text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
[ subcutaneous connective tissue reaction in rats after implantation of restorative dental alloys . duracast , idealoy , chromium-cobalt and gold alloys ] . | NA | {
"id": "C0002154",
"name": "alloys",
"pos": [
91,
97
]
} | {
"id": "C0018027",
"name": "gold alloys",
"pos": [
141,
152
]
} |
the following amino acids dissolved in ringer-locke solution were tested : glycine , glutamic acid , serine , alanine , aspartic acid , gamma aminobutyric acid , leucine , and peptides : vasopressin and oxytocin . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
14,
25
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
75,
82
]
} |
the following amino acids dissolved in ringer-locke solution were tested : glycine , glutamic acid , serine , alanine , aspartic acid , gamma aminobutyric acid , leucine , and peptides : vasopressin and oxytocin . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
14,
25
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
110,
117
]
} |
an inversion of the effects of adrenaline and noradrenaline on the rat heart was observed , and an enhancement of the vasoconstrictor effect of these substances . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
31,
41
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
46,
59
]
} |
the effects of bile acids ( deoxycholic , cholic and dehydrocholic ) were studied on the action of certain autonomic system drugs ( isoprenaline , adrenaline , noradrenaline and acetylcholine ) . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
147,
157
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
160,
173
]
} |
it was found that bile acids decreased the relaxing effect of isoprenaline and caused inversion of the action of adrenaline and noradrenaline on the intestine . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
113,
123
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
128,
141
]
} |
two cases of gonadal dysgenesis and stigmata of turner 's syndrome with ring chromosome x are described . | NA | {
"id": "C0018051",
"name": "gonadal dysgenesis",
"pos": [
13,
31
]
} | {
"id": "C0041408",
"name": "turner 's syndrome",
"pos": [
48,
66
]
} |
the radiosensitizing efficacy of sr-2508 , a new 2-nitroimidazole , which is less neurotoxic than misonidazole ( miso ) was studied using transplantable mammary carcinoma of c3h/he mice . | NA | {
"id": "C0028179",
"name": "nitroimidazole",
"pos": [
51,
65
]
} | {
"id": "C0026218",
"name": "misonidazole",
"pos": [
98,
110
]
} |
hydroxyethyl-methacrylate ( gma ) -embedded renal biopsies containing amyloid were tested by the indirect immunoperoxidase method with antibodies against the following purified amyloid fibril proteins : aa , three different a lambda preparations , ak and af . | NA | {
"id": "C0002716",
"name": "amyloid",
"pos": [
70,
77
]
} | {
"id": "C1456454",
"name": "amyloid",
"pos": [
177,
184
]
} |
the consequence of these events is the production of an mrna encoding the precursor of a novel neuropeptide , referred to as cgrp , in the brain and an mrna encoding the precursor to calcitonin in the thyroidal c cells . | NA | {
"id": "C0027895",
"name": "neuropeptide",
"pos": [
95,
107
]
} | {
"id": "C0006668",
"name": "calcitonin",
"pos": [
183,
193
]
} |
despite the sizable excretion of ions and sweat , the athlete 's large caloric intake and renal conservation of sodium minimize the threat of chronic dehydration or electrolyte deficits , or both . | NA | {
"id": "C0022023",
"name": "ions",
"pos": [
33,
37
]
} | {
"id": "C0013832",
"name": "electrolyte",
"pos": [
165,
176
]
} |
it has been suggested by several authors that so called 'primary ' pulmonary hypertension may have an 'autoimmune ' basis because of the clinical association of this condition with raynaud 's phenomenon , polyarthritis and its not infrequent association with other conditions affecting connective tissue , such as progre... | NA | {
"id": "C0004364",
"name": "autoimmune",
"pos": [
103,
113
]
} | {
"id": "C0024141",
"name": "systemic lupus erythematosus",
"pos": [
357,
385
]
} |
the anti-inflammatory effects of desferrioxamine were supported by a decrease in concentration of the acute phase reactant alpha 1 glycoprotein . | NA | {
"id": "C0001347",
"name": "acute phase reactant",
"pos": [
102,
122
]
} | {
"id": "C0029297",
"name": "alpha 1 glycoprotein",
"pos": [
123,
143
]
} |
in order to evaluate the utility of enzyme galleries in the differential diagnosis of human lymphoid malignancies , we have determined ninety-three cytosolic enzymic activities in four human lymphomas ( hodgkin 's disease , nodular esclerosing type ; immunoblastic sarcoma , b-cell type ; plasmacytoid lymphocytic lympho... | NA | {
"id": "C0024299",
"name": "lymphomas",
"pos": [
191,
200
]
} | {
"id": "C0019829",
"name": "hodgkin 's disease",
"pos": [
203,
221
]
} |
however , there is preliminary evidence that the protective activity of these opsonic antibodies may be augmented by toxin-neutralizing antibodies directed toward the lipid a moiety of endotoxin and exotoxin a . | NA | {
"id": "C0040549",
"name": "toxin",
"pos": [
117,
122
]
} | {
"id": "C0015309",
"name": "exotoxin",
"pos": [
199,
207
]
} |
decreased binding to the s12 protein ( often termed the p10 protein in references to streptomycin ) , decreased active transport , and enzyme-mediated modification are the major mechanisms responsible for resistance to aminoglycosides . | NA | {
"id": "C0038425",
"name": "streptomycin",
"pos": [
85,
97
]
} | {
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
219,
234
]
} |
seventy-four patients whose therapy could be evaluated were randomly assigned to therapy with either cefsulodin at various dosages or an aminoglycoside ( gentamicin , tobramycin , or amikacin ) . | NA | {
"id": "C0002556",
"name": "aminoglycoside",
"pos": [
137,
151
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
154,
164
]
} |
rates of bacteriologic cure for 30 sites of infection were 64 % ( 7/11 ) for skin and skin-structure infections treated with cefsulodin or reference antibiotics ; | NA | {
"id": "C0009450",
"name": "infection",
"pos": [
44,
53
]
} | {
"id": "C0037278",
"name": "skin",
"pos": [
86,
90
]
} |
potent new antimicrobial chemotherapy has been developed , with most new agents of the beta-lactam and aminoglycoside classes . | NA | {
"id": "C1136254",
"name": "antimicrobial",
"pos": [
11,
24
]
} | {
"id": "C0002556",
"name": "aminoglycoside",
"pos": [
103,
117
]
} |
development of monoclonal antibodies and new methods for preparing hyperimmune globulins has produced forms of intervention that must be tested by clinical trials , but not all patients may benefit from augmentation of circulating antibodies to p. aeruginosa . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
15,
36
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
231,
241
]
} |
possible connections of inflammatory states with tumors are discussed regarding the results with ferritin bearing lymphocytes together with other findings about the role of cell bound iron binding proteins in conditions of tumor and inflammation . | NA | {
"id": "C0015879",
"name": "ferritin",
"pos": [
97,
105
]
} | {
"id": "C1135611",
"name": "iron binding proteins",
"pos": [
184,
205
]
} |
m-mode contrast echocardiography with peripheral venous injections was performed in 73 patients with interatrial communications : 48 ( group 1 ) had a hemodynamically significant atrial septal defect ( asd ) , 19 ( group 2 ) had a patent foramen ovale ( pfo ) without clinical or oxymetric evidence of a shunt . | NA | {
"id": "C0018817",
"name": "atrial septal defect",
"pos": [
179,
199
]
} | {
"id": "C0016522",
"name": "patent foramen ovale",
"pos": [
231,
251
]
} |
in 57 patients ( 39 asd , 17 pfo , 1 group 3 ) contrast studies were also performed during the valsalva maneuver . | NA | {
"id": "C0018817",
"name": "asd",
"pos": [
20,
23
]
} | {
"id": "C0016522",
"name": "pfo",
"pos": [
29,
32
]
} |
valsalva provocation resulted in increased contrast shunting in 19 , led to new mitral funnel opacification in 9 and improved the sensitivity of contrast echocardiography by 9 and 26 % in asd and pfo cases respectively . | NA | {
"id": "C0018817",
"name": "asd",
"pos": [
188,
191
]
} | {
"id": "C0016522",
"name": "pfo",
"pos": [
196,
199
]
} |
however the distinction between a hemodynamically significant asd and pulmonary arteriovenous fistulas , certain venous anomalies or a patent foramen ovale may be difficult or even impossible by contrast echocardiographic criteria alone . | NA | {
"id": "C0018817",
"name": "asd",
"pos": [
62,
65
]
} | {
"id": "C0016522",
"name": "patent foramen ovale",
"pos": [
135,
155
]
} |
resting two-dimensional contrast echocardiograms were recorded in 57 patients including 34 with asd , 18 with pfo and 5 from group 3 . | NA | {
"id": "C0018817",
"name": "asd",
"pos": [
96,
99
]
} | {
"id": "C0016522",
"name": "pfo",
"pos": [
110,
113
]
} |
enalapril is administered as the ethyl ester of the potent angiotensin converting enzyme ( ace ) inhibitor enalaprilat . | NA | {
"id": "C0014025",
"name": "enalapril",
"pos": [
0,
9
]
} | {
"id": "C0014027",
"name": "enalaprilat",
"pos": [
107,
118
]
} |
similarly under conditions of salt loading and salt depletion , a biphasic saluretic response is seen which parallels the excretory maxima for unchanged enalapril ( 1-2 h ) and enalaprilat ( 4-8 h ) suggesting direct interference by the drug moieties with tubular nacl reabsorption . | NA | {
"id": "C0014025",
"name": "enalapril",
"pos": [
153,
162
]
} | {
"id": "C0014027",
"name": "enalaprilat",
"pos": [
177,
188
]
} |
during the period of maximal enalapril action , uricosuria and phosphaturia are seen , supporting a direct action of enalaprilat on proximal tubular handling of these anions . | NA | {
"id": "C0014025",
"name": "enalapril",
"pos": [
29,
38
]
} | {
"id": "C0014027",
"name": "enalaprilat",
"pos": [
117,
128
]
} |
therefore this study was conducted to investigate the hemodynamic response ( blood pressure , cardiac rate ) and the plasma catecholamine ( adrenaline , noradrenaline ) release induced by a standardized psychomental stress model ( sonic confuser ) . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
140,
150
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
153,
166
]
} |
an apparent dissociation of protein-rna complex occurred due to the covalent attachment of anionic phosphate groups onto yeast protein molecules . | NA | {
"id": "C0003075",
"name": "anionic",
"pos": [
91,
98
]
} | {
"id": "C0031603",
"name": "phosphate",
"pos": [
99,
108
]
} |
igg insulin antibody levels were identical after human insulin treatment ( 5.7 +/- 0.4 micrograms/l ) compared to pork insulin treatment ( 5.9 +/- 0.5 micrograms/l ) . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
4,
11
]
} | {
"id": "C0795635",
"name": "human insulin",
"pos": [
49,
62
]
} |
fifty-eight of a consecutive series of 75 pregnancies in women with insulin-dependent diabetes went into the third trimester . | NA | {
"id": "C0032961",
"name": "pregnancies",
"pos": [
42,
53
]
} | {
"id": "C0032981",
"name": "third trimester",
"pos": [
109,
124
]
} |
plasma c-peptide declined after each insulin was administered , and was significantly lower between 2 and 7 hours after porcine insulin . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
37,
44
]
} | {
"id": "C0724601",
"name": "porcine",
"pos": [
120,
127
]
} |
in contrast to typical giant cell tumor of bone , a rare case of malignant giant cell tumor showed aneuploid cell lines indicating the malignant nature of the tumor . | NA | {
"id": "C0206638",
"name": "giant cell tumor of bone",
"pos": [
23,
47
]
} | {
"id": "C0017525",
"name": "of",
"pos": [
152,
154
]
} |
monolayer cultures of mouse pancreatic beta cells were used to study protein composition , the extent and nature of rna and protein synthesis , and the kinetics of insulin precursors synthesis , precursor processing , and the release of nascent insulin . | NA | {
"id": "C0033362",
"name": "insulin precursors",
"pos": [
164,
182
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
245,
252
]
} |
at least 15 proteins ( mol . wt . 66,000 to less than 14,000 ) were synthesized , including insulin precursors and insulin . | NA | {
"id": "C0033362",
"name": "insulin precursors",
"pos": [
92,
110
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
115,
122
]
} |
this reduction in radioactivity was partly due to the processing of insulin precursors into insulin and partly due to the release of proinsulin into the medium along with newly synthesized insulin . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
133,
143
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
189,
196
]
} |
the 50 sequences , belonging to seven protein lineages related by gene duplication ( calmodulin itself , troponin-c , alkali and regulatory light chains of myosin , parvalbumin , intestinal calcium-binding protein , and glial s-100 phenylalanine-rich protein ) , came from a wide range of eukaryotic taxa and yielded a d... | NA | {
"id": "C0077400",
"name": "troponin-c",
"pos": [
105,
115
]
} | {
"id": "C0006732",
"name": "calcium-binding protein",
"pos": [
190,
213
]
} |
sudden phase advances ( or delays ) by several hours were observed in the rhythms of continuously recorded rectal temperature and urinary excretion rates ( 4-hr collection intervals ) of adrenaline , noradrenaline and aldosterone the first day after sleep-wake displacement . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
187,
197
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
200,
213
]
} |
pretreatment of rats with isoprenaline ( 50 mg/kg , i.p . ) decreased and catecholamine depletion ( reserpine plus inhibition of tyrosine-hydroxylase ) increased bmax-values in crude membranes . | NA | {
"id": "C0022245",
"name": "isoprenaline",
"pos": [
26,
38
]
} | {
"id": "C0007412",
"name": "catecholamine",
"pos": [
74,
87
]
} |
a circannual rhythm was detected using the circadian means of each subject at each season as input for the population mean cosinor in the women for acth , c-peptide , dhea-s , fsh , lh , progesterone , 17-oh progesterone and tsh . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
187,
199
]
} | {
"id": "C0020387",
"name": "17-oh progesterone",
"pos": [
202,
220
]
} |
the kinetics of protective antibodies was similar to that of neutralizing antibodies , but with higher titers . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
27,
37
]
} | {
"id": "C0475463",
"name": "neutralizing antibodies",
"pos": [
61,
84
]
} |
liposomes containing either pilocarpine hydrochloride or pilocarpine free base were prepared by the sonication method . | NA | {
"id": "C0770456",
"name": "pilocarpine hydrochloride",
"pos": [
28,
53
]
} | {
"id": "C0031923",
"name": "pilocarpine",
"pos": [
57,
68
]
} |
for an identical liposomal composition , the encapsulation capacity and the drug content of the liposomes were drastically higher for pilocarpine hydrochloride than for pilocarpine free base . | NA | {
"id": "C0770456",
"name": "pilocarpine hydrochloride",
"pos": [
134,
159
]
} | {
"id": "C0031923",
"name": "pilocarpine",
"pos": [
169,
180
]
} |
spleen cells from autoimmune-prone mice and peripheral blood mononuclear cells from patients with systemic lupus erythematosus ( sle ) , however , are severely deficient in their capacity to both produce and respond to il 2 following a challenge with mitogenic lectins . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
7,
12
]
} | {
"id": "C1321301",
"name": "peripheral blood mononuclear cells",
"pos": [
44,
78
]
} |
anti-poly [ d ( g-br5c ) ] igg binding sites are found in all tested covalently closed circular natural dnas ( form i ) at their extracted negative superhelical densities , but not in any of the corresponding relaxed form ii or linear form iii dnas . | NA | {
"id": "C0012925",
"name": "circular",
"pos": [
87,
95
]
} | {
"id": "C0012854",
"name": "dnas",
"pos": [
244,
248
]
} |
higher order oligomeric species , indicative of two or more left-handed segments per dna molecule are formed in reactions of anti-poly [ d ( g-br5c ) ] igg with m13 rf i dna but not with sv40 , pbr322 , or phi x174 dnas . | NA | {
"id": "C0043442",
"name": "left-handed",
"pos": [
60,
71
]
} | {
"id": "C0012854",
"name": "dnas",
"pos": [
215,
219
]
} |
taken together , these studies confirm our earlier sugar-puckering assignments and demonstrate that iodine covalently bound to the c5 position on uridine or cytosine does not alter the basic sugar-phosphate geometry or the mode of ethidium intercalation in these model studies . | NA | {
"id": "C0007004",
"name": "sugar",
"pos": [
51,
56
]
} | {
"id": "C0038655",
"name": "sugar-phosphate",
"pos": [
191,
206
]
} |
the basic structural feature of the sugar-phosphate chains accompanying dimethylproflavine intercalation in both structures is the mixed sugar puckering pattern : c3 ' endo ( 3'-5 ' ) c2 ' endo . | NA | {
"id": "C0038655",
"name": "sugar-phosphate",
"pos": [
36,
51
]
} | {
"id": "C0007004",
"name": "sugar",
"pos": [
137,
142
]
} |
the alkali-ion binding properties of two natural depsipeptide ion carriers , enniatin b ( enb ) and valinomycin ( vm ) , are examined and compared by the empirical force field method . | NA | {
"id": "C0796678",
"name": "depsipeptide",
"pos": [
49,
61
]
} | {
"id": "C0042287",
"name": "valinomycin",
"pos": [
100,
111
]
} |
to further characterize this in vitro system as a potential screening assay for potential teratogens , tumor promoters and reproductive toxicants , a series of common solvents as well as other chemicals representing eight different functional groups , i.e. , alcohols with straight or side chains , glycols , ketones , e... | NA | {
"id": "C0001975",
"name": "alcohols",
"pos": [
259,
267
]
} | {
"id": "C0017951",
"name": "glycols",
"pos": [
299,
306
]
} |
tris ( 1-aziridinyl ) phosphine oxide ( tepa ) and tris ( 1-aziridinyl ) phosphine sulfide ( thio-tepa ) induced base pair mutations in the ames mutagenic assay . | NA | {
"id": "C0039533",
"name": "tepa",
"pos": [
40,
44
]
} | {
"id": "C0039871",
"name": "thio-tepa",
"pos": [
93,
102
]
} |
hydroxyurea , deoxyadenosine , pyridine-2-carboxaldehyde thiosemicarbazone , pyrazoloimidazole , 3,5-diamino-1,2,4 triazole ( guanazole ) , 3,4,5-trihydroxy benzohydroxamic acid and 3,4-dihydroxy benzohydroxamic acid were examined for their effects on cellular dntp pools , dna excision repair , dna replication and deox... | NA | {
"id": "C0040880",
"name": "triazole",
"pos": [
115,
123
]
} | {
"id": "C0018316",
"name": "guanazole",
"pos": [
126,
135
]
} |
hydroxyurea , deoxyadenosine , pyridine-2-carboxaldehyde thiosemicarbazone , pyrazoloimidazole , 3,5-diamino-1,2,4 triazole ( guanazole ) , 3,4,5-trihydroxy benzohydroxamic acid and 3,4-dihydroxy benzohydroxamic acid were examined for their effects on cellular dntp pools , dna excision repair , dna replication and deox... | NA | {
"id": "C0007634",
"name": "cellular",
"pos": [
252,
260
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
356,
367
]
} |
coefficients of correlation between oligonucleotide frequencies overall and those in specific segments vary as follows : primary strands of individual coding sequences greater than 0.9 greater than lambda dna greater than noncoding , non-rna greater than phi x174 dna greater than complementary strands greater than rna ... | NA | {
"id": "C0887909",
"name": "noncoding",
"pos": [
222,
231
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
316,
319
]
} |
the results of a monte carlo simulation of the hydration of uracil and thymine molecules , their stacked dimers and hydrogen-bonded base pairs are presented . | NA | {
"id": "C0041917",
"name": "uracil",
"pos": [
60,
66
]
} | {
"id": "C0040087",
"name": "thymine",
"pos": [
71,
78
]
} |
it has been shown that the stacking interactions of uracil and thymine molecules in water arise mainly due to the increase in the water-water interaction during the transition from monomers to dimer . | NA | {
"id": "C0041917",
"name": "uracil",
"pos": [
52,
58
]
} | {
"id": "C0040087",
"name": "thymine",
"pos": [
63,
70
]
} |
reductive methylation of the lysyl residues in the fd gene 5 dna-binding protein : cd and 13c nmr results on the modified protein . | NA | {
"id": "C0012940",
"name": "dna-binding",
"pos": [
61,
72
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
122,
129
]
} |
monte carlo computer simulations were performed on dilute aqueous solutions of thymine , cytosine , uracil , adenine , guanine , the dimethyl phosphate anion in the gauche-gauche conformation and a ribose and deoxyribose derivative . | NA | {
"id": "C0040087",
"name": "thymine",
"pos": [
79,
86
]
} | {
"id": "C0041917",
"name": "uracil",
"pos": [
100,
106
]
} |
the results enable to comment on two current problems related to the hydration of nucleic acids : a ) the theory of dickerson and coworkers on the role of water in the relative stability of the a and b form of dna and b ) the idea of water bridges and filaments emerging from the computer simulation results on the hydra... | NA | {
"id": "C0028606",
"name": "nucleic acids",
"pos": [
82,
95
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
328,
331
]
} |
the results enable to comment on two current problems related to the hydration of nucleic acids : a ) the theory of dickerson and coworkers on the role of water in the relative stability of the a and b form of dna and b ) the idea of water bridges and filaments emerging from the computer simulation results on the hydra... | NA | {
"id": "C0919262",
"name": "b form",
"pos": [
200,
206
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
328,
331
]
} |
for the refinement of the potential function parameters calculations of ice lattice energy , potential energy and configuration of small clusters consisting of water and nucleic acid base molecules as well as monte carlo simulation of liquid water were performed . | NA | {
"id": "C0020746",
"name": "ice",
"pos": [
72,
75
]
} | {
"id": "C0043047",
"name": "water",
"pos": [
242,
247
]
} |
sites of preferential hydration of five nucleic bases - uracil , thymine , cytosine , guanine and adenine as well as of 6,6,9-trimethyladenine were found . | NA | {
"id": "C0041917",
"name": "uracil",
"pos": [
56,
62
]
} | {
"id": "C0040087",
"name": "thymine",
"pos": [
65,
72
]
} |
the configuration of the copper complex of the glycopeptide bleomycin , cublm , is presumed to be pyramidal square planar from a previous x-ray structural determination of a fragment of cupric bleomycin . | NA | {
"id": "C0017953",
"name": "glycopeptide",
"pos": [
47,
59
]
} | {
"id": "C0005740",
"name": "bleomycin",
"pos": [
193,
202
]
} |
considered in physiological terms , we suggest that in addition to the amount of i-a antigen present on antigen-presenting cells , turnover and shedding of i-a antigens may be important for the stimulation of an immune response by allogeneic cells and in allowing a cell with receptors for foreign antigen ( x ) as well ... | NA | {
"id": "C3485979",
"name": "allogeneic cells",
"pos": [
231,
247
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
377,
382
]
} |
immunoglobulin allotyping carried out on patients with ankylosing spondylitis , psoriatic arthritis and psoriasis alone showed increase in the phenotype g1m ( 1,2,3 ) ; g3m ( 5,11,21 ) in the psoriasis patients in general ( p less than 0.05 ) . | NA | {
"id": "C0003872",
"name": "psoriatic arthritis",
"pos": [
80,
99
]
} | {
"id": "C0033860",
"name": "psoriasis",
"pos": [
192,
201
]
} |
the precise antigenic conformations recognised by these antibodies have been defined by inhibition studies with monosaccharides , disaccharides and synthetic blood group oligosaccharides . | NA | {
"id": "C0012611",
"name": "disaccharides",
"pos": [
130,
143
]
} | {
"id": "C0028959",
"name": "oligosaccharides",
"pos": [
170,
186
]
} |
this variation is caused by sequence changes in the genes coding these antigens and this review summarizes recent information on the structure of the ha and na , the way in which these glycoproteins vary and the effects of the changes on the antigenic properties of the virus . | NA | {
"id": "C0003320",
"name": "antigens",
"pos": [
71,
79
]
} | {
"id": "C0003342",
"name": "antigenic",
"pos": [
242,
251
]
} |
peptidoglycan peptide-interacting proteins ( ppips ) which include the penicillin-binding proteins ( pbps ) are bacterial enzymes which interact with beta-lactams ( including penicillins and cephalosporins ) and/or acyl-d-ala-d-ala analogues of a non-beta-lactam structure . | NA | {
"id": "C0030842",
"name": "penicillins",
"pos": [
175,
186
]
} | {
"id": "C0282215",
"name": "beta-lactam",
"pos": [
251,
262
]
} |
six hundred and six visits satisfied criteria for inclusion in one of the following critical care categories : trauma , poisonings , burns , spinal cord injuries , behavioral disorders , cardiovascular illness , and a general category designated `` '' medical . '' '' | NA | {
"id": "C0043251",
"name": "trauma",
"pos": [
111,
117
]
} | {
"id": "C0006434",
"name": "burns",
"pos": [
133,
138
]
} |
studies of the rickettsial diseases at the south african institute for medical research : epidemic louse-borne typhus fever . | NA | {
"id": "C0035585",
"name": "rickettsial diseases",
"pos": [
15,
35
]
} | {
"id": "C0041473",
"name": "epidemic louse-borne typhus",
"pos": [
90,
117
]
} |
mean excitation energies for stopping powers in various materials composed of elements hydrogen through argon . | NA | {
"id": "C0013879",
"name": "elements",
"pos": [
78,
86
]
} | {
"id": "C0020275",
"name": "hydrogen",
"pos": [
87,
95
]
} |
tentative identifications include saturated and unsaturated aliphatic hydrocarbons , substituted polycyclic aromatics , nitriles , amines , pyrroles , pyrazines , pyridines , pyrimidines , and the purine , adenine . | NA | {
"id": "C0034140",
"name": "purine",
"pos": [
197,
203
]
} | {
"id": "C0001407",
"name": "adenine",
"pos": [
206,
213
]
} |
this technique together with measures of the total phospholipid , the phospholipid fatty acid , the muramic acid and the hydroxy fatty acids of the lipopolysaccharide lipid a of the gram-negative bacteria makes it possible to describe the community structure environmental samples . | NA | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
148,
166
]
} | {
"id": "C0023767",
"name": "lipid a",
"pos": [
167,
174
]
} |
potential derived point charge model study of electrostatic interaction energies in some complexes of water with uracil , thymine , and cytosine . | NA | {
"id": "C0041917",
"name": "uracil",
"pos": [
113,
119
]
} | {
"id": "C0040087",
"name": "thymine",
"pos": [
122,
129
]
} |
potential derived ( pd ) point charges and segmental multipole moments are calculated for water , uracil , thymine , and cytosine using sto-3g quality wave functions . | NA | {
"id": "C0041917",
"name": "uracil",
"pos": [
98,
104
]
} | {
"id": "C0040087",
"name": "thymine",
"pos": [
107,
114
]
} |
as initial models of amino acids , z was chosen to be h and nh2 , corresponding to acetic acid and glycine , respectively , xo4hn+1 = h3po4 represents a phosphate group , while si ( oh ) 4 describes an edge tetrahedral site of a clay mineral . | NA | {
"id": "C0002520",
"name": "amino",
"pos": [
21,
26
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
99,
106
]
} |
neuropeptide y , which is a cotransmitter with norepinephrine and epinephrine , is found in sympathetic neurons that are closely associated with and presumably innervate the juxtagolmerular cells . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
47,
61
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
66,
77
]
} |
there was considerable range in the absolute yields of amino acids , but the yields relative to glycine ( or alpha-amino-n-butyric acid ) were more uniform . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
55,
66
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
96,
103
]
} |
both the loss of oxygen and the presently observed enrichment of the deuterium-to-hydrogen ratio are most easily explained if oceans of liquid water were initially present . | NA | {
"id": "C0011744",
"name": "deuterium",
"pos": [
69,
78
]
} | {
"id": "C0020275",
"name": "hydrogen",
"pos": [
82,
90
]
} |
recoveries of added cyanocobalamin or hydroxocobalamin were better than 95 % and results correlated significantly with those obtained using a microbiological assay ( poteriochromonas malhamensis ) . | NA | {
"id": "C0042845",
"name": "cyanocobalamin",
"pos": [
20,
34
]
} | {
"id": "C0020316",
"name": "hydroxocobalamin",
"pos": [
38,
54
]
} |
all staphylococci were sensitive to tetracycline ( 30 microg ) , novobiocin ( 1.6 microg ) , nafcillin ( 30 microg ) , methicillin ( 10 microg ) and cephalothin ( 30 microg ) and variable numbers of each species were sensitive to penicillin ( 2 iu ) and streptomycin ( 10 microg ) . | NA | {
"id": "C0027324",
"name": "nafcillin",
"pos": [
93,
102
]
} | {
"id": "C0030842",
"name": "penicillin",
"pos": [
230,
240
]
} |
findings indicate variable gender and age differences in the feelings experienced by children aged 5 , 6 , 7 , and 8 towards male and female parents . | NA | {
"id": "C0079399",
"name": "gender",
"pos": [
27,
33
]
} | {
"id": "C0086582",
"name": "male",
"pos": [
136,
140
]
} |
starvation produced marked reductions ( approximately 30 % ) in the circulating concentrations of retinol binding protein and prealbumin but did not significantly affect the plasma concentration of immunoglobulins ( igg , iga , igm ) acute phase reactants ( orosomucoid , haptoglobin , alpha ( 1 ) antitrypsin ) , albumi... | NA | {
"id": "C0001347",
"name": "acute phase reactants",
"pos": [
234,
255
]
} | {
"id": "C0029297",
"name": "orosomucoid",
"pos": [
258,
269
]
} |
starvation produced marked reductions ( approximately 30 % ) in the circulating concentrations of retinol binding protein and prealbumin but did not significantly affect the plasma concentration of immunoglobulins ( igg , iga , igm ) acute phase reactants ( orosomucoid , haptoglobin , alpha ( 1 ) antitrypsin ) , albumi... | NA | {
"id": "C0001347",
"name": "acute phase reactants",
"pos": [
234,
255
]
} | {
"id": "C0018595",
"name": "haptoglobin",
"pos": [
272,
283
]
} |
starvation produced marked reductions ( approximately 30 % ) in the circulating concentrations of retinol binding protein and prealbumin but did not significantly affect the plasma concentration of immunoglobulins ( igg , iga , igm ) acute phase reactants ( orosomucoid , haptoglobin , alpha ( 1 ) antitrypsin ) , albumi... | NA | {
"id": "C0001347",
"name": "acute phase reactants",
"pos": [
234,
255
]
} | {
"id": "C0002191",
"name": "alpha ( 1",
"pos": [
286,
295
]
} |
a hormonal influence on gluconeogenesis after stomach resection was sought by correlating the degree of carbon flux from alanine to glucose with the plasma levels of insulin , glucagon , adrenaline , noradrenaline and cortisol and with the urinary excretion of catecholamines , ( nor ) metanephrines and cortisol . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
187,
197
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
200,
213
]
} |
a hormonal influence on gluconeogenesis after stomach resection was sought by correlating the degree of carbon flux from alanine to glucose with the plasma levels of insulin , glucagon , adrenaline , noradrenaline and cortisol and with the urinary excretion of catecholamines , ( nor ) metanephrines and cortisol . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
187,
197
]
} | {
"id": "C0025562",
"name": "metanephrines",
"pos": [
286,
299
]
} |
during the radiation treatment period these amino acids plus valine , proline , serine and glycine were exceptionally high . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
44,
55
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
91,
98
]
} |
four infusions were formulations of amino acids with dextrose of varying branched chain amino acid content ( 100 % , 53 % , 35 % and 16 % branched chain to total amino acids ) . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
36,
47
]
} | {
"id": "C0002521",
"name": "branched chain",
"pos": [
138,
152
]
} |
protein balance also occurred with 100 % bcaa , in association with marked increases in underlying protein synthesis and breakdown and with this infusion there were marked elevations in the plasma branched chain amino acids and depression of the other plasma amino acids . | NA | {
"id": "C0002521",
"name": "branched chain amino acids",
"pos": [
197,
223
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
259,
270
]
} |
in patients who did not receive glucose during operation blood glucose and plasma insulin concentrations did not change but lipolysis was induced as indicated by the increase of serum free fatty acids concentration . | NA | {
"id": "C0017725",
"name": "glucose",
"pos": [
32,
39
]
} | {
"id": "C0005802",
"name": "glucose",
"pos": [
63,
70
]
} |
nutritional assessment was carried out by evaluating the extent of recent weight loss , the weight for height index and by measuring the arm muscle circumference ( amc ) , triceps skinfold thickness ( tsf ) , the creatinine-height index ( chi ) and serum albumin and prealbumin concentrations . | NA | {
"id": "C0036773",
"name": "serum albumin",
"pos": [
249,
262
]
} | {
"id": "C0032923",
"name": "prealbumin",
"pos": [
267,
277
]
} |
lipids , lipoproteins and fatty acid composition in obese adolescents undergoing a very low calorie diet . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
0,
6
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
9,
21
]
} |
the spectral assignations of all the main resonances in the 13c nuclear magnetic resonance spectra in dmso-d6 or d2o are presented and reviewed for ten of the principal tetracyclines in therapeutic use : tetracycline , chlortetracycline , 6-demethylchlortetracycline , minocycline , oxytetracycline , methacycline , mecl... | NA | {
"id": "C0039651",
"name": "tetracyclines",
"pos": [
169,
182
]
} | {
"id": "C0008293",
"name": "chlortetracycline",
"pos": [
249,
266
]
} |
the spectral assignations of all the main resonances in the 13c nuclear magnetic resonance spectra in dmso-d6 or d2o are presented and reviewed for ten of the principal tetracyclines in therapeutic use : tetracycline , chlortetracycline , 6-demethylchlortetracycline , minocycline , oxytetracycline , methacycline , mecl... | NA | {
"id": "C0039651",
"name": "tetracyclines",
"pos": [
169,
182
]
} | {
"id": "C0011276",
"name": "demethylchlortetracycline",
"pos": [
241,
266
]
} |
the spectral assignations of all the main resonances in the 13c nuclear magnetic resonance spectra in dmso-d6 or d2o are presented and reviewed for ten of the principal tetracyclines in therapeutic use : tetracycline , chlortetracycline , 6-demethylchlortetracycline , minocycline , oxytetracycline , methacycline , mecl... | NA | {
"id": "C0039651",
"name": "tetracyclines",
"pos": [
169,
182
]
} | {
"id": "C0026187",
"name": "minocycline",
"pos": [
269,
280
]
} |
the spectral assignations of all the main resonances in the 13c nuclear magnetic resonance spectra in dmso-d6 or d2o are presented and reviewed for ten of the principal tetracyclines in therapeutic use : tetracycline , chlortetracycline , 6-demethylchlortetracycline , minocycline , oxytetracycline , methacycline , mecl... | NA | {
"id": "C0039651",
"name": "tetracyclines",
"pos": [
169,
182
]
} | {
"id": "C0030092",
"name": "oxytetracycline",
"pos": [
283,
298
]
} |
the spectral assignations of all the main resonances in the 13c nuclear magnetic resonance spectra in dmso-d6 or d2o are presented and reviewed for ten of the principal tetracyclines in therapeutic use : tetracycline , chlortetracycline , 6-demethylchlortetracycline , minocycline , oxytetracycline , methacycline , mecl... | NA | {
"id": "C0039651",
"name": "tetracyclines",
"pos": [
169,
182
]
} | {
"id": "C0025603",
"name": "methacycline",
"pos": [
301,
313
]
} |
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