",
"name": "enalaprilic acid",
"pos": [
0,
16
]
} | {
"id": "C0014025",
"name": "enalapril",
"pos": [
96,
105
]
} |
microelectrode studies on isolated rv endocardial infarcted tissues 24 hours after rca occlusions have shown the presence of spontaneous repetitive activity at a rate of 87 +/- 47 bpm , which was overdrive suppressed in dogs with slow vt , and spontaneous activity at a rate of 115.2 +/- 36 bpm ( p less than 0.05 ) whic... | NA | {
"id": "C0078888",
"name": "slow vt",
"pos": [
230,
237
]
} | {
"id": "C0042514",
"name": "vt",
"pos": [
369,
371
]
} |
to investigate the possibility that patients with single-vessel coronary artery disease ( cad ) and recent myocardial infarction ( mi ) can have st segment depression on post infarction treadmill testing due to ischemia , we studied 16 such patients who underwent cardiac catheterization and exercise testing after mi . | NA | {
"id": "C0021308",
"name": "infarction",
"pos": [
118,
128
]
} | {
"id": "C0022116",
"name": "ischemia",
"pos": [
211,
219
]
} |
we conclude that positive post infarction treadmill tests due to exercise-induced ischemia may occur in patients with single-vessel cad and may be associated with continued angina that requires surgical intervention . | NA | {
"id": "C0021308",
"name": "infarction",
"pos": [
31,
41
]
} | {
"id": "C0022116",
"name": "ischemia",
"pos": [
82,
90
]
} |
a total of 63 hearts , consisting of those with chagas ' cardiopathy , normal hearts , and hypertrophied hearts , were studied . | NA | {
"id": "C0018799",
"name": "cardiopathy",
"pos": [
57,
68
]
} | {
"id": "C0018800",
"name": "hypertrophied hearts",
"pos": [
91,
111
]
} |
no significant changes of plasma epinephrine concentrations were recorded , whereas plasma norepinephrine concentrations were increased by 24 % at rest during light intoxication and by 30 to 38 % during heavy intoxication . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
33,
44
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
91,
105
]
} |
the mechanisms whereby circulating epinephrine and norepinephrine modulate norepinephrine release and vascular tone are beginning to be understood and likely involve presynaptic , postsynaptic and nonsynaptic vascular receptors . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
35,
46
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
75,
89
]
} |
biopterin and neopterin concentrations were measured by reverse-phase high pressure liquid chromatography in milks of man , cow , rabbit , cat , and rat and in commercial formulas widely used in north america . | NA | {
"id": "C0005562",
"name": "biopterin",
"pos": [
0,
9
]
} | {
"id": "C0068527",
"name": "neopterin",
"pos": [
14,
23
]
} |
in contrast the increased area under the plasma zinc curve up to 5 hours after the turkey meal , 28 +/- 9 mumol/l ( mean +/- sd ) was significantly less than that for zinc chloride alone , 47 +/- 15 mumol/l , p less than 0.005 . | NA | {
"id": "C0043481",
"name": "zinc",
"pos": [
48,
52
]
} | {
"id": "C0078774",
"name": "zinc",
"pos": [
167,
171
]
} |
two of three patients completing elemental balance studies were in negative nitrogen , potassium , and phosphorus balance , suggesting an essential nutrient deficiency . | NA | {
"id": "C0013879",
"name": "elemental",
"pos": [
33,
42
]
} | {
"id": "C0028158",
"name": "nitrogen",
"pos": [
76,
84
]
} |
two of three patients completing elemental balance studies were in negative nitrogen , potassium , and phosphorus balance , suggesting an essential nutrient deficiency . | NA | {
"id": "C0013879",
"name": "elemental",
"pos": [
33,
42
]
} | {
"id": "C0031705",
"name": "phosphorus",
"pos": [
103,
113
]
} |
their results indicate that microwave-thawed plasma contains precipitated denatured protein ( mainly albumin and fibrinogen ) and that there is a significant reduction of coagulation factors ix , x , xi , and fibrinogen compared with fresh plasma . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
84,
91
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
101,
108
]
} |
all three had acquired immune deficiency syndrome as demonstrated by demography , sexual history , cachexia , opportunistic infections by cytomegalovirus , pneumocystis carinii , atypical mycobacterium , candida , and/or evidence of immune deficiency , such as skin test anergy , lymphopenia , inversion of t-helper/t-su... | NA | {
"id": "C0021051",
"name": "immune",
"pos": [
23,
29
]
} | {
"id": "C0024312",
"name": "diminished lymphocyte",
"pos": [
341,
362
]
} |
30 % of the subjects with ocular hypertension and 73 % of the patients with glaucoma had rim areas less than 1.09 mm2 . | NA | {
"id": "C0028840",
"name": "ocular hypertension",
"pos": [
26,
45
]
} | {
"id": "C0017601",
"name": "glaucoma",
"pos": [
76,
84
]
} |
lacrimal obstruction was also associated with canaliculitis , punctal agenesis , trauma , congenital fistula , dacryocystitis , craniofacial defects , and functional eyelid abnormalities . | NA | {
"id": "C0423172",
"name": "canaliculitis",
"pos": [
46,
59
]
} | {
"id": "C0010930",
"name": "dacryocystitis",
"pos": [
111,
125
]
} |
the methods of pentobarbital administration influenced plasma pentobarbital as well as epinephrine and norepinephrine levels , temperature , heart rate , and blood pressure . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
87,
98
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
103,
117
]
} |
male rats were treated with daily subcutaneous injections ( 3 micrograms/kg ) of cholecystokinin octapeptide ( cck-op ) , a synthetic cck analogue , for 2 , 4 , 7 , and 14 days , while control rats were injected with saline over the same intervals . | NA | {
"id": "C0037167",
"name": "cholecystokinin octapeptide",
"pos": [
81,
108
]
} | {
"id": "C2917328",
"name": "cck analogue",
"pos": [
134,
146
]
} |
crypts with abnormal mucin production ( sialomucin dominant ) had significantly higher labeling indexes when compared with those of control animals ( p less than 0.005 ) . | NA | {
"id": "C0026682",
"name": "mucin",
"pos": [
21,
26
]
} | {
"id": "C0074477",
"name": "sialomucin",
"pos": [
40,
50
]
} |
during the nitroprusside infusion , bolus doses of epinephrine and snp as well as phlebotomy were used to challenge the controller . | NA | {
"id": "C0028193",
"name": "nitroprusside",
"pos": [
11,
24
]
} | {
"id": "C0037533",
"name": "snp",
"pos": [
67,
70
]
} |
after 1 hr of snp infusion , the rate of snp infusion required to maintain a 30 mm hg reduction in pressure averaged 112 ml/hr with a standard deviation of 108 ml/hr . | NA | {
"id": "C0028193",
"name": "snp",
"pos": [
14,
17
]
} | {
"id": "C0037533",
"name": "snp",
"pos": [
41,
44
]
} |
twenty-seven patients ( 49 % ) had carcinoid tumors , 16 ( 29 % ) had adenocarcinomas , and 12 ( 22 % ) had leiomyosarcomas . | NA | {
"id": "C0007095",
"name": "carcinoid tumors",
"pos": [
35,
51
]
} | {
"id": "C0001418",
"name": "adenocarcinomas",
"pos": [
70,
85
]
} |
although 27 per cent of carcinoid patients were asymptomatic , 40 per cent exhibited the carcinoid syndrome . | NA | {
"id": "C0007095",
"name": "carcinoid",
"pos": [
24,
33
]
} | {
"id": "C0024586",
"name": "carcinoid syndrome",
"pos": [
89,
107
]
} |
peripheral neuropathy was found in 27 patients ( 52 % ) , with a sensory polyneuropathy the commonest form ( in 23 patients ) , although mononeuritis multiplex and radiculopathy were also seen . | NA | {
"id": "C0031117",
"name": "peripheral neuropathy",
"pos": [
0,
21
]
} | {
"id": "C0700594",
"name": "radiculopathy",
"pos": [
164,
177
]
} |
however , 20 patients had abnormal serologic profiles specific for epstein-barr virus shown by significantly elevated titers of antibodies to the viral capsid antigen or early antigen , or by a deficiency of late-appearing antibodies . | NA | {
"id": "C0003342",
"name": "viral",
"pos": [
146,
151
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
176,
183
]
} |
unliganded crp is relatively resistant to attack by a variety of proteases ( trypsin , subtilisin , staphylococcus aureus v8 protease , clostripain , chymotrypsin ) which cleave camp-crp , producing n-terminal cores which have lost dna binding activity . | NA | {
"id": "C0030940",
"name": "proteases",
"pos": [
65,
74
]
} | {
"id": "C0030946",
"name": "protease",
"pos": [
125,
133
]
} |
pyruvate and phenazine methosulfate were found to stimulate incorporation of labeled hypoxanthine into the purine nucleotide fraction in general , and into the nucleotide triphosphates in particular . | NA | {
"id": "C0034137",
"name": "purine",
"pos": [
107,
113
]
} | {
"id": "C0028630",
"name": "nucleotide",
"pos": [
160,
170
]
} |
the stimulatory effect of pyruvate on protein synthesis and on the cellular level of atp was also observed in respiration-inhibited 3t6 cells and in human fibroblasts , but not in human fibroblasts deficient in the salvage enzyme , hypoxanthine-guanine-phosphoribosyltransferase . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
136,
141
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
186,
197
]
} |
studies on its substrate specificity showed that the purified enzyme degrades glucagon , insulin , insulin b chain , and insulin a chain , but it does not degrade proinsulin , acth , or denatured hemoglobin . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
89,
96
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
163,
173
]
} |
it was found to be an acidic protein , as evidenced by the amino acid analysis , enriched with glutamate , aspartate , alanine and glycine . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
59,
69
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
119,
126
]
} |
it was found to be an acidic protein , as evidenced by the amino acid analysis , enriched with glutamate , aspartate , alanine and glycine . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
59,
69
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
131,
138
]
} |
the difference between the spectra of the molar ellipticity of the above sequential oligosaccharides was taken to be the cd spectrum of the corresponding additional disaccharide unit ( s ) . | NA | {
"id": "C0028959",
"name": "oligosaccharides",
"pos": [
84,
100
]
} | {
"id": "C0012611",
"name": "disaccharide",
"pos": [
165,
177
]
} |
the enzyme could be phosphorylated by camp-dependent protein kinase , phosphorylase kinase , and the camp-independent protein kinases , pc0.7 and fa/gsk-3 . | NA | {
"id": "C0031713",
"name": "phosphorylase kinase",
"pos": [
70,
90
]
} | {
"id": "C0033640",
"name": "protein kinases",
"pos": [
118,
133
]
} |
while the prior application of triamcinolone acetonide to skin does not strongly influence patch test reactions , the presence of triamcinolone in the materials used for patch testing has a profound effect . | NA | {
"id": "C0040866",
"name": "triamcinolone acetonide",
"pos": [
31,
54
]
} | {
"id": "C0040864",
"name": "triamcinolone",
"pos": [
130,
143
]
} |
the assembly of membrane attack complex ( mac ) of complement implies activation of complement to the attachment of c9 and the presence of mac on tissue suggests a possible pathogenic role for complement in disease since mac is able to damage membranes . | NA | {
"id": "C0009498",
"name": "complement",
"pos": [
51,
61
]
} | {
"id": "C0009545",
"name": "mac",
"pos": [
221,
224
]
} |
in an 11-year study of experimental insulin-deficient diabetes ( iddm ) induced in rhesus monkeys by streptozotocin or total pancreatectomy , the authors have found that pathophysiologic changes occur in eye and kidney , which closely resemble the early stages of human insulin deficient diabetes mellitus ( iddm ) . | NA | {
"id": "C0011853",
"name": "experimental",
"pos": [
23,
35
]
} | {
"id": "C0011849",
"name": "diabetes mellitus",
"pos": [
288,
305
]
} |
in an 11-year study of experimental insulin-deficient diabetes ( iddm ) induced in rhesus monkeys by streptozotocin or total pancreatectomy , the authors have found that pathophysiologic changes occur in eye and kidney , which closely resemble the early stages of human insulin deficient diabetes mellitus ( iddm ) . | NA | {
"id": "C0795635",
"name": "human insulin",
"pos": [
264,
277
]
} | {
"id": "C0021641",
"name": "iddm",
"pos": [
308,
312
]
} |
a transient elevation above 60 iu/1 was recorded in 111 ( 84.1 % ) of 132 attacks associated with gallstones , but in only 12 ( 14.5 % ) of 83 attacks without stones , and was unrelated to the severity of the attack . | NA | {
"id": "C0008350",
"name": "gallstones",
"pos": [
98,
108
]
} | {
"id": "C0006736",
"name": "stones",
"pos": [
159,
165
]
} |
risk for suicide was significant for patients of both sexes with acute schizophrenia , schizophrenia , affective disorders , and alcohol and other drug abuse , for men with neuroses , and for women with depressive neuroses . | NA | {
"id": "C0525045",
"name": "affective disorders",
"pos": [
103,
122
]
} | {
"id": "C0011581",
"name": "depressive neuroses",
"pos": [
203,
222
]
} |
it is postulated that pathologic narrowing of the spinal canal in spinal stenosis leads to nerve root compression and ischemia with resultant dysfunction primarily affecting large diameter myelinated fibers and that decompression procedure may adequately relieve the underlying pathologic processes . | NA | {
"id": "C0022116",
"name": "ischemia",
"pos": [
118,
126
]
} | {
"id": "C0030660",
"name": "pathologic",
"pos": [
278,
288
]
} |
a method , devised in the authors ' laboratories , for the determination of c3b receptors on normal and patient neutrophils using c3b-coated fluorescent microspheres , was applied to the quantitation of c3b receptors on the neutrophils of several patients suffering from burns and trauma and a patient with pancreatitis ... | NA | {
"id": "C0006434",
"name": "burns",
"pos": [
271,
276
]
} | {
"id": "C0043251",
"name": "trauma",
"pos": [
281,
287
]
} |
one hundred eighty-seven patients treated for established intra-abdominal infection in five medical centers were studied using the surgical infection stratification system . | NA | {
"id": "C1112209",
"name": "intra-abdominal",
"pos": [
58,
73
]
} | {
"id": "C0009450",
"name": "infection",
"pos": [
140,
149
]
} |
susceptibility studies showed a high degree of resistance to the penicillin alone that was significantly lowered by the addition of sulbactam . | NA | {
"id": "C0030842",
"name": "penicillin",
"pos": [
65,
75
]
} | {
"id": "C0038665",
"name": "sulbactam",
"pos": [
132,
141
]
} |
the reasons are multiple , and include acquired immunologic deficiencies that are seen in malnutrition , sepsis , trauma , and burns . | NA | {
"id": "C0043251",
"name": "trauma",
"pos": [
114,
120
]
} | {
"id": "C0006434",
"name": "burns",
"pos": [
127,
132
]
} |
enzyme-linked immunosorbent assay ( elisa ) titers to a variety of gram-negative bacterial whole cell and lps antigens demonstrated that this antibody may react with the o antigen portion of 0111 : b4 lps . | NA | {
"id": "C0069180",
"name": "o antigen",
"pos": [
170,
179
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
201,
204
]
} |
protection occurred in an antibody dose-dependent manner , and as little as 0.01 mg of 5b10 mab enhanced survival . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
26,
34
]
} | {
"id": "C0003250",
"name": "mab",
"pos": [
92,
95
]
} |
we concluded that ip pretreatment with a single mab would protect against lethal sepsis or endotoxemia in this animal model and that anti-lps specificity was a sufficient condition for an antibody to protect during bacteremia , confirming the importance of lps in the pathogenesis of gram-negative bacterial sepsis . | NA | {
"id": "C0376618",
"name": "endotoxemia",
"pos": [
91,
102
]
} | {
"id": "C0004610",
"name": "bacteremia",
"pos": [
215,
225
]
} |
glucose , glutamine , and alanine exchange across the gastrointestinal ( gi ) tract , liver , and kidneys was determined in 25 awake dogs that were catheterized on a long-term basis during a control period and after dexamethasone sodium phosphate treatment ( 0.44 mg/kg/day ) for two ( dexamethasone 2 ) and nine ( dexam... | NA | {
"id": "C0113286",
"name": "dexamethasone sodium phosphate",
"pos": [
216,
246
]
} | {
"id": "C0011777",
"name": "dexamethasone",
"pos": [
315,
328
]
} |
in sds gel electrophoresis , the vldl shows the presence of a major band corresponding to low density lipoprotein ( ldl ) apo b ( apo b-100 ) and a minor band with the appropriate mobility of the lymph chylomicron apo b ( apo b-48 ) . | NA | {
"id": "C0003593",
"name": "apo b",
"pos": [
122,
127
]
} | {
"id": "C0205666",
"name": "apo b-100",
"pos": [
130,
139
]
} |
in sds gel electrophoresis , the vldl shows the presence of a major band corresponding to low density lipoprotein ( ldl ) apo b ( apo b-100 ) and a minor band with the appropriate mobility of the lymph chylomicron apo b ( apo b-48 ) . | NA | {
"id": "C0003593",
"name": "apo b",
"pos": [
122,
127
]
} | {
"id": "C0103839",
"name": "apo b-48",
"pos": [
222,
230
]
} |
the reactivity of monoclonal antibodies directed against opportunely selected human apo b suggests that the protein with the lower molecular weight corresponds to apo b-48 . | NA | {
"id": "C0003593",
"name": "apo b",
"pos": [
84,
89
]
} | {
"id": "C0103839",
"name": "apo b-48",
"pos": [
163,
171
]
} |
four different spin-labeled stearic acids , 5- ( n-oxyl-4',4'-dimethyloxazolidine ) -stearic acid ( 5sls ) , its methyl ester ( 5slsm ) , 12- ( n-oxyl-4',4'-dimethyloxazolidine ) -stearic acid ( 12sls ) and its methyl ester ( 12slsm ) , were used for the estimation of membrane fluidity . | NA | {
"id": "C0038230",
"name": "stearic acids",
"pos": [
28,
41
]
} | {
"id": "C0038229",
"name": "stearic acid",
"pos": [
180,
192
]
} |
the dihydropyridine ( dhp ) ca2+ channel blocking drugs nicardipine , nitrendipine , nimodipine , felodipine , nifedipine and nisoldipine were examined for activity in inhibiting specific ( - ) - [ 3h ] qnb and [ 3h ] wb4101 binding to the muscarinic and alpha-adrenergic receptors , respectively , of rat brain . | NA | {
"id": "C0012315",
"name": "dihydropyridine",
"pos": [
4,
19
]
} | {
"id": "C0028127",
"name": "nitrendipine",
"pos": [
70,
82
]
} |
the dihydropyridine ( dhp ) ca2+ channel blocking drugs nicardipine , nitrendipine , nimodipine , felodipine , nifedipine and nisoldipine were examined for activity in inhibiting specific ( - ) - [ 3h ] qnb and [ 3h ] wb4101 binding to the muscarinic and alpha-adrenergic receptors , respectively , of rat brain . | NA | {
"id": "C0012315",
"name": "dihydropyridine",
"pos": [
4,
19
]
} | {
"id": "C0028094",
"name": "nimodipine",
"pos": [
85,
95
]
} |
the dihydropyridine ( dhp ) ca2+ channel blocking drugs nicardipine , nitrendipine , nimodipine , felodipine , nifedipine and nisoldipine were examined for activity in inhibiting specific ( - ) - [ 3h ] qnb and [ 3h ] wb4101 binding to the muscarinic and alpha-adrenergic receptors , respectively , of rat brain . | NA | {
"id": "C0012315",
"name": "dihydropyridine",
"pos": [
4,
19
]
} | {
"id": "C0015772",
"name": "felodipine",
"pos": [
98,
108
]
} |
the dihydropyridine ( dhp ) ca2+ channel blocking drugs nicardipine , nitrendipine , nimodipine , felodipine , nifedipine and nisoldipine were examined for activity in inhibiting specific ( - ) - [ 3h ] qnb and [ 3h ] wb4101 binding to the muscarinic and alpha-adrenergic receptors , respectively , of rat brain . | NA | {
"id": "C0012315",
"name": "dihydropyridine",
"pos": [
4,
19
]
} | {
"id": "C0028066",
"name": "nifedipine",
"pos": [
111,
121
]
} |
this inhibitory effect of nicardipine was not mediated via interaction with the high-affinity dhp binding site assumed to be associated with a ca2+ channel . | NA | {
"id": "C0028005",
"name": "nicardipine",
"pos": [
26,
37
]
} | {
"id": "C0012315",
"name": "dhp",
"pos": [
94,
97
]
} |
( + ) -nicardipine inhibited the binding of [ 3h ] nitrendipine to this dhp binding site of brain , with a k1 of 9.01 x 10 ( -11 ) m , and was 10 times more potent than the ( - ) -isomer . | NA | {
"id": "C0028005",
"name": "nicardipine",
"pos": [
7,
18
]
} | {
"id": "C0012315",
"name": "dhp",
"pos": [
72,
75
]
} |
( + ) -nicardipine inhibited the binding of [ 3h ] nitrendipine to this dhp binding site of brain , with a k1 of 9.01 x 10 ( -11 ) m , and was 10 times more potent than the ( - ) -isomer . | NA | {
"id": "C0028127",
"name": "nitrendipine",
"pos": [
51,
63
]
} | {
"id": "C0012315",
"name": "dhp",
"pos": [
72,
75
]
} |
thus , the muscarinic receptor was 4200 times less sensitive to ( + ) -nicardipine than was this dhp binding site . | NA | {
"id": "C0028005",
"name": "nicardipine",
"pos": [
71,
82
]
} | {
"id": "C0012315",
"name": "dhp",
"pos": [
97,
100
]
} |
only 4 individuals ( 5 % ) developed clear evidence of a connective tissue disease , and in all cases , the diagnosis was the crest ( calcinosis , raynaud 's phenomenon , esophageal dysmotility , sclerodactyly , telangiectasias ) syndrome variant of systemic sclerosis . | NA | {
"id": "C0009782",
"name": "of",
"pos": [
52,
54
]
} | {
"id": "C0036421",
"name": "systemic sclerosis",
"pos": [
250,
268
]
} |
retrospective and prospective studies of high resolution cross sectional echocardiograms were undertaken in order to establish an ultrasonic method for the non-invasive estimation of degeneration and fibrosis of the endomyocardium in cases of cardiomyopathy . | NA | {
"id": "C0553980",
"name": "fibrosis",
"pos": [
200,
208
]
} | {
"id": "C0878544",
"name": "cardiomyopathy",
"pos": [
243,
257
]
} |
we examined the ability of primary human tumour cells to secrete diffusible factors capable of stimulating anchorage independent growth of normal rat kidney fibroblast ( nrk ) cells . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
157,
167
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
176,
181
]
} |
we conclude that ( i ) trr expression on nhl cells is not obligatory related with histological class or malignancy grade of the tumour , and that ( ii ) hnk-1+ cells are not universally present in areas of malignant cells , in particular in follicular lymphoma and in nhl of high grade malignancy . | NA | {
"id": "C0024301",
"name": "follicular lymphoma",
"pos": [
241,
260
]
} | {
"id": "C0024305",
"name": "nhl",
"pos": [
268,
271
]
} |
all three lines exhibited both epithelial and fibroblastic elements after 10-14 passages in vitro , demonstrating that the dimorphic histology of these tumours could be derived from a single aberrant cell . | NA | {
"id": "C0016030",
"name": "fibroblastic",
"pos": [
46,
58
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
200,
204
]
} |
pregnancy continued into the third trimester in five cases complicated solely by gastroschisis and two babies have survived the neonatal period following surgical correction . | NA | {
"id": "C0032961",
"name": "pregnancy",
"pos": [
0,
9
]
} | {
"id": "C0032981",
"name": "third trimester",
"pos": [
29,
44
]
} |
the levels of hpl , pp5 and e3 just before delivery were significantly correlated with the total birthweight , a correlation with placental weight being evident only for hpl and pp5 . | NA | {
"id": "C0005612",
"name": "birthweight",
"pos": [
97,
108
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
140,
146
]
} |
the adamantane derivative amantadine causes fluidization of the human erythrocyte membrane and inhibits vesicle release . | NA | {
"id": "C0001392",
"name": "adamantane",
"pos": [
4,
14
]
} | {
"id": "C0002403",
"name": "amantadine",
"pos": [
26,
36
]
} |
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