text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
following pcs the plasma and csf concentrations of the aromatic amino acids ( aaa ) , phenylalanine and tyrosine , increased and the levels of the branched chain amino acids ( bcaa ) , valine , leucine , and isoleucine , decreased during ammonia-induced coma . | NA | {
"id": "C0002521",
"name": "branched chain amino acids",
"pos": [
147,
173
]
} | {
"id": "C0042285",
"name": "valine",
"pos": [
185,
191
]
} |
following pcs the plasma and csf concentrations of the aromatic amino acids ( aaa ) , phenylalanine and tyrosine , increased and the levels of the branched chain amino acids ( bcaa ) , valine , leucine , and isoleucine , decreased during ammonia-induced coma . | NA | {
"id": "C0002521",
"name": "branched chain amino acids",
"pos": [
147,
173
]
} | {
"id": "C0023401",
"name": "leucine",
"pos": [
211,
218
]
} |
following pcs the plasma and csf concentrations of the aromatic amino acids ( aaa ) , phenylalanine and tyrosine , increased and the levels of the branched chain amino acids ( bcaa ) , valine , leucine , and isoleucine , decreased during ammonia-induced coma . | NA | {
"id": "C0002521",
"name": "branched chain amino acids",
"pos": [
147,
173
]
} | {
"id": "C0022192",
"name": "isoleucine",
"pos": [
208,
218
]
} |
however , 2-me induced significant proliferation in the nwsc cell preparations when endotoxin-deficient culture medium was supplemented with doses of lps which alone did not stimulate significant proliferation . | NA | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
84,
93
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
150,
153
]
} |
in cscl gradients , free antigen or antibody could not be separated from the immune complexes . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
36,
44
]
} | {
"id": "C0003313",
"name": "immune complexes",
"pos": [
77,
93
]
} |
in 12 % of the patients the diagnosis was tonsillitis or pharyngitis , in 7 % bronchitis , pneumonia or asthma and in 5 % arterial hypertension . | NA | {
"id": "C0040425",
"name": "tonsillitis",
"pos": [
42,
53
]
} | {
"id": "C0031350",
"name": "pharyngitis",
"pos": [
57,
68
]
} |
despite the infusion of nahco3 , both arterial ph and bicarbonate concentration decreased by a similar amount in all three groups of dogs . | NA | {
"id": "C0074722",
"name": "nahco3",
"pos": [
24,
30
]
} | {
"id": "C0005367",
"name": "bicarbonate",
"pos": [
54,
65
]
} |
since the liver is a central organ for lipid and lipoprotein synthesis and catabolism , hepatic receptors for specific apolipoproteins on plasma lipoproteins would be expected to modulate lipid and lipoprotein metabolism . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
122,
134
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
188,
193
]
} |
the expression of myosin heavy chain isoforms was examined in normal and dystrophic chicken muscle with a monoclonal antibody specific for neonatal myosin . | NA | {
"id": "C0027100",
"name": "myosin heavy chain",
"pos": [
18,
36
]
} | {
"id": "C0027096",
"name": "myosin",
"pos": [
148,
154
]
} |
this case illustrates the uncommon association of caseating granulomas with sarcoidosis and documents hypopituitarism due to combined hypothalamic and pituitary disease caused by sarcoid infiltration . | NA | {
"id": "C0020635",
"name": "hypopituitarism",
"pos": [
102,
117
]
} | {
"id": "C0032002",
"name": "pituitary disease",
"pos": [
151,
168
]
} |
the distribution pattern of arsenic in the blood following the single oral dose of arsenic trioxide was such that inorganic arsenic and maa occurred chiefly in the blood cells ; | NA | {
"id": "C0003818",
"name": "arsenic",
"pos": [
28,
35
]
} | {
"id": "C0052416",
"name": "arsenic trioxide",
"pos": [
83,
99
]
} |
dmaa accounted for the major portion of arsenic excreted in the urine and feces , and this finding re-confirmed that dmaa is the major metabolite of arsenic trioxide . | NA | {
"id": "C0003818",
"name": "arsenic",
"pos": [
40,
47
]
} | {
"id": "C0052416",
"name": "arsenic trioxide",
"pos": [
149,
165
]
} |
anti-jmh was the only antibody to react with igg subclass antisera and was determined to be igg4 . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
22,
30
]
} | {
"id": "C0020960",
"name": "antisera",
"pos": [
58,
66
]
} |
rabbit anti-human platelet antisera ( absorbed with their specific human donor leukocytes to remove hla- and granulocyte-specific antibodies ) were combined under various conditions with human platelets and tested in a modified antiglobulin consumption test utilizing rabbit igg . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
27,
35
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
130,
140
]
} |
after 18 hours of exposure to culture medium containing 4 percent of this perfluorochemical emulsion , normal embryonic lung fibroblasts ( imr 90 cells ) and their sv40 virus-transformed counterparts ( ag 2804 cells ) ceased proliferation and showed degenerative changes , even if fluosol was washed off the cell monolay... | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
125,
136
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
210,
215
]
} |
previous studies in our laboratory demonstrated that several treatments that inhibited the ability of cells to stimulate the mixed lymphocyte reaction ( mlr ) also blocked the shedding of histocompatibility antigens and ia antigens from murine spleen cells . | NA | {
"id": "C0019628",
"name": "histocompatibility antigens",
"pos": [
188,
215
]
} | {
"id": "C0019630",
"name": "ia antigens",
"pos": [
220,
231
]
} |
trilostane afforded reduction of plasma levels of aldosterone , progesterone , deoxycorticosterone , 17-oh progesterone , cortisol , delta 4-androstenedione , and urinary excretion of 17-hydroxycorticosteroid . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
64,
76
]
} | {
"id": "C0020387",
"name": "17-oh progesterone",
"pos": [
101,
119
]
} |
the weight of ovaries with cl dropped significantly within 48 hours after cloprostenol application as compared with control ( p less than 0.001 ) and the difference in the ovary weight according to cl incidence disappeared almost completely . | NA | {
"id": "C0005910",
"name": "weight",
"pos": [
4,
10
]
} | {
"id": "C0005911",
"name": "difference",
"pos": [
154,
164
]
} |
the rapid reversion after insulin treatment excludes the possibility that streptozotocin in itself causes the iso resistance and points towards a direct insulin effect on myocardial catecholamine sensitivity in diabetic rats . | NA | {
"id": "C0022245",
"name": "iso",
"pos": [
110,
113
]
} | {
"id": "C0007412",
"name": "catecholamine",
"pos": [
182,
195
]
} |
therefore a bone marrow biopsy should be included in the diagnostic procedures whenever a toxic lesion is suspected of causing haematological disorders , particularly in all cases of uncertain pancytopenia . | NA | {
"id": "C0018939",
"name": "haematological disorders",
"pos": [
127,
151
]
} | {
"id": "C0030312",
"name": "pancytopenia",
"pos": [
193,
205
]
} |
the tumour was associated with an intrapulmonary typical chondromatous hamartoma in the same lobe but separate from the first lesion . | NA | {
"id": "C0027651",
"name": "tumour",
"pos": [
4,
10
]
} | {
"id": "C0018552",
"name": "hamartoma",
"pos": [
71,
80
]
} |
the lipomatous tumour was primarily an intrapulmonary lipoma but in a few of the numerous sections made minute islands of cartilage and bone were discovered along with a few epithelial-lined clefts . | NA | {
"id": "C0206631",
"name": "lipomatous tumour",
"pos": [
4,
21
]
} | {
"id": "C0023798",
"name": "lipoma",
"pos": [
54,
60
]
} |
in mixed infections in the hima42 host at 32 degrees , lambda + does not complement lambda ( qsr ) 80 for growth and the burst size of the coinfecting lambda + is reduced in comparison to that in a single infection . | NA | {
"id": "C0275524",
"name": "mixed infections",
"pos": [
3,
19
]
} | {
"id": "C0009450",
"name": "infection",
"pos": [
205,
214
]
} |
comparison of the electrophoretic patterns of dna from cells infected at the restrictive temperature with those obtained in wildtype infection revealed that viral dna bands were absent with three additional mutants . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
46,
49
]
} | {
"id": "C0012939",
"name": "viral dna",
"pos": [
157,
166
]
} |
kl3 reactivity was not modified by preincubation of skin sections with lectins showing a selective intercellular labelling of upper layers of epidermis or pemphigus antisera , nor by adsorption of the antibody on np40 soluble proteins of the epidermis . | NA | {
"id": "C0023206",
"name": "lectins",
"pos": [
71,
78
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
226,
234
]
} |
kl3 reactivity was not modified by preincubation of skin sections with lectins showing a selective intercellular labelling of upper layers of epidermis or pemphigus antisera , nor by adsorption of the antibody on np40 soluble proteins of the epidermis . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
165,
173
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
201,
209
]
} |
thus , although a new substance other than insulin is present in the insulin secretory granules of the human pancreatic b-cells , its pathophysiological function remains unclear . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
43,
50
]
} | {
"id": "C0795635",
"name": "insulin",
"pos": [
69,
76
]
} |
the following conclusions can be drawn from this study : 1 ) starvation in the dog leads to a significant and drastic reduction of the circulating levels of igf i , and 2 ) starvation in the dog , as in man , leads to increased circulating gh levels and to an increased gh-secretory capacity possibly brought about by a ... | NA | {
"id": "C0037657",
"name": "igf",
"pos": [
157,
160
]
} | {
"id": "C0021665",
"name": "igf i",
"pos": [
368,
373
]
} |
growth hormone infusion produced a dose-dependent rise of endogenous rat igf from 39 ( without growth hormone ) to 86 microu equivalents/ml ( with 400 mu hgh/day ) as determined by a competitive protein binding assay with a human igf standard . | NA | {
"id": "C0037663",
"name": "growth",
"pos": [
0,
6
]
} | {
"id": "C3714500",
"name": "hgh",
"pos": [
154,
157
]
} |
in rats receiving the two doses of igf i , total serum igf levels rose to 83 and 99 microu equivalents/ml , respectively , in those receiving the igf ii dose the total serum igf level rose to 146 microu equivalents/ml . | NA | {
"id": "C0021665",
"name": "igf i",
"pos": [
35,
40
]
} | {
"id": "C0037657",
"name": "igf",
"pos": [
174,
177
]
} |
in rats receiving the two doses of igf i , total serum igf levels rose to 83 and 99 microu equivalents/ml , respectively , in those receiving the igf ii dose the total serum igf level rose to 146 microu equivalents/ml . | NA | {
"id": "C0021666",
"name": "igf ii",
"pos": [
146,
152
]
} | {
"id": "C0037657",
"name": "igf",
"pos": [
174,
177
]
} |
the rise of endogenous rat igf as well as the infused human igf i and ii caused a widening of the tibial epiphysis and an increase of the [ 3h ] thymidine incorporation into costal cartilage . | NA | {
"id": "C0037657",
"name": "igf",
"pos": [
27,
30
]
} | {
"id": "C0021665",
"name": "igf i",
"pos": [
60,
65
]
} |
when expressed in microu equivalents of the protein binding assay , endogenous rat igf induced by hgh appeared to be relatively more effective than infused human igf i or ii . | NA | {
"id": "C0037657",
"name": "igf",
"pos": [
83,
86
]
} | {
"id": "C0021665",
"name": "igf i",
"pos": [
162,
167
]
} |
the non-selective alpha-adrenoceptor antagonist phentolamine and the selective alpha 1-adrenoceptor antagonist prazosin both inhibited the noradrenaline-induced elevation of radioiodine levels , whereas the alpha 2-adrenoceptor antagonist yohimbine had no such effect , except at a high dose level . | NA | {
"id": "C0034784",
"name": "alpha-adrenoceptor",
"pos": [
18,
36
]
} | {
"id": "C0001638",
"name": "alpha 1-adrenoceptor",
"pos": [
79,
99
]
} |
the non-selective alpha-adrenoceptor antagonist phentolamine and the selective alpha 1-adrenoceptor antagonist prazosin both inhibited the noradrenaline-induced elevation of radioiodine levels , whereas the alpha 2-adrenoceptor antagonist yohimbine had no such effect , except at a high dose level . | NA | {
"id": "C0034784",
"name": "alpha-adrenoceptor",
"pos": [
18,
36
]
} | {
"id": "C0001639",
"name": "alpha",
"pos": [
207,
212
]
} |
effects of small doses of bovine tsh on serum levels of free and total thyroid hormones , their degradation products , and diiodotyrosine . | NA | {
"id": "C0040135",
"name": "thyroid",
"pos": [
71,
78
]
} | {
"id": "C0012344",
"name": "diiodotyrosine",
"pos": [
123,
137
]
} |
we conclude that direct stimulation of the thyroid gland with btsh in small doses leads to consistent increases of thyroid hormones , especially t3 and ft3 , that the response varies between individuals , and that the precursor diiodotyrosine is released together with thyroid hormones . | NA | {
"id": "C0012344",
"name": "diiodotyrosine",
"pos": [
228,
242
]
} | {
"id": "C0040135",
"name": "thyroid",
"pos": [
269,
276
]
} |
no differences were found between the two groups regarding response of glucagon to hypoglycaemia , whereas the epinephrine ( 2-fold ) , norepinephrine ( 2.4-fold ) and cortisol responses were significantly greater in the group with the slow recovery . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
111,
122
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
136,
150
]
} |
in the present study we determined progesterone ( p ) , 17-oh-progesterone ( 17-oh-p ) , androstenedione ( delta 4 ) , dehydroepiandrosterone ( dhea ) and testosterone ( t ) in spermatic venous blood of 34 varicocele patients and of 13 normal subjects . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
35,
47
]
} | {
"id": "C0020387",
"name": "17-oh-progesterone",
"pos": [
56,
74
]
} |
the reduced da turnover in the external layer of the me and the increased na turnover in the pa may indicate an inhibitory dopaminergic mechanism in the me and a facilitatory noradrenergic mechanism in the pa in the regulation of tsh secretion . | NA | {
"id": "C0013030",
"name": "da",
"pos": [
12,
14
]
} | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
123,
135
]
} |
the relative potency of selected agonists in producing inotropic responses ( tmax , t'max ) in the presence of blockers for neuronal and extraneuronal uptakes was found to be as follows : isoprenaline greater than noradrenaline = adrenaline = salbutamol greater than dobutamine . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
214,
227
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
230,
240
]
} |
the selective beta 1- ( practolol ) and beta 2- ( h 35/25 ) blockers reduced inotropic responses to adrenaline ( tmax , t'max ) and noradrenaline ( t'max ) in the auricular strips . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
100,
110
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
132,
145
]
} |
the relative potencies for tmax were : noradrenaline = adrenaline greater than prenalterol greater than dobutamine = salbutamol . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
39,
52
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
55,
65
]
} |
type 1 agents , typified by verapamil , its congeners ( tiapamil and gallopamil ) and diltiazem , prolong atrioventricular nodal conduction and refractoriness with little effect on ventricular or atrial refractoriness . | NA | {
"id": "C0042523",
"name": "verapamil",
"pos": [
28,
37
]
} | {
"id": "C0016986",
"name": "gallopamil",
"pos": [
69,
79
]
} |
these data are consistent with the hypothesis that some patients with chest pain and angiographically normal epicardial coronary arteries have dynamic abnormalities of the small coronary arteries or coronary microcirculation that cause abnormal vasodilator reserve or vasoconstriction , resulting in myocardial ischemia ... | NA | {
"id": "C0008031",
"name": "chest pain",
"pos": [
70,
80
]
} | {
"id": "C0002962",
"name": "angina pectoris",
"pos": [
324,
339
]
} |
in the present study , plasma lipid , lipoprotein lipid , and plasma low-density lipoprotein ( ldl ) apob levels were measured in 66 offspring ( myocardial infarction [ mi ] offspring ) of 24 families in which an index parent had premature coronary artery disease and hyperapobetalipoproteinemia . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
38,
49
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
50,
55
]
} |
univariate analysis revealed that plasma ldl apob and all other lipid and lipoprotein levels except high-density lipoprotein cholesterol were significantly higher in the mi offspring . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
64,
69
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
113,
124
]
} |
groups were comparable in age ( c , 50 +/- 15 years ; bb , 51 +/- 13 years ) , gender ( c , 76 % male ; bb , 56 % male ) , entry functional class ( c , 2.8 +/- 0.8 ; bb , 2.7 +/- 0.7 ) , and left ventricular ejection fraction ( c , 27 +/- 12 % ; bb , 29 +/- 10 % ) . | NA | {
"id": "C0079399",
"name": "gender",
"pos": [
79,
85
]
} | {
"id": "C0086582",
"name": "male",
"pos": [
114,
118
]
} |
we conclude that milk and milk products can be recommended as sources of calcium , that data on the effects of increasing calcium intake from other sources can be applied to milk and that milk may offer an advantage because it does not suppress bone remodeling as severely as calcium carbonate . | NA | {
"id": "C0006675",
"name": "calcium",
"pos": [
73,
80
]
} | {
"id": "C0006681",
"name": "calcium carbonate",
"pos": [
276,
293
]
} |
a morphologic curiosity is presented in a polypoid gastric tumor combined with adenocarcinoma and carcinoid tumor . | NA | {
"id": "C0001418",
"name": "adenocarcinoma",
"pos": [
79,
93
]
} | {
"id": "C0007095",
"name": "carcinoid tumor",
"pos": [
98,
113
]
} |
these data lead to the suggestion that the disassembly and assembly of alphavirus cores might be regulated by a process which could be called receptor-mediated core disassembly , in which acceptors exist for the protein components of viral nucleoproteins in uninfected cells which early in infection bind these proteins ... | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
212,
219
]
} | {
"id": "C0028612",
"name": "nucleoproteins",
"pos": [
473,
487
]
} |
when compared to syngeneic ad2-transformed cells or fibroblasts , the average intensity of fluorescence of ad12-transformed lines was lower , suggesting that the concentration of mhc class i antigen is somewhat lower in ad12-transformed cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
52,
63
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
237,
242
]
} |
sensitivity to killing by both in vivo and in vitro induced allogeneic ctls , however , was not markedly lower with ad12-transformed cells and correlation was not found between tumorigenic potential in vivo and sensitivity to allogeneic t-cell killing in vitro . | NA | {
"id": "C3485979",
"name": "allogeneic ctls",
"pos": [
60,
75
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
133,
138
]
} |
the effects of alfentanil and fentanyl on controlling the haemodynamic responses to laryngoscopy and intubation have been compared . | NA | {
"id": "C0002026",
"name": "alfentanil",
"pos": [
15,
25
]
} | {
"id": "C0015846",
"name": "fentanyl",
"pos": [
30,
38
]
} |
thirty seconds later group 1 received 1 ml/20 kg saline , group 2 received 15 micrograms/kg alfentanil , group 3 received 30 micrograms/kg alfentanil and group 4 received 5 micrograms/kg fentanyl one minute before induction . | NA | {
"id": "C0002026",
"name": "alfentanil",
"pos": [
92,
102
]
} | {
"id": "C0015846",
"name": "fentanyl",
"pos": [
187,
195
]
} |
alfentanil is shown to reduce the cardiovascular responses to laryngoscopy and intubation and the effect appears to have a shorter duration than that of fentanyl . | NA | {
"id": "C0002026",
"name": "alfentanil",
"pos": [
0,
10
]
} | {
"id": "C0015846",
"name": "fentanyl",
"pos": [
153,
161
]
} |
the determination of in-vivo adducts to dna ( the target in most genotoxic effects ) and , especially , to blood proteins , fulfils these criteria , since the demonstration of protein adducts is a relevant measure of formation of the corresponding dna adducts . | NA | {
"id": "C0005832",
"name": "blood",
"pos": [
107,
112
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
176,
183
]
} |
the competitive radioimmunoassay ( ria ) represents a routinely applicable , reproducible and sensitive assay for the detection of defined carcinogen-dna adducts in hydrolysates of cellular dna , in body fluids or in urine . | NA | {
"id": "C0242958",
"name": "carcinogen-dna",
"pos": [
139,
153
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
190,
193
]
} |
by this method , humans with no known occupational exposure to pcb compounds showed pcb levels in serum that were always less than 3 micrograms/l . | NA | {
"id": "C0005580",
"name": "pcb compounds",
"pos": [
63,
76
]
} | {
"id": "C0032447",
"name": "pcb",
"pos": [
84,
87
]
} |
fifty patients with bone primary tumors ( multiple myeloma , osteogenic sarcoma , ewing 's sarcoma , giant cell tumor , and others ) were studied gammagraphically after injecting 555 mbq of 99mtc-mdp . | NA | {
"id": "C0029463",
"name": "osteogenic sarcoma",
"pos": [
61,
79
]
} | {
"id": "C0553580",
"name": "ewing 's sarcoma",
"pos": [
82,
98
]
} |
the effects were often considerable , and they were detected for nearly all of the analytes investigated : albumin , alkaline phosphatase , amylase , bilirubins , calcium ( ii ) , cholesterol , cobalamines , creatininium , creatine kinase , glucose , lactate dehydrogenase , magnesium ( ii ) , protein ( total ) , and so... | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
107,
114
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
294,
301
]
} |
as shown in a previous study , intragastric administration of 16,16-dimethyl prostaglandin e2 ( pge , 100 micrograms/kg t.i.d . ) for three weeks induces growth of the gastric mucosa . | NA | {
"id": "C0012472",
"name": "prostaglandin e2",
"pos": [
77,
93
]
} | {
"id": "C0033559",
"name": "pge",
"pos": [
96,
99
]
} |
complement profiles must be interpreted recognizing that a pattern resembling classical pathway activation can be produced by idiopathic nephrotic syndrome , that hypogammaglobulinemia can reduce clq levels , and that a primary deficiency of factor h or i or both , will secondarily produce subnormal levels of c3 and fa... | NA | {
"id": "C0009498",
"name": "complement",
"pos": [
0,
10
]
} | {
"id": "C0033453",
"name": "factor b",
"pos": [
318,
326
]
} |
the 35s rna of all replication competent helper viruses is divided into three genes encoding the viral structural proteins : the gag ( group-specific antigen ) gene codes for the internal structural proteins , the pol ( polymerase ) gene codes for the enzymes protease , reverse transcriptase and endonuclease and the en... | NA | {
"id": "C0042738",
"name": "viral structural proteins",
"pos": [
97,
122
]
} | {
"id": "C0042711",
"name": "proteins",
"pos": [
354,
362
]
} |
oligopeptides deduced from the sequence of one of the open reading frame in htlv-i were synthesized chemically , and antibodies against these peptides were raised in rabbits . | NA | {
"id": "C0028954",
"name": "oligopeptides",
"pos": [
0,
13
]
} | {
"id": "C0030956",
"name": "peptides",
"pos": [
142,
150
]
} |
human t-cell leukemia virus type i ( htlv-i ) , a family of human retrovirus and the predicted causative agent of human adult t-cell leukemia/lymphoma ( atl ) consists of the gag , pol , env , and px regions ( 1 ) . | NA | {
"id": "C0023493",
"name": "human adult t-cell",
"pos": [
114,
132
]
} | {
"id": "C0023492",
"name": "atl",
"pos": [
153,
156
]
} |
supporting this suggestion , an african green monkey which was naturally infected with stlv was found to have developed t-cell leukemia that was very similar to human atl . | NA | {
"id": "C0023492",
"name": "t-cell",
"pos": [
120,
126
]
} | {
"id": "C0023493",
"name": "human atl",
"pos": [
161,
170
]
} |
the bcaa infusion also prevented a marked fall in the molar ratio of valine , leucine , and isoleucine to phenylalanine and tyrosine . | NA | {
"id": "C0002521",
"name": "bcaa",
"pos": [
4,
8
]
} | {
"id": "C0042285",
"name": "valine",
"pos": [
69,
75
]
} |
the bcaa infusion also prevented a marked fall in the molar ratio of valine , leucine , and isoleucine to phenylalanine and tyrosine . | NA | {
"id": "C0002521",
"name": "bcaa",
"pos": [
4,
8
]
} | {
"id": "C0023401",
"name": "leucine",
"pos": [
95,
102
]
} |
the bcaa infusion also prevented a marked fall in the molar ratio of valine , leucine , and isoleucine to phenylalanine and tyrosine . | NA | {
"id": "C0002521",
"name": "bcaa",
"pos": [
4,
8
]
} | {
"id": "C0022192",
"name": "isoleucine",
"pos": [
92,
102
]
} |
a positive correlation was found between percentage of neutral detergent fiber in the brans and tumor incidences but not between the individual components of cellulose , hemicellulose , or lignin . | NA | {
"id": "C0007648",
"name": "cellulose",
"pos": [
158,
167
]
} | {
"id": "C0023705",
"name": "lignin",
"pos": [
189,
195
]
} |
absence of genotoxicity of the carcinogenic sulfated polysaccharides carrageenan and dextran sulfate in mammalian dna repair and bacterial mutagenicity assays . | NA | {
"id": "C0032594",
"name": "polysaccharides",
"pos": [
53,
68
]
} | {
"id": "C0007289",
"name": "carrageenan",
"pos": [
69,
80
]
} |
the sulfated polysaccharides degraded carrageenan and dextran sulfate sodium were studied for genotoxicity using dna repair tests employing cultured rat hepatocytes or intestinal mucosal cells . | NA | {
"id": "C0032594",
"name": "polysaccharides",
"pos": [
13,
28
]
} | {
"id": "C0007289",
"name": "carrageenan",
"pos": [
38,
49
]
} |
high-fat diet promotes and causes distal shift of experimental rat colonic cancer -- beer and alcohol do not . | NA | {
"id": "C0004922",
"name": "beer",
"pos": [
85,
89
]
} | {
"id": "C0001962",
"name": "alcohol",
"pos": [
94,
101
]
} |
intestinal cancer was induced in inbred male d/a rats by 1,2-dimethylhydrazine , and the interrelationships between a high-fat ( 33.5 % w/w ) diet , beer and alcohol ( 4.8 % v/v ) ingestion , and tumor location and incidence were examined . | NA | {
"id": "C0004922",
"name": "beer",
"pos": [
149,
153
]
} | {
"id": "C0001962",
"name": "alcohol",
"pos": [
158,
165
]
} |
neither alcohol nor beer ingestion affected the incidence of intestinal cancers , but beer was associated with a more distal distribution of small-intestinal cancers in animals on the high-fat diet . | NA | {
"id": "C0001962",
"name": "alcohol",
"pos": [
8,
15
]
} | {
"id": "C0004922",
"name": "beer",
"pos": [
86,
90
]
} |
the amount of coenzyme-unsaturated apotransketolase was assessed by measuring the tpp effect -- determining transketolase activity with and without the addition of tpp in vitro . | NA | {
"id": "C0009235",
"name": "coenzyme",
"pos": [
14,
22
]
} | {
"id": "C0039848",
"name": "tpp",
"pos": [
164,
167
]
} |
all children underwent a standardizet protein meal to evaluate serum gastrin and pepsinogen i response and the pentagastrin test for gastric acid secretion . | NA | {
"id": "C0017151",
"name": "gastrin",
"pos": [
69,
76
]
} | {
"id": "C0030859",
"name": "pentagastrin",
"pos": [
111,
123
]
} |
the study reports on the protein digestibility of five cultivars of common beans ( phaseolus vulgaris ) of different color , tested in young adult human subjects , as the sole dietary protein source . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
25,
32
]
} | {
"id": "C0012177",
"name": "dietary protein",
"pos": [
176,
191
]
} |
out of 3,173 bone marrow biopsies , we found 138 cases ( 4.3 % ) of 'dry tap ' aspirations : 35/218 ( 16 % ) acute leukemias , 44/445 ( 9.8 % ) myeloproliferative syndromes , 29/328 ( 8.8 % ) malignant lymphomas and hodgkin 's diseases , 10/208 ( 4.8 % ) myelomas and 10/74 ( 13.5 % ) metastatic carcinomas . | NA | {
"id": "C0024299",
"name": "malignant lymphomas",
"pos": [
192,
211
]
} | {
"id": "C0019829",
"name": "hodgkin 's diseases",
"pos": [
216,
235
]
} |
during this period , a low level of dna synthesis , distinct from s-phase replication , is found by 3h-thymidine autoradiography to be localized to the sc , as would be expected if repair synthesis involved with crossing over occurred in sc-associated dna . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
21,
22
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
252,
255
]
} |
it is concluded that there is widespread but somewhat indiscriminate transcription on lampbrush loops of a range of repetitive dna sequences , transcription of a wide range of mrnas , continuous transcription of histone and 5s rna , and low or aberrant transcription of ribosomal rna . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
177,
180
]
} | {
"id": "C0035701",
"name": "ribosomal rna",
"pos": [
270,
283
]
} |
immunoprophylaxis against bacillary dysentery by dysentery live vaccine vadizen ( shigella flexneri t32-istrati ) in children collectivities in sv county . | NA | {
"id": "C1527298",
"name": "bacillary dysentery",
"pos": [
26,
45
]
} | {
"id": "C0013369",
"name": "dysentery",
"pos": [
49,
58
]
} |
adrenaline ( a ) - and noradrenaline ( n ) -cells in juxtacortical and central areas of adrenal medullas of nonoperated , sham-operated , and pinealectomized male rats ( n = 125 ) were investigated by quantitative electron and light microscopy . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
0,
10
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
23,
36
]
} |
a study of the frequencies of various hla-b antigens in both groups of patients , in regard to a control group of piemontese population , in relation to the intensity of association ( relative risk ) and to the statistical importance of frequencies , shows only a possible protective effect of the hla-b18 phenotype ( li... | NA | {
"id": "C0019737",
"name": "hla-b antigens",
"pos": [
38,
52
]
} | {
"id": "C0062821",
"name": "hla-b18",
"pos": [
298,
305
]
} |
effects of exogenous adrenaline and noradrenaline on vascular postsynaptic alpha 1- and alpha 2-adrenoceptors in man . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
21,
31
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
36,
49
]
} |
the effects of adrenaline and noradrenaline on vascular postsynaptic alpha 1- and alpha 2-adrenoceptors were investigated in six healthy volunteers . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
15,
25
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
30,
43
]
} |
the vasoconstrictive effect of adrenaline and of noradrenaline was significantly reduced by doxazosin and by yohimbine , and , to a greater extent , by the combination of doxazosin and yohimbine . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
31,
41
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
49,
62
]
} |
it is concluded that exogenous adrenaline and noradrenaline produce vasoconstriction in the vasculature of the human forearm by stimulation of both postsynaptic alpha 1- and alpha 2-adrenoceptors . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
31,
41
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
46,
59
]
} |
arterial and venous plasma noradrenaline in recumbent mild hypertensives , and in normotensives with one adrenal gland , increased significantly during infusion of adrenaline to achieve levels similar to those seen during mental arithmetic stress . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
27,
40
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
164,
174
]
} |
although decreased noradrenaline clearance has not been excluded as an explanation of increased plasma levels , these results are consistent with the hypothesis that physiological concentrations of adrenaline are capable of facilitating noradrenaline release in man . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
22,
32
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
237,
250
]
} |
initial physiological and pharmacological studies suggest that plasma chromogranin a varies with the state of endogenous exocytotic sympathoadrenal activity , but the plasma chromogranin changes are modest and the ultimate source of the plasma immunoreactivity ( e.g . adrenomedullary versus sympathetic neuronal ) has n... | NA | {
"id": "C0055633",
"name": "chromogranin a",
"pos": [
70,
84
]
} | {
"id": "C0008586",
"name": "chromogranin",
"pos": [
174,
186
]
} |
a significantly smaller augmentation of the natriuretic response to anf was produced by equipressor does of norepinephrine and epinephrine , suggesting that the potentiation by ang ii and avp were not entirely due to increased mean arterial pressure ( map ) . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
108,
122
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
127,
138
]
} |
lesions of the ventrolateral medulla coinciding with the a1 noradrenaline cell group , in either the rabbit or the rat , cause hypertension and bradycardia accompanied by 50-fold increases in plasma vasopressin and adrenaline and a two-to-four-fold increase in plasma noradrenaline . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
63,
73
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
268,
281
]
} |
such endothelial cell removal resulted in an increase in pressor responses to angiotensin ii , epinephrine , norepinephrine and serotonin . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
95,
106
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
109,
123
]
} |
blood pressure ( bp ) , plasma levels of norepinephrine ( ne ) and epinephrine , the chronotropic effect of isoproterenol , and the relationship between variations in bp and concomitant plasma ne levels obtained during ne infusion were studied under control conditions and after 10 days of dietary potassium supplementat... | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
44,
55
]
} | {
"id": "C0028351",
"name": "ne",
"pos": [
562,
564
]
} |
exchangeable sodium , blood volume , plasma norepinephrine , epinephrine , renin levels , and pressor responses to infused norepinephrine or angiotensin ii were assessed in 10 patients with essential hypertension on placebo , following six to eight weeks of monotherapy with nifedipine , 3 x 10-20 mg/day , and after six... | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
44,
58
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
126,
137
]
} |
the calcium-ejecting adenosine triphosphatase ( atpase ) was inhibited by vanadate and the influx of 45ca2-into the cells measured . | NA | {
"id": "C0001476",
"name": "calcium",
"pos": [
4,
11
]
} | {
"id": "C0001473",
"name": "atpase",
"pos": [
48,
54
]
} |
it was demonstrated that baclofen , a gaba-ergic agent , exerted a sedative effect in rats with tolerance to the sedative action of oxazepam and nitrazepam induced by administration of these drugs during several weeks . | NA | {
"id": "C0004609",
"name": "baclofen",
"pos": [
25,
33
]
} | {
"id": "C0016904",
"name": "gaba",
"pos": [
38,
42
]
} |
it was found that the main component of neutral lipids was cholesterol ( 48 % ) followed by triglycerides ( 24 % ) , cholesterol esters ( 16 % ) and free fatty acids ( 12 % ) . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
59,
70
]
} | {
"id": "C0008387",
"name": "cholesterol esters",
"pos": [
117,
135
]
} |
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