text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
the mode of inheritance of resistance to parathion , fenitrothion , fenthion , chlorpyr fosmethyl , and parathion-methyl was studied in a strain of c. tarsalis . | NA | {
"id": "C0030514",
"name": "parathion",
"pos": [
41,
50
]
} | {
"id": "C0025709",
"name": "parathion-methyl",
"pos": [
104,
120
]
} |
in reaction mixture containing 0,1 m nacl and acetylcholine used as substrate , the kinetics of the inhibition of bovine erythrocyte acetylcholinesterase ( ec 3.1.1.7 ) by thioridazine hydrochloride and thiazinamium methylsulfate imply the simultaneous binding of two thioridazine or thiazinamium molecules at the free e... | NA | {
"id": "C0700499",
"name": "thioridazine hydrochloride",
"pos": [
172,
198
]
} | {
"id": "C0039943",
"name": "thioridazine",
"pos": [
337,
349
]
} |
when the antigen-coated beads were incubated with human igg antibody against hepatitis b surface antigen , immune complexes were formed on the solid phase surface . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
60,
68
]
} | {
"id": "C0003313",
"name": "immune complexes",
"pos": [
107,
123
]
} |
incubation of spleen cells from adult thymectomized mice on these cultures rendered rfc sensitive to inhibition by anti-theta serum , whereas no effect was obtained with fibroblasts or spleen cell cultures . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
21,
26
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
170,
181
]
} |
there was no depression of general cell-mediated immunity , in contrast to what occurs in systemic lupus erythematosus and related autoimmune diseases . | NA | {
"id": "C0024141",
"name": "systemic lupus erythematosus",
"pos": [
90,
118
]
} | {
"id": "C0004364",
"name": "autoimmune diseases",
"pos": [
131,
150
]
} |
the findings suggest that an antibody- or immune complex-mediated lymphocyte cytotoxicity may be involved in the pathogenesis of chronic liver diseases . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
29,
37
]
} | {
"id": "C0003313",
"name": "immune complex",
"pos": [
42,
56
]
} |
the effect of antisera to human alpha2-macroglobulin ( alpha2m ) on the ability of human peripheral blood lymphoid cells to lyse antibody coated target cells ( exert a k-cell effect ) and form t ( e ) and b ( eac ) rosettes has been investigated . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
14,
22
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
129,
137
]
} |
phytohaemagglutinin ( pha ) and concanavalin a ( con a ) stimulation were used as tests of thymus-dependent lymphocyte ( t cell ) function and bacterial endotoxin lipopolysaccharide ( lps ) was used as a probe of bursal equivalent lymphocyte ( b cell ) function . | NA | {
"id": "C0014264",
"name": "bacterial endotoxin",
"pos": [
143,
162
]
} | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
163,
181
]
} |
mice receiving high doses of mitomycin c-treated allogeneic spleen donor cells produced more host anti-donor plaque-forming cells than mice receiving high doses of untreated allogeneic spleen donor cells , showing that immunocompetent donor cells capable of recognizing host h-2 antigens can suppress host anti-donor h-2... | NA | {
"id": "C3485979",
"name": "allogeneic",
"pos": [
49,
59
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
241,
246
]
} |
patients with renal involvement showed a good correlation between high levels of dna binding , low serum c ' 3 and disease activity and typically , their dna-ep was negative . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
1,
2
]
} | {
"id": "C0012854",
"name": "dna-ep",
"pos": [
154,
160
]
} |
by contrast , patients without renal involvement in whom vasculitis was prominent , showed a poor correlation of dna binding capacity to changes in the state of their disease although the dna-ep test was persistently positive . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
8,
9
]
} | {
"id": "C0012854",
"name": "dna-ep",
"pos": [
188,
194
]
} |
specific antigens have been found in animal tumors and have been divided into two classes : the viral induced tumors , which share common antigens when caused by the same viral agent , and carcinogen-induced tumors , which appear to have unique antigenic determinants for each tumor . | NA | {
"id": "C0003320",
"name": "antigens",
"pos": [
9,
17
]
} | {
"id": "C0003316",
"name": "antigenic determinants",
"pos": [
245,
267
]
} |
the action of prostaglandins of the e and a groups on isolated aortic smooth muscle strips of rats with spontaneous hypertension ( okamoto-aoki ) ( shr ) was investigated in order to follow up whether , and to what extent , an alteration of vascular reactivity exists in this model of hypertension , as well as to test t... | NA | {
"id": "C0033559",
"name": "prostaglandins",
"pos": [
14,
28
]
} | {
"id": "C0033554",
"name": "prostaglandins",
"pos": [
347,
361
]
} |
these findings support the idea that satellite dna , which is concentrated in the c-band region , changes more quickly than bulk dna . | NA | {
"id": "C0012934",
"name": "satellite dna",
"pos": [
37,
50
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
129,
132
]
} |
intoxications due to cosmetics are of various types , but certain substances may be particularly harmful , especially when the constituants include acetone , boric acid and borates , ethyl alcohol , bromates , formol , methyl alcohol , propylene glycol , thallium , thioglycolate.. | NA | {
"id": "C0001962",
"name": "ethyl alcohol",
"pos": [
183,
196
]
} | {
"id": "C0001963",
"name": "methyl alcohol",
"pos": [
219,
233
]
} |
human red cell and plasma lipids are determined in alcoholic patients with various forms of liver diseases including steatosis , cirrhosis and hepatitis . | NA | {
"id": "C0023895",
"name": "of liver diseases",
"pos": [
89,
106
]
} | {
"id": "C0023890",
"name": "cirrhosis",
"pos": [
129,
138
]
} |
human red cell and plasma lipids are determined in alcoholic patients with various forms of liver diseases including steatosis , cirrhosis and hepatitis . | NA | {
"id": "C0023895",
"name": "of liver diseases",
"pos": [
89,
106
]
} | {
"id": "C0019158",
"name": "hepatitis",
"pos": [
143,
152
]
} |
it was found that exogenous ribonucleate increases the incorporation of the labeled precursors in the total rna , rrna and trna , this increase being more pronounced in trna than in rrna . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
108,
111
]
} | {
"id": "C0035701",
"name": "rrna",
"pos": [
182,
186
]
} |
skin porphyrin assays and photobiological studies in normal and porphyric rats suggest that in the latter , skin photosensitivity to 400 nm radiation is associated with raised uroporphyrin and 7-carboxylic porphyrin in the skin . | NA | {
"id": "C0042093",
"name": "uroporphyrin",
"pos": [
176,
188
]
} | {
"id": "C0032712",
"name": "porphyrin",
"pos": [
206,
215
]
} |
the authors have observed seven cases of this syndrome , and together with a review of the literature , they discuss the various facets which constitute this disease . | NA | {
"id": "C0039082",
"name": "syndrome",
"pos": [
46,
54
]
} | {
"id": "C0012634",
"name": "disease",
"pos": [
158,
165
]
} |
diseases such as ulcerative colitis , colonic polyposis and adenomatous polyps are pre-disposing conditions whereas familial polyposis is pre-cancerous . | NA | {
"id": "C0206677",
"name": "adenomatous polyps",
"pos": [
60,
78
]
} | {
"id": "C0032580",
"name": "familial polyposis",
"pos": [
116,
134
]
} |
the effect of vitamin b6 groups , pyridoxine , pyridoxamine , pyridoxal ( pyridoxal phosphate and pyridoxal phosphate ca ) on hepatic cholesterol and fatty acid biosynthesis in mice were studied . | NA | {
"id": "C0087162",
"name": "vitamin b6",
"pos": [
14,
24
]
} | {
"id": "C0034268",
"name": "pyridoxamine",
"pos": [
47,
59
]
} |
the effect of vitamin b6 groups , pyridoxine , pyridoxamine , pyridoxal ( pyridoxal phosphate and pyridoxal phosphate ca ) on hepatic cholesterol and fatty acid biosynthesis in mice were studied . | NA | {
"id": "C0087162",
"name": "vitamin b6",
"pos": [
14,
24
]
} | {
"id": "C0034263",
"name": "pyridoxal",
"pos": [
98,
107
]
} |
the effect of vitamin b6 groups , pyridoxine , pyridoxamine , pyridoxal ( pyridoxal phosphate and pyridoxal phosphate ca ) on hepatic cholesterol and fatty acid biosynthesis in mice were studied . | NA | {
"id": "C0034272",
"name": "pyridoxine",
"pos": [
34,
44
]
} | {
"id": "C0034266",
"name": "pyridoxal phosphate",
"pos": [
98,
117
]
} |
the dietary cholesterol supplement given pyridoxine fed mice did not produce any changes in liver cholesterol and fatty acid synthesis , and liver cholesterol level , while the increase of liver fatty acid and blood cholesterol biosynthesis were seen . | NA | {
"id": "C0008395",
"name": "dietary cholesterol",
"pos": [
4,
23
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
216,
227
]
} |
pancreatic beta cells secrete the proinsulin connecting peptide ( c-peptide ) and insulin on an equimolar basis . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
34,
44
]
} | {
"id": "C0006558",
"name": "connecting peptide",
"pos": [
45,
63
]
} |
pancreatic beta cells secrete the proinsulin connecting peptide ( c-peptide ) and insulin on an equimolar basis . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
34,
44
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
82,
89
]
} |
comparative evaluation of the tsh effect on the synthesis of different thyroidal proteins shows that it has a much more specific and significant action on thyroglobulin than on other proteins . | NA | {
"id": "C0034861",
"name": "synthesis",
"pos": [
48,
57
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
183,
191
]
} |
the differential effect of tsh on the synthesis of thyroglobulin and proteins other than thyroglobulin suggests that different mechanisms may exist by which tsh regulates the synthesis of these two types of proteins . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
69,
77
]
} | {
"id": "C0034861",
"name": "synthesis",
"pos": [
175,
184
]
} |
for the oxidation of ch3oh and 2h3coh , the ratio of vh/v2h3 = 2.44 , while the ratio for methanol/ethanol is only 1.3 . | NA | {
"id": "C0001963",
"name": "methanol",
"pos": [
90,
98
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
99,
106
]
} |
1 ) chondroitin sulfate and dermatan sulfate of bovine arterial tissue exist as copolymers with a varying degree of hybridization between chondroitin and dermatan sulfates . | NA | {
"id": "C0008466",
"name": "chondroitin sulfate",
"pos": [
4,
23
]
} | {
"id": "C0008454",
"name": "chondroitin",
"pos": [
138,
149
]
} |
1 ) chondroitin sulfate and dermatan sulfate of bovine arterial tissue exist as copolymers with a varying degree of hybridization between chondroitin and dermatan sulfates . | NA | {
"id": "C0008454",
"name": "chondroitin",
"pos": [
4,
15
]
} | {
"id": "C0011602",
"name": "dermatan sulfates",
"pos": [
154,
171
]
} |
the sedimentation of albumin under the action of the electric and gravitational fields was determined as a function of time in discontinuous experiments in a rectangular cell , using serum with the albumin fraction stained blue . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
21,
28
]
} | {
"id": "C0036773",
"name": "serum",
"pos": [
183,
188
]
} |
in continuous single-stage separation of gamma-globulin from other serum proteins , only about half the gamma-globulins can be obtained from the solution because it remains homogeneously distributed throughout the solution and is only free from albumin and other proteins in the upper half of the cell . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
245,
252
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
263,
271
]
} |
the amino acid composition of [ alpha1 ( iii ) ] 3 purified by cm-cellulose chromatography and agarose-gel chromatography includes two cysteine residues per chain , and the hydroxyproline/proline ratio is greater than 1.0 . | NA | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
173,
187
]
} | {
"id": "C0033382",
"name": "proline",
"pos": [
188,
195
]
} |
in two radioimmunoassay systems with iodinated human growth hormone as tracer and anti-human growth hormone or anti-porcine growth hormone as binding site , the standard curves for human and for porcine growth hormone were parallel . | NA | {
"id": "C0169964",
"name": "human growth hormone",
"pos": [
47,
67
]
} | {
"id": "C0037663",
"name": "growth hormone",
"pos": [
203,
217
]
} |
it was concluded that the human and the porcine hormones behave in an identical way and that the values obtained in radioimmunoassay for human growth hormone represent the amount of immunologically active molecules in the porcine growth hormone preparation . | NA | {
"id": "C0169964",
"name": "human growth hormone",
"pos": [
137,
157
]
} | {
"id": "C0037663",
"name": "growth hormone preparation",
"pos": [
230,
256
]
} |
as parallel standard curves were obtained with porcine serum , the concentration of growth hormone is porcine serum may be determined by radioimmunoassay for human growth hormone . | NA | {
"id": "C0037663",
"name": "growth hormone",
"pos": [
84,
98
]
} | {
"id": "C0169964",
"name": "human",
"pos": [
158,
163
]
} |
age ( 3.3 to 12.1 years ) did not significantly ( p less than .05 ) affect activities of the urea cycle enzymes ( per mg protein , per g liver or per w-75 kg/hr ) or plasma urea-nitrogen levels in the adult hereford female at the level of dietary protein fed in this study . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
121,
128
]
} | {
"id": "C0012177",
"name": "dietary protein",
"pos": [
239,
254
]
} |
this site appears to be the same involved in the binding of both substrates and inhibitors , with higher affinity for purine nucleotides than for pyrimidine compounds , in the order guanosine greater than adenosine greater than inosine greater than uridine greater than cytidine nucleotides . | NA | {
"id": "C0034137",
"name": "purine nucleotides",
"pos": [
118,
136
]
} | {
"id": "C0028630",
"name": "nucleotides",
"pos": [
279,
290
]
} |
dynamics of liver glycogen : the topochemistry of glycogen synthesis , glycogen content and glycogenolysis under the experimental conditions of glycogen accumulation and depletion . | NA | {
"id": "C0023902",
"name": "liver glycogen",
"pos": [
12,
26
]
} | {
"id": "C0017911",
"name": "glycogen",
"pos": [
144,
152
]
} |
the procedure uses mild periodate oxidation , followed by condensation with dansylhydrazine and reduction of the hydrazones to hydrazines . | NA | {
"id": "C0020235",
"name": "hydrazones",
"pos": [
113,
123
]
} | {
"id": "C0020233",
"name": "hydrazines",
"pos": [
127,
137
]
} |
a sudden increase in fetal plasma corticoids does not seem to be the stimulus for appearance of surfactant in the lamb , although these hormones may induce the rapid accumulation of surfactant prior to delivery . | NA | {
"id": "C0001617",
"name": "corticoids",
"pos": [
34,
44
]
} | {
"id": "C0019932",
"name": "hormones",
"pos": [
136,
144
]
} |
purified postheparin plasma lipoprotein lipase ( lpl ) of normolipidemic and primary hyperlipoproteinemic subjects was characterized by lipoprotein c polypeptide activation and specificity for triglycerides in chylomicrons and vldl . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
28,
39
]
} | {
"id": "C0008731",
"name": "chylomicrons",
"pos": [
210,
222
]
} |
disproportional changes were also seen during the recovery phase , when the hematocrit and hemoglobin concentration indicated a more rapid return of the plasma volume to preexercise levels than did either the plasma protein concentration or albumin activity . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
216,
223
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
241,
248
]
} |
resonance raman spectra were measured for various c-type cytochromes ( mammalian cytochrome c , bacterial cytochrome c3 , algal photosynthetic cytochrome f , and alkylated cytochrome c ) and a b-type cytochrome ( cytochrome b5 ) in their reduced and oxidized states . | NA | {
"id": "C1256752",
"name": "c-type cytochromes",
"pos": [
50,
68
]
} | {
"id": "C0010749",
"name": "cytochrome c",
"pos": [
172,
184
]
} |
resonance raman spectra were measured for various c-type cytochromes ( mammalian cytochrome c , bacterial cytochrome c3 , algal photosynthetic cytochrome f , and alkylated cytochrome c ) and a b-type cytochrome ( cytochrome b5 ) in their reduced and oxidized states . | NA | {
"id": "C1256752",
"name": "c-type cytochromes",
"pos": [
50,
68
]
} | {
"id": "C0010798",
"name": "cytochrome",
"pos": [
213,
223
]
} |
the gamma-globulin fraction of antiserum contained antibodies which combined with the purified atpase and the sr vesicles . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
31,
40
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
51,
61
]
} |
another copper-containing oxidase , squash ascorbate oxidase [ ec 1.10.3.3 ] , was not inhibited by the same compound at a concentration of 150 mm . | NA | {
"id": "C0003967",
"name": "ascorbate oxidase",
"pos": [
43,
60
]
} | {
"id": "C0030016",
"name": "ec 1",
"pos": [
63,
67
]
} |
enzyme levels of adenylylsulfate reductase , inorganic pyrophosphatase , sulfite reductase , hydrogenase , and adenosine triphosphatase in cells grown on sulfate , sulfite , and thiosulfate . | NA | {
"id": "C0038720",
"name": "sulfate",
"pos": [
25,
32
]
} | {
"id": "C0039950",
"name": "thiosulfate",
"pos": [
178,
189
]
} |
sulfate-reducing bacteria , desulfovibrio vulgaris , strain miyazaki , were grown on either sulfate , sulfite , or thiosulfate as the terminal electron acceptor . | NA | {
"id": "C0038720",
"name": "sulfate",
"pos": [
0,
7
]
} | {
"id": "C0039950",
"name": "thiosulfate",
"pos": [
115,
126
]
} |
enzyme levels of adenylylsulfate ( aps ) reductase [ ec 1.8.99.2 ] , reductant-activated inorganic pyrophosphatase [ ec 3.6.1.1 ] , sulfite reductase [ ec 1.8.99.1 ] ( desulfoviridin ) , hydrogenase [ ec 1.12.2.1 ] , and mg2+-activated atpase [ ec 3.6.1.3 ] were compared in crude extracts of these cells at various stag... | NA | {
"id": "C0020284",
"name": "hydrogenase",
"pos": [
187,
198
]
} | {
"id": "C0030016",
"name": "ec",
"pos": [
245,
247
]
} |
2 ) cells grown on sulfite had lower specific activity of reductant-activated inorganic pyrophosphatase than cells grown on sulfate or thiosulfate . | NA | {
"id": "C0038720",
"name": "sulfate",
"pos": [
124,
131
]
} | {
"id": "C0039950",
"name": "thiosulfate",
"pos": [
135,
146
]
} |
it is suggested that the heme iron of the metmyoglobin peroxide compound is in an oxidation state other than the ferric state and that the porphyrin structure of metmyoglobin may be modified by the reaction with hydrogen peroxide . | NA | {
"id": "C0031180",
"name": "peroxide",
"pos": [
55,
63
]
} | {
"id": "C0020281",
"name": "hydrogen peroxide",
"pos": [
212,
229
]
} |
the cold water-insoluble d-fructans from strep . mutans strain bht and jc-1 have inulin-type structures consisting beta- ( 2 leads to 1 ) -d-fructofuranosidic linkages , with average repeating units of 8 and 27 sugar residues , respectively , whereas the water-soluble fructan from strep . salivarius strain hht has a le... | NA | {
"id": "C0016743",
"name": "fructans",
"pos": [
27,
35
]
} | {
"id": "C0021936",
"name": "inulin",
"pos": [
81,
87
]
} |
the complex of dna with polymerase a was stable and the polymerase was not removed from the initial complex even when a large amount of dna was added . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
15,
18
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
144,
145
]
} |
cells of a newly established rat fibroblast line ( sen ) in culture synthesize mucopolysaccharides , which have been identified as hyaluronic acid , chondroitin-4-sulfate and heparan sulfate . | NA | {
"id": "C0017973",
"name": "mucopolysaccharides",
"pos": [
79,
98
]
} | {
"id": "C0019143",
"name": "heparan sulfate",
"pos": [
175,
190
]
} |
the proliferation of these components results in the combined malformations , whose occurrence , we believe , is more supporting evidence for the idea that pigmented nevi may have other components besides nevus cells . | NA | {
"id": "C0027962",
"name": "pigmented nevi",
"pos": [
156,
170
]
} | {
"id": "C0027960",
"name": "nevus",
"pos": [
205,
210
]
} |
the commonly accepted concept that salivary calculi emanate from an inorganic nucleus , which then successively grows by the apposition of alternating shells of organic and inorganic substances , could not be established by this study , as the microradiographs show that the distribution of mineral elements varied exten... | NA | {
"id": "C0752168",
"name": "salivary calculi",
"pos": [
35,
51
]
} | {
"id": "C0006736",
"name": "calculus",
"pos": [
336,
344
]
} |
using radiological and histological methods the growth of the long bones in the pyridoxine-deficient rats from 2 wk to 6 mth of age was compared with that in paired-fed and in paired-weight-gain control rats of the same age and sex given the same diet supplemented by daily injections of pyridoxine hydrochloride . | NA | {
"id": "C0034272",
"name": "deficient",
"pos": [
91,
100
]
} | {
"id": "C0700496",
"name": "pyridoxine hydrochloride",
"pos": [
288,
312
]
} |
prior to the onset of cirrhosis the liver showed a characteristic lesion consisting of hepatomegaly , periportal fatty change , portal cellularity due to proliferation of ovoid and cuboidal duct cells , gross enlargement of the hepatocyte cytoplasm nuclei and nucleoli in spite of brisk mitotic activity , and focal cent... | NA | {
"id": "C0019209",
"name": "hepatomegaly",
"pos": [
87,
99
]
} | {
"id": "C0020564",
"name": "enlargement",
"pos": [
209,
220
]
} |
phentermine ( ib ) , n-hydroxymephentermine ( ic ) and n-hydroxyphentermine ( id ) were identified as metabolic products after in vitro incubation of mephentermine ( ia ) with rabbit liver microsomal fractions . | NA | {
"id": "C0031447",
"name": "phentermine",
"pos": [
0,
11
]
} | {
"id": "C0025380",
"name": "mephentermine",
"pos": [
150,
163
]
} |
this study examines the effects of cue salience and palatability ( water temperature ) on the water drinking of obese and normal subjects . | NA | {
"id": "C0043047",
"name": "water",
"pos": [
67,
72
]
} | {
"id": "C0599638",
"name": "water drinking",
"pos": [
94,
108
]
} |
dopamine , noradrenaline and adrenaline inhibit the late response as well as ganglionic activity induced by other means . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
11,
24
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
29,
39
]
} |
two microelectrodes ( recording and current-injecting ) were inserted into the lumen of single proximal tubules and the peritubular perfusate was shifted reversibly for 30-60 sec from a physiologic ringer 's solution to a test solution in which chloride was replaced isosmotically by a foreign anion . | NA | {
"id": "C0008203",
"name": "chloride",
"pos": [
245,
253
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
294,
299
]
} |
transepithelial conductance decreased when the tissue was perfused with anions less permeable than chloride but the conductance sequence was different from the permeability sequence . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
72,
78
]
} | {
"id": "C0008203",
"name": "chloride",
"pos": [
99,
107
]
} |
aspiration and its sequelae ( aspiration pneumonia , lipid pneumonia ) appears to be a major problem in this population , upon which prevention programmes could concentrate . | NA | {
"id": "C0032290",
"name": "aspiration pneumonia",
"pos": [
30,
50
]
} | {
"id": "C0032298",
"name": "lipid pneumonia",
"pos": [
53,
68
]
} |
approximately one-half of the cells ( lymphocytes and fibroblasts ) showed a normal karyotype 46 , xx , the other half a dicentric translocation chromosome . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
30,
35
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
54,
65
]
} |
the following amino acids have been identified and quantitated : glycine , d , l-erythro- and d , l-threo-beta - hydroxyaspartic acids , d , l glutamic acid , and d , l-threonine and allo-threonine . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
14,
25
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
65,
72
]
} |
[ experimental respiratory infection of klebsiella pneumoniae in mice . i. conditions necessary for development of the infection ] . | NA | {
"id": "C0035243",
"name": "respiratory infection",
"pos": [
15,
36
]
} | {
"id": "C0009450",
"name": "infection",
"pos": [
119,
128
]
} |
only the peak of the blood sugar curve was shifted from one to two and a half hours after glucose administration ; | NA | {
"id": "C0005802",
"name": "blood sugar",
"pos": [
21,
32
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
90,
97
]
} |
it is suggested that corticosteroid hormones may play a role in the changes in leucocyte migration observed during anaesthesia and surgical stress . | NA | {
"id": "C0001617",
"name": "corticosteroid",
"pos": [
21,
35
]
} | {
"id": "C0019932",
"name": "hormones",
"pos": [
36,
44
]
} |
protective effect of tryptophan and 5-hydroxytryptophan on experimental phenylketonuria induced with phenylalanine+ p-cholorophenylalanine in rats . | NA | {
"id": "C0041249",
"name": "tryptophan",
"pos": [
21,
31
]
} | {
"id": "C0000578",
"name": "5-hydroxytryptophan",
"pos": [
36,
55
]
} |
an experimental phenylketonuria-like syndrome was produced in rats by oral administration of 1-phenylalanine ( phe , 500 mg/kg ) and dl-p-chloro-phenylalanine ( pcpa , 100-125 mg/kg ) daily from the 2nd-3rd day of life to the age of 42 days . | NA | {
"id": "C0031453",
"name": "phe",
"pos": [
16,
19
]
} | {
"id": "C0030135",
"name": "pcpa",
"pos": [
161,
165
]
} |
the effects of added dl-5-hydroxytryptohan ( 5htp , 5 mg/kg ) or 1-tryptophan ( trp , 100-125 mg/kg ) were also studied . | NA | {
"id": "C0000578",
"name": "5htp",
"pos": [
45,
49
]
} | {
"id": "C0041249",
"name": "tryptophan",
"pos": [
67,
77
]
} |
the groups receiving phe+pcpa gained less weight than normal and less than the phe controls . | NA | {
"id": "C0030135",
"name": "pcpa",
"pos": [
25,
29
]
} | {
"id": "C0031453",
"name": "phe",
"pos": [
79,
82
]
} |
when tested during the last week of treatment the phe+pcpa rats made more errors in the swim maze without changes in swimming times , and they showed significantly poorer learning of conditioned shock avoidance . | NA | {
"id": "C0031453",
"name": "phe",
"pos": [
50,
53
]
} | {
"id": "C0030135",
"name": "pcpa",
"pos": [
54,
58
]
} |
the accumulation of filaments in the fibroblast causes a degenerative final stage of the cells . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
37,
47
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
89,
94
]
} |
the diagnosis of malignant lymphomas ( hodgkin 's and non-hodgkin 's type ) predominanted ( 55 cases ) in the own case material of 94 patients . | NA | {
"id": "C0024299",
"name": "malignant lymphomas",
"pos": [
17,
36
]
} | {
"id": "C0024305",
"name": "non-hodgkin 's",
"pos": [
54,
68
]
} |
the dependence of postoperative haemorrhages on meteorological influences would perhaps give a reason for the hitherto medically unexplainable 40 per cent bleedings . | NA | {
"id": "C0032788",
"name": "postoperative haemorrhages",
"pos": [
18,
44
]
} | {
"id": "C0019080",
"name": "bleedings",
"pos": [
155,
164
]
} |
there are several types to be classified according to clinical and radiological findings and histologic diagnosis ewing 's sarcoma and osteogenic sarcoma ; | NA | {
"id": "C0553580",
"name": "ewing 's sarcoma",
"pos": [
114,
130
]
} | {
"id": "C0029463",
"name": "osteogenic",
"pos": [
135,
145
]
} |
sensitivity of subcutaneous small arteries and veins to norepinephrine , and epinephrine , and isoproterenol in the unanesthetized bat . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
56,
70
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
77,
88
]
} |
regulation of two microbiological processes -- 1-dehydrogenation and 20 beta-reduction of ketosteroids -- was studied using several exogeneous quinones which ( a ) stimulated 1-dehydrogenation and ( b ) inhibited the accompanying reaction , the reduction of 20-ketogroup of the steroid molecule . | NA | {
"id": "C0022640",
"name": "ketosteroids",
"pos": [
90,
102
]
} | {
"id": "C0038317",
"name": "steroid",
"pos": [
278,
285
]
} |
the effect of various nitrogen sources ( l-glutamic acid , l-glutamine , l-aspartic acid , l-asparagine , and ammonium sulphate ) on the synthetase and transferase activity of glutamine synthetase was studied in candida tropicalis . | NA | {
"id": "C0061472",
"name": "l-glutamic acid",
"pos": [
41,
56
]
} | {
"id": "C0017797",
"name": "l-glutamine",
"pos": [
59,
70
]
} |
two strains of the yeast candida lipolytica with a specific response to n-alkanes could grow on a medium with paraffins only in the case of contact of the cells with the particles of hydrocarbons . | NA | {
"id": "C0030415",
"name": "paraffins",
"pos": [
110,
119
]
} | {
"id": "C0020242",
"name": "hydrocarbons",
"pos": [
183,
195
]
} |
the bacterium is a facultative methylotroph and grows not only on media with various organic compounds but also in the presence of methylated amines as a sole source of carbon , nitrogen , and energy . | NA | {
"id": "C0029224",
"name": "organic compounds",
"pos": [
85,
102
]
} | {
"id": "C0002508",
"name": "amines",
"pos": [
142,
148
]
} |
thus , although there was a direct relationship between birth weight and placental weight , the distribution of weight of children with either large or small placentas was not significantly different from the expected normal distribution at one year of age . | NA | {
"id": "C0005612",
"name": "birth weight",
"pos": [
56,
68
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
112,
118
]
} |
penicillin-insensitive pneumococci , of 10 serotypes , which had been isolated in australia and new guinea from healthy carriers and patients with pneumococcal infections , were shown to be relatively resistant to penicillin g , penicillin v , methicillin , cloxacillin , cephaloridine and cephalothin , compared with pn... | NA | {
"id": "C0030842",
"name": "penicillin",
"pos": [
0,
10
]
} | {
"id": "C0030840",
"name": "penicillin v",
"pos": [
229,
241
]
} |
penicillin-insensitive pneumococci , of 10 serotypes , which had been isolated in australia and new guinea from healthy carriers and patients with pneumococcal infections , were shown to be relatively resistant to penicillin g , penicillin v , methicillin , cloxacillin , cephaloridine and cephalothin , compared with pn... | NA | {
"id": "C0030842",
"name": "penicillin",
"pos": [
0,
10
]
} | {
"id": "C0025643",
"name": "methicillin",
"pos": [
244,
255
]
} |
it differs from that of the wild-type protein by the lack of five amino acids and the appearance of a c-terminal glycine residue instead of a lysine residue . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
66,
77
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
113,
120
]
} |
mature 26-s + 5.8-s rrna was found to have a molecular weight of 1.24 x 10 ( 6 ) while their immediate precursor , 29-s rna , had a molecular weight of 1.52 x 10 ( 6 ) . | NA | {
"id": "C0035701",
"name": "rrna",
"pos": [
20,
24
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
120,
123
]
} |
2 ) the multiplication of the one-stage isotope effect by means of the repeated circulation of a light isotope fraction ( c2-fragments ) in lipid-carbohydrate metabolism and by the simultaneous removal of a heavy isotope carbon dioxide in the krebs cycle . | NA | {
"id": "C0022262",
"name": "isotope",
"pos": [
40,
47
]
} | {
"id": "C0007017",
"name": "isotope carbon",
"pos": [
213,
227
]
} |
weakly fluorescent and nonfluorescent associates of chlorophyll and its analogues as well as of bacteriochlorophyll and neoxanthine have been used as donors and acceptors . | NA | {
"id": "C0008260",
"name": "chlorophyll",
"pos": [
52,
63
]
} | {
"id": "C0004638",
"name": "bacteriochlorophyll",
"pos": [
96,
115
]
} |
[ a compact form of dna in solution . iii . influence of the ion composition of the solution on the compactization process of double-stranded dna in the presence of peg ] . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
2,
3
]
} | {
"id": "C0012854",
"name": "double-stranded dna",
"pos": [
126,
145
]
} |
to display its activity polyphosphatase requires the presence of bivalent cations of some metals , mg2+ ions being the best activator with co2+ , mn2+ and fe2+ ions-slightly less effective . | NA | {
"id": "C0007447",
"name": "cations",
"pos": [
74,
81
]
} | {
"id": "C0022023",
"name": "ions",
"pos": [
160,
164
]
} |
the nucleic acid of the p+f phage is double-stranded dna of at-type ( gc equals 34.5 mole % ) which contains 5-methylcytosine ( 0.18 mole % ) and n6-methyladenine ( 0.32 mole % ) . | NA | {
"id": "C0028606",
"name": "nucleic acid",
"pos": [
4,
16
]
} | {
"id": "C0012854",
"name": "double-stranded dna",
"pos": [
37,
56
]
} |
nucleotidyl- ( 5 ' leads to n ) -amino acids containing different heterocycle bases : adenine , guanine , hypoxanthine , cytosine , uracyl , and aromatic amino acids : phenylalanine , tyrosine and tryptophan , have been investigated by proton magnetic resonance and circular dichroism . | NA | {
"id": "C0301713",
"name": "aromatic amino acids",
"pos": [
145,
165
]
} | {
"id": "C0031453",
"name": "phenylalanine",
"pos": [
168,
181
]
} |
nucleotidyl- ( 5 ' leads to n ) -amino acids containing different heterocycle bases : adenine , guanine , hypoxanthine , cytosine , uracyl , and aromatic amino acids : phenylalanine , tyrosine and tryptophan , have been investigated by proton magnetic resonance and circular dichroism . | NA | {
"id": "C0301713",
"name": "aromatic amino acids",
"pos": [
145,
165
]
} | {
"id": "C0041485",
"name": "tyrosine",
"pos": [
184,
192
]
} |
nucleotidyl- ( 5 ' leads to n ) -amino acids containing different heterocycle bases : adenine , guanine , hypoxanthine , cytosine , uracyl , and aromatic amino acids : phenylalanine , tyrosine and tryptophan , have been investigated by proton magnetic resonance and circular dichroism . | NA | {
"id": "C0301713",
"name": "aromatic amino acids",
"pos": [
145,
165
]
} | {
"id": "C0041249",
"name": "tryptophan",
"pos": [
197,
207
]
} |
it was found that the distribution of pyrimidine isopliths between dna cistrons coding for different proteins is other than random and has a `` '' dna-like '' '' character . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
67,
70
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
166,
167
]
} |
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