text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
these studies suggest that unesterified eicosapentaenoic acid is absorbed efficiently into the lymphatic system , and has lymph lipoprotein and lipid distribution comparable to those of the more typical mono- and polyunsaturated fatty acids . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
128,
139
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
144,
149
]
} |
the disaccharide effect of sucrose feeding on glucuronide excretion and bile concentration of injected phenolphthalein in guinea pigs . | NA | {
"id": "C0012611",
"name": "disaccharide",
"pos": [
4,
16
]
} | {
"id": "C0038636",
"name": "sucrose",
"pos": [
27,
34
]
} |
conversely , the familial forms of cholestasis , either neonatal hepatitis or instances of intrahepatic cholestasis , are most likely genetic diseases that represent specific defects in the hepatic excretory process or in the bile secretory apparatus . | NA | {
"id": "C0008370",
"name": "cholestasis",
"pos": [
35,
46
]
} | {
"id": "C0008372",
"name": "intrahepatic cholestasis",
"pos": [
91,
115
]
} |
basal levels of th activity , epinephrine and norepinephrine are significantly higher in the adrenal glands of ls mice by 87 , 20 , and 26 % , respectively . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
30,
41
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
46,
60
]
} |
the corresponding adrenal gland catecholamine levels are unchanged in the ls and ss mice at all times measured except at 125 min in ls mice when both epinephrine ( 24 % ) and norepinephrine ( 31 % ) are decreased . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
150,
161
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
175,
189
]
} |
in contrast , the nature of the covalent binding to albumin and histone protein appears different from that to microsomal protein in that most of the binding was stable to mild acid . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
52,
59
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
122,
129
]
} |
similar results were obtained with pb and heptabarbital , two barbiturates that ( unlike thiopental ) are not racemic mixtures and are therefore more suitable for this investigation . | NA | {
"id": "C0031412",
"name": "pb",
"pos": [
35,
37
]
} | {
"id": "C0004745",
"name": "barbiturates",
"pos": [
62,
74
]
} |
in experiments designed to target opiate receptor subtypes , long-term treatment with naltrexone was found to produce a coordinated up-regulation of brain mu and delta receptors , but did not cause a significant change in the density or affinity of kappa or sigma receptors . | NA | {
"id": "C0034801",
"name": "opiate receptor",
"pos": [
34,
49
]
} | {
"id": "C0140057",
"name": "delta receptors",
"pos": [
162,
177
]
} |
in experiments designed to target opiate receptor subtypes , long-term treatment with naltrexone was found to produce a coordinated up-regulation of brain mu and delta receptors , but did not cause a significant change in the density or affinity of kappa or sigma receptors . | NA | {
"id": "C0034801",
"name": "opiate receptor",
"pos": [
34,
49
]
} | {
"id": "C0074504",
"name": "sigma",
"pos": [
258,
263
]
} |
involvement of epinephrine in the presynaptic beta adrenoceptor mechanism of norepinephrine release from rat hypothalamic slices . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
15,
26
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
77,
91
]
} |
other findings of interest were ( i ) trifluoperazine caused a small , sometimes significant ( p less than 0.05 ) , increase in uterine pg output , ( ii ) exogenous arachidonic acid failed to increase pgf-2 alpha output from the day 15 uterus in contrast to the stimulant action of a23187 , and ( iii ) exogenous arachid... | NA | {
"id": "C0033554",
"name": "pg",
"pos": [
136,
138
]
} | {
"id": "C0033559",
"name": "pge",
"pos": [
372,
375
]
} |
amino acid derived latent isocyanates : irreversible inactivation of porcine pancreatic elastase and human leukocyte elastase . | NA | {
"id": "C0030306",
"name": "pancreatic elastase",
"pos": [
77,
96
]
} | {
"id": "C0064833",
"name": "human leukocyte elastase",
"pos": [
101,
125
]
} |
several amino acid derived azolides ( i ) have been synthesized and investigated for their inhibitory activity toward human leukocyte elastase and porcine pancreatic elastase . | NA | {
"id": "C0064833",
"name": "human leukocyte elastase",
"pos": [
118,
142
]
} | {
"id": "C0030306",
"name": "pancreatic elastase",
"pos": [
155,
174
]
} |
tests with double-aldehyde-stabilised cells-treated sequentially with pyruvic aldehyde , tannic acid and glutaraldehyde-were more sensitive than tests with the cells treated only with formaldehyde , glutaraldehyde or pyruvic aldehyde , and subsequently tanned . | NA | {
"id": "C0001992",
"name": "aldehyde",
"pos": [
18,
26
]
} | {
"id": "C0017814",
"name": "glutaraldehyde",
"pos": [
199,
213
]
} |
the mc29 virus-coded protein p110gag-myc was found exclusively in the nucleus of transformed japanese quail ( q8 ) cells , and time course experiments indicated that the protein had a half-life of about 30 min . | NA | {
"id": "C0042736",
"name": "virus",
"pos": [
9,
14
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
170,
177
]
} |
using both northern blot and s1 nuclease analyses , we show here that the 3.5-kb rna is the predominant viral rna species in 6m2 cells grown at 28 degrees c , whereas only the 4.0-kb rna is detected at 39 degrees c . | NA | {
"id": "C0035736",
"name": "viral rna",
"pos": [
104,
113
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
183,
186
]
} |
in sharp contrast , however , 6m2 cells chronically superinfected with moloney murine leukemia virus produce a 3.5-kb rna species at 39 degrees c as well as at 28 degrees c and contain proviral dnas corresponding to the two viral rna species . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
118,
121
]
} | {
"id": "C0035736",
"name": "viral",
"pos": [
224,
229
]
} |
murine sarcoma virus ts110 rna transcripts : origin from a single proviral dna and sequence of the gag-mos junctions in both the precursor and spliced viral rnas . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
27,
30
]
} | {
"id": "C0035736",
"name": "viral",
"pos": [
151,
156
]
} |
four additional groups of monoclonal antibodies appear to react with discontinuous epitopes of gd-1 , since the reactivity of these antibodies was lost when the glycoprotein was denatured by reduction and alkylation . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
26,
47
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
132,
142
]
} |
thus , the viral glycoprotein antigens can be important in determining the immunogenicity of the virus and , particularly , the class i antigen-restricted tc cell response of the host . | NA | {
"id": "C0003342",
"name": "immunogenicity",
"pos": [
75,
89
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
136,
143
]
} |
these included sister chromatid exchanges , a variety of chromosomal abnormalities ( ring chromosomes , acentric fragments , breaks , and gaps ) , and an increase in the chromosome number . | NA | {
"id": "C0008626",
"name": "of chromosomal abnormalities",
"pos": [
54,
82
]
} | {
"id": "C0035639",
"name": "ring chromosomes",
"pos": [
85,
101
]
} |
we identified 3 groups : group 1-85 patients with gross hematuria or microscopic hematuria and shock after blunt trauma ( including all 23 with significant renal injuries ) , group 2-221 patients with microscopic hematuria but no shock after blunt trauma ( all with renal contusions ) and group 3-53 patients with penetr... | NA | {
"id": "C0043253",
"name": "blunt trauma",
"pos": [
107,
119
]
} | {
"id": "C0009938",
"name": "contusions",
"pos": [
272,
282
]
} |
however , because all patients in group 2 had renal contusions and experienced no complications from nonoperative management we believe that excretory urography , which is time-consuming and costly , can be avoided in patients with microscopic hematuria but no shock after blunt renal trauma . | NA | {
"id": "C0009938",
"name": "contusions",
"pos": [
52,
62
]
} | {
"id": "C0043253",
"name": "blunt",
"pos": [
273,
278
]
} |
highest success rates were in the nonoverweight mild hypertensives with sodium restriction ( 78 % ) and the overweight mild hypertensives who were reducing their weight ( 72 % ) . | NA | {
"id": "C0497406",
"name": "overweight",
"pos": [
37,
47
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
162,
168
]
} |
no significant change in plasma bradykinin or urinary excretion rate of kallikrein was observed , whereas a slight increase was observed in the urinary excretion rate of kinins after mk-421 in 8 patients . | NA | {
"id": "C0006100",
"name": "bradykinin",
"pos": [
32,
42
]
} | {
"id": "C0022714",
"name": "kinins",
"pos": [
170,
176
]
} |
the role of viral antigens acting alone or in concert with cellular antigens is discussed . | NA | {
"id": "C0003342",
"name": "viral antigens",
"pos": [
12,
26
]
} | {
"id": "C0003320",
"name": "antigens",
"pos": [
68,
76
]
} |
lps preparations from s. minnesota r5 and endotoxin-free cell wall residues of r5 and r7 mutants of s. minnesota had no stimulatory effect on these cells . | NA | {
"id": "C0023810",
"name": "lps",
"pos": [
0,
3
]
} | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
42,
51
]
} |
these results support the concept that endotoxins are involved in the etiology of sma occlusion shock and that anti-lps therapy may therefore be useful in the prevention of endotoxic shock . | NA | {
"id": "C0014264",
"name": "endotoxins",
"pos": [
39,
49
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
116,
119
]
} |
the results show a high incidence of cytosolic estrogen and glucocorticoid receptors in tumors of adipose tissue origin except in lipoma and well differentiated liposarcoma . | NA | {
"id": "C0206631",
"name": "tumors of adipose tissue",
"pos": [
88,
112
]
} | {
"id": "C0023798",
"name": "lipoma",
"pos": [
130,
136
]
} |
these results are further evidence of the emergence of a clinically atypical form of kaposi 's sarcoma in africans , which resembles that seen in american patients with aids , and which is associated with htlv-iii infection . | NA | {
"id": "C0001175",
"name": "aids",
"pos": [
169,
173
]
} | {
"id": "C0019693",
"name": "htlv-iii infection",
"pos": [
205,
223
]
} |
the kinetics of stable isotope-labelled l-threo-3 , 4-dihydroxyphenylserine ( l-threo-dops ) , an immediate precursor of ( - ) -norepinephrine , was studied to investigate the pharmacologic mechanism of its therapeutic effect on orthostatic hypotension in familial amyloid polyneuropathy ( fap ) and on akinesia and free... | NA | {
"id": "C0000378",
"name": "l",
"pos": [
20,
21
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
128,
142
]
} |
the results indicate that the increase in norepinephrine in biological fluids after administration of l-threo-dops is attributable mostly to norepinephrine derived from l-threo-dops , not to pre-formed endogenous norepinephrine released by l-threo-dops . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
42,
56
]
} | {
"id": "C0000378",
"name": "threo-dops",
"pos": [
242,
252
]
} |
there was no protease effect on the platelet factor 4 radioimmunoassay which always showed no detectable amounts with mast cells , granules or proteases . | NA | {
"id": "C0030946",
"name": "protease",
"pos": [
13,
21
]
} | {
"id": "C0030940",
"name": "proteases",
"pos": [
143,
152
]
} |
synovial fluid pla2 did not interact with sulphated mucopolysaccharides such as heparin or chondroitin sulphate . | NA | {
"id": "C0017973",
"name": "mucopolysaccharides",
"pos": [
52,
71
]
} | {
"id": "C0019134",
"name": "heparin",
"pos": [
80,
87
]
} |
doxorubicin and daunorubicin , the anthracycline antitumor agents , were evaluated for their in vitro and in vivo effect on phosphodiesterase ( pde ) activity in mouse tissues . | NA | {
"id": "C0013089",
"name": "doxorubicin",
"pos": [
0,
11
]
} | {
"id": "C0011015",
"name": "daunorubicin",
"pos": [
16,
28
]
} |
trh has rapid-onset ( 30 sec ) , slow-offset ( 1-12 days ) clinical benefit in patients with amyotrophic lateral sclerosis and other motor neuron disorders . | NA | {
"id": "C0002736",
"name": "amyotrophic lateral sclerosis",
"pos": [
93,
122
]
} | {
"id": "C0085084",
"name": "motor neuron disorders",
"pos": [
133,
155
]
} |
steady state accumulation of labelled amino acids ( glycine , lysine and aspartic acid ) was affected under these conditions . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
38,
49
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
52,
59
]
} |
it provides an opportunity to give up corticosteroids in more than 60 % of patients and to decrease the hormone dose in the rest of cortisone-dependent patients with bronchial asthma . | NA | {
"id": "C0001617",
"name": "corticosteroids",
"pos": [
38,
53
]
} | {
"id": "C0019932",
"name": "hormone",
"pos": [
104,
111
]
} |
nitrogen balance during this period had a significant direct correlation with pre-diet concentrations of branched-chain amino acids ( r = 0.69 to 0.89 ) , methionine ( r = 0.85 ) , histidine ( r = 0.66 ) , alanine ( r = 0.73 ) , arginine ( r = 0.70 ) , ornithine ( r = 0.66 ) , total essential ( r = 0.87 , and nonessent... | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
206,
213
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
337,
348
]
} |
impairment of induction of delta-aminolevulinic acid synthase by gluconeogenic amino acids and carbohydrates in vitro . | NA | {
"id": "C0002563",
"name": "delta-aminolevulinic acid",
"pos": [
27,
52
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
79,
90
]
} |
epinephrine rose transiently after 5 minutes of naloxone but was unchanged during dmpe , and norepinephrine was unchanged throughout . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
0,
11
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
93,
107
]
} |
furthermore , mesenteric artery relaxation was found to be decreased in response to the cyclic amp analogue dibutyryl cyclic amp ( 45 +/- 2.0 vs. 28 +/- 2.0 % ; p less than 0.001 ) in the epinephrine-infused rats . | NA | {
"id": "C0001455",
"name": "cyclic amp",
"pos": [
88,
98
]
} | {
"id": "C0012054",
"name": "dibutyryl cyclic",
"pos": [
108,
124
]
} |
prior incubation of aged membranes with isoproterenol and gmp restored subsequent stimulation by gpp ( nh ) p , presumably due to the clearance of inhibitory gdp tightly bound to the guanine nucleotide regulatory components in aged membranes . | NA | {
"id": "C0018346",
"name": "gmp",
"pos": [
58,
61
]
} | {
"id": "C0018328",
"name": "guanine nucleotide",
"pos": [
183,
201
]
} |
prior incubation of aged membranes with isoproterenol and gmp restored subsequent stimulation by gpp ( nh ) p , presumably due to the clearance of inhibitory gdp tightly bound to the guanine nucleotide regulatory components in aged membranes . | NA | {
"id": "C0018340",
"name": "gdp",
"pos": [
158,
161
]
} | {
"id": "C0018328",
"name": "guanine nucleotide",
"pos": [
183,
201
]
} |
likewise , the effects of these drugs on rrna processing resulted in their classification into two groups : toyocamycin , 5-fluorouracil , and tubercidin caused an abnormal accumulation of the 45 s precursor to rrna , while sangivamycin , 8-azaguanine , and 5-azacytidine did not cause an accumulation of 45 s rna . | NA | {
"id": "C0035701",
"name": "rrna",
"pos": [
41,
45
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
310,
313
]
} |
ta104 is reverted efficiently by formaldehyde , alpha , beta-unsaturated aldehydes ( enals ) , and dicarbonyl compounds , such as diacetyl and glutaraldehyde . | NA | {
"id": "C0001992",
"name": "aldehydes",
"pos": [
73,
82
]
} | {
"id": "C0017814",
"name": "glutaraldehyde",
"pos": [
143,
157
]
} |
effects of x-irradiation on cell-cycle progression , induction of chromosomal aberrations and cell killing in ataxia telangiectasia ( at ) fibroblasts . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
28,
32
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
139,
150
]
} |
homozygotic at ( proband ) fibroblasts were very hypersensitive to cell killing by x-irradiation ( d0 = 40-45 rad ) . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
27,
38
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
67,
71
]
} |
total protein output and albumin : protein ratios were not increased in secretions from the patients , but their fluid secretion was significantly decreased at any level of pancreatic function . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
25,
32
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
35,
42
]
} |
the delay in the switch from gamma-globin to beta-globin in this unique clinical setting may allow identification of physiologic factors that can modulate developmental gene suppression . | NA | {
"id": "C0017033",
"name": "gamma-globin",
"pos": [
29,
41
]
} | {
"id": "C0005221",
"name": "globin",
"pos": [
50,
56
]
} |
these results suggest that an interaction between the idiotype of monoclonal immunoglobulins and antiidiotypic antibodies causes increased consumption of c1q and c1 inhibitor in patients with acquired angioedema and c1-inhibitor deficiency . | NA | {
"id": "C0003250",
"name": "monoclonal immunoglobulins",
"pos": [
66,
92
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
111,
121
]
} |
we now present evidence that activation of endogenous protein kinase c by the tumour-promoting phorbol ester tpa ( 12-o-tetradecanoyl- phorbol-13-acetate ) , or intracellular injection of the purified enzyme , enhances the voltage-sensitive calcium current in bag cell neurones of the mollusc aplysia . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
95,
108
]
} | {
"id": "C0039654",
"name": "12-o-tetradecanoyl",
"pos": [
115,
133
]
} |
however , either one in combination with the phorbol ester 12-o-tetradecanoylphorbol 13-acetate ( tpa ) , which is structurally related to 1,2-diacylglycerol , induces in lymphoid cell populations the expression of receptors for interleukin-2 ( il-2 ) , the secretion of il-2 and cell proliferation as measured by 3h-thy... | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
45,
58
]
} | {
"id": "C0039654",
"name": "12-o-tetradecanoylphorbol 13-acetate",
"pos": [
59,
95
]
} |
white blood cell dna from cancer patients and dna from tumours and tumour-derived cell lines frequently demonstrated allelic restriction fragments of the harvey ras oncogene locus not found in the unaffected population . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
17,
20
]
} | {
"id": "C0012930",
"name": "dna",
"pos": [
46,
49
]
} |
retinoic acid ( ra ) , an analogue of vitamin a , has been shown to inhibit neuroblastoma cell growth and clonability in soft agar , and to induce extensive neurite outgrowth . | NA | {
"id": "C0040845",
"name": "retinoic acid",
"pos": [
0,
13
]
} | {
"id": "C0042839",
"name": "vitamin a",
"pos": [
38,
47
]
} |
furthermore , 'opportunistic ' mitogens ( those that do not act on the cells in vivo , such as concanavalin a ( con a ) , the ca2+ ionophore a23187 and 12-o-tetradecanoyl phorbol 13-acetate ctpa ] that are mitogenic for both mouse thymocytes and 3t3 fibroblast , each produce characteristic ionic responses that are the ... | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
71,
76
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
250,
260
]
} |
tgfs comprise two distinct sets of molecules : tgf-alpha s are structurally similar to epidermal growth factor ( egf ) , binding to and inducing the tyrosine phosphorylation of the egf receptor in a manner indistinguishable from that of egf . | NA | {
"id": "C0040691",
"name": "tgfs",
"pos": [
0,
4
]
} | {
"id": "C0040688",
"name": "tgf-alpha",
"pos": [
47,
56
]
} |
epinephrine ( e ) , norepinephrine ( ne ) and the highly selective beta 2-agonist zinterol ( zin ) also stimulated c-amp accumulation . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
0,
11
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
20,
34
]
} |
since interference of beta-adrenergic effects on contaminating fibroblasts or endothelial cells could be reasonably excluded , the present data suggest that beta-adrenergic stimulation of c-amp accumulation in anterior pituitary cells elicits gh and prl release . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
63,
74
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
229,
234
]
} |
since interference of beta-adrenergic effects on contaminating fibroblasts or endothelial cells could be reasonably excluded , the present data suggest that beta-adrenergic stimulation of c-amp accumulation in anterior pituitary cells elicits gh and prl release . | NA | {
"id": "C0032016",
"name": "anterior pituitary",
"pos": [
210,
228
]
} | {
"id": "C0037663",
"name": "gh",
"pos": [
243,
245
]
} |
the effect of the beta-adrenergic agonist isoproterenol ( iso ) on c-amp accumulation and on growth hormone ( gh ) and prolactin ( prl ) release was studied in primary cultures of anterior pituitary cell populations with different proportional number of somatotrophs and lactotrophs , obtained by velocity sedimentation ... | NA | {
"id": "C0037663",
"name": "growth hormone",
"pos": [
93,
107
]
} | {
"id": "C0032016",
"name": "anterior pituitary",
"pos": [
180,
198
]
} |
low levels of the major essential fatty acid linoleate were found in plasma total lipids of patients who had malabsorption but not in those without evidence of steatorrhea . | NA | {
"id": "C0024523",
"name": "malabsorption",
"pos": [
109,
122
]
} | {
"id": "C0038238",
"name": "steatorrhea",
"pos": [
160,
171
]
} |
lcl from npd type a and type b showed a severe deficiency of acid sphingomyelinase determined using either substrate , whereas lcl from normal subjects had an activity close to that of blood leukocytes . | NA | {
"id": "C0268242",
"name": "npd type a",
"pos": [
9,
19
]
} | {
"id": "C0028064",
"name": "deficiency",
"pos": [
47,
57
]
} |
in 43 patients with cystic fibrosis ( age 8-23 yr , 26 boys and 17 girls ) attending a summer camp in a mountain rehabilitation center and in 25 parents ( heterozygotes ) plasma epinephrine , norepinephrine , dopamine and plasma activity of dopamine-beta-hydroxylase were determined as well as the 24-h excretion of the ... | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
178,
189
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
356,
370
]
} |
in 43 patients with cystic fibrosis ( age 8-23 yr , 26 boys and 17 girls ) attending a summer camp in a mountain rehabilitation center and in 25 parents ( heterozygotes ) plasma epinephrine , norepinephrine , dopamine and plasma activity of dopamine-beta-hydroxylase were determined as well as the 24-h excretion of the ... | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
178,
189
]
} | {
"id": "C0025562",
"name": "metanephrine",
"pos": [
434,
446
]
} |
in 43 patients with cystic fibrosis ( age 8-23 yr , 26 boys and 17 girls ) attending a summer camp in a mountain rehabilitation center and in 25 parents ( heterozygotes ) plasma epinephrine , norepinephrine , dopamine and plasma activity of dopamine-beta-hydroxylase were determined as well as the 24-h excretion of the ... | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
192,
206
]
} | {
"id": "C0028385",
"name": "normetanephrine",
"pos": [
431,
446
]
} |
transesophageal atrial pacing was used to initiate and terminate tachycardia in 24 infants ( seven female and 17 male , aged 1 to 34 days ) with ecg documentation of supraventricular tachycardia . | NA | {
"id": "C0039231",
"name": "tachycardia",
"pos": [
65,
76
]
} | {
"id": "C0039240",
"name": "supraventricular tachycardia",
"pos": [
166,
194
]
} |
in these 18 infants , the effectiveness of digoxin therapy in preventing the initiation of tachycardia by transesophageal pacing was compared with its ability to prevent spontaneous recurrences of supraventricular tachycardia . | NA | {
"id": "C0039231",
"name": "tachycardia",
"pos": [
91,
102
]
} | {
"id": "C0039240",
"name": "supraventricular tachycardia",
"pos": [
197,
225
]
} |
sixty-four percent of all head injuries , excluding uncomplicated skull fracture , and 95 % of serious intracranial injuries were the result of child abuse . | NA | {
"id": "C0018674",
"name": "of",
"pos": [
19,
21
]
} | {
"id": "C0037304",
"name": "skull fracture",
"pos": [
66,
80
]
} |
after obtaining parental informed consent , laboratory tests of iron status were performed on venous blood and infants with hemoglobin level greater than 10.5 g/dl were randomly chosen to receive 1.2 ml of ferrous sulfate ( feso4 ) drops ( about 3 mg of iron per kilogram per day ) or equal volume of placebo for 3 month... | NA | {
"id": "C0302583",
"name": "iron",
"pos": [
64,
68
]
} | {
"id": "C0060282",
"name": "ferrous sulfate",
"pos": [
206,
221
]
} |
twenty-six children received a single daily intravenous dose of ceftriaxone , 50 mg/kg , for a variety of bacterial infections including abscess ( 5 ) , cellulitis ( 5 ) , periorbital cellulitis ( 5 ) , bacteremia without focus ( 4 ) , osteomyelitis ( 2 ) , pneumonia ( 2 ) , pyelonephritis ( 2 ) and otitis media ( 1 ) ... | NA | {
"id": "C0004623",
"name": "bacterial infections",
"pos": [
106,
126
]
} | {
"id": "C0004610",
"name": "bacteremia",
"pos": [
203,
213
]
} |
we now show that the response of cells to tgf-beta is bifunctional , in that tgf-beta inhibits the anchorage-dependent growth of nrk fibroblasts and of human tumor cells by increasing cell cycle time . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
17,
20
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
133,
144
]
} |
whereas epidermal growth factor and tgf-beta synergize to induce anchorage-independent growth of nrk fibroblasts , their effects on the growth of a-549 human lung carcinoma cells are antagonistic . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
101,
112
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
173,
178
]
} |
the bifunctional response of cells to tgf-beta is further demonstrated in fischer rat 3t3 fibroblasts transfected with a cellular myc gene . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
90,
101
]
} | {
"id": "C0007634",
"name": "cellular",
"pos": [
121,
129
]
} |
though we relied on 125i-labeled alpha-bungarotoxin to distinguish wild-type from deficient clones , we found that an antiserum to the acchor , followed by a biotinylated second antibody and a horseradish peroxidase-avidin complex , could also be used . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
118,
127
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
178,
186
]
} |
the relative amount of apolipoprotein ( apo- ) e mrna in 12 different tissues of the rat and marmoset was examined by dot blot hybridization using cloned cdna probes . | NA | {
"id": "C0003591",
"name": "apolipoprotein",
"pos": [
23,
37
]
} | {
"id": "C0003595",
"name": "apo",
"pos": [
40,
43
]
} |
the other reading frame starts at a `` '' strong '' '' initiation codon about 70 residues downstream from the 5 ' terminus but extends for only about 120 codons , being terminated by 3 in-phase termination codons in all three genes . | NA | {
"id": "C0009221",
"name": "0 codo",
"pos": [
152,
158
]
} | {
"id": "C0242611",
"name": "termination codo",
"pos": [
194,
210
]
} |
sequence comparisons show that the fip gene product of escherichia coli , which is required for filamentous phage assembly , is thioredoxin . | NA | {
"id": "C0033684",
"name": "gene product",
"pos": [
39,
51
]
} | {
"id": "C0039938",
"name": "thioredoxin",
"pos": [
128,
139
]
} |
a rabbit antibody to this membrane fatty acid-binding protein gave a single precipitin line with the antigen but no reactivity with concentrated cytosolic proteins , lpm bilirubin/sulfobromophthalein-binding protein , or rat albumin or other rat plasma proteins . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
155,
163
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
225,
232
]
} |
both x and y induce morphological changes ( spreading ) , prostaglandin e2 synthesis , and killing of tumor cells by mouse peritoneal macrophages in vitro , properties with which lipopolysaccharide and lipid a are also endowed . | NA | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
179,
197
]
} | {
"id": "C0023767",
"name": "lipid a",
"pos": [
202,
209
]
} |
our results show that the monosaccharides x and y retain some of the properties of intact lipopolysaccharide and lipid a with respect to macrophage activation . | NA | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
90,
108
]
} | {
"id": "C0023767",
"name": "lipid a",
"pos": [
113,
120
]
} |
the binding of norfloxacin to dna plasmids is nonintercalative , as shown by the fact that the drug binds preferentially to single-stranded dna rather than to double-stranded dna . | NA | {
"id": "C0012935",
"name": "single-stranded dna",
"pos": [
124,
143
]
} | {
"id": "C0012854",
"name": "double-stranded dna",
"pos": [
159,
178
]
} |
phosphorylation enzymes of the propionic acid bacteria and the roles of atp inorganic pyrophosphate , and polyphosphates . | NA | {
"id": "C0034320",
"name": "pyrophosphate",
"pos": [
86,
99
]
} | {
"id": "C0032575",
"name": "polyphosphates",
"pos": [
106,
120
]
} |
covalent enzyme-rna complex : a trna modification that prevents a covalent enzyme interaction also prevents aminoacylation . | NA | {
"id": "C0026741",
"name": "enzyme",
"pos": [
9,
15
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
75,
81
]
} |
analyses of the 5 ' and 3 ' map positions of displacement-loop nucleic acids from mitochondria of cultured human cells reveal a close correspondence between the 3 ' ends of rna , whose 5 ' ends map at a unique site , and the 5 ' ends of dna strands . | NA | {
"id": "C0028606",
"name": "nucleic acids",
"pos": [
63,
76
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
237,
240
]
} |
however , in comparison with fibroblasts , the ldl receptor and 3-hydroxy-3-methylglutaryl-coenzyme a ( hmg-coa ) reductase activity in j774 cells are relatively resistant to down-regulation by ldl or 25-hydroxycholesterol , leading to receptor-mediated ce storage . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
29,
40
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
141,
146
]
} |
when the inhibitory efficacies of purine and pyrimidine bases and nucleosides were compared , their relative potencies in decreasing order were purine bases greater than purine nucleosides greater than pyrimidine bases = pyrimidine nucleosides . | NA | {
"id": "C0028621",
"name": "nucleosides",
"pos": [
66,
77
]
} | {
"id": "C0034136",
"name": "purine nucleosides",
"pos": [
170,
188
]
} |
when the inhibitory efficacies of purine and pyrimidine bases and nucleosides were compared , their relative potencies in decreasing order were purine bases greater than purine nucleosides greater than pyrimidine bases = pyrimidine nucleosides . | NA | {
"id": "C0028621",
"name": "nucleosides",
"pos": [
66,
77
]
} | {
"id": "C0034287",
"name": "pyrimidine nucleosides",
"pos": [
221,
243
]
} |
the high efficiency , approximately equal to 10-fold greater than that observed using current methods without enrichment procedures , is obtained by using a dna template containing several uracil residues in place of thymine . | NA | {
"id": "C0041917",
"name": "uracil",
"pos": [
189,
195
]
} | {
"id": "C0040087",
"name": "thymine",
"pos": [
217,
224
]
} |
these results indicate that npy acts on structures adjacent to the third ventricle to inhibit the secretion of lh and growth hormone but not follicle-stimulating hormone , whereas it can directly stimulate the secretion of all three hormones from the cells of the anterior pituitary in vitro . | NA | {
"id": "C0037663",
"name": "growth hormone",
"pos": [
118,
132
]
} | {
"id": "C0032016",
"name": "anterior pituitary",
"pos": [
264,
282
]
} |
normal human fibroblasts were fused to carcinogen-transformed baby hamster kidney ( bhk ) cells and found to be able to suppress the anchorage-independent transformed phenotype of the hamster cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
13,
24
]
} | {
"id": "C0007634",
"name": "the",
"pos": [
180,
183
]
} |
herpes simplex has become a particular problem because of the rapid increase in the frequency of genital herpes infections , the spontaneous recurrences of the lesions , and the difficulty in prevention or treating congenital infections . | NA | {
"id": "C0019348",
"name": "herpes simplex",
"pos": [
0,
14
]
} | {
"id": "C0019342",
"name": "genital herpes",
"pos": [
97,
111
]
} |
radiologically , the disease progresses from bronchial wall thickening with or without hyperinflation , to increasing hyperinflation plus parenchymal changes including segmental atelectasis , consolidation , and bronchiectasis . | NA | {
"id": "C0006261",
"name": "disease",
"pos": [
21,
28
]
} | {
"id": "C0006267",
"name": "bronchiectasis",
"pos": [
212,
226
]
} |
the fluids included abscess contents , bile , ascitic fluid , cyst and pseudocyst fluid , urine , hematomas , pleural fluid , lymphoceles , seromas , cerebrospinal fluid , pancreatic ductal fluid , and necrotic tumor . | NA | {
"id": "C0010709",
"name": "cyst",
"pos": [
62,
66
]
} | {
"id": "C0024248",
"name": "lymphoceles",
"pos": [
126,
137
]
} |
the glycosaminoglycan was identified as heparan sulfate by cellulose acetate electrophoresis and nitrous acid treatment . | NA | {
"id": "C0017973",
"name": "glycosaminoglycan",
"pos": [
4,
21
]
} | {
"id": "C0019143",
"name": "heparan sulfate",
"pos": [
40,
55
]
} |
tritiated 1,4-dihydropyridines ( nimodipine , nitrendipine , nifedipine , pn 200-110 ) and [ 3h ] d-cis-diltiazem as well as [ 3h ] verapamil were employed to directly identify calcium channels in membranes for excitable tissues . | NA | {
"id": "C0012315",
"name": "dihydropyridines",
"pos": [
14,
30
]
} | {
"id": "C0028094",
"name": "nimodipine",
"pos": [
33,
43
]
} |
tritiated 1,4-dihydropyridines ( nimodipine , nitrendipine , nifedipine , pn 200-110 ) and [ 3h ] d-cis-diltiazem as well as [ 3h ] verapamil were employed to directly identify calcium channels in membranes for excitable tissues . | NA | {
"id": "C0012315",
"name": "dihydropyridines",
"pos": [
14,
30
]
} | {
"id": "C0028127",
"name": "nitrendipine",
"pos": [
46,
58
]
} |
tritiated 1,4-dihydropyridines ( nimodipine , nitrendipine , nifedipine , pn 200-110 ) and [ 3h ] d-cis-diltiazem as well as [ 3h ] verapamil were employed to directly identify calcium channels in membranes for excitable tissues . | NA | {
"id": "C0012315",
"name": "dihydropyridines",
"pos": [
14,
30
]
} | {
"id": "C0028066",
"name": "nifedipine",
"pos": [
61,
71
]
} |
following pcs the plasma and csf concentrations of the aromatic amino acids ( aaa ) , phenylalanine and tyrosine , increased and the levels of the branched chain amino acids ( bcaa ) , valine , leucine , and isoleucine , decreased during ammonia-induced coma . | NA | {
"id": "C0301713",
"name": "aromatic amino acids",
"pos": [
55,
75
]
} | {
"id": "C0031453",
"name": "phenylalanine",
"pos": [
86,
99
]
} |
following pcs the plasma and csf concentrations of the aromatic amino acids ( aaa ) , phenylalanine and tyrosine , increased and the levels of the branched chain amino acids ( bcaa ) , valine , leucine , and isoleucine , decreased during ammonia-induced coma . | NA | {
"id": "C0301713",
"name": "aromatic amino acids",
"pos": [
55,
75
]
} | {
"id": "C0041485",
"name": "tyrosine",
"pos": [
104,
112
]
} |
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