text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
porphyria variegata , one of the rarer forms of hepatic porphyria , is brought to the attention through presentation of one case . | NA | {
"id": "C0162532",
"name": "porphyria variegata",
"pos": [
0,
19
]
} | {
"id": "C0162533",
"name": "hepatic porphyria",
"pos": [
48,
65
]
} |
mutagenic activity of cyclophosphamide , trofosfamide , and ifosfamide in drosophila melanogaster . specific induction of recessive lethals in the absence of detectable chromosome breakage . | NA | {
"id": "C0010583",
"name": "cyclophosphamide",
"pos": [
22,
38
]
} | {
"id": "C0020823",
"name": "ifosfamide",
"pos": [
60,
70
]
} |
the mutagenicity of cyclophosphamide ( endoxanr ) , trofosfamide ( ixotenr ) , and ifosfamide was tested on male germ cells , mainly mature sperm , of drosophila melanogaster . | NA | {
"id": "C0010583",
"name": "cyclophosphamide",
"pos": [
20,
36
]
} | {
"id": "C0020823",
"name": "ifosfamide",
"pos": [
83,
93
]
} |
human diploid fibroblast-like cells derived from four patients with the genetic disease ataxia telangiectasia and from two non-mutant donors were examined for the repair of x-ray induced strand breaks in dna . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
14,
24
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
30,
35
]
} |
to study the distribution of nuclear rna in the cytoplasm , the 3h-uracil labeled nuclei were transplanted in the rhizoids of unlabeled plants , the dikaryons obtained were kept for different time in the light and in the darkness and the content of 3h-rna was determined in different stem regions . | NA | {
"id": "C0035700",
"name": "nuclear rna",
"pos": [
29,
40
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
252,
255
]
} |
the age patterns were established in the activity of cytoplasmic ( ck-1 , ck-2 and ck-3 ) and mitochondrial ( ck-4 ) isozymes . | NA | {
"id": "C0010287",
"name": "ck",
"pos": [
67,
69
]
} | {
"id": "C0914594",
"name": "mitochondrial",
"pos": [
94,
107
]
} |
the results show that these patients have a normal affinity of haemoglobin for oxygen : the 2-3 d.p.g . was 13.05 +/- 2.2 mum.g-1 hb ; | NA | {
"id": "C0019016",
"name": "a",
"pos": [
19,
20
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
130,
132
]
} |
it thus appears that hypovitaminosis d alone , of particular severity , was sufficient to result in the appearance of clinically evident osteomalacia . | NA | {
"id": "C0035579",
"name": "hypovitaminosis d",
"pos": [
21,
38
]
} | {
"id": "C0029442",
"name": "osteomalacia",
"pos": [
137,
149
]
} |
the course was in general favourable though two deaths occurred in this series ( 4 p. cent ) , one with tuberculous pericarditis and the other with idiopathic pericarditis . | NA | {
"id": "C0031049",
"name": "tuberculous pericarditis",
"pos": [
104,
128
]
} | {
"id": "C0031046",
"name": "pericarditis",
"pos": [
159,
171
]
} |
the studied polyamides were found to be unfit for medical articles manufacture without removal of soluble components of the plastics . | NA | {
"id": "C0028736",
"name": "polyamides",
"pos": [
12,
22
]
} | {
"id": "C0032167",
"name": "plastics",
"pos": [
124,
132
]
} |
the initial pass through the chamber yields a fraction that is predominantly albumin and several alpha1-proteins . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
77,
84
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
104,
112
]
} |
after removal of albumin by affinity chromatography , a second pass through the chamber separates the individual alpha1-proteins . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
17,
24
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
120,
128
]
} |
excretion of the vaso-active amines tyramine , serotonin , noradrenaline , adrenaline and histamine and blood levels of serotonin , noradrenaline , adrenaline and histamine , were estimated in 10 patients before , during and after an attack of migraine . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
59,
72
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
148,
158
]
} |
there was no correlation between the proportion of noradrenaline to adrenaline produced by the tumour and the presence or absence of headache or the nature of the headache . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
51,
64
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
68,
78
]
} |
the effect of tryptophan and a tryptophan/5-hydroxytryptophan combination on indoles in the brains of rats fed a tryptophan deficient diet . | NA | {
"id": "C0000578",
"name": "hydroxytryptophan",
"pos": [
44,
61
]
} | {
"id": "C0041249",
"name": "tryptophan",
"pos": [
113,
123
]
} |
5-hydroxytryptophan and l-tryptophan administered to these deficient rats in a combination ( 5:95 ) produced a greater elevation of indolamines and tryptophan in the brain than either amino acid alone . | NA | {
"id": "C0000578",
"name": "5-hydroxytryptophan",
"pos": [
0,
19
]
} | {
"id": "C0041249",
"name": "tryptophan",
"pos": [
148,
158
]
} |
5-hydroxytryptophan reduced the induction of kynurenine synthesis in the liver produced by tryptophan , implying that it is capable of inhibiting the enzyme tryptophan pyrrolase in vivo . | NA | {
"id": "C0000578",
"name": "5-hydroxytryptophan",
"pos": [
0,
19
]
} | {
"id": "C0041249",
"name": "tryptophan",
"pos": [
157,
167
]
} |
[ the fate of heterologous antigen ( 131i-hsa ) in the organs of chickens exposed to total-body x-irradiation before a secondary antigenic stimulus ( author 's transl ) ] . | NA | {
"id": "C0003333",
"name": "heterologous antigen",
"pos": [
14,
34
]
} | {
"id": "C0003320",
"name": "antigenic",
"pos": [
129,
138
]
} |
similarly in patients bleeding from inflammatory bowel disease or in patients with post-operative hemorrhage , angiography provides information about the nature of the lesion and selective arterial infusions of vasopressin can control the bleeding . | NA | {
"id": "C0032788",
"name": "post-operative hemorrhage",
"pos": [
83,
108
]
} | {
"id": "C0019080",
"name": "bleeding",
"pos": [
239,
247
]
} |
relative uterine stimulating potencies of some natural prostaglandins and prostaglandin analogs tested after acute intravenous administration in mid-pregnant rhesus monkeys corresponded with the pge1 binding inhibition of the respective compound . | NA | {
"id": "C0033554",
"name": "prostaglandins",
"pos": [
55,
69
]
} | {
"id": "C0033568",
"name": "prostaglandin analogs",
"pos": [
74,
95
]
} |
according to cleland 's theoretical predictions , inosine phosphorolysis catalyzed by chicken and pigeon 's liver pnpase ( purine nucleoside : ortophosphate ribosyltransferase . | NA | {
"id": "C0021528",
"name": "inosine",
"pos": [
50,
57
]
} | {
"id": "C0034136",
"name": "purine nucleoside",
"pos": [
123,
140
]
} |
when creatine , in the concentration range known to be present in the cardiac tissue , is added to the growth medium of the cultured myocardial cells , the intracellular concentration of phosphorylcreatine increases up to 100 % . | NA | {
"id": "C0010286",
"name": "creatine",
"pos": [
5,
13
]
} | {
"id": "C0031634",
"name": "phosphorylcreatine",
"pos": [
187,
205
]
} |
this stimulation of energy production is due to the regeneration of mitochondrial adp brought about by the phosphosphorylation of creatine to phosphorylcreatine and possibly , also , to an enhanced rate of glycolysis . | NA | {
"id": "C0010286",
"name": "creatine",
"pos": [
130,
138
]
} | {
"id": "C0031634",
"name": "phosphorylcreatine",
"pos": [
142,
160
]
} |
creatine-phosphorylcreatine system operates as a undirectional shuttle for approximately p and as a control system regulating energy production according to demand . | NA | {
"id": "C0010286",
"name": "creatine",
"pos": [
0,
8
]
} | {
"id": "C0031634",
"name": "phosphorylcreatine",
"pos": [
9,
27
]
} |
the data suggest that there are 2 moles of myosin light chains per mole of myosin heavy chains in right ventricular myosin where the adenosine triphosphatase ( atpase ) activity is low and 1 mole of myosin light chains per mole of myosin heavy chains in left ventricula myosin where atpase activity is elevated ; | NA | {
"id": "C0027096",
"name": "myosin",
"pos": [
43,
49
]
} | {
"id": "C0027100",
"name": "myosin heavy chains",
"pos": [
231,
250
]
} |
for skeletal muscle myosin there were 1.5 moles of myosin light chains per mole of myosin heavy chains . | NA | {
"id": "C0027096",
"name": "myosin",
"pos": [
20,
26
]
} | {
"id": "C0027100",
"name": "myosin heavy chains",
"pos": [
83,
102
]
} |
it appears that the proportion of myosin light chain c1 to light chain c2 is directly related to the type of myosin heavy chain present since the immunologically identical heavy chains of cardiac tissue were immunologically nonidentical with those of skeletal muscle myosin . | NA | {
"id": "C0027100",
"name": "myosin heavy chain",
"pos": [
109,
127
]
} | {
"id": "C0027096",
"name": "myosin",
"pos": [
267,
273
]
} |
addition of monovalent cations to the divalent cation activating system lowered the activity of myosin , and the converse was true : divalent cations lowered the activity of myosin when activated by monovalent ones in a monovalent cation activating system . | NA | {
"id": "C0007449",
"name": "monovalent cations",
"pos": [
12,
30
]
} | {
"id": "C0007447",
"name": "cation",
"pos": [
231,
237
]
} |
addition of monovalent cations to the divalent cation activating system lowered the activity of myosin , and the converse was true : divalent cations lowered the activity of myosin when activated by monovalent ones in a monovalent cation activating system . | NA | {
"id": "C0007448",
"name": "divalent cations",
"pos": [
133,
149
]
} | {
"id": "C0007447",
"name": "cation",
"pos": [
231,
237
]
} |
the duration of antinociceptive action of alpha-l-acetylmethadol ( lam ) , determined in the rat tail pinch test , was 6 times that of morphine and 3 times that of methadone . | NA | {
"id": "C0025607",
"name": "acetylmethadol",
"pos": [
50,
64
]
} | {
"id": "C0025605",
"name": "methadone",
"pos": [
164,
173
]
} |
both heart endothelioid and muscle cells were used to study the effects of beta-lipoprotein with and without cholesterol or cholesterol esters on lysosomal or mitochondrial lability . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
109,
120
]
} | {
"id": "C0008387",
"name": "cholesterol",
"pos": [
124,
135
]
} |
the laboratory of enzymology of the institute of internal medicine has achieved screening tests for the estimation of alkaline phosphatase , of total lactatedehydrogenase and of its fraction i , whose results are in agreement with the reference methods of bessy-lowry-brock and of lac-dehystrate-goedecke in cases of acu... | NA | {
"id": "C0005940",
"name": "bone diseases",
"pos": [
364,
377
]
} | {
"id": "C0029401",
"name": "paget 's",
"pos": [
380,
388
]
} |
along with the established masking effect of sc on the antigenicity of j chains present in secretory iga , these results are compatible with the idea that the conformation of ig-associated j chains contributes to the sc-binding site of ig polymers . | NA | {
"id": "C0036538",
"name": "sc",
"pos": [
45,
47
]
} | {
"id": "C0020838",
"name": "secretory iga",
"pos": [
91,
104
]
} |
using rocket immunoelectrophoresis and indirect haemagglutination tests , antibodies to nicotinic acetylcholine receptor ( n-achr ) from torpedo marmorata were detected in sera from rabbits with experimental myasthenia but not in sera from patients with myasthenia gravis or in rabbit antisera to a partly purified skele... | NA | {
"id": "C0752087",
"name": "experimental myasthenia",
"pos": [
195,
218
]
} | {
"id": "C0026896",
"name": "myasthenia gravis",
"pos": [
254,
271
]
} |
antibodies to this antigen were demonstrated in sera from patients with myasthenia gravis but not in sera from rabbits with experimental myasthenia . | NA | {
"id": "C0026896",
"name": "myasthenia gravis",
"pos": [
72,
89
]
} | {
"id": "C0752087",
"name": "experimental myasthenia",
"pos": [
124,
147
]
} |
the 24-h urinary excretion of tetracyclines was slightly higher in patients receiving the combination of terpenes and tetracycline , but these differences in urinary excretion did not appear to have any influence on the antibacterial effect of tetracyclines . | NA | {
"id": "C0039644",
"name": "tetracycline",
"pos": [
30,
42
]
} | {
"id": "C0039651",
"name": "tetracyclines",
"pos": [
244,
257
]
} |
the commonest pathogens , haemophilus influenzae and pneumococci , are usually sensitive to ampicillin and amoxycillin , cotrimoxazole ( bactrim or eusaprim ) and tetracyclines . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
92,
102
]
} | {
"id": "C0002645",
"name": "amoxycillin",
"pos": [
107,
118
]
} |
the complement system may be activated by at least two different pathways : the clinical pathway involving c1 , c4 and c2 and the alternative pathway involving properdin , c3 , factor b and factor d . | NA | {
"id": "C0009498",
"name": "complement",
"pos": [
4,
14
]
} | {
"id": "C0033453",
"name": "factor b",
"pos": [
177,
185
]
} |
the dopamine theory of schizophrenia postulates a pathogenetic connection between the disease and changes in the activity of dopaminergic cells in the brain . | NA | {
"id": "C0013030",
"name": "dopamine",
"pos": [
4,
12
]
} | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
125,
137
]
} |
out of 8 cases of sjorgren 's syndrome observed by the authors between 1964 and 1974 , 5 presented wit clinically as well as theoretically remarkable combinations of sjogren 's syndrome with lymphoproliferative disorders i.e . non-classifiable lymphoproliferative disease ( case 1 ) , hodgkin 's disease ( case 2 ) , ret... | NA | {
"id": "C0039082",
"name": "syndrome",
"pos": [
30,
38
]
} | {
"id": "C0012634",
"name": "disorders",
"pos": [
211,
220
]
} |
it is concluded that the incidence of significant bacteriuria after a vcu is not inconsiderable , that this urinary tract infection is often asymptomatic , and that the prophylactic administration of a disinfectant is justified . | NA | {
"id": "C0004659",
"name": "bacteriuria",
"pos": [
50,
61
]
} | {
"id": "C0042029",
"name": "urinary tract infection",
"pos": [
108,
131
]
} |
the cases are presented of 4 hydantreated epileptic patients developing malignant lymphomas ( 1 hodgkin 's lymphoma ) . | NA | {
"id": "C0024299",
"name": "malignant lymphomas",
"pos": [
72,
91
]
} | {
"id": "C0019829",
"name": "hodgkin 's lymphoma",
"pos": [
96,
115
]
} |
among the various infectious and parasitic disease liable to produce granulopenia , the authors selected certain diseases which represented their personal experience . | NA | {
"id": "C0009450",
"name": "infectious",
"pos": [
18,
28
]
} | {
"id": "C0030499",
"name": "parasitic disease",
"pos": [
33,
50
]
} |
the occurrence of different hl-a antigens in association with the same disease in different ethnic groups requires that the use of a major histocompatibility system antigen as a disease susceptibility marker must be confirmed for each ethnic group under study . | NA | {
"id": "C0019721",
"name": "hl-a antigens",
"pos": [
28,
41
]
} | {
"id": "C0019628",
"name": "histocompatibility",
"pos": [
139,
157
]
} |
increase in plasma volume which occurs during pregnancy is suggested as the cause of the fall in serum enzyme activity in the second trimester whereas the rise in enzyme activity in the third trimester is attributed to the well-known increase in serum alkaline phosphatase of placental origin . | NA | {
"id": "C0032961",
"name": "pregnancy",
"pos": [
46,
55
]
} | {
"id": "C0032980",
"name": "second trimester",
"pos": [
126,
142
]
} |
increase in plasma volume which occurs during pregnancy is suggested as the cause of the fall in serum enzyme activity in the second trimester whereas the rise in enzyme activity in the third trimester is attributed to the well-known increase in serum alkaline phosphatase of placental origin . | NA | {
"id": "C0032961",
"name": "pregnancy",
"pos": [
46,
55
]
} | {
"id": "C0032981",
"name": "third trimester",
"pos": [
186,
201
]
} |
in the post infection urine samples , increases in total proteinuria , albuminuria and gamma-globulinuria were noted a few weeks after peak parasitaemia . | NA | {
"id": "C0033687",
"name": "proteinuria",
"pos": [
57,
68
]
} | {
"id": "C0001925",
"name": "albuminuria",
"pos": [
71,
82
]
} |
it means that the studied soluble neutral peptide-hydrolases of grey and white matter of the cat cerebral hemisphere may be referred to the group of exopeptidases . | NA | {
"id": "C0030940",
"name": "peptide-hydrolases",
"pos": [
42,
60
]
} | {
"id": "C0117059",
"name": "exopeptidases",
"pos": [
149,
162
]
} |
the conditions were developed for preparative isolation of thiamine triphosphate ( ttp ) from a mixture of phosphoric acid esters of thiamine ( pet ) ( 40-80 mg thiamine ) . | NA | {
"id": "C0039853",
"name": "thiamine triphosphate",
"pos": [
59,
80
]
} | {
"id": "C0039840",
"name": "thiamine",
"pos": [
161,
169
]
} |
in comparison with electrophoresis and paper chromatography , the preparative isolation of ttp and tdp by the ion-exchange chromagraphic method is less laborious and permits larger amounts of pet to be separated for a single run . | NA | {
"id": "C0039853",
"name": "ttp",
"pos": [
91,
94
]
} | {
"id": "C0039840",
"name": "pet",
"pos": [
192,
195
]
} |
in the direct and indirect immunofluorescent staining we detected the main antigenic determinants of the siga molecule , i. e. the heavy chains and the secretory component . | NA | {
"id": "C0020838",
"name": "siga",
"pos": [
105,
109
]
} | {
"id": "C0036538",
"name": "secretory component",
"pos": [
152,
171
]
} |
considering the relations of cells to each other and to vessels the prevailing origin of tumor cells from preexisting fibroblasts is suggested . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
29,
34
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
118,
129
]
} |
the state of the metabolism was estimated by monitoring the content of radioactive thiamin in tissues and blood and by following its excretion . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
17,
27
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
133,
142
]
} |
the so-called uncontrollable hemorrhage in obstetric patients correlated mainly with appearance in blood of complex heparin compounds , primarily fibrinogen-heparin , adrenaline-heparin , noradrenaline-heparin and , less frequently , plasminogen-heparin . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
167,
177
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
188,
201
]
} |
single administration of hydrocortisone into rabbits with experimental atherosclerosis increased the content of atherogenous classes of lipoproteins ( low density lipoproteins ( ldl ) and very low density lipoproteins ( vldl ) in the animals with distinct atheromatosis . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
136,
148
]
} | {
"id": "C0023825",
"name": "very low density lipoproteins",
"pos": [
188,
217
]
} |
studies of electrophoretic , kinetic properties and thermolability of the tumor enzyme demonstrated that only two hexokinase isoenzymes were found in sarcoma m-i hyaloplasm as compared with muscular tissue where isoenzymes i , ii and iv were observed . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
80,
86
]
} | {
"id": "C0022173",
"name": "isoenzymes",
"pos": [
212,
222
]
} |
the simultaneous administration of retinyl acetate and hydrocortisone decreased the accumulation of retinol and retinyl palmitate in liver tissue , increased the content of vitamin a in blood and did not influence its content in kidney . | NA | {
"id": "C0073109",
"name": "retinyl acetate",
"pos": [
35,
50
]
} | {
"id": "C0042839",
"name": "vitamin a",
"pos": [
173,
182
]
} |
the simultaneous administration of retinyl acetate and hydrocortisone decreased the accumulation of retinol and retinyl palmitate in liver tissue , increased the content of vitamin a in blood and did not influence its content in kidney . | NA | {
"id": "C0073115",
"name": "retinyl palmitate",
"pos": [
112,
129
]
} | {
"id": "C0042839",
"name": "vitamin a",
"pos": [
173,
182
]
} |
[ ultramorphometry of cells in a hamster embryo fibroblast culture following transformation by rous sarcoma virus ] . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
22,
27
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
48,
58
]
} |
[ characteristics of messenger rna for interferon and of interferon-inducing rna isolated from newcastle disease virus infected cells ] . | NA | {
"id": "C0035696",
"name": "messenger rna",
"pos": [
21,
34
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
77,
80
]
} |
in the first place there are an increase of frequency , intensity and duration of the attacks of angina pectoris , insufficient responsiveness to nitrangin , provocation of the attacks by slight causes and changes of the ecg as they are typical for the inner layer and outer layer ischaemia and the so-called rudimentary... | NA | {
"id": "C0022116",
"name": "ischaemia",
"pos": [
281,
290
]
} | {
"id": "C0021308",
"name": "infarction",
"pos": [
321,
331
]
} |
the fluorescence of adrenaline or noradrenaline was enhanced , in comparison with other methods , by the combined application of boric acid , copper-ions , mercaptoethanol and final reacidification . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
20,
30
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
34,
47
]
} |
for the differentiation of amines , adrenaline was oxidized at ph 2.85 and noradrenaline at ph 7 . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
36,
46
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
75,
88
]
} |
the normal values , determined in a collective of 17 healthy persons , were adrenaline ( x +/- s ) 44.8 +/- 16.9 nmol/24 h and noradrenaline ( x +/- s ) 224.0 +/- 68.0 nmol/24h . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
76,
86
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
127,
140
]
} |
the following enzymes were determined in the serum and plasma of man , dog and rat : alanine aminotransferase , asparate aminotransferase , alkaline phosphatase , lactate dehydrogenase and alpha-hydroxybutyrate dehydrogenase . | NA | {
"id": "C0001899",
"name": "alanine aminotransferase",
"pos": [
85,
109
]
} | {
"id": "C0002594",
"name": "aminotransferase",
"pos": [
121,
137
]
} |
from incubations with ldh and ladh the mercury containing coenzyme could be regarded by column be qualified for the x-ray structure analysis of the coenzyme-enzyme complex for some dehyrogenases based on the proportion of the heavy metal . | NA | {
"id": "C0025424",
"name": "mercury",
"pos": [
39,
46
]
} | {
"id": "C0347988",
"name": "heavy metal",
"pos": [
226,
237
]
} |
a binding value of deltad=1.15 g sodium dodecyl sulphate per g polypeptide was obtained which corresponds to a molar binding ratio of 100 mol dodecyl sulphate bound per mol of polypeptide . | NA | {
"id": "C0037506",
"name": "sodium dodecyl sulphate",
"pos": [
33,
56
]
} | {
"id": "C0058632",
"name": "dodecyl sulphate",
"pos": [
142,
158
]
} |
the effect of antibodies to neoxanthin on electron transport on the oxygen evolving side of photosystem ii and the reactions of this antiserum with variuos chloroplast preparations . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
14,
24
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
133,
142
]
} |
the distribution of the amino phospholipids is computed from the distribution of fluram in the membrane proteins in comjunction with the relative distribution of fluram between protein and lipid in native and sonicated vesicles . | NA | {
"id": "C0025252",
"name": "membrane proteins",
"pos": [
95,
112
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
177,
184
]
} |
with 14c labelled sugars a selectivity of the hexose uptake could be shown , galactose uptake amounting only to about one fifth that of glucose and mannose . | NA | {
"id": "C0019494",
"name": "hexose",
"pos": [
46,
52
]
} | {
"id": "C0016945",
"name": "galactose",
"pos": [
77,
86
]
} |
with 14c labelled sugars a selectivity of the hexose uptake could be shown , galactose uptake amounting only to about one fifth that of glucose and mannose . | NA | {
"id": "C0019494",
"name": "hexose",
"pos": [
46,
52
]
} | {
"id": "C0024742",
"name": "mannose",
"pos": [
148,
155
]
} |
the pregnancy zone protein antibody was isolated from an absorbed rabbit antiserum and coupled with cnbr-activated sepharose . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
27,
35
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
73,
82
]
} |
by means of a combination of immunoprecipitation and enzyme reaction in agar gel could be excluded that the pregnancy zone protein possesses activities of the following 11 enzymes : ceruloplasmin , leucine amino peptidase , alkaline phosphatase , carboxylic esterase , lactate dehydrogenase , malate dehydrogenase , glyc... | NA | {
"id": "C0008429",
"name": "cholinesterase",
"pos": [
384,
398
]
} | {
"id": "C0001044",
"name": "acetyl cholinesterase",
"pos": [
401,
422
]
} |
brain lesions associated with seizures in an epilepsy-prone colony of beagle dogs were studied in 68 dogs which died as a result of the disorder . | NA | {
"id": "C0036572",
"name": "seizures",
"pos": [
30,
38
]
} | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
45,
53
]
} |
thiocyanate , chlorine-anion , bicarbonate and sulfite affected noncompetitively the enzymatic activity as compared with mg2+-atp , adp and calcium . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
23,
28
]
} | {
"id": "C0038750",
"name": "sulfite",
"pos": [
47,
54
]
} |
concentration of the apolipoproteins studied was unaltered in men on transition from senile age to longevity and in women concentration of apolipoprotein a-i decreased from 143 mg to 130 mg/100 ml and of apo-e from 11.1 mg to 9.2 mg/100 ml . | NA | {
"id": "C0003591",
"name": "apolipoproteins",
"pos": [
21,
36
]
} | {
"id": "C0003595",
"name": "apo-e",
"pos": [
204,
209
]
} |
native vitamin a metabolites ( ra , 13-cis-ra ) and the structure-like substances ( c15-c20-retinoids and others ) at 10 ( -6 ) = 10 ( -7 ) m concentrations increased 2-2.5-fold the formation of t killers in vitro after stimulation of the lymphocytes by suboptimal doses of allogenic x-ray irradiated cells , the lymphoc... | NA | {
"id": "C0042839",
"name": "vitamin a",
"pos": [
7,
16
]
} | {
"id": "C0040845",
"name": "ra",
"pos": [
406,
408
]
} |
native vitamin a metabolites ( ra , 13-cis-ra ) and the structure-like substances ( c15-c20-retinoids and others ) at 10 ( -6 ) = 10 ( -7 ) m concentrations increased 2-2.5-fold the formation of t killers in vitro after stimulation of the lymphocytes by suboptimal doses of allogenic x-ray irradiated cells , the lymphoc... | NA | {
"id": "C0042839",
"name": "vitamin a",
"pos": [
7,
16
]
} | {
"id": "C0035339",
"name": "retinoids",
"pos": [
92,
101
]
} |
the activating effect of these cations was also exhibited in presence of low content of exogenous tpp but it was not found under conditions of saturation of pyruvate dehydrogenase complex with the coenzyme . | NA | {
"id": "C0039848",
"name": "tpp",
"pos": [
98,
101
]
} | {
"id": "C0009235",
"name": "coenzyme",
"pos": [
197,
205
]
} |
the levels of catecholamines ( adrenaline , noradrenaline , dopamine ) in gastrointestinal tumors and normal tissue adjacent to malignant tumor were studied . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
31,
41
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
44,
57
]
} |
the drug is a mixture of steroids of the androstane series , 2 alpha-methylhydrotestosterone and its three esters . | NA | {
"id": "C0038317",
"name": "steroids",
"pos": [
25,
33
]
} | {
"id": "C0002854",
"name": "androstane",
"pos": [
41,
51
]
} |
this article presents a review of the modifications of the hemoglobin , including reactions with different agents for the intra- or intermolecular cross-linking of hemoglobin , reactions with pyridoxal phosphate with or without subsequent polymerization , and manipulations for the encapsulation of hemoglobin to obtain ... | NA | {
"id": "C0019016",
"name": "a",
"pos": [
5,
6
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
299,
309
]
} |
cardiac arrhythmias and ventricular fibrillation are grave developments when the core temperature is below 28 degrees c . | NA | {
"id": "C0003811",
"name": "cardiac arrhythmias",
"pos": [
0,
19
]
} | {
"id": "C0042510",
"name": "ventricular fibrillation",
"pos": [
24,
48
]
} |
[ iatrogenic inhalation of disinfectants [ formalin ( formaldehyde , methanol ) , phenol ] during incubator care and cpap respiratory assistance of a newborn infant with respiratory distress syndrome ] . | NA | {
"id": "C0949307",
"name": "formalin",
"pos": [
43,
51
]
} | {
"id": "C0016564",
"name": "formaldehyde",
"pos": [
54,
66
]
} |
however , a relation ( p less than 0.01 ) to the degree of abnormal wall motion classified according to the presence of normokinesis , hypokinesis , akinesis or dyskinesis could be demonstrated for +pes after single but not after double premature stimuli . | NA | {
"id": "C0086439",
"name": "hypokinesis",
"pos": [
135,
146
]
} | {
"id": "C0013384",
"name": "dyskinesis",
"pos": [
161,
171
]
} |
the hemodynamic effects of doxaminol , a new , orally applicable beta-agonist , chemically dissimilar to catecholamines , were studied in comparison to those of dobutamine by means of thermodilution . | NA | {
"id": "C0007412",
"name": "catecholamines",
"pos": [
105,
119
]
} | {
"id": "C0012963",
"name": "dobutamine",
"pos": [
161,
171
]
} |
it was used an antiserum against human secretory component and an s-iga standard in the single radial immunodiffusion according to mancini and coworkers . | NA | {
"id": "C0036538",
"name": "secretory component",
"pos": [
39,
58
]
} | {
"id": "C0020838",
"name": "s-iga",
"pos": [
66,
71
]
} |
histochemical studies have been made on acetylcholinesterase and butyrylcholinesterase of human isocortex in early ontogenesis . | NA | {
"id": "C0001044",
"name": "acetylcholinesterase",
"pos": [
40,
60
]
} | {
"id": "C0008429",
"name": "butyrylcholinesterase",
"pos": [
65,
86
]
} |
in behavioural experiments , studies have been made of the sensitivity of frog tadpoles to amino acids and creatine . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
91,
102
]
} | {
"id": "C0010286",
"name": "creatine",
"pos": [
107,
115
]
} |
for different amino acids , the intensity of the evoked reaction decreases in the following order : ornithine -- valine -- lysine -- isoleucine -- arginine -- glutamine and tryptophan -- cysteine -- asparagine -- alanine -- beta-phenylalanine -- glycine . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
14,
25
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
235,
242
]
} |
for different amino acids , the intensity of the evoked reaction decreases in the following order : ornithine -- valine -- lysine -- isoleucine -- arginine -- glutamine and tryptophan -- cysteine -- asparagine -- alanine -- beta-phenylalanine -- glycine . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
14,
25
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
246,
253
]
} |
the method for the detection of trophoblastic beta-globulin may be used for evaluating the quality of immunoglobulin preparations as it indicates the degree of their purification from placental proteins . | NA | {
"id": "C0033002",
"name": "trophoblastic beta-globulin",
"pos": [
32,
59
]
} | {
"id": "C0032974",
"name": "placental proteins",
"pos": [
184,
202
]
} |
the comparative study of the chemical composition , immunobiological activity and some physico-chemical properties of lipopolysaccharide ( endotoxin ) of brucella cultures isolated from myomorph rodents in the north caucasus has been carried out . | NA | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
118,
136
]
} | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
139,
148
]
} |
the action of immune serum in vivo and in vitro leads rather quickly to quantitative changes in the surface antigenic structures of microbial cells , disappearing in the absence of contact with antibodies . | NA | {
"id": "C0020960",
"name": "immune serum",
"pos": [
14,
26
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
194,
204
]
} |
immunochemically pure tetanus antitoxin obtained from enzyme-treated horse serum is less reactogenic and anaphylactogenic and possesses higher therapeutic properties than antitoxin purified by nonspecific physico-chemical methods and containing ballast antigens . | NA | {
"id": "C0039615",
"name": "tetanus antitoxin",
"pos": [
22,
39
]
} | {
"id": "C0003445",
"name": "antitoxin",
"pos": [
171,
180
]
} |
the sequential changes in hydroxyproline concentration , 3h-proline incorporation and the histologic appearance of collagen , elastic fibres and fibronectin were noted . | NA | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
26,
40
]
} | {
"id": "C0033382",
"name": "proline",
"pos": [
60,
67
]
} |
blood pressure and heart rate remained unchanged during the infusions and significant changes in plasma noradrenaline ( average fall : 4.42 nmol x 1 ( -1 ) , range : -31.9- + 5.1 ) and in plasma adrenaline ( average fall : 1.06 nmol x 1 ( -1 ) , range : -16.3- + 5.11 ) were observed ( p less than 0.01 ) . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
104,
117
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
195,
205
]
} |
the circulatory effects of captopril , an angiotensin i-converting enzyme inhibitor , and saralasin , a competitive angiotensin ii antagonist , were studied during halothane anaesthesia in spontaneously hypertensive ( sh ) rats . | NA | {
"id": "C0036193",
"name": "saralasin",
"pos": [
90,
99
]
} | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
116,
130
]
} |
disoprofol , 2 mg/kg was given i.v . to induce anaesthesia after a bolus injection of either fentanyl 1.875 micrograms/kg or alfentanil 18.75 micrograms/kg . | NA | {
"id": "C0015846",
"name": "fentanyl",
"pos": [
93,
101
]
} | {
"id": "C0002026",
"name": "alfentanil",
"pos": [
125,
135
]
} |
anaesthesia was maintained with a continuous infusion of disoprofol 150 micrograms/kg/min and either fentanyl 0.125 micrograms/kg/min or alfentanil 1.25 micrograms/kg/min . | NA | {
"id": "C0015846",
"name": "fentanyl",
"pos": [
101,
109
]
} | {
"id": "C0002026",
"name": "alfentanil",
"pos": [
137,
147
]
} |
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