text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
these proteins remained undetected in earlier studies on dna-binding proteins from calf thymus because they are extremely sensitive to proteolytic breakdown occurring during purification . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
6,
14
]
} | {
"id": "C0012940",
"name": "dna-binding proteins",
"pos": [
57,
77
]
} |
the ub thiol ester forms of two of the e2s were found to catalyze ub transfer to cytochrome c . | NA | {
"id": "C0041538",
"name": "ub",
"pos": [
4,
6
]
} | {
"id": "C0949722",
"name": "ub",
"pos": [
66,
68
]
} |
however , the potency series of gtp analogues to alter norepinephrine binding was gtp gamma s greater than gppnhp greater than or equal to gtp greater than or equal to gdp greater than or equal to gppchp greater than gmp ( where gtp gamma s represents guanosine 5'-o- ( thiotriphosphate ) and gppchp represents guanyl-5'... | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
32,
35
]
} | {
"id": "C0079469",
"name": "gtp gamma s",
"pos": [
229,
240
]
} |
we studied the effect of ca2+ depletion on the hydrolysis of the phospholipids of polymixin b-killed e. coli by 1 ) added pig pancreas phospholipase a2 in e. coli s17 ( a phospholipase a-lacking mutant ) and 2 ) endogenous ca2+-dependent phospholipase a1 in the parent strain e. coli s15 . | NA | {
"id": "C0031667",
"name": "phospholipase a2",
"pos": [
135,
151
]
} | {
"id": "C0031672",
"name": "phospholipase",
"pos": [
238,
251
]
} |
we studied the effect of ca2+ depletion on the hydrolysis of the phospholipids of polymixin b-killed e. coli by 1 ) added pig pancreas phospholipase a2 in e. coli s17 ( a phospholipase a-lacking mutant ) and 2 ) endogenous ca2+-dependent phospholipase a1 in the parent strain e. coli s15 . | NA | {
"id": "C0031672",
"name": "phospholipase",
"pos": [
135,
148
]
} | {
"id": "C0031666",
"name": "phospholipase a1",
"pos": [
238,
254
]
} |
the bacterial ca2+ content was repleted and the sensitivity of the bacterial phospholipids to hydrolysis by both exogenous phospholipase a2 ( e. coli s17 ) and endogenous phospholipase a ( e. coli s15 ) was restored by adding ca2+ back to the suspensions . | NA | {
"id": "C0031667",
"name": "phospholipase a2",
"pos": [
123,
139
]
} | {
"id": "C0031672",
"name": "phospholipase a",
"pos": [
171,
186
]
} |
of the proteases tested , only pronase and chymotrypsin cleave and inactivate the enzyme inserted into phospholipid vesicles ( enzyme-phospholipid complex ) . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
82,
88
]
} | {
"id": "C0026741",
"name": "enzyme",
"pos": [
127,
133
]
} |
the tumor-promoting phorbol ester , phorbol 12-myristate 13-acetate stimulated the protein kinase c-catalyzed phosphorylation of hmg-coa reductase . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
20,
33
]
} | {
"id": "C0039654",
"name": "phorbol",
"pos": [
36,
43
]
} |
the bacteriophage t4 gene 61 protein is required , together with the gene 41 protein and single-stranded dna , for the synthesis of the pentaribonucleotides that are used as primers for the start of each new okazaki dna fragment during t4 dna replication . | NA | {
"id": "C0012935",
"name": "single-stranded dna",
"pos": [
89,
108
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
239,
242
]
} |
the cytochrome p1-450-dependent activity , aryl hydrocarbon hydroxylase , and cytochrome p1-450 messenger rna levels were studied in wild-type hepa1c1c7 cells and in aryl hydrocarbon hydroxylase-deficient mutants derived from this line . | NA | {
"id": "C0059735",
"name": "cytochrome p1-450",
"pos": [
4,
21
]
} | {
"id": "C0003927",
"name": "aryl hydrocarbon hydroxylase",
"pos": [
166,
194
]
} |
plasma fibronectin is covalently incorporated into alpha-chains of fibrin gels in the presence of factor xiii activated by thrombin ( fxiiiat ) but not by factor xiii activated by the snake venom enzyme batroxobin ( fxiiiab ) . | NA | {
"id": "C0015533",
"name": "factor xiii activated",
"pos": [
98,
119
]
} | {
"id": "C0015528",
"name": "factor",
"pos": [
155,
161
]
} |
a 20-fold stimulation of the conversion of pregnenolone to 17 alpha-hydroxypregnenolone was observed in postmitochondrial supernatant fractions from cells treated with acth as compared to controls . | NA | {
"id": "C0373704",
"name": "pregnenolone",
"pos": [
43,
55
]
} | {
"id": "C0376260",
"name": "17 alpha-hydroxypregnenolone",
"pos": [
59,
87
]
} |
ngf-receptors in these membrane preparations are also uniformly highly sensitive to tryptic proteolysis , and 125i-ngf bound to ngf-receptor in these membranes is rapidly dissociated in the presence of a high concentration of unlabeled ngf . | NA | {
"id": "C0132173",
"name": "ngf-receptors",
"pos": [
0,
13
]
} | {
"id": "C0254837",
"name": "ngf-receptor",
"pos": [
128,
140
]
} |
with fibroblasts from nine patients , a decreased amount of labeled type iii procollagen was recovered in the medium after the cells were incubated with radioactive amino acids for 24 h . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
5,
16
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
127,
132
]
} |
idiopathic osteolysis is characterised by a spontaneous onset without previous causative factors , followed by rapid destruction and resorption of the involved bones . | NA | {
"id": "C0221204",
"name": "osteolysis",
"pos": [
11,
21
]
} | {
"id": "C0005974",
"name": "resorption",
"pos": [
133,
143
]
} |
in subcellular fractions of rsv-infected chicken embryo fibroblasts ( rsv-cefs ) and field vole cells probed with tbr serum , the majority of the pp60v-src was associated with the plasma membrane-enriched p100 fraction . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
56,
67
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
96,
101
]
} |
when grown in the presence of serum with added insulin , chinese hamster embryonic fibroblasts ( chef/18 ) cells can be induced to become preadipocytes that are committed to the adipocyte pathway of terminal differentiation ( sager , r. , and p . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
83,
94
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
107,
112
]
} |
low density rabbit costal chondrocyte cultures grown in the absence of fgf gave rise at confluency to a heterogeneous cell population composed of fibroblastic cells and poorly differentiated chondrocytes . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
118,
122
]
} | {
"id": "C0016030",
"name": "fibroblastic cells",
"pos": [
146,
164
]
} |
low density rabbit costal chondrocyte cultures grown in the absence of fgf gave rise at confluency to a heterogeneous cell population composed of fibroblastic cells and poorly differentiated chondrocytes . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
118,
122
]
} | {
"id": "C0225369",
"name": "chondrocytes",
"pos": [
191,
203
]
} |
we examined the effect of an extracellular matrix ( ecm ) , produced by either bovine corneal endothelial ( bce ) cells or mouse pf hr-9 teratocarcinoma cells , on the ability of rabbit costal chondrocytes to re-express their phenotype once confluent . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
114,
119
]
} | {
"id": "C0225369",
"name": "chondrocytes",
"pos": [
193,
205
]
} |
rabbit chondrocytes seeded at low densities and grown on plastic tissue culture dishes produced a heterogeneous cell population composed of both overtly differentiated and poorly differentiated chondrocytes , as well as fibroblastic cells . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
112,
116
]
} | {
"id": "C0225369",
"name": "chondrocytes",
"pos": [
194,
206
]
} |
rabbit chondrocytes seeded at low densities and grown on plastic tissue culture dishes produced a heterogeneous cell population composed of both overtly differentiated and poorly differentiated chondrocytes , as well as fibroblastic cells . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
112,
116
]
} | {
"id": "C0016030",
"name": "fibroblastic cells",
"pos": [
220,
238
]
} |
native intermediate filament ( if ) preparations from the baby hamster kidney fibroblastic cell line ( bhk-21 ) contain a number of minor polypeptides in addition to the if structural subunit proteins desmin , a 54,000-mol-wt protein , and vimentin , a 55,000-mol-wt protein . | NA | {
"id": "C0021769",
"name": "if",
"pos": [
31,
33
]
} | {
"id": "C0042666",
"name": "vimentin",
"pos": [
240,
248
]
} |
production of gp140 , a major component of the extracellular matrix of cultured fibroblasts , is markedly decreased in sv40 transformed cells as compared with normal cells ( carter , w . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
80,
91
]
} | {
"id": "C0007634",
"name": "normal cells",
"pos": [
159,
171
]
} |
four of these lines were isolated after selection for partial resistance to the purine ( adenine ) analog 2 ' 6'diaminopurine and five were isolated from non-selected control dishes . | NA | {
"id": "C0034140",
"name": "purine",
"pos": [
80,
86
]
} | {
"id": "C0001407",
"name": "adenine",
"pos": [
89,
96
]
} |
four temperature-sensitive mutants of rat 3y1 fibroblasts belonging to separate complementation groups ( 3y1tsd123 , 3y1tsf121 , 3y1tsg125 , and 3y1tsh203 ) are arrested mainly with a 2c dna content , when cells proliferating at 33.8 degrees c are shifted up to 39.8 degrees c ( ohno et al. , 1984 ) . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
46,
57
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
206,
211
]
} |
unlike human fibroblasts , the h4 cells did not require serum to exhibit the depression of system a . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
13,
24
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
34,
39
]
} |
it displays a similar activity on bovine vascular smooth muscle cells , corneal endothelial cells , granulosa and adrenal cortex cells , and rabbit costal chondrocytes . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
64,
69
]
} | {
"id": "C0225369",
"name": "chondrocytes",
"pos": [
155,
167
]
} |
an increase in collagen synthesis by hepatic parenchymal cells ( hepatocytes ) was observed during 8 days in primary culture by the quantification of total [ 3h ] hydroxyproline as a marker of total collagen synthesis and the ratio of [ 3h ] hydroxyproline in the high-molecular-weight fraction to total [ 3h ] hydroxypr... | NA | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
163,
177
]
} | {
"id": "C0033382",
"name": "proline",
"pos": [
404,
411
]
} |
cell hybrids were formed between human diploid fibroblasts ( hdf ) and carcinogen-transformed hdf to determine the relationship among : ( 1 ) finite proliferative lifespan , which we define as an age-related failure of a population to achieve one population doubling in 4 weeks ; | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
0,
4
]
} | {
"id": "C0016030",
"name": "hdf",
"pos": [
94,
97
]
} |
fusion of fpl+ , q+ , s+ hdf x fpl- , q- carcinogen-transformed hdf produced hybrid clones that were fpl+ , q- , and s- , where the s- phenotype means that individual cells continued to synthesize dna in cultures that had reached the end of their lifespan by our definition . | NA | {
"id": "C0016030",
"name": "hdf",
"pos": [
25,
28
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
167,
172
]
} |
the cells were demonstrated not to be fibroblasts and are described in terms of their appearance under the light and electron microscopes . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
4,
9
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
38,
49
]
} |
autopsy specimens of lung tissues from 15 patients that contracted legionellosis during the 1976 philadelphia outbreak of legionnaires disease were examined for the presence of legionella organisms and soluble antigens by indirect fluorescent-antibody ( ifa ) testing and by an enzyme-linked immunosorbent assay ( elisa ... | NA | {
"id": "C0023240",
"name": "legionellosis",
"pos": [
67,
80
]
} | {
"id": "C0023241",
"name": "legionnaires disease",
"pos": [
122,
142
]
} |
in most instances the total number of identified cells was significantly less than the total number of recovered blood mononuclear cells , which suggests the existence in blood of a null cell population . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
18,
21
]
} | {
"id": "C1321301",
"name": "blood mononuclear cells",
"pos": [
113,
136
]
} |
the enzymes studied most extensively in this field are terminal deoxynucleotidyl transferase , adenosine deaminase , 5'-nucleotidase , purine nucleoside phosphorylase , and acid phosphatase , esterase , hexosaminidase isoenzymes . | NA | {
"id": "C0014442",
"name": "enzymes",
"pos": [
4,
11
]
} | {
"id": "C0022173",
"name": "isoenzymes",
"pos": [
218,
228
]
} |
immunoreactive plasminogen activators were studied in tissue sections using a peroxidase method and monospecific antibodies to tissue plasminogen activator produced by a melanoma . | NA | {
"id": "C0032144",
"name": "plasminogen activators",
"pos": [
15,
37
]
} | {
"id": "C0032143",
"name": "tissue plasminogen activator",
"pos": [
127,
155
]
} |
on the basis of characteristic antigenic profiles of tumours , it has been possible to distinguish between gliomas , meningiomas , schwannomas , medulloblastomas , neuroblastomas , choroid plexus tumours , various metastatic deposits , and primary brain lymphomas . | NA | {
"id": "C0017638",
"name": "gliomas",
"pos": [
107,
114
]
} | {
"id": "C0025149",
"name": "medulloblastomas",
"pos": [
145,
161
]
} |
this was probably due to the fact that , in the majority of patients , cavernous sinus symptoms were either the first expression of an unknown malignancy or the first manifestation of metastatic disease in those with a known primary . | NA | {
"id": "C0027667",
"name": "unknown malignancy",
"pos": [
135,
153
]
} | {
"id": "C0027627",
"name": "metastatic disease",
"pos": [
184,
202
]
} |
the f- contents of the dentifrices were : a = 1000 ppm f as na2po3f + 450 ppm f as naf ; | NA | {
"id": "C0016327",
"name": "f",
"pos": [
4,
5
]
} | {
"id": "C0037508",
"name": "naf",
"pos": [
83,
86
]
} |
statistical analysis showed a significantly higher f- level from the naf-based paste b than that from all other systems . | NA | {
"id": "C0016327",
"name": "f",
"pos": [
35,
36
]
} | {
"id": "C0037508",
"name": "naf",
"pos": [
69,
72
]
} |
consideration of the anion dissociation constants and the ca-anion association constants of the salts suggests that the observed inhibition is caused mainly by common ion effects and , to a lesser extent , by buffer effects . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
21,
26
]
} | {
"id": "C0022023",
"name": "ion",
"pos": [
167,
170
]
} |
the greatest variation appeared at the first dentin step between the palladium-silver and high-gold alloys and between the palladium-silver and base metal alloys . | NA | {
"id": "C0018027",
"name": "gold alloys",
"pos": [
95,
106
]
} | {
"id": "C0002154",
"name": "alloys",
"pos": [
155,
161
]
} |
as a result of the theft of dental students ' gold issue , use of a less expensive technique alloy in a preclinical course was evaluated as a substitute for conventional gold alloy . | NA | {
"id": "C0002154",
"name": "alloy",
"pos": [
93,
98
]
} | {
"id": "C0018027",
"name": "gold alloy",
"pos": [
170,
180
]
} |
one group of students used a conventional gold alloy and a second group used a technique alloy . | NA | {
"id": "C0018027",
"name": "gold",
"pos": [
42,
46
]
} | {
"id": "C0002154",
"name": "alloy",
"pos": [
89,
94
]
} |
hypokinesia , usually rapidly progressing to dyskinesia , began 19 +/- 8 seconds ( mean +/- sd ) after coronary occlusion . | NA | {
"id": "C0086439",
"name": "hypokinesia",
"pos": [
0,
11
]
} | {
"id": "C0013384",
"name": "dyskinesia",
"pos": [
45,
55
]
} |
of 39 patients with av reciprocating tachycardia utilizing left-sided bypass tracts for retrograde conduction , intravenous infusion of verapamil ( 0.15 mg/kg ) terminated the tachycardia in 31 patients . | NA | {
"id": "C0242514",
"name": "reciprocating tachycardia",
"pos": [
23,
48
]
} | {
"id": "C0039231",
"name": "tachycardia",
"pos": [
176,
187
]
} |
relations among plasma epinephrine , norepinephrine and renin activity and systolic pressure , diastolic pressure , heart rate and the product of heart rate and systolic pressure ( rate-pressure product ) were evaluated in 31 healthy men whose arterial pressure spanned the range from normal to mildly elevated . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
23,
34
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
37,
51
]
} |
in the supine position , highly significant regressions were found between systolic pressure or rate-pressure product and plasma epinephrine , but not between these variables and norepinephrine or renin activity . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
129,
140
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
179,
193
]
} |
weakly significant correlations between systolic pressure and epinephrine and between heart rate and norepinephrine and epinephrine were also found . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
101,
115
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
120,
131
]
} |
eight monoclonal anti-human igg antibodies were fully characterized and evaluated as possible reagents in solid phase radioimmunoassay for quantitating allergen-specific igg antibody . | NA | {
"id": "C0003250",
"name": "monoclonal",
"pos": [
6,
16
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
174,
182
]
} |
these monoclonal antibodies were more suitable than polyclonal rabbit anti-human igg antibody in phadebas rast for honey bee venom-specific igg antibody . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
6,
27
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
144,
152
]
} |
these advantages of monoclonal antibodies that recognize ch2 domain of human igg made it possible to quantitate egg white- and dermatophagoides pteronyssinus-specific igg antibodies with use of allergen disks prepared for ige rast . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
20,
41
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
171,
181
]
} |
distribution of tissue polypeptide antigen ( tpa ) in normal human tissues : immunohistochemical study on unfixed , methanol- , ethanol- , and formalin-fixed tissues . | NA | {
"id": "C0001963",
"name": "methanol",
"pos": [
116,
124
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
128,
135
]
} |
the distribution of tissue polypeptide antigen ( tpa ) was studied in unfixed , methanol- , 95 % ethanol-1 % acetic acid ( ea ) - , and formalin-fixed paraffin-embedded sections of all adult human tissues using an indirect immunoperoxidase method . | NA | {
"id": "C0001963",
"name": "methanol",
"pos": [
80,
88
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
97,
104
]
} |
induction of h-y-specific cytotoxic t lymphocyte ( ctl ) responses in nonresponder female mice was attempted by i.v . injection of allogeneic male cells , followed by in vitro restimulation of recipient spleen cells with syngeneic male cells . | NA | {
"id": "C3485979",
"name": "allogeneic",
"pos": [
131,
141
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
236,
241
]
} |
lipopolysaccharide ( lps ) fraction of endotoxin induces a significant potentiation of the antigen-specific proliferative response of t helper ( th ) cell lines . | NA | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
0,
18
]
} | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
39,
48
]
} |
this effect was obtained with lps from different bacterial sources and reproduced with the lipid a moiety of endotoxin . | NA | {
"id": "C0023810",
"name": "lps",
"pos": [
30,
33
]
} | {
"id": "C0023767",
"name": "lipid a",
"pos": [
91,
98
]
} |
this effect was obtained with lps from different bacterial sources and reproduced with the lipid a moiety of endotoxin . | NA | {
"id": "C0023810",
"name": "lps",
"pos": [
30,
33
]
} | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
109,
118
]
} |
experiments which examined the dna repair capacity of irradiated cells indicated that sle fibroblasts may be able to excise certain dna lesions as well as normal cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
90,
101
]
} | {
"id": "C0007634",
"name": "normal cells",
"pos": [
155,
167
]
} |
one signal is produced by the phorbol ester , phorbol myristate acetate , and the other by either phytohemagglutinin or antibodies to t3 . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
30,
43
]
} | {
"id": "C0039654",
"name": "phorbol myristate acetate",
"pos": [
46,
71
]
} |
these results suggest that ril 2 , in addition to being a t cell growth factor , may exhibit other activities through induction of lt and ifn-gamma . | NA | {
"id": "C0218986",
"name": "ril 2",
"pos": [
27,
32
]
} | {
"id": "C0021756",
"name": "t cell growth factor",
"pos": [
58,
78
]
} |
all macrophage-activating factor detected by these assays was also removed by passing the lymphokines over a sepharose column to which the monoclonal anti-ifn-gamma antibody had been coupled . | NA | {
"id": "C0079786",
"name": "macrophage-activating factor",
"pos": [
4,
32
]
} | {
"id": "C0024297",
"name": "lymphokines",
"pos": [
90,
101
]
} |
these three antibodies were investigated for ability to inhibit t cell proliferation and interleukin 2 ( il 2 ) receptor acquisition ( determined with anti-tac antibody in an immunofluorescence assay ) induced by the lectin mitogen phytohemagglutinin ( pha ) or by the phorbol ester 12-o-tetradecanoyl-phorbol-13 acetate... | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
269,
282
]
} | {
"id": "C0039654",
"name": "phorbol",
"pos": [
302,
309
]
} |
furthermore , ds inhibited the il 2-dependent generation of cytotoxic effector cells in vitro in the absence of allogeneic stimulator cells . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
3,
6
]
} | {
"id": "C3485979",
"name": "allogeneic",
"pos": [
112,
122
]
} |
one such pool of antiserum , a cb6f1 anti-cms 4 ( pool xiv ) serum , was used to investigate the nature of the t cell regulatory structures recognized by these antibodies . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
17,
26
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
160,
170
]
} |
to assign possible positions of antigenic determinants of these and other anti-h-2dd antibodies , we compared primary sequences of seven h-2 antigens and searched for correspondence between the pattern of amino acid substitutions in the n domain , allowing 15 positions to be assigned for the antigenic sites . | NA | {
"id": "C0003316",
"name": "antigenic determinants",
"pos": [
32,
54
]
} | {
"id": "C0003320",
"name": "antigenic",
"pos": [
293,
302
]
} |
elimination of terminal complement intermediates from the plasma membrane of nucleated cells : the rate of disappearance differs for cells carrying c5b-7 or c5b-8 or a mixture of c5b-8 with a limited number of c5b-9 . | NA | {
"id": "C0009498",
"name": "complement",
"pos": [
24,
34
]
} | {
"id": "C0009545",
"name": "c5b-9",
"pos": [
210,
215
]
} |
in our studies on the effects of purine compounds on immune responses in vitro , we found that 2-chloroadenosine ( 2-cl ado ) exhibited a potent lethal effect on a viability of mouse adherent cells derived from the peritoneal cavity . | NA | {
"id": "C0000275",
"name": "2-chloroadenosine",
"pos": [
95,
112
]
} | {
"id": "C0001443",
"name": "ado",
"pos": [
120,
123
]
} |
when the major structural lipid phosphatidyl choline was replaced by dipalmitoyl phosphatidyl choline , a synthetic phospholipid with no oxidizable double bonds , the resultant liposomes were totally resistant to lysis by the mpo-h2o2-chloride system . | NA | {
"id": "C1959616",
"name": "phosphatidyl",
"pos": [
32,
44
]
} | {
"id": "C0000039",
"name": "dipalmitoyl phosphatidyl choline",
"pos": [
69,
101
]
} |
in addition to the analysis of ars-immune sera pooled from several mice , we have examined 20 individual a/j mice to determine whether the relative serum levels of idcr- and id-bearing antibodies are strictly regulated relative to each other . | NA | {
"id": "C0020960",
"name": "immune sera",
"pos": [
35,
46
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
185,
195
]
} |
the purified immunoglobulin is essentially free of contaminating mouse albumin , transferrin , and other ascites proteins , as determined by sds-polyacrylamide gel electrophoresis . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
71,
78
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
113,
121
]
} |
furthermore , the kif degradation proteins were then examined for their ability to bind anti-kif autoantibodies by immunoblot and for their immunogenicity . | NA | {
"id": "C0010803",
"name": "kif",
"pos": [
18,
21
]
} | {
"id": "C0021769",
"name": "kif",
"pos": [
93,
96
]
} |
the experiments demonstrated that : ( 1 ) kif are degraded by serine proteinases , ( 2 ) with prolonged incubation time intact kif are progressively replaced by more granular-amorphous material in transmission electron microscopy , ( 3 ) anti-kif autoantibodies bind to kif degradation proteins , ( 4 ) preincubation of ... | NA | {
"id": "C0010803",
"name": "kif",
"pos": [
42,
45
]
} | {
"id": "C0021769",
"name": "kif",
"pos": [
568,
571
]
} |
since the action spectra were similar to those for keratinocyte damage , i.e. , sunburn cell formation , induction of unscheduled dna synthesis , and to those for uvr-induced erythema , we conclude that common mechanisms underlie these types of tissue damage . | NA | {
"id": "C0022567",
"name": "damage",
"pos": [
64,
70
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
88,
92
]
} |
to confirm this hypothesis , the avian antiserum was compared to both mammalian polyclonal ( rabbit ) and monoclonal ( mouse ) antibody in vitro . beta 2m fixed to plastic surfaces combined with more avian than mammalian antibody . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
39,
48
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
221,
229
]
} |
immunologic sensitization to rubella virus was assessed from six months to eight years ( mean , 3.0 years ) after the last course of rubella virus vaccine by using hai , enzyme-linked immunosorbent assay ( elisa ) , single radial hemolysis ( srh ) , neutralization , and virus-specific lymphoproliferative techniques . | NA | {
"id": "C0035924",
"name": "rubella virus",
"pos": [
29,
42
]
} | {
"id": "C0035923",
"name": "rubella virus vaccine",
"pos": [
133,
154
]
} |
we demonstrated ige and igg antibodies to human ( rdna ) insulin as well as to bovine and porcine insulin in the serum of two patients with systemic insulin allergy by an enzyme-linked immunosorbent assay . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
57,
64
]
} | {
"id": "C0724601",
"name": "porcine insulin",
"pos": [
90,
105
]
} |
therefore , human insulin for these two patients will not eliminate insulin allergy in all patients with systemic allergy to animal insulin , because there are patients whose antibodies recognize determinants common to commercial human , bovine , and porcine insulin . | NA | {
"id": "C0795635",
"name": "human insulin",
"pos": [
12,
25
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
259,
266
]
} |
therefore , human insulin for these two patients will not eliminate insulin allergy in all patients with systemic allergy to animal insulin , because there are patients whose antibodies recognize determinants common to commercial human , bovine , and porcine insulin . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
18,
25
]
} | {
"id": "C0724601",
"name": "porcine insulin",
"pos": [
251,
266
]
} |
3 ) in addition to thymocyte proliferative activity , il-1 induces an increase in the serum titer of the acute phase protein known as serum amyloid a . | NA | {
"id": "C0001347",
"name": "acute",
"pos": [
105,
110
]
} | {
"id": "C0002723",
"name": "serum amyloid a",
"pos": [
134,
149
]
} |
the ratio ( r ) of oestrogens to pregnanediol in urine has been used as an index of oestrogen exposure relative to progesterone . | NA | {
"id": "C0033004",
"name": "pregnanediol",
"pos": [
33,
45
]
} | {
"id": "C0033308",
"name": "progesterone",
"pos": [
115,
127
]
} |
raising the arterial blood pressure by 20-33 mmhg with adrenaline and noradrenaline failed to account for the increase in arterial plasma k+ concentration produced by the two peptides . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
55,
65
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
70,
83
]
} |
the addition of trac cells to either peripheral blood mononuclear cells or non-t cells from a patient with hyper-igm syndrome resulted in new secretion of igg , with a concomitant decrease in igm secretion , whereas control t cells were not effective in inducing secretion of any isotype other than igm . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
0,
3
]
} | {
"id": "C1321301",
"name": "peripheral blood mononuclear cells",
"pos": [
37,
71
]
} |
along with previous studies on rna-binding proteins such as sm , rnp , ro , and la , the present findings suggest that nucleic acid-binding proteins , as a class , may be particularly frequent targets of autoimmunity in sle and related disorders . | NA | {
"id": "C0085177",
"name": "rna-binding",
"pos": [
31,
42
]
} | {
"id": "C0035544",
"name": "rnp",
"pos": [
65,
68
]
} |
rheumatoid antibody produced in the immune complex- or lps-induced responses is fc specific and has relatively low affinity for igg that is not bound to antigen . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
11,
19
]
} | {
"id": "C0003313",
"name": "immune complex",
"pos": [
36,
50
]
} |
in addition , the results clearly demonstrate that monoclonal antibodies q1 , cc1 and ch2 are directed against hsv type-common epitopes while v1 and t2t1 antibodies are against hsv-2-specific epitopes on the enzyme . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
51,
72
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
154,
164
]
} |
stability of the n protein , limited genetic evolution of the m1 protein probably implicated in transcription and replication of the virus , and reduction of the quantity of the membrane proteins g and m2 were general characteristics of our three pi cell lines . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
19,
26
]
} | {
"id": "C0025252",
"name": "membrane proteins",
"pos": [
178,
195
]
} |
hybridization of 35s-labelled recombinant phage dna to southern blots with dna of the different strains leads to the conclusion that prdna units are present as multimers in tandem formation at both genomic termini in the same orientation . | NA | {
"id": "C0012931",
"name": "recombinant",
"pos": [
30,
41
]
} | {
"id": "C0012854",
"name": "prdna",
"pos": [
133,
138
]
} |
neutralizing monoclonal antibodies incorporated into plaque assay overlay medium were used to select antibody-resistant ( abr ) mutants of both the herts ( using antifusion protein monoclonal 481 ) and beaudette c ( using anti-haemagglutinin-neuraminidase protein monoclonal 445 ) strains of newcastle disease virus at t... | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
13,
34
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
101,
109
]
} |
five patients with chronic non-a , non-b hepatitis were entered into a pilot therapeutic study of the antiviral agent acyclovir [ 9- ( 2-hydroxyethoxymethyl ) guanine ] . | NA | {
"id": "C0001367",
"name": "acyclovir",
"pos": [
118,
127
]
} | {
"id": "C0018321",
"name": "guanine",
"pos": [
159,
166
]
} |
we investigated the seroepidemiology of infection due to epstein-barr virus ( ebv ) in 181 south indian subjects aged 0-25 years using the indirect immunofluorescence method to titrate antibodies to viral capsid antigen ( vca ) , nuclear antigen ( ebna ) , and early antigen ( ea ) . | NA | {
"id": "C0069115",
"name": "nuclear antigen",
"pos": [
230,
245
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
267,
274
]
} |
these results are similar to data from areas where ebv-associated burkitt 's lymphoma is endemic and indicate a high ebv infection load early in life . | NA | {
"id": "C0006413",
"name": "burkitt 's lymphoma",
"pos": [
66,
85
]
} | {
"id": "C0149678",
"name": "ebv infection",
"pos": [
117,
130
]
} |
the primary surgical objective is to decompress the mass by evacuating the cyst contents and removing nonadherent portions of the tumor capsule ; | NA | {
"id": "C0010709",
"name": "cyst",
"pos": [
75,
79
]
} | {
"id": "C0027651",
"name": "tumor",
"pos": [
130,
135
]
} |
syntheses and specific activity determinations of no-carrier-added ( nca ) f-18-labeled butyrophenone neuroleptics -- benperidol , haloperidol , spiroperidol , and pipamperone . | NA | {
"id": "C0006525",
"name": "butyrophenone",
"pos": [
88,
101
]
} | {
"id": "C0005013",
"name": "benperidol",
"pos": [
118,
128
]
} |
syntheses and specific activity determinations of no-carrier-added ( nca ) f-18-labeled butyrophenone neuroleptics -- benperidol , haloperidol , spiroperidol , and pipamperone . | NA | {
"id": "C0006525",
"name": "butyrophenone",
"pos": [
88,
101
]
} | {
"id": "C0037956",
"name": "spiroperidol",
"pos": [
145,
157
]
} |
a general method for the syntheses of no-carrier-added ( nca ) 18f-labeled butyrophenone neuroleptics -- benperidol , haloperidol , spiroperidol , and pipamperone is described . | NA | {
"id": "C0006525",
"name": "butyrophenone",
"pos": [
75,
88
]
} | {
"id": "C0005013",
"name": "benperidol",
"pos": [
105,
115
]
} |
a general method for the syntheses of no-carrier-added ( nca ) 18f-labeled butyrophenone neuroleptics -- benperidol , haloperidol , spiroperidol , and pipamperone is described . | NA | {
"id": "C0006525",
"name": "butyrophenone",
"pos": [
75,
88
]
} | {
"id": "C0037956",
"name": "spiroperidol",
"pos": [
132,
144
]
} |
absorption was estimated by the appearance of radioactivity in lymph over a 24-h collection period , and the lymph lipoprotein distributions and lipoprotein lipid distribution were determined in the 24-h samples . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
115,
126
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
157,
162
]
} |
the distributions of each fatty acid among major lymph lipoproteins were similar with 93-95 % recovered in chylomicrons and very low density lipoprotein ( vldl ) fractions . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
55,
67
]
} | {
"id": "C0008731",
"name": "chylomicrons",
"pos": [
107,
119
]
} |
the distributions of each fatty acid among major lymph lipoproteins were similar with 93-95 % recovered in chylomicrons and very low density lipoprotein ( vldl ) fractions . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
55,
67
]
} | {
"id": "C0023825",
"name": "very low density lipoprotein",
"pos": [
124,
152
]
} |
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