text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
the best antibiotics against anaerobic sinusitis are clindamycin and tetracycline in general administration , and lincomycin , thiamfenicol and tetracycline for local application . | NA | {
"id": "C0008947",
"name": "clindamycin",
"pos": [
53,
64
]
} | {
"id": "C0023726",
"name": "lincomycin",
"pos": [
114,
124
]
} |
nine healthy male subjects were given beverage containing ethanol ( 1.5 g/kg ) or beverage alone per os in a randomized cross-over study and plasma acth , fsh , gh , lh and tsh were measured by specific radioimmunoassays up to 15 h and the urinary levels of adrenaline and noradrenaline by fluorometry . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
258,
268
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
273,
286
]
} |
during the whole experiment there were no significant differences in the plasma levels of acth , fsh and tsh or in the urinary levels of adrenaline and noradrenaline between ethanol treated and control subjects . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
137,
147
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
152,
165
]
} |
competition between palmitate and acyl-coa for binding sites on protein ( e.g. , albumine added to the mitochondrial suspensions ) was indicated by stimulation of carnitine acylation by palmitate with palmityl-coa added as substrate in the absence of atp . | NA | {
"id": "C0001374",
"name": "acyl-coa",
"pos": [
34,
42
]
} | {
"id": "C0030239",
"name": "palmityl-coa",
"pos": [
201,
213
]
} |
cholesterol , cholesteryl esters , triglycerides and fatty acids as major neutral lipids and phospholipids were examined in quantitative analysis . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
0,
11
]
} | {
"id": "C0008387",
"name": "cholesteryl esters",
"pos": [
14,
32
]
} |
combining these modified methods and colorimetry for determination of cholesterol cholesteryl esters and phospholipids , the author established a micromethod for determining the major neutral lipids and phospholipids by thin-layer chromatography . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
70,
81
]
} | {
"id": "C0008387",
"name": "cholesteryl esters",
"pos": [
82,
100
]
} |
in diabetes , amyloidosis , tubular nephrosis ( necrosis ) glomerulonephritis , lupus nephritis and endemic benign nephropathy there were 14-66 % polynuclear granulocytes . | NA | {
"id": "C0027720",
"name": "nephrosis",
"pos": [
36,
45
]
} | {
"id": "C0022658",
"name": "nephropathy",
"pos": [
115,
126
]
} |
the antibody group ( m ) shared by all 3 bymv isolates was present in the fvm1 antiserum in a level only a little higher than the second antibody group ( a ) . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
4,
12
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
79,
88
]
} |
antisera to tpm3 and tpm11 isolates showed only a low titre of m antibody , while the second antibody group ( n ) reached titres from 512 to 1024 . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
0,
8
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
93,
101
]
} |
the stimulatory effects of diethylstilbestrol and diethylstilbestrol diphosphate on the reticuloendothelial cells of the rat spleen . | NA | {
"id": "C0012203",
"name": "diethylstilbestrol",
"pos": [
27,
45
]
} | {
"id": "C0060692",
"name": "reticuloendothelial cells",
"pos": [
88,
113
]
} |
when eels are transferred from fresh to salf water , thus increasing active outward transport of chloride across the gill , the thiocyanate-inhibited atpase of gill microsomes does not change , though the activities of succinic dehydrogenase and na-k-atpase in gill homogenates are augmented . | NA | {
"id": "C0001473",
"name": "atpase",
"pos": [
150,
156
]
} | {
"id": "C0001479",
"name": "na-k-atpase",
"pos": [
246,
257
]
} |
the thiocyanate-inhibited atpase of homogenates of outer renal medulla does not differ from that of renal cortex , in contrast to na-k-atpase which is higher in renal medulla than in cortex . | NA | {
"id": "C0001473",
"name": "atpase",
"pos": [
26,
32
]
} | {
"id": "C0001479",
"name": "na-k-atpase",
"pos": [
130,
141
]
} |
chickens genetically selected for high incidence of articular gout and hyperuricemia were used to determine the site of defective uric acid ( ua ) transport in gout . | NA | {
"id": "C0003868",
"name": "articular gout",
"pos": [
52,
66
]
} | {
"id": "C0018099",
"name": "gout",
"pos": [
160,
164
]
} |
within 2 h after glucose administration to fasting rats the incorporation of radioactive lactate into blood glucose and liver glycogen is decreased . | NA | {
"id": "C0017725",
"name": "glucose",
"pos": [
17,
24
]
} | {
"id": "C0005802",
"name": "blood glucose",
"pos": [
102,
115
]
} |
experiments were carried out with the isolated perfused liver of the overnight-starved rat to study the control of the conversion of the essential amino acid threonine to glucose and urea from the point of view of its conservation when in short supply . | NA | {
"id": "C0002525",
"name": "essential",
"pos": [
137,
146
]
} | {
"id": "C0040005",
"name": "threonine",
"pos": [
158,
167
]
} |
least often the tumor extends entirely extrabronchially ( case ii ) presenting as a parahilar parenchymal asymptomatic nodule , simulating a granuloma , hamartoma , arteriovenous malformation or a neoplastic nodule . | NA | {
"id": "C0027651",
"name": "tumor",
"pos": [
16,
21
]
} | {
"id": "C0018552",
"name": "hamartoma",
"pos": [
153,
162
]
} |
there is ample evidence from this retrospective comparison to indicate that emphysematous cholecystitis does merit clinical distinction apart from acute cholecystitis . | NA | {
"id": "C0521610",
"name": "emphysematous cholecystitis",
"pos": [
76,
103
]
} | {
"id": "C0149520",
"name": "acute",
"pos": [
147,
152
]
} |
gangrene is a common feature of the pathologic process , and thus it is not surprising that the diagnosis of emphysematous cholecystitis implies a risk of gallbladder perforation that is five times that expected from ordinary acute cholecystitis . | NA | {
"id": "C0521610",
"name": "emphysematous cholecystitis",
"pos": [
109,
136
]
} | {
"id": "C0149520",
"name": "acute",
"pos": [
226,
231
]
} |
the effect of single and repeated topical application of adrenaline on the intraocular pressure and pupil in the rabbit eye was studied using a 2 % adrenaline borate and a commercial preparation of 2 % adrenaline hydrochloride . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
57,
67
]
} | {
"id": "C0059447",
"name": "adrenaline borate",
"pos": [
148,
165
]
} |
the effect of single and repeated topical application of adrenaline on the intraocular pressure and pupil in the rabbit eye was studied using a 2 % adrenaline borate and a commercial preparation of 2 % adrenaline hydrochloride . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
57,
67
]
} | {
"id": "C0001636",
"name": "adrenaline hydrochloride",
"pos": [
202,
226
]
} |
the excretion of adrenaline and noradrenalin was significantly lower during anaesthesia as compared with the initial value , suggesting a depression of sympathoadrenal system . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
17,
27
]
} | {
"id": "C0028351",
"name": "noradrenalin",
"pos": [
32,
44
]
} |
the postoperative amount of adrenaline and especially noradrenaline increased markedly , when anaesthesia worn off , postoperative shivering started , and surgical wounds caused pain . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
28,
38
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
54,
67
]
} |
the early fibroblast in characterized by long cytoplasmic processes which contain numerous cytofilaments , and by the presence of collagen fibers in the vicinity of the cell . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
10,
20
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
169,
173
]
} |
when sem micrographs of primitive streak stage embryos were examined in stereo , it was found that cells which had been invaginating at the time of fixation were similar in shape to fibroblasts migrating in vitro . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
99,
104
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
182,
193
]
} |
when trehalose is injected via parenteral pathway into animals lacking kidney trehalase ( rat ) , more than 75 per cent of this disaccharide is eliminated in urine . | NA | {
"id": "C0040815",
"name": "trehalose",
"pos": [
5,
14
]
} | {
"id": "C0012611",
"name": "disaccharide",
"pos": [
128,
140
]
} |
a disorder in clofibrate mechanism , detected by gaseous chromatography in the form of an abnormal peak at c15 ( clofibric acid ) is found 12 hours or more after the last ingestion of the drug in certain cases . | NA | {
"id": "C0009002",
"name": "clofibrate",
"pos": [
14,
24
]
} | {
"id": "C0009003",
"name": "clofibric acid",
"pos": [
113,
127
]
} |
if no mannose is found in the polysaccharides when they are synthesised in non-proliferation conditions and if mannans are found in yeast broth , it may be thought , as suggested by humphrey , that mannose would come from those mannans . | NA | {
"id": "C0032594",
"name": "polysaccharides",
"pos": [
30,
45
]
} | {
"id": "C0024727",
"name": "mannans",
"pos": [
228,
235
]
} |
in this paper , we describe a strain of s. aureus resistant to gentamycin-kanamycin-tobramycin-sisomycin , and experiments which suggest that the genetic determinant of these resistance characters is plasmid borne . | NA | {
"id": "C0017436",
"name": "gentamycin",
"pos": [
63,
73
]
} | {
"id": "C0037209",
"name": "sisomycin",
"pos": [
95,
104
]
} |
[ metabolism of paraffinic and naphthalenic hydrocarbons in higher animals . ii . accumulation and mobilization in rats ] . | NA | {
"id": "C0030415",
"name": "paraffinic",
"pos": [
16,
26
]
} | {
"id": "C0020242",
"name": "hydrocarbons",
"pos": [
44,
56
]
} |
we will thus have a better knowledge of this very peculiar disease of the otic capsule , hat is otospongiosis , characterized by its two phases : a first lytic phase provoked by an enzymatic factor , then a second rebuilding phase according to a pseudo haversian process . | NA | {
"id": "C0013447",
"name": "of",
"pos": [
37,
39
]
} | {
"id": "C0029899",
"name": "otospongiosis",
"pos": [
96,
109
]
} |
in 1969-1973 , acute yersiniosis was diagnosed in 30 cases of erythema nodosum ( en ) , in 6 cases of en and simultaneous erythema multiforme ( em ) , in one case of en and erythema figuratum , in one case of em , and in one case of drug eruption-like exanthema , respectively . | NA | {
"id": "C0014743",
"name": "en",
"pos": [
81,
83
]
} | {
"id": "C0011609",
"name": "drug",
"pos": [
233,
237
]
} |
in 1969-1973 , acute yersiniosis was diagnosed in 30 cases of erythema nodosum ( en ) , in 6 cases of en and simultaneous erythema multiforme ( em ) , in one case of en and erythema figuratum , in one case of em , and in one case of drug eruption-like exanthema , respectively . | NA | {
"id": "C0041834",
"name": "erythema",
"pos": [
62,
70
]
} | {
"id": "C0014742",
"name": "em",
"pos": [
258,
260
]
} |
general toxic and myeloinhibitory effects of some antitumor antibiotics , such as rubomycin , olivomycin , bruneomycin and karminomycin administered intraperitoneally in a single ld50 to mice were studied . | NA | {
"id": "C0011015",
"name": "rubomycin",
"pos": [
82,
91
]
} | {
"id": "C0007308",
"name": "karminomycin",
"pos": [
123,
135
]
} |
it was found that the general toxicity of bruneomycin and karminomycin was almost the same and 5 to 8 times higher than that of rubomycin and olivomycin . | NA | {
"id": "C0007308",
"name": "karminomycin",
"pos": [
58,
70
]
} | {
"id": "C0011015",
"name": "rubomycin",
"pos": [
128,
137
]
} |
the gentamycin sulfate complex and the components of gentamycin had the same activity levels , antibacterial spectrum and diffusion capacity . | NA | {
"id": "C0546866",
"name": "gentamycin",
"pos": [
4,
14
]
} | {
"id": "C0017436",
"name": "gentamycin",
"pos": [
53,
63
]
} |
correlation between the binding level of penicillins with human serum albumin and their effect on the spectrum of epr of the spin-label attached to albumin was observed only with the use of a hydrophobic probe ( radical iii ) . | NA | {
"id": "C0304925",
"name": "human serum albumin",
"pos": [
58,
77
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
148,
155
]
} |
lactulose , a non-absorbable disaccharide , was investigated as an alternative therapy for shigella infection on the hypothesis that the short-chain fatty acids ( inhibitory to shigella ) resulting from metabolism of lactulose by normal colonic flora would diminish shigella excretion . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
203,
213
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
275,
284
]
} |
the results of the microbiological assays demonstrate that the stability of the antibiotics in the frozen plasma decreases in the following order : oxytetracycline > cephalexin , streptomycin , erythromycin > demeclocycline > ampicillin , amoxycillin > penicillin g , cephaloridine , rolitetracycline , and tetracycline ... | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
226,
236
]
} | {
"id": "C0002645",
"name": "amoxycillin",
"pos": [
239,
250
]
} |
the results of the microbiological assays demonstrate that the stability of the antibiotics in the frozen plasma decreases in the following order : oxytetracycline > cephalexin , streptomycin , erythromycin > demeclocycline > ampicillin , amoxycillin > penicillin g , cephaloridine , rolitetracycline , and tetracycline ... | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
226,
236
]
} | {
"id": "C0030827",
"name": "penicillin g",
"pos": [
253,
265
]
} |
the antiviral activity of 5-methoxymethyl-2'-deoxyuridine ( mmudr ) was compared with that of 5-iodo-2'-deoxyuridine ( iudr ) , cytosine arabinoside ( ara-c ) , and adenine arabinoside ( ara-a ) . | NA | {
"id": "C0011535",
"name": "deoxyuridine",
"pos": [
45,
57
]
} | {
"id": "C0020811",
"name": "iudr",
"pos": [
119,
123
]
} |
combination of mmudr with either iudr , ara-a , or ara-c gave an enhanced antiviral effect , suggesting that the mechanism of action of mmudr is different from that of the other three drugs . | NA | {
"id": "C0020811",
"name": "iudr",
"pos": [
33,
37
]
} | {
"id": "C0011535",
"name": "mmudr",
"pos": [
136,
141
]
} |
antiviral indexes were calculated for each compound and were found to be > 250 , 80 , 40 , and 8 for mmudr , iudr , ara-a , and ara-c , respectively . | NA | {
"id": "C0011535",
"name": "mmudr",
"pos": [
101,
106
]
} | {
"id": "C0020811",
"name": "iudr",
"pos": [
109,
113
]
} |
sisomicin was found to be more active on a weight basis than gentamicin against pseudomonas sp. , klebsiella sp. , and indole-positive proteus . | NA | {
"id": "C0037209",
"name": "sisomicin",
"pos": [
0,
9
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
61,
71
]
} |
gentamicin was more active than sisomicin against escherichia coli , serratia sp. , enterobacter sp. , and proteus mirabilis . | NA | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
0,
10
]
} | {
"id": "C0037209",
"name": "sisomicin",
"pos": [
32,
41
]
} |
a mould which was isolated from a solution of paracetamol was identified as a penicillium species and was found to possess the ability to utilise a series of substituted acetanilides , including paracetamol ( 4-hydroxyacetanilide ) , phenacetin ( 4-ethoxyacetanilide ) and metacetamol ( 3-hydroxyacetanilide ) as sole ca... | NA | {
"id": "C0000974",
"name": "acetanilides",
"pos": [
170,
182
]
} | {
"id": "C0000970",
"name": "4-hydroxyacetanilide",
"pos": [
209,
229
]
} |
a mould which was isolated from a solution of paracetamol was identified as a penicillium species and was found to possess the ability to utilise a series of substituted acetanilides , including paracetamol ( 4-hydroxyacetanilide ) , phenacetin ( 4-ethoxyacetanilide ) and metacetamol ( 3-hydroxyacetanilide ) as sole ca... | NA | {
"id": "C0000974",
"name": "acetanilides",
"pos": [
170,
182
]
} | {
"id": "C0031364",
"name": "phenacetin",
"pos": [
234,
244
]
} |
nadh , like nad , glutamic acid , glutamine , arginine , ornithine , proline , aspartic acid and alpha-ketoglutarate exhibited no inhibition . | NA | {
"id": "C0061472",
"name": "glutamic acid",
"pos": [
18,
31
]
} | {
"id": "C0017797",
"name": "glutamine",
"pos": [
34,
43
]
} |
the major classes of rna ( rrna , mrna , trna ) start to be synthesized simultaneously in the zoospore of allomyces soon after the onset of germination . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
21,
24
]
} | {
"id": "C0035701",
"name": "rrna",
"pos": [
27,
31
]
} |
minute amounts of epinephrine or norepinephrine alter the behavior of 'rage ' cats ( prepared by ventromedial hypothalamotomy ) when these substances are focally instilled into both amygdalae via chronic brain cannulae capped with a silastic membrane . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
18,
29
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
33,
47
]
} |
in atopic dermatitis of patients , who acquired the dermatitis as adults , the proportion was lower , although it was possible to examine the tissues of only three such patients . | NA | {
"id": "C0011615",
"name": "atopic",
"pos": [
3,
9
]
} | {
"id": "C0011603",
"name": "dermatitis",
"pos": [
52,
62
]
} |
the mortality caused by barbiturate poisoning in mice is reduced by the combined action of the dna pyrimidines thymine and 5-hydroxymethylcytosine ( 5-hmc ) and the structurally related vitamins , pyridoxal , nicotinamide and thiamine , given intraperitoneally . | NA | {
"id": "C0034289",
"name": "pyrimidines",
"pos": [
99,
110
]
} | {
"id": "C0039840",
"name": "thiamine",
"pos": [
226,
234
]
} |
the effects of various agents on the specific tissue binding of 3h-naloxone and 3h-naltrexone were examined . | NA | {
"id": "C0027358",
"name": "naloxone",
"pos": [
67,
75
]
} | {
"id": "C0027360",
"name": "naltrexone",
"pos": [
83,
93
]
} |
the binding of naloxone or naltrexone was not significantly altered by beta-adrenergic blockers , agents which block the effects of acetylcholine , serotonin and histamine at the receptor level , and a number of other drugs . | NA | {
"id": "C0027358",
"name": "naloxone",
"pos": [
15,
23
]
} | {
"id": "C0027360",
"name": "naltrexone",
"pos": [
27,
37
]
} |
[ selection of discriminatory biochemical variables for the diagnosis of intra-hepatic cholestasis , extra-hepatic cholestasis and liver cancer ( author 's transl ) ] . | NA | {
"id": "C0008372",
"name": "intra-hepatic cholestasis",
"pos": [
73,
98
]
} | {
"id": "C0008370",
"name": "cholestasis",
"pos": [
115,
126
]
} |
the intestinal absorption of five amino acids studied ( l-lysine , l-glycine , l-leucine and l-tyrosine ) and one dipeptide ( glycylglycine ) was significantly inhibited by the deconjugated bile salt , sodium deoxycholate , in rats in vivo . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
34,
45
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
132,
139
]
} |
the intestinal absorption of five amino acids studied ( l-lysine , l-glycine , l-leucine and l-tyrosine ) and one dipeptide ( glycylglycine ) was significantly inhibited by the deconjugated bile salt , sodium deoxycholate , in rats in vivo . | NA | {
"id": "C0012512",
"name": "dipeptide",
"pos": [
114,
123
]
} | {
"id": "C0017984",
"name": "glycylglycine",
"pos": [
126,
139
]
} |
complications in the form of torsion , rupture which haemoperitoneum or haemorrhage into the cyst were common . | NA | {
"id": "C0019065",
"name": "haemoperitoneum",
"pos": [
53,
68
]
} | {
"id": "C0019080",
"name": "haemorrhage",
"pos": [
72,
83
]
} |
in addition to use of this finding in aviator selection , it is felt that studies of this trait , as it relates to an ability to reconcile conflict and to motion sickness insusceptibility , should be conducted . | NA | {
"id": "C0037088",
"name": "finding",
"pos": [
27,
34
]
} | {
"id": "C0026603",
"name": "motion sickness",
"pos": [
155,
170
]
} |
there was no additive effect of these three calcitonin peptides whereas parathyroid hormone added to salmon calcitonin increased adenylate cyclase activity , thus showing that both hormones bound to different membrane receptors . | NA | {
"id": "C0006668",
"name": "calcitonin",
"pos": [
44,
54
]
} | {
"id": "C0073994",
"name": "salmon",
"pos": [
101,
107
]
} |
cleavage of 45s rna to 32s rna also occurs , but there was no evidence for the accumulation of mature or immature rrna in the nucleus . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
16,
19
]
} | {
"id": "C0035701",
"name": "rrna",
"pos": [
114,
118
]
} |
by using a gentle procedure for fractionating nuclei into their major structurally different components [ j. r. tata & b. baker ( 1974 ) exp . cell res . 83 . 111-124 ] , it was found that the hormone-induced increase in the total amount of newly made rna was associated with a 2-10-fold increase in the poly ( a ) conte... | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
252,
255
]
} | {
"id": "C0035700",
"name": "nuclear rna",
"pos": [
326,
337
]
} |
when the poly ( a ) content of nuclear rna was determined by hybridization to poly [ 3h ] ( u ) or specific binding to oligo ( dt ) -cellulose , most of the increase ( 10-fold ) in poly ( a ) content of newly synthesized rna was associated with the euchromatin fractions , whereas the increase was less marked in the oth... | NA | {
"id": "C0035700",
"name": "nuclear rna",
"pos": [
31,
42
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
221,
224
]
} |
resolution of nuclear rna into poly ( a ) -poor and poly ( a ) -rich rna species by chromatography on oligo ( dt ) -cellulose , followed by polyacrylamide-gel electrophoresis with sodium dodecyl sulphate or in the pressence of 99 % formamide , revealed that the hormone caused a preferential enhancement of high-molecula... | NA | {
"id": "C0035700",
"name": "nuclear rna",
"pos": [
14,
25
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
388,
391
]
} |
resolution of nuclear rna into poly ( a ) -poor and poly ( a ) -rich rna species by chromatography on oligo ( dt ) -cellulose , followed by polyacrylamide-gel electrophoresis with sodium dodecyl sulphate or in the pressence of 99 % formamide , revealed that the hormone caused a preferential enhancement of high-molecula... | NA | {
"id": "C0035700",
"name": "nuclear rna",
"pos": [
14,
25
]
} | {
"id": "C0035695",
"name": "heterogeneous nuclear rna",
"pos": [
366,
391
]
} |
alanine and glutamine were the predominant amino acids released into the circulation in this preparation . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
0,
7
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
43,
54
]
} |
cycloheximide added at maximum steroid production caused a rapid decrease in testosterone synthesis which followed first-order kinetics ( half-life 13 min ) , thus indicating that the protein regulator ( s ) has a short half-life . | NA | {
"id": "C0022702",
"name": "kinetics",
"pos": [
127,
135
]
} | {
"id": "C0018517",
"name": "half-life",
"pos": [
220,
229
]
} |
conversion of glutamate into proline or hydroxyproline in cell-layer protein was not affected significantly by the number of population doublings . | NA | {
"id": "C0033382",
"name": "proline",
"pos": [
29,
36
]
} | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
40,
54
]
} |
comparison of the turn-off patterns for some proteins and the known polycistronic organization of the structural genes for these proteins suggests that a major cause of the unequal turn-off was the degradation of mrna molecules for the ribosomal proteins from the 5'-end toward the 3'-end . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
45,
53
]
} | {
"id": "C0035552",
"name": "ribosomal proteins",
"pos": [
236,
254
]
} |
the relative transcriptional activities of genes coding for ribosomal rna ( rrna ) and ribosomal proteins ( r-proteins ) at a steady-state growth rates ranging from 0.65 to 2.1 doublings/h can be estimated from previous measurements of the synthesis rates of stable and unstable rna ( pato & von meyenburg , 1970 ; nierl... | NA | {
"id": "C0035701",
"name": "ribosomal rna",
"pos": [
60,
73
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
279,
282
]
} |
5-propyl-2-thiouracil and 6-propyl-2-thiouracil , both known to prevent deiodination in vivo , greatly decreased the deiodiantion activity of rat liver homogenate . | NA | {
"id": "C0039957",
"name": "thiouracil",
"pos": [
11,
21
]
} | {
"id": "C0033511",
"name": "6-propyl-2-thiouracil",
"pos": [
26,
47
]
} |
plasma-membrane fractions fi and fii isolated from bovine corpus luteum by discontinuous sucrose-density-gradient centrifugation , at sucrose-density interfaces of 1.14/1.16 and 1.16/1.18 respectively , contained membrane-associated protein kinases that phosphorylated both the structural proteins of membranes as well a... | NA | {
"id": "C0025252",
"name": "membrane",
"pos": [
7,
15
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
340,
347
]
} |
a microsomal fraction rich in na+ , k+-atpase ( sodium-plus-potassium ion-dependent adenosine triphosphatase ) and the corresponding k+-dependent p-nitrophenyl phosphatase from the rectal salt gland of the spiny dogfish was solubilized by treatment with deoxycholate at high ionic strength . | NA | {
"id": "C0001473",
"name": "atpase",
"pos": [
39,
45
]
} | {
"id": "C0001479",
"name": "sodium",
"pos": [
48,
54
]
} |
none of the major cnbr peptides of troponin t isolated formed a complex with troponin c on electrophoresis at ph 8.6 . | NA | {
"id": "C0077404",
"name": "troponin t",
"pos": [
35,
45
]
} | {
"id": "C0041199",
"name": "complex",
"pos": [
64,
71
]
} |
removal of cations by a chelating resin ( chelex 100 ) produced as inactive enzyme that could be reactiviated by the addition of ca2+ ions at concentrations as low as 1mum . | NA | {
"id": "C0007447",
"name": "cations",
"pos": [
11,
18
]
} | {
"id": "C0022023",
"name": "ions",
"pos": [
152,
156
]
} |
on a molar basis , the inhibitory activity for the several glycosaminoglycans studied was : heparin greater than chondroitin sulphate greater than hyaluronic acid . | NA | {
"id": "C0017973",
"name": "glycosaminoglycans",
"pos": [
59,
77
]
} | {
"id": "C0019134",
"name": "heparin",
"pos": [
92,
99
]
} |
one coincided with brush border enzymes such as alkaline phosphatase , disaccharidases and l-leucine b-naphthylamidase , whereas the other was coincident with the major peak of ( na++k+ ) -stimulated atpase ( adenosine triphosphatase ) , which has been thought to be concentrated in the basolateral plasma membranes of t... | NA | {
"id": "C0001479",
"name": "na",
"pos": [
103,
105
]
} | {
"id": "C0001473",
"name": "adenosine triphosphatase",
"pos": [
209,
233
]
} |
alumina chromatography of the kidney and intestinal extracts demonstrated that retinol and retinyl palmitate are the principal forms of vitamin a present . | NA | {
"id": "C0073115",
"name": "retinyl palmitate",
"pos": [
91,
108
]
} | {
"id": "C0042839",
"name": "vitamin a",
"pos": [
136,
145
]
} |
thus , an increased secretion of pituitary prolactin in rats appears to be an important enhancing endocrinic condition in carcinogenesis of the male mammary gland . | NA | {
"id": "C0032002",
"name": "pituitary",
"pos": [
33,
42
]
} | {
"id": "C0014130",
"name": "endocrinic condition",
"pos": [
98,
118
]
} |
the sensitivity of na , k-atpase to acetylcholine and its analogues decreased as follows : acetylcholine , propionylcholine butyrylcholine , arecoline , carbacholine , choline . | NA | {
"id": "C0006945",
"name": "carbacholine",
"pos": [
153,
165
]
} | {
"id": "C0008405",
"name": "choline",
"pos": [
168,
175
]
} |
[ comparison of histone-like proteins from blue-green algae with ribosomal basic proteins of alga and wheat germ histones ] . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
29,
37
]
} | {
"id": "C0035552",
"name": "ribosomal",
"pos": [
65,
74
]
} |
content of basic amino acids ( arginine being prevailing in algae protein ) is quite identical in histone-like algae proteins and in wheat germs histones , while the content of acid amino acids is considerably higher in algae . | NA | {
"id": "C0301714",
"name": "basic amino acids",
"pos": [
11,
28
]
} | {
"id": "C0003765",
"name": "arginine",
"pos": [
31,
39
]
} |
content of basic amino acids ( arginine being prevailing in algae protein ) is quite identical in histone-like algae proteins and in wheat germs histones , while the content of acid amino acids is considerably higher in algae . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
66,
73
]
} | {
"id": "C0600607",
"name": "algae proteins",
"pos": [
111,
125
]
} |
the protease studied most efficiently hydrolyzed caseine and hemoglobin , in a less degree -- human serum albumin and fibrinogen and almost did not attack egg albumin . | NA | {
"id": "C0304925",
"name": "human serum albumin",
"pos": [
94,
113
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
159,
166
]
} |
syntheses of gamma-crystallin and subunits of alpha-crystallin were shown to start at the first minute of the incybation . | NA | {
"id": "C0017030",
"name": "gamma-crystallin",
"pos": [
13,
29
]
} | {
"id": "C0010422",
"name": "crystallin",
"pos": [
52,
62
]
} |
the trypsin inhibitor from soybean is found to suppress considerably the incorporation of 14c-glycine , 14c-lysine and 14c-methionine into crystal trypsin and not to affect the incorporation of labelled amino acids into chomotrypsin , papain and carboxypeptidase . | NA | {
"id": "C0017890",
"name": "glycine",
"pos": [
94,
101
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
203,
214
]
} |
nucleic acids and nucleoproteins were precipitated with protamine sulphate , the proteins were fractioned with ( nh4 ) 2so4 , by gel filtration through sephadex g-25 followed by chromatography on deae-cellulose using stepways elution by changing the ph-values . | NA | {
"id": "C0028612",
"name": "nucleoproteins",
"pos": [
18,
32
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
81,
89
]
} |
53-fold purified creatine kinase is isolated from beef heart mitochondria by phosphate buffer extraction followed by chromatography on deae-cellulose and km-cellulose and preparative electrophoresis in phosphate buffer density gradient . | NA | {
"id": "C0011050",
"name": "deae-cellulose",
"pos": [
135,
149
]
} | {
"id": "C0007648",
"name": "cellulose",
"pos": [
157,
166
]
} |
a method of isolating dna from pea chloroplasts ( ch-dna ) in cscl density gradient is described . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
0,
1
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
53,
56
]
} |
the properties of haemoglobin oxygen transport were compared under three different conditions : red cell in its natural medium , i.e . plasma ( whole blood ) , washed red cell and haemoglobin a , the former suspended , the latter solved in an iso-osmotic tris buffer . | NA | {
"id": "C0019046",
"name": "haemoglobin",
"pos": [
18,
29
]
} | {
"id": "C0019016",
"name": "haemoglobin a",
"pos": [
180,
193
]
} |
the relationship between arterial oxygen pressure and pulmonary arterial pressure is the same in patients with cwp and obstructive airway disease as in patients with chronic obstructive airway disease but without cwp . | NA | {
"id": "C0600260",
"name": "obstructive airway disease",
"pos": [
119,
145
]
} | {
"id": "C0024117",
"name": "chronic obstructive",
"pos": [
166,
185
]
} |
4 atropine selectively antagonized beta-alanine depolarizations of primary afferents and blocked beta-alanine and glycine hyperpolarizations of motoneurones . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
40,
47
]
} | {
"id": "C0000392",
"name": "beta-alanine",
"pos": [
97,
109
]
} |
those produced by adrenaline and noradrenaline were stronger than those due to histamine , acetylcholine and carbachol and were abolished by an alpha-adrenoceptor blocking agent , phentolamine . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
18,
28
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
33,
46
]
} |
1 pyometra is a disorder of the uterus usually associated with bacterial infection plus obstruction . | NA | {
"id": "C0034215",
"name": "pyometra",
"pos": [
2,
10
]
} | {
"id": "C0042131",
"name": "disorder of",
"pos": [
16,
27
]
} |
later , the findings about the proteases are opposite and the protease content becomes greater in the pleural effusion . | NA | {
"id": "C0030940",
"name": "proteases",
"pos": [
31,
40
]
} | {
"id": "C0030946",
"name": "protease",
"pos": [
62,
70
]
} |
effects of the following amino acids were examined on the electrical activity of the two giant neurones ( pon and tan ) identified in the subesophageal ganglia of achatina fulica ferussac : l-asp , l-thr , l-ser , l-glu , l-pro , gly , l-alpha-ala , beta-ala , l-cysteine , l-cystine , l-val , l-met , l-ileu , l-leu , l... | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
25,
36
]
} | {
"id": "C0017890",
"name": "gly",
"pos": [
230,
233
]
} |
the content of three catecholamines ( dopamine , l-norepinephrine and l-epinephrine ) in the subesophageal ganglia and the hemolymph of achatina fulica ferussac was measured by a gas chromatograph with electron capture detector . | NA | {
"id": "C0028351",
"name": "l-norepinephrine",
"pos": [
49,
65
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
72,
83
]
} |
[ short term effects of docosenoic acid-containing oils on rat cardiac lipids : colza oil and partially hydrogenated herring oil ] . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
71,
77
]
} | {
"id": "C0028908",
"name": "oil",
"pos": [
125,
128
]
} |
glycosylation of 1,2:5,6-di-o-idopropylidene-alpha-d-galactofuranose with 2,3-di-o-acetyl-4-o- ( 2,3,4,6-tetra-o-acetyl-beta-d-mannopyranosyl ) -alpha-l-rhamn opyranosyl bromide , followed by removal of the protecting groups , gave o-beta-d-mannopyranosyl- ( 1 leads to 4 ) -o-alpha-l-rhamnopyranosyl- ( 1 leads to 3 ) -... | NA | {
"id": "C0069180",
"name": "o-specific",
"pos": [
383,
393
]
} | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
422,
440
]
} |
ring-opening of this 2',3'-epoxide with iodide anion afforded mainly 7- ( 4,6-o-benzylidene-2-deozy-2-iodo-beta-d-altropyranosyl ) theophylline , which was characterised as the 6'-acetate . | NA | {
"id": "C0021966",
"name": "iodide",
"pos": [
40,
46
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
47,
52
]
} |
the roles of increased metabolism and reduced penetration as possible mechanisms of resistance to carbaryl were investigated in a strain of a. albimanus from el salvador in which carbamate and organophosphorus resistance had been induced by laboratory selection with propoxur . | NA | {
"id": "C0036860",
"name": "carbaryl",
"pos": [
98,
106
]
} | {
"id": "C0006948",
"name": "carbamate",
"pos": [
179,
188
]
} |
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